ERI3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.87861360
2synaptic vesicle maturation (GO:0016188)5.44394777
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.10171080
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.00208181
5synaptic vesicle exocytosis (GO:0016079)4.94415025
6glutamate secretion (GO:0014047)4.93148060
7locomotory exploration behavior (GO:0035641)4.70863950
8regulation of synaptic vesicle exocytosis (GO:2000300)4.59160306
9regulation of synapse structural plasticity (GO:0051823)4.48044531
10regulation of glutamate receptor signaling pathway (GO:1900449)4.46566448
11vocalization behavior (GO:0071625)4.35555511
12regulation of synaptic vesicle transport (GO:1902803)4.33651387
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.31078546
14ribosomal small subunit assembly (GO:0000028)4.22604915
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.16250820
16regulation of mitochondrial translation (GO:0070129)4.05302205
17neurotransmitter-gated ion channel clustering (GO:0072578)4.02048131
18positive regulation of synapse maturation (GO:0090129)3.98840721
19regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.90710208
20protein localization to synapse (GO:0035418)3.88564338
21postsynaptic membrane organization (GO:0001941)3.85191648
22neurotransmitter secretion (GO:0007269)3.82731720
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.76773563
24exploration behavior (GO:0035640)3.74746710
25protein maturation by protein folding (GO:0022417)3.74043512
26regulation of neuronal synaptic plasticity (GO:0048168)3.71641350
27neuronal action potential propagation (GO:0019227)3.71550850
28establishment of integrated proviral latency (GO:0075713)3.67974365
29L-serine metabolic process (GO:0006563)3.67330568
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.66827752
31pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.63117766
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.62668152
33synaptic transmission, glutamatergic (GO:0035249)3.61990899
34pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.59966374
35regulation of NFAT protein import into nucleus (GO:0051532)3.48697173
36proteasome assembly (GO:0043248)3.48077447
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47908470
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.47755054
39guanosine-containing compound biosynthetic process (GO:1901070)3.47636550
40pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.45959764
41cell communication by electrical coupling (GO:0010644)3.45706977
42CTP metabolic process (GO:0046036)3.43565289
43CTP biosynthetic process (GO:0006241)3.43565289
44positive regulation of synaptic transmission, GABAergic (GO:0032230)3.43554721
45negative regulation of microtubule polymerization (GO:0031115)3.42553808
46UTP biosynthetic process (GO:0006228)3.40127962
47formation of translation preinitiation complex (GO:0001731)3.36744972
48GTP biosynthetic process (GO:0006183)3.36249805
49protein targeting to mitochondrion (GO:0006626)3.34529800
50activation of protein kinase A activity (GO:0034199)3.34101713
51DNA strand elongation involved in DNA replication (GO:0006271)3.33631039
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.33286397
53proline transport (GO:0015824)3.33050488
54establishment of viral latency (GO:0019043)3.32305627
55pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.30177641
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.30109972
57tricarboxylic acid cycle (GO:0006099)3.26930455
58synaptic vesicle endocytosis (GO:0048488)3.26430560
59neuron cell-cell adhesion (GO:0007158)3.25309455
60cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25216890
61ATP synthesis coupled proton transport (GO:0015986)3.24857853
62energy coupled proton transport, down electrochemical gradient (GO:0015985)3.24857853
63cerebellar Purkinje cell layer development (GO:0021680)3.23821406
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23773257
65positive regulation of neurotransmitter secretion (GO:0001956)3.23545780
66positive regulation of neurotransmitter transport (GO:0051590)3.22618890
67protein deneddylation (GO:0000338)3.22256910
68nucleobase-containing small molecule interconversion (GO:0015949)3.21503718
69regulation of synapse maturation (GO:0090128)3.21378914
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.20941986
71DNA strand elongation (GO:0022616)3.19631312
72neuron-neuron synaptic transmission (GO:0007270)3.19626085
73UTP metabolic process (GO:0046051)3.19125923
74cullin deneddylation (GO:0010388)3.19049939
75layer formation in cerebral cortex (GO:0021819)3.17464451
76establishment of protein localization to mitochondrion (GO:0072655)3.15647196
77ribosomal small subunit biogenesis (GO:0042274)3.15021344
78ionotropic glutamate receptor signaling pathway (GO:0035235)3.10788539
79regulation of neurotransmitter secretion (GO:0046928)3.09388337
80respiratory electron transport chain (GO:0022904)3.09306581
81ribosomal large subunit biogenesis (GO:0042273)3.08787270
82negative regulation of ligase activity (GO:0051352)3.07568758
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07568758
84oxidative phosphorylation (GO:0006119)3.04741242
85telomere maintenance via semi-conservative replication (GO:0032201)3.03236602
86electron transport chain (GO:0022900)3.02731384
87negative regulation of dendrite morphogenesis (GO:0050774)3.02004409
88cell migration in hindbrain (GO:0021535)3.01814294
89histone arginine methylation (GO:0034969)3.00621643
90protein complex biogenesis (GO:0070271)2.98581083
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96969733
92gamma-aminobutyric acid transport (GO:0015812)2.96118902
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95491630
94long-term memory (GO:0007616)2.94477167
95regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.93143045
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93127653
972-deoxyribonucleotide biosynthetic process (GO:0009265)2.93115177
98deoxyribose phosphate biosynthetic process (GO:0046385)2.93115177
99positive regulation of membrane potential (GO:0045838)2.91850977
100protein localization to mitochondrion (GO:0070585)2.91847491
