ERMAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cell surface transmembrane protein that may act as an erythroid cell receptor, possibly as a mediator of cell adhesion. Polymorphisms in this gene are responsible for the Scianna/Radin blood group system. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1porphyrin-containing compound metabolic process (GO:0006778)9.59700623
2heme metabolic process (GO:0042168)9.47718605
3oxygen transport (GO:0015671)9.16043329
4erythrocyte maturation (GO:0043249)8.95886256
5erythrocyte development (GO:0048821)7.05059621
6response to methylmercury (GO:0051597)6.97182530
7negative regulation of erythrocyte differentiation (GO:0045647)6.68422559
8one-carbon compound transport (GO:0019755)6.34236520
9tetrapyrrole metabolic process (GO:0033013)6.23091408
10hemoglobin metabolic process (GO:0020027)6.02148308
11response to lead ion (GO:0010288)5.91481451
12response to insecticide (GO:0017085)5.56927817
13pigment biosynthetic process (GO:0046148)5.45351689
14erythrocyte differentiation (GO:0030218)5.06586751
15myeloid cell development (GO:0061515)4.73757301
16pigment metabolic process (GO:0042440)4.57349188
17iron ion import (GO:0097286)4.36923435
18gas transport (GO:0015669)4.34213239
19embryonic hemopoiesis (GO:0035162)4.12836593
20regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.12433731
21neutrophil activation involved in immune response (GO:0002283)4.12182222
22bicarbonate transport (GO:0015701)4.09241825
23regulation of DNA endoreduplication (GO:0032875)4.09130905
24import into cell (GO:0098657)4.07093434
25DNA replication initiation (GO:0006270)4.06800077
26kinetochore organization (GO:0051383)4.04806839
27DNA replication checkpoint (GO:0000076)3.83119299
28granulocyte differentiation (GO:0030851)3.72132208
29kinetochore assembly (GO:0051382)3.68920843
30telomere maintenance via semi-conservative replication (GO:0032201)3.65634635
31regulation of response to osmotic stress (GO:0047484)3.65314867
32platelet formation (GO:0030220)3.60767437
33CENP-A containing nucleosome assembly (GO:0034080)3.59283025
34response to peptidoglycan (GO:0032494)3.57666625
35positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.56753551
36regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.55201416
37cellular response to thyroid hormone stimulus (GO:0097067)3.51280966
38positive regulation of gamma-delta T cell activation (GO:0046645)3.44038880
39DNA strand elongation involved in DNA replication (GO:0006271)3.41119091
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40513697
41chromatin remodeling at centromere (GO:0031055)3.35154354
42response to arsenic-containing substance (GO:0046685)3.32018893
43protein autoprocessing (GO:0016540)3.30089390
44DNA strand elongation (GO:0022616)3.29072482
45mannose metabolic process (GO:0006013)3.27265332
46cellular response to arsenic-containing substance (GO:0071243)3.26095528
47microtubule depolymerization (GO:0007019)3.25993143
48cofactor biosynthetic process (GO:0051188)3.25805799
49meiotic chromosome segregation (GO:0045132)3.23469783
50protein-cofactor linkage (GO:0018065)3.10448947
51DNA replication-independent nucleosome organization (GO:0034724)3.05959218
52DNA replication-independent nucleosome assembly (GO:0006336)3.05959218
53regulation of platelet aggregation (GO:0090330)3.04905436
54glycine transport (GO:0015816)3.04422834
55response to thyroid hormone (GO:0097066)3.03919963
56positive regulation of insulin receptor signaling pathway (GO:0046628)3.03430925
57regulation of mast cell degranulation (GO:0043304)3.02679186
58mitotic sister chromatid segregation (GO:0000070)3.01185060
59deoxyribonucleotide biosynthetic process (GO:0009263)3.00988429
60DNA unwinding involved in DNA replication (GO:0006268)3.00428025
61protein localization to chromosome, centromeric region (GO:0071459)2.97924779
62telomere maintenance via recombination (GO:0000722)2.97448894
63regulation of histone H3-K9 methylation (GO:0051570)2.96380205
64poly(A)+ mRNA export from nucleus (GO:0016973)2.92608462
