ERFE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1porphyrin-containing compound metabolic process (GO:0006778)9.93729958
2heme biosynthetic process (GO:0006783)9.70400040
3oxygen transport (GO:0015671)9.54331460
4erythrocyte maturation (GO:0043249)9.17772979
5erythrocyte development (GO:0048821)8.80027829
6gas transport (GO:0015669)8.75494781
7heme metabolic process (GO:0042168)7.98851206
8iron ion import (GO:0097286)6.28619008
9response to methylmercury (GO:0051597)6.19349151
10tetrapyrrole metabolic process (GO:0033013)6.15097654
11regulation of response to osmotic stress (GO:0047484)6.12135457
12myeloid cell development (GO:0061515)5.69457507
13glycine transport (GO:0015816)5.04664847
14negative regulation of erythrocyte differentiation (GO:0045647)4.96033795
15response to arsenic-containing substance (GO:0046685)4.87378027
16granulocyte differentiation (GO:0030851)4.81867089
17response to lead ion (GO:0010288)4.64325464
18response to insecticide (GO:0017085)4.61571763
19mitotic chromosome condensation (GO:0007076)4.47851515
20pigment biosynthetic process (GO:0046148)4.43990365
21erythrocyte differentiation (GO:0030218)4.28411110
22DNA topological change (GO:0006265)4.27214205
23mitotic sister chromatid segregation (GO:0000070)4.02247906
24embryonic hemopoiesis (GO:0035162)3.97041319
25cellular response to arsenic-containing substance (GO:0071243)3.94968664
26meiotic chromosome segregation (GO:0045132)3.92991826
27megakaryocyte development (GO:0035855)3.86837913
28pigment metabolic process (GO:0042440)3.74250578
29positive regulation of megakaryocyte differentiation (GO:0045654)3.68439111
30regulation of erythrocyte differentiation (GO:0045646)3.60369549
31sister chromatid segregation (GO:0000819)3.56054484
32regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.48756296
33regulation of RNA export from nucleus (GO:0046831)3.46418393
34cellular response to virus (GO:0098586)3.37164026
35protein-cofactor linkage (GO:0018065)3.31770785
36actin filament capping (GO:0051693)3.30856324
37protein targeting to plasma membrane (GO:0072661)3.26737357
38DNA replication initiation (GO:0006270)3.23024761
39positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.19565494
40decidualization (GO:0046697)3.17305884
41positive regulation of erythrocyte differentiation (GO:0045648)3.08772972
42DNA unwinding involved in DNA replication (GO:0006268)3.08306020
43proline biosynthetic process (GO:0006561)3.06334377
44platelet formation (GO:0030220)3.05828640
45cellular response to thyroid hormone stimulus (GO:0097067)3.02113148
46regulation of nucleobase-containing compound transport (GO:0032239)3.02110246
47hemopoiesis (GO:0030097)3.01126983
48DNA replication checkpoint (GO:0000076)2.97757521
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96494980
50DNA synthesis involved in DNA repair (GO:0000731)2.90752146
51positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.90331186
52definitive hemopoiesis (GO:0060216)2.85828557
53cofactor biosynthetic process (GO:0051188)2.83469502
54one-carbon compound transport (GO:0019755)2.82397459
55regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.77196863
56negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.77166491
57DNA strand renaturation (GO:0000733)2.75852684
58bicarbonate transport (GO:0015701)2.72870990
59telomere maintenance via semi-conservative replication (GO:0032201)2.71092246
60DNA strand elongation (GO:0022616)2.71067232
61negative regulation of viral entry into host cell (GO:0046597)2.70203104
62DNA strand elongation involved in DNA replication (GO:0006271)2.69096727
63chromosome condensation (GO:0030261)2.68863924
64negative regulation of actin filament depolymerization (GO:0030835)2.64536003
65protein localization to chromosome, centromeric region (GO:0071459)2.59980288
663-UTR-mediated mRNA stabilization (GO:0070935)2.58256346
67positive regulation of lymphocyte apoptotic process (GO:0070230)2.58235275
68cytoskeletal anchoring at plasma membrane (GO:0007016)2.50843074
69apoptotic DNA fragmentation (GO:0006309)2.45997882
70positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.45759973
71positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.45759973
72positive regulation of mitotic sister chromatid separation (GO:1901970)2.45759973
73DNA ligation (GO:0006266)2.44680917
74hematopoietic stem cell differentiation (GO:0060218)2.44654068
75N-terminal protein amino acid acetylation (GO:0006474)2.44317964
76deoxyribonucleotide biosynthetic process (GO:0009263)2.44213782
77chromosome segregation (GO:0007059)2.42581680
78hydrogen peroxide catabolic process (GO:0042744)2.41308513
79positive regulation of protein homooligomerization (GO:0032464)2.39152862
80negative regulation of fatty acid biosynthetic process (GO:0045717)2.38689586
81very-low-density lipoprotein particle assembly (GO:0034379)2.36416129
82positive regulation of granulocyte differentiation (GO:0030854)2.35734398
83DNA damage response, signal transduction resulting in transcription (GO:0042772)2.35724865
84DNA packaging (GO:0006323)2.35388566
85iron ion homeostasis (GO:0055072)2.35232003
86GDP-mannose metabolic process (GO:0019673)2.34102570
87DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.34083693
88positive regulation of chromosome segregation (GO:0051984)2.33909019
89regulation of chromatin binding (GO:0035561)2.33858376
90potassium ion export (GO:0071435)2.31910691
91modulation by virus of host process (GO:0019054)2.31232435
92positive regulation of gluconeogenesis (GO:0045722)2.31225183
93deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.29364922
94folic acid metabolic process (GO:0046655)2.27702070
95regulation of stem cell maintenance (GO:2000036)2.27204757
96protoporphyrinogen IX metabolic process (GO:0046501)16.4817364
97protoporphyrinogen IX biosynthetic process (GO:0006782)14.1688362
98porphyrin-containing compound biosynthetic process (GO:0006779)12.0990027
99tetrapyrrole biosynthetic process (GO:0033014)10.8429743
100hemoglobin metabolic process (GO:0020027)10.0588604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.94344538
2GATA1_22025678_ChIP-Seq_K562_Human6.35215797
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.04988277
4GATA1_19941826_ChIP-Seq_K562_Human4.59382864
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.30863374
6GATA2_19941826_ChIP-Seq_K562_Human2.62641372
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56473768
8TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.37480564
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.31785435
10SCL_19346495_ChIP-Seq_HPC-7_Human2.14644285
11GATA1_19941827_ChIP-Seq_MEL_Mouse2.13343116
12THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05357754
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04564155
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03982613
15VDR_21846776_ChIP-Seq_THP-1_Human1.97018173
16MYC_22102868_ChIP-Seq_BL_Human1.94231712
17KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.86613030
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86461841
19NCOR1_26117541_ChIP-Seq_K562_Human1.76297468
20GATA1_22383799_ChIP-Seq_G1ME_Mouse1.74812882
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73578447
22CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72408370
23ZNF263_19887448_ChIP-Seq_K562_Human1.69654036
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68189808
25ELF1_20517297_ChIP-Seq_JURKAT_Human1.65432421
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65068517
27DCP1A_22483619_ChIP-Seq_HELA_Human1.64429192
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.60116745
29XRN2_22483619_ChIP-Seq_HELA_Human1.59251833
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58855901
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.57872381
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.55850089
33CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55334837
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53768397
35TFEB_21752829_ChIP-Seq_HELA_Human1.47772949
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.42808665
37CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38990025
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37242943
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33145481
