ERLEC1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.48293841
2somatic hypermutation of immunoglobulin genes (GO:0016446)4.75596734
3somatic diversification of immune receptors via somatic mutation (GO:0002566)4.75596734
4pyrimidine nucleobase catabolic process (GO:0006208)4.68736278
5histone H2A acetylation (GO:0043968)4.41605203
6DNA damage response, detection of DNA damage (GO:0042769)4.26024020
7protein localization to cilium (GO:0061512)3.94812156
8negative regulation of DNA recombination (GO:0045910)3.81284845
9chromatin remodeling at centromere (GO:0031055)3.72102327
10nucleobase catabolic process (GO:0046113)3.68628796
11DNA replication-dependent nucleosome organization (GO:0034723)3.64154883
12DNA replication-dependent nucleosome assembly (GO:0006335)3.64154883
13presynaptic membrane assembly (GO:0097105)3.62909599
14resolution of meiotic recombination intermediates (GO:0000712)3.61450172
15CENP-A containing nucleosome assembly (GO:0034080)3.59087653
16regulation of development, heterochronic (GO:0040034)3.44787821
17spindle checkpoint (GO:0031577)3.41958546
18protein localization to kinetochore (GO:0034501)3.41321794
19mitotic spindle checkpoint (GO:0071174)3.38143207
20mitotic metaphase plate congression (GO:0007080)3.36782048
21metaphase plate congression (GO:0051310)3.33499728
22neuron cell-cell adhesion (GO:0007158)3.29269789
23cullin deneddylation (GO:0010388)3.25759293
24DNA catabolic process, exonucleolytic (GO:0000738)3.22474339
25female gonad development (GO:0008585)3.20003135
26histone exchange (GO:0043486)3.16652223
27negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16106614
28negative regulation of mitotic sister chromatid separation (GO:2000816)3.16106614
29negative regulation of sister chromatid segregation (GO:0033046)3.16106614
30negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16106614
31negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16106614
32replication fork processing (GO:0031297)3.16106005
33regulation of mitotic spindle checkpoint (GO:1903504)3.15241962
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15241962
35olfactory bulb development (GO:0021772)3.15002502
36generation of neurons (GO:0048699)3.14906371
37kinetochore assembly (GO:0051382)3.13321241
38L-serine metabolic process (GO:0006563)3.09236658
39mitotic spindle assembly checkpoint (GO:0007094)3.06458407
40negative regulation of chromosome segregation (GO:0051985)3.06088370
41regulation of nuclear cell cycle DNA replication (GO:0033262)3.05065016
42proteasome assembly (GO:0043248)3.04649036
43spindle assembly checkpoint (GO:0071173)3.02941600
44DNA replication-independent nucleosome organization (GO:0034724)3.02685361
45DNA replication-independent nucleosome assembly (GO:0006336)3.02685361
46neural tube formation (GO:0001841)3.01328998
47microtubule depolymerization (GO:0007019)2.99575015
48presynaptic membrane organization (GO:0097090)2.97727473
49kinetochore organization (GO:0051383)2.96725563
50DNA ligation (GO:0006266)2.96547420
51regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96337416
52regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96337416
53intraciliary transport (GO:0042073)2.95149509
54positive regulation of mitochondrial fission (GO:0090141)2.94345607
55protein deneddylation (GO:0000338)2.92737838
56telomere maintenance via semi-conservative replication (GO:0032201)2.91332688
57regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.90915778
58negative regulation of DNA-dependent DNA replication (GO:2000104)2.88100466
59DNA integration (GO:0015074)2.87631051
60nucleotide-excision repair, DNA gap filling (GO:0006297)2.87002047
61protein polyglutamylation (GO:0018095)2.86566930
62glycosphingolipid biosynthetic process (GO:0006688)2.86525490
63maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.86393609
64regulation of DNA endoreduplication (GO:0032875)2.85886016
65regulation of timing of cell differentiation (GO:0048505)2.84841452
66cholesterol biosynthetic process (GO:0006695)2.83962246
67cilium morphogenesis (GO:0060271)2.81348348
68mitotic recombination (GO:0006312)2.81203468
