ERGIC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ERGIC2, or PTX1, is a ubiquitously expressed nuclear protein that is downregulated in prostate carcinoma (Kwok et al., 2001 [PubMed 11445006]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)5.53104819
2cullin deneddylation (GO:0010388)4.71931739
3protein deneddylation (GO:0000338)4.70344969
4CENP-A containing nucleosome assembly (GO:0034080)4.49807636
5piRNA metabolic process (GO:0034587)4.43154459
6chromatin remodeling at centromere (GO:0031055)4.36260216
7attachment of spindle microtubules to kinetochore (GO:0008608)4.35725221
8protein neddylation (GO:0045116)4.34272706
9proteasome assembly (GO:0043248)3.84627577
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.84217184
11kinetochore organization (GO:0051383)3.83011645
127-methylguanosine mRNA capping (GO:0006370)3.75596813
13COPI coating of Golgi vesicle (GO:0048205)3.73123490
14Golgi transport vesicle coating (GO:0048200)3.73123490
15histone exchange (GO:0043486)3.72663030
16RNA capping (GO:0036260)3.66524681
177-methylguanosine RNA capping (GO:0009452)3.66524681
18regulation of metalloenzyme activity (GO:0048552)3.65697415
19mitotic metaphase plate congression (GO:0007080)3.65496450
20DNA methylation involved in gamete generation (GO:0043046)3.59938571
21kinetochore assembly (GO:0051382)3.57457297
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52176539
23DNA replication-independent nucleosome organization (GO:0034724)3.51681900
24DNA replication-independent nucleosome assembly (GO:0006336)3.51681900
25regulation of DNA endoreduplication (GO:0032875)3.50794122
26respiratory chain complex IV assembly (GO:0008535)3.50232952
27ribosome assembly (GO:0042255)3.49582630
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.46653528
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45930376
30DNA catabolic process, exonucleolytic (GO:0000738)3.45413136
31regulation of cellular amino acid metabolic process (GO:0006521)3.36175621
32purine nucleobase biosynthetic process (GO:0009113)3.35643701
33anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34804214
34somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.32769125
35somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.32769125
36isotype switching (GO:0045190)3.32769125
37maturation of 5.8S rRNA (GO:0000460)3.32476775
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27994955
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26357367
40regulation of mitotic spindle checkpoint (GO:1903504)3.24040382
41regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24040382
42metaphase plate congression (GO:0051310)3.23100365
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22972118
44establishment of integrated proviral latency (GO:0075713)3.22698857
45replication fork processing (GO:0031297)3.22655646
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.22004494
47DNA damage response, detection of DNA damage (GO:0042769)3.21085135
48negative regulation of DNA-dependent DNA replication (GO:2000104)3.20292323
49DNA replication checkpoint (GO:0000076)3.20204307
50ER overload response (GO:0006983)3.19565016
51intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.18888243
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.18888243
53signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.18526039
54signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.18526039
55signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.18526039
56rRNA modification (GO:0000154)3.17643131
57DNA double-strand break processing (GO:0000729)3.14988620
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.14737865
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14348116
60L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.13096154
61negative regulation of ligase activity (GO:0051352)3.13073808
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13073808
63rRNA methylation (GO:0031167)3.12353431
64antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.10329266
65mitochondrial respiratory chain complex I assembly (GO:0032981)3.10088279
66NADH dehydrogenase complex assembly (GO:0010257)3.10088279
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10088279
68transcription elongation from RNA polymerase I promoter (GO:0006362)3.09520168
69deoxyribonucleotide biosynthetic process (GO:0009263)3.09423878
70signal transduction involved in DNA damage checkpoint (GO:0072422)3.07679490
71signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07679490
72establishment of protein localization to mitochondrial membrane (GO:0090151)3.07322172
73nucleobase biosynthetic process (GO:0046112)3.07051112
74signal transduction involved in cell cycle checkpoint (GO:0072395)3.06703889
75organelle disassembly (GO:1903008)3.06450801
76transcription-coupled nucleotide-excision repair (GO:0006283)3.05826125
77DNA deamination (GO:0045006)3.05717062
78antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.05712776
79transcription elongation from RNA polymerase II promoter (GO:0006368)3.04946053
80establishment of chromosome localization (GO:0051303)3.04763931
81water-soluble vitamin biosynthetic process (GO:0042364)3.04157342
82establishment of viral latency (GO:0019043)3.03523383
83DNA ligation (GO:0006266)3.02640152