101base-excision repair, AP site formation (GO:0006285)2.91832042
102pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.91408203
103NADH metabolic process (GO:0006734)2.91098035
104maturation of SSU-rRNA (GO:0030490)2.90565413
105pyrimidine nucleobase catabolic process (GO:0006208)2.88955429
106mitochondrial respiratory chain complex assembly (GO:0033108)2.87637811
107inner mitochondrial membrane organization (GO:0007007)2.86510601
108peptidyl-arginine omega-N-methylation (GO:0035247)2.86397910
109regulation of neurotransmitter transport (GO:0051588)2.85976869
110DNA unwinding involved in DNA replication (GO:0006268)2.84870875
111NADH dehydrogenase complex assembly (GO:0010257)2.84350567
112mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84350567
113mitochondrial respiratory chain complex I assembly (GO:0032981)2.84350567
114regulation of membrane repolarization (GO:0060306)2.84293345
115metallo-sulfur cluster assembly (GO:0031163)2.84109441
116iron-sulfur cluster assembly (GO:0016226)2.84109441
117aldehyde catabolic process (GO:0046185)2.83904078
118termination of RNA polymerase III transcription (GO:0006386)2.83664717
119transcription elongation from RNA polymerase III promoter (GO:0006385)2.83664717
120cardiac myofibril assembly (GO:0055003)2.83609396
121respiratory chain complex IV assembly (GO:0008535)2.82548277
122regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.82270523
123regulation of synaptic plasticity (GO:0048167)2.79895355
124cellular component biogenesis (GO:0044085)2.78869703
125regulation of translational fidelity (GO:0006450)2.77103335
126nuclear envelope reassembly (GO:0031468)2.75425913
127mitotic nuclear envelope reassembly (GO:0007084)2.75425913
128response to pheromone (GO:0019236)2.74869740
129viral transcription (GO:0019083)2.74219818
130negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72921490
131ribonucleoprotein complex biogenesis (GO:0022613)2.72563022
132neuromuscular synaptic transmission (GO:0007274)2.72498613
133regulation of cellular respiration (GO:0043457)2.72497681
134membrane depolarization during action potential (GO:0086010)2.72267681
135positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.71478902
136neurotransmitter transport (GO:0006836)2.70975829
137neuromuscular process controlling posture (GO:0050884)2.70805948
138regulation of synaptic transmission, GABAergic (GO:0032228)2.70743710
139regulation of cellular amino acid metabolic process (GO:0006521)2.69171457
140translation (GO:0006412)2.68188802
141peptidyl-arginine N-methylation (GO:0035246)2.67966005
142peptidyl-arginine methylation (GO:0018216)2.67966005
143positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.67953596
144tRNA aminoacylation for protein translation (GO:0006418)2.67845913
145regulation of excitatory postsynaptic membrane potential (GO:0060079)2.66789545
146spliceosomal snRNP assembly (GO:0000387)2.66467767
147negative regulation of dendrite development (GO:2000171)2.66336085
148synaptic vesicle transport (GO:0048489)2.65497992
149establishment of synaptic vesicle localization (GO:0097480)2.65497992
150translational elongation (GO:0006414)2.65374551
151proline biosynthetic process (GO:0006561)2.65090198
152negative regulation of cell size (GO:0045792)2.64988326
153tRNA aminoacylation (GO:0043039)2.64341917
154amino acid activation (GO:0043038)2.64341917
155chaperone-mediated protein transport (GO:0072321)2.63747421
156pyrimidine nucleotide biosynthetic process (GO:0006221)2.62635599
157axon cargo transport (GO:0008088)2.61646021
158Golgi transport vesicle coating (GO:0048200)2.61213428
159COPI coating of Golgi vesicle (GO:0048205)2.61213428
160mitochondrion transport along microtubule (GO:0047497)2.61171996
161establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.61171996
162response to auditory stimulus (GO:0010996)2.61143415
163purine nucleobase biosynthetic process (GO:0009113)2.60650957
164deoxyribonucleotide biosynthetic process (GO:0009263)2.59878091
165dopamine receptor signaling pathway (GO:0007212)2.59875246
166neuromuscular process controlling balance (GO:0050885)2.59795391
167regulation of neurotransmitter levels (GO:0001505)2.59599670
168pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.59458776
169translational termination (GO:0006415)2.59411229
170peptidyl-histidine modification (GO:0018202)2.58863363
171cerebellum development (GO:0021549)2.58162158
172ribonucleoside triphosphate biosynthetic process (GO:0009201)2.57159831
173positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.56984914
174membrane repolarization (GO:0086009)2.56737564
175SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.55839379
176auditory behavior (GO:0031223)2.55771275
177adult walking behavior (GO:0007628)2.55770049
178regulation of ubiquitin-protein transferase activity (GO:0051438)2.55338973
179rRNA modification (GO:0000154)2.54940393
180cytochrome complex assembly (GO:0017004)2.54935510
181positive regulation of synaptic transmission (GO:0050806)2.54045309
182cardiac muscle contraction (GO:0060048)2.53321463
183axonal fasciculation (GO:0007413)2.53252817
184regulation of synaptic transmission, glutamatergic (GO:0051966)2.53173225
185ribosome biogenesis (GO:0042254)2.52672753
186oxaloacetate metabolic process (GO:0006107)2.51909936
187positive regulation of ligase activity (GO:0051351)2.51860041
188cotranslational protein targeting to membrane (GO:0006613)2.51009717
189DNA damage response, detection of DNA damage (GO:0042769)2.50989405
190membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.49814001
191neuromuscular process (GO:0050905)2.49705009
192regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.48864760
193innervation (GO:0060384)2.48060613
194regulation of postsynaptic membrane potential (GO:0060078)2.47811168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.09765679
2E2F7_22180533_ChIP-Seq_HELA_Human4.10410142
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.83644557
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.64484401
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58979115
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.37947103