69mitotic spindle organization (GO:0007052)2.79146440
70postreplication repair (GO:0006301)2.78945793
71sequestering of actin monomers (GO:0042989)2.78580541
72isoprenoid biosynthetic process (GO:0008299)2.77303701
73regulation of sister chromatid segregation (GO:0033045)2.76167993
74regulation of mitotic sister chromatid separation (GO:0010965)2.76167993
75regulation of mitotic sister chromatid segregation (GO:0033047)2.76167993
76somite development (GO:0061053)2.74867580
77termination of RNA polymerase II transcription (GO:0006369)2.74567561
78DNA strand elongation involved in DNA replication (GO:0006271)2.73848430
79regulation of helicase activity (GO:0051095)2.70944591
80mRNA splice site selection (GO:0006376)2.69306128
81histone mRNA metabolic process (GO:0008334)2.69132392
82recombinational repair (GO:0000725)2.68857454
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.68403363
84protein K11-linked ubiquitination (GO:0070979)2.66685917
85platelet dense granule organization (GO:0060155)2.65009694
86synapsis (GO:0007129)2.64360051
87retinal ganglion cell axon guidance (GO:0031290)2.62484902
88positive regulation of mRNA processing (GO:0050685)2.62317343
89DNA strand elongation (GO:0022616)2.62206443
90short-term memory (GO:0007614)2.61925779
91ATP-dependent chromatin remodeling (GO:0043044)2.61724296
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60754662
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60754662
94regulation of mRNA splicing, via spliceosome (GO:0048024)2.60708985
95sister chromatid segregation (GO:0000819)2.60392040
96translesion synthesis (GO:0019985)2.59682975
97centriole replication (GO:0007099)2.59656006
98telomere maintenance via recombination (GO:0000722)2.58902584
99double-strand break repair via homologous recombination (GO:0000724)2.58364166
100postsynaptic membrane organization (GO:0001941)2.55552656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.11914194
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.07418201
3MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.54420317
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.32944806
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.32330011
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00575609
7IGF1R_20145208_ChIP-Seq_DFB_Human3.00262180
8TAF15_26573619_Chip-Seq_HEK293_Human2.79714385
9ZNF274_21170338_ChIP-Seq_K562_Hela2.73958654
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43022518
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.37646014
12FUS_26573619_Chip-Seq_HEK293_Human2.28682608
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28497443
14EWS_26573619_Chip-Seq_HEK293_Human2.27174008
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.26594741
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14035488
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12936394
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.12271325
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10150220
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05954145
21GBX2_23144817_ChIP-Seq_PC3_Human2.02848095
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95334369
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92225682
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85111010
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84435928
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84407525
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83445940
28ELK1_19687146_ChIP-ChIP_HELA_Human1.79509821
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76910612
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74178418
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74084835
32VDR_22108803_ChIP-Seq_LS180_Human1.73541822
33IRF1_19129219_ChIP-ChIP_H3396_Human1.71974170
34P300_19829295_ChIP-Seq_ESCs_Human1.70734147
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64922197
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64321654
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61732814
38MYC_18940864_ChIP-ChIP_HL60_Human1.59091074
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57797514
