ERLIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.97627801
2L-phenylalanine catabolic process (GO:0006559)5.97627801
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.78011344
4L-phenylalanine metabolic process (GO:0006558)5.78011344
5aromatic amino acid family catabolic process (GO:0009074)5.66624001
6tryptophan catabolic process (GO:0006569)5.36270505
7indole-containing compound catabolic process (GO:0042436)5.36270505
8indolalkylamine catabolic process (GO:0046218)5.36270505
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.34033169
10urea metabolic process (GO:0019627)5.23810073
11urea cycle (GO:0000050)5.23810073
12kynurenine metabolic process (GO:0070189)5.19347415
13tryptophan metabolic process (GO:0006568)5.16952492
14cysteine metabolic process (GO:0006534)5.00841650
15glyoxylate metabolic process (GO:0046487)4.99265578
16sulfur amino acid catabolic process (GO:0000098)4.95374810
17bile acid biosynthetic process (GO:0006699)4.89360806
18alpha-linolenic acid metabolic process (GO:0036109)4.86296398
19nitrogen cycle metabolic process (GO:0071941)4.74453701
20homocysteine metabolic process (GO:0050667)4.74130863
21high-density lipoprotein particle remodeling (GO:0034375)4.72652321
22protein carboxylation (GO:0018214)4.71962346
23peptidyl-glutamic acid carboxylation (GO:0017187)4.71962346
24negative regulation of fibrinolysis (GO:0051918)4.70768000
25complement activation, alternative pathway (GO:0006957)4.68526915
26COPI coating of Golgi vesicle (GO:0048205)4.65786002
27Golgi transport vesicle coating (GO:0048200)4.65786002
28regulation of protein activation cascade (GO:2000257)4.62430596
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.60555747
30lysine metabolic process (GO:0006553)4.49871367
31lysine catabolic process (GO:0006554)4.49871367
32serine family amino acid catabolic process (GO:0009071)4.40845564
33amino-acid betaine metabolic process (GO:0006577)4.39002056
34regulation of triglyceride catabolic process (GO:0010896)4.38639191
35regulation of complement activation (GO:0030449)4.36724965
36DNA unwinding involved in DNA replication (GO:0006268)4.35144334
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.34483195
38nuclear pore complex assembly (GO:0051292)4.32074664
39regulation of fibrinolysis (GO:0051917)4.30472340
40mitotic chromosome condensation (GO:0007076)4.29176473
41phospholipid efflux (GO:0033700)4.23611128
42reverse cholesterol transport (GO:0043691)4.22303184
43bile acid metabolic process (GO:0008206)4.19145208
44negative regulation of sterol transport (GO:0032372)4.19019576
45negative regulation of cholesterol transport (GO:0032375)4.19019576
46glycine metabolic process (GO:0006544)4.18995535
47protein-lipid complex remodeling (GO:0034368)4.13102229
48macromolecular complex remodeling (GO:0034367)4.13102229
49plasma lipoprotein particle remodeling (GO:0034369)4.13102229
50aromatic amino acid family metabolic process (GO:0009072)4.09854365
51protein retention in ER lumen (GO:0006621)4.05835433
52plasma lipoprotein particle clearance (GO:0034381)4.03225934
53serine family amino acid metabolic process (GO:0009069)3.98791984
54serine family amino acid biosynthetic process (GO:0009070)3.98051673
55regulation of cholesterol esterification (GO:0010872)3.95035495
56bile acid and bile salt transport (GO:0015721)3.90289905
57pinocytosis (GO:0006907)3.86822672
58tyrosine metabolic process (GO:0006570)3.86517831
59alpha-amino acid catabolic process (GO:1901606)3.84156297
60urate metabolic process (GO:0046415)3.83555806
61acylglycerol homeostasis (GO:0055090)3.77094976
62triglyceride homeostasis (GO:0070328)3.77094976
63ethanol oxidation (GO:0006069)3.74393355
64drug catabolic process (GO:0042737)3.74182885
65indolalkylamine metabolic process (GO:0006586)3.71253709
66cellular glucuronidation (GO:0052695)3.70625798
67cholesterol efflux (GO:0033344)3.68282516
68nuclear pore organization (GO:0006999)3.67676613
69fibrinolysis (GO:0042730)3.67269756
70positive regulation of lipoprotein lipase activity (GO:0051006)3.65950013
71positive regulation of triglyceride lipase activity (GO:0061365)3.65950013
72plasma lipoprotein particle assembly (GO:0034377)3.63408039
73drug transmembrane transport (GO:0006855)3.59940262
74phospholipid homeostasis (GO:0055091)3.58263382
75cellular amino acid catabolic process (GO:0009063)3.56564775
76cellular modified amino acid catabolic process (GO:0042219)3.54342204
77killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.53860307
78disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.53860307
79benzene-containing compound metabolic process (GO:0042537)3.53560956
80regulation of cholesterol homeostasis (GO:2000188)3.51765742
81lipoprotein metabolic process (GO:0042157)3.50411014
82imidazole-containing compound metabolic process (GO:0052803)3.47384166
83cellular biogenic amine catabolic process (GO:0042402)3.47304354
84amine catabolic process (GO:0009310)3.47304354
85dicarboxylic acid biosynthetic process (GO:0043650)3.46938751
86glutamate metabolic process (GO:0006536)3.46262920
87cellular ketone body metabolic process (GO:0046950)3.43564720
88cholesterol homeostasis (GO:0042632)3.43413161
89establishment of integrated proviral latency (GO:0075713)3.41628966
90sterol homeostasis (GO:0055092)3.41028502
91DNA strand elongation involved in DNA replication (GO:0006271)3.38554203
92protein-lipid complex assembly (GO:0065005)3.38430577
93DNA strand elongation (GO:0022616)3.38198673
94carnitine metabolic process (GO:0009437)3.37886357
95mitotic sister chromatid segregation (GO:0000070)3.37484399
96low-density lipoprotein particle remodeling (GO:0034374)3.36839930
97positive regulation of lipid catabolic process (GO:0050996)3.35244035
98aldehyde catabolic process (GO:0046185)3.35021509
99cell adhesion mediated by integrin (GO:0033627)3.33647860
100telomere maintenance via semi-conservative replication (GO:0032201)3.32945659