7GBX2_23144817_ChIP-Seq_PC3_Human2.98550409
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.97679481
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.89072607
10REST_18959480_ChIP-ChIP_MESCs_Mouse2.77879549
11REST_21632747_ChIP-Seq_MESCs_Mouse2.71202541
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70249962
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69057109
14XRN2_22483619_ChIP-Seq_HELA_Human2.68451500
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.64313423
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.62314289
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57372094
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.51958222
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51526998
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49400958
21ZFP281_18757296_ChIP-ChIP_E14_Mouse2.44107084
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.42037326
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.38826113
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.36607578
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35593075
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33954423
27JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31598280
28RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22774893
29EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22774893
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20758215
31EZH2_27304074_Chip-Seq_ESCs_Mouse2.19252182
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.18484743
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15048275
34GABP_19822575_ChIP-Seq_HepG2_Human2.14644320
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14133914
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11037261
37DCP1A_22483619_ChIP-Seq_HELA_Human2.10169483
38NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09984520
39EZH2_27294783_Chip-Seq_ESCs_Mouse2.09977013
40RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09512324
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.04558181
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01955950
43DROSHA_22980978_ChIP-Seq_HELA_Human2.01611663
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98604525
45TTF2_22483619_ChIP-Seq_HELA_Human1.97717843
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95393758
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94254190
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90532282
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89556191
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.88913477
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.88067397
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83017727
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82707122
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.81324093
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75518448
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71002283
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.69378655
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69254268
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.68100257
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.68077545
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.67721450
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64478021
63ZNF263_19887448_ChIP-Seq_K562_Human1.64385608
64FOXP3_21729870_ChIP-Seq_TREG_Human1.62863167
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60811271
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55832301
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55509113
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.53958362
69* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.53259089
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52395766
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52181608
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51405651
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51358157
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.49579156
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49544498
76LXR_22292898_ChIP-Seq_THP-1_Human1.49126320
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41097964
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37473563
79VDR_23849224_ChIP-Seq_CD4+_Human1.37108185
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36292193
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36038214
82KDM5A_27292631_Chip-Seq_BREAST_Human1.35384258
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.34640134
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34513661
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33890422
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33826402
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31988101
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30074848
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29737048
90* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29546018
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28944172
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28923209
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28458426
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.28197050
95CTCF_27219007_Chip-Seq_Bcells_Human1.27803680
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25944191
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.23907511
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22784250
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.21395681
100TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20687585
101FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18923424
102TET1_21490601_ChIP-Seq_MESCs_Mouse1.18014294
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16951869
104TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16821297
105OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16008616
106BCL6_27268052_Chip-Seq_Bcells_Human1.15047742
107TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.14562040
108CIITA_25753668_ChIP-Seq_RAJI_Human1.14136786
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13360526
110SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13205165
