ERICH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.92969115
2response to pheromone (GO:0019236)9.80741063
3plasma membrane fusion (GO:0045026)9.61201293
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.60909199
5spermatid development (GO:0007286)9.22779387
6reproduction (GO:0000003)9.21687190
7regulation of cilium movement (GO:0003352)8.43011483
8male meiosis (GO:0007140)7.31712965
9single fertilization (GO:0007338)7.31193925
10piRNA metabolic process (GO:0034587)7.28734103
11sperm capacitation (GO:0048240)7.23770721
12synaptonemal complex organization (GO:0070193)7.13800177
13synaptonemal complex assembly (GO:0007130)6.92061051
14negative regulation of inclusion body assembly (GO:0090084)6.42628502
15ventricular system development (GO:0021591)6.37262920
16spermatogenesis (GO:0007283)6.13531195
17fertilization (GO:0009566)6.12717010
18male gamete generation (GO:0048232)6.11180639
19rRNA methylation (GO:0031167)6.07908835
20organic cation transport (GO:0015695)5.66444664
21spermatid nucleus differentiation (GO:0007289)5.63106633
22gamete generation (GO:0007276)5.62075448
23regulation of inclusion body assembly (GO:0090083)5.43619509
24microtubule depolymerization (GO:0007019)5.33596841
25cellular ketone body metabolic process (GO:0046950)5.15715634
26phosphatidylethanolamine biosynthetic process (GO:0006646)5.15381183
27rRNA modification (GO:0000154)5.15159996
28germ cell development (GO:0007281)5.12500686
29male meiosis I (GO:0007141)5.08604774
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.06004911
31calcium ion-dependent exocytosis (GO:0017156)4.95154211
32microtubule severing (GO:0051013)4.94609968
33regulation of microtubule-based movement (GO:0060632)4.93665690
34regulation of centriole replication (GO:0046599)4.88322206
35cell recognition (GO:0008037)4.85377312
36protein targeting to Golgi (GO:0000042)4.85213758
37regulation of Rab GTPase activity (GO:0032313)4.83163056
38positive regulation of Rab GTPase activity (GO:0032851)4.83163056
39chromosome organization involved in meiosis (GO:0070192)4.74152800
40axoneme assembly (GO:0035082)4.70991900
41establishment of protein localization to Golgi (GO:0072600)4.69372266
42phosphatidylethanolamine metabolic process (GO:0046337)4.67753652
43DNA methylation involved in gamete generation (GO:0043046)4.57394559
44left/right pattern formation (GO:0060972)4.54589212
45ketone body metabolic process (GO:1902224)4.52250460
46nucleoside diphosphate phosphorylation (GO:0006165)4.48214488
47GTP biosynthetic process (GO:0006183)4.47541752
48multicellular organismal reproductive process (GO:0048609)4.42648748
49retrograde transport, vesicle recycling within Golgi (GO:0000301)4.40263961
50regulation of transcription involved in cell fate commitment (GO:0060850)4.39213562
51coenzyme catabolic process (GO:0009109)4.30107928
52meiotic nuclear division (GO:0007126)4.26600771
53intraciliary transport (GO:0042073)4.19002666
54seminiferous tubule development (GO:0072520)4.14489691
55glycerol ether metabolic process (GO:0006662)4.14138092
56sexual reproduction (GO:0019953)4.07860131
57chromatin silencing (GO:0006342)4.07615092
58glomerular epithelial cell development (GO:0072310)4.07469249
59meiosis I (GO:0007127)4.04691719
60UTP biosynthetic process (GO:0006228)3.99230673
61single strand break repair (GO:0000012)3.91454842
62protein polyglutamylation (GO:0018095)3.89659099
63cilium organization (GO:0044782)3.86733634
64chromosome condensation (GO:0030261)3.86631727
65ether metabolic process (GO:0018904)3.82700654
66glomerular visceral epithelial cell development (GO:0072015)3.79190785
67centriole assembly (GO:0098534)3.78875140
68meiotic cell cycle (GO:0051321)3.73953809
69cilium assembly (GO:0042384)3.70478496
70chaperone-mediated protein complex assembly (GO:0051131)3.65733745
71DNA packaging (GO:0006323)3.65400112
72UTP metabolic process (GO:0046051)3.64757473
73genitalia morphogenesis (GO:0035112)3.59790111
74monoubiquitinated protein deubiquitination (GO:0035520)3.54231342
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.54173251
76microtubule-based movement (GO:0007018)3.52455047
77multicellular organismal development (GO:0007275)3.49125058
78protein localization to cilium (GO:0061512)3.45083365
79cellular component assembly involved in morphogenesis (GO:0010927)3.43169560
80protein localization to Golgi apparatus (GO:0034067)3.40029579
81protein refolding (GO:0042026)3.39630851
82protein K11-linked deubiquitination (GO:0035871)3.39474191
83histone H3-K9 demethylation (GO:0033169)3.37480592
84cerebral cortex neuron differentiation (GO:0021895)3.30756714
85peptidyl-threonine dephosphorylation (GO:0035970)3.24946302
86cilium morphogenesis (GO:0060271)3.24359831
87nucleosome disassembly (GO:0006337)3.19570660
88protein-DNA complex disassembly (GO:0032986)3.19570660
89left/right axis specification (GO:0070986)3.18774932
90regulation of phosphoprotein phosphatase activity (GO:0043666)3.16993753
91centriole replication (GO:0007099)3.11932527
92muscle organ morphogenesis (GO:0048644)3.10422565
93cranial nerve morphogenesis (GO:0021602)3.07978945
94guanosine-containing compound biosynthetic process (GO:1901070)3.06731281
95CTP biosynthetic process (GO:0006241)3.05283750
96CTP metabolic process (GO:0046036)3.05283750
97negative regulation of Rho protein signal transduction (GO:0035024)3.04741941
98cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.04228544
99RNA destabilization (GO:0050779)2.99541742
100musculoskeletal movement (GO:0050881)2.97920769