40LXR_22292898_ChIP-Seq_THP-1_Human1.31097552
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.29254541
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26310214
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26183037
44KDM5A_27292631_Chip-Seq_BREAST_Human1.25961676
45BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24413665
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.24395668
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24002683
48KDM2B_26808549_Chip-Seq_DND41_Human1.23528621
49CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23512464
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22574744
51TCF7_22412390_ChIP-Seq_EML_Mouse1.21151699
52P68_20966046_ChIP-Seq_HELA_Human1.20411647
53KDM2B_26808549_Chip-Seq_K562_Human1.19879272
54MAF_26560356_Chip-Seq_TH1_Human1.16892780
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15091809
56E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13461378
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13256239
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.08716807
59CIITA_25753668_ChIP-Seq_RAJI_Human1.08054897
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07299506
61BCL6_27268052_Chip-Seq_Bcells_Human1.06622344
62ATF3_27146783_Chip-Seq_COLON_Human1.04548630
63MAF_26560356_Chip-Seq_TH2_Human1.04335680
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.04025903
65GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02970167
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.02840998
67CTCF_21964334_Chip-Seq_Bcells_Human1.02466071
68GABP_19822575_ChIP-Seq_HepG2_Human1.02270291
69BCOR_27268052_Chip-Seq_Bcells_Human1.02235783
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00657381
71RACK7_27058665_Chip-Seq_MCF-7_Human0.99074018
72AR_21909140_ChIP-Seq_LNCAP_Human0.97163618
73TP53_22127205_ChIP-Seq_IMR90_Human0.96125697
74KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96080882
75YY1_22570637_ChIP-Seq_MALME-3M_Human0.96008557
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95583941
77MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95301023
78ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94758709
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94572032
80PHF8_20622854_ChIP-Seq_HELA_Human0.93970776
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93446196
82GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93104544
83YY1_21170310_ChIP-Seq_MESCs_Mouse0.92945986
84FOXP3_21729870_ChIP-Seq_TREG_Human0.92596911
85TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92414146
86TTF2_22483619_ChIP-Seq_HELA_Human0.92338109
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89513651
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88897707
89BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88661647
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88319771
91VDR_24763502_ChIP-Seq_THP-1_Human0.88302396
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88098795
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87829552
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87805130
95CTCF_21964334_ChIP-Seq_BJAB-B_Human0.87475706
96UTX_26944678_Chip-Seq_JUKART_Human0.86761029
97CREB1_26743006_Chip-Seq_LNCaP_Human0.86231265
98KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86052101
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85773554
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85568579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract6.07558001
2MP0005397_hematopoietic_system_phenotyp3.17591527
3MP0001545_abnormal_hematopoietic_system3.17591527
4MP0003111_abnormal_nucleus_morphology3.01209103
5MP0009278_abnormal_bone_marrow2.24192087
6MP0008995_early_reproductive_senescence2.14213690
7MP0010094_abnormal_chromosome_stability2.02513809
8MP0004147_increased_porphyrin_level11.0981030
9MP0003656_abnormal_erythrocyte_physiolo10.0910879
10MP0003303_peritoneal_inflammation1.88790903
11MP0010307_abnormal_tumor_latency1.80816680
12MP0005636_abnormal_mineral_homeostasis1.60436874
13MP0002877_abnormal_melanocyte_morpholog1.57921743
14MP0003186_abnormal_redox_activity1.54884950
15MP0003786_premature_aging1.51981644