65definitive hemopoiesis (GO:0060216)2.90690140
66positive regulation of B cell differentiation (GO:0045579)2.87697179
67DNA strand renaturation (GO:0000733)2.86838312
68positive regulation of fibroblast migration (GO:0010763)2.86458181
69negative regulation of viral entry into host cell (GO:0046597)2.84716367
70very-low-density lipoprotein particle assembly (GO:0034379)2.84270470
71regulation of erythrocyte differentiation (GO:0045646)2.83078991
72nucleosome assembly (GO:0006334)2.82453114
73regulation of granulocyte differentiation (GO:0030852)2.82327853
74positive regulation of erythrocyte differentiation (GO:0045648)2.78377970
753-UTR-mediated mRNA stabilization (GO:0070935)2.76415201
76regulation of mast cell activation involved in immune response (GO:0033006)2.74730199
77proteasome assembly (GO:0043248)2.74012929
78maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.73425779
79mitotic recombination (GO:0006312)2.71061999
80sister chromatid segregation (GO:0000819)2.69867348
81attachment of spindle microtubules to kinetochore (GO:0008608)2.69439902
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69342663
83negative regulation of fatty acid biosynthetic process (GO:0045717)2.68515250
84histone exchange (GO:0043486)2.67598170
85megakaryocyte development (GO:0035855)2.67406054
86granulocyte activation (GO:0036230)2.66065597
87actin filament capping (GO:0051693)2.65484429
88mitotic G2/M transition checkpoint (GO:0044818)2.65267554
89protein-DNA complex assembly (GO:0065004)2.63661237
90negative regulation of protein localization to plasma membrane (GO:1903077)2.63136332
91energy homeostasis (GO:0097009)2.61935277
92DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.61788693
93ribosomal small subunit assembly (GO:0000028)2.61476147
94detection of other organism (GO:0098543)2.61141916
95hydrogen peroxide catabolic process (GO:0042744)2.61059674
96positive regulation of cellular amide metabolic process (GO:0034250)2.58478588
97detection of bacterium (GO:0016045)2.57305668
98neutrophil activation (GO:0042119)2.57076759
99innate immune response in mucosa (GO:0002227)2.57013816
100preassembly of GPI anchor in ER membrane (GO:0016254)2.56837318
101positive regulation of granulocyte differentiation (GO:0030854)2.56756446
102regulation of histone H3-K4 methylation (GO:0051569)2.56690698
103viral transcription (GO:0019083)2.56620312
104chromatin assembly or disassembly (GO:0006333)2.56208620
105negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.56159408
106N-terminal protein amino acid acetylation (GO:0006474)2.55118416
107centriole assembly (GO:0098534)2.53632329
108regulation of exit from mitosis (GO:0007096)2.53512152
109water-soluble vitamin biosynthetic process (GO:0042364)2.52369395
110regulation of RNA export from nucleus (GO:0046831)2.51724445
111telomere maintenance via telomere lengthening (GO:0010833)2.51591629
112iron-sulfur cluster assembly (GO:0016226)2.51103630
113metallo-sulfur cluster assembly (GO:0031163)2.51103630
114defense response to fungus (GO:0050832)2.50097266
115hemopoiesis (GO:0030097)2.50090722
116folic acid-containing compound biosynthetic process (GO:0009396)2.48562166
117mitotic G2 DNA damage checkpoint (GO:0007095)2.47221552
118translational termination (GO:0006415)2.47078254
119DNA synthesis involved in DNA repair (GO:0000731)2.46705330
120protein localization to kinetochore (GO:0034501)2.46491014
121regulation of leukocyte degranulation (GO:0043300)2.45849535
122DNA replication-dependent nucleosome organization (GO:0034723)2.45453752
123DNA replication-dependent nucleosome assembly (GO:0006335)2.45453752
124iron ion homeostasis (GO:0055072)2.45349132
125positive regulation of megakaryocyte differentiation (GO:0045654)2.44554535
126regulation of myeloid leukocyte mediated immunity (GO:0002886)2.43549967
127deoxyribose phosphate biosynthetic process (GO:0046385)2.42837587
1282-deoxyribonucleotide biosynthetic process (GO:0009265)2.42837587
129potassium ion export (GO:0071435)2.42181797
130nucleosome organization (GO:0034728)2.40952371
