ERGIC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cycling membrane protein which is an endoplasmic reticulum-golgi intermediate compartment (ERGIC) protein which interacts with other members of this protein family to increase their turnover. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.54448494
2Golgi transport vesicle coating (GO:0048200)6.54448494
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.38752271
4protein retention in ER lumen (GO:0006621)5.19792309
5activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.51861324
6positive regulation of nuclease activity (GO:0032075)4.36371434
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.93455829
8regulation of nuclease activity (GO:0032069)3.89455388
9endoplasmic reticulum unfolded protein response (GO:0030968)3.87941975
10apoptotic cell clearance (GO:0043277)3.86447383
11negative regulation of cell size (GO:0045792)3.83938068
12regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.82606370
13cellular response to unfolded protein (GO:0034620)3.70801734
14negative regulation of fatty acid transport (GO:2000192)3.66304545
15regulation of fatty acid beta-oxidation (GO:0031998)3.63183082
164-hydroxyproline metabolic process (GO:0019471)3.62862459
17exocrine pancreas development (GO:0031017)3.62240516
18regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.57057092
19ER-nucleus signaling pathway (GO:0006984)3.57043460
20protein localization to endosome (GO:0036010)3.50396327
21maternal placenta development (GO:0001893)3.49845721
22cell adhesion mediated by integrin (GO:0033627)3.44909608
23cellular response to topologically incorrect protein (GO:0035967)3.44698489
24COPII vesicle coating (GO:0048208)3.41102668
25vesicle coating (GO:0006901)3.40022013
26insulin-like growth factor receptor signaling pathway (GO:0048009)3.38576062
27collagen fibril organization (GO:0030199)3.32087483
28peptidyl-proline hydroxylation (GO:0019511)3.31115406
29iron ion import (GO:0097286)3.30277111
30protein heterotrimerization (GO:0070208)3.29988081
31positive regulation of Cdc42 GTPase activity (GO:0043089)3.25856966
32protein hydroxylation (GO:0018126)3.20199001
33hippo signaling (GO:0035329)3.18333701
34regulation of translational fidelity (GO:0006450)3.17396168
35axon extension involved in axon guidance (GO:0048846)3.16259620
36neuron projection extension involved in neuron projection guidance (GO:1902284)3.16259620
37positive regulation of fatty acid beta-oxidation (GO:0032000)3.12824127
38lysine catabolic process (GO:0006554)3.09985187
39lysine metabolic process (GO:0006553)3.09985187
40skin morphogenesis (GO:0043589)3.09562766
41response to endoplasmic reticulum stress (GO:0034976)3.06994181
42polarized epithelial cell differentiation (GO:0030859)3.04254079
43chondrocyte proliferation (GO:0035988)3.03900158
44adherens junction assembly (GO:0034333)3.02510464
45alpha-linolenic acid metabolic process (GO:0036109)3.00913526
46low-density lipoprotein particle clearance (GO:0034383)2.98084615
47mannose metabolic process (GO:0006013)2.97978595
48negative regulation of fibrinolysis (GO:0051918)2.97893331
49positive regulation of glycogen biosynthetic process (GO:0045725)2.97313910
50plasma membrane repair (GO:0001778)2.97150527
51glucocorticoid receptor signaling pathway (GO:0042921)2.94042843
52pentose-phosphate shunt (GO:0006098)2.93762753
53endodermal cell differentiation (GO:0035987)2.92009869
54response to laminar fluid shear stress (GO:0034616)2.91071145
55cerebellar Purkinje cell layer development (GO:0021680)2.90350683
56cytoskeletal anchoring at plasma membrane (GO:0007016)2.89381064
57regulation of cholesterol homeostasis (GO:2000188)2.88160365
58tricarboxylic acid metabolic process (GO:0072350)2.86498459
59regulation of extracellular matrix disassembly (GO:0010715)2.85064644
60response to unfolded protein (GO:0006986)2.84854344
61hypotonic response (GO:0006971)2.83103959
62stress fiber assembly (GO:0043149)2.82694281
63folic acid-containing compound biosynthetic process (GO:0009396)2.81742141
64positive regulation of extracellular matrix organization (GO:1903055)2.78497042
65positive regulation of endothelial cell apoptotic process (GO:2000353)2.78011034
66pinocytosis (GO:0006907)2.77684995
67basement membrane organization (GO:0071711)2.72084287
68sulfur amino acid catabolic process (GO:0000098)2.70769812
69embryonic process involved in female pregnancy (GO:0060136)2.70322397
70response to topologically incorrect protein (GO:0035966)2.69838097
71epithelial cell-cell adhesion (GO:0090136)2.68550791
72cell migration involved in sprouting angiogenesis (GO:0002042)2.66797024
73planar cell polarity pathway involved in neural tube closure (GO:0090179)2.64625638
74barbed-end actin filament capping (GO:0051016)2.63970452
75activation of Rac GTPase activity (GO:0032863)2.62821760
76proline biosynthetic process (GO:0006561)2.62770487
77peptidyl-lysine dimethylation (GO:0018027)2.60680398
78oxaloacetate metabolic process (GO:0006107)2.59953201
79NADPH regeneration (GO:0006740)2.59106398
80urea cycle (GO:0000050)2.59005016
81regulation of hippo signaling (GO:0035330)2.58993872
82regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.58302682
83vascular endothelial growth factor signaling pathway (GO:0038084)2.57818620
84peptidyl-glutamic acid carboxylation (GO:0017187)2.57634102
85protein carboxylation (GO:0018214)2.57634102
86heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.57335438
87branching involved in mammary gland duct morphogenesis (GO:0060444)2.54095690
88regulation of plasminogen activation (GO:0010755)2.54011160
89urea metabolic process (GO:0019627)2.53841618
90cell-substrate adherens junction assembly (GO:0007045)2.51372131
91focal adhesion assembly (GO:0048041)2.51372131
92positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.51080931
93cellular modified amino acid catabolic process (GO:0042219)2.50595154
94desmosome organization (GO:0002934)2.50071535
95positive regulation of nitric-oxide synthase activity (GO:0051000)2.49948516
96midgut development (GO:0007494)2.48955823
97embryonic foregut morphogenesis (GO:0048617)2.48710052
98negative regulation of lipid transport (GO:0032369)2.48408890
99vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.47475353
100amyloid precursor protein catabolic process (GO:0042987)2.46721387
101blood vessel endothelial cell migration (GO:0043534)2.46487093
102endothelial cell chemotaxis (GO:0035767)2.45936536
103regulation of early endosome to late endosome transport (GO:2000641)2.45511706
104positive regulation of glycogen metabolic process (GO:0070875)2.45336139
105positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.45146269
106cell-substrate junction assembly (GO:0007044)2.43857915
107semaphorin-plexin signaling pathway (GO:0071526)2.42091255
108positive regulation of fatty acid oxidation (GO:0046321)2.41953107
109positive regulation of histone deacetylation (GO:0031065)2.41231312
110regulation of fatty acid oxidation (GO:0046320)2.41199453
111regulation of glucose import in response to insulin stimulus (GO:2001273)2.40805685
112regulation of tight junction assembly (GO:2000810)2.40348181
113epithelial cell differentiation involved in prostate gland development (GO:0060742)2.40117235
114regulation of translational termination (GO:0006449)2.39750412
115G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.39539647
116positive regulation of blood vessel endothelial cell migration (GO:0043536)2.39170273
117negative regulation of erythrocyte differentiation (GO:0045647)2.38233039
118positive regulation of receptor recycling (GO:0001921)2.37960210
119detection of molecule of bacterial origin (GO:0032490)2.37879662
120regulation of endothelial cell chemotaxis (GO:2001026)2.37412950
121ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.37231953
1222-oxoglutarate metabolic process (GO:0006103)2.35657824
123cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.34934368
124valine metabolic process (GO:0006573)2.34722634
125epoxygenase P450 pathway (GO:0019373)2.34648893
126regulation of polysaccharide biosynthetic process (GO:0032885)2.34521696
127establishment of apical/basal cell polarity (GO:0035089)2.34086979
128membrane protein ectodomain proteolysis (GO:0006509)2.33536821
129regulation of cholesterol biosynthetic process (GO:0045540)2.32894571
130heparan sulfate proteoglycan metabolic process (GO:0030201)2.32584081
131cysteine metabolic process (GO:0006534)2.32482872
132heterochromatin organization (GO:0070828)2.32171144
133regulation of extracellular matrix organization (GO:1903053)2.32091222
134endocardial cushion development (GO:0003197)2.31856855
135regulation of fibrinolysis (GO:0051917)2.30614971
136negative regulation of viral release from host cell (GO:1902187)2.26844667
137positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.25133522
138positive regulation of keratinocyte differentiation (GO:0045618)2.24233783
139modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.23747176
140positive regulation by organism of defense response of other organism involved in symbiotic interact2.23747176
141modulation by symbiont of host immune response (GO:0052553)2.23747176
142positive regulation by symbiont of host defense response (GO:0052509)2.23747176
143modulation by symbiont of host defense response (GO:0052031)2.23747176
144modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.23747176
145antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.22039093
146apoptotic process involved in morphogenesis (GO:0060561)2.21507861
147regulation of protein activation cascade (GO:2000257)2.21423288
148regulation of complement activation (GO:0030449)2.21212502
149nitrogen cycle metabolic process (GO:0071941)2.19927084
150surfactant homeostasis (GO:0043129)2.18924747
151glucose catabolic process (GO:0006007)2.15978345
152glucose 6-phosphate metabolic process (GO:0051156)2.13979196
153antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.13865967
154cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.13102891
155import into cell (GO:0098657)2.12783575
156atrioventricular valve morphogenesis (GO:0003181)2.11958765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.69749848
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.59912296
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.59318745
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.57370561
5CLOCK_20551151_ChIP-Seq_293T_Human3.27145312
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.18777903
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.12525848
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.12170613
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.54979232
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.46251853
