ERLEC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.28598286
2COPI coating of Golgi vesicle (GO:0048205)5.28598286
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.11781567
4protein retention in ER lumen (GO:0006621)3.76705507
5COPII vesicle coating (GO:0048208)3.72493663
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.58918792
7regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.32869594
8positive regulation of actin filament depolymerization (GO:0030836)3.24282503
9peptide hormone processing (GO:0016486)3.21880084
10L-phenylalanine catabolic process (GO:0006559)3.16453827
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.16453827
12signal peptide processing (GO:0006465)3.16015064
13detection of calcium ion (GO:0005513)3.13634072
14endocrine pancreas development (GO:0031018)3.10534964
15ER overload response (GO:0006983)3.05200371
16positive regulation of protein autophosphorylation (GO:0031954)3.04372153
17regulation of glucokinase activity (GO:0033131)2.95897860
18regulation of hexokinase activity (GO:1903299)2.95897860
19negative regulation of neurological system process (GO:0031645)2.95717251
20vesicle coating (GO:0006901)2.92195225
21exocrine pancreas development (GO:0031017)2.92100894
22activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.88953603
23zinc ion transport (GO:0006829)2.79875557
24L-phenylalanine metabolic process (GO:0006558)2.77580695
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.77580695
26negative regulation of complement activation (GO:0045916)2.73629486
27cellular response to vitamin D (GO:0071305)2.71957150
28cell adhesion mediated by integrin (GO:0033627)2.71518481
29peroxisome fission (GO:0016559)2.71382333
30negative regulation of protein activation cascade (GO:2000258)2.69685912
31toxin metabolic process (GO:0009404)2.67738604
32sequestering of extracellular ligand from receptor (GO:0035581)2.67370595
33positive regulation of nuclease activity (GO:0032075)2.64426969
34UDP-N-acetylglucosamine metabolic process (GO:0006047)2.61016428
35protein maturation by protein folding (GO:0022417)2.60329750
36regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.60249395
37protein targeting to Golgi (GO:0000042)2.58175288
38vascular smooth muscle contraction (GO:0014829)2.54484142
39* ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.53653961
40lipid particle organization (GO:0034389)2.51925145
41regulation of metalloenzyme activity (GO:0048552)2.50188546
42cellular zinc ion homeostasis (GO:0006882)2.49890229
43protein hydroxylation (GO:0018126)2.49338992
44cullin deneddylation (GO:0010388)2.48710436
45membrane budding (GO:0006900)2.47924021
46regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.47585216
47ER to Golgi vesicle-mediated transport (GO:0006888)2.45905033
48endoplasmic reticulum unfolded protein response (GO:0030968)2.44345611
49regulation of type B pancreatic cell apoptotic process (GO:2000674)2.43552467
50insulin secretion (GO:0030073)2.42990298
51negative regulation of neurotransmitter secretion (GO:0046929)2.41643289
52tonic smooth muscle contraction (GO:0014820)2.41136552
53regulation of transforming growth factor beta1 production (GO:0032908)2.41125246
54negative regulation of hormone metabolic process (GO:0032351)2.40984842
55cellular response to unfolded protein (GO:0034620)2.40816927
56valine metabolic process (GO:0006573)2.40610539
57C4-dicarboxylate transport (GO:0015740)2.40557419
58cellular response to leptin stimulus (GO:0044320)2.40384552
59peptidyl-proline hydroxylation (GO:0019511)2.40328438
604-hydroxyproline metabolic process (GO:0019471)2.39862917
61artery smooth muscle contraction (GO:0014824)2.39699458
62establishment of protein localization to Golgi (GO:0072600)2.39270128
63xenobiotic catabolic process (GO:0042178)2.36916073
64L-serine transport (GO:0015825)2.36525554
65ER-nucleus signaling pathway (GO:0006984)2.35570013
66cellular response to vitamin (GO:0071295)2.35174368
67negative regulation of hormone biosynthetic process (GO:0032353)2.34577840
68protein localization to Golgi apparatus (GO:0034067)2.34002219
69protein localization to cilium (GO:0061512)2.32806330
70polyketide metabolic process (GO:0030638)2.32700355
71doxorubicin metabolic process (GO:0044598)2.32700355
72daunorubicin metabolic process (GO:0044597)2.32700355
73keratinocyte development (GO:0003334)2.31681801
74regulation of nuclease activity (GO:0032069)2.31059579
75water-soluble vitamin biosynthetic process (GO:0042364)2.29848582
76endoplasmic reticulum organization (GO:0007029)2.28685275
77coenzyme catabolic process (GO:0009109)2.28327418
78regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.28315298
79platelet dense granule organization (GO:0060155)2.28111845
80intra-Golgi vesicle-mediated transport (GO:0006891)2.28108278
81regulation of integrin-mediated signaling pathway (GO:2001044)2.27631226
82peptidyl-cysteine modification (GO:0018198)2.27525050
83cerebellar Purkinje cell layer development (GO:0021680)2.26630547
84axoneme assembly (GO:0035082)2.26412095
85nucleoside diphosphate catabolic process (GO:0009134)2.26353105
86zinc ion transmembrane transport (GO:0071577)2.26090385
87cellular response to topologically incorrect protein (GO:0035967)2.25393604
88glandular epithelial cell differentiation (GO:0002067)2.24075336
89Golgi to plasma membrane protein transport (GO:0043001)2.23536520
90type B pancreatic cell proliferation (GO:0044342)2.23194123
91regulation of extracellular matrix disassembly (GO:0010715)2.19803592
92Golgi organization (GO:0007030)2.19601629
