ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	Golgi transport vesicle coating (GO:0048200)	4.75521383
2	COPI coating of Golgi vesicle (GO:0048205)	4.75521383
3	signal peptide processing (GO:0006465)	4.55611497
4	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	4.46626299
5	protein retention in ER lumen (GO:0006621)	4.43601734
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.36905272
7	proline biosynthetic process (GO:0006561)	4.18651013
8	axonemal dynein complex assembly (GO:0070286)	4.17332733
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.09896408
10	ATP synthesis coupled proton transport (GO:0015986)	4.09896408
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.66636030
12	ATP hydrolysis coupled proton transport (GO:0015991)	3.61719377
13	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.61719377
14	protein complex biogenesis (GO:0070271)	3.61144351
15	ribosomal small subunit assembly (GO:0000028)	3.43492051
16	chaperone-mediated protein transport (GO:0072321)	3.39855792
17	keratan sulfate catabolic process (GO:0042340)	3.36285763
18	amyloid precursor protein catabolic process (GO:0042987)	3.35511794
19	viral transcription (GO:0019083)	3.35300475
20	4-hydroxyproline metabolic process (GO:0019471)	3.33535367
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.23678432
22	NADH dehydrogenase complex assembly (GO:0010257)	3.23678432
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.23678432
24	respiratory electron transport chain (GO:0022904)	3.20956176
25	regulation of oxidative phosphorylation (GO:0002082)	3.18402654
26	aldehyde catabolic process (GO:0046185)	3.17805133
27	cullin deneddylation (GO:0010388)	3.17223550
28	electron transport chain (GO:0022900)	3.16785757
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.14948812
30	formation of translation preinitiation complex (GO:0001731)	3.14237513
31	translational termination (GO:0006415)	3.13615954
32	cellular copper ion homeostasis (GO:0006878)	3.09808068
33	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.08015852
34	L-phenylalanine metabolic process (GO:0006558)	3.08015852
35	transferrin transport (GO:0033572)	3.06816950
36	GTP biosynthetic process (GO:0006183)	3.04625669
37	left/right pattern formation (GO:0060972)	3.01553173
38	NADH metabolic process (GO:0006734)	3.01458526
39	protein deneddylation (GO:0000338)	2.99683066
40	proline metabolic process (GO:0006560)	2.98810284
41	protein neddylation (GO:0045116)	2.97911311
42	regulation of cholesterol esterification (GO:0010872)	2.97316134
43	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.95746182
44	translational elongation (GO:0006414)	2.94973499
45	mannosylation (GO:0097502)	2.94704705
46	regulation of cholesterol biosynthetic process (GO:0045540)	2.93160815
47	ferric iron transport (GO:0015682)	2.91602069
48	trivalent inorganic cation transport (GO:0072512)	2.91602069
49	cilium movement (GO:0003341)	2.90360613
50	hydrogen peroxide catabolic process (GO:0042744)	2.86236686
51	mitotic nuclear envelope reassembly (GO:0007084)	2.83956579
52	nuclear envelope reassembly (GO:0031468)	2.83956579
53	peptidyl-proline hydroxylation (GO:0019511)	2.83924541
54	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.78963182
55	viral life cycle (GO:0019058)	2.76226928
56	epithelial cilium movement (GO:0003351)	2.75704352
57	motile cilium assembly (GO:0044458)	2.74626163
58	COPII vesicle coating (GO:0048208)	2.72292049
59	guanosine-containing compound biosynthetic process (GO:1901070)	2.71352424
60	pentose-phosphate shunt (GO:0006098)	2.69754009
61	GDP-mannose metabolic process (GO:0019673)	2.68369398
62	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.68347222
63	NADPH regeneration (GO:0006740)	2.67398589
64	glucose catabolic process (GO:0006007)	2.65635851
65	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.65209897
66	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.65209897
67	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.64838748
68	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.63243052
69	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.62004881
70	regulation of cellular amino acid metabolic process (GO:0006521)	2.61069228
71	dopamine transport (GO:0015872)	2.60900365
72	translational initiation (GO:0006413)	2.60680513
73	glutamine family amino acid biosynthetic process (GO:0009084)	2.60539499
74	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.60043832
75	desmosome organization (GO:0002934)	2.58985231
76	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.55679014
77	hydrogen ion transmembrane transport (GO:1902600)	2.55069205
78	glutathione derivative metabolic process (GO:1901685)	2.54860647
79	glutathione derivative biosynthetic process (GO:1901687)	2.54860647
80	viral protein processing (GO:0019082)	2.54308887
81	cellular protein complex disassembly (GO:0043624)	2.53471456
82	establishment of integrated proviral latency (GO:0075713)	2.52838099
83	primary alcohol catabolic process (GO:0034310)	2.52223606
84	response to misfolded protein (GO:0051788)	2.52143281
85	copper ion homeostasis (GO:0055070)	2.49517529
86	regulation of cellular respiration (GO:0043457)	2.48776953
87	protein targeting to membrane (GO:0006612)	2.48510329
88	glycoside metabolic process (GO:0016137)	2.48326688
89	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.47569478
90	ATP biosynthetic process (GO:0006754)	2.47306164
91	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	2.45858369
92	peptide catabolic process (GO:0043171)	2.45318147
93	adhesion of symbiont to host cell (GO:0044650)	2.44282722
94	virion attachment to host cell (GO:0019062)	2.44282722
95	protein hydroxylation (GO:0018126)	2.43397446
96	intraciliary transport (GO:0042073)	2.43138059
97	ribosomal large subunit biogenesis (GO:0042273)	2.42495932
98	pentose metabolic process (GO:0019321)	2.42452965
99	UTP metabolic process (GO:0046051)	2.42452673