11MYC_22102868_ChIP-Seq_BL_Human2.28565082
12* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22491365
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.16901053
14RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.13170974
15LXR_22292898_ChIP-Seq_THP-1_Human2.07256186
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.06164462
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.05295935
18ZNF263_19887448_ChIP-Seq_K562_Human2.03526359
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.00127748
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.99115583
21* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.90893767
22* LXR_22158963_ChIP-Seq_LIVER_Mouse1.90811126
23ATF3_27146783_Chip-Seq_COLON_Human1.88389069
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.87075162
25* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83215534
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83144295
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.83039605
28P300_27058665_Chip-Seq_ZR-75-30cells_Human1.81032333
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.80055245
30RACK7_27058665_Chip-Seq_MCF-7_Human1.78843331
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76135109
32KDM2B_26808549_Chip-Seq_DND41_Human1.75957383
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74116055
34DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.67250275
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63724270
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63241029
37* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63093787
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57877294
39* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56892140
40VDR_24763502_ChIP-Seq_THP-1_Human1.54453719
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52035929
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48025489
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.47273535
44KDM2B_26808549_Chip-Seq_K562_Human1.46731646
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46237678
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.45457516
47* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44787157
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44288448
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44161922
50* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41427727
51TCF7_22412390_ChIP-Seq_EML_Mouse1.40357500
52* CREB1_26743006_Chip-Seq_LNCaP_Human1.38125351
53FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.37764334
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.37374204
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36332021
56ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35227096
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34734729
58TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32772259
59TP53_22127205_ChIP-Seq_IMR90_Human1.32487825
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32067505
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31848053
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.28983663
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27487279
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25798148
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24381019
66* KDM2B_26808549_Chip-Seq_JURKAT_Human1.23178028
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.22750124
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22138016
69MAF_26560356_Chip-Seq_TH1_Human1.21395720
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21370646
71CHD1_26751641_Chip-Seq_LNCaP_Human1.19933194
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19395530
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19385553
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19175138
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18476086
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17830045
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15229858
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15229858
79* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14882756
80VDR_21846776_ChIP-Seq_THP-1_Human1.14838767
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14610033
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14006227
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13811192
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.12647953
85AR_21909140_ChIP-Seq_LNCAP_Human1.12280689
86* SMC4_20622854_ChIP-Seq_HELA_Human1.11281364
87* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08968534
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08774548
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08751974
90TBX20_22328084_ChIP-Seq_HEART_Mouse1.08004030
91TBX20_22080862_ChIP-Seq_HEART_Mouse1.08004030
92* BRD4_25478319_ChIP-Seq_HGPS_Human1.07985842
93* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07009558
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06344933
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.06166809
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05867256
97NCOR1_26117541_ChIP-Seq_K562_Human1.05046671
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.04554059
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04484285
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04182546
101TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.02921730