93eye photoreceptor cell differentiation (GO:0001754)2.19525383
94photoreceptor cell differentiation (GO:0046530)2.19525383
95keratan sulfate catabolic process (GO:0042340)2.18894298
96positive regulation of mitochondrial fission (GO:0090141)2.18636718
97response to leptin (GO:0044321)2.17892612
98nucleotide-sugar metabolic process (GO:0009225)2.17766517
99inositol phosphate catabolic process (GO:0071545)2.16962409
100response to endoplasmic reticulum stress (GO:0034976)2.16870880
101cholesterol biosynthetic process (GO:0006695)2.16293967
102positive regulation of glycolytic process (GO:0045821)2.15442186
103cilium morphogenesis (GO:0060271)2.15398983
104branched-chain amino acid catabolic process (GO:0009083)2.15216823
105regulation of protein glycosylation (GO:0060049)2.15072401
106beta-amyloid metabolic process (GO:0050435)2.14821931
107sequestering of metal ion (GO:0051238)2.14784705
108branched-chain amino acid metabolic process (GO:0009081)2.14757016
109aromatic amino acid family catabolic process (GO:0009074)2.14596895
110collagen fibril organization (GO:0030199)2.14161373
111regulation of insulin secretion (GO:0050796)2.13864234
112nucleotide-sugar biosynthetic process (GO:0009226)2.13785556
113lactate metabolic process (GO:0006089)2.12162018
114positive regulation of fatty acid oxidation (GO:0046321)2.11519666
115regulation of fibrinolysis (GO:0051917)2.11408494
116sterol biosynthetic process (GO:0016126)2.11294257
117aminoglycoside antibiotic metabolic process (GO:0030647)2.09649414
118response to redox state (GO:0051775)2.09533685
119macroautophagy (GO:0016236)2.09495764
120protein carboxylation (GO:0018214)2.08882340
121peptidyl-glutamic acid carboxylation (GO:0017187)2.08882340
122melanosome transport (GO:0032402)2.08253351
123alanine transport (GO:0032328)2.08116111
124transcytosis (GO:0045056)2.08041736
125positive regulation of vesicle fusion (GO:0031340)2.08002730
126negative regulation of glycogen biosynthetic process (GO:0045719)2.07476097
127regulation of cilium movement (GO:0003352)2.07079588
128drug transmembrane transport (GO:0006855)2.06904946
129extracellular negative regulation of signal transduction (GO:1900116)2.06529304
130extracellular regulation of signal transduction (GO:1900115)2.06529304
131retrograde transport, vesicle recycling within Golgi (GO:0000301)2.06386875
132positive regulation of glycoprotein metabolic process (GO:1903020)2.06371996
133negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.06055156
134L-ascorbic acid metabolic process (GO:0019852)2.06053512
1353-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.05829463
136purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.05829463
137positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.05748955
138regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.05378226
139protein deneddylation (GO:0000338)2.05126786
140cell redox homeostasis (GO:0045454)2.05020017
141positive regulation of insulin secretion (GO:0032024)2.04600239
142positive regulation of TOR signaling (GO:0032008)2.03731769
143intestinal cholesterol absorption (GO:0030299)2.03446265
144cellular modified amino acid catabolic process (GO:0042219)2.01206737
145negative regulation of glycogen metabolic process (GO:0070874)2.01110797
146protein N-linked glycosylation via asparagine (GO:0018279)2.00752411
147type B pancreatic cell development (GO:0003323)2.00365993
148response to methylmercury (GO:0051597)2.00284741
149cellular response to glucagon stimulus (GO:0071377)2.00275763
150response to unfolded protein (GO:0006986)1.99133372
151peptide secretion (GO:0002790)1.99075292
152peptidyl-asparagine modification (GO:0018196)1.98333442
153regulation of synaptic vesicle exocytosis (GO:2000300)1.98273402
154chondrocyte development (GO:0002063)1.97468082
155presynaptic membrane assembly (GO:0097105)1.96983176
156inner ear receptor cell development (GO:0060119)1.96877228
157sulfur amino acid catabolic process (GO:0000098)1.96814163
158regulation of peptide hormone secretion (GO:0090276)1.96291078
159regulation of peptide secretion (GO:0002791)1.94959820
160protein N-linked glycosylation (GO:0006487)1.93823705
161peptide hormone secretion (GO:0030072)1.92880038
162hormone catabolic process (GO:0042447)1.92799501
163succinate metabolic process (GO:0006105)1.90612125
164response to topologically incorrect protein (GO:0035966)1.90381031
165short-chain fatty acid metabolic process (GO:0046459)1.89362314
166Golgi vesicle transport (GO:0048193)1.89334386
167regulation of energy homeostasis (GO:2000505)1.89290954
168regulation of beta-amyloid formation (GO:1902003)1.87932170
169positive regulation of glycogen biosynthetic process (GO:0045725)1.87586111
170membrane repolarization during cardiac muscle cell action potential (GO:0086013)1.86852183
171negative regulation of neurotransmitter transport (GO:0051589)1.86051670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human2.38317861
2FLI1_27457419_Chip-Seq_LIVER_Mouse2.20849103
3EZH2_22144423_ChIP-Seq_EOC_Human2.13721745
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.12787864
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11974669
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07581059
7FUS_26573619_Chip-Seq_HEK293_Human2.00867081
8RXR_22158963_ChIP-Seq_LIVER_Mouse1.94651339
9LXR_22158963_ChIP-Seq_LIVER_Mouse1.90971874
10CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88473293
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87630288
12SALL1_21062744_ChIP-ChIP_HESCs_Human1.85214428