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54956062
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52038098
42VDR_23849224_ChIP-Seq_CD4+_Human1.50632008
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46899760
44CBP_20019798_ChIP-Seq_JUKART_Human1.43942734
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43942734
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38203436
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37791429
48FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36386532
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34896204
50RNF2_27304074_Chip-Seq_NSC_Mouse1.34241113
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.34095821
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.31379487
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30870056
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29936265
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29410801
56FOXP3_21729870_ChIP-Seq_TREG_Human1.28391969
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26913558
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26111908
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25088943
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24005808
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23843144
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20897586
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20897586
64SOX2_16153702_ChIP-ChIP_HESCs_Human1.20825994
65SMAD4_21799915_ChIP-Seq_A2780_Human1.19884625
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18995290
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17315236
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.15846597
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15446074
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14656444
71ER_23166858_ChIP-Seq_MCF-7_Human1.12903311
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.08308657
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08002192
74GABP_19822575_ChIP-Seq_HepG2_Human1.05204078
75MYC_18555785_ChIP-Seq_MESCs_Mouse1.04410050
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02632671
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02584575
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.02318523
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01643914
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01606297
81TAL1_26923725_Chip-Seq_HPCs_Mouse0.99548375
82GATA1_26923725_Chip-Seq_HPCs_Mouse0.99071987
83SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98745582
84MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97160047
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.96694993
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96323891
87DCP1A_22483619_ChIP-Seq_HELA_Human0.96252198
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95847993
89BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95828586
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95548324
91AR_25329375_ChIP-Seq_VCAP_Human0.95191550
92SOX9_26525672_Chip-Seq_HEART_Mouse0.94343679
93AR_21909140_ChIP-Seq_LNCAP_Human0.94140108
94E2F1_21310950_ChIP-Seq_MCF-7_Human0.94087258
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92841267
96SOX2_19829295_ChIP-Seq_ESCs_Human0.92635093
97NANOG_19829295_ChIP-Seq_ESCs_Human0.92635093
98HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91596210
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91519570
100RUNX2_22187159_ChIP-Seq_PCA_Human0.90753866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.54126555
2MP0001529_abnormal_vocalization3.29903048
3MP0010094_abnormal_chromosome_stability3.07436091
4MP0003121_genomic_imprinting2.66421660
5MP0008058_abnormal_DNA_repair2.63409806
6MP0006292_abnormal_olfactory_placode2.58740766
7MP0003122_maternal_imprinting2.36691209
8MP0002102_abnormal_ear_morphology2.31527285
9MP0003693_abnormal_embryo_hatching2.19303329
10MP0000778_abnormal_nervous_system2.13801857
11MP0006276_abnormal_autonomic_nervous2.11245952
12MP0008789_abnormal_olfactory_epithelium2.06485768
