

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 5.65893830 |
| 2 | ribosomal small subunit biogenesis (GO:0042274) | 5.53584032 |
| 3 | viral transcription (GO:0019083) | 5.45882721 |
| 4 | translational termination (GO:0006415) | 5.32005437 |
| 5 | maturation of SSU-rRNA (GO:0030490) | 5.19696693 |
| 6 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.69391242 |
| 7 | translational elongation (GO:0006414) | 4.66162949 |
| 8 | cotranslational protein targeting to membrane (GO:0006613) | 4.65072565 |
| 9 | proteasome assembly (GO:0043248) | 4.61308284 |
| 10 | protein targeting to ER (GO:0045047) | 4.59229381 |
| 11 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.54616020 |
| 12 | DNA deamination (GO:0045006) | 4.52130999 |
| 13 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.45196261 |
| 14 | ribosomal large subunit biogenesis (GO:0042273) | 4.44088695 |
| 15 | translational initiation (GO:0006413) | 4.40015528 |
| 16 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.36000043 |
| 17 | protein localization to endoplasmic reticulum (GO:0070972) | 4.34006658 |
| 18 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.33383501 |
| 19 | cellular protein complex disassembly (GO:0043624) | 4.26568341 |
| 20 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.26352195 |
| 21 | DNA strand elongation (GO:0022616) | 4.23382172 |
| 22 | viral life cycle (GO:0019058) | 4.21592255 |
| 23 | establishment of integrated proviral latency (GO:0075713) | 4.20093035 |
| 24 | ATP synthesis coupled proton transport (GO:0015986) | 4.19559393 |
| 25 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.19559393 |
| 26 | mitotic chromosome condensation (GO:0007076) | 4.16659567 |
| 27 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.14998255 |
| 28 | protein localization to kinetochore (GO:0034501) | 4.12931422 |
| 29 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.07412737 |
| 30 | protein localization to chromosome, centromeric region (GO:0071459) | 4.07306691 |
| 31 | spliceosomal snRNP assembly (GO:0000387) | 4.05870038 |
| 32 | formation of translation preinitiation complex (GO:0001731) | 4.00331904 |
| 33 | termination of RNA polymerase III transcription (GO:0006386) | 3.98214065 |
| 34 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.98214065 |
| 35 | DNA replication initiation (GO:0006270) | 3.98178971 |
| 36 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.88294204 |
| 37 | translation (GO:0006412) | 3.87071564 |
| 38 | telomere maintenance via recombination (GO:0000722) | 3.86281630 |
| 39 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.86245343 |
| 40 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.86173176 |
| 41 | CENP-A containing nucleosome assembly (GO:0034080) | 3.86070160 |
| 42 | negative regulation of ligase activity (GO:0051352) | 3.83888240 |
| 43 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.83888240 |
| 44 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.79049020 |
| 45 | protein complex disassembly (GO:0043241) | 3.77042463 |
| 46 | spliceosomal complex assembly (GO:0000245) | 3.76637064 |
| 47 | rRNA processing (GO:0006364) | 3.74572067 |
| 48 | chromatin remodeling at centromere (GO:0031055) | 3.73131478 |
| 49 | 7-methylguanosine mRNA capping (GO:0006370) | 3.71594148 |
| 50 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.71190927 |
| 51 | RNA capping (GO:0036260) | 3.68095979 |
| 52 | 7-methylguanosine RNA capping (GO:0009452) | 3.68095979 |
| 53 | mitotic sister chromatid segregation (GO:0000070) | 3.66672121 |
| 54 | DNA replication checkpoint (GO:0000076) | 3.66535369 |
| 55 | nucleobase biosynthetic process (GO:0046112) | 3.64989762 |
| 56 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.62728499 |
| 57 | rRNA modification (GO:0000154) | 3.62726113 |
| 58 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.62686689 |
| 59 | rRNA metabolic process (GO:0016072) | 3.60256957 |
| 60 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.59428181 |
| 61 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.59283688 |
| 62 | mitotic recombination (GO:0006312) | 3.58777063 |
| 63 | macromolecular complex disassembly (GO:0032984) | 3.58637386 |
| 64 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.56567392 |
| 65 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.56567392 |
| 66 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.56148663 |
| 67 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.53690063 |
| 68 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.53690063 |
| 69 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.53690063 |
| 70 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.50721387 |
| 71 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.48471733 |
| 72 | protein targeting to membrane (GO:0006612) | 3.47532175 |
| 73 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.46984281 |
| 74 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.46984281 |
| 75 | kinetochore assembly (GO:0051382) | 3.46653355 |
| 76 | kinetochore organization (GO:0051383) | 3.46480864 |
| 77 | purine nucleobase biosynthetic process (GO:0009113) | 3.45843918 |
| 78 | heterochromatin organization (GO:0070828) | 3.45458037 |
| 79 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.44883055 |
| 80 | pseudouridine synthesis (GO:0001522) | 3.44847212 |
| 81 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.44638768 |
| 82 | cullin deneddylation (GO:0010388) | 3.44381171 |
| 83 | telomere maintenance via telomere lengthening (GO:0010833) | 3.43368149 |
| 84 | cellular component biogenesis (GO:0044085) | 3.42100629 |
| 85 | DNA unwinding involved in DNA replication (GO:0006268) | 3.41535459 |
