ERICH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.09768120
2regulation of B cell receptor signaling pathway (GO:0050855)4.55452609
3positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.42656412
4positive regulation of B cell differentiation (GO:0045579)4.18451961
5DNA deamination (GO:0045006)4.11058294
6immunoglobulin mediated immune response (GO:0016064)4.01082248
7negative regulation of cell killing (GO:0031342)3.70022948
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.70022948
9regulation of mast cell activation (GO:0033003)3.66799624
10positive regulation of mast cell activation (GO:0033005)3.64554785
11negative T cell selection (GO:0043383)3.62907087
12negative thymic T cell selection (GO:0045060)3.59981457
13regulation of gamma-delta T cell activation (GO:0046643)3.51837210
14regulation of B cell differentiation (GO:0045577)3.51817471
15regulation of nuclear cell cycle DNA replication (GO:0033262)3.46363479
16lymphoid progenitor cell differentiation (GO:0002320)3.45710459
17positive regulation of mast cell activation involved in immune response (GO:0033008)3.41038572
18positive regulation of mast cell degranulation (GO:0043306)3.41038572
19B cell mediated immunity (GO:0019724)3.39382773
20negative regulation of T cell mediated immunity (GO:0002710)3.37418876
21regulation of mast cell activation involved in immune response (GO:0033006)3.35990288
22regulation of mast cell degranulation (GO:0043304)3.32438028
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31189606
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.31189606
25modulation by symbiont of host immune response (GO:0052553)3.31189606
26positive regulation by symbiont of host defense response (GO:0052509)3.31189606
27modulation by symbiont of host defense response (GO:0052031)3.31189606
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31189606
29regulation of gamma-delta T cell differentiation (GO:0045586)3.30599523
30positive thymic T cell selection (GO:0045059)3.30166026
31superoxide anion generation (GO:0042554)3.26649959
32ribosomal small subunit assembly (GO:0000028)3.24673426
33mast cell degranulation (GO:0043303)3.23388494
34mast cell activation involved in immune response (GO:0002279)3.23388494
35tRNA methylation (GO:0030488)3.22051516
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22048893
37cellular extravasation (GO:0045123)3.20970475
38positive regulation of granulocyte differentiation (GO:0030854)3.19320944
39T cell migration (GO:0072678)3.18946762
40DNA ligation (GO:0006266)3.17576697
41deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.15517829
42neutrophil activation (GO:0042119)3.15044426
43DNA damage response, detection of DNA damage (GO:0042769)3.10012140
44myeloid cell activation involved in immune response (GO:0002275)3.09584848
45B cell receptor signaling pathway (GO:0050853)3.06601258
46negative regulation of execution phase of apoptosis (GO:1900118)3.05300688
47purine deoxyribonucleotide catabolic process (GO:0009155)3.02942057
48leukocyte degranulation (GO:0043299)3.02900085
49microglial cell activation (GO:0001774)3.02889056
50negative regulation of interleukin-12 production (GO:0032695)3.01501228
51defense response to protozoan (GO:0042832)2.96607990
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.95424453
53centriole assembly (GO:0098534)2.94548306
54response to protozoan (GO:0001562)2.92914296
55proteasome assembly (GO:0043248)2.92628668
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91879491
57CENP-A containing nucleosome assembly (GO:0034080)2.90706280
58purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.90538213
59positive T cell selection (GO:0043368)2.88092213
60regulation of tolerance induction (GO:0002643)2.88058115
61deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.86789060
62regulation of myeloid leukocyte mediated immunity (GO:0002886)2.85532924
63termination of RNA polymerase III transcription (GO:0006386)2.84974337
64transcription elongation from RNA polymerase III promoter (GO:0006385)2.84974337
65regulation of T cell tolerance induction (GO:0002664)2.84768846
66regulation of alpha-beta T cell proliferation (GO:0046640)2.84545518
67regulation of T cell cytokine production (GO:0002724)2.82046629
68pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.80687702
69chromatin remodeling at centromere (GO:0031055)2.79200695
70ribosomal small subunit biogenesis (GO:0042274)2.78011590
71positive regulation of antigen processing and presentation (GO:0002579)2.77340683
72protein complex biogenesis (GO:0070271)2.76813004
73response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.76463141
74response to host immune response (GO:0052572)2.76463141
75negative regulation of lymphocyte mediated immunity (GO:0002707)2.74175476
76meiotic chromosome segregation (GO:0045132)2.73874944
77tRNA modification (GO:0006400)2.73698399
78macrophage activation involved in immune response (GO:0002281)2.73620618
79telomere maintenance via semi-conservative replication (GO:0032201)2.72281951
80GPI anchor biosynthetic process (GO:0006506)2.71686015
81purinergic nucleotide receptor signaling pathway (GO:0035590)2.71291906
82positive regulation of alpha-beta T cell proliferation (GO:0046641)2.70749823
83respiratory chain complex IV assembly (GO:0008535)2.70592437
84deoxyribonucleotide catabolic process (GO:0009264)2.70034078
85transcription elongation from RNA polymerase I promoter (GO:0006362)2.69519521
86pseudouridine synthesis (GO:0001522)2.68433366
87granulocyte activation (GO:0036230)2.67912884
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.66936425
89T cell selection (GO:0045058)2.66614660
90regulation of antigen processing and presentation (GO:0002577)2.66558477
91neutrophil mediated immunity (GO:0002446)2.65781062
92antigen processing and presentation of endogenous antigen (GO:0019883)2.65486825