131N-acetylneuraminate metabolic process (GO:0006054)2.40079911
132antibacterial humoral response (GO:0019731)2.39611226
133negative regulation of DNA-dependent DNA replication (GO:2000104)2.39263131
134regulation of cytokine secretion involved in immune response (GO:0002739)2.39078322
135cellular extravasation (GO:0045123)2.38907220
136DNA double-strand break processing (GO:0000729)2.38904659
137sphingosine metabolic process (GO:0006670)2.38568660
138negative regulation of focal adhesion assembly (GO:0051895)2.38512913
139negative regulation of cell junction assembly (GO:1901889)2.38512913
140negative regulation of adherens junction organization (GO:1903392)2.38512913
141positive regulation of chromosome segregation (GO:0051984)2.37157035
142autophagic vacuole fusion (GO:0000046)2.36910527
143DNA topological change (GO:0006265)2.34063396
144positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.31232811
145leukocyte degranulation (GO:0043299)2.30890099
146hematopoietic stem cell differentiation (GO:0060218)2.28532374
147low-density lipoprotein particle clearance (GO:0034383)2.28468323
148antimicrobial humoral response (GO:0019730)2.28335521
149modulation by virus of host process (GO:0019054)2.27344117
150positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.25380815
151positive regulation of bone remodeling (GO:0046852)2.24982307
152positive regulation of bone resorption (GO:0045780)2.24982307
153regulation of nucleobase-containing compound transport (GO:0032239)2.24843990
154regulation of metalloenzyme activity (GO:0048552)2.22436911
155iron ion transport (GO:0006826)2.22180693
156myeloid cell activation involved in immune response (GO:0002275)2.22128056
157Arp2/3 complex-mediated actin nucleation (GO:0034314)2.21634692
158hepatocyte apoptotic process (GO:0097284)2.21279437
159regulation of natural killer cell differentiation (GO:0032823)2.18368116
160detection of external biotic stimulus (GO:0098581)2.16844656
161mitochondrion degradation (GO:0000422)2.16103619
162protoporphyrinogen IX metabolic process (GO:0046501)17.1680242
163protoporphyrinogen IX biosynthetic process (GO:0006782)16.1789020
164porphyrin-containing compound biosynthetic process (GO:0006779)12.1054499
165heme biosynthetic process (GO:0006783)12.0063096
166tetrapyrrole biosynthetic process (GO:0033014)10.9277645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.67768995
2GATA1_22025678_ChIP-Seq_K562_Human5.55315064
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.54097688
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.30024047
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.18683971
6KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse3.85864563
7* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.77859158
8GATA1_19941827_ChIP-Seq_MEL_Mouse3.59321749
9* GATA1_19941826_ChIP-Seq_K562_Human3.58284347
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.48427657
11SCL_19346495_ChIP-Seq_HPC-7_Human3.47245478
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.03216542
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.87737829
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86245398
15GATA1_22383799_ChIP-Seq_G1ME_Mouse2.56436210
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47536662
17NCOR1_26117541_ChIP-Seq_K562_Human2.34733029
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.33606183
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29481143
20SPI1_23127762_ChIP-Seq_K562_Human2.25087223
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.23674591
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17808902
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17661783
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16644210
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04566411
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.01775968
27SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.99936773
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.97703006
29VDR_24763502_ChIP-Seq_THP-1_Human1.96691989