| 86 | viral mRNA export from host cell nucleus (GO:0046784) | 3.41318242 |
| 87 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.40866183 |
| 88 | DNA replication-independent nucleosome organization (GO:0034724) | 3.40104600 |
| 89 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.40104600 |
| 90 | ribosome biogenesis (GO:0042254) | 3.39753571 |
| 91 | mitotic metaphase plate congression (GO:0007080) | 3.37334386 |
| 92 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.36845543 |
| 93 | establishment of viral latency (GO:0019043) | 3.36643647 |
| 94 | sister chromatid segregation (GO:0000819) | 3.36219005 |
| 95 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.35027033 |
| 96 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.33291310 |
| 97 | protein deneddylation (GO:0000338) | 3.32640097 |
| 98 | regulation of translational fidelity (GO:0006450) | 3.32188164 |
| 99 | ribosome assembly (GO:0042255) | 3.27004051 |
| 100 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.26254079 |
| 101 | termination of RNA polymerase I transcription (GO:0006363) | 3.25714989 |
| 102 | mRNA catabolic process (GO:0006402) | 3.22427439 |
| 103 | GTP biosynthetic process (GO:0006183) | 3.21083096 |
| 104 | chaperone-mediated protein transport (GO:0072321) | 3.20095044 |
| 105 | cell cycle G1/S phase transition (GO:0044843) | 3.20034156 |
| 106 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.20034156 |
| 107 | metaphase plate congression (GO:0051310) | 3.19403868 |
| 108 | positive regulation of ligase activity (GO:0051351) | 3.19243545 |
| 109 | L-serine metabolic process (GO:0006563) | 3.16175427 |
| 110 | transcription from RNA polymerase I promoter (GO:0006360) | 3.15400404 |
| 111 | regulation of mitochondrial translation (GO:0070129) | 3.11532634 |
| 112 | UTP biosynthetic process (GO:0006228) | 3.10503433 |
| 113 | nuclear pore complex assembly (GO:0051292) | 3.09327152 |
| 114 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.09269315 |
| 115 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.09269315 |
| 116 | RNA catabolic process (GO:0006401) | 3.07106030 |
| 117 | DNA topological change (GO:0006265) | 2.98048919 |
| 118 | DNA ligation (GO:0006266) | 2.95943734 |
| 119 | protein complex localization (GO:0031503) | 2.95524812 |
| 120 | negative regulation of RNA splicing (GO:0033119) | 2.94256672 |
| 121 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.91444702 |
| 122 | chromatin assembly or disassembly (GO:0006333) | 2.90368656 |
| 123 | mitotic nuclear envelope disassembly (GO:0007077) | 2.85793519 |
| 124 | histone exchange (GO:0043486) | 2.83880240 |
| 125 | mRNA splicing, via spliceosome (GO:0000398) | 2.83657156 |
| 126 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.83657156 |
| 127 | termination of RNA polymerase II transcription (GO:0006369) | 2.82654771 |
| 128 | RNA splicing, via transesterification reactions (GO:0000375) | 2.81293686 |
| 129 | ATP-dependent chromatin remodeling (GO:0043044) | 2.80117602 |
| 130 | establishment of chromosome localization (GO:0051303) | 2.78165412 |
| 131 | chromosome condensation (GO:0030261) | 2.76549266 |
| 132 | peptidyl-arginine omega-N-methylation (GO:0035247) | 2.76499511 |
| 133 | IMP biosynthetic process (GO:0006188) | 2.75402948 |
| 134 | DNA damage response, detection of DNA damage (GO:0042769) | 2.74747247 |
| 135 | nuclear pore organization (GO:0006999) | 2.73722144 |
| 136 | regulation of chromosome segregation (GO:0051983) | 2.73326710 |
| 137 | protein maturation by protein folding (GO:0022417) | 2.71618240 |
| 138 | respiratory electron transport chain (GO:0022904) | 2.70382865 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.98611956 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.78541910 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.38738170 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.97065818 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.92343187 |
| 6 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.84532861 |
| 7 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.62444176 |
| 8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.57537585 |
| 9 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.46099530 |
| 10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.38638496 |
| 11 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.30073903 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.24772069 |
| 13 | * HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.21194703 |
| 14 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.19823825 |
| 15 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 3.07090100 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.03298482 |
| 17 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.97456032 |
| 18 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.85938843 |
| 19 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.83831642 |
| 20 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.69573573 |
| 21 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.67462812 |
| 22 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.64063481 |
| 23 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.61493191 |
| 24 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.54047496 |
| 25 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.39064974 |
| 26 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.34238403 |
| 27 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.28240047 |
| 28 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.22926114 |
| 29 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.22434190 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.15362536 |