101glucuronate metabolic process (GO:0019585)3.32224481
102uronic acid metabolic process (GO:0006063)3.32224481
103skin morphogenesis (GO:0043589)3.31816389
104proline biosynthetic process (GO:0006561)3.30265290
105sister chromatid segregation (GO:0000819)3.29069986
106plasma lipoprotein particle organization (GO:0071827)3.27646718
107DNA topological change (GO:0006265)3.27513273
108protein localization to chromosome, centromeric region (GO:0071459)3.27291481
1092-oxoglutarate metabolic process (GO:0006103)3.23805719
110coenzyme catabolic process (GO:0009109)3.23330249
111regulation of plasminogen activation (GO:0010755)3.22444513
112pyridine nucleotide biosynthetic process (GO:0019363)3.21703434
113nicotinamide nucleotide biosynthetic process (GO:0019359)3.21703434
114mitotic metaphase plate congression (GO:0007080)3.21381428
115protein maturation by protein folding (GO:0022417)3.21020874
116drug transport (GO:0015893)3.20823004
117very-low-density lipoprotein particle assembly (GO:0034379)3.19232963
118arginine metabolic process (GO:0006525)3.17109510
119complement activation (GO:0006956)3.17062155
120pore complex assembly (GO:0046931)3.15910457
121protein-lipid complex subunit organization (GO:0071825)3.15450858
122complement activation, classical pathway (GO:0006958)3.14465658
123primary alcohol catabolic process (GO:0034310)3.13266073
124ethanol metabolic process (GO:0006067)3.13032904
125hypotonic response (GO:0006971)3.11014185
126protein localization to kinetochore (GO:0034501)3.01387844
127COPII vesicle coating (GO:0048208)3.01242102
128hepatocyte differentiation (GO:0070365)2.89512838
129nucleotide-sugar biosynthetic process (GO:0009226)2.85264513
130telomere maintenance via recombination (GO:0000722)2.84676079
131hemidesmosome assembly (GO:0031581)2.84053263
132regulation of mitotic spindle organization (GO:0060236)2.82695046
133mitotic recombination (GO:0006312)2.81381028
134mitotic sister chromatid cohesion (GO:0007064)2.79218731
135ribosome assembly (GO:0042255)2.77876151
136metaphase plate congression (GO:0051310)2.76578803
137regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.75812663
138establishment of chromosome localization (GO:0051303)2.73128927
139protein hydroxylation (GO:0018126)2.70283616
140mitotic nuclear envelope disassembly (GO:0007077)2.70159576
141chromosome condensation (GO:0030261)2.69901011
142nucleobase-containing small molecule interconversion (GO:0015949)2.66855743
143formation of translation preinitiation complex (GO:0001731)2.66758790
144regulation of translational fidelity (GO:0006450)2.66651508
145regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.61299055
146hyaluronan catabolic process (GO:0030214)2.61157300
147pentose-phosphate shunt (GO:0006098)2.60176138
148regulation of spindle organization (GO:0090224)2.57763566
149NADPH regeneration (GO:0006740)2.57123535
150nuclear envelope disassembly (GO:0051081)2.52048214
151membrane disassembly (GO:0030397)2.52048214
152DNA replication initiation (GO:0006270)2.51440496
153DNA ligation (GO:0006266)2.49004868
154proline metabolic process (GO:0006560)2.46963876
155peptidyl-proline hydroxylation (GO:0019511)2.46222271
156positive regulation of nuclease activity (GO:0032075)2.45878995
157DNA duplex unwinding (GO:0032508)2.43725682
158protein N-linked glycosylation via asparagine (GO:0018279)2.42836750
159establishment of viral latency (GO:0019043)2.42512843
160peptidyl-asparagine modification (GO:0018196)2.42252369
161UDP-N-acetylglucosamine metabolic process (GO:0006047)2.42109598
162heterochromatin organization (GO:0070828)2.36600644
163DNA conformation change (GO:0071103)2.36407884
164glucose catabolic process (GO:0006007)2.35466630
165activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.34046472
166regulation of sister chromatid cohesion (GO:0007063)2.33892654
167DNA geometric change (GO:0032392)2.32680199
168regulation of apoptotic cell clearance (GO:2000425)2.32253321
169regulation of mammary gland epithelial cell proliferation (GO:0033599)2.31699395
170regulation of translational termination (GO:0006449)2.31295870
171vesicle coating (GO:0006901)2.29835662
172mesodermal cell differentiation (GO:0048333)2.29345872
173endodermal cell differentiation (GO:0035987)2.28945619
174DNA packaging (GO:0006323)2.28775880
175desmosome organization (GO:0002934)2.28521022
176protein N-linked glycosylation (GO:0006487)2.27617574
177negative regulation of protein activation cascade (GO:2000258)2.27149141
178endoplasmic reticulum unfolded protein response (GO:0030968)2.26935312
179positive regulation of extracellular matrix organization (GO:1903055)2.26472701
180positive regulation of chromosome segregation (GO:0051984)2.26120469
181hyaluronan metabolic process (GO:0030212)2.24784494
182embryonic process involved in female pregnancy (GO:0060136)2.23911449
183double-strand break repair via nonhomologous end joining (GO:0006303)2.21388365
184non-recombinational repair (GO:0000726)2.21388365
185basement membrane organization (GO:0071711)2.21135219
186negative regulation of DNA repair (GO:0045738)2.19522052

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.92098039
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.28639175
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.64437213
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.98243965
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.81693202
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.09111463
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.91285333
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.32965502
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.29826054
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.06232661
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.75558354
12* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.66836328