111P68_20966046_ChIP-Seq_HELA_Human1.12683903
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11379595
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.10315665
114PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09484640
115ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09223431
116JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08778513
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08120590
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07666190
119YY1_22570637_ChIP-Seq_MALME-3M_Human1.07471836
120KDM2B_26808549_Chip-Seq_K562_Human1.07185538
121* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06840135
122FOXM1_23109430_ChIP-Seq_U2OS_Human1.06739230
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03824633
124SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03140418
125ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02877104
126* SMC4_20622854_ChIP-Seq_HELA_Human1.02749379
127ZNF274_21170338_ChIP-Seq_K562_Hela1.01168426
128MYC_18940864_ChIP-ChIP_HL60_Human1.01079947
129ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00194564
130HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98986445
131* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98975047
132CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98875899
133TP53_23651856_ChIP-Seq_MEFs_Mouse0.98033720
134ELF1_20517297_ChIP-Seq_JURKAT_Human0.97854321
135OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97516213
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96981857
137SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96223000
138* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95543888
139ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94154049
140* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92297952
141THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91657176
142OCT4_19829295_ChIP-Seq_ESCs_Human0.91410164
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91186407
144ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90158295
145TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88589212
146FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88512459
147ELK1_19687146_ChIP-ChIP_HELA_Human0.88020436
148FOXP1_21924763_ChIP-Seq_HESCs_Human0.87968267
149PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87510924
150MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87299704
151ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86822663
152UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86702790
153TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.86676914
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86047578
155SOX3_22085726_ChIP-Seq_NPCs_Mouse0.83342944
156DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82891771
157NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81878415
158AR_19668381_ChIP-Seq_PC3_Human0.81387421
159* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78662733
160SOX2_21211035_ChIP-Seq_LN229_Gbm0.78093663
161* ETS1_20019798_ChIP-Seq_JURKAT_Human0.77881292
162PHF8_20622854_ChIP-Seq_HELA_Human0.77719424
163MYC_18358816_ChIP-ChIP_MESCs_Mouse0.76431272
164NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75744615
165KLF4_19829295_ChIP-Seq_ESCs_Human0.75292553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.75890933
2MP0003635_abnormal_synaptic_transmissio3.50696870
3MP0003880_abnormal_central_pattern3.16123123
4MP0004270_analgesia2.91508233
5MP0000751_myopathy2.89963421
6MP0002822_catalepsy2.81900408
7MP0002063_abnormal_learning/memory/cond2.79273042
8MP0001968_abnormal_touch/_nociception2.72227978
9MP0009745_abnormal_behavioral_response2.62950307
10MP0010030_abnormal_orbit_morphology2.51029759
11MP0008058_abnormal_DNA_repair2.45889992
12MP0002064_seizures2.42639571
13MP0009046_muscle_twitch2.37711860
14MP0002735_abnormal_chemical_nociception2.35787440
15MP0002736_abnormal_nociception_after2.31531022
16MP0003693_abnormal_embryo_hatching2.30925378
17MP0004858_abnormal_nervous_system2.29740526
18MP0009379_abnormal_foot_pigmentation2.27380751
19MP0002734_abnormal_mechanical_nocicepti2.24197455
20MP0010094_abnormal_chromosome_stability2.23466651
21MP0009780_abnormal_chondrocyte_physiolo2.23412656
22MP0003122_maternal_imprinting2.16487275
23MP0008932_abnormal_embryonic_tissue2.15431296
24MP0003111_abnormal_nucleus_morphology2.13043792
25MP0003646_muscle_fatigue2.12417992
26MP0005646_abnormal_pituitary_gland2.10063429
27MP0002572_abnormal_emotion/affect_behav2.09464326
28MP0004145_abnormal_muscle_electrophysio2.05689088
29MP0002837_dystrophic_cardiac_calcinosis1.99827234
30MP0000749_muscle_degeneration1.95876870
31MP0006036_abnormal_mitochondrial_physio1.95673797
32MP0004957_abnormal_blastocyst_morpholog1.91916947
33MP0004811_abnormal_neuron_physiology1.90897996
34MP0002733_abnormal_thermal_nociception1.86373371
35MP0002272_abnormal_nervous_system1.85819410
36MP0002909_abnormal_adrenal_gland1.76252138
37MP0001970_abnormal_pain_threshold1.73505828
38MP0003077_abnormal_cell_cycle1.71890963
39MP0008789_abnormal_olfactory_epithelium1.70877271
40MP0005623_abnormal_meninges_morphology1.70873833
41MP0004233_abnormal_muscle_weight1.70479192
42MP0006292_abnormal_olfactory_placode1.69366958
43MP0005423_abnormal_somatic_nervous1.63442510
44MP0008569_lethality_at_weaning1.62929480
45MP0002184_abnormal_innervation1.62145380
46MP0000955_abnormal_spinal_cord1.59419153
47MP0000778_abnormal_nervous_system1.56580744
48MP0000537_abnormal_urethra_morphology1.56408770
49MP0005645_abnormal_hypothalamus_physiol1.56224842
50MP0003186_abnormal_redox_activity1.54966701
51MP0000013_abnormal_adipose_tissue1.52578705
52MP0003786_premature_aging1.50612178
53MP0006035_abnormal_mitochondrial_morpho1.48419924
54MP0002067_abnormal_sensory_capabilities1.46542165
55MP0002557_abnormal_social/conspecific_i1.45738060
56MP0003787_abnormal_imprinting1.44108122
57MP0004924_abnormal_behavior1.42269471
58MP0005386_behavior/neurological_phenoty1.42269471
59MP0001486_abnormal_startle_reflex1.40745920
60MP0001346_abnormal_lacrimal_gland1.40143792
61MP0003879_abnormal_hair_cell1.39225439
62MP0006276_abnormal_autonomic_nervous1.38094820