| 31 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.13241216 |
| 32 | * ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.12013333 |
| 33 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.09510710 |
| 34 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.04857497 |
| 35 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.00458386 |
| 36 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.00071507 |
| 37 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.91523873 |
| 38 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.87615234 |
| 39 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.83421103 |
| 40 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.83072420 |
| 41 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.78717027 |
| 42 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.78543195 |
| 43 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.71455905 |
| 44 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.70256514 |
| 45 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.68847610 |
| 46 | * NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.66622416 |
| 47 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.60578619 |
| 48 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.59856120 |
| 49 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.59152470 |
| 50 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.57852060 |
| 51 | * E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.55226589 |
| 52 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.53663983 |
| 53 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.50966369 |
| 54 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.48880367 |
| 55 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.41476333 |
| 56 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.39795981 |
| 57 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.36467066 |
| 58 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.34464016 |
| 59 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.30805576 |
| 60 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.30147992 |
| 61 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.30014695 |
| 62 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.27852646 |
| 63 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.26372271 |
| 64 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.25092055 |
| 65 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.24214104 |
| 66 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.24100586 |
| 67 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.24063082 |
| 68 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.23174239 |
| 69 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.22833038 |
| 70 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.21966868 |
| 71 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.21775945 |
| 72 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.19323155 |
| 73 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.17100487 |
| 74 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.07322296 |
| 75 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.05544614 |
| 76 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.04722281 |
| 77 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.03541113 |
| 78 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.03406589 |
| 79 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.03072553 |
| 80 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.02925841 |
| 81 | * NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.02111122 |
| 82 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.00995037 |
| 83 | * MYC_22102868_ChIP-Seq_BL_Human | 0.98983425 |
| 84 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.98508881 |
| 85 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.97613407 |
| 86 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.97137947 |
| 87 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.97113438 |
| 88 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.96227174 |
| 89 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.93683885 |
| 90 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.91446466 |
| 91 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.88913840 |
| 92 | * SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.88122605 |
| 93 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.86855454 |
| 94 | * SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.86201439 |
| 95 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.83460400 |
| 96 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.80864948 |
| 97 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.80499030 |
| 98 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.78974279 |
| 99 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.78458181 |
| 100 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.78434361 |
| 101 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.78334371 |
| 102 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.77839031 |
| 103 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.77039425 |
| 104 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.76867008 |
| 105 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.76457657 |
| 106 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.76018807 |
| 107 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.74828216 |
| 108 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.74064318 |
| 109 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.73667746 |
| 110 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.72594312 |