100	basement membrane organization (GO:0071711)	2.42173177
101	cotranslational protein targeting to membrane (GO:0006613)	2.41768780
102	negative regulation of complement activation (GO:0045916)	2.41034527
103	vesicle coating (GO:0006901)	2.40737636
104	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.39503061
105	positive regulation of nuclease activity (GO:0032075)	2.39159352
106	ribosomal small subunit biogenesis (GO:0042274)	2.39125967
107	regulation of cilium movement (GO:0003352)	2.38901490
108	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.37370760
109	succinate metabolic process (GO:0006105)	2.36871053
110	establishment of viral latency (GO:0019043)	2.36627538
111	proton transport (GO:0015992)	2.36357585
112	dermatan sulfate biosynthetic process (GO:0030208)	2.36189714
113	UTP biosynthetic process (GO:0006228)	2.36019726
114	exocrine pancreas development (GO:0031017)	2.35979022
115	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.35661539
116	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.35506940
117	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.35394972
118	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.35394972
119	vitamin transmembrane transport (GO:0035461)	2.34674708
120	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.34547274
121	regulation of mitochondrial translation (GO:0070129)	2.34163638
122	cilium or flagellum-dependent cell motility (GO:0001539)	2.33764065
123	CTP metabolic process (GO:0046036)	2.33621613
124	CTP biosynthetic process (GO:0006241)	2.33621613
125	protein targeting to ER (GO:0045047)	2.33595402
126	plasma lipoprotein particle assembly (GO:0034377)	2.33583190
127	phagosome maturation (GO:0090382)	2.32709502
128	hydrogen transport (GO:0006818)	2.32650908
129	virion assembly (GO:0019068)	2.32052739
130	protein maturation by protein folding (GO:0022417)	2.31553400
131	dermatan sulfate metabolic process (GO:0030205)	2.31382480
132	oxaloacetate metabolic process (GO:0006107)	2.30771781
133	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.30379869
134	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.30379869
135	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.30379869
136	protein localization to endoplasmic reticulum (GO:0070972)	2.30163935
137	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.29527573
138	lung epithelium development (GO:0060428)	2.28963629
139	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.27857953
140	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.27857953
141	extracellular fibril organization (GO:0043206)	2.27782112
142	protein complex disassembly (GO:0043241)	2.27713136
143	fatty acid elongation (GO:0030497)	2.27441191
144	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.27260351
145	adhesion of symbiont to host (GO:0044406)	2.27097274
146	positive regulation of amino acid transport (GO:0051957)	2.26949722
147	inner mitochondrial membrane organization (GO:0007007)	2.23117069
148	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.23096221
149	type B pancreatic cell proliferation (GO:0044342)	2.22397809
150	negative regulation of ligase activity (GO:0051352)	2.21918917
151	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.21918917
152	protein N-linked glycosylation via asparagine (GO:0018279)	2.21764250
153	L-phenylalanine catabolic process (GO:0006559)	2.21437972
154	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.21437972
155	ER overload response (GO:0006983)	2.21201466
156	fucose metabolic process (GO:0006004)	2.20706774
157	regulation of penile erection (GO:0060405)	2.20304857
158	cell redox homeostasis (GO:0045454)	2.20033747
159	respiratory chain complex IV assembly (GO:0008535)	2.18960134
160	proteasome assembly (GO:0043248)	2.18761922
161	cellular iron ion homeostasis (GO:0006879)	2.17316213
162	regulation of metalloenzyme activity (GO:0048552)	2.17256748
163	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.16442685
164	peptidyl-asparagine modification (GO:0018196)	2.15993423
165	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.15791284

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.54098370
2	TRIM28_21343339_ChIP-Seq_HEK293_Human	3.24964430
3	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.84081858
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.60135151
5	ZNF263_19887448_ChIP-Seq_K562_Human	2.59666706
6	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.43359748
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.40148430
8	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.32094608
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.30106438
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.29035743
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.27300371
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.23881484
13	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.22156546
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.20274590
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.18743044
16	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.18006692
17	XRN2_22483619_ChIP-Seq_HELA_Human	2.14707148
18	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.06473865
19	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.02469515
20	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.00078912
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.98656026
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.95204914
23	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.89856940
24	DCP1A_22483619_ChIP-Seq_HELA_Human	1.88104076
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.85090133
26	* GABP_19822575_ChIP-Seq_HepG2_Human	1.83573147
27	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.82234807
28	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.78001877
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.77678310
30	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.77090439