93leukocyte aggregation (GO:0070486)2.65272050
94respiratory burst (GO:0045730)2.65267545
95mesenchymal cell differentiation involved in kidney development (GO:0072161)2.63301651
96mesenchymal cell differentiation involved in renal system development (GO:2001012)2.63301651
97polyketide metabolic process (GO:0030638)2.62227776
98doxorubicin metabolic process (GO:0044598)2.62227776
99daunorubicin metabolic process (GO:0044597)2.62227776
100activated T cell proliferation (GO:0050798)2.61032764
101termination of RNA polymerase I transcription (GO:0006363)2.60790008
102mitochondrial respiratory chain complex I assembly (GO:0032981)2.60761604
103NADH dehydrogenase complex assembly (GO:0010257)2.60761604
104mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.60761604
105response to interleukin-15 (GO:0070672)2.60238256
106pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.59714746
107regulation of MHC class II biosynthetic process (GO:0045346)2.59655801
108mitochondrial respiratory chain complex assembly (GO:0033108)2.59263300
109regulation of RIG-I signaling pathway (GO:0039535)2.57513554
110kinetochore organization (GO:0051383)2.56819640
111rRNA modification (GO:0000154)2.55851265
112regulation of pigment cell differentiation (GO:0050932)2.55607366
113RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54889755
114tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54889755
115DNA catabolic process, exonucleolytic (GO:0000738)2.54363332
116detection of other organism (GO:0098543)2.54114647
117positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.54001475
118regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.53829223
119regulation of hypersensitivity (GO:0002883)2.53370666
120positive regulation of natural killer cell differentiation (GO:0032825)2.52332735
121cytochrome complex assembly (GO:0017004)2.51612487
122regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.51368161
123G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.50672842
124positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.50399428
125telomere maintenance via recombination (GO:0000722)2.50170401
126regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.50169134
127detection of bacterium (GO:0016045)2.50117114
128pyrimidine nucleotide catabolic process (GO:0006244)2.49552812
129negative regulation of leukocyte mediated immunity (GO:0002704)2.49272042
130deoxyribose phosphate catabolic process (GO:0046386)2.49104257
131transcription from RNA polymerase I promoter (GO:0006360)2.49045802
132positive regulation of DNA recombination (GO:0045911)2.48709713
133regulation of B cell apoptotic process (GO:0002902)2.48638811
134antigen processing and presentation via MHC class Ib (GO:0002475)2.47788846
135rRNA methylation (GO:0031167)2.47373227
136tRNA processing (GO:0008033)2.47060176
137platelet dense granule organization (GO:0060155)2.46513984
138kinetochore assembly (GO:0051382)2.46356617
139positive regulation of B cell activation (GO:0050871)2.45885043
140autophagic vacuole fusion (GO:0000046)2.44544336
141positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.43616579
142positive regulation of developmental pigmentation (GO:0048087)2.43241502
143regulation of granulocyte differentiation (GO:0030852)2.43185982
144histone H2B ubiquitination (GO:0033523)2.43089363
145negative regulation of DNA-dependent DNA replication (GO:2000104)2.42926796
146Arp2/3 complex-mediated actin nucleation (GO:0034314)2.42520601
147RNA methylation (GO:0001510)2.41789035
148interferon-gamma production (GO:0032609)2.40706299
149positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.40614352
150regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.38074462
151regulation of double-strand break repair via homologous recombination (GO:0010569)2.37431558
152ribosomal large subunit biogenesis (GO:0042273)2.36609322
153mast cell activation (GO:0045576)2.36168607
154ribonucleoprotein complex biogenesis (GO:0022613)2.34543638
155dendritic cell chemotaxis (GO:0002407)2.34465623
156telomere maintenance via telomere lengthening (GO:0010833)2.34176085
157negative regulation of mast cell activation (GO:0033004)2.31805273
158natural killer cell activation involved in immune response (GO:0002323)2.31675995
159GPI anchor metabolic process (GO:0006505)2.31553612
160response to peptidoglycan (GO:0032494)2.31028090
161maturation of 5.8S rRNA (GO:0000460)2.30465907
162protein K6-linked ubiquitination (GO:0085020)2.30302667
163RNA-dependent DNA replication (GO:0006278)2.29722032
164replication fork processing (GO:0031297)2.29701409
165DNA strand renaturation (GO:0000733)2.28027014
166negative regulation of telomere maintenance (GO:0032205)2.27996173
167centriole replication (GO:0007099)2.27651502
168response to UV-B (GO:0010224)2.26699953
169mannosylation (GO:0097502)2.26621238
170response to X-ray (GO:0010165)2.26477511
171N-acetylneuraminate metabolic process (GO:0006054)2.26389820
172response to interferon-beta (GO:0035456)2.26373425
173maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.26100751
174cellular response to interferon-beta (GO:0035458)2.25684497
175DNA replication checkpoint (GO:0000076)2.25580947
176DNA-dependent DNA replication (GO:0006261)2.25353618
177mitotic recombination (GO:0006312)2.24311468
178positive regulation of defense response to virus by host (GO:0002230)2.23502015
179pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.23259472
180cell differentiation involved in metanephros development (GO:0072202)2.22850486
181keratinocyte development (GO:0003334)2.22814792
182CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.21722999
183maturation of SSU-rRNA (GO:0030490)2.21034618
184deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.20216804
185DNA replication-independent nucleosome assembly (GO:0006336)2.20214932