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83496752
14PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.78264777
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77271788
16EZH2_27294783_Chip-Seq_NPCs_Mouse1.71749544
17SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70624673
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70390031
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.70153807
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69882181
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69875699
22TAF15_26573619_Chip-Seq_HEK293_Human1.68584863
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66208341
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66051129
25NRF2_20460467_ChIP-Seq_MEFs_Mouse1.62198946
26NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.62198946
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61993713
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59730130
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59712932
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53700965
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51930019
32CDX2_22108803_ChIP-Seq_LS180_Human1.48894441
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47218752
34ELK1_19687146_ChIP-ChIP_HELA_Human1.46574525
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45217238
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43956334
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.43282344
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43003696
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41434584
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41067226
41EWS_26573619_Chip-Seq_HEK293_Human1.40824184
42SMAD4_21799915_ChIP-Seq_A2780_Human1.39375666
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38622445
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.38514812
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.37230194
46BRD4_25478319_ChIP-Seq_HGPS_Human1.35323547
47IGF1R_20145208_ChIP-Seq_DFB_Human1.35273304
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34985059
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34150942
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.33796949
51AR_21572438_ChIP-Seq_LNCaP_Human1.33738745
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.32797361
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32434014
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.32183342
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.31806535
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31247915
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30407928
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30399882
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29960774
60* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29593187
61P53_22387025_ChIP-Seq_ESCs_Mouse1.28878510
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27175216
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26855629
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26659012
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25429894
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24335091
67DROSHA_22980978_ChIP-Seq_HELA_Human1.22904280
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.22708400
69CMYC_18555785_Chip-Seq_ESCs_Mouse1.22513212
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22356359
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22356359
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21487926
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20058398
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19582426
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18770832
76ZNF274_21170338_ChIP-Seq_K562_Hela1.18197504
77P300_19829295_ChIP-Seq_ESCs_Human1.17573981
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.17258401
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16368372
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.14387714
81STAT3_23295773_ChIP-Seq_U87_Human1.14038960
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13532212
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.13456170
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13308945
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13101449
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11024482
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10939177
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10568961
89CBP_20019798_ChIP-Seq_JUKART_Human1.10568961
90VDR_22108803_ChIP-Seq_LS180_Human1.10222080
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09929183
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09506413
93REST_21632747_ChIP-Seq_MESCs_Mouse1.09081277
94SOX2_18555785_Chip-Seq_ESCs_Mouse1.08982341
95TP53_18474530_ChIP-ChIP_U2OS_Human1.08727238
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.08597321
97* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08584749
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07134899
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.06991629
100CLOCK_20551151_ChIP-Seq_293T_Human1.06905057
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06834536
102EZH2_27304074_Chip-Seq_ESCs_Mouse1.05858942
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05751667
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05713542
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.05502010
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05069823
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05026162