84microtubule depolymerization (GO:0007019)3.01694691
85positive regulation of ligase activity (GO:0051351)3.00293472
86protein complex biogenesis (GO:0070271)2.98732971
87viral mRNA export from host cell nucleus (GO:0046784)2.95853232
88regulation of centriole replication (GO:0046599)2.93759411
89protein-cofactor linkage (GO:0018065)2.93207473
90male meiosis (GO:0007140)2.91878229
91monoubiquitinated protein deubiquitination (GO:0035520)2.91088460
92preassembly of GPI anchor in ER membrane (GO:0016254)2.90666411
93telomere maintenance via recombination (GO:0000722)2.90617441
94regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.90074789
95termination of RNA polymerase I transcription (GO:0006363)2.89979969
96energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89843998
97ATP synthesis coupled proton transport (GO:0015986)2.89843998
98postreplication repair (GO:0006301)2.89325330
99spindle checkpoint (GO:0031577)2.89229090
100mitotic recombination (GO:0006312)2.89112490
101transcription elongation from RNA polymerase III promoter (GO:0006385)2.88960649
102termination of RNA polymerase III transcription (GO:0006386)2.88960649
103nucleotide transmembrane transport (GO:1901679)2.87820214
104cytochrome complex assembly (GO:0017004)2.85226074
105negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84273978
106response to X-ray (GO:0010165)2.83700016
107regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.83611621
108RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83177804
109deoxyribose phosphate biosynthetic process (GO:0046385)2.82957368
1102-deoxyribonucleotide biosynthetic process (GO:0009265)2.82957368
111histone mRNA metabolic process (GO:0008334)2.82922344
112COPII vesicle coating (GO:0048208)2.82451214
113DNA-templated transcription, elongation (GO:0006354)2.81730915
114transcription from RNA polymerase I promoter (GO:0006360)2.81331454
115meiotic chromosome segregation (GO:0045132)2.80944744
116mitotic sister chromatid cohesion (GO:0007064)2.80044312
117regulation of glucokinase activity (GO:0033131)2.79999779
118regulation of hexokinase activity (GO:1903299)2.79999779
119protein localization to kinetochore (GO:0034501)2.78443760
120ribonucleoprotein complex disassembly (GO:0032988)2.77803728
121somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76752454
122somatic hypermutation of immunoglobulin genes (GO:0016446)2.76752454
123mitochondrial respiratory chain complex assembly (GO:0033108)2.76652975
124transcription initiation from RNA polymerase I promoter (GO:0006361)2.76295319
125protein K6-linked ubiquitination (GO:0085020)2.75021623
126regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.74478972
127negative regulation of mitotic sister chromatid separation (GO:2000816)2.74441018
128negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74441018
129negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74441018
130negative regulation of sister chromatid segregation (GO:0033046)2.74441018
131regulation of ubiquitin-protein transferase activity (GO:0051438)2.73549080
132double-strand break repair via nonhomologous end joining (GO:0006303)2.73436605
133non-recombinational repair (GO:0000726)2.73436605
134protein K11-linked ubiquitination (GO:0070979)2.73162551
135recombinational repair (GO:0000725)2.73073215
136maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72122421
137cell cycle G1/S phase transition (GO:0044843)2.71268013
138G1/S transition of mitotic cell cycle (GO:0000082)2.71268013
139chaperone-mediated protein transport (GO:0072321)2.70446232
140double-strand break repair via homologous recombination (GO:0000724)2.68845959
141resolution of meiotic recombination intermediates (GO:0000712)2.68649141
142somatic recombination of immunoglobulin gene segments (GO:0016447)2.68540225
143nucleotide-excision repair, DNA gap filling (GO:0006297)2.67708767
144chromosome segregation (GO:0007059)2.66905849
145platelet dense granule organization (GO:0060155)2.66889770
146pseudouridine synthesis (GO:0001522)2.63509390
147regulation of acyl-CoA biosynthetic process (GO:0050812)2.57110561
148synapsis (GO:0007129)2.56676968
149maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.54675367

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.78882719
2E2F7_22180533_ChIP-Seq_HELA_Human4.06736485
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.71110192
4* EST1_17652178_ChIP-ChIP_JURKAT_Human3.29083921
5CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88492431
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84872518
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.84658894
8* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63443257
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.61008878
10* ELK1_19687146_ChIP-ChIP_HELA_Human2.56155778
11PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.49363662
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.40418181
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33002081
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.30586503
15ZNF274_21170338_ChIP-Seq_K562_Hela2.30309254
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26993099
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24598123
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23006124