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02544570
103TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02419466
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02107339
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02106585
106SA1_27219007_Chip-Seq_ERYTHROID_Human1.01983684
107* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00676575
108GATA6_25053715_ChIP-Seq_YYC3_Human1.00663690
109MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00534704
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.99625909
111* FOXA2_19822575_ChIP-Seq_HepG2_Human0.99576334
112* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99235375
113P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99180872
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99064051
115* UTX_26944678_Chip-Seq_JUKART_Human0.98629052
116* TET1_21451524_ChIP-Seq_MESCs_Mouse0.98172550
117* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97343367
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96629123
119RUNX1_27514584_Chip-Seq_MCF-7_Human0.96486399
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96267869
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.96117035
122* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95571846
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95430814
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94794730
125* TP53_23651856_ChIP-Seq_MEFs_Mouse0.94562208
126GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94516337
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94267293
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93097795
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92793711

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.09861245
2MP0008438_abnormal_cutaneous_collagen4.84250925
3MP0005451_abnormal_body_composition3.06826184
4MP0010352_gastrointestinal_tract_polyps2.76111127
5MP0005275_abnormal_skin_tensile2.66808443
6MP0003191_abnormal_cellular_cholesterol2.63843323
7MP0003283_abnormal_digestive_organ2.46674803
8MP0009780_abnormal_chondrocyte_physiolo2.31228745
9MP0005503_abnormal_tendon_morphology2.24249065
10MP0009840_abnormal_foam_cell2.23822031
11MP0005076_abnormal_cell_differentiation2.17035529
12MP0003300_gastrointestinal_ulcer2.09202280
13MP0006054_spinal_hemorrhage2.06789610
14MP0002877_abnormal_melanocyte_morpholog2.06329163
15MP0005623_abnormal_meninges_morphology2.00972831
16MP0009053_abnormal_anal_canal2.00211309
17MP0010234_abnormal_vibrissa_follicle1.99684346
18MP0004272_abnormal_basement_membrane1.98348760
19MP0010030_abnormal_orbit_morphology1.96433333
20MP0000537_abnormal_urethra_morphology1.93972794
21MP0003566_abnormal_cell_adhesion1.93357914
22MP0003279_aneurysm1.88991679
23MP0002139_abnormal_hepatobiliary_system1.85224500
24MP0005058_abnormal_lysosome_morphology1.82290894
25MP0005220_abnormal_exocrine_pancreas1.79768780
26MP0004233_abnormal_muscle_weight1.76670830
27MP0009384_cardiac_valve_regurgitation1.71145629
28MP0003436_decreased_susceptibility_to1.68101734
29MP0000013_abnormal_adipose_tissue1.67934966
30MP0005365_abnormal_bile_salt1.64985064
31MP0005409_darkened_coat_color1.61026215
32MP0003252_abnormal_bile_duct1.59593299
33MP0002896_abnormal_bone_mineralization1.57374126
34MP0005360_urolithiasis1.54737808
35MP0005023_abnormal_wound_healing1.54533982
36MP0001958_emphysema1.50206189
37MP0000003_abnormal_adipose_tissue1.45013557
38MP0005083_abnormal_biliary_tract1.44749633
39MP0000858_altered_metastatic_potential1.44446132
40MP0002089_abnormal_postnatal_growth/wei1.43149554
41MP0000733_abnormal_muscle_development1.41914355
42MP0004947_skin_inflammation1.41030022
43MP0003942_abnormal_urinary_system1.39133191
44MP0008260_abnormal_autophagy1.38753799
45MP0003115_abnormal_respiratory_system1.34817346
46MP0003091_abnormal_cell_migration1.34174065
47MP0005257_abnormal_intraocular_pressure1.33123571
48MP0001348_abnormal_lacrimal_gland1.32442070
49MP0000534_abnormal_ureter_morphology1.31062599
50MP0010368_abnormal_lymphatic_system1.30198187
51MP0008961_abnormal_basal_metabolism1.29577058
52MP0002166_altered_tumor_susceptibility1.29226959
53MP0002909_abnormal_adrenal_gland1.28674989
54MP0003123_paternal_imprinting1.26873405
55MP0003453_abnormal_keratinocyte_physiol1.26615455
56MP0002796_impaired_skin_barrier1.24609031
57MP0003183_abnormal_peptide_metabolism1.24318493
58MP0001666_abnormal_nutrient_absorption1.24252733
59MP0004858_abnormal_nervous_system1.15652947
60MP0001299_abnormal_eye_distance/1.15557834
61MP0005375_adipose_tissue_phenotype1.14120798
62MP0004185_abnormal_adipocyte_glucose1.09844421
63MP0003385_abnormal_body_wall1.09731054
64MP0005248_abnormal_Harderian_gland1.09295065
65MP0001849_ear_inflammation1.09262672
66MP0000428_abnormal_craniofacial_morphol1.08438629
67MP0010329_abnormal_lipoprotein_level1.08136911
68MP0002998_abnormal_bone_remodeling1.07640820
69MP0005508_abnormal_skeleton_morphology1.07032994
70MP0001944_abnormal_pancreas_morphology1.06552108
71MP0000750_abnormal_muscle_regeneration1.05982234
72MP0001533_abnormal_skeleton_physiology1.05776973
73MP0002234_abnormal_pharynx_morphology1.05184304
74MP0004130_abnormal_muscle_cell1.04170349
75MP0005085_abnormal_gallbladder_physiolo1.02697995
76MP0005164_abnormal_response_to1.02394218
77MP0004197_abnormal_fetal_growth/weight/1.01456340
78MP0002396_abnormal_hematopoietic_system1.00986877