101multicellular organismal movement (GO:0050879)2.97920769
102male sex determination (GO:0030238)2.94707541
103response to acidic pH (GO:0010447)2.94422411
104detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.92463184
105polyamine biosynthetic process (GO:0006596)2.91100332
106protein depolymerization (GO:0051261)2.90962973
107histone exchange (GO:0043486)2.90764651
108glycolytic process (GO:0006096)2.85658284
109cellular response to pH (GO:0071467)2.83767533
110negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.80765701
111pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.79339492
112pattern specification involved in kidney development (GO:0061004)2.78906664
113regulation of spindle checkpoint (GO:0090231)2.78467262
114pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.75909650
115meiotic cell cycle process (GO:1903046)2.74938504
116synapsis (GO:0007129)2.73835465
117microtubule polymerization or depolymerization (GO:0031109)2.73207304
118carnitine transport (GO:0015879)2.71558733
119amino-acid betaine transport (GO:0015838)2.71558733
120nucleus organization (GO:0006997)2.69875696
121positive regulation of macrophage activation (GO:0043032)2.68876102
122alditol metabolic process (GO:0019400)2.68793174
123sequestering of actin monomers (GO:0042989)2.68563342
124negative regulation of organelle assembly (GO:1902116)2.64410260
125pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.60977791
126carnitine transmembrane transport (GO:1902603)2.56860698
127lactate metabolic process (GO:0006089)2.52878900
128gene silencing by RNA (GO:0031047)2.49923901
129sperm motility (GO:0030317)13.0768733
130cilium or flagellum-dependent cell motility (GO:0001539)12.7690133
131fusion of sperm to egg plasma membrane (GO:0007342)12.6351048
132cell wall macromolecule catabolic process (GO:0016998)12.3276023
133cell wall macromolecule metabolic process (GO:0044036)12.3276023
134axonemal dynein complex assembly (GO:0070286)12.2314817
135epithelial cilium movement (GO:0003351)11.8030823
136acrosome assembly (GO:0001675)11.2116079
137sperm-egg recognition (GO:0035036)11.1208868
138cilium movement (GO:0003341)10.8852192
139acrosome reaction (GO:0007340)10.8209709
140multicellular organism reproduction (GO:0032504)10.6849492
141motile cilium assembly (GO:0044458)10.3163766
142binding of sperm to zona pellucida (GO:0007339)10.1873998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.20282429
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.51807310
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.50137127
4EZH2_22144423_ChIP-Seq_EOC_Human4.32219009
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.45762536
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.21959689
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.87037275
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.82152615
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.58408296
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.40556374
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.32110137
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.23800274
13ERA_21632823_ChIP-Seq_H3396_Human2.17926914
14VDR_22108803_ChIP-Seq_LS180_Human2.17900386
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.10690962
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08572223
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08130165
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07104089
19ZNF274_21170338_ChIP-Seq_K562_Hela2.03893334
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.96354830
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95608160
22NANOG_20526341_ChIP-Seq_ESCs_Human1.95132565
23CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.94069842
24RAC3_21632823_ChIP-Seq_H3396_Human1.93602325
25AUTS2_25519132_ChIP-Seq_293T-REX_Human1.91029227
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89663149
27KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.89642742
28FUS_26573619_Chip-Seq_HEK293_Human1.89095853
29EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.85668681
30VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.84753136
31ELF1_20517297_ChIP-Seq_JURKAT_Human1.84365818
32ER_23166858_ChIP-Seq_MCF-7_Human1.84135246
33MYC_19829295_ChIP-Seq_ESCs_Human1.81135727
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.79378329
35RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.77672531
36RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.75774627
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70554642
38STAT1_17558387_ChIP-Seq_HELA_Human1.66834142
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64997467
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.64857824
41SMAD4_21741376_ChIP-Seq_EPCs_Human1.63745804
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.63077871
43CTCF_27219007_Chip-Seq_Bcells_Human1.61550144
44KAP1_22055183_ChIP-Seq_ESCs_Mouse1.60176233
45DROSHA_22980978_ChIP-Seq_HELA_Human1.59362064
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.57585221
47HNFA_21074721_ChIP-Seq_CACO-2_Human1.56351121
48OCT4_20526341_ChIP-Seq_ESCs_Human1.55193759
49E2F1_20622854_ChIP-Seq_HELA_Human1.54889244
50MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.54871599
51TAF2_19829295_ChIP-Seq_ESCs_Human1.54487601
52KDM2B_26808549_Chip-Seq_REH_Human1.53640677
53GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53322198
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53157442
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.52195059
56SOX2_22085726_ChIP-Seq_NPCs_Mouse1.52136459