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05003502
109ER_23166858_ChIP-Seq_MCF-7_Human1.04805632
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.03274108
111AHR_22903824_ChIP-Seq_MCF-7_Human1.03222240
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.03218003
113P300_18555785_Chip-Seq_ESCs_Mouse1.02818574
114SOX2_20726797_ChIP-Seq_SW620_Human1.02484973
115BCAT_22108803_ChIP-Seq_LS180_Human1.01435550
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01218931
117TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00959479
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.00589930
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00442984
120JUN_21703547_ChIP-Seq_K562_Human0.99764984
121CJUN_26792858_Chip-Seq_BT549_Human0.99613556
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98745839
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98488957
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.98327084
125AR_25329375_ChIP-Seq_VCAP_Human0.97679764
126FOXA2_19822575_ChIP-Seq_HepG2_Human0.96846890
127SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96054008
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.95603999
129TCF4_23295773_ChIP-Seq_U87_Human0.95310949
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95191749
131GATA1_22025678_ChIP-Seq_K562_Human0.94338133
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93127842
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92939554
134RXR_22108803_ChIP-Seq_LS180_Human0.92803008
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92662979
136RNF2_27304074_Chip-Seq_ESCs_Mouse0.92573283
137RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91840288
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90257273
139TCF4_22108803_ChIP-Seq_LS180_Human0.90163762
140FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88897357
141TP63_23658742_ChIP-Seq_EP156T_Human0.88239950
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87860275
143SMAD4_21741376_ChIP-Seq_EPCs_Human0.87524843
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86750752
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86154978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.72576164
2MP0003195_calcinosis3.46116376
3MP0004043_abnormal_pH_regulation3.37697206
4MP0006054_spinal_hemorrhage3.28863131
5MP0004272_abnormal_basement_membrane2.94606423
6MP0002909_abnormal_adrenal_gland2.92162858
7MP0002837_dystrophic_cardiac_calcinosis2.80651958
8MP0002139_abnormal_hepatobiliary_system2.76639881
9MP0000013_abnormal_adipose_tissue2.75597977
10MP0010386_abnormal_urinary_bladder2.41643462
11MP0005365_abnormal_bile_salt2.36928235
12MP0003283_abnormal_digestive_organ2.34907554
13MP0002877_abnormal_melanocyte_morpholog2.18695970
14MP0008438_abnormal_cutaneous_collagen2.07124372
15MP0005085_abnormal_gallbladder_physiolo2.04282716
16MP0005257_abnormal_intraocular_pressure1.91771908
17MP0003941_abnormal_skin_development1.91264673
18MP0002693_abnormal_pancreas_physiology1.82827884
19MP0001944_abnormal_pancreas_morphology1.80765393
20MP0008875_abnormal_xenobiotic_pharmacok1.80136013
21MP0010234_abnormal_vibrissa_follicle1.79882131
22MP0005058_abnormal_lysosome_morphology1.77532802
23MP0003252_abnormal_bile_duct1.73218502
24MP0002102_abnormal_ear_morphology1.68157634
25MP0002896_abnormal_bone_mineralization1.66897910
26MP0003183_abnormal_peptide_metabolism1.65904852
27MP0005360_urolithiasis1.65698916
28MP0001765_abnormal_ion_homeostasis1.61138278
29MP0005379_endocrine/exocrine_gland_phen1.60058181
30MP0001666_abnormal_nutrient_absorption1.55154916
31MP0005220_abnormal_exocrine_pancreas1.54956865
32MP0003868_abnormal_feces_composition1.52186611
33MP0005503_abnormal_tendon_morphology1.51074401
34MP0002876_abnormal_thyroid_physiology1.50523304
35MP0000516_abnormal_urinary_system1.47308663
36MP0005367_renal/urinary_system_phenotyp1.47308663
37MP0002078_abnormal_glucose_homeostasis1.46623108
38MP0000003_abnormal_adipose_tissue1.46334442
39MP0001986_abnormal_taste_sensitivity1.45768103
40MP0003329_amyloid_beta_deposits1.42284395
41MP0003880_abnormal_central_pattern1.37505691
42MP0005253_abnormal_eye_physiology1.36673892
43MP0005332_abnormal_amino_acid1.36045984
44MP0003950_abnormal_plasma_membrane1.35344602
45MP0010678_abnormal_skin_adnexa1.34372554
46MP0004270_analgesia1.32689994
47MP0009697_abnormal_copulation1.31858591
48MP0005646_abnormal_pituitary_gland1.30244149
49MP0005083_abnormal_biliary_tract1.28431845
50MP0001501_abnormal_sleep_pattern1.28341960
51MP0010352_gastrointestinal_tract_polyps1.28311835
52MP0004215_abnormal_myocardial_fiber1.26822230
53MP0003300_gastrointestinal_ulcer1.24778153
54MP0005535_abnormal_body_temperature1.24032076
55MP0003787_abnormal_imprinting1.23274419
56MP0005408_hypopigmentation1.20168406
57MP0002118_abnormal_lipid_homeostasis1.19811124
58MP0009643_abnormal_urine_homeostasis1.19722606
59MP0003279_aneurysm1.18358808
60MP0003690_abnormal_glial_cell1.18297743
61MP0005275_abnormal_skin_tensile1.17457087
62MP0001958_emphysema1.17160160
63MP0002295_abnormal_pulmonary_circulatio1.16309615
64MP0003121_genomic_imprinting1.13575708
65MP0005551_abnormal_eye_electrophysiolog1.13237219
66MP0004019_abnormal_vitamin_homeostasis1.12111213
67MP0002638_abnormal_pupillary_reflex1.11794596
68MP0002928_abnormal_bile_duct1.11399977
69MP0005084_abnormal_gallbladder_morpholo1.11079458
70MP0010329_abnormal_lipoprotein_level1.08844001
71MP0005636_abnormal_mineral_homeostasis1.06040066
72MP0001661_extended_life_span1.04953436
73MP0000230_abnormal_systemic_arterial1.04714208