30* GATA2_19941826_ChIP-Seq_K562_Human1.96385237
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94188619
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88382952
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87527825
34MYC_22102868_ChIP-Seq_BL_Human1.86222334
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86049844
36VDR_23849224_ChIP-Seq_CD4+_Human1.81641750
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80276208
38SPI1_23547873_ChIP-Seq_NB4_Human1.76873790
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.71397182
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71383406
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69656586
42MAF_26560356_Chip-Seq_TH1_Human1.68001045
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67993263
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66955786
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.66086237
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.65287655
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64313166
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.63873566
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62030301
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61683859
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60076892
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59905154
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.56384693
54AR_21909140_ChIP-Seq_LNCAP_Human1.56252084
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56102213
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54312774
57TCF7_22412390_ChIP-Seq_EML_Mouse1.54176064
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51995806
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51862233
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50026123
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49640330
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48131233
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47680790
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.47160801
65FOXP3_21729870_ChIP-Seq_TREG_Human1.47074475
66MYB_26560356_Chip-Seq_TH1_Human1.46495999
67RXR_22158963_ChIP-Seq_LIVER_Mouse1.46468820
68UTX_26944678_Chip-Seq_JUKART_Human1.44011087
69IRF8_21731497_ChIP-ChIP_J774_Mouse1.42700043
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42402426
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41702385
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41262226
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39384220
74ELK1_19687146_ChIP-ChIP_HELA_Human1.37311281
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34610402
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32957896
77MYB_26560356_Chip-Seq_TH2_Human1.31864221
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31291018
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26582835
80KDM2B_26808549_Chip-Seq_DND41_Human1.25624541
81ZNF263_19887448_ChIP-Seq_K562_Human1.24835878
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23875115
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23803534
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23456706
85SOX2_16153702_ChIP-ChIP_HESCs_Human1.23133963
86FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.22606304
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19971234
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.19280150
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18071445
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17998371
91DCP1A_22483619_ChIP-Seq_HELA_Human1.17509914
92IRF1_19129219_ChIP-ChIP_H3396_Human1.16946130
93MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15660532
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14507583
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13574877
96LXR_22158963_ChIP-Seq_LIVER_Mouse1.11265753
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.09374336
98* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09001887
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08817347