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52012495
58CBP_20019798_ChIP-Seq_JUKART_Human1.52012495
59RBPJ_21746931_ChIP-Seq_IB4_Human1.50785442
60CBX2_22325352_ChIP-Seq_293T-Rex_Human1.50107845
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.50053384
62CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.49585044
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.48897194
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48813264
65CTCF_20526341_ChIP-Seq_ESCs_Human1.48086366
66ETV1_20927104_ChIP-Seq_GIST48_Human1.46137420
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.45376039
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44655485
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.44239167
70BCL6_27268052_Chip-Seq_Bcells_Human1.43861244
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.43661384
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.43458426
73SMC4_20622854_ChIP-Seq_HELA_Human1.43091847
74GATA3_21867929_ChIP-Seq_CD8_Mouse1.41691436
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41467794
76PHF8_20622853_ChIP-Seq_HELA_Human1.40133906
77BCOR_27268052_Chip-Seq_Bcells_Human1.39895682
78AR_25329375_ChIP-Seq_VCAP_Human1.39654920
79PHF8_20622854_ChIP-Seq_HELA_Human1.39404630
80FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39004359
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.38517241
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36467981
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35764455
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35747905
85TBL1_22424771_ChIP-Seq_293T_Human1.35369081
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.33389720
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33109056
88TP63_22573176_ChIP-Seq_HFKS_Human1.32899879
89P300_19829295_ChIP-Seq_ESCs_Human1.32199014
90SMAD3_21741376_ChIP-Seq_ESCs_Human1.32139191
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30672209
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30672209
93RNF2_27304074_Chip-Seq_NSC_Mouse1.27864132
94LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.27808708
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.27668168
96P300_27268052_Chip-Seq_Bcells_Human1.27603452
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26464705
98REST_21632747_ChIP-Seq_MESCs_Mouse1.26315083
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25637064
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25566054
101PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.24883369
102HOXB7_26014856_ChIP-Seq_BT474_Human1.23004774
103P68_20966046_ChIP-Seq_HELA_Human1.22594374
104GATA6_21074721_ChIP-Seq_CACO-2_Human1.22294367
105GATA3_21867929_ChIP-Seq_TH1_Mouse1.22010739
106NFYA_21822215_ChIP-Seq_K562_Human1.21920611
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21577529
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.21449579
109P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.21197777
110FOXH1_21741376_ChIP-Seq_EPCs_Human1.20760547
111NCOR_22424771_ChIP-Seq_293T_Human1.20490035
112P53_22387025_ChIP-Seq_ESCs_Mouse1.20005321
113OCT4_18555785_Chip-Seq_ESCs_Mouse1.19007390
114P53_21459846_ChIP-Seq_SAOS-2_Human1.18152006
115RUNX2_22187159_ChIP-Seq_PCA_Human1.17407406
116CEBPB_22108803_ChIP-Seq_LS180_Human1.17298409
117CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16178975
118SMAD4_21741376_ChIP-Seq_HESCs_Human1.15859306
119GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.15678476
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.13927532
121NANOG_19829295_ChIP-Seq_ESCs_Human1.13704846
122SOX2_19829295_ChIP-Seq_ESCs_Human1.13704846
123P300_18555785_Chip-Seq_ESCs_Mouse1.11914487
124TP53_18474530_ChIP-ChIP_U2OS_Human1.11656509
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11486119
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10939863
127RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10900448
128GF1_26923725_Chip-Seq_HPCs_Mouse1.10786006
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10724877
130E2F1_17053090_ChIP-ChIP_MCF-7_Human1.09609213
131SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08376485
132KLF4_18555785_Chip-Seq_ESCs_Mouse1.07710452
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07305323
134FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06784600
135ERG_20517297_ChIP-Seq_VCAP_Human1.06694112
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06561255
137EZH2_27294783_Chip-Seq_NPCs_Mouse1.06209897
138SMRT_27268052_Chip-Seq_Bcells_Human1.05971737
139EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03971728
140EZH2_27294783_Chip-Seq_ESCs_Mouse1.03698925
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03509833
142OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03323081
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03249733
144RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03150411
145MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03021103
146SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02862805
147OCT1_27270436_Chip-Seq_PROSTATE_Human1.02602165
148EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02395799
149RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01520957
150ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00536555
151NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00165169
152STAT3_18555785_Chip-Seq_ESCs_Mouse0.99859240
153SPI1_26923725_Chip-Seq_HPCs_Mouse0.98863821
154ESET_19884257_ChIP-Seq_ESCs_Mouse0.98293606
155SOX2_18555785_Chip-Seq_ESCs_Mouse0.97949188
156GF1B_26923725_Chip-Seq_HPCs_Mouse0.95988581