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65606602
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56239248
15GATA1_22025678_ChIP-Seq_K562_Human2.49561456
16E2F7_22180533_ChIP-Seq_HELA_Human2.15046822
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.11859345
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.11280042
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04617939
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.03942776
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02328350
22CLOCK_20551151_ChIP-Seq_293T_Human1.97352921
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.93986476
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93598393
25NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93401999
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91942387
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91188001
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84187110
29ZFX_18555785_ChIP-Seq_MESCs_Mouse1.81705414
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81554121
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.76200511
32PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74731607
33* DCP1A_22483619_ChIP-Seq_HELA_Human1.72895579
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72018277
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.70996784
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68243553
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67269475
38AR_21909140_ChIP-Seq_LNCAP_Human1.65803345
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.65639604
40* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64854297
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64534927
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60417436
43TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.55183955
44* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54231055
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54070232
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51446172
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49632745
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48050458
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46859510
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44936933
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41393439
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38334047
53* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38289228
54* IRF8_27001747_Chip-Seq_BMDM_Mouse1.37115634
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35554002
56GATA4_25053715_ChIP-Seq_YYC3_Human1.30063909
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29940001
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29582543
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27760134
60TFEB_21752829_ChIP-Seq_HELA_Human1.26638138
61ZNF263_19887448_ChIP-Seq_K562_Human1.25743895
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25108714
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25092102
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24993104
65SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24674771
66* XRN2_22483619_ChIP-Seq_HELA_Human1.22996772
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22289968
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21064621
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20220352
70TTF2_22483619_ChIP-Seq_HELA_Human1.19813182
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19257342
72* HNF4A_19822575_ChIP-Seq_HepG2_Human1.19177986
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18862057
74BRD4_25478319_ChIP-Seq_HGPS_Human1.18500301
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17677850
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17264808
77* GABP_19822575_ChIP-Seq_HepG2_Human1.13560107
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13488852
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13426554
80* FOXA2_19822575_ChIP-Seq_HepG2_Human1.12698063
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10707981
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.09670349
83* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09310796
84EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08742733
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06062751
86FOXM1_23109430_ChIP-Seq_U2OS_Human1.05839695
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05492782
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05479499
89* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05127055
90TRIM28_21343339_ChIP-Seq_HEK293_Human1.03636160
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02801326
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01824803
93* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01641564
94* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01497727
95* GATA6_25053715_ChIP-Seq_YYC3_Human1.01326479
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01242357
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00326075
98CHD1_26751641_Chip-Seq_LNCaP_Human0.99862183
99RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99390608
100NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99318798
101PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99167138
102UBF1/2_26484160_Chip-Seq_HMECs_Human0.98753626
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98243851
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97629551
105HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96925407
106* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96731787
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96249852
108P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95020346
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.94876978
110* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92878213
111RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91428314
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84842998
113* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84280984
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81587181
115* ATF3_27146783_Chip-Seq_COLON_Human0.81489556
116SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81170111
117GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80419387
118VDR_21846776_ChIP-Seq_THP-1_Human0.80388384
119MYC_22102868_ChIP-Seq_BL_Human0.79583963
120CDX2_20551321_ChIP-Seq_CACO-2_Human0.79240161
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77534351
122* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77104694
123MAF_26560356_Chip-Seq_TH1_Human0.75677117
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75153220
125* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74835049
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.74231652
127CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74078816
128RACK7_27058665_Chip-Seq_MCF-7_Human0.72971901
129PU_27001747_Chip-Seq_BMDM_Mouse0.72477364
130MYB_26560356_Chip-Seq_TH1_Human0.72387100
131SCL_19346495_ChIP-Seq_HPC-7_Human0.71602164
132CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71583636
133SPI1_23547873_ChIP-Seq_NB4_Human0.71254386
134* RARA_24833708_ChIP-Seq_LIVER_Mouse0.70795312
135SOX2_20726797_ChIP-Seq_SW620_Human0.70641989
136* FOXO3_23340844_ChIP-Seq_DLD1_Human0.70174097
137TCF7_22412390_ChIP-Seq_EML_Mouse0.68632122
138RUNX1_22412390_ChIP-Seq_EML_Mouse0.68526571
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68344556
140SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68081736
141VDR_24763502_ChIP-Seq_THP-1_Human0.67515740
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67424171
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.65910795
144FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.65224776
145PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64673260
146CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.64453047
147LXR_22292898_ChIP-Seq_THP-1_Human0.63803273
148SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.62491858
149SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.62491858
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.61885198
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.61285971
152FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.58972116
153PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.58437585
154* RARB_24833708_ChIP-Seq_LIVER_Mouse0.58424792
155PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.58120490
156* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.58052527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.65421122
2MP0002139_abnormal_hepatobiliary_system6.45731628
3MP0005085_abnormal_gallbladder_physiolo4.86855008
4MP0005365_abnormal_bile_salt4.76476633
5MP0008875_abnormal_xenobiotic_pharmacok4.11916595
6MP0003252_abnormal_bile_duct3.44661414
7MP0009840_abnormal_foam_cell3.13529381
8MP0003806_abnormal_nucleotide_metabolis3.11988636
9MP0010329_abnormal_lipoprotein_level2.89764701
10MP0002877_abnormal_melanocyte_morpholog2.73548291
11MP0003191_abnormal_cellular_cholesterol2.65327784
12MP0003950_abnormal_plasma_membrane2.53597347
13MP0003111_abnormal_nucleus_morphology2.44623909
14MP0004272_abnormal_basement_membrane2.36575935
15MP0001666_abnormal_nutrient_absorption2.36360591
16MP0005332_abnormal_amino_acid2.31342264
17MP0002138_abnormal_hepatobiliary_system2.25910966
18MP0010094_abnormal_chromosome_stability2.17803684
19MP0005083_abnormal_biliary_tract2.12818718
20MP0003705_abnormal_hypodermis_morpholog2.08691842
21MP0004957_abnormal_blastocyst_morpholog2.03226088
22MP0004019_abnormal_vitamin_homeostasis2.00724672
23MP0000609_abnormal_liver_physiology1.98347454
24MP0003693_abnormal_embryo_hatching1.95234713
25MP0003195_calcinosis1.92993055
26MP0008007_abnormal_cellular_replicative1.85057320
27MP0005257_abnormal_intraocular_pressure1.74932144
28MP0003077_abnormal_cell_cycle1.74225508
29MP0010234_abnormal_vibrissa_follicle1.70631470
30MP0005319_abnormal_enzyme/_coenzyme1.65800095
31MP0002118_abnormal_lipid_homeostasis1.64927485
32MP0003941_abnormal_skin_development1.58609779
33MP0008932_abnormal_embryonic_tissue1.57581179
34MP0003436_decreased_susceptibility_to1.56523560
35MP0001730_embryonic_growth_arrest1.43050424
36MP0009643_abnormal_urine_homeostasis1.41153315
37MP0003186_abnormal_redox_activity1.39245860
38MP0009697_abnormal_copulation1.38452293
39MP0005623_abnormal_meninges_morphology1.33890802
40MP0005584_abnormal_enzyme/coenzyme_acti1.26768505
41MP0000598_abnormal_liver_morphology1.25744515
42MP0005409_darkened_coat_color1.25235364
43MP0000350_abnormal_cell_proliferation1.24088594
44MP0002796_impaired_skin_barrier1.23216811
45MP0005058_abnormal_lysosome_morphology1.22910046
46MP0005464_abnormal_platelet_physiology1.22038885
47MP0008057_abnormal_DNA_replication1.20564812
48MP0001764_abnormal_homeostasis1.20015510
49MP0004264_abnormal_extraembryonic_tissu1.18301582
50MP0002254_reproductive_system_inflammat1.15566967
51MP0003656_abnormal_erythrocyte_physiolo1.13622958
52MP0010352_gastrointestinal_tract_polyps1.13580083
53MP0004808_abnormal_hematopoietic_stem1.11942156
54MP0001672_abnormal_embryogenesis/_devel1.11147125
55MP0005380_embryogenesis_phenotype1.11147125
56MP0003868_abnormal_feces_composition1.11060078
57MP0002086_abnormal_extraembryonic_tissu1.10659004
58MP0009764_decreased_sensitivity_to1.10333153
59MP0008469_abnormal_protein_level1.09573870
60MP0008260_abnormal_autophagy1.09269639
61MP0001835_abnormal_antigen_presentation1.08536216
62MP0004782_abnormal_surfactant_physiolog1.06759462
63MP0002080_prenatal_lethality1.06754462
64MP0003300_gastrointestinal_ulcer1.06731489
65MP0008058_abnormal_DNA_repair1.06384021
66MP0000467_abnormal_esophagus_morphology1.05885435