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.20814649
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.16196666
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12101510
22* VDR_23849224_ChIP-Seq_CD4+_Human2.10052097
23DCP1A_22483619_ChIP-Seq_HELA_Human2.05352885
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.05319823
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02891829
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01461158
27FUS_26573619_Chip-Seq_HEK293_Human1.99588422
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.92680620
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92478735
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85303863
31* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78977719
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78360373
33* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77476850
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75843641
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74914300
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.74678848
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73942517
38TAF15_26573619_Chip-Seq_HEK293_Human1.73638064
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71370424
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70305540
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64143387
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63955416
43AR_21909140_ChIP-Seq_LNCAP_Human1.63583756
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62023489
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60830332
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59636746
47EWS_26573619_Chip-Seq_HEK293_Human1.57313639
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57213339
49* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57182362
50FOXP3_21729870_ChIP-Seq_TREG_Human1.55805905
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.53513942
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51426667
53IGF1R_20145208_ChIP-Seq_DFB_Human1.47190482
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46892080
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46661327
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46176449
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45182049
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44949761
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44855357
60GABP_19822575_ChIP-Seq_HepG2_Human1.42139676
61IRF1_19129219_ChIP-ChIP_H3396_Human1.36584111
62VDR_22108803_ChIP-Seq_LS180_Human1.36441311
63ER_23166858_ChIP-Seq_MCF-7_Human1.36342582
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.36296754
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34007121
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32023478
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30647574
68FOXM1_23109430_ChIP-Seq_U2OS_Human1.30521879
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.28146934
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28027866
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27907851
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25870019
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.25537314
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25529290
75* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25198767
76* CBP_20019798_ChIP-Seq_JUKART_Human1.25198767
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24981914
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.23700031
79SMAD4_21799915_ChIP-Seq_A2780_Human1.22391663
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18412168
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18354067
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.17361285
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17017810
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14870440
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.14676598
86MYC_18940864_ChIP-ChIP_HL60_Human1.13343998
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13293215
88BCAT_22108803_ChIP-Seq_LS180_Human1.12820938
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.11804425
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10581791
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.10489413
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10226941
93MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09854301
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09426585
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08048027
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07197998
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.07170524
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07097828
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06617931
100KAP1_22055183_ChIP-Seq_ESCs_Mouse1.04945357
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04154359
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.03315744
103TTF2_22483619_ChIP-Seq_HELA_Human1.03218208
104ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02924085
105XRN2_22483619_ChIP-Seq_HELA_Human1.02753535
106TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02729210
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02421464
108SOX2_19829295_ChIP-Seq_ESCs_Human1.01986824