157SOX9_26525672_Chip-Seq_HEART_Mouse0.94075730
158PU1_27457419_Chip-Seq_LIVER_Mouse0.93657289
159TAF15_26573619_Chip-Seq_HEK293_Human0.93026213
160PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92560662
161CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91327127
162CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91326194
163NFYB_21822215_ChIP-Seq_K562_Human0.90631932
164CTCF_18555785_Chip-Seq_ESCs_Mouse0.89952732
165E2F1_18555785_Chip-Seq_ESCs_Mouse0.89615600
166SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87868741
167RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87867705
168MYC_27129775_Chip-Seq_CORNEA_Mouse0.87124226
169ZFX_18555785_Chip-Seq_ESCs_Mouse0.86610006
170YY1_22570637_ChIP-Seq_MALME-3M_Human0.85141392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08770053
2MP0001929_abnormal_gametogenesis5.53458383
3MP0008877_abnormal_DNA_methylation3.95736883
4MP0002653_abnormal_ependyma_morphology3.79048125
5MP0002210_abnormal_sex_determination3.54840340
6MP0002161_abnormal_fertility/fecundity3.29180827
7MP0001145_abnormal_male_reproductive2.98760293
8MP0000566_synostosis2.92855291
9MP0001348_abnormal_lacrimal_gland2.87943189
10MP0000678_abnormal_parathyroid_gland2.67473386
11MP0000653_abnormal_sex_gland2.58395991
12MP0005623_abnormal_meninges_morphology2.57990284
13MP0003718_maternal_effect2.43586647
14MP0001485_abnormal_pinna_reflex2.14088187
15MP0005410_abnormal_fertilization15.6023896
16MP0005670_abnormal_white_adipose1.99231444
17MP0002282_abnormal_trachea_morphology1.94965523
18MP0002160_abnormal_reproductive_system1.80909619
19MP0002249_abnormal_larynx_morphology1.72633035
20MP0002735_abnormal_chemical_nociception1.70358844
21MP0001486_abnormal_startle_reflex1.67308302
22MP0005423_abnormal_somatic_nervous1.64602802
23MP0005379_endocrine/exocrine_gland_phen1.57626940
24MP0009053_abnormal_anal_canal1.57162488
25MP0002234_abnormal_pharynx_morphology1.37820817
26MP0002822_catalepsy1.34601858
27MP0000049_abnormal_middle_ear1.29680584
28MP0009046_muscle_twitch1.27681606
29MP0001765_abnormal_ion_homeostasis1.27581824
30MP0003646_muscle_fatigue1.20785541
31MP0001963_abnormal_hearing_physiology1.20658197
32MP0002138_abnormal_hepatobiliary_system1.16508801
33MP0008058_abnormal_DNA_repair1.16311017
34MP0000026_abnormal_inner_ear1.15437524
35MP0005395_other_phenotype1.11301061
36MP0005083_abnormal_biliary_tract1.07095988
37MP0004233_abnormal_muscle_weight1.06918310
38MP0009697_abnormal_copulation1.06021165
39MP0005389_reproductive_system_phenotype1.01701991
40MP0001984_abnormal_olfaction0.98884209
41MP0005647_abnormal_sex_gland0.98165516
42MP0000681_abnormal_thyroid_gland0.97960677
43MP0005248_abnormal_Harderian_gland0.97293462
44MP0002733_abnormal_thermal_nociception0.95031407
45MP0008789_abnormal_olfactory_epithelium0.93588321
46MP0004859_abnormal_synaptic_plasticity0.93232636
47MP0003011_delayed_dark_adaptation0.91614985
48MP0003115_abnormal_respiratory_system0.89913710
49MP0002229_neurodegeneration0.88450819
50MP0008995_early_reproductive_senescence0.88149116
51MP0004133_heterotaxia0.87922105
52MP0003119_abnormal_digestive_system0.85919842
53MP0008057_abnormal_DNA_replication0.83795200
54MP0002127_abnormal_cardiovascular_syste0.82321761
55MP0004957_abnormal_blastocyst_morpholog0.81210635
56MP0005365_abnormal_bile_salt0.80794825
57MP0001970_abnormal_pain_threshold0.80513906
58MP0004085_abnormal_heartbeat0.80002747
59MP0000955_abnormal_spinal_cord0.79724637
60MP0002272_abnormal_nervous_system0.78815009
61MP0001293_anophthalmia0.78278882
62MP0004484_altered_response_of0.77301798
63MP0003936_abnormal_reproductive_system0.77206789
64MP0004510_myositis0.77114399
65MP0002067_abnormal_sensory_capabilities0.76729647
66MP0001299_abnormal_eye_distance/0.76569598
67MP0009745_abnormal_behavioral_response0.72367196
68MP0005408_hypopigmentation0.71909603
69MP0002132_abnormal_respiratory_system0.71790821
70MP0002734_abnormal_mechanical_nocicepti0.71634465
71MP0005394_taste/olfaction_phenotype0.71341718
72MP0005499_abnormal_olfactory_system0.71341718
73MP0005310_abnormal_salivary_gland0.70907850
74MP0001879_abnormal_lymphatic_vessel0.69681092
75MP0001666_abnormal_nutrient_absorption0.67662928
76MP0002572_abnormal_emotion/affect_behav0.67386242
77MP0002928_abnormal_bile_duct0.66904457
78MP0005636_abnormal_mineral_homeostasis0.66850756
79MP0003693_abnormal_embryo_hatching0.64936428
80MP0006292_abnormal_olfactory_placode0.64669106
81MP0001545_abnormal_hematopoietic_system0.64610787
82MP0005397_hematopoietic_system_phenotyp0.64610787
83MP0003077_abnormal_cell_cycle0.64193649
84MP0002557_abnormal_social/conspecific_i0.64055425
85MP0008004_abnormal_stomach_pH0.59956561
86MP0003137_abnormal_impulse_conducting0.59784325
87MP0000516_abnormal_urinary_system0.58969441
88MP0005367_renal/urinary_system_phenotyp0.58969441
89MP0001905_abnormal_dopamine_level0.58850559
90MP0000749_muscle_degeneration0.58655385
91MP0001324_abnormal_eye_pigmentation0.57886323
92MP0003942_abnormal_urinary_system0.57590908
93MP0000534_abnormal_ureter_morphology0.56445955
94MP0000470_abnormal_stomach_morphology0.55967262
95MP0002102_abnormal_ear_morphology0.55432823
96MP0003879_abnormal_hair_cell0.54664910
97MP0003878_abnormal_ear_physiology0.54429032
98MP0005377_hearing/vestibular/ear_phenot0.54429032
99MP0005085_abnormal_gallbladder_physiolo0.53331184
100MP0005253_abnormal_eye_physiology0.52927796
101MP0004019_abnormal_vitamin_homeostasis0.52825071
102MP0000537_abnormal_urethra_morphology0.52245901