16MP0003693_abnormal_embryo_hatching1.46122327
17MP0003077_abnormal_cell_cycle1.45671687
18MP0008438_abnormal_cutaneous_collagen1.43525587
19MP0008058_abnormal_DNA_repair1.36204596
20MP0005076_abnormal_cell_differentiation1.24839194
21MP0009333_abnormal_splenocyte_physiolog1.24368412
22MP0005451_abnormal_body_composition1.23830296
23MP0004957_abnormal_blastocyst_morpholog1.17296743
24MP0004808_abnormal_hematopoietic_stem1.16963519
25MP0005171_absent_coat_pigmentation1.11025095
26MP0002163_abnormal_gland_morphology1.10460538
27MP0002095_abnormal_skin_pigmentation1.07169723
28MP0001542_abnormal_bone_strength1.01358838
29MP0000313_abnormal_cell_death1.00489558
30MP0009931_abnormal_skin_appearance0.99278069
31MP0009764_decreased_sensitivity_to0.94114457
32MP0000015_abnormal_ear_pigmentation0.93857755
33MP0003172_abnormal_lysosome_physiology0.91803408
34MP0004185_abnormal_adipocyte_glucose0.88847338
35MP0002653_abnormal_ependyma_morphology0.85682995
36MP0002722_abnormal_immune_system0.85416366
37MP0002398_abnormal_bone_marrow0.84952780
38MP0008007_abnormal_cellular_replicative0.83795381
39MP0001529_abnormal_vocalization0.82219120
40MP0001188_hyperpigmentation0.81109528
41MP0005501_abnormal_skin_physiology0.79587107
42MP0000350_abnormal_cell_proliferation0.78326585
43MP0003453_abnormal_keratinocyte_physiol0.77934539
44MP0009697_abnormal_copulation0.77863235
45MP0000749_muscle_degeneration0.74711714
46MP0002332_abnormal_exercise_endurance0.74371827
47MP0002080_prenatal_lethality0.74305352
48MP0003191_abnormal_cellular_cholesterol0.70491043
49MP0003705_abnormal_hypodermis_morpholog0.69576770
50MP0000689_abnormal_spleen_morphology0.69369413
51MP0002019_abnormal_tumor_incidence0.68761837
52MP0009765_abnormal_xenobiotic_induced0.68304503
53MP0001730_embryonic_growth_arrest0.68199222
54MP0001697_abnormal_embryo_size0.67862736
55MP0008775_abnormal_heart_ventricle0.66261584
56MP0003806_abnormal_nucleotide_metabolis0.65569785
57MP0008057_abnormal_DNA_replication0.64992613
58MP0006036_abnormal_mitochondrial_physio0.64706878
59MP0000609_abnormal_liver_physiology0.63441246
60MP0000343_altered_response_to0.61187080
61MP0002429_abnormal_blood_cell0.60826938
62MP0001672_abnormal_embryogenesis/_devel0.59354573
63MP0005380_embryogenesis_phenotype0.59354573
64MP0002210_abnormal_sex_determination0.59030346
65MP0003984_embryonic_growth_retardation0.58985589
66MP0004145_abnormal_muscle_electrophysio0.58041277
67MP0003279_aneurysm0.55875669
68MP0002088_abnormal_embryonic_growth/wei0.55288246
69MP0002086_abnormal_extraembryonic_tissu0.54920652
70MP0001191_abnormal_skin_condition0.53940968
71MP0008932_abnormal_embryonic_tissue0.53523726
72MP0004233_abnormal_muscle_weight0.53444353
73MP0005503_abnormal_tendon_morphology0.53277091
74MP0003950_abnormal_plasma_membrane0.51800339
75MP0005621_abnormal_cell_physiology0.51345560
76MP0000358_abnormal_cell_content/0.50833733
77MP0005058_abnormal_lysosome_morphology0.50644712
78MP0001664_abnormal_digestion0.50491176
79MP0000747_muscle_weakness0.50443558
80MP0001764_abnormal_homeostasis0.49193400
81MP0000598_abnormal_liver_morphology0.46898757
82MP0005384_cellular_phenotype0.45834721
83MP0000703_abnormal_thymus_morphology0.44781015
84MP0001929_abnormal_gametogenesis0.44367627
85MP0005174_abnormal_tail_pigmentation0.44207363
86MP0005266_abnormal_metabolism0.42529140
87MP0005379_endocrine/exocrine_gland_phen0.42047913
88MP0002060_abnormal_skin_morphology0.41925786
89MP0003045_fibrosis0.41600648
90MP0000490_abnormal_crypts_of0.41597651
91MP0009840_abnormal_foam_cell0.40344584
92MP0001661_extended_life_span0.40278311
93MP0003698_abnormal_male_reproductive0.40146105
94MP0003699_abnormal_female_reproductive0.39979316
95MP0001784_abnormal_fluid_regulation0.39787636
96MP0008260_abnormal_autophagy0.38521182
97MP0000678_abnormal_parathyroid_gland0.38141343
98MP0010771_integument_phenotype0.37792471
99MP0000372_irregular_coat_pigmentation0.37706701
100MP0002132_abnormal_respiratory_system0.37071796

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytosis (HP:0001923)8.80627888
2Cholelithiasis (HP:0001081)7.17315893
3Hypochromic microcytic anemia (HP:0004840)6.56368612