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07475655
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06957406
102XRN2_22483619_ChIP-Seq_HELA_Human1.06125786
103* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05250360
104E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04698242
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04595037
106TTF2_22483619_ChIP-Seq_HELA_Human1.03481036
107STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03470654
108* MAF_26560356_Chip-Seq_TH2_Human1.02373963
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01736807
110EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99963066
111SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99355181
112* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98992896
113CIITA_25753668_ChIP-Seq_RAJI_Human0.98020803
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.97918830
115SALL4_22934838_ChIP-ChIP_CD34+_Human0.96799798
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96586288
117VDR_21846776_ChIP-Seq_THP-1_Human0.96553178
118FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95955906
119YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95370317
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94875860
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94808720
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92745201
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91864616
124GATA3_27048872_Chip-Seq_THYMUS_Human0.90659863
125GABP_19822575_ChIP-Seq_HepG2_Human0.90088179
126KDM5A_27292631_Chip-Seq_BREAST_Human0.88836660
127SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88705453
128STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.88251873
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87909368
130PU_27001747_Chip-Seq_BMDM_Mouse0.87229774
131WT1_19549856_ChIP-ChIP_CCG9911_Human0.87061406
132MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86996231
133CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86941297
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86902520
135RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86056408
136YY1_21170310_ChIP-Seq_MESCs_Mouse0.85597823
137NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85366276
138RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85253317
139PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84202094
140MYC_18940864_ChIP-ChIP_HL60_Human0.83598232
141* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81848519
142STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80139554
143GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79333243
144PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78161184
145POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77123078
146GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76529735
147STAT1_20625510_ChIP-Seq_HELA_Human0.74391990
148IGF1R_20145208_ChIP-Seq_DFB_Human0.74135092
149RUNX1_22412390_ChIP-Seq_EML_Mouse0.73986087
150ETS1_22383799_ChIP-Seq_G1ME_Mouse0.71250794
151RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.68439150
152IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.67734231
153CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.67631791
154GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.66369227
155ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.65867137
156EWS_26573619_Chip-Seq_HEK293_Human0.64488796
157TFEB_21752829_ChIP-Seq_HELA_Human0.63695734
158MYB_21317192_ChIP-Seq_ERMYB_Mouse0.63195863
159CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.61832764
160PCGF2_27294783_Chip-Seq_NPCs_Mouse0.59830411
161CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.57884990
162ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.57445186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.39593396
2MP0010094_abnormal_chromosome_stability2.83201669
3MP0008057_abnormal_DNA_replication2.82136194
4MP0003303_peritoneal_inflammation2.59440664
5MP0001545_abnormal_hematopoietic_system2.56898208
6MP0005397_hematopoietic_system_phenotyp2.56898208