63MP0008007_abnormal_cellular_replicative1.36770777
64MP0000372_irregular_coat_pigmentation1.35220546
65MP0003806_abnormal_nucleotide_metabolis1.33888941
66MP0004215_abnormal_myocardial_fiber1.28642029
67MP0003283_abnormal_digestive_organ1.28538033
68MP0004147_increased_porphyrin_level1.23723167
69MP0002882_abnormal_neuron_morphology1.23348735
70MP0004084_abnormal_cardiac_muscle1.22010789
71MP0002638_abnormal_pupillary_reflex1.21371932
72MP0002066_abnormal_motor_capabilities/c1.21156410
73MP0004142_abnormal_muscle_tone1.19632570
74MP0002102_abnormal_ear_morphology1.19272870
75MP0002269_muscular_atrophy1.18564208
76MP0000049_abnormal_middle_ear1.18123674
77MP0001293_anophthalmia1.17060074
78MP0000566_synostosis1.16435659
79MP0004036_abnormal_muscle_relaxation1.16219351
80MP0003123_paternal_imprinting1.11366735
81MP0001984_abnormal_olfaction1.09698620
82MP0003137_abnormal_impulse_conducting1.08855937
83MP0003329_amyloid_beta_deposits1.08502970
84MP0002249_abnormal_larynx_morphology1.08264872
85MP0000747_muscle_weakness1.07861579
86MP0002653_abnormal_ependyma_morphology1.06996797
87MP0001529_abnormal_vocalization1.06394621
88MP0005171_absent_coat_pigmentation1.06025015
89MP0000759_abnormal_skeletal_muscle1.03921649
90MP0001661_extended_life_span1.03570748
91MP0002751_abnormal_autonomic_nervous1.02930550
92MP0004085_abnormal_heartbeat1.01055307
93MP0002152_abnormal_brain_morphology1.00509111
94MP0003136_yellow_coat_color1.00107718
95MP0010386_abnormal_urinary_bladder0.98862063
96MP0003633_abnormal_nervous_system0.98784443
97MP0000358_abnormal_cell_content/0.96703346
98MP0005620_abnormal_muscle_contractility0.96616565
99MP0003718_maternal_effect0.96329474
100MP0001440_abnormal_grooming_behavior0.95743006
101MP0001188_hyperpigmentation0.95290833
102MP0003385_abnormal_body_wall0.93302709
103MP0002233_abnormal_nose_morphology0.92913182
104MP0000631_abnormal_neuroendocrine_gland0.92617879
105MP0000534_abnormal_ureter_morphology0.92297735
106MP0004087_abnormal_muscle_fiber0.91259684
107MP0001177_atelectasis0.90865422
108MP0001905_abnormal_dopamine_level0.90634007
109MP0000350_abnormal_cell_proliferation0.89643285
110MP0005394_taste/olfaction_phenotype0.89586060
111MP0005499_abnormal_olfactory_system0.89586060
112MP0003121_genomic_imprinting0.89033183
113MP0002089_abnormal_postnatal_growth/wei0.88598662
114MP0001730_embryonic_growth_arrest0.88041362
115MP0002938_white_spotting0.87508252
116MP0009672_abnormal_birth_weight0.87452444
117MP0005670_abnormal_white_adipose0.86965179
118MP0009053_abnormal_anal_canal0.86581335
119MP0002972_abnormal_cardiac_muscle0.85968066
120MP0002106_abnormal_muscle_physiology0.85700597
121MP0002160_abnormal_reproductive_system0.83624230
122MP0005369_muscle_phenotype0.83220386
123MP0005330_cardiomyopathy0.82944852
124MP0004130_abnormal_muscle_cell0.82081697
125MP0003937_abnormal_limbs/digits/tail_de0.81916055
126MP0001299_abnormal_eye_distance/0.81101627
127MP0003942_abnormal_urinary_system0.80038080
128MP0000678_abnormal_parathyroid_gland0.79726844
129MP0003119_abnormal_digestive_system0.79149112
130MP0001501_abnormal_sleep_pattern0.79030869
131MP0003631_nervous_system_phenotype0.78759070
132MP0002080_prenatal_lethality0.78493664
133MP0001502_abnormal_circadian_rhythm0.77056372
134MP0003315_abnormal_perineum_morphology0.75711415
135MP0002069_abnormal_eating/drinking_beha0.75365082
136MP0002085_abnormal_embryonic_tissue0.75206195
137MP0002234_abnormal_pharynx_morphology0.74225294
138MP0000762_abnormal_tongue_morphology0.70120612
139MP0005503_abnormal_tendon_morphology0.68475649
140MP0008872_abnormal_physiological_respon0.65388352
141MP0004133_heterotaxia0.65377858
142MP0003861_abnormal_nervous_system0.63550755
143MP0002108_abnormal_muscle_morphology0.62259410
144MP0003634_abnormal_glial_cell0.61300592
145MP0008877_abnormal_DNA_methylation0.61041124
146MP0002229_neurodegeneration0.60467558
147MP0010769_abnormal_survival0.60374063

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.38597728
2Focal motor seizures (HP:0011153)4.51601791
3Pheochromocytoma (HP:0002666)4.11316788
4Acute encephalopathy (HP:0006846)3.96456518
5Mitochondrial inheritance (HP:0001427)3.77139305
6Abnormality of glycolysis (HP:0004366)3.74043737
7Epileptic encephalopathy (HP:0200134)3.73329831
8Neuroendocrine neoplasm (HP:0100634)3.67382313
9Ankle clonus (HP:0011448)3.47078788
10Hepatic necrosis (HP:0002605)3.46889703
11Increased CSF lactate (HP:0002490)3.42594855
12Progressive macrocephaly (HP:0004481)3.39904585
13Increased serum pyruvate (HP:0003542)3.28699756
14Visual hallucinations (HP:0002367)3.24681546
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.19201118
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.19201118
17Abnormality of the lower motor neuron (HP:0002366)3.16773920
18Microvesicular hepatic steatosis (HP:0001414)3.09239499
19Neoplasm of the peripheral nervous system (HP:0100007)3.09197726
20Cholecystitis (HP:0001082)3.04591622
21Abnormal gallbladder physiology (HP:0012438)3.04591622
22Focal seizures (HP:0007359)3.02431312
23Cerebral edema (HP:0002181)2.95534634
24Impaired vibration sensation in the lower limbs (HP:0002166)2.92616821
25Exercise-induced myalgia (HP:0003738)2.77849591
26Lactic acidosis (HP:0003128)2.75811694
27Atonic seizures (HP:0010819)2.67284693
28Exercise intolerance (HP:0003546)2.67227929
29Depression (HP:0000716)2.63162984
30Increased serum lactate (HP:0002151)2.61767758
31Increased intramyocellular lipid droplets (HP:0012240)2.61761898
32Myotonia (HP:0002486)2.57867696
33Type I transferrin isoform profile (HP:0003642)2.57296257
34Torticollis (HP:0000473)2.55850562
35Febrile seizures (HP:0002373)2.55329004
36Focal dystonia (HP:0004373)2.55092256
37Reticulocytopenia (HP:0001896)2.54782740
38Urinary bladder sphincter dysfunction (HP:0002839)2.54059550
39Respiratory failure (HP:0002878)2.52628636
40Progressive cerebellar ataxia (HP:0002073)2.50658720
41Poor suck (HP:0002033)2.43298977
42Spinal canal stenosis (HP:0003416)2.42898519
43Craniofacial dystonia (HP:0012179)2.42660279
44Anxiety (HP:0000739)2.42503201
45Polyphagia (HP:0002591)2.42186837
46Abnormal eating behavior (HP:0100738)2.41455330
47Pointed chin (HP:0000307)2.37759115