4Abnormality of reticulocytes (HP:0004312)6.52971457
5Abnormal gallbladder morphology (HP:0012437)6.45655532
6Paralysis (HP:0003470)6.10383052
7Cholecystitis (HP:0001082)5.84709962
8Abnormal gallbladder physiology (HP:0012438)5.84709962
9Abnormal hemoglobin (HP:0011902)5.50859414
10Acanthocytosis (HP:0001927)5.31855851
11Abnormality of the gallbladder (HP:0005264)5.19363842
12Microcytic anemia (HP:0001935)4.97605107
13Polycythemia (HP:0001901)4.93270052
14Hyperbilirubinemia (HP:0002904)4.92976513
15Diaphragmatic weakness (HP:0009113)4.78129794
16Hypochromic anemia (HP:0001931)4.62063065
17Ileus (HP:0002595)4.19329479
18Insomnia (HP:0100785)3.71902242
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.53064832
20Nonimmune hydrops fetalis (HP:0001790)3.36030353
21Abnormal number of erythroid precursors (HP:0012131)3.27943918
22Chromsome breakage (HP:0040012)3.19946947
23Abnormality of iron homeostasis (HP:0011031)3.13615297
24Abnormality of transition element cation homeostasis (HP:0011030)2.92788453
25Abnormality of cells of the erythroid lineage (HP:0012130)2.86588774
26Increased serum ferritin (HP:0003281)2.78899948
27Hypertensive crisis (HP:0100735)2.75745556
28Osteomalacia (HP:0002749)2.69937646
29Pallor (HP:0000980)2.57684744
30Nausea (HP:0002018)2.52501428
31Autoimmune thrombocytopenia (HP:0001973)2.41960692
32Duplicated collecting system (HP:0000081)2.41019139
33Cutaneous photosensitivity (HP:0000992)2.38343759
34Hyponatremia (HP:0002902)2.37307270
35Hepatocellular carcinoma (HP:0001402)2.29847579
36Cerebral palsy (HP:0100021)2.28854057
37Toxemia of pregnancy (HP:0100603)2.22164664
38Rectal prolapse (HP:0002035)2.20724943
39Abnormality of sodium homeostasis (HP:0010931)2.12539585
40Abnormality of the fingertips (HP:0001211)2.08506321
41Abnormality of the renal collecting system (HP:0004742)2.00343349
42Abnormality of the heme biosynthetic pathway (HP:0010472)13.9705054
43Poikilocytosis (HP:0004447)10.7205853
44Short middle phalanx of the 5th finger (HP:0004220)1.92043125
45Neoplasm of head and neck (HP:0012288)1.90282382
46Esophageal neoplasm (HP:0100751)1.90282382
47Gastrointestinal infarctions (HP:0005244)1.88819198
48Breast hypoplasia (HP:0003187)1.88399768
49Birth length less than 3rd percentile (HP:0003561)1.87409503
50Abnormality of DNA repair (HP:0003254)1.85053056
51Ectopic kidney (HP:0000086)1.81224296
52Hypoparathyroidism (HP:0000829)1.80260374
53Ureteral duplication (HP:0000073)1.73652923
54Reticulocytopenia (HP:0001896)1.72363434
55Premature rupture of membranes (HP:0001788)1.71370781
56Albinism (HP:0001022)1.70453641
57Aplasia/Hypoplasia of the earlobes (HP:0009906)1.66352032
58Hyperthyroidism (HP:0000836)1.61716997
59Aplasia/Hypoplasia of the uvula (HP:0010293)1.60922118
60Aplasia/Hypoplasia of the sacrum (HP:0008517)1.58730429
61Gastrointestinal dysmotility (HP:0002579)1.57448687
62Genu recurvatum (HP:0002816)1.54015385
63Long clavicles (HP:0000890)1.52414945
64Hyperparathyroidism (HP:0000843)1.52310672
65Absent thumb (HP:0009777)1.52121247
66Orthostatic hypotension (HP:0001278)1.51314478
67Anhidrosis (HP:0000970)1.51099023
68Severe visual impairment (HP:0001141)1.50405732
69Long palpebral fissure (HP:0000637)1.48161404
70Hypergonadotropic hypogonadism (HP:0000815)1.47388464
71Generalized hyperpigmentation (HP:0007440)1.47011632
72Myelodysplasia (HP:0002863)1.45635130
73Redundant skin (HP:0001582)1.40314620
74Abnormality of chromosome segregation (HP:0002916)1.37039367
75Abnormality of the aortic arch (HP:0012303)1.36559033
76Squamous cell carcinoma (HP:0002860)1.35707825
77Bone marrow hypocellularity (HP:0005528)1.35471757
78Nasal polyposis (HP:0100582)1.35371567
79Meckel diverticulum (HP:0002245)1.33536550
80Delusions (HP:0000746)1.31742757
81Abnormality of the preputium (HP:0100587)1.31582837
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.30436371
83Small intestinal stenosis (HP:0012848)1.30198633
84Duodenal stenosis (HP:0100867)1.30198633
85Autoimmune hemolytic anemia (HP:0001890)1.29971880
86Abnormality of chromosome stability (HP:0003220)1.29237513
87Abnormality of nail color (HP:0100643)1.28976390