109NANOG_19829295_ChIP-Seq_ESCs_Human1.01986824
110CDX2_22108803_ChIP-Seq_LS180_Human1.01336961
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00523126
112P300_18555785_Chip-Seq_ESCs_Mouse1.00492602
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.00156069
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00054497
115STAT3_18555785_Chip-Seq_ESCs_Mouse0.99893216
116POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99823284
117EZH2_27294783_Chip-Seq_NPCs_Mouse0.99774900
118AR_25329375_ChIP-Seq_VCAP_Human0.99729496
119ELK1_22589737_ChIP-Seq_MCF10A_Human0.99723574
120P300_19829295_ChIP-Seq_ESCs_Human0.98583602
121GBX2_23144817_ChIP-Seq_PC3_Human0.97796052
122STAT3_23295773_ChIP-Seq_U87_Human0.97231991
123* TCF4_22108803_ChIP-Seq_LS180_Human0.96091636
124* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95856701
125P53_22387025_ChIP-Seq_ESCs_Mouse0.95556536
126PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95365458
127SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94670138
128* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94611594
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94457433
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94438524
131EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93180638
132YY1_21170310_ChIP-Seq_MESCs_Mouse0.92463161
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92030087
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91374148
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.90349252
136SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89504312
137NMYC_18555785_Chip-Seq_ESCs_Mouse0.89146785
138CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88985402

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.79335604
2MP0003693_abnormal_embryo_hatching3.42479031
3MP0000569_abnormal_digit_pigmentation3.19429780
4MP0003950_abnormal_plasma_membrane3.18766081
5MP0010094_abnormal_chromosome_stability3.14065359
6MP0004957_abnormal_blastocyst_morpholog3.06378523
7MP0008058_abnormal_DNA_repair3.06053409
8MP0008057_abnormal_DNA_replication2.86262919
9MP0009697_abnormal_copulation2.74207482
10MP0003718_maternal_effect2.61730635
11MP0003077_abnormal_cell_cycle2.59983369
12MP0005408_hypopigmentation2.48755288
13MP0003123_paternal_imprinting2.40427150
14MP0005171_absent_coat_pigmentation2.28649466
15MP0000427_abnormal_hair_cycle2.09963919
16MP0003111_abnormal_nucleus_morphology2.09835323
17MP0004782_abnormal_surfactant_physiolog2.07973890
18MP0003806_abnormal_nucleotide_metabolis2.02447879
19MP0003941_abnormal_skin_development1.96869775
20MP0002877_abnormal_melanocyte_morpholog1.95663623
21MP0003121_genomic_imprinting1.91041822
22MP0003786_premature_aging1.87995919
23MP0008007_abnormal_cellular_replicative1.87685966
24MP0008932_abnormal_embryonic_tissue1.85241178
25MP0001984_abnormal_olfaction1.83868086
26MP0003890_abnormal_embryonic-extraembry1.79379432
27MP0003186_abnormal_redox_activity1.77777715
28MP0001929_abnormal_gametogenesis1.72174485
29MP0002210_abnormal_sex_determination1.69012053
30MP0000647_abnormal_sebaceous_gland1.65712785
31MP0002837_dystrophic_cardiac_calcinosis1.65390739
32MP0010678_abnormal_skin_adnexa1.64661726
33MP0001542_abnormal_bone_strength1.64025777
34MP0010386_abnormal_urinary_bladder1.61164442
35MP0002234_abnormal_pharynx_morphology1.61101434
36MP0005084_abnormal_gallbladder_morpholo1.59969572
37MP0005360_urolithiasis1.59422528
38MP0003195_calcinosis1.58895559
39MP0002160_abnormal_reproductive_system1.54610673
40MP0004215_abnormal_myocardial_fiber1.53557524
41MP0000383_abnormal_hair_follicle1.53489878
42MP0001764_abnormal_homeostasis1.51823744
43MP0005253_abnormal_eye_physiology1.46551027
44MP0000653_abnormal_sex_gland1.42223905
45MP0000372_irregular_coat_pigmentation1.41861632
46MP0009780_abnormal_chondrocyte_physiolo1.37706122
47MP0005410_abnormal_fertilization1.36846209
48MP0005389_reproductive_system_phenotype1.36670610
49MP0001145_abnormal_male_reproductive1.36171300
50MP0008260_abnormal_autophagy1.35232321
51MP0001119_abnormal_female_reproductive1.34099156
52MP0008438_abnormal_cutaneous_collagen1.34016636
53MP0002876_abnormal_thyroid_physiology1.33701756
54MP0005187_abnormal_penis_morphology1.33492727
55MP0001529_abnormal_vocalization1.33189351
56MP0003937_abnormal_limbs/digits/tail_de1.33179489
57MP0005395_other_phenotype1.31838190
58MP0005220_abnormal_exocrine_pancreas1.31034265
59MP0002751_abnormal_autonomic_nervous1.26932843
60MP0005503_abnormal_tendon_morphology1.25933108
61MP0003787_abnormal_imprinting1.25294399
62MP0002090_abnormal_vision1.22703392
63MP0002233_abnormal_nose_morphology1.21806703
64MP0005551_abnormal_eye_electrophysiolog1.20891563
65MP0003880_abnormal_central_pattern1.20650520
66MP0000678_abnormal_parathyroid_gland1.20624296
67MP0006054_spinal_hemorrhage1.19667268
68MP0002163_abnormal_gland_morphology1.18578502
69MP0001879_abnormal_lymphatic_vessel1.16440345
70MP0001188_hyperpigmentation1.15570390
71MP0003698_abnormal_male_reproductive1.10775068
72MP0002102_abnormal_ear_morphology1.10667191
73MP0002332_abnormal_exercise_endurance1.10540069
74MP0002938_white_spotting1.09030343
75MP0002736_abnormal_nociception_after1.07474433
76MP0010352_gastrointestinal_tract_polyps1.03758120
77MP0008789_abnormal_olfactory_epithelium1.03366912