103MP0003283_abnormal_digestive_organ0.50620668
104MP0005391_vision/eye_phenotype0.50262341
105MP0000569_abnormal_digit_pigmentation0.49668820
106MP0009780_abnormal_chondrocyte_physiolo0.49566020
107MP0010094_abnormal_chromosome_stability0.48448453
108MP0005388_respiratory_system_phenotype0.48351157
109MP0002133_abnormal_respiratory_system0.48351157
110MP0005551_abnormal_eye_electrophysiolog0.47835157
111MP0001270_distended_abdomen0.47088205
112MP0003136_yellow_coat_color0.46143546
113MP0003787_abnormal_imprinting0.45189828
114MP0003950_abnormal_plasma_membrane0.43857850
115MP0003861_abnormal_nervous_system0.43139226
116MP0000358_abnormal_cell_content/0.43121295
117MP0005666_abnormal_adipose_tissue0.41893660
118MP0002736_abnormal_nociception_after0.40168009
119MP0002092_abnormal_eye_morphology0.39610621
120MP0009250_abnormal_appendicular_skeleto0.38946304
121MP0003699_abnormal_female_reproductive0.38806161
122MP0003786_premature_aging0.36898694
123MP0002152_abnormal_brain_morphology0.35194779
124MP0004808_abnormal_hematopoietic_stem0.34847091
125MP0001119_abnormal_female_reproductive0.34471604
126MP0005646_abnormal_pituitary_gland0.33962720
127MP0008875_abnormal_xenobiotic_pharmacok0.33276139
128MP0006072_abnormal_retinal_apoptosis0.31604700
129MP0008007_abnormal_cellular_replicative0.31547095
130MP0005195_abnormal_posterior_eye0.30675556
131MP0001849_ear_inflammation0.30419870
132MP0004036_abnormal_muscle_relaxation0.30212458
133MP0009115_abnormal_fat_cell0.28603555
134MP0001958_emphysema0.28182192
135MP0004782_abnormal_surfactant_physiolog0.26937795
136MP0004742_abnormal_vestibular_system0.26848349
137MP0002295_abnormal_pulmonary_circulatio0.26564073
138MP0002084_abnormal_developmental_patter0.25859163
139MP0000778_abnormal_nervous_system0.25764537
140MP0001177_atelectasis0.24805190
141MP0000462_abnormal_digestive_system0.24491115
142MP0002971_abnormal_brown_adipose0.24321550
143MP0001727_abnormal_embryo_implantation0.24297311
144MP0003633_abnormal_nervous_system0.23714450
145MP0003634_abnormal_glial_cell0.23220954
146MP0003948_abnormal_gas_homeostasis0.22567630
147MP0000432_abnormal_head_morphology0.22038773
148MP0002697_abnormal_eye_size0.21931214
149MP0001764_abnormal_homeostasis0.21906946
150MP0002405_respiratory_system_inflammati0.20924552
151MP0002909_abnormal_adrenal_gland0.20254880
152MP0002116_abnormal_craniofacial_bone0.19578974
153MP0002109_abnormal_limb_morphology0.19527780
154MP0001919_abnormal_reproductive_system0.19227568
155MP0000631_abnormal_neuroendocrine_gland0.19219110
156MP0004811_abnormal_neuron_physiology0.18606399
157MP0006036_abnormal_mitochondrial_physio0.17885893
158MP0002752_abnormal_somatic_nervous0.17047380
159MP0003631_nervous_system_phenotype0.16686760
160MP0003329_amyloid_beta_deposits0.15908447
161MP0002169_no_abnormal_phenotype0.15650795
162MP0002873_normal_phenotype0.15255571
163MP0001968_abnormal_touch/_nociception0.15030574

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.71460495
2Abnormal respiratory motile cilium morphology (HP:0005938)9.71460495
3Abnormal ciliary motility (HP:0012262)9.43917866
4Rhinitis (HP:0012384)8.61533996
5Chronic bronchitis (HP:0004469)7.53362876
6Severe visual impairment (HP:0001141)6.71076853
7Nasal polyposis (HP:0100582)6.24015090
8Infertility (HP:0000789)6.09246515
9Bronchiectasis (HP:0002110)5.23703286
10Abnormality of the nasal mucosa (HP:0000433)5.23515933
11Attenuation of retinal blood vessels (HP:0007843)4.86554806
12Abnormal rod and cone electroretinograms (HP:0008323)4.79748185
13Bony spicule pigmentary retinopathy (HP:0007737)4.75274983
14Bronchitis (HP:0012387)4.55440409
15Nephronophthisis (HP:0000090)4.31280415
16Male infertility (HP:0003251)3.70378960
17Recurrent sinusitis (HP:0011108)3.55830005
18Aplasia/Hypoplasia of the earlobes (HP:0009906)3.50145608
19Resting tremor (HP:0002322)3.47473623
20Abnormality of the renal medulla (HP:0100957)3.40881078
21Potter facies (HP:0002009)3.36131465
22Facial shape deformation (HP:0011334)3.36131465
23Hyperventilation (HP:0002883)3.31498624
24Hypoplastic ischia (HP:0003175)3.26374403
25Recurrent otitis media (HP:0000403)3.19956863
26Tubulointerstitial nephritis (HP:0001970)3.01032483
27Abnormality of macular pigmentation (HP:0008002)3.00418395
28Hyperkalemia (HP:0002153)2.92878046
29Enlarged epiphyses (HP:0010580)2.91376292
30Abnormality of the ischium (HP:0003174)2.90472886
31Molar tooth sign on MRI (HP:0002419)2.76210229
32Abnormality of midbrain morphology (HP:0002418)2.76210229
33Tubular atrophy (HP:0000092)2.73618234
34Medial flaring of the eyebrow (HP:0010747)2.72486319
35Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.68582323
36Abnormal spermatogenesis (HP:0008669)2.67558239
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.61661600
38Cone-rod dystrophy (HP:0000548)2.58411270
39Recurrent bronchitis (HP:0002837)2.56825431
40Hypoplasia of the thymus (HP:0000778)2.48974891
41Tubulointerstitial abnormality (HP:0001969)2.47750124
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.43440320
43Chronic sinusitis (HP:0011109)2.42109591
44Unilateral renal agenesis (HP:0000122)2.34336398
45Abnormality of the aortic arch (HP:0012303)2.32466421
46Pancreatic fibrosis (HP:0100732)2.32359316
47Atelectasis (HP:0100750)2.30695930
48Postaxial foot polydactyly (HP:0001830)2.23096993
49Epiphyseal dysplasia (HP:0002656)2.20777346
50Hypoalphalipoproteinemia (HP:0003233)2.13913612
51Congenital hepatic fibrosis (HP:0002612)2.11965795
52True hermaphroditism (HP:0010459)2.11056720
53Tubulointerstitial fibrosis (HP:0005576)2.09814813