79MP0009672_abnormal_birth_weight1.00700313
80MP0004782_abnormal_surfactant_physiolog0.99764904
81MP0010155_abnormal_intestine_physiology0.99482308
82MP0005666_abnormal_adipose_tissue0.98547300
83MP0002060_abnormal_skin_morphology0.95230415
84MP0004264_abnormal_extraembryonic_tissu0.93367983
85MP0003119_abnormal_digestive_system0.93006861
86MP0000685_abnormal_immune_system0.92802763
87MP0001873_stomach_inflammation0.92544952
88MP0003122_maternal_imprinting0.92339640
89MP0000163_abnormal_cartilage_morphology0.89431077
90MP0002932_abnormal_joint_morphology0.88662440
91MP0000678_abnormal_parathyroid_gland0.87978336
92MP0004087_abnormal_muscle_fiber0.86504941
93MP0003959_abnormal_lean_body0.86102007
94MP0005187_abnormal_penis_morphology0.85314692
95MP0002697_abnormal_eye_size0.83766983
96MP0004808_abnormal_hematopoietic_stem0.83233856
97MP0000627_abnormal_mammary_gland0.82810829
98MP0005501_abnormal_skin_physiology0.82576831
99MP0004883_abnormal_blood_vessel0.81883161
100MP0003075_altered_response_to0.81079124
101MP0005621_abnormal_cell_physiology0.80662307
102MP0001915_intracranial_hemorrhage0.80311622
103MP0002115_abnormal_skeleton_extremities0.79540251
104MP0003828_pulmonary_edema0.78788075
105MP0002295_abnormal_pulmonary_circulatio0.78694036
106MP0000767_abnormal_smooth_muscle0.78460936
107MP0002269_muscular_atrophy0.78230738
108MP0005464_abnormal_platelet_physiology0.76543067
109MP0003724_increased_susceptibility_to0.76503679
110MP0002419_abnormal_innate_immunity0.76123153
111MP0005390_skeleton_phenotype0.75901760
112MP0003303_peritoneal_inflammation0.75735769
113MP0010307_abnormal_tumor_latency0.75657379
114MP0003329_amyloid_beta_deposits0.75653135
115MP0006138_congestive_heart_failure0.74926972
116MP0002084_abnormal_developmental_patter0.74678293
117MP0002108_abnormal_muscle_morphology0.74473734
118MP0010630_abnormal_cardiac_muscle0.73769656
119MP0000598_abnormal_liver_morphology0.73625427
120MP0002009_preneoplasia0.72711460
121MP0002006_tumorigenesis0.72013892
122MP0003868_abnormal_feces_composition0.71867494
123MP0003448_altered_tumor_morphology0.71865898
124MP0002282_abnormal_trachea_morphology0.70997650
125MP0003172_abnormal_lysosome_physiology0.70801084
126MP0000751_myopathy0.70493742
127MP0001243_abnormal_dermal_layer0.69551529
128MP0000609_abnormal_liver_physiology0.69472636
129MP0002111_abnormal_tail_morphology0.69001581
130MP0009278_abnormal_bone_marrow0.68996154
131MP0002086_abnormal_extraembryonic_tissu0.68976329
132MP0002168_other_aberrant_phenotype0.68809486
133MP0003941_abnormal_skin_development0.68700288
134MP0002088_abnormal_embryonic_growth/wei0.68516649
135MP0000249_abnormal_blood_vessel0.68455406
136MP0001730_embryonic_growth_arrest0.68003504
137MP0009931_abnormal_skin_appearance0.67817456
138MP0001756_abnormal_urination0.67331014
139MP0001216_abnormal_epidermal_layer0.67328235
140MP0003984_embryonic_growth_retardation0.66974768
141MP0002113_abnormal_skeleton_development0.66787658
142MP0002928_abnormal_bile_duct0.66399985
143MP0001542_abnormal_bone_strength0.66252662
144MP0002925_abnormal_cardiovascular_devel0.65885524
145MP0003045_fibrosis0.65881645
146MP0001614_abnormal_blood_vessel0.65251088
147MP0000477_abnormal_intestine_morphology0.64651635

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.81635361
2Premature rupture of membranes (HP:0001788)4.44815219
3Shallow orbits (HP:0000586)3.97619702
4Cerebral aneurysm (HP:0004944)3.67539794
5Cervical subluxation (HP:0003308)3.32925368
6Ankle contracture (HP:0006466)3.25801075
7Flat acetabular roof (HP:0003180)3.18788281
8Aortic aneurysm (HP:0004942)3.13512599
9Aortic dissection (HP:0002647)3.06497766
10Peritonitis (HP:0002586)3.00981082
11Asymmetry of the thorax (HP:0001555)2.97394592
12Dilatation of the ascending aorta (HP:0005111)2.95035739
13Upper limb amyotrophy (HP:0009129)2.88788032
14Distal upper limb amyotrophy (HP:0007149)2.88788032
15Bladder diverticulum (HP:0000015)2.88263091
16Hand muscle atrophy (HP:0009130)2.85919522
17Mitral valve prolapse (HP:0001634)2.78563082
18Genu recurvatum (HP:0002816)2.74032800
19Broad face (HP:0000283)2.72172758
20Aneurysm (HP:0002617)2.72107993
21Lymphangioma (HP:0100764)2.64724086
22Bowel diverticulosis (HP:0005222)2.63433799
23Long toe (HP:0010511)2.62413623
24Broad metatarsal (HP:0001783)2.56726640
25Atrophic scars (HP:0001075)2.56258031
26Abnormality of monocarboxylic acid metabolism (HP:0010996)2.51861738
27Hemorrhage of the eye (HP:0011885)2.49434857
28Enlarged penis (HP:0000040)2.45279120
29Fragile skin (HP:0001030)2.45258334
30Soft skin (HP:0000977)2.43578788
31Blue sclerae (HP:0000592)2.40579771
32Deep venous thrombosis (HP:0002625)2.40292222
33Deviation of the hallux (HP:0010051)2.39145855
34Short nail (HP:0001799)2.38812418
35Hallux valgus (HP:0001822)2.33957934
36Increased density of long bones (HP:0006392)2.33278751
37Hyperacusis (HP:0010780)2.31323919
38Abnormality of carpal bone ossification (HP:0006257)2.30209095
39Back pain (HP:0003418)2.29073582
40Thin bony cortex (HP:0002753)2.28849065
41Osteolytic defects of the hand bones (HP:0009699)2.27916682
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.27916682
43Renal duplication (HP:0000075)2.24342925
44Turricephaly (HP:0000262)2.23091133
45Abnormality of the Achilles tendon (HP:0005109)2.22952704
46Mitral stenosis (HP:0001718)2.22638168
47Achilles tendon contracture (HP:0001771)2.22467436