78MP0003315_abnormal_perineum_morphology1.01573380
79MP0003011_delayed_dark_adaptation1.01423117
80MP0003252_abnormal_bile_duct1.01354952
81MP0000350_abnormal_cell_proliferation1.00359711
82MP0003122_maternal_imprinting0.99963226
83MP0010234_abnormal_vibrissa_follicle0.99861078
84MP0001919_abnormal_reproductive_system0.99566473
85MP0006036_abnormal_mitochondrial_physio0.99442016
86MP0004264_abnormal_extraembryonic_tissu0.99204190
87MP0001666_abnormal_nutrient_absorption0.97663746
88MP0001905_abnormal_dopamine_level0.97412468
89MP0004084_abnormal_cardiac_muscle0.97173414
90MP0002277_abnormal_respiratory_mucosa0.96265650
91MP0009250_abnormal_appendicular_skeleto0.95183483
92MP0001730_embryonic_growth_arrest0.94927801
93MP0001293_anophthalmia0.92823515
94MP0002282_abnormal_trachea_morphology0.91964229
95MP0005174_abnormal_tail_pigmentation0.91757473
96MP0001177_atelectasis0.90756149
97MP0001986_abnormal_taste_sensitivity0.88278573
98MP0004043_abnormal_pH_regulation0.88134559
99MP0001286_abnormal_eye_development0.86776783
100MP0000681_abnormal_thyroid_gland0.86039052
101MP0010307_abnormal_tumor_latency0.84987554
102MP0003705_abnormal_hypodermis_morpholog0.84710049
103MP0004134_abnormal_chest_morphology0.84477542
104MP0000516_abnormal_urinary_system0.84356164
105MP0005367_renal/urinary_system_phenotyp0.84356164
106MP0001697_abnormal_embryo_size0.83242314
107MP0003191_abnormal_cellular_cholesterol0.83226326
108MP0006035_abnormal_mitochondrial_morpho0.82078602
109MP0002132_abnormal_respiratory_system0.81889212
110MP0002161_abnormal_fertility/fecundity0.81640878
111MP0000538_abnormal_urinary_bladder0.81476338
112MP0002638_abnormal_pupillary_reflex0.81253531
113MP0008872_abnormal_physiological_respon0.79785070
114MP0002693_abnormal_pancreas_physiology0.79691179
115MP0008775_abnormal_heart_ventricle0.79588593
116MP0002295_abnormal_pulmonary_circulatio0.79584621
117MP0002928_abnormal_bile_duct0.79141867
118MP0001324_abnormal_eye_pigmentation0.78060628
119MP0000566_synostosis0.77735638
120MP0005499_abnormal_olfactory_system0.77527064
121MP0005394_taste/olfaction_phenotype0.77527064
122MP0005085_abnormal_gallbladder_physiolo0.77336662
123MP0005332_abnormal_amino_acid0.77287255
124MP0006072_abnormal_retinal_apoptosis0.75984471
125MP0005266_abnormal_metabolism0.75662562
126MP0004142_abnormal_muscle_tone0.75562978
127MP0003943_abnormal_hepatobiliary_system0.75366828
128MP0001299_abnormal_eye_distance/0.73787878
129MP0002095_abnormal_skin_pigmentation0.73602708
130MP0000613_abnormal_salivary_gland0.73410933
131MP0005248_abnormal_Harderian_gland0.72101258
132MP0000358_abnormal_cell_content/0.71363709
133MP0005195_abnormal_posterior_eye0.71235868
134MP0005646_abnormal_pituitary_gland0.71175769
135MP0003755_abnormal_palate_morphology0.70658793
136MP0003283_abnormal_digestive_organ0.70583259
137MP0003868_abnormal_feces_composition0.70155775
138MP0005391_vision/eye_phenotype0.69391226
139MP0006292_abnormal_olfactory_placode0.68422603
140MP0005379_endocrine/exocrine_gland_phen0.67770092
141MP0003221_abnormal_cardiomyocyte_apopto0.67310200
142MP0002009_preneoplasia0.66808815
143MP0002177_abnormal_outer_ear0.65218775
144MP0001186_pigmentation_phenotype0.65149084
145MP0003567_abnormal_fetal_cardiomyocyte0.64127643
146MP0003136_yellow_coat_color0.63774095

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.33731917
2Acute necrotizing encephalopathy (HP:0006965)4.13871064
3Increased serum pyruvate (HP:0003542)3.74707550
4Abnormality of glycolysis (HP:0004366)3.74707550
5Abnormal mitochondria in muscle tissue (HP:0008316)3.62795192
6Breast hypoplasia (HP:0003187)3.59554226
7Progressive macrocephaly (HP:0004481)3.50570832
8Acute encephalopathy (HP:0006846)3.38434365
9Mitochondrial inheritance (HP:0001427)3.18120908
10Methylmalonic acidemia (HP:0002912)3.16499185
11Medial flaring of the eyebrow (HP:0010747)2.94236244
12Increased CSF lactate (HP:0002490)2.92469746
13Irregular epiphyses (HP:0010582)2.92364531
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88207749
15Abnormality of alanine metabolism (HP:0010916)2.88207749
16Hyperalaninemia (HP:0003348)2.88207749
17Volvulus (HP:0002580)2.87493898
18Abnormal spermatogenesis (HP:0008669)2.85314463
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.80714099
20Degeneration of anterior horn cells (HP:0002398)2.72012421
21Abnormality of the anterior horn cell (HP:0006802)2.72012421
22Abnormal hair whorl (HP:0010721)2.71703414
23Abnormality of midbrain morphology (HP:0002418)2.71404307
24Molar tooth sign on MRI (HP:0002419)2.71404307
25Renal cortical cysts (HP:0000803)2.70290284
26Abnormality of the ileum (HP:0001549)2.62474299
27Congenital primary aphakia (HP:0007707)2.61368772
28Carpal bone hypoplasia (HP:0001498)2.54524994
29Hepatocellular necrosis (HP:0001404)2.54408973
30Nephrogenic diabetes insipidus (HP:0009806)2.53959503
31Flat capital femoral epiphysis (HP:0003370)2.53804047
32Gait imbalance (HP:0002141)2.49536631
33Autoamputation (HP:0001218)2.47728246
34Type I transferrin isoform profile (HP:0003642)2.45924260
35Abnormality of the preputium (HP:0100587)2.44559770
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.40910310
37Delayed epiphyseal ossification (HP:0002663)2.39277657
38Methylmalonic aciduria (HP:0012120)2.39166817