67MP0003091_abnormal_cell_migration1.05751625
68MP0001697_abnormal_embryo_size1.04131775
69MP0003984_embryonic_growth_retardation1.03586088
70MP0005621_abnormal_cell_physiology1.03539197
71MP0000858_altered_metastatic_potential1.02490681
72MP0001958_emphysema0.99526460
73MP0009763_increased_sensitivity_to0.99483282
74MP0003718_maternal_effect0.98007759
75MP0002088_abnormal_embryonic_growth/wei0.97345073
76MP0009780_abnormal_chondrocyte_physiolo0.96133883
77MP0010030_abnormal_orbit_morphology0.96117017
78MP0004947_skin_inflammation0.95330869
79MP0000604_amyloidosis0.93085247
80MP0001849_ear_inflammation0.92652835
81MP0005636_abnormal_mineral_homeostasis0.91762447
82MP0003303_peritoneal_inflammation0.91330071
83MP0003453_abnormal_keratinocyte_physiol0.89414753
84MP0005164_abnormal_response_to0.89278428
85MP0002896_abnormal_bone_mineralization0.88555995
86MP0003943_abnormal_hepatobiliary_system0.88109787
87MP0003279_aneurysm0.87877142
88MP0000762_abnormal_tongue_morphology0.87122593
89MP0002060_abnormal_skin_morphology0.86936124
90MP0002419_abnormal_innate_immunity0.85931385
91MP0004233_abnormal_muscle_weight0.85524341
92MP0002136_abnormal_kidney_physiology0.85105750
93MP0005384_cellular_phenotype0.85004885
94MP0005084_abnormal_gallbladder_morpholo0.84767510
95MP0006054_spinal_hemorrhage0.84693989
96MP0002166_altered_tumor_susceptibility0.82658784
97MP0005023_abnormal_wound_healing0.81243529
98MP0001845_abnormal_inflammatory_respons0.80909234
99MP0001853_heart_inflammation0.80320889
100MP0004197_abnormal_fetal_growth/weight/0.80238947
101MP0005197_abnormal_uvea_morphology0.80051121
102MP0009785_altered_susceptibility_to0.79262665
103MP0002084_abnormal_developmental_patter0.79029268
104MP0003566_abnormal_cell_adhesion0.78182770
105MP0003011_delayed_dark_adaptation0.77973871
106MP0005025_abnormal_response_to0.77269133
107MP0005165_increased_susceptibility_to0.77234127
108MP0009642_abnormal_blood_homeostasis0.76558031
109MP0000627_abnormal_mammary_gland0.76313821
110MP0000358_abnormal_cell_content/0.75906862
111MP0000537_abnormal_urethra_morphology0.75812642
112MP0005451_abnormal_body_composition0.75732511
113MP0000003_abnormal_adipose_tissue0.75628292
114MP0002085_abnormal_embryonic_tissue0.75511072
115MP0003315_abnormal_perineum_morphology0.75472708
116MP0000685_abnormal_immune_system0.74962415
117MP0005395_other_phenotype0.74215899
118MP0005408_hypopigmentation0.74200952
119MP0001873_stomach_inflammation0.74003981
120MP0005220_abnormal_exocrine_pancreas0.73944694
121MP0005647_abnormal_sex_gland0.73162787
122MP0001216_abnormal_epidermal_layer0.72580469
123MP0000767_abnormal_smooth_muscle0.72057483
124MP0001756_abnormal_urination0.71954486
125MP0003724_increased_susceptibility_to0.71572146
126MP0001533_abnormal_skeleton_physiology0.71391166
127MP0005501_abnormal_skin_physiology0.71189884
128MP0009053_abnormal_anal_canal0.70542760
129MP0005397_hematopoietic_system_phenotyp0.69635537
130MP0001545_abnormal_hematopoietic_system0.69635537
131MP0002928_abnormal_bile_duct0.68188196
132MP0005275_abnormal_skin_tensile0.66858841
133MP0008438_abnormal_cutaneous_collagen0.65987117
134MP0009765_abnormal_xenobiotic_induced0.64890267
135MP0010155_abnormal_intestine_physiology0.64323896
136MP0010307_abnormal_tumor_latency0.63914310
137MP0005376_homeostasis/metabolism_phenot0.62850486
138MP0001243_abnormal_dermal_layer0.61742105
139MP0001915_intracranial_hemorrhage0.61013358
140MP0002396_abnormal_hematopoietic_system0.59524187
141MP0003172_abnormal_lysosome_physiology0.58491749
142MP0000377_abnormal_hair_follicle0.58390729
143MP0010368_abnormal_lymphatic_system0.57334076
144MP0008873_increased_physiological_sensi0.56553082
145MP0005076_abnormal_cell_differentiation0.56309438
146MP0005334_abnormal_fat_pad0.55842197
147MP0005666_abnormal_adipose_tissue0.55657845
148MP0001881_abnormal_mammary_gland0.54730401
149MP0009931_abnormal_skin_appearance0.53722388
150MP0006082_CNS_inflammation0.52951901
151MP0002971_abnormal_brown_adipose0.52088452
152MP0009384_cardiac_valve_regurgitation0.51335623
153MP0003075_altered_response_to0.51241556
154MP0004185_abnormal_adipocyte_glucose0.50521831
155MP0002135_abnormal_kidney_morphology0.50031808

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.15261976
2Deep venous thrombosis (HP:0002625)6.13215889
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.74330133
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.73910393
5Hypobetalipoproteinemia (HP:0003563)5.42974838
6Xanthomatosis (HP:0000991)5.38648518
7Prolonged partial thromboplastin time (HP:0003645)4.99518810
8Complement deficiency (HP:0004431)4.68304587
9Premature rupture of membranes (HP:0001788)4.64240234
10Protrusio acetabuli (HP:0003179)4.50071960
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.40960520
12Abnormality of the common coagulation pathway (HP:0010990)4.11816969
13Hyperlipoproteinemia (HP:0010980)4.09517385
14Joint hemorrhage (HP:0005261)4.01511680
15Hypolipoproteinemia (HP:0010981)4.01507783
16Abnormality of sulfur amino acid metabolism (HP:0004339)3.88242744
17Hyperammonemia (HP:0001987)3.84772655
18Abnormality of pyrimidine metabolism (HP:0004353)3.81858911
19Abnormality of complement system (HP:0005339)3.71537006
20Fat malabsorption (HP:0002630)3.68984462
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.64978824
22Hyperglycinuria (HP:0003108)3.54542777
23Hyperglycinemia (HP:0002154)3.52973736
24Abnormality of the intrinsic pathway (HP:0010989)3.46170899
25Ketosis (HP:0001946)3.46079305
26Myocardial infarction (HP:0001658)3.45490322
27Epidermoid cyst (HP:0200040)3.44182743
28Abnormality of serine family amino acid metabolism (HP:0010894)3.43147257
29Abnormality of glycine metabolism (HP:0010895)3.43147257
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.39199823
31Hypoalphalipoproteinemia (HP:0003233)3.36373389