74MP0009384_cardiac_valve_regurgitation1.04421696
75MP0005623_abnormal_meninges_morphology1.03344651
76MP0005645_abnormal_hypothalamus_physiol1.03127312
77MP0002064_seizures1.02980164
78MP0000538_abnormal_urinary_bladder1.01709820
79MP0005187_abnormal_penis_morphology1.01405890
80MP0000427_abnormal_hair_cycle0.99762923
81MP0003633_abnormal_nervous_system0.99122308
82MP0003953_abnormal_hormone_level0.98406501
83MP0003635_abnormal_synaptic_transmissio0.98139250
84MP0009046_muscle_twitch0.97554757
85MP0003172_abnormal_lysosome_physiology0.97179860
86MP0004036_abnormal_muscle_relaxation0.96605583
87MP0001664_abnormal_digestion0.96392782
88MP0010368_abnormal_lymphatic_system0.96358025
89MP0000920_abnormal_myelination0.95262575
90MP0003186_abnormal_redox_activity0.95079193
91MP0001756_abnormal_urination0.95058806
92MP0004859_abnormal_synaptic_plasticity0.93987055
93MP0001299_abnormal_eye_distance/0.93269941
94MP0000604_amyloidosis0.93092304
95MP0008775_abnormal_heart_ventricle0.92833951
96MP0004145_abnormal_muscle_electrophysio0.92815499
97MP0003122_maternal_imprinting0.91719070
98MP0000462_abnormal_digestive_system0.91083398
99MP0005164_abnormal_response_to0.89507051
100MP0004264_abnormal_extraembryonic_tissu0.88555680
101MP0002060_abnormal_skin_morphology0.87847586
102MP0003959_abnormal_lean_body0.87796791
103MP0002272_abnormal_nervous_system0.87387427
104MP0008961_abnormal_basal_metabolism0.86827037
105MP0000751_myopathy0.85522121
106MP0003045_fibrosis0.84888108
107MP0004134_abnormal_chest_morphology0.84293656
108MP0003011_delayed_dark_adaptation0.84118298
109MP0009745_abnormal_behavioral_response0.83480954
110MP0005334_abnormal_fat_pad0.83397815
111MP0002063_abnormal_learning/memory/cond0.83138565
112MP0006072_abnormal_retinal_apoptosis0.83090660
113MP0005310_abnormal_salivary_gland0.83082463
114MP0002168_other_aberrant_phenotype0.81135281
115MP0001270_distended_abdomen0.81127986
116MP0003634_abnormal_glial_cell0.80989940
117MP0001502_abnormal_circadian_rhythm0.79969280
118MP0004130_abnormal_muscle_cell0.79642625
119MP0002572_abnormal_emotion/affect_behav0.79274414
120MP0005448_abnormal_energy_balance0.79170874
121MP0001243_abnormal_dermal_layer0.79046855
122MP0004233_abnormal_muscle_weight0.78894119
123MP0003123_paternal_imprinting0.78808305
124MP0004782_abnormal_surfactant_physiolog0.78533745
125MP0000647_abnormal_sebaceous_gland0.78369367
126MP0002229_neurodegeneration0.77982218
127MP0001177_atelectasis0.77782513
128MP0002938_white_spotting0.76092224
129MP0005375_adipose_tissue_phenotype0.75854199
130MP0005395_other_phenotype0.75216762
131MP0004885_abnormal_endolymph0.74980243
132MP0008877_abnormal_DNA_methylation0.74725672
133MP0005508_abnormal_skeleton_morphology0.74238280
134MP0000163_abnormal_cartilage_morphology0.73534547
135MP0003937_abnormal_limbs/digits/tail_de0.72995294
136MP0002163_abnormal_gland_morphology0.72827936
137MP0003566_abnormal_cell_adhesion0.72807399
138MP0004085_abnormal_heartbeat0.72422457
139MP0002090_abnormal_vision0.72022449
140MP0000747_muscle_weakness0.71931331
141MP0005319_abnormal_enzyme/_coenzyme0.70330439
142MP0002734_abnormal_mechanical_nocicepti0.70242634
143MP0000639_abnormal_adrenal_gland0.69842300
144MP0003879_abnormal_hair_cell0.69529326
145MP0001542_abnormal_bone_strength0.69397749
146MP0001984_abnormal_olfaction0.68869677

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)4.14348577
2Hyperinsulinemic hypoglycemia (HP:0000825)3.93384514
3Ketoacidosis (HP:0001993)3.69057110
4Hypoglycemic coma (HP:0001325)3.64460180
5Symptomatic seizures (HP:0011145)3.62498742
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.61777006
7Mucopolysacchariduria (HP:0008155)3.39362040
8Urinary glycosaminoglycan excretion (HP:0003541)3.39362040
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.34798170
10Dysostosis multiplex (HP:0000943)3.21696264
11Abnormality of the intrinsic pathway (HP:0010989)3.08328594
12Abnormality of polysaccharide metabolism (HP:0011012)3.06223652
13Abnormality of glycosaminoglycan metabolism (HP:0004371)3.06223652
14Abnormality of mucopolysaccharide metabolism (HP:0011020)3.06223652
15Protuberant abdomen (HP:0001538)2.87947354
16Ketosis (HP:0001946)2.81415702
17Insulin-resistant diabetes mellitus (HP:0000831)2.79769080
18Epiphyseal dysplasia (HP:0002656)2.75159853
19Short tibia (HP:0005736)2.73766879
20Hyperglycemia (HP:0003074)2.71844888
21Medial flaring of the eyebrow (HP:0010747)2.61106184
22Mitral stenosis (HP:0001718)2.58619706
23Large for gestational age (HP:0001520)2.52986172
24Neurofibrillary tangles (HP:0002185)2.49182584
25Cardiovascular calcification (HP:0011915)2.47728449
26Intestinal atresia (HP:0011100)2.44881260
27Aplasia/Hypoplasia of the tibia (HP:0005772)2.43397627
28Methylmalonic acidemia (HP:0002912)2.37085907
29Increased serum pyruvate (HP:0003542)2.36048674
30Agitation (HP:0000713)2.34441738
31Abnormality of calcium-phosphate metabolism (HP:0100530)2.33837908
32Delayed gross motor development (HP:0002194)2.33221579
33Skin nodule (HP:0200036)2.33173801
34Congenital primary aphakia (HP:0007707)2.33118430
35Generalized aminoaciduria (HP:0002909)2.32911474
36Abnormal tarsal ossification (HP:0008369)2.32715522
37Retinal atrophy (HP:0001105)2.31961862
38Proximal tubulopathy (HP:0000114)2.30916294
39Abnormality of dentin (HP:0010299)2.28906506
40Ovoid vertebral bodies (HP:0003300)2.28060757
41Vascular calcification (HP:0004934)2.26800309
42Follicular hyperkeratosis (HP:0007502)2.26660275
43Aortic dissection (HP:0002647)2.26354611
44Gait imbalance (HP:0002141)2.25541907