39Increased hepatocellular lipid droplets (HP:0006565)2.36641418
40Hepatic necrosis (HP:0002605)2.33431208
41Duodenal stenosis (HP:0100867)2.31468750
42Small intestinal stenosis (HP:0012848)2.31468750
43Glioma (HP:0009733)2.31273105
44Poor coordination (HP:0002370)2.28736843
45Cerebral edema (HP:0002181)2.26264993
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.25581075
47Congenital, generalized hypertrichosis (HP:0004540)2.25449033
48Abnormality of the labia minora (HP:0012880)2.24066780
49Abnormality of methionine metabolism (HP:0010901)2.23163286
50Abnormality of the renal cortex (HP:0011035)2.20028362
51Azoospermia (HP:0000027)2.18910863
52Abnormality of chromosome stability (HP:0003220)2.18579341
53Aplastic anemia (HP:0001915)2.17299992
54Renal Fanconi syndrome (HP:0001994)2.13295404
55Hypothermia (HP:0002045)2.11591377
56Abnormality of vitamin B metabolism (HP:0004340)2.08973910
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.08593537
58Abnormality of the duodenum (HP:0002246)2.07768540
59Bifid tongue (HP:0010297)2.05642716
60Lipid accumulation in hepatocytes (HP:0006561)2.04592405
61Nephronophthisis (HP:0000090)2.04548065
623-Methylglutaconic aciduria (HP:0003535)2.03726037
63Ependymoma (HP:0002888)2.03121709
64Astrocytoma (HP:0009592)2.02483311
65Abnormality of the astrocytes (HP:0100707)2.02483311
66Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01921588
67Glucose intolerance (HP:0000833)2.01663911
68Abnormality of the vitamin B12 metabolism (HP:0004341)2.00691369
69Genital tract atresia (HP:0001827)1.99908659
70Absent epiphyses (HP:0010577)1.99865883
71Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.99865883
72Hypoplasia of the fovea (HP:0007750)1.99731641
73Aplasia/Hypoplasia of the fovea (HP:0008060)1.99731641
74Colon cancer (HP:0003003)1.99584119
75Neoplasm of the adrenal gland (HP:0100631)1.98598900
76Lactic acidosis (HP:0003128)1.97903686
77Papillary thyroid carcinoma (HP:0002895)1.96253932
78Exercise intolerance (HP:0003546)1.96238095
79Vaginal atresia (HP:0000148)1.95904766
80Abnormality of the pons (HP:0007361)1.95769713
81Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94157176
82Rough bone trabeculation (HP:0100670)1.92712814
83Progressive inability to walk (HP:0002505)1.91749077
84Patellar aplasia (HP:0006443)1.91180733
85Neuroendocrine neoplasm (HP:0100634)1.91049623
86Sloping forehead (HP:0000340)1.90959550
87Abnormal glycosylation (HP:0012345)1.90808976
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90808976
89Abnormal protein N-linked glycosylation (HP:0012347)1.90808976
90Abnormal protein glycosylation (HP:0012346)1.90808976
91Secondary amenorrhea (HP:0000869)1.90626598
92Metaphyseal dysplasia (HP:0100255)1.90371076
93Leukodystrophy (HP:0002415)1.89799058
94Pancreatic fibrosis (HP:0100732)1.89164259
95Aplasia/Hypoplasia of the patella (HP:0006498)1.88897661
96Clubbing of toes (HP:0100760)1.88312161
97Abnormal lung lobation (HP:0002101)1.88270417
98Abnormality of urine glucose concentration (HP:0011016)1.87819323
99Glycosuria (HP:0003076)1.87819323
100Abnormal trabecular bone morphology (HP:0100671)1.87703513
101Abnormality of the proximal phalanges of the hand (HP:0009834)1.85571672
102Abnormality of the epiphysis of the femoral head (HP:0010574)1.85028374
103Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84384681
104Irregular vertebral endplates (HP:0003301)1.83934767
105Short tibia (HP:0005736)1.82949464
106Abnormality of the femoral head (HP:0003368)1.82247559
107Increased serum lactate (HP:0002151)1.81980628
108Abnormality of serum amino acid levels (HP:0003112)1.81938682
109Stenosis of the external auditory canal (HP:0000402)1.81500108
110Small epiphyses (HP:0010585)1.81436560
11111 pairs of ribs (HP:0000878)1.81194330
112Furrowed tongue (HP:0000221)1.81049552
113Fair hair (HP:0002286)1.80990773
114Medulloblastoma (HP:0002885)1.80522914
115Nephroblastoma (Wilms tumor) (HP:0002667)1.79111930
116Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79093025
117Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79093025
118Embryonal renal neoplasm (HP:0011794)1.78670707
119Abnormality of incisor morphology (HP:0011063)1.77954087
120Biliary tract neoplasm (HP:0100574)1.77722989
121Small hand (HP:0200055)1.76881523
122Oligodactyly (hands) (HP:0001180)1.76802597
123Large for gestational age (HP:0001520)1.76347785
124Sclerocornea (HP:0000647)1.75986883
125Generalized aminoaciduria (HP:0002909)1.75971743
126Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.75666332
127Abnormality of femoral epiphyses (HP:0006499)1.75666332
128Chromsome breakage (HP:0040012)1.74920832
129Abnormality of the renal medulla (HP:0100957)1.73300625
130Adrenal hypoplasia (HP:0000835)1.72566365
131Enlarged epiphyses (HP:0010580)1.72432186
132Breast carcinoma (HP:0003002)1.71731676
133Abnormality of the clitoris (HP:0000056)1.70557934
134Reduced antithrombin III activity (HP:0001976)1.69808551
135Pulmonary fibrosis (HP:0002206)1.68976144
136Abnormality of the carotid arteries (HP:0005344)1.68775153
137Microvesicular hepatic steatosis (HP:0001414)1.68619890
138Megaloblastic anemia (HP:0001889)1.68540869
139Abnormal pancreas size (HP:0012094)1.68470745
140Abnormality of the fovea (HP:0000493)1.67923934
141Meckel diverticulum (HP:0002245)1.67629965