32Conjugated hyperbilirubinemia (HP:0002908)3.25505209
33Abnormality of nucleobase metabolism (HP:0010932)3.24341732
34Hypoglycemic coma (HP:0001325)3.20190131
35Hypercholesterolemia (HP:0003124)3.19124849
36Vertebral compression fractures (HP:0002953)3.11417265
37Cervical subluxation (HP:0003308)3.07754766
38Recurrent gram-negative bacterial infections (HP:0005420)3.02605643
39Abnormality of fatty-acid metabolism (HP:0004359)3.02272378
40Abnormality of methionine metabolism (HP:0010901)3.02064251
41Systemic lupus erythematosus (HP:0002725)3.02010693
42Abnormality of purine metabolism (HP:0004352)2.95583143
43Ankle contracture (HP:0006466)2.91998623
44Abnormality of carpal bone ossification (HP:0006257)2.87671745
45Hepatocellular carcinoma (HP:0001402)2.87225104
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.83972655
47Flat acetabular roof (HP:0003180)2.82935933
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80083667
49Hyperbilirubinemia (HP:0002904)2.77086576
50Gout (HP:0001997)2.73542066
51Steatorrhea (HP:0002570)2.71804414
52Spontaneous abortion (HP:0005268)2.68586729
53Abnormality of the acetabulum (HP:0003170)2.67586908
54Vascular calcification (HP:0004934)2.62672689
55Gingival bleeding (HP:0000225)2.60643078
56Spastic diplegia (HP:0001264)2.57814759
57Esophageal varix (HP:0002040)2.52154419
58Abnormal delivery (HP:0001787)2.51897274
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.49946842
60Osteolytic defects of the hand bones (HP:0009699)2.49946842
61Abnormality of proline metabolism (HP:0010907)2.49524541
62Hydroxyprolinuria (HP:0003080)2.49524541
63Arterial tortuosity (HP:0005116)2.48327079
64Vascular tortuosity (HP:0004948)2.46647031
65Syringomyelia (HP:0003396)2.44297272
66Spinal cord lesions (HP:0100561)2.44297272
67Delayed CNS myelination (HP:0002188)2.43597991
68Mitral stenosis (HP:0001718)2.43592990
69Abnormal ossification of hand bones (HP:0005921)2.43266714
70Chromsome breakage (HP:0040012)2.42989991
71Abnormality of serum amino acid levels (HP:0003112)2.42819206
72Hypoplasia of the capital femoral epiphysis (HP:0003090)2.41919530
73Cardiovascular calcification (HP:0011915)2.41446556
74Wormian bones (HP:0002645)2.40124201
75Atrophic scars (HP:0001075)2.37584719
76Acanthocytosis (HP:0001927)2.37540371
77Short nail (HP:0001799)2.36934002
78Ketoacidosis (HP:0001993)2.30939134
79Thrombophlebitis (HP:0004418)2.30134223
80Glomerulonephritis (HP:0000099)2.27367671
81Metabolic acidosis (HP:0001942)2.26869020
82Aortic dissection (HP:0002647)2.25228757
83Skin nodule (HP:0200036)2.24433874
84Malnutrition (HP:0004395)2.21903434
85Generalized aminoaciduria (HP:0002909)2.20121772
86Abnormality of dentin (HP:0010299)2.19403326
87Fragile skin (HP:0001030)2.14850352
88Microglossia (HP:0000171)2.14671369
89Delayed closure of the anterior fontanelle (HP:0001476)2.13191085
90Increased mean platelet volume (HP:0011877)2.12703750
91Asymmetry of the thorax (HP:0001555)2.11274075
92Abnormal hand bone ossification (HP:0010660)2.09357771
93Menorrhagia (HP:0000132)2.08866589
94Hypophosphatemic rickets (HP:0004912)2.06909766
95Abnormal foot bone ossification (HP:0010675)2.06435742
96Blue sclerae (HP:0000592)2.05656873
97Dicarboxylic aciduria (HP:0003215)2.05231700
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05231700
99Abnormality of the distal phalanges of the toes (HP:0010182)2.05219870
100Abnormality of transition element cation homeostasis (HP:0011030)2.02642008
101Back pain (HP:0003418)2.01630411
102Amyloidosis (HP:0011034)2.01123065
103Abnormal enzyme/coenzyme activity (HP:0012379)2.00976445
104Small epiphyses (HP:0010585)2.00610244
105Hypochromic microcytic anemia (HP:0004840)2.00412640
106Abnormality of skull ossification (HP:0002703)2.00408573
107Spinal rigidity (HP:0003306)2.00385928
108Decreased skull ossification (HP:0004331)2.00264516
109Abnormality of iron homeostasis (HP:0011031)2.00081621
110Neonatal onset (HP:0003623)1.98749302
111Abnormal platelet volume (HP:0011876)1.96661162
112Acute myeloid leukemia (HP:0004808)1.96374594
113Sensorimotor neuropathy (HP:0007141)1.96078132
114Natal tooth (HP:0000695)1.95385194
115Deviation of the thumb (HP:0009603)1.94447167
116Peritonitis (HP:0002586)1.94296604
117Ankyloglossia (HP:0010296)1.93940642
118Upper motor neuron abnormality (HP:0002127)1.93091973
119Elbow flexion contracture (HP:0002987)1.92600879
120Breech presentation (HP:0001623)1.92457591
121Pancreatitis (HP:0001733)1.92195493
122Axonal loss (HP:0003447)1.90255092
123Proximal tubulopathy (HP:0000114)1.90079931
124Increased purine levels (HP:0004368)1.88585142
125Hyperuricemia (HP:0002149)1.88585142
126Delayed cranial suture closure (HP:0000270)1.88378810
127Irritability (HP:0000737)1.88269214
128Late onset (HP:0003584)1.87738209
129Abnormal cartilage morphology (HP:0002763)1.87453576
130Hemorrhage of the eye (HP:0011885)1.86881836
131Trismus (HP:0000211)1.85354438
132Impaired platelet aggregation (HP:0003540)1.84990675
133Abnormal platelet function (HP:0011869)1.84990675
134Thrombocytosis (HP:0001894)1.84695191
135Nephritis (HP:0000123)1.84514768
136Periodontitis (HP:0000704)1.83873192
137Soft skin (HP:0000977)1.82567659
138Ulnar bowing (HP:0003031)1.82089770
139Abnormality of the vasculature of the conjunctiva (HP:0008054)1.80565722
140Aortic aneurysm (HP:0004942)1.80548495
141Epistaxis (HP:0000421)1.80160236
142Neonatal short-limb short stature (HP:0008921)1.79886252
143Polycythemia (HP:0001901)1.79521635
144Vacuolated lymphocytes (HP:0001922)1.79081935
145Abnormality of the Achilles tendon (HP:0005109)1.78912239
146Abnormality of alkaline phosphatase activity (HP:0004379)1.78889834
147Coxa vara (HP:0002812)1.78345290
148Hypoglycemic seizures (HP:0002173)1.78338538
149Biconcave vertebral bodies (HP:0004586)1.77914084
150Elevated alkaline phosphatase (HP:0003155)1.77810770
151Absent epiphyses (HP:0010577)1.76117165