| 111 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.71328984 |
| 112 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.70216888 |
| 113 | * NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.70208807 |
| 114 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.69979729 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.18369686 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.35011840 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.10919827 |
| 4 | MP0008057_abnormal_DNA_replication | 3.93065867 |
| 5 | MP0003111_abnormal_nucleus_morphology | 3.81536249 |
| 6 | MP0003077_abnormal_cell_cycle | 3.78476353 |
| 7 | MP0009379_abnormal_foot_pigmentation | 3.78106129 |
| 8 | MP0008058_abnormal_DNA_repair | 3.37458502 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.93383644 |
| 10 | MP0008007_abnormal_cellular_replicative | 2.70031648 |
| 11 | MP0003123_paternal_imprinting | 2.29681740 |
| 12 | MP0006292_abnormal_olfactory_placode | 2.29641471 |
| 13 | MP0003786_premature_aging | 2.26339560 |
| 14 | MP0003718_maternal_effect | 2.11201942 |
| 15 | MP0001529_abnormal_vocalization | 2.08672164 |
| 16 | MP0003315_abnormal_perineum_morphology | 1.87020195 |
| 17 | MP0002102_abnormal_ear_morphology | 1.85431747 |
| 18 | MP0008877_abnormal_DNA_methylation | 1.82400891 |
| 19 | MP0001730_embryonic_growth_arrest | 1.81584983 |
| 20 | MP0000350_abnormal_cell_proliferation | 1.81367575 |
| 21 | MP0002938_white_spotting | 1.78183945 |
| 22 | MP0003136_yellow_coat_color | 1.72731657 |
| 23 | MP0002697_abnormal_eye_size | 1.70284701 |
| 24 | MP0009672_abnormal_birth_weight | 1.65420040 |
| 25 | MP0009053_abnormal_anal_canal | 1.55475051 |
| 26 | MP0002396_abnormal_hematopoietic_system | 1.51138539 |
| 27 | MP0002877_abnormal_melanocyte_morpholog | 1.49384908 |
| 28 | MP0010030_abnormal_orbit_morphology | 1.45327551 |
| 29 | MP0009697_abnormal_copulation | 1.43457219 |
| 30 | MP0003806_abnormal_nucleotide_metabolis | 1.43301689 |
| 31 | MP0004133_heterotaxia | 1.42191524 |
| 32 | MP0003121_genomic_imprinting | 1.41474232 |
| 33 | MP0008789_abnormal_olfactory_epithelium | 1.37899835 |
| 34 | MP0010234_abnormal_vibrissa_follicle | 1.36816934 |
| 35 | MP0002132_abnormal_respiratory_system | 1.34750722 |
| 36 | MP0002092_abnormal_eye_morphology | 1.32601900 |
| 37 | MP0004185_abnormal_adipocyte_glucose | 1.31537832 |
| 38 | MP0000490_abnormal_crypts_of | 1.31439938 |
| 39 | MP0001697_abnormal_embryo_size | 1.30377999 |
| 40 | MP0006035_abnormal_mitochondrial_morpho | 1.30325036 |
| 41 | MP0001346_abnormal_lacrimal_gland | 1.28870821 |
| 42 | MP0005257_abnormal_intraocular_pressure | 1.25380199 |
| 43 | MP0000313_abnormal_cell_death | 1.25056291 |
| 44 | MP0001188_hyperpigmentation | 1.24325143 |
| 45 | MP0002210_abnormal_sex_determination | 1.23581631 |
| 46 | MP0001293_anophthalmia | 1.23478745 |
| 47 | MP0003567_abnormal_fetal_cardiomyocyte | 1.22706535 |
| 48 | MP0002080_prenatal_lethality | 1.22260312 |
| 49 | MP0003186_abnormal_redox_activity | 1.22231431 |
| 50 | MP0003705_abnormal_hypodermis_morpholog | 1.20320092 |
| 51 | MP0003942_abnormal_urinary_system | 1.20137591 |
| 52 | MP0001905_abnormal_dopamine_level | 1.19525579 |
| 53 | MP0003890_abnormal_embryonic-extraembry | 1.19438524 |
| 54 | MP0002085_abnormal_embryonic_tissue | 1.18015968 |
| 55 | MP0005501_abnormal_skin_physiology | 1.17743177 |
| 56 | MP0009333_abnormal_splenocyte_physiolog | 1.16728317 |
| 57 | MP0001672_abnormal_embryogenesis/_devel | 1.14505620 |
| 58 | MP0005380_embryogenesis_phenotype | 1.14505620 |
| 59 | MP0002163_abnormal_gland_morphology | 1.14435754 |
| 60 | MP0002233_abnormal_nose_morphology | 1.12132052 |
| 61 | MP0006036_abnormal_mitochondrial_physio | 1.10895963 |
| 62 | MP0000049_abnormal_middle_ear | 1.10350428 |
| 63 | MP0000762_abnormal_tongue_morphology | 1.10119136 |
| 64 | MP0002751_abnormal_autonomic_nervous | 1.09302778 |
| 65 | MP0001145_abnormal_male_reproductive | 1.06008126 |
| 66 | MP0002638_abnormal_pupillary_reflex | 1.03664348 |
| 67 | MP0000428_abnormal_craniofacial_morphol | 1.02390034 |
| 68 | MP0002160_abnormal_reproductive_system | 1.02031170 |
| 69 | MP0005174_abnormal_tail_pigmentation | 1.01877612 |
| 70 | MP0010352_gastrointestinal_tract_polyps | 1.00523499 |
| 71 | MP0000372_irregular_coat_pigmentation | 1.00159098 |
| 72 | MP0003755_abnormal_palate_morphology | 0.99985962 |
| 73 | MP0001727_abnormal_embryo_implantation | 0.98829862 |
| 74 | MP0002796_impaired_skin_barrier | 0.98392114 |
| 75 | MP0003385_abnormal_body_wall | 0.98066280 |
| 76 | MP0002019_abnormal_tumor_incidence | 0.98027963 |
| 77 | MP0010307_abnormal_tumor_latency | 0.97233318 |
| 78 | MP0002095_abnormal_skin_pigmentation | 0.96384089 |
| 79 | MP0000537_abnormal_urethra_morphology | 0.96110962 |
| 80 | MP0003984_embryonic_growth_retardation | 0.94132148 |
| 81 | MP0003938_abnormal_ear_development | 0.92809300 |
| 82 | MP0002084_abnormal_developmental_patter | 0.92759508 |
| 83 | MP0001929_abnormal_gametogenesis | 0.92120616 |
| 84 | MP0005499_abnormal_olfactory_system | 0.91929657 |
| 85 | MP0005394_taste/olfaction_phenotype | 0.91929657 |
| 86 | MP0000653_abnormal_sex_gland | 0.91410192 |
| 87 | MP0003937_abnormal_limbs/digits/tail_de | 0.91263200 |
| 88 | MP0002088_abnormal_embryonic_growth/wei | 0.90934818 |
| 89 | MP0000358_abnormal_cell_content/ | 0.90116418 |
| 90 | MP0000566_synostosis | 0.89585398 |
| 91 | MP0002234_abnormal_pharynx_morphology | 0.88763686 |
| 92 | MP0005408_hypopigmentation | 0.87706364 |
| 93 | MP0001881_abnormal_mammary_gland | 0.87135012 |
| 94 | MP0005075_abnormal_melanosome_morpholog | 0.85169791 |
| 95 | MP0001340_abnormal_eyelid_morphology | 0.84270743 |