31	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.74191375
32	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.73923062
33	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.73690546
34	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.73040462
35	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.71346938
36	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.69452553
37	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.68211311
38	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.68173241
39	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.68042330
40	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.67023030
41	RACK7_27058665_Chip-Seq_MCF-7_Human	1.66194653
42	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.65363353
43	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.65361732
44	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.60934287
45	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.60246104
46	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.59409473
47	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.55954470
48	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.53928789
49	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.52949176
50	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.50576000
51	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.49465745
52	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.49010387
53	TTF2_22483619_ChIP-Seq_HELA_Human	1.45502687
54	KDM5A_27292631_Chip-Seq_BREAST_Human	1.44444734
55	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.39702880
56	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.39177906
57	CLOCK_20551151_ChIP-Seq_293T_Human	1.37507750
58	LXR_22292898_ChIP-Seq_THP-1_Human	1.37194718
59	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.36782744
60	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.36210018
61	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.35682231
62	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.34889067
63	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.34777319
64	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.34673595
65	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.34577552
66	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.33781764
67	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.33552962
68	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.33112471
69	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.32809176
70	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.32374268
71	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31764909
72	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.31371069
73	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.30752928
74	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.30542073
75	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.29081767
76	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.28385632
77	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.27760524
78	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.27760524
79	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.25606790
80	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.25016938
81	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.24546914
82	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.24127231
83	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.23241009
84	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.23178056
85	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.22201124
86	* MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.21980785
87	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.21774238
88	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.21313748
89	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.21120976
90	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.20424082
91	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	1.20197403
92	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.19614731
93	ATF3_27146783_Chip-Seq_COLON_Human	1.19133217
94	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.17849316
95	* KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.17798869
96	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.17355029
97	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.16452337
98	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.15988822
99	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.14276268
100	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.13573951
101	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.13154264
102	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.13094299
103	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.11616553
104	TFEB_21752829_ChIP-Seq_HELA_Human	1.11004911
105	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.10295773
106	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.09481166
107	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09232382
108	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.09113285
109	* CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.08989423
110	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.08986803
111	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05863554
112	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.04884148
113	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.03809895
114	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.03622698
115	GBX2_23144817_ChIP-Seq_PC3_Human	1.03356814
116	P68_20966046_ChIP-Seq_HELA_Human	1.02981119
117	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02832039
118	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.01470949
119	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.00857075
120	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.00300040
121	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.00300040
122	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.00039963