186DNA replication-independent nucleosome organization (GO:0034724)2.20214932
187neutrophil activation involved in immune response (GO:0002283)2.19011939
188positive regulation of protein homodimerization activity (GO:0090073)2.18138798
189viral mRNA export from host cell nucleus (GO:0046784)2.18134189
190developmental pigmentation (GO:0048066)2.18031928
191transcription initiation from RNA polymerase I promoter (GO:0006361)2.17443518
192ribosome biogenesis (GO:0042254)2.16180948
1937-methylguanosine RNA capping (GO:0009452)2.15919969

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.34507760
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.82538430
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.66193122
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17135933
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.02854044
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.87315099
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87252902
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.80626882
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.59162862
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.57585448
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.44332102
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.40577900
13IRF1_19129219_ChIP-ChIP_H3396_Human2.40242147
14RUNX_20019798_ChIP-Seq_JUKART_Human2.36213933
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.35465140
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31547012
17MYB_26560356_Chip-Seq_TH2_Human2.28183862
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.27286541
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18149840
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17688695
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.15725933
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.15466930
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10510484
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03407487
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.00663840
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.98720407
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98696898
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.94272543
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92534630
30* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91831228
31ELK1_19687146_ChIP-ChIP_HELA_Human1.88761376
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84731167
33MYB_26560356_Chip-Seq_TH1_Human1.83307921
34VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.78596809
35GATA3_27048872_Chip-Seq_THYMUS_Human1.78192035
36SPI1_23127762_ChIP-Seq_K562_Human1.78053985
37GATA3_26560356_Chip-Seq_TH2_Human1.78048522
38* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74411286
39CIITA_25753668_ChIP-Seq_RAJI_Human1.72069001
40* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71185941
41VDR_24763502_ChIP-Seq_THP-1_Human1.69978192
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69161358
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66324204
44UTX_26944678_Chip-Seq_JUKART_Human1.65588399
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65384143
46VDR_21846776_ChIP-Seq_THP-1_Human1.63816374
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62753385
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62737145
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.62023447
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61672578
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.60384223
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60231152
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60034086
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59096538
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57263472
56VDR_23849224_ChIP-Seq_CD4+_Human1.56639200
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.56439818
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.56439818
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.56439818
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54294466
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54119249
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53637084
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.52311900
64MAF_26560356_Chip-Seq_TH1_Human1.50264737
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45243521
66ZNF274_21170338_ChIP-Seq_K562_Hela1.42511093
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42041067
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.40396924
69MAF_26560356_Chip-Seq_TH2_Human1.39470146
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39355823
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38058295
72* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37479840
73FOXP3_21729870_ChIP-Seq_TREG_Human1.36689665
74* RUNX1_22412390_ChIP-Seq_EML_Mouse1.35506523
75BCL6_27268052_Chip-Seq_Bcells_Human1.34353453
76SPI1_23547873_ChIP-Seq_NB4_Human1.32866079
77IGF1R_20145208_ChIP-Seq_DFB_Human1.32545315
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31893259
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31153871
80RNF2_27304074_Chip-Seq_NSC_Mouse1.30862681
81MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29876265
82VDR_22108803_ChIP-Seq_LS180_Human1.29644808
83MYC_22102868_ChIP-Seq_BL_Human1.29027711
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28762857
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28465815
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27894145
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.27775589
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27186895
89ETS1_20019798_ChIP-Seq_JURKAT_Human1.26716072
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25935071
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24669294