48Sparse lateral eyebrow (HP:0005338)2.21848348
49Increased variability in muscle fiber diameter (HP:0003557)2.21264419
50Disproportionate tall stature (HP:0001519)2.21234905
51Abnormal ossification of hand bones (HP:0005921)2.20430323
52Wrist flexion contracture (HP:0001239)2.19861089
53Radial bowing (HP:0002986)2.15246318
54Buphthalmos (HP:0000557)2.13576251
55Striae distensae (HP:0001065)2.09120162
56Spinal cord lesions (HP:0100561)2.07910580
57Syringomyelia (HP:0003396)2.07910580
58Obstructive sleep apnea (HP:0002870)2.07634831
59Subacute progressive viral hepatitis (HP:0006572)2.06479959
60Increased connective tissue (HP:0009025)2.06121763
61Hyperextensible skin (HP:0000974)2.05174821
62Wormian bones (HP:0002645)2.04794777
63Biconcave vertebral bodies (HP:0004586)2.03896318
64Congenital glaucoma (HP:0001087)2.03114972
65Distal lower limb amyotrophy (HP:0008944)2.03045524
66Vertebral compression fractures (HP:0002953)2.02856138
67Abnormality of complement system (HP:0005339)2.02234276
68Mitral regurgitation (HP:0001653)1.99959215
69Abnormality of skeletal muscle fiber size (HP:0012084)1.98925185
70Abnormality of dentin (HP:0010299)1.97331289
71Macroorchidism (HP:0000053)1.97075143
72Abnormality of the distal phalanges of the toes (HP:0010182)1.96935340
73Camptodactyly of toe (HP:0001836)1.96661602
74Distal lower limb muscle weakness (HP:0009053)1.96377604
75Exostoses (HP:0100777)1.94036622
76Abnormality of the acetabulum (HP:0003170)1.93906411
77Coxa vara (HP:0002812)1.93434128
78Spinal rigidity (HP:0003306)1.92400227
79Joint laxity (HP:0001388)1.92245912
80Type 1 muscle fiber predominance (HP:0003803)1.92062508
81Overgrowth (HP:0001548)1.91860160
82Spastic diplegia (HP:0001264)1.91613682
83Abnormality of the distal phalanx of the thumb (HP:0009617)1.89200118
84Spondylolisthesis (HP:0003302)1.88042398
85Ectopia lentis (HP:0001083)1.87999782
86Abnormality of the calcaneus (HP:0008364)1.87697678
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87598897
88Short 4th metacarpal (HP:0010044)1.87598897
89Ankyloglossia (HP:0010296)1.87404516
90Mildly elevated creatine phosphokinase (HP:0008180)1.85524181
91Advanced eruption of teeth (HP:0006288)1.84687531
92Cupped ribs (HP:0000887)1.84115438
93Osteopenia (HP:0000938)1.84113039
94Eczematoid dermatitis (HP:0000976)1.82283832
95Abnormality of the 4th metacarpal (HP:0010012)1.81993151
96Abnormality of the lower motor neuron (HP:0002366)1.81311718
97Cardiovascular calcification (HP:0011915)1.80645575
98Urinary glycosaminoglycan excretion (HP:0003541)1.78498384
99Mucopolysacchariduria (HP:0008155)1.78498384
100Hypercortisolism (HP:0001578)1.77683770
101Neonatal short-limb short stature (HP:0008921)1.77017880
102Bowing of the arm (HP:0006488)1.76136010
103Bowed forearm bones (HP:0003956)1.76136010
104Abnormality of oral frenula (HP:0000190)1.76058626
105Skin nodule (HP:0200036)1.75963499
106Spinal cord compression (HP:0002176)1.75615402
107Dysostosis multiplex (HP:0000943)1.75000555
108Centrally nucleated skeletal muscle fibers (HP:0003687)1.74428945
109Difficulty climbing stairs (HP:0003551)1.73910451
110Aortic regurgitation (HP:0001659)1.72297859
111J-shaped sella turcica (HP:0002680)1.71676996
112Severe short stature (HP:0003510)1.71542304
113Rectal prolapse (HP:0002035)1.71269524
114Long palpebral fissure (HP:0000637)1.71059836
115Ulnar bowing (HP:0003031)1.70923126
116Renovascular hypertension (HP:0100817)1.69797381
117Elfin facies (HP:0004428)1.69081880
118Abnormal hand bone ossification (HP:0010660)1.68916111
119Papilledema (HP:0001085)1.67331416
120Abnormality of the intrinsic pathway (HP:0010989)1.67186939
121Interstitial pulmonary disease (HP:0006530)1.67049402
122Vascular tortuosity (HP:0004948)1.66013938
123Segmental peripheral demyelination/remyelination (HP:0003481)1.65718854
124Fibroma (HP:0010614)1.64828056
125Hypoglycemic coma (HP:0001325)1.64794926
126Scapular winging (HP:0003691)1.64629878
127Malnutrition (HP:0004395)1.64280453
128Absent frontal sinuses (HP:0002688)1.64146291
129Polygenic inheritance (HP:0010982)1.64105246
130Elbow flexion contracture (HP:0002987)1.63550865
131Complement deficiency (HP:0004431)1.62921286
132Cellulitis (HP:0100658)1.62524293
133Abnormality of mucopolysaccharide metabolism (HP:0011020)1.62187600
134Abnormality of polysaccharide metabolism (HP:0011012)1.62187600
135Abnormality of glycosaminoglycan metabolism (HP:0004371)1.62187600
136Ketoacidosis (HP:0001993)1.61658408
137Abnormality of the common coagulation pathway (HP:0010990)1.61170622
138Myocardial infarction (HP:0001658)1.59176607
139Abnormality of the thoracic spine (HP:0100711)1.58187479
140Vascular calcification (HP:0004934)1.57694150
141Ovoid vertebral bodies (HP:0003300)1.57608927
142Xanthomatosis (HP:0000991)1.56230327
143Angiofibromas (HP:0010615)1.55540495
144Adenoma sebaceum (HP:0009720)1.55540495
145Wide anterior fontanel (HP:0000260)1.55488177
146Arterial tortuosity (HP:0005116)1.55238700
147Bronchomalacia (HP:0002780)1.55151964
148Abnormal cartilage morphology (HP:0002763)1.55102673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.48740919
2PKN24.54169361
3ERN13.90366909
4EEF2K2.84762667
5PDGFRA2.55803743
6PRPF4B2.54555879
7SMG12.45737771
8RIPK12.45355195
9TTN2.40364258
10LATS22.33545321
11SCYL22.33259189
12DDR22.33126458
13LATS12.31808484
14SIK12.31115274
15IRAK32.10390445
16NEK12.06155078
17PTK62.01899064
18PRKD31.86961439