123	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.98682993
124	AR_21909140_ChIP-Seq_LNCAP_Human	0.98080710
125	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.97303377
126	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96895979
127	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.96510434
128	* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.95960983
129	SOX2_20726797_ChIP-Seq_SW620_Human	0.95510316
130	CTCF_20526341_ChIP-Seq_ESCs_Human	0.95271988
131	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.94944742
132	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.94668866
133	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.94073949
134	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.92719872
135	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.92658816
136	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.92061358
137	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.91346251
138	* SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.91271663
139	AR_20517297_ChIP-Seq_VCAP_Human	0.85995221
140	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.84385734
141	* PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.81266060
142	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.81252760
143	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.80553119
144	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.80317129
145	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.79912228
146	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.78870386
147	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.77356606
148	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.76816539
149	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.76218236
150	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.75771583
151	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.75766837
152	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.74805883
153	EOMES_21245162_ChIP-Seq_HESCs_Human	0.73092720
154	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.73031335
155	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.72094066

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008438_abnormal_cutaneous_collagen	5.11573805
2	MP0005503_abnormal_tendon_morphology	4.79899886
3	MP0009840_abnormal_foam_cell	3.36017882
4	MP0003122_maternal_imprinting	3.33629995
5	MP0005275_abnormal_skin_tensile	3.10867373
6	MP0006054_spinal_hemorrhage	3.08161644
7	MP0010386_abnormal_urinary_bladder	2.54888506
8	MP0005257_abnormal_intraocular_pressure	2.52828342
9	MP0000566_synostosis	2.47552743
10	MP0004272_abnormal_basement_membrane	2.32975453
11	MP0003191_abnormal_cellular_cholesterol	2.15585583
12	MP0005058_abnormal_lysosome_morphology	2.07832153
13	MP0001958_emphysema	2.03097770
14	MP0000372_irregular_coat_pigmentation	1.96127115
15	MP0002876_abnormal_thyroid_physiology	1.83690232
16	MP0003279_aneurysm	1.83094224
17	MP0008875_abnormal_xenobiotic_pharmacok	1.82529942
18	MP0000013_abnormal_adipose_tissue	1.81212084
19	MP0001529_abnormal_vocalization	1.79085318
20	MP0009384_cardiac_valve_regurgitation	1.73474318
21	MP0010234_abnormal_vibrissa_follicle	1.73247599
22	MP0001664_abnormal_digestion	1.70770763
23	MP0003136_yellow_coat_color	1.68760815
24	MP0002638_abnormal_pupillary_reflex	1.63453512
25	MP0005360_urolithiasis	1.62574076
26	MP0000538_abnormal_urinary_bladder	1.59466657
27	MP0005508_abnormal_skeleton_morphology	1.58802967
28	MP0005646_abnormal_pituitary_gland	1.57672711
29	MP0005220_abnormal_exocrine_pancreas	1.53233830
30	MP0002295_abnormal_pulmonary_circulatio	1.51863569
31	MP0001849_ear_inflammation	1.51827973
32	MP0002132_abnormal_respiratory_system	1.49318685
33	MP0005645_abnormal_hypothalamus_physiol	1.48769768
34	MP0003942_abnormal_urinary_system	1.48317439
35	MP0002653_abnormal_ependyma_morphology	1.46874028
36	MP0009379_abnormal_foot_pigmentation	1.45959429
37	MP0004264_abnormal_extraembryonic_tissu	1.43556124
38	MP0000681_abnormal_thyroid_gland	1.43452869
39	MP0002909_abnormal_adrenal_gland	1.42417142
40	MP0002938_white_spotting	1.42191040
41	MP0001756_abnormal_urination	1.41466453
42	MP0001542_abnormal_bone_strength	1.40292904
43	MP0006276_abnormal_autonomic_nervous	1.40126044
44	MP0003195_calcinosis	1.38853795
45	MP0001905_abnormal_dopamine_level	1.38754479
46	MP0002098_abnormal_vibrissa_morphology	1.35874193
47	MP0003183_abnormal_peptide_metabolism	1.33912450
48	MP0009780_abnormal_chondrocyte_physiolo	1.33704780
49	MP0003329_amyloid_beta_deposits	1.31830213
50	MP0001346_abnormal_lacrimal_gland	1.29222885
51	MP0005084_abnormal_gallbladder_morpholo	1.27178984
52	MP0000537_abnormal_urethra_morphology	1.27051954
53	MP0000049_abnormal_middle_ear	1.26143757
54	MP0008260_abnormal_autophagy	1.25595103
55	MP0002090_abnormal_vision	1.24978722
56	MP0003315_abnormal_perineum_morphology	1.24862187
57	MP0005636_abnormal_mineral_homeostasis	1.22765577
58	MP0002089_abnormal_postnatal_growth/wei	1.22685858
59	MP0005332_abnormal_amino_acid	1.21026158
60	MP0002108_abnormal_muscle_morphology	1.20327349
61	MP0008007_abnormal_cellular_replicative	1.19011084
62	MP0002736_abnormal_nociception_after	1.15629998
63	MP0004043_abnormal_pH_regulation	1.15244182
64	MP0003566_abnormal_cell_adhesion	1.14698657
65	MP0004858_abnormal_nervous_system	1.13970905
66	MP0001666_abnormal_nutrient_absorption	1.11072645
67	MP0000678_abnormal_parathyroid_gland	1.07600156
68	MP0010368_abnormal_lymphatic_system	1.07471654
69	MP0008004_abnormal_stomach_pH	1.07035880
70	MP0005501_abnormal_skin_physiology	1.06826029
71	MP0000467_abnormal_esophagus_morphology	1.06717608
72	MP0003941_abnormal_skin_development	1.06351611
73	MP0005451_abnormal_body_composition	1.06112928
74	MP0005595_abnormal_vascular_smooth	1.05338467
75	MP0000534_abnormal_ureter_morphology	1.04529555
76	MP0008932_abnormal_embryonic_tissue	1.04477993
77	MP0000358_abnormal_cell_content/	1.04068429
78	MP0005377_hearing/vestibular/ear_phenot	1.03010395