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23412164
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.23384011
94NMYC_18555785_Chip-Seq_ESCs_Mouse1.22685860
95P300_27268052_Chip-Seq_Bcells_Human1.19593359
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19392033
97RUNX1_27457419_Chip-Seq_LIVER_Mouse1.19380233
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18295725
99SCL_19346495_ChIP-Seq_HPC-7_Human1.17926760
100TTF2_22483619_ChIP-Seq_HELA_Human1.17065346
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16680892
102P300_18555785_Chip-Seq_ESCs_Mouse1.15463627
103* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15364159
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14998866
105ELF1_20517297_ChIP-Seq_JURKAT_Human1.13388277
106POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12946204
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.11766367
108RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11754408
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11695448
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11103459
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10990272
112ZFX_18555785_Chip-Seq_ESCs_Mouse1.10775544
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09446194
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.09345554
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09128657
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09084730
117VDR_24787735_ChIP-Seq_THP-1_Human1.08373959
118P53_22387025_ChIP-Seq_ESCs_Mouse1.08318617
119MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07633755
120GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07461013
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05946122
122STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04991749
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04756764
124SMRT_27268052_Chip-Seq_Bcells_Human1.04755925
125STAT1_20625510_ChIP-Seq_HELA_Human1.04585030
126MYC_18940864_ChIP-ChIP_HL60_Human1.04353306
127* SPI1_20517297_ChIP-Seq_HL60_Human1.04126447
128KLF4_18555785_Chip-Seq_ESCs_Mouse1.04043310
129IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04003083
130OCT4_18555785_Chip-Seq_ESCs_Mouse1.02097381
131SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01080833
132RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99827833
133ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99558310
134SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98643748
135SOX2_18555785_Chip-Seq_ESCs_Mouse0.97134156
136GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96994467
137CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96950284
138DCP1A_22483619_ChIP-Seq_HELA_Human0.96264166
139ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95442346
140FUS_26573619_Chip-Seq_HEK293_Human0.95178320
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95012696
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94686953
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.94315229
144BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93740692
145EWS_26573619_Chip-Seq_HEK293_Human0.93038473
146CMYC_18555785_Chip-Seq_ESCs_Mouse0.92590482
147CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92566553
148* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92529338
149GBX2_23144817_ChIP-Seq_PC3_Human0.92458782
150GATA3_21878914_ChIP-Seq_MCF-7_Human0.91897290
151TP53_22573176_ChIP-Seq_HFKS_Human0.91311082
152MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91223824
153TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91142095
154NANOG_20526341_ChIP-Seq_ESCs_Human0.91051628
155CTCF_18555785_Chip-Seq_ESCs_Mouse0.90828346
156ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88381764
157PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87990172
158GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87945092
159TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87567028
160RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86616852

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.25579408
2MP0004381_abnormal_hair_follicle3.38884094
3MP0003136_yellow_coat_color3.21041179
4MP0005075_abnormal_melanosome_morpholog2.90768598
5MP0008058_abnormal_DNA_repair2.90290453
6MP0001188_hyperpigmentation2.74950110
7MP0005464_abnormal_platelet_physiology2.53964324
8MP0001835_abnormal_antigen_presentation2.41997684
9MP0008057_abnormal_DNA_replication2.39120707
10MP0003303_peritoneal_inflammation2.30278408
11MP0002148_abnormal_hypersensitivity_rea2.18217433
12MP0000015_abnormal_ear_pigmentation2.16986456
13MP0005671_abnormal_response_to2.15877421
14MP0002277_abnormal_respiratory_mucosa2.12937188
15MP0005409_darkened_coat_color2.10619395
16MP0005174_abnormal_tail_pigmentation2.01842634
17MP0010094_abnormal_chromosome_stability2.00004158
18MP0009785_altered_susceptibility_to1.98351447
19MP0000372_irregular_coat_pigmentation1.92492385
20MP0003693_abnormal_embryo_hatching1.92348252
21MP0003941_abnormal_skin_development1.85656996
22MP0009379_abnormal_foot_pigmentation1.85439581
23MP0003724_increased_susceptibility_to1.81908205
24MP0003763_abnormal_thymus_physiology1.81526215
25MP0003828_pulmonary_edema1.72928229
26MP0000569_abnormal_digit_pigmentation1.71293133
27MP0003786_premature_aging1.70687308
28MP0005171_absent_coat_pigmentation1.67782602
29MP0003806_abnormal_nucleotide_metabolis1.63894657
30MP0001545_abnormal_hematopoietic_system1.61271062
31MP0005397_hematopoietic_system_phenotyp1.61271062
32MP0009333_abnormal_splenocyte_physiolog1.58008003
33MP0009278_abnormal_bone_marrow1.57998507
34MP0002138_abnormal_hepatobiliary_system1.57769584
35MP0001986_abnormal_taste_sensitivity1.55618527
36MP0003718_maternal_effect1.55466855
37MP0005000_abnormal_immune_tolerance1.51858773
38MP0005379_endocrine/exocrine_gland_phen1.51854761
39MP0002132_abnormal_respiratory_system1.51022886