19MAP3K101.82477672
20BCKDK1.64306362
21EPHB11.63836546
22TESK11.57145167
23PAK21.56895380
24PTK21.54804316
25MST1R1.50367081
26LRRK21.44275799
27AKT31.42965919
28PRKD21.39759242
29BMX1.38730556
30FLT31.34481810
31MAP3K31.33862791
32CAMKK11.33529235
33PAK41.29214264
34EPHA21.27932300
35MTOR1.21541081
36MAP3K131.14811142
37CAMK1D1.10800775
38EPHB21.10687407
39FER1.09878878
40KSR21.08314528
41PDPK11.08122851
42RET1.08030633
43ICK1.04814604
44TAOK11.04503654
45MARK21.03718454
46TESK21.03122615
47FRK1.00810913
48FGFR10.95495622
49PAK60.95215107
50NTRK10.94417398
51ALK0.94338726
52PAK30.93869494
53IRAK40.93831732
54DMPK0.92927862
55PASK0.92700103
56TYK20.90150872
57ZAP700.89979592
58ILK0.89209512
59CDK120.86949574
60TBK10.84122535
61FGFR30.83727391
62MAP3K90.83592908
63KSR10.80515247
64MYLK0.80128874
65RIPK40.77365567
66CAMK1G0.75567280
67RPS6KA40.73918796
68CDK60.73478459
69MAPKAPK30.72890513
70DYRK1B0.72741651
71MAP3K20.72154298
72MAP2K10.71415322
73TNK20.70735616
74MAP3K140.70681749
75GRK60.69562268
76PDGFRB0.68841381
77FGFR40.67902251
78LIMK10.67434907
79MAPK110.65758764
80MINK10.65370321
81HIPK20.65169666
82RPS6KL10.64647002
83RPS6KC10.64647002
84MAP3K60.62703462
85MAP2K20.62649022
86PDK10.62257895
87MAP3K80.61823088
88STK380.61616230
89TGFBR20.60663195
90MET0.59821807
91LMTK20.57676800
92PRKCH0.57300473
93NEK90.57267370
94CDK70.57071614
95TRPM70.56475462
96JAK10.55597875
97IRAK20.55558033
98ERBB20.55180345
99NME20.52595881
100TGFBR10.52511676
101RPS6KB20.52257381
102MELK0.51701854
103STK30.51417474
104RPS6KA20.50778923
105MAP4K10.50228058
106MAP3K70.47544890
107MAPKAPK20.47482525
108SGK30.46206132
109DAPK30.45683322
110NEK20.44880666
111CSK0.44597271
112RPS6KA60.43705564
113CDC42BPA0.43659609
114CDK140.43170085
115JAK30.43025479
116ROCK10.42608279
117CDK150.40839994
118DAPK20.40289898
119TYRO30.39432982
120TAOK20.38488199
121CDK180.37232116
122MAP3K110.36779721
123SIK30.35461044
124YES10.35055477
125CDK11A0.33959865
126CHUK0.33770165
127WNK10.33579244
128ERBB30.33456446
129PAK10.33116322
130SRC0.32888393
131MAP2K30.32877247
132PRKAA20.32797288
133TAOK30.32341376
134BRSK10.32214086
135PIK3CG0.31987581
136MOS0.30532152
137AKT20.30302956
138MAP3K10.29744165
139PRKD10.29511718
140PTK2B0.29061072
141PDK30.28841990
142PDK40.28841990
143STK38L0.27753480
144PRKG20.27222450
145CAMKK20.26995250
146ABL20.23560930

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.72282013
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.17496488
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.16384481
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.10389645
5Other glycan degradation_Homo sapiens_hsa005112.08650131
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.06047766
7Bladder cancer_Homo sapiens_hsa052191.83912873
8Acute myeloid leukemia_Homo sapiens_hsa052211.77962319
9Selenocompound metabolism_Homo sapiens_hsa004501.75511001
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69170007
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.60538325
12Focal adhesion_Homo sapiens_hsa045101.59502664
13Biosynthesis of amino acids_Homo sapiens_hsa012301.58441079
14Arginine biosynthesis_Homo sapiens_hsa002201.52258705
15Proteoglycans in cancer_Homo sapiens_hsa052051.50739095
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49959352
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49772364
18Fructose and mannose metabolism_Homo sapiens_hsa000511.46314267
19ECM-receptor interaction_Homo sapiens_hsa045121.46156401
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.45945359
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.45038488
22Fatty acid degradation_Homo sapiens_hsa000711.44888210
23Protein digestion and absorption_Homo sapiens_hsa049741.42295506
24Chronic myeloid leukemia_Homo sapiens_hsa052201.38631902
25Carbon metabolism_Homo sapiens_hsa012001.34109276
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.33358871
27N-Glycan biosynthesis_Homo sapiens_hsa005101.32543374
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30124090
29Notch signaling pathway_Homo sapiens_hsa043301.29989764
30mTOR signaling pathway_Homo sapiens_hsa041501.28090850
31Renal cell carcinoma_Homo sapiens_hsa052111.28011809
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26002083
33Adherens junction_Homo sapiens_hsa045201.25457012
34Prostate cancer_Homo sapiens_hsa052151.24151813
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22685293
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21965829
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20761291
38Glioma_Homo sapiens_hsa052141.20719083
39Phenylalanine metabolism_Homo sapiens_hsa003601.20170669
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18486692
41One carbon pool by folate_Homo sapiens_hsa006701.16435511
42B cell receptor signaling pathway_Homo sapiens_hsa046621.15257525
43Endometrial cancer_Homo sapiens_hsa052131.14581386
44Hepatitis C_Homo sapiens_hsa051601.14360669
45Hippo signaling pathway_Homo sapiens_hsa043901.12119026
46Lysine degradation_Homo sapiens_hsa003101.10874931
47Pentose phosphate pathway_Homo sapiens_hsa000301.09715886
48Insulin resistance_Homo sapiens_hsa049311.08691211
49Small cell lung cancer_Homo sapiens_hsa052221.06731048
50Tryptophan metabolism_Homo sapiens_hsa003801.05588087
51Fatty acid metabolism_Homo sapiens_hsa012121.03575983
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03439974