48Poor eye contact (HP:0000817)2.35640372
49Failure to thrive in infancy (HP:0001531)2.33542694
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.32774781
51Neoplasm of the heart (HP:0100544)2.32341793
52Leukodystrophy (HP:0002415)2.31686460
53Impaired pain sensation (HP:0007328)2.31298664
54Abnormality of pain sensation (HP:0010832)2.31298664
55Increased hepatocellular lipid droplets (HP:0006565)2.31252798
56Increased muscle lipid content (HP:0009058)2.30359502
57Bundle branch block (HP:0011710)2.29857042
58Abnormal number of erythroid precursors (HP:0012131)2.29336614
59Abnormality of cells of the erythroid lineage (HP:0012130)2.29159176
60Hyperventilation (HP:0002883)2.28445208
61Emotional lability (HP:0000712)2.25220770
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25216026
63Abnormal protein N-linked glycosylation (HP:0012347)2.25216026
64Abnormal protein glycosylation (HP:0012346)2.25216026
65Abnormal glycosylation (HP:0012345)2.25216026
66CNS hypomyelination (HP:0003429)2.24289196
67Exercise-induced muscle cramps (HP:0003710)2.23838304
68Sleep apnea (HP:0010535)2.22864556
69Ragged-red muscle fibers (HP:0003200)2.22046325
70Shoulder girdle muscle weakness (HP:0003547)2.21786435
71Neoplasm of the adrenal gland (HP:0100631)2.20581892
72Hypoventilation (HP:0002791)2.20357784
73Lipid accumulation in hepatocytes (HP:0006561)2.20267607
74Ventricular fibrillation (HP:0001663)2.19175453
75Abnormal EKG (HP:0003115)2.18591329
76Generalized tonic-clonic seizures (HP:0002069)2.18280256
77Progressive muscle weakness (HP:0003323)2.18023286
78Degeneration of anterior horn cells (HP:0002398)2.14205862
79Abnormality of the anterior horn cell (HP:0006802)2.14205862
80Hamartoma of the eye (HP:0010568)2.12862808
81Urinary urgency (HP:0000012)2.12794721
82Broad-based gait (HP:0002136)2.12743786
83Epileptiform EEG discharges (HP:0011182)2.12065704
84Testicular atrophy (HP:0000029)2.11740798
85Microretrognathia (HP:0000308)2.11400313
86Sudden death (HP:0001699)2.11274022
87Insomnia (HP:0100785)2.10794431
88Large eyes (HP:0001090)2.09534191
89Limb dystonia (HP:0002451)2.09224780
90Amyotrophic lateral sclerosis (HP:0007354)2.08402238
91Abnormality of the labia minora (HP:0012880)2.07858238
92Action tremor (HP:0002345)2.07029462
93EEG with generalized epileptiform discharges (HP:0011198)2.06051228
94Genetic anticipation (HP:0003743)2.05953675
95Astrocytoma (HP:0009592)2.05729135
96Abnormality of the astrocytes (HP:0100707)2.05729135
97Hypsarrhythmia (HP:0002521)2.04627476
98Amblyopia (HP:0000646)2.03595968
99Tetraplegia (HP:0002445)2.01904937
100Absence seizures (HP:0002121)2.01127071
101Supraventricular tachycardia (HP:0004755)2.00763094
102Rhabdomyolysis (HP:0003201)2.00378539
103Abnormal mitochondria in muscle tissue (HP:0008316)1.99713223
104Hyperacusis (HP:0010780)1.98859704
105Spastic gait (HP:0002064)1.97218939
106Renal Fanconi syndrome (HP:0001994)1.96834310
107Abnormal social behavior (HP:0012433)1.96832002
108Impaired social interactions (HP:0000735)1.96832002
109Unsteady gait (HP:0002317)1.96650771
110Broad distal phalanx of finger (HP:0009836)1.96158446
111Narrow nasal bridge (HP:0000446)1.95928820
112Primary atrial arrhythmia (HP:0001692)1.95328198
113Supranuclear gaze palsy (HP:0000605)1.95275229
114Athetosis (HP:0002305)1.95054097
115Agitation (HP:0000713)1.94770347
116Oligomenorrhea (HP:0000876)1.94708310
117Abnormality of the calf musculature (HP:0001430)1.94671857
118Progressive microcephaly (HP:0000253)1.94286873
119Supraventricular arrhythmia (HP:0005115)1.93795060
120Opisthotonus (HP:0002179)1.93186242
121Hyperglycinemia (HP:0002154)1.92446657
122Calf muscle hypertrophy (HP:0008981)1.90689305
123Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.90065505
124Fetal akinesia sequence (HP:0001989)1.89948955
125Renal duplication (HP:0000075)1.89323353
126Atrial fibrillation (HP:0005110)1.88584689
127Cerebral hypomyelination (HP:0006808)1.87504351
128Generalized hypotonia (HP:0001290)1.87485168
129Papilledema (HP:0001085)1.87290184
130Reduced antithrombin III activity (HP:0001976)1.86760827
131CNS demyelination (HP:0007305)1.84874421
132Limb-girdle muscle atrophy (HP:0003797)1.84347864
133Centrally nucleated skeletal muscle fibers (HP:0003687)1.83377115
134Atrophy/Degeneration involving motor neurons (HP:0007373)1.83292710
135Lower limb muscle weakness (HP:0007340)1.83226950
136Facial cleft (HP:0002006)1.82017407
137Macrocytic anemia (HP:0001972)1.81175317
138EMG: myopathic abnormalities (HP:0003458)1.80555886
139Abnormality of the aortic arch (HP:0012303)1.80382012
140Abnormality of the umbilical cord (HP:0010881)1.80380919
141Colon cancer (HP:0003003)1.80235989
142Muscle hypertrophy of the lower extremities (HP:0008968)1.80077199
143Hypercortisolism (HP:0001578)1.78997221
144Bradykinesia (HP:0002067)1.77358550
145Dialeptic seizures (HP:0011146)1.77221361
146Myopathic facies (HP:0002058)1.77040577
147Optic disc pallor (HP:0000543)1.76654732
148Long toe (HP:0010511)1.76620059
149Acute necrotizing encephalopathy (HP:0006965)1.76516407
150Delusions (HP:0000746)1.75763707
151Prolonged QT interval (HP:0001657)1.75755627
152Myoglobinuria (HP:0002913)1.74694352
153Meningioma (HP:0002858)1.73779390
154Incomplete penetrance (HP:0003829)1.71995126
155Dicarboxylic aciduria (HP:0003215)1.71881932
156Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71881932
157Hepatocellular necrosis (HP:0001404)1.71745145
158Dysmetric saccades (HP:0000641)1.69506257
159Lethargy (HP:0001254)1.66282912
160Hand muscle atrophy (HP:0009130)1.66029432
161Methylmalonic aciduria (HP:0012120)1.62873145
162Postnatal microcephaly (HP:0005484)1.61439661
163Adducted thumb (HP:0001181)1.59778758
164Muscle fiber atrophy (HP:0100295)1.59127335
165Trismus (HP:0000211)1.57651836
166Overriding aorta (HP:0002623)1.56058340
167Cholelithiasis (HP:0001081)1.55852314
168Multiple enchondromatosis (HP:0005701)1.54428796
169Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.54419723
170Nemaline bodies (HP:0003798)1.54161117
171Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.53391224
172X-linked dominant inheritance (HP:0001423)1.50853126
173Delayed CNS myelination (HP:0002188)1.50050301