40MP0002396_abnormal_hematopoietic_system1.49880018
41MP0005310_abnormal_salivary_gland1.47141542
42MP0002095_abnormal_skin_pigmentation1.46556857
43MP0003111_abnormal_nucleus_morphology1.46507510
44MP0003172_abnormal_lysosome_physiology1.45022989
45MP0001845_abnormal_inflammatory_respons1.44749958
46MP0009764_decreased_sensitivity_to1.43306816
47MP0003787_abnormal_imprinting1.43082527
48MP0005025_abnormal_response_to1.41056366
49MP0005410_abnormal_fertilization1.40295734
50MP0002419_abnormal_innate_immunity1.40152469
51MP0002452_abnormal_antigen_presenting1.37848380
52MP0005451_abnormal_body_composition1.36803855
53MP0001873_stomach_inflammation1.34309562
54MP0008932_abnormal_embryonic_tissue1.32750093
55MP0001533_abnormal_skeleton_physiology1.31368155
56MP0001819_abnormal_immune_cell1.31362488
57MP0002420_abnormal_adaptive_immunity1.30541128
58MP0002723_abnormal_immune_serum1.30456841
59MP0005387_immune_system_phenotype1.30261143
60MP0001790_abnormal_immune_system1.30261143
61MP0002938_white_spotting1.30113609
62MP0002009_preneoplasia1.28199259
63MP0002102_abnormal_ear_morphology1.28193091
64MP0001800_abnormal_humoral_immune1.25359861
65MP0003880_abnormal_central_pattern1.25328328
66MP0008007_abnormal_cellular_replicative1.25045837
67MP0000566_synostosis1.24928662
68MP0002405_respiratory_system_inflammati1.24159393
69MP0003077_abnormal_cell_cycle1.23396471
70MP0008469_abnormal_protein_level1.23155768
71MP0005084_abnormal_gallbladder_morpholo1.21794831
72MP0000465_gastrointestinal_hemorrhage1.21472520
73MP0003878_abnormal_ear_physiology1.21365738
74MP0005377_hearing/vestibular/ear_phenot1.21365738
75MP0004782_abnormal_surfactant_physiolog1.21190456
76MP0000490_abnormal_crypts_of1.19630041
77MP0002254_reproductive_system_inflammat1.17199175
78MP0003938_abnormal_ear_development1.15821928
79MP0002638_abnormal_pupillary_reflex1.15579457
80MP0000049_abnormal_middle_ear1.14720945
81MP0009697_abnormal_copulation1.11891482
82MP0003436_decreased_susceptibility_to1.07931532
83MP0008995_early_reproductive_senescence1.07792267
84MP0002398_abnormal_bone_marrow1.07415482
85MP0002163_abnormal_gland_morphology1.04807636
86MP0003866_abnormal_defecation1.03261421
87MP0000716_abnormal_immune_system1.00094798
88MP0000613_abnormal_salivary_gland0.97347851
89MP0009765_abnormal_xenobiotic_induced0.97257763
90MP0002249_abnormal_larynx_morphology0.96022148
91MP0002177_abnormal_outer_ear0.95699086
92MP0001853_heart_inflammation0.95652745
93MP0003121_genomic_imprinting0.95205002
94MP0006036_abnormal_mitochondrial_physio0.94704965
95MP0001968_abnormal_touch/_nociception0.94470203
96MP0002751_abnormal_autonomic_nervous0.94416739
97MP0004947_skin_inflammation0.93783361
98MP0008872_abnormal_physiological_respon0.93730388
99MP0000026_abnormal_inner_ear0.93027671
100MP0000689_abnormal_spleen_morphology0.92915291
101MP0006082_CNS_inflammation0.91765841
102MP0001186_pigmentation_phenotype0.91601711
103MP0001919_abnormal_reproductive_system0.90475676
104MP0001348_abnormal_lacrimal_gland0.89136238
105MP0004957_abnormal_blastocyst_morpholog0.89123282
106MP0002722_abnormal_immune_system0.88545078
107MP0010386_abnormal_urinary_bladder0.88291821
108MP0005408_hypopigmentation0.87319352
109MP0009763_increased_sensitivity_to0.85451735
110MP0002429_abnormal_blood_cell0.82766385
111MP0002735_abnormal_chemical_nociception0.81835305
112MP0002006_tumorigenesis0.81525809
113MP0000685_abnormal_immune_system0.80203668
114MP0004808_abnormal_hematopoietic_stem0.79271116
115MP0005646_abnormal_pituitary_gland0.79216829
116MP0001286_abnormal_eye_development0.79068525
117MP0002019_abnormal_tumor_incidence0.78046617
118MP0002075_abnormal_coat/hair_pigmentati0.77329948
119MP0003315_abnormal_perineum_morphology0.77306841
120MP0000858_altered_metastatic_potential0.76713817
121MP0003638_abnormal_response/metabolism_0.76017195
122MP0006035_abnormal_mitochondrial_morpho0.75684632
123MP0001663_abnormal_digestive_system0.75090758
124MP0000703_abnormal_thymus_morphology0.75090201
125MP0005389_reproductive_system_phenotype0.74847832
126MP0000631_abnormal_neuroendocrine_gland0.73389250
127MP0004133_heterotaxia0.72802122
128MP0000681_abnormal_thyroid_gland0.71852104
129MP0008877_abnormal_DNA_methylation0.71788547
130MP0001851_eye_inflammation0.71419734
131MP0010155_abnormal_intestine_physiology0.70924414
132MP0001764_abnormal_homeostasis0.70417127
133MP0008260_abnormal_autophagy0.70238120
134MP0005253_abnormal_eye_physiology0.69781133
135MP0001119_abnormal_female_reproductive0.69665867
136MP0008961_abnormal_basal_metabolism0.69119119
137MP0001963_abnormal_hearing_physiology0.69016481
138MP0003183_abnormal_peptide_metabolism0.68053302
139MP0008873_increased_physiological_sensi0.67172606
140MP0003890_abnormal_embryonic-extraembry0.66372423
141MP0004142_abnormal_muscle_tone0.65455885
142MP0002876_abnormal_thyroid_physiology0.65413098
143MP0002653_abnormal_ependyma_morphology0.65189422
144MP0004742_abnormal_vestibular_system0.64336027
145MP0003195_calcinosis0.64125273
146MP0000230_abnormal_systemic_arterial0.63498396
147MP0003698_abnormal_male_reproductive0.62806674
148MP0001905_abnormal_dopamine_level0.61826749
149MP0002693_abnormal_pancreas_physiology0.61244308
150MP0005319_abnormal_enzyme/_coenzyme0.58127920
151MP0001929_abnormal_gametogenesis0.58120768

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.38635584
2Chromsome breakage (HP:0040012)4.89887242
3Duplicated collecting system (HP:0000081)3.92162766
4Abnormal delayed hypersensitivity skin test (HP:0002963)3.76049246
5Abnormality of the renal collecting system (HP:0004742)3.66255904
6Recurrent cutaneous fungal infections (HP:0011370)3.65050214
7Chronic mucocutaneous candidiasis (HP:0002728)3.65050214
8Panhypogammaglobulinemia (HP:0003139)3.62299748
9Recurrent fungal infections (HP:0002841)3.62145161