142Respiratory failure (HP:0002878)1.67287881
143Steatorrhea (HP:0002570)1.66847113
144Lethargy (HP:0001254)1.66840743
145Optic disc pallor (HP:0000543)1.66598592
146Pancreatic cysts (HP:0001737)1.66092947
147Capillary hemangiomas (HP:0005306)1.64958533
148Tubulointerstitial nephritis (HP:0001970)1.64289141
149Broad foot (HP:0001769)1.63289802
150Mucosal telangiectasiae (HP:0100579)1.62091912
151Exertional dyspnea (HP:0002875)1.61071776
152True hermaphroditism (HP:0010459)1.60832193
153Hypoplasia of the pons (HP:0012110)1.60804242
154Cerebral hypomyelination (HP:0006808)1.57593711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.56962203
2TRIM283.32582321
3AKT32.98295502
4EIF2AK32.90206318
5MST42.64699327
6BUB12.64196212
7SRPK12.62036946
8PBK2.61829344
9PLK42.61248039
10ACVR1B2.26493332
11NUAK12.24963341
12CDC72.17333638
13BMPR22.13958547
14STK162.09721332
15BRSK22.00403131
16CASK1.99065882
17PLK21.97975260
18FRK1.96774849
19CCNB11.94814378
20BMPR1B1.94662328
21ZAK1.93343481
22PDK21.92221755
23STK38L1.83707749
24PLK31.83536904
25MKNK11.79548110
26WNK31.73724358
27VRK11.72320383
28BRAF1.65411094
29BCR1.60229635
30CDK81.50050529
31ERBB31.47728884
32TNIK1.47108226
33WEE11.42573998
34TSSK61.42430744
35MAP4K21.41045157
36MKNK21.38561445
37TTK1.30419215
38VRK21.28187219
39PLK11.28120138
40MST1R1.26761580
41LATS11.15220060
42PASK1.09228893
43EIF2AK21.08888858
44PDK41.08184815
45PDK31.08184815
46NEK61.05125584
47CHEK20.97338948
48DYRK20.97228059
49AURKB0.96488424
50LIMK10.95343046
51MAP2K70.95178575
52BCKDK0.94462797
53TESK10.94386375
54TGFBR10.93684884
55NEK90.91479414
56GRK10.90416162
57TRPM70.89809518
58MYLK0.87988780
59YES10.87397917
60STK30.85238526
61STK390.83308916
62PNCK0.82624275
63OXSR10.82092738
64TLK10.79763785
65PAK30.78352905
66NEK10.77049139
67ERBB40.76320480
68TAF10.73690426
69CSNK1G10.71139569
70MAP3K120.68586819
71AURKA0.68432524
72MAP3K140.67511563
73CSNK1G20.67200724
74CSNK2A10.66266746
75ATM0.66132321
76BRSK10.65984302
77STK40.65347747
78NME10.65119598
79ADRBK20.64150650
80RPS6KA40.62984531
81ATR0.62325052
82PINK10.60070293
83GRK70.58703999
84STK240.57685287
85MELK0.57481539
86FGFR20.54882133
87STK100.54853385
88PIK3CA0.54678202
89ARAF0.54056133
90MET0.53932611
91FGFR10.53550193
92MAP3K40.52825737
93OBSCN0.51209937
94CSNK2A20.49374608
95MARK30.48574463
96CHEK10.48174660
97FER0.47831044
98TXK0.46748934
99SIK30.45658496
100TAOK20.45248026
101CAMKK20.44971825
102MOS0.44851364
103MINK10.44128431
104MAPKAPK30.43748864
105IRAK30.42973373
106PRKCI0.41587700
107CSNK1A1L0.41427162
108IRAK40.41257825
109NEK20.40519780
110TAOK30.39334840
111PHKG10.39140600
112PHKG20.39140600
113RPS6KA50.38631610
114MAP3K30.38095732
115PRKCE0.38022064
116CDK10.37908894
117GRK50.37809113
118CSNK1G30.37692780
119TGFBR20.37498164
120PRKCG0.36469014
121MAPK130.36194444
122WNK40.36168504
123KSR10.35623131
124EPHA20.35438995
125DYRK1A0.34161680
126PIM20.33660466
127CAMK2D0.33453626
128DYRK30.33348538
129CAMK2A0.31400468
130MUSK0.31009618
131CDK30.30772697
132SGK20.28757512
133PIK3CG0.28668181
134ADRBK10.28618310

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.41543725
2Proteasome_Homo sapiens_hsa030504.34899033
3RNA polymerase_Homo sapiens_hsa030203.08543680
4Basal transcription factors_Homo sapiens_hsa030222.89148710
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85951720
6Mismatch repair_Homo sapiens_hsa034302.60508595
7Non-homologous end-joining_Homo sapiens_hsa034502.55806118
8Nucleotide excision repair_Homo sapiens_hsa034202.49669765
9DNA replication_Homo sapiens_hsa030302.46144606
10Oxidative phosphorylation_Homo sapiens_hsa001902.38963085
11RNA transport_Homo sapiens_hsa030132.12931274
12Homologous recombination_Homo sapiens_hsa034402.08672516
13Cell cycle_Homo sapiens_hsa041101.87428571
14Spliceosome_Homo sapiens_hsa030401.85981940
15RNA degradation_Homo sapiens_hsa030181.82793909
16Pyrimidine metabolism_Homo sapiens_hsa002401.81320970
17Fanconi anemia pathway_Homo sapiens_hsa034601.79982554
18Parkinsons disease_Homo sapiens_hsa050121.75178664
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.74388905
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73635600
21Vibrio cholerae infection_Homo sapiens_hsa051101.72478580
22Base excision repair_Homo sapiens_hsa034101.72113704
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70834282
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.67127109
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62723708
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56811525
27Huntingtons disease_Homo sapiens_hsa050161.53581240
28Sulfur metabolism_Homo sapiens_hsa009201.52532601
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34028424
30One carbon pool by folate_Homo sapiens_hsa006701.33341840
31Collecting duct acid secretion_Homo sapiens_hsa049661.31189415
32Butanoate metabolism_Homo sapiens_hsa006501.25996194
33Steroid biosynthesis_Homo sapiens_hsa001001.25125740
34Purine metabolism_Homo sapiens_hsa002301.20999545
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16839046
36Alzheimers disease_Homo sapiens_hsa050101.13868013
37mRNA surveillance pathway_Homo sapiens_hsa030151.12440553
38Folate biosynthesis_Homo sapiens_hsa007901.10623426
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08826578
40Nitrogen metabolism_Homo sapiens_hsa009101.08325058