13MP0004270_analgesia2.05876471
14MP0005394_taste/olfaction_phenotype1.98255544
15MP0005499_abnormal_olfactory_system1.98255544
16MP0003787_abnormal_imprinting1.95949195
17MP0005187_abnormal_penis_morphology1.89216398
18MP0001984_abnormal_olfaction1.80513499
19MP0001293_anophthalmia1.79749290
20MP0008057_abnormal_DNA_replication1.72494652
21MP0003111_abnormal_nucleus_morphology1.72425947
22MP0002736_abnormal_nociception_after1.71361756
23MP0008995_early_reproductive_senescence1.68171569
24MP0008877_abnormal_DNA_methylation1.67732007
25MP0008932_abnormal_embryonic_tissue1.66925022
26MP0002234_abnormal_pharynx_morphology1.63614727
27MP0002653_abnormal_ependyma_morphology1.62406391
28MP0002751_abnormal_autonomic_nervous1.60975610
29MP0003077_abnormal_cell_cycle1.57462205
30MP0004957_abnormal_blastocyst_morpholog1.55993179
31MP0000647_abnormal_sebaceous_gland1.55829069
32MP0003119_abnormal_digestive_system1.53953242
33MP0005248_abnormal_Harderian_gland1.51055279
34MP0005423_abnormal_somatic_nervous1.50234085
35MP0004859_abnormal_synaptic_plasticity1.49572984
36MP0000372_irregular_coat_pigmentation1.48366754
37MP0003315_abnormal_perineum_morphology1.46840008
38MP0003567_abnormal_fetal_cardiomyocyte1.41986155
39MP0001188_hyperpigmentation1.41707253
40MP0000049_abnormal_middle_ear1.41304804
41MP0002938_white_spotting1.39609191
42MP0004133_heterotaxia1.38656660
43MP0000631_abnormal_neuroendocrine_gland1.36279482
44MP0001986_abnormal_taste_sensitivity1.32408730
45MP0003136_yellow_coat_color1.31406188
46MP0002233_abnormal_nose_morphology1.29756994
47MP0001486_abnormal_startle_reflex1.29712518
48MP0003718_maternal_effect1.29474048
49MP0002928_abnormal_bile_duct1.28627194
50MP0006072_abnormal_retinal_apoptosis1.27547621
51MP0009046_muscle_twitch1.27345680
52MP0003221_abnormal_cardiomyocyte_apopto1.25243982
53MP0003937_abnormal_limbs/digits/tail_de1.24766061
54MP0005253_abnormal_eye_physiology1.23169865
55MP0001346_abnormal_lacrimal_gland1.21940137
56MP0003137_abnormal_impulse_conducting1.21057010
57MP0002734_abnormal_mechanical_nocicepti1.19912642
58MP0003635_abnormal_synaptic_transmissio1.14126176
59MP0001968_abnormal_touch/_nociception1.13714686
60MP0003861_abnormal_nervous_system1.13511292
61MP0002272_abnormal_nervous_system1.11036774
62MP0000566_synostosis1.10057706
63MP0001286_abnormal_eye_development1.09142858
64MP0003698_abnormal_male_reproductive1.08336165
65MP0002697_abnormal_eye_size1.07335164
66MP0003890_abnormal_embryonic-extraembry1.06968526
67MP0004215_abnormal_myocardial_fiber1.06099689
68MP0003786_premature_aging1.05517981
69MP0001929_abnormal_gametogenesis1.05508391
70MP0004147_increased_porphyrin_level1.02777197
71MP0003938_abnormal_ear_development1.02438881
72MP0003123_paternal_imprinting1.02090471
73MP0005391_vision/eye_phenotype1.00875096
74MP0008007_abnormal_cellular_replicative0.98049800
75MP0005551_abnormal_eye_electrophysiolog0.96872395
76MP0002063_abnormal_learning/memory/cond0.95469280
77MP0006035_abnormal_mitochondrial_morpho0.95216043
78MP0002210_abnormal_sex_determination0.93971611
79MP0003385_abnormal_body_wall0.93520091
80MP0002557_abnormal_social/conspecific_i0.92958210
81MP0000653_abnormal_sex_gland0.91697019
82MP0009745_abnormal_behavioral_response0.91090181
83MP0001177_atelectasis0.89518182
84MP0002752_abnormal_somatic_nervous0.89482082
85MP0005195_abnormal_posterior_eye0.88921331
86MP0002282_abnormal_trachea_morphology0.87991956
87MP0002152_abnormal_brain_morphology0.87882455
88MP0005386_behavior/neurological_phenoty0.87621750
89MP0004924_abnormal_behavior0.87621750
90MP0001299_abnormal_eye_distance/0.87512502
91MP0003755_abnormal_palate_morphology0.87065449
92MP0002735_abnormal_chemical_nociception0.86424373
93MP0003195_calcinosis0.84822491
94MP0003943_abnormal_hepatobiliary_system0.83287614
95MP0002092_abnormal_eye_morphology0.83029542
96MP0004811_abnormal_neuron_physiology0.82896573
97MP0005084_abnormal_gallbladder_morpholo0.81967967
98MP0001145_abnormal_male_reproductive0.80254933
99MP0002882_abnormal_neuron_morphology0.80219379
100MP0001485_abnormal_pinna_reflex0.80122285

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.73073673