53AMPK signaling pathway_Homo sapiens_hsa041521.02861403
54Amoebiasis_Homo sapiens_hsa051461.02367568
55Osteoclast differentiation_Homo sapiens_hsa043801.01581447
56Fat digestion and absorption_Homo sapiens_hsa049751.01492578
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01060240
58Insulin signaling pathway_Homo sapiens_hsa049101.01024942
59Bile secretion_Homo sapiens_hsa049761.00428357
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95514415
61PPAR signaling pathway_Homo sapiens_hsa033200.95419381
62TNF signaling pathway_Homo sapiens_hsa046680.92671657
63Choline metabolism in cancer_Homo sapiens_hsa052310.92226245
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.91539784
65ErbB signaling pathway_Homo sapiens_hsa040120.90431907
66Glucagon signaling pathway_Homo sapiens_hsa049220.88782843
67Fatty acid biosynthesis_Homo sapiens_hsa000610.87057141
68Pyruvate metabolism_Homo sapiens_hsa006200.86140686
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86044040
70Hepatitis B_Homo sapiens_hsa051610.85233927
71Type II diabetes mellitus_Homo sapiens_hsa049300.84869247
72Toxoplasmosis_Homo sapiens_hsa051450.83123694
73Estrogen signaling pathway_Homo sapiens_hsa049150.82840410
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.82747479
75MicroRNAs in cancer_Homo sapiens_hsa052060.82733998
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82586421
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82396529
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.81664953
79Non-small cell lung cancer_Homo sapiens_hsa052230.81440662
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80022488
81Histidine metabolism_Homo sapiens_hsa003400.79813823
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79372104
83Basal cell carcinoma_Homo sapiens_hsa052170.79355022
84Thyroid cancer_Homo sapiens_hsa052160.78897359
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78068451
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77910692
87Pancreatic cancer_Homo sapiens_hsa052120.77640250
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77569317
89Propanoate metabolism_Homo sapiens_hsa006400.77177040
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.77112179
91Dilated cardiomyopathy_Homo sapiens_hsa054140.75036516
92Starch and sucrose metabolism_Homo sapiens_hsa005000.74925597
93Galactose metabolism_Homo sapiens_hsa000520.72694886
94Thyroid hormone synthesis_Homo sapiens_hsa049180.72495257
95GnRH signaling pathway_Homo sapiens_hsa049120.72022947
96Colorectal cancer_Homo sapiens_hsa052100.71629209
97Endocytosis_Homo sapiens_hsa041440.71424599
98Renin-angiotensin system_Homo sapiens_hsa046140.70742684
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70712247
100Butanoate metabolism_Homo sapiens_hsa006500.70396349
101Influenza A_Homo sapiens_hsa051640.70367118
102Apoptosis_Homo sapiens_hsa042100.70172692
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69506654
104Complement and coagulation cascades_Homo sapiens_hsa046100.68956934
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67984396
106Prion diseases_Homo sapiens_hsa050200.66808358
107Platelet activation_Homo sapiens_hsa046110.66776134
108Vitamin digestion and absorption_Homo sapiens_hsa049770.66328329
109VEGF signaling pathway_Homo sapiens_hsa043700.64765018
110Leishmaniasis_Homo sapiens_hsa051400.64033196
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63991354
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63889359
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62551424
114Staphylococcus aureus infection_Homo sapiens_hsa051500.62195707
115FoxO signaling pathway_Homo sapiens_hsa040680.62185397
116Inositol phosphate metabolism_Homo sapiens_hsa005620.61739118
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.61672583
118Tight junction_Homo sapiens_hsa045300.61670572
119HIF-1 signaling pathway_Homo sapiens_hsa040660.61567123
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61088788
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.60255185
122Sulfur relay system_Homo sapiens_hsa041220.59404302
123Melanoma_Homo sapiens_hsa052180.59173535
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58272461
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57849320
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57285225
127TGF-beta signaling pathway_Homo sapiens_hsa043500.56972480
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56647992
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.56052881
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55889557
131Pancreatic secretion_Homo sapiens_hsa049720.54920624
132Malaria_Homo sapiens_hsa051440.54242170
133Sulfur metabolism_Homo sapiens_hsa009200.53665747
134Tyrosine metabolism_Homo sapiens_hsa003500.52940901
135Gap junction_Homo sapiens_hsa045400.52917759
136Prolactin signaling pathway_Homo sapiens_hsa049170.51556604
137Hedgehog signaling pathway_Homo sapiens_hsa043400.50675601
138Lysosome_Homo sapiens_hsa041420.49909521
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49012436
140Pathways in cancer_Homo sapiens_hsa052000.48840725
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.48765148
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48719015
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48622387
144Measles_Homo sapiens_hsa051620.48452016

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