7MP0009278_abnormal_bone_marrow2.45642971
8MP0006054_spinal_hemorrhage2.39986195
9MP0005451_abnormal_body_composition2.34920415
10MP0002396_abnormal_hematopoietic_system2.26691204
11MP0003172_abnormal_lysosome_physiology2.19312421
12MP0005083_abnormal_biliary_tract2.15622172
13MP0005636_abnormal_mineral_homeostasis2.01298481
14MP0003656_abnormal_erythrocyte_physiolo11.1338130
15MP0004147_increased_porphyrin_level10.9029559
16MP0003077_abnormal_cell_cycle1.98363929
17MP0003693_abnormal_embryo_hatching1.97800179
18MP0005058_abnormal_lysosome_morphology1.96633913
19MP0002132_abnormal_respiratory_system1.88476885
20MP0001529_abnormal_vocalization1.87544070
21MP0008058_abnormal_DNA_repair1.81651795
22MP0000490_abnormal_crypts_of1.76068424
23MP0003191_abnormal_cellular_cholesterol1.71004153
24MP0002102_abnormal_ear_morphology1.64202064
25MP0003436_decreased_susceptibility_to1.51395432
26MP0002419_abnormal_innate_immunity1.43882083
27MP0004957_abnormal_blastocyst_morpholog1.40572748
28MP0003300_gastrointestinal_ulcer1.40128362
29MP0009785_altered_susceptibility_to1.37972338
30MP0009840_abnormal_foam_cell1.37298506
31MP0008004_abnormal_stomach_pH1.36574521
32MP0002398_abnormal_bone_marrow1.35191644
33MP0002166_altered_tumor_susceptibility1.33688869
34MP0008438_abnormal_cutaneous_collagen1.28963281
35MP0008775_abnormal_heart_ventricle1.25240740
36MP0008872_abnormal_physiological_respon1.20767114
37MP0001835_abnormal_antigen_presentation1.18587070
38MP0001188_hyperpigmentation1.16077785
39MP0006036_abnormal_mitochondrial_physio1.15505895
40MP0003186_abnormal_redox_activity1.14711547
41MP0004947_skin_inflammation1.13735715
42MP0008260_abnormal_autophagy1.13714951
43MP0000343_altered_response_to1.13685453
44MP0002722_abnormal_immune_system1.12185344
45MP0005000_abnormal_immune_tolerance1.11613169
46MP0009333_abnormal_splenocyte_physiolog1.10986260
47MP0006082_CNS_inflammation1.09435381
48MP0000689_abnormal_spleen_morphology1.09205466
49MP0008789_abnormal_olfactory_epithelium1.05499518
50MP0005464_abnormal_platelet_physiology1.04089795
51MP0000609_abnormal_liver_physiology1.03887127
52MP0005076_abnormal_cell_differentiation1.02741670
53MP0003045_fibrosis1.02011735
54MP0002095_abnormal_skin_pigmentation0.99841100
55MP0002429_abnormal_blood_cell0.99840171
56MP0004215_abnormal_myocardial_fiber0.97091592
57MP0005394_taste/olfaction_phenotype0.95528891
58MP0005499_abnormal_olfactory_system0.95528891
59MP0003828_pulmonary_edema0.94805076
60MP0008932_abnormal_embryonic_tissue0.94392920
61MP0000313_abnormal_cell_death0.92684116
62MP0005671_abnormal_response_to0.92480066
63MP0001661_extended_life_span0.92355048
64MP0010307_abnormal_tumor_latency0.89137783
65MP0002139_abnormal_hepatobiliary_system0.88660580
66MP0005164_abnormal_response_to0.88137038
67MP0003705_abnormal_hypodermis_morpholog0.86693998
68MP0002148_abnormal_hypersensitivity_rea0.85508054
69MP0004883_abnormal_blood_vessel0.85306797
70MP0006292_abnormal_olfactory_placode0.84220753
71MP0009931_abnormal_skin_appearance0.83731736
72MP0000858_altered_metastatic_potential0.83661767
73MP0008877_abnormal_DNA_methylation0.83626260
74MP0001790_abnormal_immune_system0.83314957
75MP0005387_immune_system_phenotype0.83314957
76MP0005275_abnormal_skin_tensile0.81514120
77MP0008469_abnormal_protein_level0.81469516
78MP0002723_abnormal_immune_serum0.81333668
79MP0001845_abnormal_inflammatory_respons0.81281034
80MP0002452_abnormal_antigen_presenting0.80851335
81MP0009764_decreased_sensitivity_to0.80332975
82MP0000598_abnormal_liver_morphology0.79694772
83MP0003806_abnormal_nucleotide_metabolis0.78450414
84MP0001533_abnormal_skeleton_physiology0.78149672
85MP0003787_abnormal_imprinting0.77180056
86MP0000703_abnormal_thymus_morphology0.77084910
87MP0005174_abnormal_tail_pigmentation0.76352637
88MP0008770_decreased_survivor_rate0.76040032
89MP0000350_abnormal_cell_proliferation0.74795269
90MP0004808_abnormal_hematopoietic_stem0.73831970
91MP0000685_abnormal_immune_system0.73247729
92MP0005647_abnormal_sex_gland0.72358978
93MP0003763_abnormal_thymus_physiology0.71290155