54Abnormality of the parathyroid morphology (HP:0011766)2.09142948
55Intellectual disability, moderate (HP:0002342)2.02342023
56Upper limb muscle weakness (HP:0003484)2.01722193
57Stage 5 chronic kidney disease (HP:0003774)2.00574908
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4795780
59Absent/shortened dynein arms (HP:0200106)12.5730454
60Dynein arm defect of respiratory motile cilia (HP:0012255)12.5730454
61Abnormal respiratory motile cilium physiology (HP:0012261)10.6588565
62Progressive cerebellar ataxia (HP:0002073)1.99961150
63Amblyopia (HP:0000646)1.99591850
64Optic nerve hypoplasia (HP:0000609)1.98913284
65Postural instability (HP:0002172)1.97825871
66Hyperthyroidism (HP:0000836)1.97652949
67Hand muscle atrophy (HP:0009130)1.95815682
68Cystic liver disease (HP:0006706)1.95359010
69Fibular hypoplasia (HP:0003038)1.94423497
70Absent epiphyses (HP:0010577)1.92872963
71Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92872963
72Amelogenesis imperfecta (HP:0000705)1.92224270
73Hyponatremia (HP:0002902)1.89359501
74Gonadotropin excess (HP:0000837)1.88347343
75Bile duct proliferation (HP:0001408)1.88072585
76Abnormal biliary tract physiology (HP:0012439)1.88072585
77Abnormality of dentin (HP:0010299)1.82132084
78Abnormal ventriculo-arterial connection (HP:0011563)1.81662476
79Transposition of the great arteries (HP:0001669)1.81662476
80Abnormal connection of the cardiac segments (HP:0011545)1.81662476
81Facial cleft (HP:0002006)1.81489609
82Abnormality of permanent molar morphology (HP:0011071)1.81177249
83Abnormality of the dental root (HP:0006486)1.81177249
84Taurodontia (HP:0000679)1.81177249
85Respiratory distress (HP:0002098)1.80927736
86Abnormality of the costochondral junction (HP:0000919)1.80915973
87Congenital primary aphakia (HP:0007707)1.79863525
88Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77314700
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.77091200
90Abnormality of the renal cortex (HP:0011035)1.76462161
91Gait imbalance (HP:0002141)1.76314159
92Supernumerary spleens (HP:0009799)1.73988838
93Abnormality of potassium homeostasis (HP:0011042)1.73835636
94Sensory axonal neuropathy (HP:0003390)1.72765755
95Abnormal drinking behavior (HP:0030082)1.72746696
96Polydipsia (HP:0001959)1.72746696
97Hypophosphatemic rickets (HP:0004912)1.72419065
98Impulsivity (HP:0100710)1.70872270
99Azoospermia (HP:0000027)1.69230409
100Abnormality of molar (HP:0011077)1.68750144
101Abnormality of molar morphology (HP:0011070)1.68750144
102Abnormality of dental color (HP:0011073)1.68589370
103Oculomotor apraxia (HP:0000657)1.68434288
104Abnormality of renal excretion (HP:0011036)1.68396814
105Abnormality of the pubic bones (HP:0003172)1.67345335
106Abnormality of the dental pulp (HP:0006479)1.66828866
107Pendular nystagmus (HP:0012043)1.66636878
108Postaxial hand polydactyly (HP:0001162)1.66542392
109Median cleft lip (HP:0000161)1.66204814
110Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66116705
111Flattened epiphyses (HP:0003071)1.65671701
112Pancreatic cysts (HP:0001737)1.65383416
113Occipital encephalocele (HP:0002085)1.64425767
114Renovascular hypertension (HP:0100817)1.63123316
115Horizontal nystagmus (HP:0000666)1.62758294
116Osteomalacia (HP:0002749)1.62667336
117Generalized aminoaciduria (HP:0002909)1.62466634
118Bell-shaped thorax (HP:0001591)1.62406513
119Insulin-resistant diabetes mellitus (HP:0000831)1.60220435
120Renal dysplasia (HP:0000110)1.55734453
121Short ribs (HP:0000773)1.54332535
122Nephrogenic diabetes insipidus (HP:0009806)1.53252763
123Decreased central vision (HP:0007663)1.52016387
124Abnormality of the lower motor neuron (HP:0002366)1.50616781
125Aplasia/Hypoplasia of the lens (HP:0008063)1.47588869
126Cholecystitis (HP:0001082)1.43035100
127Abnormal gallbladder physiology (HP:0012438)1.43035100
128Dyschromatopsia (HP:0007641)1.42937756
129Genital tract atresia (HP:0001827)1.40138834
130Vaginal atresia (HP:0000148)1.37031278
131Microglossia (HP:0000171)1.33358197
132Chronic hepatic failure (HP:0100626)1.31398307
133Choroideremia (HP:0001139)1.30762940
134Short thorax (HP:0010306)1.27989716
135Abnormal urine output (HP:0012590)1.27535364
136Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.26555633
137Absent frontal sinuses (HP:0002688)1.26071184
138Poor coordination (HP:0002370)1.24144256
139Aplasia/Hypoplasia of the fibula (HP:0006492)1.23982036
140Amyotrophic lateral sclerosis (HP:0007354)1.23772924
141Nephropathy (HP:0000112)1.23597638
142Anencephaly (HP:0002323)1.21627620
143Hypoplasia of the capital femoral epiphysis (HP:0003090)1.19909441
144Sclerocornea (HP:0000647)1.19308950
145Constricted visual fields (HP:0001133)1.16998424
146Deformed sella turcica (HP:0002681)1.13944856
147Polyuria (HP:0000103)1.13358261
148J-shaped sella turcica (HP:0002680)1.13209414
149Asymmetric septal hypertrophy (HP:0001670)1.13185021
150Short nail (HP:0001799)1.12009877
151Spastic tetraparesis (HP:0001285)1.11741458
152Preaxial hand polydactyly (HP:0001177)1.11718465
153Heterotopia (HP:0002282)1.10990013
154Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.09905900
155Congenital malformation of the right heart (HP:0011723)1.07777906
156Double outlet right ventricle (HP:0001719)1.07777906

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.02881291
2PDK39.02881291
3PDK25.83042153
4DDR24.94894365
5TESK14.81560405
6PRKD33.82627364
7MAP4K23.41577179
8INSRR3.32577464
9PLK23.26712852
10ICK3.21124875
11PNCK2.73059533
12BRD42.31728089
13WNK42.23970656
14STK392.22101072
15PTK2B2.21866376