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76117165
153Lethargy (HP:0001254)1.75520904
154Spondylolisthesis (HP:0003302)1.75225844
155Nonimmune hydrops fetalis (HP:0001790)1.74016377
156Alkalosis (HP:0001948)1.72628614
157Poikilocytosis (HP:0004447)1.72535193
158Vertebral hypoplasia (HP:0008417)1.71202998
159Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.71202998
160Generalized amyotrophy (HP:0003700)1.71186687
161Abnormality of oral frenula (HP:0000190)1.69129163
162Pterygium (HP:0001059)1.68967051
163Spinal cord compression (HP:0002176)1.68299476
164Orthostatic hypotension (HP:0001278)1.66727750
165Abnormality of the umbilical cord (HP:0010881)1.66468156
166Capillary hemangiomas (HP:0005306)1.66441414
167Rough bone trabeculation (HP:0100670)1.64628520
168Proximal placement of thumb (HP:0009623)1.62985952
169Advanced eruption of teeth (HP:0006288)1.62520710
170Entropion (HP:0000621)1.58244613
171Achilles tendon contracture (HP:0001771)1.57940175
172Right ventricular cardiomyopathy (HP:0011663)1.57900147
173Joint laxity (HP:0001388)1.57806481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.63392739
2BCKDK3.89651248
3BUB12.82383449
4TAOK32.71364151
5MST1R2.65436415
6FLT32.61287719
7FGFR42.60858188
8SIK12.48957276
9TRIB32.38820468
10TYK22.21876565
11PKN22.20674265
12MAP3K142.05174156
13SMG11.93055306
14TBK11.91543454
15SRPK11.78308359
16PTK61.71046189
17EIF2AK31.67699254
18MAP3K31.60789775
19MAP2K31.58228701
20NEK91.57964806
21LATS11.52798799
22ACVR1B1.51653122
23RPS6KA41.50727376
24VRK21.46868665
25CDK61.41532203
26PIK3CG1.41074889
27ICK1.40426440
28CDK71.39734589
29STK101.37994599
30NME21.37765959
31MAPK111.35585077
32FRK1.34724325
33MAP3K101.32250605
34CSF1R1.32165463
35STK31.31515216
36LRRK21.30430302
37KIT1.29176498
38ERBB41.27866917
39CDK81.27455651
40SCYL21.26612144
41LATS21.23147264
42MET1.22503048
43BRSK21.21361760
44RPS6KB21.20695972
45NEK21.20033280
46PIM21.16002882
47PAK21.15225955
48PLK31.14351149
49NEK11.14020497
50CHEK21.11200890
51EEF2K1.10699865
52TSSK61.09599459
53GRK61.09416525
54ABL21.03531340
55TGFBR21.02734711
56JAK31.02038446
57MOS1.00282927
58MAP3K80.99675932
59BLK0.98185361
60BRSK10.97949183
61TESK10.95313222
62PLK10.94716283
63CDK40.93953882
64PAK40.89876370
65ZAP700.87415161
66BMX0.87221766
67MAP3K110.86706819
68JAK20.85878342
69WEE10.85184954
70MAP4K10.84406092
71PIM10.83674027
72RIPK10.83405793
73CLK10.82916963
74PLK40.81802774
75KDR0.81229507
76DYRK1B0.81132477
77JAK10.80757694
78BRD40.78863859
79CDK120.78488209
80EIF2AK20.77959821
81CHEK10.77333003
82MELK0.77330969
83IRAK30.75520755
84STK38L0.73768738
85EIF2AK10.73728981
86CSK0.72469959
87TTK0.72071177
88IKBKE0.70611366
89MATK0.68008398
90ARAF0.67721043
91BTK0.67139443
92TESK20.64225604
93EPHB10.63808911
94TGFBR10.62014643
95MKNK10.61024167
96CDK90.59980479
97IKBKB0.59558172
98LIMK10.59418623
99CHUK0.59162277
100MAPKAPK30.58952029
101PDK30.56410612
102PDK40.56410612
103AURKA0.55232784
104PRKAA20.54664807
105YES10.54557742
106LMTK20.52750279
107PRKG20.51333925
108PTK20.51288089
109STK40.49964581
110MTOR0.49483684
111MAPK40.49181605
112MYLK0.48856053
113CAMK1D0.48162200
114TTN0.47309041
115MST40.45859687
116FGFR10.45663233
117MAP3K60.44647270
118EGFR0.44400385
119ATM0.44152048
120EPHB20.43868296
121NTRK10.43707329
122MAPKAPK20.43293099
123MAP3K50.42926776
124RAF10.42624996
125TRIM280.42319918
126MAP3K20.41814804
127TRPM70.41382763
128CDC70.40965430
129STK160.40378808
130FGFR30.39910619
131PDGFRA0.39727983
132EPHA20.38672478
133PDGFRB0.38172288
134PAK10.37948277
135AURKB0.37912501
136PBK0.37744703
137SIK30.37716046
138GSK3A0.36673156
139ABL10.36319430
140TEC0.35877811
141ITK0.34813644
142MAP2K20.34571350
143ATR0.33998122
144IRAK40.33867141
145FER0.33865444

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.03623333
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.43358243
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.20210834
4Nitrogen metabolism_Homo sapiens_hsa009103.13870262
5Arginine biosynthesis_Homo sapiens_hsa002202.86158130
6Complement and coagulation cascades_Homo sapiens_hsa046102.62363021
7Tryptophan metabolism_Homo sapiens_hsa003802.52722711
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51102645
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46534940
10Fatty acid degradation_Homo sapiens_hsa000712.42652528
11Mismatch repair_Homo sapiens_hsa034302.33793870
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33319011
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.23296545
14Caffeine metabolism_Homo sapiens_hsa002322.16591038
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14854069
16Base excision repair_Homo sapiens_hsa034102.04243490
17Staphylococcus aureus infection_Homo sapiens_hsa051501.99351246
18Peroxisome_Homo sapiens_hsa041461.96435645
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.89879397
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.89878164
21Histidine metabolism_Homo sapiens_hsa003401.87431717
22Selenocompound metabolism_Homo sapiens_hsa004501.84682928
23Cell cycle_Homo sapiens_hsa041101.82310792
24PPAR signaling pathway_Homo sapiens_hsa033201.77554559
25Nucleotide excision repair_Homo sapiens_hsa034201.77111626
26Chemical carcinogenesis_Homo sapiens_hsa052041.75990795
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71250160
28Butanoate metabolism_Homo sapiens_hsa006501.70779190
29Propanoate metabolism_Homo sapiens_hsa006401.69053133
30beta-Alanine metabolism_Homo sapiens_hsa004101.62277294
31Non-homologous end-joining_Homo sapiens_hsa034501.59340837
32Fatty acid metabolism_Homo sapiens_hsa012121.58575598
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.56080644
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54106766
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52788533
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50675090
37Retinol metabolism_Homo sapiens_hsa008301.49441054