45Tetraparesis (HP:0002273)2.25449677
46Neuroendocrine neoplasm (HP:0100634)2.25079770
47Type I transferrin isoform profile (HP:0003642)2.21379239
48Decreased circulating renin level (HP:0003351)2.20889950
49Hypokinesia (HP:0002375)2.20073032
50Conjugated hyperbilirubinemia (HP:0002908)2.19502687
51Abnormality of the common coagulation pathway (HP:0010990)2.18987624
52Pheochromocytoma (HP:0002666)2.15846928
53Hypoplastic ischia (HP:0003175)2.14142054
54Abnormality of vitamin B metabolism (HP:0004340)2.13765017
55Protrusio acetabuli (HP:0003179)2.13260886
56Gout (HP:0001997)2.13044459
57Type II lissencephaly (HP:0007260)2.12874942
58Disproportionate short-trunk short stature (HP:0003521)2.12448665
59Abnormality of the ischium (HP:0003174)2.11247241
60Hypobetalipoproteinemia (HP:0003563)2.10499932
61Atonic seizures (HP:0010819)2.09313780
62Abnormality of proline metabolism (HP:0010907)2.08067626
63Hydroxyprolinuria (HP:0003080)2.08067626
64Xanthomatosis (HP:0000991)2.07236569
65Intrahepatic cholestasis (HP:0001406)2.06598343
66Abnormality of vitamin metabolism (HP:0100508)2.06499867
67Cerebral inclusion bodies (HP:0100314)2.05507813
68Hypokalemia (HP:0002900)2.04611375
69Hypolipoproteinemia (HP:0010981)2.03413688
70Beaking of vertebral bodies (HP:0004568)2.02403626
71Abnormality of the pancreatic islet cells (HP:0006476)2.01666778
72Abnormality of endocrine pancreas physiology (HP:0012093)2.01666778
73Vascular tortuosity (HP:0004948)1.99576800
74Nephrogenic diabetes insipidus (HP:0009806)1.98646454
75Abnormality of glycolysis (HP:0004366)1.97727026
76Ankle contracture (HP:0006466)1.94192911
77Metaphyseal dysplasia (HP:0100255)1.93049556
78Intention tremor (HP:0002080)1.92664005
79Progressive neurologic deterioration (HP:0002344)1.92345862
80Increased circulating renin level (HP:0000848)1.92097258
81Thyroid carcinoma (HP:0002890)1.91264779
82Global brain atrophy (HP:0002283)1.91255136
83Tongue fasciculations (HP:0001308)1.88603770
84Diminished movement (HP:0002374)1.88070251
85Pancreatic islet-cell hyperplasia (HP:0004510)1.87896265
86Hyperactive renin-angiotensin system (HP:0000841)1.87871677
87Abdominal distention (HP:0003270)1.87851632
88Papilledema (HP:0001085)1.87751450
89Abnormality of renin-angiotensin system (HP:0000847)1.86859939
90Oligomenorrhea (HP:0000876)1.86009055
91Abnormality of methionine metabolism (HP:0010901)1.84924040
92Vacuolated lymphocytes (HP:0001922)1.84880268
93Fat malabsorption (HP:0002630)1.83605327
94Hyperkalemia (HP:0002153)1.83457941
95Abnormality of potassium homeostasis (HP:0011042)1.82804864
96Abnormality of purine metabolism (HP:0004352)1.82174358
97Epidermoid cyst (HP:0200040)1.82097066
98Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.79782659
99Arterial tortuosity (HP:0005116)1.79301615
100Hypoalphalipoproteinemia (HP:0003233)1.79193827
101Renal cortical cysts (HP:0000803)1.78139552
102Hypokalemic alkalosis (HP:0001949)1.77717762
103Occipital encephalocele (HP:0002085)1.77520669
104Progressive macrocephaly (HP:0004481)1.77252346
105Late onset (HP:0003584)1.76795424
106Genital tract atresia (HP:0001827)1.76665107
107Hypoplasia of the fovea (HP:0007750)1.76484412
108Aplasia/Hypoplasia of the fovea (HP:0008060)1.76484412
109Methylmalonic aciduria (HP:0012120)1.76177105
110Papillary thyroid carcinoma (HP:0002895)1.75676852
111Rhinitis (HP:0012384)1.75384245
112Focal motor seizures (HP:0011153)1.74905161
113Cervical subluxation (HP:0003308)1.73948376
114Prolonged partial thromboplastin time (HP:0003645)1.73883941
115Abnormal protein glycosylation (HP:0012346)1.72176969
116Abnormal glycosylation (HP:0012345)1.72176969
117Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72176969
118Abnormal protein N-linked glycosylation (HP:0012347)1.72176969
119Deep venous thrombosis (HP:0002625)1.71618131
120Hemiparesis (HP:0001269)1.71513364
121Osteomalacia (HP:0002749)1.70994915
122Soft skin (HP:0000977)1.70497578
123Testicular neoplasm (HP:0010788)1.70209723
124Palpitations (HP:0001962)1.70138091
125Hyperlipoproteinemia (HP:0010980)1.69450736
126Absence seizures (HP:0002121)1.69394703
127EEG with generalized epileptiform discharges (HP:0011198)1.68285336
128Epileptic encephalopathy (HP:0200134)1.68131523
129Microglossia (HP:0000171)1.67645201
130Exocrine pancreatic insufficiency (HP:0001738)1.65127050
131Postural tremor (HP:0002174)1.65042221
132Vaginal atresia (HP:0000148)1.64872748
133Asymmetric septal hypertrophy (HP:0001670)1.64652584
134Abnormality of chloride homeostasis (HP:0011422)1.64329604
135Epileptiform EEG discharges (HP:0011182)1.64259779
136Irregular vertebral endplates (HP:0003301)1.64252966
137Abnormal pancreas size (HP:0012094)1.63570724
138Visual hallucinations (HP:0002367)1.62815499
139Pancreatic fibrosis (HP:0100732)1.62366249
140Retinal dysplasia (HP:0007973)1.62264294
141Abnormality of the vitreous humor (HP:0004327)1.62150131
142Premature rupture of membranes (HP:0001788)1.60902938
143Hypsarrhythmia (HP:0002521)1.60098748
144Abnormal foot bone ossification (HP:0010675)1.58870992
145Osteoarthritis (HP:0002758)1.58634419
146Muscular hypotonia of the trunk (HP:0008936)1.58566582
147Aplasia involving bones of the upper limbs (HP:0009823)1.58443913
148Aplasia of the phalanges of the hand (HP:0009802)1.58443913
149Aplasia involving bones of the extremities (HP:0009825)1.58443913
150Congenital glaucoma (HP:0001087)1.57899387
151Abnormality of aspartate family amino acid metabolism (HP:0010899)1.57493941
152Abnormality of the vitamin B12 metabolism (HP:0004341)1.57046288
153Bronchomalacia (HP:0002780)1.56993605