2True hermaphroditism (HP:0010459)3.57666777
3Medulloblastoma (HP:0002885)3.35777055
4Pancreatic fibrosis (HP:0100732)3.27697068
5Pancreatic cysts (HP:0001737)3.15856749
6Abnormality of midbrain morphology (HP:0002418)3.10956253
7Molar tooth sign on MRI (HP:0002419)3.10956253
8Nephrogenic diabetes insipidus (HP:0009806)3.08098589
9Abnormality of the labia minora (HP:0012880)3.02073518
10Gait imbalance (HP:0002141)2.93587182
11Congenital primary aphakia (HP:0007707)2.93018894
12Medial flaring of the eyebrow (HP:0010747)2.82525938
13Chronic hepatic failure (HP:0100626)2.80413720
14Ependymoma (HP:0002888)2.74608705
15Glioma (HP:0009733)2.74543593
16Nephronophthisis (HP:0000090)2.65626079
17Cortical dysplasia (HP:0002539)2.62464844
18Lissencephaly (HP:0001339)2.62396205
19Genital tract atresia (HP:0001827)2.61655422
20Progressive inability to walk (HP:0002505)2.61254114
21Vaginal atresia (HP:0000148)2.58843676
22Colon cancer (HP:0003003)2.54971020
23Carpal bone hypoplasia (HP:0001498)2.50965563
24Birth length less than 3rd percentile (HP:0003561)2.50119134
25Aplasia/Hypoplasia of the tongue (HP:0010295)2.49485230
26Meckel diverticulum (HP:0002245)2.48566834
27Retinal dysplasia (HP:0007973)2.45351407
28Oligodactyly (hands) (HP:0001180)2.44894185
29Abnormality of chromosome stability (HP:0003220)2.44391233
30Hypoplastic pelvis (HP:0008839)2.40404407
31Sloping forehead (HP:0000340)2.39543847
32Abnormality of the ileum (HP:0001549)2.38561417
33Pendular nystagmus (HP:0012043)2.32777086
34Rhabdomyosarcoma (HP:0002859)2.26292043
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.21867170
36Broad foot (HP:0001769)2.21829115
37B lymphocytopenia (HP:0010976)2.19482115
38Abnormality of the astrocytes (HP:0100707)2.16677955
39Astrocytoma (HP:0009592)2.16677955
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.16192469
41Patellar aplasia (HP:0006443)2.16173043
42Methylmalonic acidemia (HP:0002912)2.15685742
43Cystic liver disease (HP:0006706)2.12856832
44Abnormal lung lobation (HP:0002101)2.12337010
45Hyperglycinemia (HP:0002154)2.11689555
46Aplasia/Hypoplasia of the sternum (HP:0006714)2.11372804
47Occipital encephalocele (HP:0002085)2.11329511
48Agnosia (HP:0010524)2.11203777
49Postaxial foot polydactyly (HP:0001830)2.09687232
50Dandy-Walker malformation (HP:0001305)2.09180913
51Abnormality of the renal medulla (HP:0100957)2.04062523
52Oligodactyly (HP:0012165)2.03923015
53Postaxial hand polydactyly (HP:0001162)2.03369961
54Renal hypoplasia (HP:0000089)2.02227538
55Urinary urgency (HP:0000012)1.99589719
56Decreased testicular size (HP:0008734)1.99048938
57Aplasia/Hypoplasia of the patella (HP:0006498)1.99010086
58Drooling (HP:0002307)1.94152520
59Sclerocornea (HP:0000647)1.94084216
60Tubulointerstitial nephritis (HP:0001970)1.93789183
61Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91105142
62Poor coordination (HP:0002370)1.90848342
63Small hand (HP:0200055)1.89842773
64Degeneration of the lateral corticospinal tracts (HP:0002314)1.87479010
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87479010
66Narrow forehead (HP:0000341)1.87221455
67Bifid tongue (HP:0010297)1.87037792
68Irregular epiphyses (HP:0010582)1.85905562
69Specific learning disability (HP:0001328)1.84813425
70Inability to walk (HP:0002540)1.84777456
71Broad-based gait (HP:0002136)1.84632459
72Gonadotropin excess (HP:0000837)1.83350900
73Preaxial hand polydactyly (HP:0001177)1.82521660
74Nephroblastoma (Wilms tumor) (HP:0002667)1.82191336
75Optic nerve coloboma (HP:0000588)1.82184908
76Hip dysplasia (HP:0001385)1.80872166
77Small intestinal stenosis (HP:0012848)1.80859432
78Duodenal stenosis (HP:0100867)1.80859432
79Exotropia (HP:0000577)1.80704389
80Abnormality of B cell number (HP:0010975)1.80294869
81Anencephaly (HP:0002323)1.79613983
82Atonic seizures (HP:0010819)1.78625847
83Abnormality of glycine metabolism (HP:0010895)1.78336727
84Abnormality of serine family amino acid metabolism (HP:0010894)1.78336727
85Limb dystonia (HP:0002451)1.77381937
86Multicystic kidney dysplasia (HP:0000003)1.74607346
87Pachygyria (HP:0001302)1.73032147