88Increased IgM level (HP:0003496)1.27927181
89Broad distal phalanx of finger (HP:0009836)1.27399355
90Cutaneous melanoma (HP:0012056)1.27122863
91Abnormality of the nasal mucosa (HP:0000433)1.26914608
92Abnormality of the ileum (HP:0001549)1.26424643
93Ulnar bowing (HP:0003031)1.26059100
94Dysautonomia (HP:0002459)1.25622954
95Hypoplasia of the capital femoral epiphysis (HP:0003090)1.24969569
96Abnormality of dental color (HP:0011073)1.24488384
97Facial hemangioma (HP:0000329)1.24425845
98Abnormality of the phalanges of the hallux (HP:0010057)1.24156131
99Myopathic facies (HP:0002058)1.22389586
100Abnormality of the thoracic spine (HP:0100711)1.21941621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK17.54960967
2PRPF4B4.46428965
3TAOK23.29973690
4IRAK32.97690100
5MAP3K112.39067303
6TAOK12.15587948
7DYRK32.13321541
8MAP2K32.11470421
9CDC72.11400885
10CLK12.00714795
11SMG11.88217821
12NME21.80436668
13PIM11.73369694
14TRIB31.71998961
15STK41.68119136
16BMX1.59390696
17MAP3K31.59116798
18CAMK1D1.53857825
19CHEK21.52548909
20BRAF1.52385566
21TXK1.45732446
22BUB11.42890376
23RPS6KA51.41908616
24BRSK11.41105329
25EEF2K1.40727035
26TAOK31.29180002
27PLK11.25106472
28CDK121.19639916
29ICK1.19435401
30MAP3K101.17371060
31MAP3K81.16501167
32PLK31.13533389
33IKBKB1.12399220
34PLK41.12221217
35ZAK1.10036292
36TAF11.04859737
37MARK31.04146592
38TTK1.04037761
39HIPK21.03745868
40RPS6KL11.03631540
41RPS6KC11.03631540
42CDK41.01375852
43MAP2K20.99549413
44RPS6KA60.95864140
45CDK80.92360777
46WEE10.87872995
47WNK10.82841024
48PBK0.82663020
49MAP2K10.82599999
50CHEK10.81758925
51CAMK1G0.81723199
52VRK20.81607360
53TLK10.80167620
54MAPK110.79024829
55ATR0.76468381
56AURKA0.76050312
57IRAK20.74850824
58CDK70.74800494
59NEK20.72006149
60ABL20.71595154
61STK160.67734433
62AKT20.66949290
63PIM20.66835827
64MAP3K50.64436194
65MTOR0.63547856
66TRPM70.63184249
67RPS6KA20.59322887
68PRKAA20.58962804
69ATM0.57390842
70GRK60.57369014
71SGK30.56451638
72SIK10.54404863
73CDK90.52878562
74CCNB10.51837670
75MAP4K10.51488913
76CHUK0.51330369
77CDK11A0.51297827
78DYRK1B0.49975920
79TBK10.49594099
80SCYL20.49558501
81STK110.48024485
82BRSK20.46703090
83CDK150.46070335
84CDK20.44462380
85KSR10.44207864
86CDK10.42534323
87AKT10.41776015
88MAP3K10.41737523
89DAPK30.40733895
90PTK2B0.39270092
91CDK60.39142056
92CDK180.38523428
93PRKCI0.38354672
94MAPKAPK50.38204297
95VRK10.36670762
96RPS6KB20.36193895
97AURKB0.35945707
98CDK140.35071448
99GSK3A0.33785515
100PRKAA10.32334130

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008605.19368661
2Malaria_Homo sapiens_hsa051443.43578572
3DNA replication_Homo sapiens_hsa030303.38222671
4Cell cycle_Homo sapiens_hsa041102.74523905
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.73609736
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.61380628
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.50091379
8Sulfur relay system_Homo sapiens_hsa041222.34353036
9Bladder cancer_Homo sapiens_hsa052192.25782573
10Homologous recombination_Homo sapiens_hsa034402.20944562
11Mismatch repair_Homo sapiens_hsa034302.06418333
12Fanconi anemia pathway_Homo sapiens_hsa034602.04528254
13African trypanosomiasis_Homo sapiens_hsa051431.93934306
14Base excision repair_Homo sapiens_hsa034101.87262582
15Nucleotide excision repair_Homo sapiens_hsa034201.77117938
16One carbon pool by folate_Homo sapiens_hsa006701.73858865
17Collecting duct acid secretion_Homo sapiens_hsa049661.64606066
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62509504
19Chronic myeloid leukemia_Homo sapiens_hsa052201.53340033
20Non-small cell lung cancer_Homo sapiens_hsa052231.51058475
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48770028
22Pancreatic cancer_Homo sapiens_hsa052121.36001011
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33220574
24p53 signaling pathway_Homo sapiens_hsa041151.32805754
25Small cell lung cancer_Homo sapiens_hsa052221.16959459
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10949846
27Pyrimidine metabolism_Homo sapiens_hsa002401.10912354
28Non-homologous end-joining_Homo sapiens_hsa034501.07830518
29Hematopoietic cell lineage_Homo sapiens_hsa046401.07298567