154Thoracolumbar scoliosis (HP:0002944)1.56962377
155Abnormality of the fovea (HP:0000493)1.56199191
156Hypothermia (HP:0002045)1.56139760
157Macroorchidism (HP:0000053)1.55490734
158Action tremor (HP:0002345)1.54998095
159Exercise-induced muscle cramps (HP:0003710)1.54173689
160Metaphyseal irregularity (HP:0003025)1.53919201
161Aplasia/Hypoplasia of the tongue (HP:0010295)1.53796409
162Postaxial hand polydactyly (HP:0001162)1.52418963
163Hypophosphatemia (HP:0002148)1.51824546
164Hyperphosphatemia (HP:0002905)1.51468929
165Acute hepatic failure (HP:0006554)1.50973207
166Dialeptic seizures (HP:0011146)1.48728130
167Degeneration of the lateral corticospinal tracts (HP:0002314)1.47908172
168Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.47908172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.29075655
2TRIM283.71622258
3MAPK153.04669260
4WNK42.99393097
5FRK2.86319836
6MAP3K122.70250892
7LIMK12.64804840
8EIF2AK32.62939472
9STK392.49871628
10TAOK32.41218726
11MAP3K22.38271166
12BCKDK2.05129028
13PRKD31.95434723
14TESK11.94268444
15NTRK11.80862244
16NTRK31.79485248
17ERN11.75932863
18NEK11.72157177
19OXSR11.68980178
20STK38L1.68519560
21MAPK131.64412656
22PASK1.55571535
23PDK31.55531957
24PDK41.55531957
25CSNK1G11.52473743
26EPHA31.49620131
27PAK31.49450890
28PDK21.46721097
29MAPKAPK31.46175160
30CSNK1G31.44288207
31MAP4K21.43479360
32IRAK11.40824932
33NME11.37934018
34AKT31.37209121
35HIPK21.36751285
36DDR21.33331292
37SIK11.26598601
38WNK11.23276991
39EPHB11.18859445
40IRAK31.18727265
41MAP2K71.15656400
42ERBB31.14907943
43MAP3K11.14721126
44GRK11.13155677
45IRAK21.12794047
46MET1.09125731
47SCYL21.06769555
48PRKCH1.06447912
49SGK2231.00522017
50SGK4941.00522017
51STK31.00280431
52FER0.99424993
53PLK30.98561211
54EIF2AK10.98331899
55PTK60.97826820
56TRIB30.96794037
57PRKCE0.96749716
58SIK30.96376243
59BCR0.95817187
60FLT30.92943544
61KSR20.92174046
62MAP2K40.89691498
63PDGFRA0.88511424
64EPHA40.88372961
65BMPR20.86527486
66BRSK20.86519854
67TGFBR20.85731039
68MST40.85249845
69MAP3K40.85163386
70BMPR1B0.84015905
71PIK3CG0.82845957
72ADRBK20.82184429
73TRPM70.81863219
74ROCK10.81388293
75PTK20.80652464
76CAMK2D0.79512300
77PTK2B0.79150387
78WNK30.78756239
79CAMKK20.78698874
80ROCK20.77811832
81UHMK10.77571056
82PINK10.76798959
83MST1R0.75623284
84PNCK0.74684523
85FGFR20.73903597
86CDC42BPA0.73469893
87NEK90.70626283
88SGK20.70033247
89RET0.69574991
90ACVR1B0.68999667
91JAK10.68857949
92MAP2K10.67674807
93SGK30.67010249
94ARAF0.66746940
95EPHA20.66635547
96CAMK2A0.65158336
97DAPK10.64422876
98LMTK20.63186778
99NUAK10.63067104
100CDK50.59783375
101PAK60.59287529
102JAK20.58549325
103FGFR10.58544874
104PHKG10.58473259
105PHKG20.58473259
106PDPK10.57516400
107CAMKK10.55551152
108PRKCQ0.55139028
109DAPK20.54849886
110CAMK1G0.53789443
111CAMK2B0.52652585
112CAMK2G0.52342618
113CSNK1G20.52184391
114LATS10.51744757
115GRK50.51164611
116WEE10.51086400
117PAK40.50046162
118PLK20.49912395
119FGFR30.48895615
120RPS6KA40.48561886
121MAPK70.48373551
122CASK0.47998044
123MAP3K30.47261439
124SGK10.47239405
125NEK60.46835899
126MYLK0.45642467
127PIK3CA0.44170023
128STK240.43915864
129CSNK1A1L0.43763774
130ADRBK10.43588988
131TNK20.43245408
132PRKCG0.42588524
133MINK10.42366954
134ERBB40.42244179
135CSNK1A10.41613466
136PDK10.41264641
137TIE10.40881568
138SRPK10.40719599
139STK380.40704001
140MARK10.37341069
141BRSK10.37171296
142EIF2AK20.36786184
143PRKAA10.36201644
144PRKG10.32174176

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.77083245
2Protein export_Homo sapiens_hsa030603.10074820
3Sulfur metabolism_Homo sapiens_hsa009203.09269086
4Vitamin B6 metabolism_Homo sapiens_hsa007502.16881283
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88531775
6Insulin secretion_Homo sapiens_hsa049111.88086122
7* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.82825793
8Vibrio cholerae infection_Homo sapiens_hsa051101.69464867
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59285843
10Glutathione metabolism_Homo sapiens_hsa004801.56714474
11Butanoate metabolism_Homo sapiens_hsa006501.55930118
12Fatty acid degradation_Homo sapiens_hsa000711.47264404
13Collecting duct acid secretion_Homo sapiens_hsa049661.46028177
14Propanoate metabolism_Homo sapiens_hsa006401.44857152
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31218395
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29906663
17Pancreatic secretion_Homo sapiens_hsa049721.23851748
18Tryptophan metabolism_Homo sapiens_hsa003801.22482676
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22275808
20Lysosome_Homo sapiens_hsa041421.22179019
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17151333
22GABAergic synapse_Homo sapiens_hsa047271.17145450
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15817902
24Fatty acid metabolism_Homo sapiens_hsa012121.15658693
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13510748
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.13316823
27Synaptic vesicle cycle_Homo sapiens_hsa047211.10702595
28Cocaine addiction_Homo sapiens_hsa050301.09576644
29Fatty acid elongation_Homo sapiens_hsa000621.08123878
30Thyroid hormone synthesis_Homo sapiens_hsa049181.06516310
31Pyruvate metabolism_Homo sapiens_hsa006201.06461568
32Nitrogen metabolism_Homo sapiens_hsa009101.05259315
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04448048
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01662876
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99266206
36Starch and sucrose metabolism_Homo sapiens_hsa005000.98931427