| 96 | MP0001286_abnormal_eye_development | 0.84017183 |
| 97 | MP0006072_abnormal_retinal_apoptosis | 0.83117097 |
| 98 | MP0005623_abnormal_meninges_morphology | 0.81555766 |
| 99 | MP0005409_darkened_coat_color | 0.81087077 |
| 100 | MP0005389_reproductive_system_phenotype | 0.81042191 |
| 101 | MP0004233_abnormal_muscle_weight | 0.80953598 |
| 102 | MP0003941_abnormal_skin_development | 0.80743064 |
| 103 | MP0001485_abnormal_pinna_reflex | 0.80695311 |
| 104 | MP0001849_ear_inflammation | 0.79828956 |
| 105 | MP0009703_decreased_birth_body | 0.78753202 |
| 106 | MP0008995_early_reproductive_senescence | 0.78285696 |
| 107 | MP0002653_abnormal_ependyma_morphology | 0.77841205 |
| 108 | MP0000015_abnormal_ear_pigmentation | 0.77708247 |
| 109 | MP0006054_spinal_hemorrhage | 0.76792982 |
| 110 | MP0001299_abnormal_eye_distance/ | 0.74681854 |
| 111 | MP0004197_abnormal_fetal_growth/weight/ | 0.72705499 |
| 112 | MP0001348_abnormal_lacrimal_gland | 0.72477942 |
| 113 | MP0000432_abnormal_head_morphology | 0.71286041 |
| 114 | MP0003119_abnormal_digestive_system | 0.70074043 |
| 115 | MP0004808_abnormal_hematopoietic_stem | 0.68961701 |
| 116 | MP0002111_abnormal_tail_morphology | 0.68939538 |
| 117 | MP0004147_increased_porphyrin_level | 0.67598721 |
| 118 | MP0002081_perinatal_lethality | 0.67383721 |
| 119 | MP0001119_abnormal_female_reproductive | 0.67286717 |
| 120 | MP0003861_abnormal_nervous_system | 0.67258760 |
| 121 | MP0005197_abnormal_uvea_morphology | 0.67124491 |
| 122 | MP0000627_abnormal_mammary_gland | 0.67071885 |
| 123 | MP0002086_abnormal_extraembryonic_tissu | 0.66766104 |
| 124 | MP0002116_abnormal_craniofacial_bone | 0.66278888 |
| 125 | MP0005391_vision/eye_phenotype | 0.66125256 |
| 126 | MP0000703_abnormal_thymus_morphology | 0.65254517 |
| 127 | MP0002249_abnormal_larynx_morphology | 0.64900351 |
| 128 | MP0001986_abnormal_taste_sensitivity | 0.64538491 |
| 129 | MP0002282_abnormal_trachea_morphology | 0.63071770 |
| 130 | MP0000631_abnormal_neuroendocrine_gland | 0.61933808 |
| 131 | MP0003122_maternal_imprinting | 0.61734357 |
| 132 | MP0001853_heart_inflammation | 0.61553626 |
| 133 | MP0002722_abnormal_immune_system | 0.57018831 |
| 134 | MP0003221_abnormal_cardiomyocyte_apopto | 0.56713776 |
| 135 | MP0003763_abnormal_thymus_physiology | 0.56706471 |
| 136 | MP0001919_abnormal_reproductive_system | 0.56069933 |
| 137 | MP0002398_abnormal_bone_marrow | 0.55915099 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.87071809 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.50713864 |
| 3 | Reticulocytopenia (HP:0001896) | 5.17445647 |
| 4 | Birth length less than 3rd percentile (HP:0003561) | 4.65344936 |
| 5 | Acute necrotizing encephalopathy (HP:0006965) | 4.18175016 |
| 6 | Macrocytic anemia (HP:0001972) | 3.87759538 |
| 7 | Breast hypoplasia (HP:0003187) | 3.75758797 |
| 8 | Mitochondrial inheritance (HP:0001427) | 3.70571571 |
| 9 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.66837168 |
| 10 | Pallor (HP:0000980) | 3.65923883 |
| 11 | Aplastic anemia (HP:0001915) | 3.48027306 |
| 12 | Increased hepatocellular lipid droplets (HP:0006565) | 3.46586698 |
| 13 | Oral leukoplakia (HP:0002745) | 3.41520201 |
| 14 | Increased CSF lactate (HP:0002490) | 3.30562800 |
| 15 | Progressive macrocephaly (HP:0004481) | 3.28761868 |
| 16 | Cerebral hypomyelination (HP:0006808) | 3.20098658 |
| 17 | Increased serum pyruvate (HP:0003542) | 3.19511921 |
| 18 | Abnormality of glycolysis (HP:0004366) | 3.19511921 |
| 19 | Acute encephalopathy (HP:0006846) | 3.12132401 |
| 20 | Hepatocellular necrosis (HP:0001404) | 3.08617928 |
| 21 | Patellar aplasia (HP:0006443) | 3.07137249 |
| 22 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.05057426 |
| 23 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.98597605 |
| 24 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.98597605 |
| 25 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.95056775 |
| 26 | Rough bone trabeculation (HP:0100670) | 2.95018241 |
| 27 | 3-Methylglutaconic aciduria (HP:0003535) | 2.94147729 |
| 28 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.88404686 |
| 29 | Lipid accumulation in hepatocytes (HP:0006561) | 2.87622134 |
| 30 | Missing ribs (HP:0000921) | 2.74238923 |
| 31 | Colon cancer (HP:0003003) | 2.73018616 |
| 32 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.71176080 |
| 33 | Increased serum lactate (HP:0002151) | 2.70637594 |
| 34 | Carpal bone hypoplasia (HP:0001498) | 2.67333871 |
| 35 | Septo-optic dysplasia (HP:0100842) | 2.65116319 |
| 36 | Renal Fanconi syndrome (HP:0001994) | 2.64797797 |
| 37 | Exertional dyspnea (HP:0002875) | 2.61274903 |
| 38 | Increased nuchal translucency (HP:0010880) | 2.60322004 |
| 39 | Chromsome breakage (HP:0040012) | 2.55614634 |
| 40 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.55017405 |
| 41 | Premature graying of hair (HP:0002216) | 2.51891992 |
| 42 | Progressive muscle weakness (HP:0003323) | 2.49556353 |
| 43 | Hepatic necrosis (HP:0002605) | 2.47290355 |
| 44 | 11 pairs of ribs (HP:0000878) | 2.47006073 |
| 45 | Abnormality of the preputium (HP:0100587) | 2.46755211 |
| 46 | Meckel diverticulum (HP:0002245) | 2.44621923 |
| 47 | Exercise intolerance (HP:0003546) | 2.44261413 |
| 48 | Type I transferrin isoform profile (HP:0003642) | 2.39271420 |
| 49 | Abnormal number of incisors (HP:0011064) | 2.39023262 |
| 50 | Abnormality of the ileum (HP:0001549) | 2.38378987 |
| 51 | Absent thumb (HP:0009777) | 2.36969373 |
| 52 | Absent radius (HP:0003974) | 2.34875843 |
| 53 | Respiratory difficulties (HP:0002880) | 2.33866891 |
| 54 | Abnormal lung lobation (HP:0002101) | 2.32030560 |
| 55 | Selective tooth agenesis (HP:0001592) | 2.31473199 |