79	MP0003878_abnormal_ear_physiology	1.03010395
80	MP0003638_abnormal_response/metabolism_	1.02681134
81	MP0001299_abnormal_eye_distance/	1.00305670
82	MP0002796_impaired_skin_barrier	0.98909072
83	MP0005171_absent_coat_pigmentation	0.98230185
84	MP0001243_abnormal_dermal_layer	0.97902565
85	MP0005367_renal/urinary_system_phenotyp	0.97718293
86	MP0000516_abnormal_urinary_system	0.97718293
87	MP0005083_abnormal_biliary_tract	0.97202655
88	MP0003959_abnormal_lean_body	0.96798320
89	MP0005379_endocrine/exocrine_gland_phen	0.96792217
90	MP0005023_abnormal_wound_healing	0.96576460
91	MP0003172_abnormal_lysosome_physiology	0.96528309
92	MP0001270_distended_abdomen	0.96093149
93	MP0005410_abnormal_fertilization	0.95698493
94	MP0005408_hypopigmentation	0.95417034
95	MP0003705_abnormal_hypodermis_morpholog	0.95189914
96	MP0009697_abnormal_copulation	0.94567824
97	MP0002282_abnormal_trachea_morphology	0.93880798
98	MP0004134_abnormal_chest_morphology	0.93879093
99	MP0000762_abnormal_tongue_morphology	0.93209995
100	MP0000631_abnormal_neuroendocrine_gland	0.92892607
101	MP0000462_abnormal_digestive_system	0.91316311
102	MP0005365_abnormal_bile_salt	0.91079186
103	MP0001881_abnormal_mammary_gland	0.90387062
104	MP0004142_abnormal_muscle_tone	0.89946596
105	MP0002877_abnormal_melanocyte_morpholog	0.89885968
106	MP0003011_delayed_dark_adaptation	0.89653648
107	MP0009643_abnormal_urine_homeostasis	0.89125040
108	MP0005623_abnormal_meninges_morphology	0.88866467
109	MP0005197_abnormal_uvea_morphology	0.88065259
110	MP0003186_abnormal_redox_activity	0.87074617
111	MP0000230_abnormal_systemic_arterial	0.87002765
112	MP0004957_abnormal_blastocyst_morpholog	0.86755296
113	MP0002233_abnormal_nose_morphology	0.86276867
114	MP0003786_premature_aging	0.84900214
115	MP0002697_abnormal_eye_size	0.84809638
116	MP0009053_abnormal_anal_canal	0.84650271
117	MP0000163_abnormal_cartilage_morphology	0.83290754
118	MP0004133_heterotaxia	0.82821292
119	MP0002822_catalepsy	0.82796880
120	MP0003385_abnormal_body_wall	0.82529073
121	MP0003634_abnormal_glial_cell	0.80994073
122	MP0004883_abnormal_blood_vessel	0.80070931
123	MP0002064_seizures	0.79947427
124	MP0001177_atelectasis	0.79713995
125	MP0000639_abnormal_adrenal_gland	0.79444816
126	MP0002092_abnormal_eye_morphology	0.78931955
127	MP0005390_skeleton_phenotype	0.78917395
128	MP0005164_abnormal_response_to	0.78278138
129	MP0003879_abnormal_hair_cell	0.77945747
130	MP0001216_abnormal_epidermal_layer	0.77716411
131	MP0002896_abnormal_bone_mineralization	0.77108410
132	MP0001764_abnormal_homeostasis	0.76723965
133	MP0004019_abnormal_vitamin_homeostasis	0.76632547
134	MP0002249_abnormal_larynx_morphology	0.76436860
135	MP0001502_abnormal_circadian_rhythm	0.76188388
136	MP0001879_abnormal_lymphatic_vessel	0.75358225
137	MP0002060_abnormal_skin_morphology	0.75011889
138	MP0000377_abnormal_hair_follicle	0.74521041
139	MP0010678_abnormal_skin_adnexa	0.74208055
140	MP0010771_integument_phenotype	0.73860270
141	MP0003693_abnormal_embryo_hatching	0.72840145
142	MP0002572_abnormal_emotion/affect_behav	0.72693099
143	MP0001944_abnormal_pancreas_morphology	0.72301693
144	MP0003718_maternal_effect	0.71851397
145	MP0002933_joint_inflammation	0.71842083
146	MP0002139_abnormal_hepatobiliary_system	0.71302605
147	MP0003806_abnormal_nucleotide_metabolis	0.71286021
148	MP0005248_abnormal_Harderian_gland	0.71124695
149	MP0005165_increased_susceptibility_to	0.70749263
150	MP0002734_abnormal_mechanical_nocicepti	0.70507821
151	MP0002075_abnormal_coat/hair_pigmentati	0.70216078
152	MP0001765_abnormal_ion_homeostasis	0.70075226
153	MP0004782_abnormal_surfactant_physiolog	0.69695934
154	MP0000371_diluted_coat_color	0.69448361
155	MP0003283_abnormal_digestive_organ	0.69302016
156	MP0006036_abnormal_mitochondrial_physio	0.68680161
157	MP0003115_abnormal_respiratory_system	0.68678768
158	MP0002932_abnormal_joint_morphology	0.68652051
159	MP0010030_abnormal_orbit_morphology	0.68537027
160	MP0000647_abnormal_sebaceous_gland	0.68487546
161	MP0005551_abnormal_eye_electrophysiolog	0.68389906
162	MP0000604_amyloidosis	0.67530281
163	MP0008789_abnormal_olfactory_epithelium	0.66103629

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.79195004
2	Acute necrotizing encephalopathy (HP:0006965)	4.25608704
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.09688064
4	Protrusio acetabuli (HP:0003179)	3.77527122
5	Abnormal respiratory motile cilium physiology (HP:0012261)	3.75949145
6	Acute encephalopathy (HP:0006846)	3.71782812
7	Short nail (HP:0001799)	3.68312605
8	Abnormal respiratory epithelium morphology (HP:0012253)	3.65336533
9	Abnormal respiratory motile cilium morphology (HP:0005938)	3.65336533
10	Mitochondrial inheritance (HP:0001427)	3.65237645
11	Rhinitis (HP:0012384)	3.63401699
12	Vertebral compression fractures (HP:0002953)	3.53036129
13	Abnormal ciliary motility (HP:0012262)	3.42837566
14	Abnormality of dentin (HP:0010299)	3.42106665
15	Progressive macrocephaly (HP:0004481)	3.37346237
16	Hand muscle atrophy (HP:0009130)	3.22775692
17	Vacuolated lymphocytes (HP:0001922)	3.21536576
18	Renal Fanconi syndrome (HP:0001994)	3.20069717
19	Hepatocellular necrosis (HP:0001404)	3.16816636
20	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.13229325
21	Absent/shortened dynein arms (HP:0200106)	3.13229325
22	Increased CSF lactate (HP:0002490)	2.99446947
23	Hypothermia (HP:0002045)	2.86199487
24	Hepatic necrosis (HP:0002605)	2.85033274
25	Distal upper limb amyotrophy (HP:0007149)	2.81380351
26	Upper limb amyotrophy (HP:0009129)	2.81380351
27	Occipital encephalocele (HP:0002085)	2.78301575
28	Dysostosis multiplex (HP:0000943)	2.75413599
29	Cervical subluxation (HP:0003308)	2.70400016
30	Abnormality of renal resorption (HP:0011038)	2.57388528
31	Polyphagia (HP:0002591)	2.56777410
32	Beaking of vertebral bodies (HP:0004568)	2.54884876
33	Vascular tortuosity (HP:0004948)	2.51682528