94MP0002019_abnormal_tumor_incidence0.71168162
95MP0005501_abnormal_skin_physiology0.71006374
96MP0003786_premature_aging0.70153078
97MP0003566_abnormal_cell_adhesion0.69902710
98MP0005409_darkened_coat_color0.69145892
99MP0009643_abnormal_urine_homeostasis0.69028508
100MP0005645_abnormal_hypothalamus_physiol0.68254224
101MP0008995_early_reproductive_senescence0.68116864
102MP0001800_abnormal_humoral_immune0.66324621
103MP0005075_abnormal_melanosome_morpholog0.65534397
104MP0002877_abnormal_melanocyte_morpholog0.65505427
105MP0001905_abnormal_dopamine_level0.65444104
106MP0002006_tumorigenesis0.65269098
107MP0008007_abnormal_cellular_replicative0.65131523
108MP0010155_abnormal_intestine_physiology0.64954679
109MP0004185_abnormal_adipocyte_glucose0.64919839
110MP0001542_abnormal_bone_strength0.64620655
111MP0005621_abnormal_cell_physiology0.64290487
112MP0003795_abnormal_bone_structure0.63765100
113MP0002060_abnormal_skin_morphology0.62885433
114MP0003453_abnormal_keratinocyte_physiol0.62316921
115MP0004142_abnormal_muscle_tone0.62167296
116MP0005319_abnormal_enzyme/_coenzyme0.62119792
117MP0003075_altered_response_to0.57233069
118MP0002736_abnormal_nociception_after0.57069518
119MP0000716_abnormal_immune_system0.56983886
120MP0009765_abnormal_xenobiotic_induced0.56772919
121MP0002735_abnormal_chemical_nociception0.55492559
122MP0001986_abnormal_taste_sensitivity0.54983979
123MP0001663_abnormal_digestive_system0.54908916
124MP0005376_homeostasis/metabolism_phenot0.54544678
125MP0001851_eye_inflammation0.53976060
126MP0002938_white_spotting0.52915632
127MP0003136_yellow_coat_color0.50443504
128MP0000015_abnormal_ear_pigmentation0.49799913
129MP0006035_abnormal_mitochondrial_morpho0.49282245
130MP0000920_abnormal_myelination0.49205678
131MP0005310_abnormal_salivary_gland0.49062046
132MP0000383_abnormal_hair_follicle0.47601804
133MP0003724_increased_susceptibility_to0.47256512
134MP0002138_abnormal_hepatobiliary_system0.46915903
135MP0000749_muscle_degeneration0.46677029
136MP0003121_genomic_imprinting0.45904478
137MP0005171_absent_coat_pigmentation0.45565492
138MP0005025_abnormal_response_to0.45526299
139MP0003718_maternal_effect0.44596326
140MP0002405_respiratory_system_inflammati0.42201509
141MP0000465_gastrointestinal_hemorrhage0.41523927
142MP0002080_prenatal_lethality0.39881864
143MP0002163_abnormal_gland_morphology0.36705355
144MP0001764_abnormal_homeostasis0.36318866
145MP0002009_preneoplasia0.36162549
146MP0009763_increased_sensitivity_to0.35258478
147MP0005379_endocrine/exocrine_gland_phen0.35142819
148MP0001968_abnormal_touch/_nociception0.34806649
149MP0005384_cellular_phenotype0.34401983
150MP0002420_abnormal_adaptive_immunity0.34161224
151MP0001819_abnormal_immune_cell0.33651122
152MP0009697_abnormal_copulation0.33422932
153MP0002229_neurodegeneration0.33414527
154MP0010771_integument_phenotype0.33105543
155MP0005381_digestive/alimentary_phenotyp0.32687405
156MP0001929_abnormal_gametogenesis0.32196491
157MP0003880_abnormal_central_pattern0.32020700

Predicted human phenotypes

RankGene SetZ-score
1Acanthocytosis (HP:0001927)8.58902516
2Reticulocytosis (HP:0001923)7.41403672
3Hypochromic microcytic anemia (HP:0004840)6.66605562
4Abnormal hemoglobin (HP:0011902)5.89930441
5Abnormality of reticulocytes (HP:0004312)5.66161652
6Abnormal number of erythroid precursors (HP:0012131)5.54020568
7Diaphragmatic weakness (HP:0009113)5.52488592
8Osteomalacia (HP:0002749)5.16673652
9Paralysis (HP:0003470)5.12243256
10Abnormality of cells of the erythroid lineage (HP:0012130)5.10887974
11Cholelithiasis (HP:0001081)5.03665699
12Hyperbilirubinemia (HP:0002904)4.79972280
13Abnormal gallbladder morphology (HP:0012437)4.53905541
14Cutaneous photosensitivity (HP:0000992)4.06353046
15Insomnia (HP:0100785)3.95287006
16Hypochromic anemia (HP:0001931)3.64084398
17Birth length less than 3rd percentile (HP:0003561)3.60638473
18Microcytic anemia (HP:0001935)3.60421066
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.58512331
20Petechiae (HP:0000967)3.50430381