| 56 | Cerebral edema (HP:0002181) | 2.28583013 |
| 57 | Horseshoe kidney (HP:0000085) | 2.26324773 |
| 58 | Degeneration of anterior horn cells (HP:0002398) | 2.22326129 |
| 59 | Abnormality of the anterior horn cell (HP:0006802) | 2.22326129 |
| 60 | Duplicated collecting system (HP:0000081) | 2.22113036 |
| 61 | Supernumerary spleens (HP:0009799) | 2.21919526 |
| 62 | Absent forearm bone (HP:0003953) | 2.21278640 |
| 63 | Aplasia involving forearm bones (HP:0009822) | 2.21278640 |
| 64 | Triphalangeal thumb (HP:0001199) | 2.20562883 |
| 65 | Spastic diplegia (HP:0001264) | 2.18576983 |
| 66 | Microretrognathia (HP:0000308) | 2.18130657 |
| 67 | Abnormal trabecular bone morphology (HP:0100671) | 2.16610404 |
| 68 | Overriding aorta (HP:0002623) | 2.14661742 |
| 69 | Increased intramyocellular lipid droplets (HP:0012240) | 2.14149215 |
| 70 | Cellular immunodeficiency (HP:0005374) | 2.12607876 |
| 71 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.12064692 |
| 72 | Leukodystrophy (HP:0002415) | 2.11745605 |
| 73 | Cortical dysplasia (HP:0002539) | 2.11676943 |
| 74 | Multiple enchondromatosis (HP:0005701) | 2.10002240 |
| 75 | Absent septum pellucidum (HP:0001331) | 2.08299452 |
| 76 | Respiratory failure (HP:0002878) | 2.08183463 |
| 77 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.07951063 |
| 78 | Cleft eyelid (HP:0000625) | 2.07544846 |
| 79 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.07333206 |
| 80 | Glossoptosis (HP:0000162) | 2.06129037 |
| 81 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.04911002 |
| 82 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.04834166 |
| 83 | Congenital, generalized hypertrichosis (HP:0004540) | 2.04694714 |
| 84 | Abnormality of chromosome stability (HP:0003220) | 2.04172591 |
| 85 | Bone marrow hypocellularity (HP:0005528) | 2.02218760 |
| 86 | Lactic acidosis (HP:0003128) | 2.00463497 |
| 87 | Medulloblastoma (HP:0002885) | 1.99679223 |
| 88 | Insomnia (HP:0100785) | 1.99538851 |
| 89 | Secondary amenorrhea (HP:0000869) | 1.99280374 |
| 90 | Irregular epiphyses (HP:0010582) | 1.98589130 |
| 91 | Maternal diabetes (HP:0009800) | 1.98060188 |
| 92 | Abnormality of the septum pellucidum (HP:0007375) | 1.97609744 |
| 93 | Trismus (HP:0000211) | 1.97140389 |
| 94 | Duodenal stenosis (HP:0100867) | 1.96697504 |
| 95 | Small intestinal stenosis (HP:0012848) | 1.96697504 |
| 96 | Proximal placement of thumb (HP:0009623) | 1.96434935 |
| 97 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.96169125 |
| 98 | Pancytopenia (HP:0001876) | 1.95576229 |
| 99 | Abnormality of the renal collecting system (HP:0004742) | 1.94564565 |
| 100 | Myelodysplasia (HP:0002863) | 1.93709238 |
| 101 | Overlapping toe (HP:0001845) | 1.93188063 |
| 102 | Partial duplication of thumb phalanx (HP:0009944) | 1.91092479 |
| 103 | Broad distal phalanx of finger (HP:0009836) | 1.90943474 |
| 104 | Abnormality of the labia minora (HP:0012880) | 1.89731036 |
| 105 | Stenosis of the external auditory canal (HP:0000402) | 1.89697181 |
| 106 | Optic disc pallor (HP:0000543) | 1.88472397 |
| 107 | Hypoplastic pelvis (HP:0008839) | 1.88034730 |
| 108 | Embryonal renal neoplasm (HP:0011794) | 1.87166440 |
| 109 | Depressed nasal ridge (HP:0000457) | 1.86130475 |
| 110 | Rib fusion (HP:0000902) | 1.85470770 |
| 111 | CNS hypomyelination (HP:0003429) | 1.85253691 |
| 112 | Progressive external ophthalmoplegia (HP:0000590) | 1.85137358 |
| 113 | Duplication of thumb phalanx (HP:0009942) | 1.84897835 |
| 114 | Esophageal atresia (HP:0002032) | 1.84753039 |
| 115 | Microvesicular hepatic steatosis (HP:0001414) | 1.84187854 |
| 116 | Deviation of the thumb (HP:0009603) | 1.83166639 |
| 117 | Atresia of the external auditory canal (HP:0000413) | 1.82999216 |
| 118 | Abnormality of the carotid arteries (HP:0005344) | 1.82028357 |
| 119 | Muscle fiber atrophy (HP:0100295) | 1.81802862 |
| 120 | Microglossia (HP:0000171) | 1.81490396 |
| 121 | Abnormality of methionine metabolism (HP:0010901) | 1.80835165 |
| 122 | Neoplasm of the pancreas (HP:0002894) | 1.80640160 |
| 123 | Type 2 muscle fiber atrophy (HP:0003554) | 1.79693226 |
| 124 | Abnormality of reticulocytes (HP:0004312) | 1.79495069 |
| 125 | Pancreatic cysts (HP:0001737) | 1.79213973 |
| 126 | Asplenia (HP:0001746) | 1.78646330 |
| 127 | Facial cleft (HP:0002006) | 1.78232915 |
| 128 | Tracheoesophageal fistula (HP:0002575) | 1.77222031 |
| 129 | Gout (HP:0001997) | 1.76921573 |
| 130 | Hyperacusis (HP:0010780) | 1.76538944 |
| 131 | Elfin facies (HP:0004428) | 1.76017857 |
| 132 | Partial duplication of the phalanx of hand (HP:0009999) | 1.75453607 |
| 133 | Megaloblastic anemia (HP:0001889) | 1.74717540 |
| 134 | Renal duplication (HP:0000075) | 1.73176189 |
| 135 | Increased muscle lipid content (HP:0009058) | 1.69222180 |
| 136 | High anterior hairline (HP:0009890) | 1.69149814 |
| 137 | Thick lower lip vermilion (HP:0000179) | 1.69127232 |
| 138 | Sparse eyelashes (HP:0000653) | 1.68887012 |
| 139 | Amniotic constriction ring (HP:0009775) | 1.65203969 |
| 140 | Abnormality of placental membranes (HP:0011409) | 1.65203969 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.20448162 |
| 2 | VRK2 | 4.72496499 |
| 3 | WEE1 | 4.13288243 |
| 4 | STK16 | 3.59510921 |
| 5 | EIF2AK1 | 3.34300091 |
| 6 | SRPK1 | 3.16246674 |
| 7 | CDC7 | 3.12562898 |
| 8 | NME2 | 3.02883630 |
| 9 | VRK1 | 2.81857272 |
| 10 | TAF1 | 2.37507240 |
| 11 | EIF2AK3 | 2.35314554 |
| 12 | PLK4 | 2.31588433 |
| 13 | SMG1 | 2.14697124 |
| 14 | MKNK1 | 2.09767552 |
| 15 | TSSK6 | 2.07618801 |
| 16 | NME1 | 1.96446138 |
| 17 | BRSK2 | 1.89635484 |
| 18 | TESK2 | 1.88271321 |
| 19 | ACVR1B | 1.87329368 |