10Reticulocytopenia (HP:0001896)3.56868148
11Agammaglobulinemia (HP:0004432)3.39851472
12Prolonged bleeding time (HP:0003010)3.36349741
13Encephalitis (HP:0002383)3.26391565
14Abnormality of DNA repair (HP:0003254)3.01945795
15Recurrent skin infections (HP:0001581)2.99724691
16Abnormality of T cells (HP:0002843)2.97104227
17Absent/shortened dynein arms (HP:0200106)2.96564868
18Dynein arm defect of respiratory motile cilia (HP:0012255)2.96564868
19IgG deficiency (HP:0004315)2.91201591
20Abnormality of the preputium (HP:0100587)2.90912823
21Renal cortical cysts (HP:0000803)2.90005102
22Gastrointestinal infarctions (HP:0005244)2.89985705
23Asplenia (HP:0001746)2.88893971
24Type I transferrin isoform profile (HP:0003642)2.87738803
25Meckel diverticulum (HP:0002245)2.83303351
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.81159116
27Abnormality of T cell number (HP:0011839)2.80740402
28Abnormality of macrophages (HP:0004311)2.78962834
29Pustule (HP:0200039)2.75552510
30Abnormality of the ileum (HP:0001549)2.73089665
31T lymphocytopenia (HP:0005403)2.72712457
32Abnormality of T cell physiology (HP:0011840)2.71107051
33Autoimmune hemolytic anemia (HP:0001890)2.67044417
34Osteomalacia (HP:0002749)2.64936477
35Aplasia/Hypoplasia of the spleen (HP:0010451)2.62655143
36Nephroblastoma (Wilms tumor) (HP:0002667)2.59403767
373-Methylglutaconic aciduria (HP:0003535)2.59177274
38Clubbing of toes (HP:0100760)2.58855812
39Epistaxis (HP:0000421)2.58695462
40Abnormality of B cell number (HP:0010975)2.55631976
41Vasculitis (HP:0002633)2.54222228
42Recurrent viral infections (HP:0004429)2.54221497
43Abnormal ciliary motility (HP:0012262)2.50283925
44Recurrent abscess formation (HP:0002722)2.49732860
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.49365656
46Gingival bleeding (HP:0000225)2.48105127
47Ectopic kidney (HP:0000086)2.47124231
48Leukocytosis (HP:0001974)2.44860972
49Keratoconjunctivitis (HP:0001096)2.44444864
50Recurrent gram-negative bacterial infections (HP:0005420)2.41630723
51Mitochondrial inheritance (HP:0001427)2.41138639
52Pulmonary infiltrates (HP:0002113)2.40160418
53Embryonal renal neoplasm (HP:0011794)2.39942095
54Abnormality of chromosome stability (HP:0003220)2.38361855
55Thrombocytosis (HP:0001894)2.36665152
56Autoimmune thrombocytopenia (HP:0001973)2.36052276
57Polydipsia (HP:0001959)2.35703176
58Abnormal drinking behavior (HP:0030082)2.35703176
59Duplication of thumb phalanx (HP:0009942)2.35319705
60Patchy hypopigmentation of hair (HP:0011365)2.32666096
61Increased IgM level (HP:0003496)2.32482433
62Chronic obstructive pulmonary disease (HP:0006510)2.31387428
63Obstructive lung disease (HP:0006536)2.31387428
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31043989
65Abnormal respiratory epithelium morphology (HP:0012253)2.30563553
66Abnormal respiratory motile cilium morphology (HP:0005938)2.30563553
67Reduced antithrombin III activity (HP:0001976)2.30134043
68Acute necrotizing encephalopathy (HP:0006965)2.28258237
69Upper limb muscle weakness (HP:0003484)2.24887222
70Optic neuritis (HP:0100653)2.24202130
71Retrobulbar optic neuritis (HP:0100654)2.24202130
72Septo-optic dysplasia (HP:0100842)2.22563197
73True hermaphroditism (HP:0010459)2.20005755
74White forelock (HP:0002211)2.18964816
75Keratoconjunctivitis sicca (HP:0001097)2.17693976
76Birth length less than 3rd percentile (HP:0003561)2.16327979
77Type 2 muscle fiber atrophy (HP:0003554)2.14458654
78Abnormal rod and cone electroretinograms (HP:0008323)2.14166639
79Anorexia (HP:0002039)2.13999369
80Mediastinal lymphadenopathy (HP:0100721)2.11437244
81Molar tooth sign on MRI (HP:0002419)2.11150066
82Abnormality of midbrain morphology (HP:0002418)2.11150066
83Exertional dyspnea (HP:0002875)2.11072415
84Renal Fanconi syndrome (HP:0001994)2.10339144
85Intestinal atresia (HP:0011100)2.10016079
86Bone marrow hypocellularity (HP:0005528)2.09628152
87Pancreatic cysts (HP:0001737)2.09527605
88Chest pain (HP:0100749)2.09212891
89Hemoptysis (HP:0002105)2.08907641
90Hypochromic anemia (HP:0001931)2.08753494
91Combined immunodeficiency (HP:0005387)2.08207082
92Elevated erythrocyte sedimentation rate (HP:0003565)2.08020301
93Myositis (HP:0100614)2.07756421
94Abnormal mitochondria in muscle tissue (HP:0008316)2.07753683
95Hepatocellular necrosis (HP:0001404)2.07330480
96Prostate neoplasm (HP:0100787)2.07182100
97Abnormality of cells of the erythroid lineage (HP:0012130)2.07111090
98Aplastic anemia (HP:0001915)2.03953003
99Hypochromic microcytic anemia (HP:0004840)2.03200150
100Increased CSF lactate (HP:0002490)2.03062005
101Hypoplasia of the fovea (HP:0007750)2.01816715
102Aplasia/Hypoplasia of the fovea (HP:0008060)2.01816715
103Hypertensive crisis (HP:0100735)2.01009020
104Aplasia/Hypoplasia of the thymus (HP:0010515)1.99846092
105Inflammation of the large intestine (HP:0002037)1.99816480
106Supernumerary spleens (HP:0009799)1.99396014
107Pancytopenia (HP:0001876)1.98754648
108Duodenal stenosis (HP:0100867)1.97663191
109Small intestinal stenosis (HP:0012848)1.97663191
110Stomatitis (HP:0010280)1.97082562
111Triphalangeal thumb (HP:0001199)1.96893818
112Episodic fever (HP:0001954)1.96427008
113Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.95145048
114Pallor (HP:0000980)1.95128796
115Gastrointestinal inflammation (HP:0004386)1.95074510
116Absent radius (HP:0003974)1.94996543
117Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94630057
118Neutropenia (HP:0001875)1.94510858
119Attenuation of retinal blood vessels (HP:0007843)1.93873193
120Nephronophthisis (HP:0000090)1.93564702
121Arterial thrombosis (HP:0004420)1.92668981
122Abnormal biliary tract physiology (HP:0012439)1.92414730
123Bile duct proliferation (HP:0001408)1.92414730
124Adrenal hypoplasia (HP:0000835)1.91447897
125Respiratory difficulties (HP:0002880)1.91394508
126Urticaria (HP:0001025)1.90804383