38Sulfur metabolism_Homo sapiens_hsa009201.44657629
39Folate biosynthesis_Homo sapiens_hsa007901.44411322
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43473860
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.40948789
42Phenylalanine metabolism_Homo sapiens_hsa003601.37598760
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.35686462
44Starch and sucrose metabolism_Homo sapiens_hsa005001.34281975
45Bile secretion_Homo sapiens_hsa049761.32729346
46Pyrimidine metabolism_Homo sapiens_hsa002401.32199525
47One carbon pool by folate_Homo sapiens_hsa006701.31346127
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31070915
49Biosynthesis of amino acids_Homo sapiens_hsa012301.29908357
50Fat digestion and absorption_Homo sapiens_hsa049751.27102906
51RNA transport_Homo sapiens_hsa030131.23161293
52Pyruvate metabolism_Homo sapiens_hsa006201.22726757
53ECM-receptor interaction_Homo sapiens_hsa045121.21475585
54Carbon metabolism_Homo sapiens_hsa012001.20007926
55ABC transporters_Homo sapiens_hsa020101.19557001
56Vitamin digestion and absorption_Homo sapiens_hsa049771.17477398
57Tyrosine metabolism_Homo sapiens_hsa003501.08653972
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08410175
59Chronic myeloid leukemia_Homo sapiens_hsa052201.08108591
60p53 signaling pathway_Homo sapiens_hsa041151.04718499
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04342021
62Proteasome_Homo sapiens_hsa030501.01177634
63Thyroid cancer_Homo sapiens_hsa052161.00790339
64Sulfur relay system_Homo sapiens_hsa041220.97873236
65Spliceosome_Homo sapiens_hsa030400.97829281
66Pancreatic cancer_Homo sapiens_hsa052120.95383831
67Glutathione metabolism_Homo sapiens_hsa004800.92802999
68Steroid biosynthesis_Homo sapiens_hsa001000.90974806
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90898985
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89841470
71Pentose phosphate pathway_Homo sapiens_hsa000300.89464584
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89297789
73Vitamin B6 metabolism_Homo sapiens_hsa007500.88557390
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88192935
75Adherens junction_Homo sapiens_hsa045200.88020860
76Lysine degradation_Homo sapiens_hsa003100.87658423
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84085674
78Fanconi anemia pathway_Homo sapiens_hsa034600.84046115
79Arginine and proline metabolism_Homo sapiens_hsa003300.83994867
80Focal adhesion_Homo sapiens_hsa045100.83813096
81MicroRNAs in cancer_Homo sapiens_hsa052060.83800925
82Fatty acid elongation_Homo sapiens_hsa000620.83585501
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82795446
84Proteoglycans in cancer_Homo sapiens_hsa052050.81960145
85mRNA surveillance pathway_Homo sapiens_hsa030150.79763620
86Homologous recombination_Homo sapiens_hsa034400.76006387
87Amoebiasis_Homo sapiens_hsa051460.73422098
88Shigellosis_Homo sapiens_hsa051310.72455898
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71327331
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.71306931
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68967322
92Glycerolipid metabolism_Homo sapiens_hsa005610.68664759
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62388018
94Sphingolipid metabolism_Homo sapiens_hsa006000.55842918
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53337612
96Galactose metabolism_Homo sapiens_hsa000520.49927971
97Renin-angiotensin system_Homo sapiens_hsa046140.48662338
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48392575
99Fructose and mannose metabolism_Homo sapiens_hsa000510.47513125
100Prostate cancer_Homo sapiens_hsa052150.44513055
101TGF-beta signaling pathway_Homo sapiens_hsa043500.44443233
102Acute myeloid leukemia_Homo sapiens_hsa052210.44132898
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44100328
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43400116
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43252036
106Non-small cell lung cancer_Homo sapiens_hsa052230.43152285
107Legionellosis_Homo sapiens_hsa051340.42237234
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40401401
109Purine metabolism_Homo sapiens_hsa002300.40154209
110Metabolic pathways_Homo sapiens_hsa011000.36095278
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.35983957
112Fatty acid biosynthesis_Homo sapiens_hsa000610.35858511
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33592624
114Insulin resistance_Homo sapiens_hsa049310.30797308
115Lysosome_Homo sapiens_hsa041420.28342871
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.26555247
117Prion diseases_Homo sapiens_hsa050200.15657205
118Antigen processing and presentation_Homo sapiens_hsa046120.15449168
119Bladder cancer_Homo sapiens_hsa052190.14655474
120Mineral absorption_Homo sapiens_hsa049780.13728373
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11902206
122N-Glycan biosynthesis_Homo sapiens_hsa005100.11133339
123Pertussis_Homo sapiens_hsa051330.10998696
124Hepatitis C_Homo sapiens_hsa051600.08815887
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08520116
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.06712437
127Other glycan degradation_Homo sapiens_hsa005110.05669093
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.04023700
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.03135020
130Linoleic acid metabolism_Homo sapiens_hsa005910.02472080
131Leishmaniasis_Homo sapiens_hsa051400.02099556
132AMPK signaling pathway_Homo sapiens_hsa041520.01420281
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00645491
134Small cell lung cancer_Homo sapiens_hsa052220.00047667
135Apoptosis_Homo sapiens_hsa04210-0.0342299
136DNA replication_Homo sapiens_hsa03030-0.0295433
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0046460
138Influenza A_Homo sapiens_hsa05164-0.0015052

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