| 20 | DYRK3 | 1.81883198 |
| 21 | PLK1 | 1.68916976 |
| 22 | PBK | 1.63697142 |
| 23 | PIM2 | 1.61386052 |
| 24 | TTK | 1.61021869 |
| 25 | PLK3 | 1.52655651 |
| 26 | DYRK2 | 1.51336029 |
| 27 | CDK7 | 1.43991136 |
| 28 | TLK1 | 1.43698267 |
| 29 | MST4 | 1.42907453 |
| 30 | AURKB | 1.42667717 |
| 31 | NEK2 | 1.39827209 |
| 32 | PNCK | 1.38086648 |
| 33 | CCNB1 | 1.34173432 |
| 34 | EEF2K | 1.34027882 |
| 35 | RPS6KB2 | 1.29919461 |
| 36 | LATS2 | 1.28236452 |
| 37 | MAP3K9 | 1.28213844 |
| 38 | AURKA | 1.28025303 |
| 39 | PASK | 1.26299991 |
| 40 | MKNK2 | 1.26213879 |
| 41 | ATR | 1.24943659 |
| 42 | BRSK1 | 1.23649717 |
| 43 | TRIB3 | 1.19917197 |
| 44 | NEK1 | 1.17582108 |
| 45 | CDK8 | 1.16989387 |
| 46 | EIF2AK2 | 1.12647112 |
| 47 | MAP3K10 | 1.11529684 |
| 48 | CHEK2 | 1.09206300 |
| 49 | LIMK1 | 1.05779823 |
| 50 | BRAF | 0.94600127 |
| 51 | KDR | 0.90075218 |
| 52 | PAK4 | 0.89843351 |
| 53 | TGFBR1 | 0.87740702 |
| 54 | RPS6KA4 | 0.87260328 |
| 55 | IRAK3 | 0.85032001 |
| 56 | CHEK1 | 0.84512409 |
| 57 | ICK | 0.83526543 |
| 58 | * CSNK2A1 | 0.83161532 |
| 59 | TESK1 | 0.81770954 |
| 60 | * CSNK2A2 | 0.77520514 |
| 61 | TNIK | 0.77145612 |
| 62 | ZAK | 0.73237355 |
| 63 | EPHA2 | 0.72343073 |
| 64 | MAP3K8 | 0.71917829 |
| 65 | PRPF4B | 0.70241741 |
| 66 | PAK1 | 0.69910064 |
| 67 | ALK | 0.69251809 |
| 68 | ABL2 | 0.69023418 |
| 69 | MAP3K12 | 0.67543218 |
| 70 | EPHB2 | 0.67352007 |
| 71 | YES1 | 0.65882639 |
| 72 | ERBB4 | 0.64552738 |
| 73 | BCR | 0.64016542 |
| 74 | CDK19 | 0.63797629 |
| 75 | CSNK1G3 | 0.63628707 |
| 76 | DAPK3 | 0.62490445 |
| 77 | BMPR1B | 0.61188807 |
| 78 | MAPK13 | 0.61120864 |
| 79 | RPS6KA5 | 0.58976807 |
| 80 | UHMK1 | 0.58582411 |
| 81 | ATM | 0.56615241 |
| 82 | ILK | 0.55247066 |
| 83 | CDK2 | 0.54489665 |
| 84 | ADRBK2 | 0.53561445 |
| 85 | STK4 | 0.53447171 |
| 86 | CDK1 | 0.51218251 |
| 87 | LRRK2 | 0.50887673 |
| 88 | ARAF | 0.50138251 |
| 89 | MARK1 | 0.48247248 |
| 90 | PRKCI | 0.47417831 |
| 91 | MST1R | 0.43873605 |
| 92 | PIM1 | 0.43217190 |
| 93 | IRAK4 | 0.43072438 |
| 94 | CDK9 | 0.42943537 |
| 95 | CLK1 | 0.42033018 |
| 96 | CDK4 | 0.41689715 |
| 97 | STK3 | 0.39401315 |
| 98 | MAPKAPK5 | 0.38515302 |
| 99 | CDK11A | 0.38474231 |
| 100 | CDK12 | 0.37246261 |
| 101 | MAP2K7 | 0.37165840 |
| 102 | CDK18 | 0.36027699 |
| 103 | MYLK | 0.35945991 |
| 104 | ERBB3 | 0.35329952 |
| 105 | MAP3K11 | 0.35101290 |
| 106 | TAOK2 | 0.34592045 |
| 107 | CDK15 | 0.34276459 |
| 108 | CDK14 | 0.34102967 |
| 109 | PAK2 | 0.32762372 |
| 110 | MUSK | 0.32538370 |
| 111 | CDK6 | 0.32279323 |
| 112 | PRKDC | 0.31700067 |
| 113 | CSNK1G1 | 0.30712864 |
| 114 | FGFR1 | 0.28766210 |
| 115 | CSNK1E | 0.27396460 |
| 116 | DAPK1 | 0.27113803 |
| 117 | LYN | 0.26457135 |
| 118 | STK10 | 0.26444867 |
| 119 | GRK7 | 0.23856545 |
| 120 | SCYL2 | 0.23695325 |
| 121 | AKT2 | 0.21911680 |
| 122 | ADRBK1 | 0.21840154 |
| 123 | TEC | 0.21186898 |
| 124 | MELK | 0.20895861 |
| 125 | PLK2 | 0.20868814 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.09685519 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.57646796 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 4.35928894 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.97894869 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.75481302 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.37557522 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.19858122 |
| 8 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.80073111 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.79595751 |
| 10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.76086932 |
| 11 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.62731492 |
| 12 | RNA transport_Homo sapiens_hsa03013 | 2.60613334 |
| 13 | Base excision repair_Homo sapiens_hsa03410 | 2.58127928 |
| 14 | Parkinsons disease_Homo sapiens_hsa05012 | 2.46634529 |
| 15 | Huntingtons disease_Homo sapiens_hsa05016 | 2.06720692 |
| 16 | Cell cycle_Homo sapiens_hsa04110 | 2.05969626 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 2.00877163 |
| 18 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.98024486 |
| 19 | Protein export_Homo sapiens_hsa03060 | 1.93565406 |
| 20 | RNA degradation_Homo sapiens_hsa03018 | 1.89584043 |
| 21 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.83796431 |
| 22 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.79205548 |
| 23 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.70619570 |
| 24 | Alzheimers disease_Homo sapiens_hsa05010 | 1.56250934 |
| 25 | Purine metabolism_Homo sapiens_hsa00230 | 1.52997293 |
| 26 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.32951341 |
| 27 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.30427541 |
| 28 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.29959435 |
| 29 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.24332330 |
| 30 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.14604686 |
| 31 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.12621616 |
| 32 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.11977911 |
| 33 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.09217845 |
| 34 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.96238987 |
| 35 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.93875675 |
| 36 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.90355299 |
| 37 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.87468694 |
| 38 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.79908202 |
| 39 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.77432264 |
| 40 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.74628181 |
| 41 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.69891672 |