34	Abnormality of the distal phalanges of the toes (HP:0010182)	2.44933461
35	Broad metatarsal (HP:0001783)	2.44491030
36	Broad distal phalanx of finger (HP:0009836)	2.44398847
37	Premature rupture of membranes (HP:0001788)	2.42358086
38	Neuroendocrine neoplasm (HP:0100634)	2.37954804
39	Biconcave vertebral bodies (HP:0004586)	2.37628404
40	Nephrogenic diabetes insipidus (HP:0009806)	2.33378236
41	Increased hepatocellular lipid droplets (HP:0006565)	2.32744837
42	Arterial tortuosity (HP:0005116)	2.32107576
43	Pheochromocytoma (HP:0002666)	2.29183956
44	Chronic bronchitis (HP:0004469)	2.26689105
45	Lipid accumulation in hepatocytes (HP:0006561)	2.26473734
46	Male infertility (HP:0003251)	2.25157680
47	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.24042092
48	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.20168868
49	Degeneration of anterior horn cells (HP:0002398)	2.19256718
50	Abnormality of the anterior horn cell (HP:0006802)	2.19256718
51	Hypoplasia of the uterus (HP:0000013)	2.18455182
52	Respiratory failure (HP:0002878)	2.16359016
53	Flattened epiphyses (HP:0003071)	2.14815707
54	Medial flaring of the eyebrow (HP:0010747)	2.14200445
55	Nasal polyposis (HP:0100582)	2.13989682
56	Conjugated hyperbilirubinemia (HP:0002908)	2.11905361
57	Abnormality of glycolipid metabolism (HP:0010969)	2.09202557
58	Abnormality of liposaccharide metabolism (HP:0010968)	2.09202557
59	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.09202557
60	Cerebral edema (HP:0002181)	2.08989251
61	Tubulointerstitial nephritis (HP:0001970)	2.08920183
62	Atelectasis (HP:0100750)	2.07846974
63	Poor suck (HP:0002033)	2.07101299
64	Increased intramyocellular lipid droplets (HP:0012240)	2.06986912
65	Type I transferrin isoform profile (HP:0003642)	2.06843224
66	Prolonged neonatal jaundice (HP:0006579)	2.06100679
67	Glycosuria (HP:0003076)	2.06090094
68	Abnormality of urine glucose concentration (HP:0011016)	2.06090094
69	Abnormal number of erythroid precursors (HP:0012131)	2.05902903
70	Increased cerebral lipofuscin (HP:0011813)	2.05270671
71	Abnormal protein N-linked glycosylation (HP:0012347)	2.04343331
72	Abnormal protein glycosylation (HP:0012346)	2.04343331
73	Abnormal glycosylation (HP:0012345)	2.04343331
74	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.04343331
75	Trismus (HP:0000211)	2.02557886
76	Exercise intolerance (HP:0003546)	2.02543771
77	Loss of speech (HP:0002371)	2.02238584
78	Absent epiphyses (HP:0010577)	2.00450555
79	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.00450555
80	Urinary glycosaminoglycan excretion (HP:0003541)	2.00361753
81	Mucopolysacchariduria (HP:0008155)	2.00361753
82	Lactic acidosis (HP:0003128)	2.00018242
83	Leukodystrophy (HP:0002415)	1.97550596
84	Narrow nasal bridge (HP:0000446)	1.97440872
85	Deep venous thrombosis (HP:0002625)	1.97035711
86	Abnormality of cells of the erythroid lineage (HP:0012130)	1.96153310
87	Congenital primary aphakia (HP:0007707)	1.95140602
88	Hypokalemic alkalosis (HP:0001949)	1.94794100
89	Aplasia/hypoplasia of the uterus (HP:0008684)	1.94620440
90	Renal tubular dysfunction (HP:0000124)	1.94404862
91	J-shaped sella turcica (HP:0002680)	1.93578624
92	Gait imbalance (HP:0002141)	1.93233499
93	Hyperactive renin-angiotensin system (HP:0000841)	1.93138996
94	Testicular atrophy (HP:0000029)	1.92477268
95	Bell-shaped thorax (HP:0001591)	1.92177115
96	Nuclear cataract (HP:0100018)	1.91981095
97	Soft skin (HP:0000977)	1.91130990
98	Epiphyseal stippling (HP:0010655)	1.90732407
99	Renal salt wasting (HP:0000127)	1.90289067
100	Methylmalonic aciduria (HP:0012120)	1.89417887
101	Increased muscle lipid content (HP:0009058)	1.88592882
102	True hermaphroditism (HP:0010459)	1.88009998
103	Abnormal delivery (HP:0001787)	1.87411748
104	Rough bone trabeculation (HP:0100670)	1.85163500
105	Hypoventilation (HP:0002791)	1.84592018
106	Opisthotonus (HP:0002179)	1.84236073
107	Abnormality of the nasal mucosa (HP:0000433)	1.83483516
108	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.83291016
109	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.83047983
110	Hyperphosphaturia (HP:0003109)	1.82906740
111	Hyperaldosteronism (HP:0000859)	1.81492741
112	Increased serum pyruvate (HP:0003542)	1.81181919
113	Abnormality of glycolysis (HP:0004366)	1.81181919
114	Labial hypoplasia (HP:0000066)	1.80728251
115	Abnormality of polysaccharide metabolism (HP:0011012)	1.80102664
116	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.80102664
117	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.80102664
118	Abnormality of carpal bone ossification (HP:0006257)	1.79925735
119	Glucose intolerance (HP:0000833)	1.78930142
120	Oligomenorrhea (HP:0000876)	1.78734152
121	Cholecystitis (HP:0001082)	1.77404678
122	Abnormal gallbladder physiology (HP:0012438)	1.77404678
123	Optic disc pallor (HP:0000543)	1.76726298
124	Neoplasm of head and neck (HP:0012288)	1.76307390
125	Esophageal neoplasm (HP:0100751)	1.76307390
126	Neurofibrillary tangles (HP:0002185)	1.75894881
127	Progressive neurologic deterioration (HP:0002344)	1.75769308
128	Back pain (HP:0003418)	1.75234520
129	Systemic lupus erythematosus (HP:0002725)	1.74948712
130	Decreased circulating renin level (HP:0003351)	1.74471100
131	Congenital glaucoma (HP:0001087)	1.73841717
132	Reticulocytopenia (HP:0001896)	1.73276996
133	Pancreatic fibrosis (HP:0100732)	1.72743459
134	Primary adrenal insufficiency (HP:0008207)	1.71193184
135	CNS demyelination (HP:0007305)	1.70923115
136	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.70748561
137	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.70748561
138	Bronchiectasis (HP:0002110)	1.70730339
139	Vertebral hypoplasia (HP:0008417)	1.70727240
140	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	1.70727240
141	3-Methylglutaconic aciduria (HP:0003535)	1.69962325
142	Sparse eyelashes (HP:0000653)	1.68621392
143	Abnormality of the umbilical cord (HP:0010881)	1.68593124
144	Hypokinesia (HP:0002375)	1.68078126