30Acute myeloid leukemia_Homo sapiens_hsa052211.07023030
31Apoptosis_Homo sapiens_hsa042101.06541600
32mTOR signaling pathway_Homo sapiens_hsa041501.04537422
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.04074360
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.01446296
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01367199
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99046291
37Melanoma_Homo sapiens_hsa052180.97343437
38Basal transcription factors_Homo sapiens_hsa030220.96406637
39Spliceosome_Homo sapiens_hsa030400.95624826
40MicroRNAs in cancer_Homo sapiens_hsa052060.95297942
41Fructose and mannose metabolism_Homo sapiens_hsa000510.94710742
42Hepatitis B_Homo sapiens_hsa051610.94622541
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94064580
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92708445
45Regulation of autophagy_Homo sapiens_hsa041400.92178808
46TNF signaling pathway_Homo sapiens_hsa046680.89946775
47Prostate cancer_Homo sapiens_hsa052150.88467100
48Central carbon metabolism in cancer_Homo sapiens_hsa052300.87103426
49Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86700786
50Herpes simplex infection_Homo sapiens_hsa051680.83082272
51N-Glycan biosynthesis_Homo sapiens_hsa005100.82997983
52RNA transport_Homo sapiens_hsa030130.82685747
53Glioma_Homo sapiens_hsa052140.81105625
54AMPK signaling pathway_Homo sapiens_hsa041520.79257768
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78798656
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77585708
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77076943
58HTLV-I infection_Homo sapiens_hsa051660.76766644
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76565756
60Systemic lupus erythematosus_Homo sapiens_hsa053220.73412489
61Nitrogen metabolism_Homo sapiens_hsa009100.73310374
62Biosynthesis of amino acids_Homo sapiens_hsa012300.73031682
63FoxO signaling pathway_Homo sapiens_hsa040680.72249312
64Viral carcinogenesis_Homo sapiens_hsa052030.72245142
65ABC transporters_Homo sapiens_hsa020100.71767147
66HIF-1 signaling pathway_Homo sapiens_hsa040660.70183517
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69447945
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69430718
69Notch signaling pathway_Homo sapiens_hsa043300.69377198
70Renal cell carcinoma_Homo sapiens_hsa052110.65539890
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64573107
72Alcoholism_Homo sapiens_hsa050340.63982015
73Type II diabetes mellitus_Homo sapiens_hsa049300.62855094
74Selenocompound metabolism_Homo sapiens_hsa004500.60095369
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.59745750
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58742860
77Pyruvate metabolism_Homo sapiens_hsa006200.54145306
78Oocyte meiosis_Homo sapiens_hsa041140.54036359
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53053430
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51631939
81Epstein-Barr virus infection_Homo sapiens_hsa051690.51609253
82Synaptic vesicle cycle_Homo sapiens_hsa047210.50827239
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49162643
84Influenza A_Homo sapiens_hsa051640.49086630
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48673523
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.47971005
87Measles_Homo sapiens_hsa051620.47256861
88Purine metabolism_Homo sapiens_hsa002300.46945534
89Lysine degradation_Homo sapiens_hsa003100.44471074
90Thyroid cancer_Homo sapiens_hsa052160.44357495
91VEGF signaling pathway_Homo sapiens_hsa043700.42255093
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41791601
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.40805282
94Hepatitis C_Homo sapiens_hsa051600.40548122
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40318630
96Glutathione metabolism_Homo sapiens_hsa004800.39988098
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.38595015
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.37112723
99Sphingolipid metabolism_Homo sapiens_hsa006000.36833850
100mRNA surveillance pathway_Homo sapiens_hsa030150.36754171

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