| 42 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.68300910 |
| 43 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.67932420 |
| 44 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.67897636 |
| 45 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.65446999 |
| 46 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.63787544 |
| 47 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.61415545 |
| 48 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.57767204 |
| 49 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.52661973 |
| 50 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.48881006 |
| 51 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.48713505 |
| 52 | Metabolic pathways_Homo sapiens_hsa01100 | 0.48219357 |
| 53 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.46537806 |
| 54 | Bladder cancer_Homo sapiens_hsa05219 | 0.46424500 |
| 55 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.44755407 |
| 56 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.44490632 |
| 57 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.44399739 |
| 58 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.43541410 |
| 59 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.42012573 |
| 60 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.41808199 |
| 61 | Adherens junction_Homo sapiens_hsa04520 | 0.40289553 |
| 62 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.40056898 |
| 63 | Sulfur relay system_Homo sapiens_hsa04122 | 0.39805733 |
| 64 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.38905847 |
| 65 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.37855621 |
| 66 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.36464984 |
| 67 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.33763547 |
| 68 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.33033037 |
| 69 | Alcoholism_Homo sapiens_hsa05034 | 0.31893256 |
| 70 | HTLV-I infection_Homo sapiens_hsa05166 | 0.31072855 |
| 71 | Asthma_Homo sapiens_hsa05310 | 0.28530590 |
| 72 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.26508724 |
| 73 | Allograft rejection_Homo sapiens_hsa05330 | 0.26330298 |
| 74 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.25977366 |
| 75 | Legionellosis_Homo sapiens_hsa05134 | 0.25692369 |
| 76 | Tight junction_Homo sapiens_hsa04530 | 0.25506151 |
| 77 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.24199495 |
| 78 | Galactose metabolism_Homo sapiens_hsa00052 | 0.23857995 |
| 79 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.22792475 |
| 80 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.21377636 |
| 81 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.20887746 |
| 82 | Melanoma_Homo sapiens_hsa05218 | 0.20258789 |
| 83 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.20241284 |
| 84 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.19291390 |
| 85 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.19267448 |
| 86 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.19097899 |
| 87 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.18757634 |
| 88 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.18732789 |
| 89 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.18505822 |
| 90 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.18261129 |
| 91 | Prostate cancer_Homo sapiens_hsa05215 | 0.17069719 |
| 92 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.16442439 |
| 93 | Phototransduction_Homo sapiens_hsa04744 | 0.16384575 |
| 94 | Prion diseases_Homo sapiens_hsa05020 | 0.16096992 |
| 95 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.15946319 |
| 96 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.14887019 |
| 97 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.14858061 |
| 98 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.14809911 |
| 99 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.14776736 |
| 100 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.13502442 |
| 101 | Carbon metabolism_Homo sapiens_hsa01200 | 0.13409257 |
| 102 | Shigellosis_Homo sapiens_hsa05131 | 0.12371534 |
| 103 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.12159520 |
| 104 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.11883554 |
| 105 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.11872012 |
| 106 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.10845346 |
| 107 | Thyroid cancer_Homo sapiens_hsa05216 | 0.09507175 |
| 108 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.09115070 |
| 109 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.08900895 |
| 110 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.08239578 |
| 111 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.07964022 |
| 112 | Apoptosis_Homo sapiens_hsa04210 | 0.07795818 |
| 113 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.07787600 |
| 114 | Colorectal cancer_Homo sapiens_hsa05210 | 0.07560389 |
| 115 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.07450975 |
| 116 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.07217472 |
| 117 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.06862560 |
| 118 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.06377024 |
| 119 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.05888570 |
| 120 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.04837697 |
| 121 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.03502124 |
| 122 | Pathways in cancer_Homo sapiens_hsa05200 | 0.03285072 |
| 123 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.02544679 |
| 124 | Measles_Homo sapiens_hsa05162 | 0.02439385 |
| 125 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.02371012 |