174Hypokinesia (HP:0002375)1.49187028
175Abnormality of cochlea (HP:0000375)1.48433765
176Spastic paraparesis (HP:0002313)1.47962303
177Annular pancreas (HP:0001734)1.47645823
178Calcaneovalgus deformity (HP:0001848)1.45638530
179Gout (HP:0001997)1.44173504
180Deformed tarsal bones (HP:0008119)1.41671410
181Upper limb amyotrophy (HP:0009129)1.40538062
182Distal upper limb amyotrophy (HP:0007149)1.40538062
183Patent foramen ovale (HP:0001655)1.40230375
184Birth length less than 3rd percentile (HP:0003561)1.40172167
185Abnormalities of placenta or umbilical cord (HP:0001194)1.40020393
186Occipital encephalocele (HP:0002085)1.39862268

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.65506703
2MARK13.52731002
3NTRK33.40640690
4NME23.38231154
5INSRR2.99876769
6MAP2K72.70476954
7PRPF4B2.63548459
8EPHA42.60214627
9MINK12.53131011
10MAP3K42.41858567
11NEK12.28794208
12MAP3K122.28770125
13PBK2.18260122
14DAPK12.13961813
15PHKG12.09493562
16PHKG22.09493562
17PRKD32.05727563
18CASK2.01778551
19DAPK22.01774944
20CDK191.83970148
21MAP3K91.79795109
22CDC71.77265807
23VRK11.73663868
24LIMK11.72739871
25PAK61.71491002
26NTRK21.68521988
27CSNK1G31.67120526
28SRPK11.66072263
29CCNB11.62867309
30KSR21.61030957
31CAMKK11.60446891
32ZAK1.55492197
33PIM21.52648224
34KDR1.51954363
35KSR11.51152824
36MAP4K21.51127434
37MAPK131.50486106
38PLK21.40121408
39LMTK21.38378386
40TRIB31.37407448
41EIF2AK11.36669618
42NME11.34598171
43TTK1.34532545
44CSNK1G21.34451566
45BRSK11.31278840
46LATS21.30290233
47PDK41.29126990
48PDK31.29126990
49TESK11.28795924
50MAP2K41.28693679
51PLK31.23850849
52CSNK1A1L1.23454785
53PINK11.21515103
54CSNK1G11.19679448
55PRKCG1.19020564
56MUSK1.15641486
57TNIK1.15127838
58SMG11.13283916
59UHMK11.13210626
60CDK51.11423373
61TSSK61.10675065
62SCYL21.10615298
63ABL21.10191421
64RPS6KA21.10041184
65PLK11.09446670
66CDK181.07048501
67MYLK1.05284121
68WEE11.04200401
69TRIM281.02210106
70PKN21.01530049
71CDK150.99926929
72CDK140.95737332
73NTRK10.94868355
74CHEK20.93870827
75SIK30.93824909
76OBSCN0.93277759
77ATR0.90810772
78CDK11A0.89360192
79CAMK10.88197924
80MAPKAPK50.87776598
81DAPK30.82368259
82CDC42BPA0.78487194
83PLK40.77993224
84SGK20.77771492
85ERBB30.75844023
86BRAF0.75501627
87AURKB0.73138233
88MAP3K70.72273562
89EEF2K0.71327446
90CAMK2G0.71096665
91SGK30.70669604
92AKT20.69309641
93CDK70.69072734
94TAOK10.68591895
95PRKCH0.67936769
96MARK20.67751286
97STK380.67077687
98CAMK40.66733546
99SGK4940.65637158
100SGK2230.65637158
101EIF2AK20.64918710
102CAMKK20.64651601
103LRRK20.64613815
104WNK30.64483061
105RPS6KA50.63127883
106EPHB20.62218043
107DYRK20.62125896
108GRK50.60846142
109PAK10.59473561
110ALK0.56660266
111ILK0.56522092
112ARAF0.55134481
113CAMK2B0.55029622
114AKT30.54595916
115PRKCI0.53246028
116PAK40.52867865
117IRAK30.51922017
118MAPKAPK30.51037450
119MAP3K20.50602946
120NUAK10.50582048
121CDK80.50558267
122BUB10.49685677
123STK160.49581811
124PDK20.49576024
125BCKDK0.49278889
126TESK20.47965420
127RPS6KB20.47676553
128PAK30.46271860
129MAP2K10.45639311
130RPS6KL10.45485644
131RPS6KC10.45485644
132TTN0.45402685
133MAP3K110.44388021
134TAOK20.44201822
135MAP3K10.44183837
136RET0.43935687
137CAMK2A0.43402904
138PTK2B0.43377962
139TAF10.43110734
140CSNK2A20.43062930
141CSNK2A10.42941381
142AURKA0.42425053
143PRKCZ0.42120223
144CHEK10.41591556
145PKN10.39476541
146RPS6KB10.38844841
147DYRK1A0.38620486
148MKNK20.38400431
149CAMK2D0.36814562
150MAP3K80.34983473

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.82038002
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.30438209
3Ribosome_Homo sapiens_hsa030102.89869160
4Nicotine addiction_Homo sapiens_hsa050332.56588844
5Olfactory transduction_Homo sapiens_hsa047402.46512945
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.43711373
7Circadian entrainment_Homo sapiens_hsa047132.42585155
8RNA polymerase_Homo sapiens_hsa030202.26104385
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21078291
10Long-term potentiation_Homo sapiens_hsa047202.20976542
11Sulfur relay system_Homo sapiens_hsa041222.14502399
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14167060
13GABAergic synapse_Homo sapiens_hsa047272.11855760
14Amphetamine addiction_Homo sapiens_hsa050312.04696599
15Fatty acid elongation_Homo sapiens_hsa000622.04323352
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.02724096
17Dopaminergic synapse_Homo sapiens_hsa047281.99780853
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94656273
19Pyrimidine metabolism_Homo sapiens_hsa002401.93193812
20Insulin secretion_Homo sapiens_hsa049111.91865760
21Morphine addiction_Homo sapiens_hsa050321.89286525
22Vitamin B6 metabolism_Homo sapiens_hsa007501.81977887
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78374633
24Cardiac muscle contraction_Homo sapiens_hsa042601.75736200
25Glutamatergic synapse_Homo sapiens_hsa047241.74042152
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73528369
27Cholinergic synapse_Homo sapiens_hsa047251.59760037
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59238115
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.56186063
30Folate biosynthesis_Homo sapiens_hsa007901.56091490
31Spliceosome_Homo sapiens_hsa030401.53550636
32Nucleotide excision repair_Homo sapiens_hsa034201.52185624
33Parkinsons disease_Homo sapiens_hsa050121.50041348
34Collecting duct acid secretion_Homo sapiens_hsa049661.49575250
35One carbon pool by folate_Homo sapiens_hsa006701.45716927
36Gap junction_Homo sapiens_hsa045401.44818571
37Oxytocin signaling pathway_Homo sapiens_hsa049211.43149094
38Non-homologous end-joining_Homo sapiens_hsa034501.41743751
39Vibrio cholerae infection_Homo sapiens_hsa051101.39415962
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38339918
41Homologous recombination_Homo sapiens_hsa034401.38309279
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36471984
43RNA transport_Homo sapiens_hsa030131.34879946
44Pentose phosphate pathway_Homo sapiens_hsa000301.34690117
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33881515
46Dilated cardiomyopathy_Homo sapiens_hsa054141.31928235
47Fanconi anemia pathway_Homo sapiens_hsa034601.28174511
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27501436