88Astigmatism (HP:0000483)1.72645553
89Poor suck (HP:0002033)1.72381160
90Embryonal renal neoplasm (HP:0011794)1.72096278
91Abnormal biliary tract physiology (HP:0012439)1.70238716
92Bile duct proliferation (HP:0001408)1.70238716
93Methylmalonic aciduria (HP:0012120)1.70180117
94Excessive salivation (HP:0003781)1.70149742
95Chorioretinal coloboma (HP:0000567)1.68377768
96Hypoplastic female external genitalia (HP:0012815)1.67667946
97Failure to thrive in infancy (HP:0001531)1.67546790
98Focal motor seizures (HP:0011153)1.66994734
99Abnormality of the metopic suture (HP:0005556)1.64555434
100Labial hypoplasia (HP:0000066)1.62910964

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.97510216
2WNK33.88637018
3TRIM283.21293646
4SRPK13.07088243
5MARK12.86862335
6BCR2.72541156
7MKNK12.68777788
8MAP3K42.62810321
9MKNK22.45551671
10MAP3K102.28941579
11MAP2K72.19399306
12BUB12.12429307
13CDC72.12170801
14NEK12.08349772
15ZAK2.05018544
16DYRK32.01072860
17EIF2AK31.91851708
18MAPK131.70763355
19BMPR1B1.68376134
20NLK1.64491873
21CSNK1A1L1.63957569
22WEE11.62638882
23CSNK1G31.57988015
24ERBB31.55860400
25CSNK1G21.55082868
26NUAK11.47859624
27PLK31.47323304
28PINK11.46164269
29DYRK21.45050180
30CASK1.44855786
31TTK1.42626776
32CSNK1G11.41041058
33PLK41.40146967
34RPS6KA41.36813567
35MINK11.26121394
36SIK31.25325394
37PLK11.18560486
38EPHA41.13453165
39TSSK61.08972293
40ACVR1B1.08813025
41BRD41.05706677
42STK38L1.00207553
43BRSK20.99906115
44ATR0.94917828
45MAP4K20.93835528
46BCKDK0.92445022
47NEK20.91781380
48FRK0.90632037
49PLK20.81012615
50PKN10.80721715
51VRK10.76089965
52NTRK20.72576109
53VRK20.71416868
54MAP2K40.68350014
55PRKCG0.67673745
56PAK30.66580950
57ATM0.65081722
58TGFBR10.63714653
59KSR10.59301525
60PRKCE0.58969444
61UHMK10.58205212
62AURKB0.55237997
63LIMK10.54972050
64BRSK10.54635114
65CDK180.53811639
66CCNB10.53414306
67EPHB20.52638462
68GRK10.50531753
69CDK140.49148965
70MAP3K50.49007125
71EIF2AK10.48565766
72CAMK2A0.47414781
73CHEK20.46210484
74DAPK10.45258931
75CDK30.44902633
76MUSK0.44403229
77DYRK1A0.42329239
78CDK150.41491897
79PBK0.41251057
80MAP3K60.39084635
81SIK20.38553716
82PRKD30.36194552
83CDK11A0.36173227
84EIF2AK20.35198814
85CDK50.35130871
86CSNK1A10.33816064
87AURKA0.33482950
88INSRR0.33415448
89CSNK2A10.32895206
90PAK60.32173274
91EPHA30.31132896
92CDK10.29726831
93PASK0.29389174
94AKT30.29307464
95PRKDC0.29067962
96CSNK1D0.27028416
97STK160.26529572
98CSNK1E0.26357118
99CHEK10.25350713
100STK30.21292493

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.60959531
2Non-homologous end-joining_Homo sapiens_hsa034503.35876981
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.08225258
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.97120509
5DNA replication_Homo sapiens_hsa030302.85065357
6Steroid biosynthesis_Homo sapiens_hsa001002.81805227
7Protein export_Homo sapiens_hsa030602.52744183
8Propanoate metabolism_Homo sapiens_hsa006402.40966298
9Nicotine addiction_Homo sapiens_hsa050332.36274702
10Fanconi anemia pathway_Homo sapiens_hsa034602.35325100
11Homologous recombination_Homo sapiens_hsa034402.23528149
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22429523
13Base excision repair_Homo sapiens_hsa034102.21260621
14Butanoate metabolism_Homo sapiens_hsa006502.06550528
15Proteasome_Homo sapiens_hsa030501.97304847
16Cell cycle_Homo sapiens_hsa041101.90118805
17RNA transport_Homo sapiens_hsa030131.82222896
18Spliceosome_Homo sapiens_hsa030401.79401539
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69168042
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65820033
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55100030
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.52185119
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50841031
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45972333
25RNA degradation_Homo sapiens_hsa030181.43691226
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43476645
27Nucleotide excision repair_Homo sapiens_hsa034201.42905841
28Basal transcription factors_Homo sapiens_hsa030221.41902663
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41171230