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01637384
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98663929
43Selenocompound metabolism_Homo sapiens_hsa004500.96294115
44Phagosome_Homo sapiens_hsa041450.94459274
45Rheumatoid arthritis_Homo sapiens_hsa053230.94168423
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.93700228
47Regulation of autophagy_Homo sapiens_hsa041400.92731196
48Epstein-Barr virus infection_Homo sapiens_hsa051690.91903860
49Caffeine metabolism_Homo sapiens_hsa002320.91040335
50Vitamin B6 metabolism_Homo sapiens_hsa007500.88878588
51N-Glycan biosynthesis_Homo sapiens_hsa005100.87021340
52Ribosome_Homo sapiens_hsa030100.86502400
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85183845
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82778352
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81876349
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81724225
57Graft-versus-host disease_Homo sapiens_hsa053320.81075270
58p53 signaling pathway_Homo sapiens_hsa041150.77691412
59Pyruvate metabolism_Homo sapiens_hsa006200.76178622
60Legionellosis_Homo sapiens_hsa051340.75933288
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75873410
62Fatty acid metabolism_Homo sapiens_hsa012120.75216954
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75053075
64Systemic lupus erythematosus_Homo sapiens_hsa053220.73633016
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73369589
66Phototransduction_Homo sapiens_hsa047440.72497782
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.72414945
68Circadian rhythm_Homo sapiens_hsa047100.71067239
69Arachidonic acid metabolism_Homo sapiens_hsa005900.70847177
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68329827
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68171103
72Glutathione metabolism_Homo sapiens_hsa004800.67411590
73Cardiac muscle contraction_Homo sapiens_hsa042600.65552119
74Chemical carcinogenesis_Homo sapiens_hsa052040.65240361
75Tryptophan metabolism_Homo sapiens_hsa003800.64996395
76Type I diabetes mellitus_Homo sapiens_hsa049400.63879652
77Metabolic pathways_Homo sapiens_hsa011000.61060788
78Linoleic acid metabolism_Homo sapiens_hsa005910.60923643
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59500309
80beta-Alanine metabolism_Homo sapiens_hsa004100.58247434
81Oocyte meiosis_Homo sapiens_hsa041140.56325529
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54685557
83Fatty acid degradation_Homo sapiens_hsa000710.53750407
84Antigen processing and presentation_Homo sapiens_hsa046120.52061186
85Nicotine addiction_Homo sapiens_hsa050330.50090252
86Ether lipid metabolism_Homo sapiens_hsa005650.49766194
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46115280
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44629042
89Hedgehog signaling pathway_Homo sapiens_hsa043400.44545286
90TGF-beta signaling pathway_Homo sapiens_hsa043500.44294605
91Vitamin digestion and absorption_Homo sapiens_hsa049770.42820345
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42316474
93Viral carcinogenesis_Homo sapiens_hsa052030.41813079
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41760382
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.41393732
96Autoimmune thyroid disease_Homo sapiens_hsa053200.40397533
97Renin-angiotensin system_Homo sapiens_hsa046140.39832213
98Propanoate metabolism_Homo sapiens_hsa006400.38730051
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37807034
100Taste transduction_Homo sapiens_hsa047420.35154370
101Carbon metabolism_Homo sapiens_hsa012000.34031939
102Sphingolipid metabolism_Homo sapiens_hsa006000.33566221
103Hippo signaling pathway_Homo sapiens_hsa043900.33329764
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33323610
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30503947
106Tyrosine metabolism_Homo sapiens_hsa003500.29453682
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28519053
108Mineral absorption_Homo sapiens_hsa049780.28419035
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.27755153
110Peroxisome_Homo sapiens_hsa041460.27182755
111Herpes simplex infection_Homo sapiens_hsa051680.26875512
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26724522
113Allograft rejection_Homo sapiens_hsa053300.26500164
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25382978
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24067309
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23804232
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22830749
118Fatty acid elongation_Homo sapiens_hsa000620.22324352
119Alcoholism_Homo sapiens_hsa050340.22244630
120Protein digestion and absorption_Homo sapiens_hsa049740.21481065
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18986161
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18344503
123Retinol metabolism_Homo sapiens_hsa008300.16073845
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16019108
125Galactose metabolism_Homo sapiens_hsa000520.15803019
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14372576
127Prostate cancer_Homo sapiens_hsa052150.13173075
128Influenza A_Homo sapiens_hsa051640.11933745
129Arginine and proline metabolism_Homo sapiens_hsa003300.10940994

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