16TRIM281.82719234
17MST1R1.65676136
18MAPK151.52197962
19NEK21.46016617
20STK381.35939327
21DYRK1B1.31530588
22CDK71.18900756
23LMTK21.14774299
24CAMK1D1.11233669
25PDK11.00938411
26AKT30.94644352
27MKNK20.93323217
28CDK80.92418870
29MAP3K20.91442108
30PIK3CG0.90494274
31BCR0.86513800
32KSR20.86169583
33IRAK10.84264375
34TYRO30.82392175
35DYRK30.79489727
36WNK10.76370366
37WEE10.70309804
38MAP3K80.69656143
39LATS20.68486704
40ACVR1B0.65714164
41STK30.63982231
42BRAF0.61596962
43PASK0.59811899
44CCNB10.59585226
45MAP3K90.59512865
46NUAK10.58242508
47NTRK30.56811538
48CAMK1G0.55778631
49RPS6KA20.55147309
50PRKAA20.55074811
51CASK0.52826520
52TAF10.51912152
53NTRK20.51835238
54STK38L0.51558967
55MUSK0.48763395
56CSNK1G30.48147842
57MAP2K60.47862343
58PDPK10.47775262
59ROCK10.47487204
60CSNK1A1L0.46300869
61NME10.44749603
62MAP3K110.43946048
63CHEK20.43078287
64PLK40.42984583
65TTK0.42412154
66CAMK10.41444579
67BRSK20.39948191
68CDK20.38891110
69EEF2K0.38611000
70PINK10.38410114
71CSNK1G20.37857069
72ZAK0.37472807
73LATS10.36571402
74SGK2230.35830088
75SGK4940.35830088
76SIK30.34445799
77GRK50.34394221
78CHEK10.33246815
79RIPK40.32772738
80EIF2AK30.32429142
81IRAK20.31920510
82KSR10.30728534
83MINK10.29570870
84NEK60.29382741
85PAK10.28916733
86STK100.28479090
87RPS6KA60.27688293
88PRKCG0.27655938
89UHMK10.26974223
90ATR0.26717687
91WNK30.26559983
92DYRK1A0.26395502
93CSNK1G10.26237473
94FRK0.26101449
95MST40.25647213
96MAPK10.25562683
97YES10.25245665
98PAK20.25157278
99SGK10.24536171
100MET0.24398149
101CAMKK10.24172447
102ATM0.22750520
103TESK20.21703967
104CDC70.21433757
105PKN10.20758408
106BUB10.20430496
107PRKCE0.20309002
108PRKG20.20174709
109MOS0.19393522
110MAP2K70.19355621
111CAMK40.18771303
112BRSK10.16644290
113PAK40.16547825
114GRK10.16529031
115PLK10.16375024
116TGFBR20.15487469
117PRKCZ0.14296717
118MTOR0.14180410
119PRKAA10.13008146
120MAP3K40.12300599
121GRK70.10042917
122MAPKAPK50.09810935
123PRKCQ0.09743947
124AURKA0.09662105
125MARK20.08756999
126CSNK2A10.08341060
127PRKG10.07315432
128ZAP700.06446129
129RPS6KB10.06147217
130CDK30.05903574
131PDGFRB0.05560965
132PRKACG0.05267305
133CDK150.03394478
134CAMK2A0.03057090
135CDK60.02891250
136GSK3B0.02848010
137MARK10.02326468
138RPS6KA10.02314065
139MAP3K100.02282033
140CDK180.01987433
141CSNK2A20.01847911
142EGFR0.01413851
143PRKACB0.01026176
144PRKACA0.01010665
145TIE10.00781210
146SRC0.00765389
147CDK10.00370093
148OXSR10.00176583
149PRKCB-0.0126203
150GSK3A-0.0115191
151MARK3-0.0094210
152PRKCD-0.0085684
153STK11-0.0055484
154PRKCA-0.0048503
155STK16-0.0044974
156PRKDC-0.0041763
157CDK11A-0.0038537
158MAPK8-0.0037897

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.24157359
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.37057488
3Pyruvate metabolism_Homo sapiens_hsa006203.89844442
4Vitamin B6 metabolism_Homo sapiens_hsa007503.77090998
5Olfactory transduction_Homo sapiens_hsa047403.72652300
6Fatty acid biosynthesis_Homo sapiens_hsa000613.66484668
7Propanoate metabolism_Homo sapiens_hsa006403.06081813
8Butanoate metabolism_Homo sapiens_hsa006502.79417903
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.74306154
10Linoleic acid metabolism_Homo sapiens_hsa005912.63701123
11Basal transcription factors_Homo sapiens_hsa030222.57399801
12Glucagon signaling pathway_Homo sapiens_hsa049222.54349954
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.40770898
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.24206541
15Phenylalanine metabolism_Homo sapiens_hsa003602.16066482
16Dorso-ventral axis formation_Homo sapiens_hsa043202.10165075
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.01036063
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.96897871
19Huntingtons disease_Homo sapiens_hsa050161.94729111
20Selenocompound metabolism_Homo sapiens_hsa004501.88076158
21Pentose phosphate pathway_Homo sapiens_hsa000301.86713372
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.84605808
23Oocyte meiosis_Homo sapiens_hsa041141.78693558
24Mineral absorption_Homo sapiens_hsa049781.74232228
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70904855
26Fanconi anemia pathway_Homo sapiens_hsa034601.69375542
27Glycerolipid metabolism_Homo sapiens_hsa005611.67534986
28PPAR signaling pathway_Homo sapiens_hsa033201.55224026
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54038402
30Arginine and proline metabolism_Homo sapiens_hsa003301.48912451
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.43212662
32Ether lipid metabolism_Homo sapiens_hsa005651.42870386
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.41810210
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37105565
35Cardiac muscle contraction_Homo sapiens_hsa042601.35718903
36Carbon metabolism_Homo sapiens_hsa012001.34717539
37Glutathione metabolism_Homo sapiens_hsa004801.34527522
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34031351
39Amphetamine addiction_Homo sapiens_hsa050311.33347508
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31465612
41Phototransduction_Homo sapiens_hsa047441.27596750
42Purine metabolism_Homo sapiens_hsa002301.26331312
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23023596
44beta-Alanine metabolism_Homo sapiens_hsa004101.22086808
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21787146
46Arginine biosynthesis_Homo sapiens_hsa002201.21062148
47Fructose and mannose metabolism_Homo sapiens_hsa000511.20616288
48Tyrosine metabolism_Homo sapiens_hsa003501.17657654
49Renin secretion_Homo sapiens_hsa049241.15647580