127Alveolar cell carcinoma (HP:0006519)1.89795447
128Myelodysplasia (HP:0002863)1.89769175
129Abnormal respiratory motile cilium physiology (HP:0012261)1.88973495
130IgM deficiency (HP:0002850)1.88291809
131Abnormal protein glycosylation (HP:0012346)1.88271318
132Abnormal glycosylation (HP:0012345)1.88271318
133Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88271318
134Abnormal protein N-linked glycosylation (HP:0012347)1.88271318
135Aplasia involving forearm bones (HP:0009822)1.88264657
136Absent forearm bone (HP:0003953)1.88264657
137Stomach cancer (HP:0012126)1.88259041
138Severe combined immunodeficiency (HP:0004430)1.87711516
139Acute hepatic failure (HP:0006554)1.87121319
140Absent thumb (HP:0009777)1.86548734
141Tetany (HP:0001281)1.86506350
142Eczematoid dermatitis (HP:0000976)1.86360330
143Meningitis (HP:0001287)1.86134826
144Abnormal number of erythroid precursors (HP:0012131)1.85439655
145Petechiae (HP:0000967)1.84824418
146Muscle fiber atrophy (HP:0100295)1.84211593
147Neoplasm of the tracheobronchial system (HP:0100552)1.83443747
148Abnormality of renal resorption (HP:0011038)1.83395208
149Polyuria (HP:0000103)1.82942844
150Recurrent bacterial skin infections (HP:0005406)1.82816739
151Orchitis (HP:0100796)1.81984435
152Severe visual impairment (HP:0001141)1.81832262
153Lymphopenia (HP:0001888)1.81485034
154Granulocytopenia (HP:0001913)1.81294248
155Gangrene (HP:0100758)1.81148151
156Progressive macrocephaly (HP:0004481)1.81003968
157Supernumerary bones of the axial skeleton (HP:0009144)1.80640397
158Cleft eyelid (HP:0000625)1.80545691
159Congenital stationary night blindness (HP:0007642)1.79969197
160Hypergonadotropic hypogonadism (HP:0000815)1.79857755
161Abnormal lung lobation (HP:0002101)1.78765513
162Pancreatic fibrosis (HP:0100732)1.78148242
163Abnormality of the columella (HP:0009929)1.77444995
164Dry hair (HP:0011359)1.77155340
165Abnormality of eosinophils (HP:0001879)1.75858710
166Abnormality of the prostate (HP:0008775)1.74228811
167Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74218614
168Eosinophilia (HP:0001880)1.74209968
169Oligohydramnios (HP:0001562)1.73518481
170Lymphoma (HP:0002665)1.73232002
171Premature graying of hair (HP:0002216)1.69781005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.70835994
2TXK2.71966199
3CASK2.67908782
4IRAK32.66581177
5IRAK42.65567323
6MAP3K142.51821370
7FES2.48344932
8GRK62.42228422
9ZAK2.15057582
10TNIK2.06696722
11MKNK22.05994113
12SRPK12.01452019
13EIF2AK21.95110971
14MKNK11.89926800
15BMPR1B1.89213683
16GRK11.88842799
17TRIM281.88382924
18YES11.85607652
19VRK11.83083810
20ADRBK21.83006031
21MUSK1.81838034
22MAP4K21.77641194
23BLK1.75158241
24OXSR11.70582618
25CLK11.64782158
26WNK41.63446245
27PIM21.51174262
28NME21.49748983
29BCKDK1.48705430
30NEK61.44527372
31KDR1.43521291
32IKBKB1.41800269
33NUAK11.41088425
34NLK1.38388429
35TEC1.38013113
36ITK1.36721857
37TLK11.36111308
38PBK1.35755235
39NME11.35455610
40GRK71.34103609
41MST41.29047274
42BMPR21.23524571
43IKBKE1.23036814
44PLK41.22365832
45PRPF4B1.22130918
46MARK31.19735407
47FGR1.18507506
48VRK21.13115637
49FRK1.10882821
50KIT1.09107895
51MAP2K31.08878017
52MAP4K11.08374295
53CDK31.03657411
54CHEK20.98428882
55CDK190.97863227
56BTK0.97473130
57PRKCQ0.96682201
58CDK70.95621114
59TESK20.95513926
60STK390.93841061
61TNK20.93635077
62MAP3K110.92873634
63WEE10.92239452
64EIF2AK30.89830580
65PTK2B0.88560580
66IRAK10.88200064
67PIK3CG0.87890226
68PIM10.87315995
69CDK80.81586076
70TIE10.81340257
71DYRK20.80676537
72CHUK0.79908459
73TAOK30.79345182
74LYN0.79270182
75EPHA30.79176455
76ACVR1B0.78131989
77ATR0.75861952
78BUB10.75373220
79DYRK1B0.75235115
80EPHA20.71677358
81MAPK150.71305012
82TTK0.69831051
83RPS6KA50.68559442
84JAK20.68463194
85STK40.67326145
86DYRK30.61914322
87PLK10.61427180
88MAP2K70.61397621
89LCK0.61351739
90SYK0.59837617
91JAK10.58714580
92MAPK130.56442017
93CDC70.55874632
94JAK30.55507071
95MATK0.54570451
96IRAK20.53980789
97SIK30.53567754
98EIF2AK10.53073337
99FLT30.50882646
100ERBB30.50612745
101PKN10.49761433
102BCR0.48403927
103SIK20.48022135
104AURKB0.47865614
105MAPKAPK50.47795524
106TRPM70.47551399
107CSK0.47306488
108CSNK2A10.46805793
109MARK20.46735527
110PDK10.46431867
111PRKD20.46331819
112HCK0.45256213
113BRSK20.44858226
114LRRK20.44277109
115CDK40.43980810
116TGFBR10.43833700
117CSF1R0.42948613
118ZAP700.42255383
119STK100.42078476
120BMX0.39713653
121DAPK20.38567328
122ATM0.38171414
123INSRR0.38053331
124MAP2K20.37820235
125TYK20.36862392
126RIPK40.36510387
127AKT30.36397152
128PLK30.35660392
129CHEK10.35252496
130MAP2K60.35067439
131RPS6KA60.33924105
132TBK10.33840159
133PASK0.33514513
134MAP3K10.33169406
135EGFR0.33050078
136TAOK10.32828148
137ADRBK10.32359449
138BRD40.31526795
139FYN0.31270295
140GRK50.31239777
141MAPK70.30896255
142CSNK2A20.30002385
143CAMK10.29753422
144MAP3K70.29581457
145IGF1R0.29012237
146MAPK30.26028445
147RPS6KC10.24807580

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.83021176
2Ribosome_Homo sapiens_hsa030102.81381195
3DNA replication_Homo sapiens_hsa030302.67340579
4Homologous recombination_Homo sapiens_hsa034402.62846727
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.58799243
6RNA polymerase_Homo sapiens_hsa030202.44210679
7Mismatch repair_Homo sapiens_hsa034302.40543566
8Staphylococcus aureus infection_Homo sapiens_hsa051502.15233181
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07096398
10Non-homologous end-joining_Homo sapiens_hsa034502.02921888
11Base excision repair_Homo sapiens_hsa034101.94152291
12Nucleotide excision repair_Homo sapiens_hsa034201.87729030
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.83808792
14Pyrimidine metabolism_Homo sapiens_hsa002401.83693677
15Basal transcription factors_Homo sapiens_hsa030221.75359545
16Graft-versus-host disease_Homo sapiens_hsa053321.75053905
17Proteasome_Homo sapiens_hsa030501.74847106