145	Pterygium (HP:0001059)	1.67880661
146	Abnormality of the acetabulum (HP:0003170)	1.67104125
147	Cerebral palsy (HP:0100021)	1.66977106
148	Spastic paraparesis (HP:0002313)	1.66734570
149	Joint stiffness (HP:0001387)	1.66314852
150	Craniofacial dystonia (HP:0012179)	1.66165070
151	Gout (HP:0001997)	1.66018881
152	Facial cleft (HP:0002006)	1.65564231
153	Ketoacidosis (HP:0001993)	1.64755584
154	Wormian bones (HP:0002645)	1.64551720
155	Hypoplastic female external genitalia (HP:0012815)	1.63719045
156	Abnormal hair whorl (HP:0010721)	1.63085909
157	Follicular hyperkeratosis (HP:0007502)	1.60289599
158	Down-sloping shoulders (HP:0200021)	1.59934562
159	Abnormalities of placenta or umbilical cord (HP:0001194)	1.59215250
160	Abnormality of the Achilles tendon (HP:0005109)	1.58422749
161	Vascular calcification (HP:0004934)	1.57704057
162	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.57274889
163	Spinal cord compression (HP:0002176)	1.56757655
164	Microglossia (HP:0000171)	1.56133455
165	Infertility (HP:0000789)	1.51698987
166	Abnormal trabecular bone morphology (HP:0100671)	1.51338837

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.53362705
2	MAP3K12	3.36160298
3	MYLK	3.20695934
4	CASK	2.94440629
5	ERN1	2.89693872
6	BCKDK	2.86370105
7	PIM2	2.85103601
8	ARAF	2.69945992
9	STK16	2.61429745
10	TRIB3	2.57421796
11	TESK2	2.54537179
12	IRAK3	2.17922254
13	PBK	2.11673169
14	TESK1	1.97284582
15	EPHB2	1.95608251
16	MAPK15	1.93773206
17	WNK3	1.90088052
18	NME1	1.87974374
19	TSSK6	1.86432122
20	AKT3	1.85413367
21	LMTK2	1.80965894
22	BRAF	1.79967650
23	CDK19	1.75755776
24	SMG1	1.75685891
25	WNK4	1.71689653
26	ICK	1.50976580
27	BUB1	1.45389580
28	SIK3	1.41961879
29	PTK2	1.39986268
30	MAPKAPK3	1.39846903
31	BMPR1B	1.38138631
32	PLK2	1.34890714
33	PIK3CG	1.34369146
34	MST1R	1.33327197
35	LIMK1	1.33021384
36	EIF2AK1	1.30088531
37	TGFBR2	1.28232060
38	OXSR1	1.22220509
39	NME2	1.20697175
40	PKN2	1.19453984
41	CDK8	1.19057612
42	BRSK1	1.18445746
43	SCYL2	1.17561137
44	MAP2K7	1.15796649
45	PAK4	1.15791452
46	TGFBR1	1.14116833
47	MUSK	1.12106099
48	EPHA3	1.11306113
49	ADRBK2	1.10323107
50	CDK7	1.08647045
51	MAP3K3	1.08063988
52	EPHA2	1.06902902
53	DDR2	1.05784405
54	ABL2	1.05073533
55	ILK	1.02190230
56	FER	1.00536363
57	SIK1	0.99623018
58	INSRR	0.99573650
59	PRKD3	0.98477950
60	EEF2K	0.96358762
61	ERBB3	0.95914939
62	NEK1	0.94273530
63	RPS6KB2	0.94031572
64	GRK7	0.93876118
65	TIE1	0.93792667
66	UHMK1	0.93524819
67	KIT	0.93190961
68	NTRK2	0.92663437
69	EPHB1	0.92655950
70	DAPK3	0.91863625
71	MAP2K2	0.91739371
72	DAPK1	0.89344140
73	PDGFRA	0.85496588
74	FGFR4	0.84388425
75	PRKCE	0.84250716
76	NTRK1	0.83388571
77	PTK6	0.82897549
78	ADRBK1	0.82428182
79	MAPK13	0.81530504
80	EIF2AK3	0.81515868
81	MAPKAPK5	0.81044038
82	DYRK2	0.78948012
83	BCR	0.78459878
84	TTK	0.77964082
85	SGK223	0.77270417
86	SGK494	0.77270417
87	FRK	0.76251063
88	PRKCI	0.73750801
89	MAP3K2	0.72960820
90	WEE1	0.70164791
91	CSNK1A1L	0.70052852
92	CAMK2G	0.64108234
93	TNK2	0.63385032
94	AURKA	0.62974983
95	IRAK1	0.62224481
96	CSNK1G1	0.61823727
97	MARK1	0.60348768
98	BRSK2	0.60275352
99	PDK2	0.59928431
100	SRPK1	0.58668158
101	FLT3	0.58297934
102	LRRK2	0.58051778
103	CAMKK2	0.57035293
104	PRKCG	0.57020694
105	DAPK2	0.55392863
106	BMX	0.55335453
107	PASK	0.54531385
108	CCNB1	0.54300370
109	MST4	0.53951628
110	STK39	0.51831947
111	PRKG2	0.51324721
112	PDK3	0.50662823
113	PDK4	0.50662823
114	TRIM28	0.50352878
115	MAP2K1	0.49212692
116	IRAK2	0.48680326
117	MET	0.48184906
118	PAK2	0.46903939
119	ROCK2	0.46570541
120	AURKB	0.46492772
121	ERBB4	0.45353528
122	STK38	0.45289486
123	CSNK1G3	0.44788127
124	NTRK3	0.44747396
125	PRPF4B	0.43945683
126	VRK1	0.43237003
127	CAMK2B	0.42157517
128	RPS6KA2	0.41767085
129	MAP3K6	0.41468027
130	AKT2	0.41339893
131	MAP2K6	0.40949764
132	PLK1	0.39104661
133	CDK18	0.38657132
134	CDK14	0.37693326
135	PRKD2	0.37667150
136	ROCK1	0.37076421
137	CSNK1G2	0.36930451
138	TNIK	0.36735468
139	CHEK2	0.36585983
140	MINK1	0.35806273
141	DYRK1B	0.34544790
142	CDK9	0.34331878
143	CSNK2A1	0.32500382
144	GSK3A	0.32347491
145	NEK2	0.32227654
146	CSNK2A2	0.31725854
147	MTOR	0.31323778
148	MAP4K2	0.31291675
149	TAOK2	0.30335021
150	PAK1	0.30331075
151	TBK1	0.26459562
152	MAPKAPK2	0.23790211

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	4.47216048
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.88129087
3	Parkinsons disease_Homo sapiens_hsa05012	3.05030682
4	Proteasome_Homo sapiens_hsa03050	2.91836936
5	Vibrio cholerae infection_Homo sapiens_hsa05110	2.82986984
6	Collecting duct acid secretion_Homo sapiens_hsa04966	2.73186759
7	Alzheimers disease_Homo sapiens_hsa05010	2.26306973
8	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.22643786
9	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.14083544
10	Sulfur metabolism_Homo sapiens_hsa00920	2.06877976
11	Huntingtons disease_Homo sapiens_hsa05016	2.05270265
12	Other glycan degradation_Homo sapiens_hsa00511	2.02731198
13	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.01161277
14	Fatty acid elongation_Homo sapiens_hsa00062	1.96836435
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.78497795
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.77279205
17	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.74030486
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.71356838
19	Lysosome_Homo sapiens_hsa04142	1.64525584
20	Ribosome_Homo sapiens_hsa03010	1.63210326
21	Pyruvate metabolism_Homo sapiens_hsa00620	1.59393969
22	Base excision repair_Homo sapiens_hsa03410	1.50999302
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.49555062
24	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.49394544
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.41055056
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.37106442
27	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.33583780
28	Phagosome_Homo sapiens_hsa04145	1.30564498
29	Butanoate metabolism_Homo sapiens_hsa00650	1.28794036