50Hedgehog signaling pathway_Homo sapiens_hsa043401.15616676
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14114510
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.13742921
53Type II diabetes mellitus_Homo sapiens_hsa049301.11854604
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.04068355
55Fat digestion and absorption_Homo sapiens_hsa049751.03453879
56Antigen processing and presentation_Homo sapiens_hsa046121.00352179
57Chemical carcinogenesis_Homo sapiens_hsa052040.99196811
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98585736
59Arachidonic acid metabolism_Homo sapiens_hsa005900.98536020
60mRNA surveillance pathway_Homo sapiens_hsa030150.98330024
61Fatty acid metabolism_Homo sapiens_hsa012120.91793976
62Fatty acid degradation_Homo sapiens_hsa000710.90849271
63Collecting duct acid secretion_Homo sapiens_hsa049660.88178588
64Renin-angiotensin system_Homo sapiens_hsa046140.87723567
65Sulfur metabolism_Homo sapiens_hsa009200.84912259
66Thyroid hormone synthesis_Homo sapiens_hsa049180.82809105
67Biosynthesis of amino acids_Homo sapiens_hsa012300.82464798
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81661134
69Nicotine addiction_Homo sapiens_hsa050330.80764381
70RNA transport_Homo sapiens_hsa030130.76463273
71Nitrogen metabolism_Homo sapiens_hsa009100.72107655
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71789484
73Estrogen signaling pathway_Homo sapiens_hsa049150.70626670
74Taste transduction_Homo sapiens_hsa047420.69847801
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69776619
76Insulin secretion_Homo sapiens_hsa049110.69555664
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.68410622
78Calcium signaling pathway_Homo sapiens_hsa040200.66792952
79Caffeine metabolism_Homo sapiens_hsa002320.65343272
80Basal cell carcinoma_Homo sapiens_hsa052170.64354975
81Morphine addiction_Homo sapiens_hsa050320.62972574
82Mismatch repair_Homo sapiens_hsa034300.62309993
83Bile secretion_Homo sapiens_hsa049760.62287830
84RNA degradation_Homo sapiens_hsa030180.61520753
85Protein digestion and absorption_Homo sapiens_hsa049740.61431355
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.60430192
87Homologous recombination_Homo sapiens_hsa034400.59932776
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57874144
89Long-term potentiation_Homo sapiens_hsa047200.56741518
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56395729
91Pyrimidine metabolism_Homo sapiens_hsa002400.55868567
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.55303261
93Gastric acid secretion_Homo sapiens_hsa049710.54805129
94One carbon pool by folate_Homo sapiens_hsa006700.54789313
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53416583
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53214992
97Salivary secretion_Homo sapiens_hsa049700.52281665
98Type I diabetes mellitus_Homo sapiens_hsa049400.52043579
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.50119361
100Inositol phosphate metabolism_Homo sapiens_hsa005620.48965361
101Peroxisome_Homo sapiens_hsa041460.48582728
102Nucleotide excision repair_Homo sapiens_hsa034200.48008853
103AMPK signaling pathway_Homo sapiens_hsa041520.46421195
104Pancreatic secretion_Homo sapiens_hsa049720.45775505
105Base excision repair_Homo sapiens_hsa034100.43269929
106Glutamatergic synapse_Homo sapiens_hsa047240.42692229
107Metabolic pathways_Homo sapiens_hsa011000.42107546
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41933274
109Wnt signaling pathway_Homo sapiens_hsa043100.41581597
110Endocytosis_Homo sapiens_hsa041440.40421261
111Viral myocarditis_Homo sapiens_hsa054160.40296331
112Circadian rhythm_Homo sapiens_hsa047100.39940673
113Proteasome_Homo sapiens_hsa030500.38177437
114Legionellosis_Homo sapiens_hsa051340.37635892
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37562295
116ABC transporters_Homo sapiens_hsa020100.37357317
117Allograft rejection_Homo sapiens_hsa053300.37344772
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37113312
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37063593
120Autoimmune thyroid disease_Homo sapiens_hsa053200.35557039
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35534467
122Systemic lupus erythematosus_Homo sapiens_hsa053220.35193956
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34766677
124GABAergic synapse_Homo sapiens_hsa047270.33979690
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33921289
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33902432
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.32403836
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32045987
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29619586
130Circadian entrainment_Homo sapiens_hsa047130.27196373
131cAMP signaling pathway_Homo sapiens_hsa040240.26747081
132Synaptic vesicle cycle_Homo sapiens_hsa047210.26230601
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26224641
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25319850
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24713262
136VEGF signaling pathway_Homo sapiens_hsa043700.21365544
137Tight junction_Homo sapiens_hsa045300.21285589
138Retinol metabolism_Homo sapiens_hsa008300.19527689
139Salmonella infection_Homo sapiens_hsa051320.16677696
140Alcoholism_Homo sapiens_hsa050340.11171863
141Cocaine addiction_Homo sapiens_hsa050300.10493849
142Cell cycle_Homo sapiens_hsa041100.10192837
143Viral carcinogenesis_Homo sapiens_hsa052030.07882392
144N-Glycan biosynthesis_Homo sapiens_hsa005100.06426492

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