18Spliceosome_Homo sapiens_hsa030401.73011743
19Protein export_Homo sapiens_hsa030601.71731852
20Allograft rejection_Homo sapiens_hsa053301.70278877
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69483884
22B cell receptor signaling pathway_Homo sapiens_hsa046621.59361018
23Primary immunodeficiency_Homo sapiens_hsa053401.58122763
24RNA degradation_Homo sapiens_hsa030181.55521127
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53540080
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53415741
27Autoimmune thyroid disease_Homo sapiens_hsa053201.48477508
28Phototransduction_Homo sapiens_hsa047441.45450144
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.37321277
30Arachidonic acid metabolism_Homo sapiens_hsa005901.33308023
31Measles_Homo sapiens_hsa051621.32520418
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24585403
33Hematopoietic cell lineage_Homo sapiens_hsa046401.24121025
34Herpes simplex infection_Homo sapiens_hsa051681.23197247
35Asthma_Homo sapiens_hsa053101.22532920
36One carbon pool by folate_Homo sapiens_hsa006701.19352500
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16318152
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12606478
39Purine metabolism_Homo sapiens_hsa002301.12243224
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11746273
41Cell cycle_Homo sapiens_hsa041101.10091193
42Platelet activation_Homo sapiens_hsa046111.07122554
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06477586
44Other glycan degradation_Homo sapiens_hsa005111.04987458
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03847739
46Sphingolipid metabolism_Homo sapiens_hsa006001.02768760
47Leishmaniasis_Homo sapiens_hsa051400.98562885
48Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95903823
49Viral myocarditis_Homo sapiens_hsa054160.94498171
50Rheumatoid arthritis_Homo sapiens_hsa053230.93076909
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92631419
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92071755
53p53 signaling pathway_Homo sapiens_hsa041150.91714429
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90349472
55RNA transport_Homo sapiens_hsa030130.90067613
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85904106
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81784470
58Ether lipid metabolism_Homo sapiens_hsa005650.81230368
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.80406572
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79941248
61Malaria_Homo sapiens_hsa051440.79622768
62Oxidative phosphorylation_Homo sapiens_hsa001900.79547010
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76305588
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.76243396
65Collecting duct acid secretion_Homo sapiens_hsa049660.75496831
66Epstein-Barr virus infection_Homo sapiens_hsa051690.75371178
67mRNA surveillance pathway_Homo sapiens_hsa030150.74888121
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73529618
69Linoleic acid metabolism_Homo sapiens_hsa005910.70240121
70Olfactory transduction_Homo sapiens_hsa047400.70084632
71Legionellosis_Homo sapiens_hsa051340.69203153
72Type I diabetes mellitus_Homo sapiens_hsa049400.68388192
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.65826097
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65750503
75Influenza A_Homo sapiens_hsa051640.65681008
76Pertussis_Homo sapiens_hsa051330.65017599
77Huntingtons disease_Homo sapiens_hsa050160.63985930
78Acute myeloid leukemia_Homo sapiens_hsa052210.61664651
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57699963
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57418623
81Parkinsons disease_Homo sapiens_hsa050120.55583736
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53391247
83Apoptosis_Homo sapiens_hsa042100.53304641
84Peroxisome_Homo sapiens_hsa041460.52535194
85Hepatitis B_Homo sapiens_hsa051610.52025315
86Antigen processing and presentation_Homo sapiens_hsa046120.51521203
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49745383
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47869114
89African trypanosomiasis_Homo sapiens_hsa051430.47089351
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45202299
91Regulation of autophagy_Homo sapiens_hsa041400.44996189
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44737189
93TNF signaling pathway_Homo sapiens_hsa046680.43409288
94Tuberculosis_Homo sapiens_hsa051520.42410151
95Osteoclast differentiation_Homo sapiens_hsa043800.41469348
96Salmonella infection_Homo sapiens_hsa051320.40378950
97Systemic lupus erythematosus_Homo sapiens_hsa053220.39463226
98T cell receptor signaling pathway_Homo sapiens_hsa046600.38725598
99Fatty acid elongation_Homo sapiens_hsa000620.37519970
100Chemokine signaling pathway_Homo sapiens_hsa040620.37181984
101Notch signaling pathway_Homo sapiens_hsa043300.36498168
102Phagosome_Homo sapiens_hsa041450.35674014
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35136170
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34282877
105Nitrogen metabolism_Homo sapiens_hsa009100.34056447
106Melanoma_Homo sapiens_hsa052180.33573834
107HTLV-I infection_Homo sapiens_hsa051660.33391856
108Hepatitis C_Homo sapiens_hsa051600.32734716
109Small cell lung cancer_Homo sapiens_hsa052220.31979921
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31570585
111Alzheimers disease_Homo sapiens_hsa050100.31037440
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30623336
113Shigellosis_Homo sapiens_hsa051310.30451129
114Toxoplasmosis_Homo sapiens_hsa051450.27775284
115Lysosome_Homo sapiens_hsa041420.25718005
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21526018
117Cardiac muscle contraction_Homo sapiens_hsa042600.19617285
118Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16229630

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