37Type II diabetes mellitus_Homo sapiens_hsa049300.98563153
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96144116
39Retinol metabolism_Homo sapiens_hsa008300.95698235
40Amphetamine addiction_Homo sapiens_hsa050310.95228704
41Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94902886
42Histidine metabolism_Homo sapiens_hsa003400.94761880
43Bile secretion_Homo sapiens_hsa049760.92280725
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90843089
45Protein digestion and absorption_Homo sapiens_hsa049740.90398381
46Oxidative phosphorylation_Homo sapiens_hsa001900.89673341
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89146806
48Mineral absorption_Homo sapiens_hsa049780.88819848
49Circadian entrainment_Homo sapiens_hsa047130.87204457
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87026470
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.85887446
52Taste transduction_Homo sapiens_hsa047420.85702908
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85224653
54Caffeine metabolism_Homo sapiens_hsa002320.85059476
55Arginine biosynthesis_Homo sapiens_hsa002200.84603000
56N-Glycan biosynthesis_Homo sapiens_hsa005100.84302900
57Peroxisome_Homo sapiens_hsa041460.83911928
58Phenylalanine metabolism_Homo sapiens_hsa003600.83725144
59Long-term potentiation_Homo sapiens_hsa047200.80865372
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80716158
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80231838
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.78229831
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77998286
64Renin secretion_Homo sapiens_hsa049240.77214911
65beta-Alanine metabolism_Homo sapiens_hsa004100.76763282
66Fat digestion and absorption_Homo sapiens_hsa049750.75232034
67Dopaminergic synapse_Homo sapiens_hsa047280.74959713
68Morphine addiction_Homo sapiens_hsa050320.74062783
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73601135
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73242171
71Alzheimers disease_Homo sapiens_hsa050100.72006804
72Serotonergic synapse_Homo sapiens_hsa047260.71824667
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71771482
74Other glycan degradation_Homo sapiens_hsa005110.71679351
75Steroid biosynthesis_Homo sapiens_hsa001000.71406857
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71254977
77Tyrosine metabolism_Homo sapiens_hsa003500.70655899
78PPAR signaling pathway_Homo sapiens_hsa033200.70622736
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70509979
80ABC transporters_Homo sapiens_hsa020100.70086854
81Gastric acid secretion_Homo sapiens_hsa049710.68651912
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68651304
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67875116
84Glucagon signaling pathway_Homo sapiens_hsa049220.66808263
85Folate biosynthesis_Homo sapiens_hsa007900.66534249
86Metabolic pathways_Homo sapiens_hsa011000.65463936
87Salivary secretion_Homo sapiens_hsa049700.65211353
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64986011
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64813817
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64795836
91Cholinergic synapse_Homo sapiens_hsa047250.62869157
92Phototransduction_Homo sapiens_hsa047440.61508993
93Proteasome_Homo sapiens_hsa030500.61279414
94Sphingolipid metabolism_Homo sapiens_hsa006000.60941268
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.60574899
96Chemical carcinogenesis_Homo sapiens_hsa052040.60150938
97Glutamatergic synapse_Homo sapiens_hsa047240.59702341
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59344569
99TGF-beta signaling pathway_Homo sapiens_hsa043500.59083712
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58179548
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57300864
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56774779
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56624538
104Glycerolipid metabolism_Homo sapiens_hsa005610.56443047
105Carbon metabolism_Homo sapiens_hsa012000.55048172
106Insulin resistance_Homo sapiens_hsa049310.54228528
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53862955
108Nicotine addiction_Homo sapiens_hsa050330.52725634
109Ovarian steroidogenesis_Homo sapiens_hsa049130.52384340
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52164915
111Fatty acid biosynthesis_Homo sapiens_hsa000610.51939604
112Type I diabetes mellitus_Homo sapiens_hsa049400.51694531
113Complement and coagulation cascades_Homo sapiens_hsa046100.50569744
114Fructose and mannose metabolism_Homo sapiens_hsa000510.50133709
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48773792
116Selenocompound metabolism_Homo sapiens_hsa004500.48457048
117Arginine and proline metabolism_Homo sapiens_hsa003300.47990320
118Long-term depression_Homo sapiens_hsa047300.47969380
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46317417
120Galactose metabolism_Homo sapiens_hsa000520.46203162
121Circadian rhythm_Homo sapiens_hsa047100.44932908
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44248892
123ECM-receptor interaction_Homo sapiens_hsa045120.43948415
124Oocyte meiosis_Homo sapiens_hsa041140.43665956
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43536228
126Regulation of autophagy_Homo sapiens_hsa041400.41483694
127Renin-angiotensin system_Homo sapiens_hsa046140.41404063
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41245351
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38703469
130Tight junction_Homo sapiens_hsa045300.36331190

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