30RNA polymerase_Homo sapiens_hsa030201.36858912
31Fatty acid elongation_Homo sapiens_hsa000621.32159934
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31118846
33Oocyte meiosis_Homo sapiens_hsa041141.31098975
34Phototransduction_Homo sapiens_hsa047441.23406977
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22968418
36mRNA surveillance pathway_Homo sapiens_hsa030151.18842320
37GABAergic synapse_Homo sapiens_hsa047271.17573354
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13325081
39Fatty acid metabolism_Homo sapiens_hsa012121.12838007
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07838372
41Parkinsons disease_Homo sapiens_hsa050121.07754904
42Selenocompound metabolism_Homo sapiens_hsa004501.06632031
43Pyrimidine metabolism_Homo sapiens_hsa002401.06620969
44Purine metabolism_Homo sapiens_hsa002301.01173245
45Taste transduction_Homo sapiens_hsa047421.00793381
46beta-Alanine metabolism_Homo sapiens_hsa004100.99109629
47Oxidative phosphorylation_Homo sapiens_hsa001900.98586899
48Biosynthesis of amino acids_Homo sapiens_hsa012300.96916679
49One carbon pool by folate_Homo sapiens_hsa006700.96657030
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96534266
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95479847
52Pyruvate metabolism_Homo sapiens_hsa006200.95072326
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94801374
54Basal cell carcinoma_Homo sapiens_hsa052170.88867731
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85250379
56Peroxisome_Homo sapiens_hsa041460.81848833
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79946750
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77303308
59Carbon metabolism_Homo sapiens_hsa012000.73379365
60Hedgehog signaling pathway_Homo sapiens_hsa043400.69789033
61Regulation of autophagy_Homo sapiens_hsa041400.69184837
62Glutathione metabolism_Homo sapiens_hsa004800.67784020
63Huntingtons disease_Homo sapiens_hsa050160.65646950
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63884875
65Morphine addiction_Homo sapiens_hsa050320.60959940
66Fatty acid degradation_Homo sapiens_hsa000710.59984810
67p53 signaling pathway_Homo sapiens_hsa041150.59630348
68Hippo signaling pathway_Homo sapiens_hsa043900.56078399
69Colorectal cancer_Homo sapiens_hsa052100.55316123
70Olfactory transduction_Homo sapiens_hsa047400.54798629
71Wnt signaling pathway_Homo sapiens_hsa043100.53305404
72Axon guidance_Homo sapiens_hsa043600.53158063
73Dopaminergic synapse_Homo sapiens_hsa047280.52854327
74Thyroid cancer_Homo sapiens_hsa052160.51939673
75Alcoholism_Homo sapiens_hsa050340.50501010
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49077844
77Metabolic pathways_Homo sapiens_hsa011000.48880239
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48755388
79Collecting duct acid secretion_Homo sapiens_hsa049660.48353589
80Arginine and proline metabolism_Homo sapiens_hsa003300.46170376
81Synaptic vesicle cycle_Homo sapiens_hsa047210.45635710
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43356765
83Lysine degradation_Homo sapiens_hsa003100.42066385
84Glutamatergic synapse_Homo sapiens_hsa047240.41823528
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40581960
86Tryptophan metabolism_Homo sapiens_hsa003800.39715268
87Circadian entrainment_Homo sapiens_hsa047130.36313429
88Nitrogen metabolism_Homo sapiens_hsa009100.35669279
89Alzheimers disease_Homo sapiens_hsa050100.35181313
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34801011
91Adherens junction_Homo sapiens_hsa045200.33004245
92Folate biosynthesis_Homo sapiens_hsa007900.29843387
93Vitamin digestion and absorption_Homo sapiens_hsa049770.27786169
94Circadian rhythm_Homo sapiens_hsa047100.27260306
95Ether lipid metabolism_Homo sapiens_hsa005650.26763982
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26513224
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25618282
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25085522
99Serotonergic synapse_Homo sapiens_hsa047260.23953093
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22116982

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