49Oocyte meiosis_Homo sapiens_hsa041141.26229924
50Gastric acid secretion_Homo sapiens_hsa049711.24629298
51Oxidative phosphorylation_Homo sapiens_hsa001901.24551601
52Cocaine addiction_Homo sapiens_hsa050301.21544296
53Arginine and proline metabolism_Homo sapiens_hsa003301.19788938
54Calcium signaling pathway_Homo sapiens_hsa040201.18639369
55Propanoate metabolism_Homo sapiens_hsa006401.17635876
56Long-term depression_Homo sapiens_hsa047301.16453595
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16440793
58Salivary secretion_Homo sapiens_hsa049701.15984248
59N-Glycan biosynthesis_Homo sapiens_hsa005101.15598922
60Glioma_Homo sapiens_hsa052141.13643144
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13211626
62Taste transduction_Homo sapiens_hsa047421.12096076
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08253491
64Protein export_Homo sapiens_hsa030601.07359048
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05824141
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.05273902
67Cell cycle_Homo sapiens_hsa041101.04475957
68GnRH signaling pathway_Homo sapiens_hsa049121.03475136
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01377824
70Glutathione metabolism_Homo sapiens_hsa004801.00959116
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00938354
72Serotonergic synapse_Homo sapiens_hsa047261.00556652
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99994757
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98530383
75Insulin signaling pathway_Homo sapiens_hsa049100.96619708
76Alzheimers disease_Homo sapiens_hsa050100.94902524
77Carbon metabolism_Homo sapiens_hsa012000.94899121
78Huntingtons disease_Homo sapiens_hsa050160.93959251
79Renin secretion_Homo sapiens_hsa049240.93833054
80Biosynthesis of amino acids_Homo sapiens_hsa012300.92467124
81Type II diabetes mellitus_Homo sapiens_hsa049300.90644576
82Fructose and mannose metabolism_Homo sapiens_hsa000510.90145814
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.89951175
84Estrogen signaling pathway_Homo sapiens_hsa049150.89222831
85Alcoholism_Homo sapiens_hsa050340.85850456
86Proteasome_Homo sapiens_hsa030500.85334636
87Melanogenesis_Homo sapiens_hsa049160.84341350
88cAMP signaling pathway_Homo sapiens_hsa040240.83926508
89RNA degradation_Homo sapiens_hsa030180.82598968
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81098766
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81000184
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80896199
93Glucagon signaling pathway_Homo sapiens_hsa049220.80724669
94Axon guidance_Homo sapiens_hsa043600.80414534
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80224479
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79961171
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.79870516
98Metabolic pathways_Homo sapiens_hsa011000.77951071
99ErbB signaling pathway_Homo sapiens_hsa040120.77526208
100Endometrial cancer_Homo sapiens_hsa052130.76977966
101Phenylalanine metabolism_Homo sapiens_hsa003600.76808005
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76478898
103Galactose metabolism_Homo sapiens_hsa000520.75221537
104Fatty acid metabolism_Homo sapiens_hsa012120.73949390
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.71803000
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68556131
107DNA replication_Homo sapiens_hsa030300.68110012
108Thyroid cancer_Homo sapiens_hsa052160.66792977
109Peroxisome_Homo sapiens_hsa041460.66510440
110mTOR signaling pathway_Homo sapiens_hsa041500.60967790
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60953426
112Arginine biosynthesis_Homo sapiens_hsa002200.60859461
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60728439
114beta-Alanine metabolism_Homo sapiens_hsa004100.58957453
115Non-small cell lung cancer_Homo sapiens_hsa052230.58804871
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58201898
117Tyrosine metabolism_Homo sapiens_hsa003500.57792753
118Butanoate metabolism_Homo sapiens_hsa006500.55188063
119Base excision repair_Homo sapiens_hsa034100.54753128
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53092330
121Pyruvate metabolism_Homo sapiens_hsa006200.53031814
122Selenocompound metabolism_Homo sapiens_hsa004500.52938855
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51620966
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50429298
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48852636
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48396887
127mRNA surveillance pathway_Homo sapiens_hsa030150.48317574
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46240125
129MAPK signaling pathway_Homo sapiens_hsa040100.45316895
130Basal transcription factors_Homo sapiens_hsa030220.43522917
131Purine metabolism_Homo sapiens_hsa002300.42573922
132Steroid biosynthesis_Homo sapiens_hsa001000.42070357
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41361369
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40031416
135Colorectal cancer_Homo sapiens_hsa052100.39035423
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37422204
137Mismatch repair_Homo sapiens_hsa034300.34467962
138Endocytosis_Homo sapiens_hsa041440.33539383
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.33452334
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.32901339
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32431373
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31434710
143HIF-1 signaling pathway_Homo sapiens_hsa040660.31352644
144Prion diseases_Homo sapiens_hsa050200.30593537
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30588495
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30169564
147Sulfur metabolism_Homo sapiens_hsa009200.29937636
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29920515
149Fatty acid degradation_Homo sapiens_hsa000710.29347902
150Hippo signaling pathway_Homo sapiens_hsa043900.27072494
151Phototransduction_Homo sapiens_hsa047440.23002768
152Basal cell carcinoma_Homo sapiens_hsa052170.21970915
153p53 signaling pathway_Homo sapiens_hsa041150.21145608
154Regulation of autophagy_Homo sapiens_hsa041400.18513774

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