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.24885749
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.23545751
32	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.22372313
33	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.20000913
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19506581
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.17968904
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.17711105
37	Propanoate metabolism_Homo sapiens_hsa00640	1.14610078
38	DNA replication_Homo sapiens_hsa03030	1.13405065
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.10698255
40	Sulfur relay system_Homo sapiens_hsa04122	1.08835046
41	Fatty acid metabolism_Homo sapiens_hsa01212	1.07416661
42	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.06998904
43	Nucleotide excision repair_Homo sapiens_hsa03420	1.05438906
44	Rheumatoid arthritis_Homo sapiens_hsa05323	1.05432247
45	Glutathione metabolism_Homo sapiens_hsa00480	1.05416534
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.02134767
47	Histidine metabolism_Homo sapiens_hsa00340	1.01013363
48	Mismatch repair_Homo sapiens_hsa03430	1.00808635
49	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.99221063
50	Galactose metabolism_Homo sapiens_hsa00052	0.96860564
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.95202004
52	Peroxisome_Homo sapiens_hsa04146	0.94563651
53	Fatty acid degradation_Homo sapiens_hsa00071	0.93645815
54	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.93544872
55	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.92282499
56	Complement and coagulation cascades_Homo sapiens_hsa04610	0.92212242
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.91419570
58	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.91381317
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90919651
60	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.88427299
61	Protein digestion and absorption_Homo sapiens_hsa04974	0.88205838
62	Regulation of autophagy_Homo sapiens_hsa04140	0.86473471
63	Carbon metabolism_Homo sapiens_hsa01200	0.86095941
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85066798
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84300759
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.83995816
67	Metabolic pathways_Homo sapiens_hsa01100	0.83943188
68	Folate biosynthesis_Homo sapiens_hsa00790	0.83766268
69	Tyrosine metabolism_Homo sapiens_hsa00350	0.82410786
70	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82103985
71	Renin-angiotensin system_Homo sapiens_hsa04614	0.78774586
72	Phenylalanine metabolism_Homo sapiens_hsa00360	0.78488282
73	Arginine biosynthesis_Homo sapiens_hsa00220	0.78424939
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.75493638
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75127126
76	GABAergic synapse_Homo sapiens_hsa04727	0.73468066
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.71858312
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.71281444
79	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.67380661
80	Sphingolipid metabolism_Homo sapiens_hsa00600	0.66923266
81	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.66109107
82	Spliceosome_Homo sapiens_hsa03040	0.64613106
83	Cocaine addiction_Homo sapiens_hsa05030	0.62802179
84	Nicotine addiction_Homo sapiens_hsa05033	0.62799998
85	Prion diseases_Homo sapiens_hsa05020	0.60554956
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60524088
87	RNA transport_Homo sapiens_hsa03013	0.60433324
88	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.60040441
89	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.59202391
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59067510
91	Purine metabolism_Homo sapiens_hsa00230	0.58480652
92	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.56113065
93	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.53536638
94	Retinol metabolism_Homo sapiens_hsa00830	0.50263766
95	Insulin secretion_Homo sapiens_hsa04911	0.50181586
96	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.49948756
97	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.49933679
98	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.47133094
99	ECM-receptor interaction_Homo sapiens_hsa04512	0.46813701
100	Basal cell carcinoma_Homo sapiens_hsa05217	0.45994737
101	Tryptophan metabolism_Homo sapiens_hsa00380	0.44102581
102	Pentose phosphate pathway_Homo sapiens_hsa00030	0.44089838
103	Bladder cancer_Homo sapiens_hsa05219	0.43012974
104	PPAR signaling pathway_Homo sapiens_hsa03320	0.42755515
105	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40949382
106	RNA polymerase_Homo sapiens_hsa03020	0.39948314
107	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39437764
108	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.39365354
109	Non-homologous end-joining_Homo sapiens_hsa03450	0.37813801
110	Mineral absorption_Homo sapiens_hsa04978	0.37391120
111	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36192689
112	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.35110389
113	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.34753378
114	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33640518
115	Homologous recombination_Homo sapiens_hsa03440	0.33373467
116	Tight junction_Homo sapiens_hsa04530	0.33026639
117	Serotonergic synapse_Homo sapiens_hsa04726	0.31895614
118	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.31570565
119	Pancreatic secretion_Homo sapiens_hsa04972	0.31513833
120	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.31356891
121	Taste transduction_Homo sapiens_hsa04742	0.30110764
122	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.29916142
123	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.29870167
124	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.29388585

ERGIC3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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