21Cholecystitis (HP:0001082)3.43260812
22Abnormal gallbladder physiology (HP:0012438)3.43260812
23Chromsome breakage (HP:0040012)3.37616077
24Abnormality of the gallbladder (HP:0005264)3.06430389
25Increased serum ferritin (HP:0003281)3.06266831
26Prolonged bleeding time (HP:0003010)3.04377228
27Ileus (HP:0002595)2.97176465
28Short middle phalanx of the 5th finger (HP:0004220)2.94772759
29Pallor (HP:0000980)2.90790337
30Nonimmune hydrops fetalis (HP:0001790)2.76113485
31Abnormality of iron homeostasis (HP:0011031)2.69624284
32Duplicated collecting system (HP:0000081)2.66816323
33Polycythemia (HP:0001901)2.60128265
34Spontaneous hematomas (HP:0007420)2.57950475
35Reticulocytopenia (HP:0001896)2.54620284
36Recurrent abscess formation (HP:0002722)2.54566644
37Abnormality of transition element cation homeostasis (HP:0011030)2.46415301
38Hyponatremia (HP:0002902)2.45075238
39Abnormal platelet volume (HP:0011876)2.44572166
40Macrocytic anemia (HP:0001972)2.44431702
41Orthostatic hypotension (HP:0001278)2.40552197
42Increased mean platelet volume (HP:0011877)2.38174013
43Abnormality of liposaccharide metabolism (HP:0010968)2.34972111
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.34972111
45Abnormality of glycolipid metabolism (HP:0010969)2.34972111
46Gingival bleeding (HP:0000225)2.34563002
47Abnormality of the renal collecting system (HP:0004742)2.30924345
48Abnormal platelet function (HP:0011869)2.29858344
49Impaired platelet aggregation (HP:0003540)2.29858344
50Gastrointestinal infarctions (HP:0005244)2.28662049
51Osteomyelitis (HP:0002754)2.25727897
52Abnormality of the fingertips (HP:0001211)2.25599795
53Recurrent bacterial skin infections (HP:0005406)2.21602023
54Abnormality of sodium homeostasis (HP:0010931)2.21004213
55Abnormality of macrophages (HP:0004311)2.20820882
56Toxemia of pregnancy (HP:0100603)2.19568734
57Onycholysis (HP:0001806)2.18391275
58Abnormality of chromosome stability (HP:0003220)2.17616776
59Prostate neoplasm (HP:0100787)2.11674253
60Abnormality of the preputium (HP:0100587)2.11267357
61Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10649351
62Eczematoid dermatitis (HP:0000976)2.10534383
63Confusion (HP:0001289)2.07785746
64Abnormal hair whorl (HP:0010721)2.01971677
65Hematochezia (HP:0002573)2.00064363
66Abnormality of the heme biosynthetic pathway (HP:0010472)14.6346047
67Poikilocytosis (HP:0004447)11.6648886
68Increased cerebral lipofuscin (HP:0011813)1.98507388
69Epistaxis (HP:0000421)1.97221474
70Obstructive lung disease (HP:0006536)1.94016887
71Chronic obstructive pulmonary disease (HP:0006510)1.94016887
72Small intestinal stenosis (HP:0012848)1.93181720
73Duodenal stenosis (HP:0100867)1.93181720
74Recurrent viral infections (HP:0004429)1.92079906
75Granulocytopenia (HP:0001913)1.91583084
76Meckel diverticulum (HP:0002245)1.91210132
77Gastrointestinal dysmotility (HP:0002579)1.91175594
78Pustule (HP:0200039)1.90762154
79Aplasia/Hypoplasia of the uvula (HP:0010293)1.87907623
80Hepatocellular carcinoma (HP:0001402)1.87209520
81Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86982659
82Abnormality of polysaccharide metabolism (HP:0011012)1.86982659
83Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86982659
84Abnormality of the ileum (HP:0001549)1.86777477
85Aplastic anemia (HP:0001915)1.84434615
86Delusions (HP:0000746)1.82546394
87Acute myeloid leukemia (HP:0004808)1.81944868
88Splenomegaly (HP:0001744)1.81431024
89Thrombocytosis (HP:0001894)1.81385221
90Nausea (HP:0002018)1.80945120
91Urticaria (HP:0001025)1.80210624
92Abnormality of dental color (HP:0011073)1.79050534
93Autoimmune thrombocytopenia (HP:0001973)1.78493059
94Recurrent fungal infections (HP:0002841)1.78066074
95Cerebral palsy (HP:0100021)1.77463437
96Autoimmune hemolytic anemia (HP:0001890)1.77168580
97Recurrent skin infections (HP:0001581)1.75955812
98Recurrent gram-negative bacterial infections (HP:0005420)1.75825330
99Cortical visual impairment (HP:0100704)1.75362218
100Fatigue (HP:0012378)1.75239766
101Hypertriglyceridemia (HP:0002155)1.75208756
102Hepatosplenomegaly (HP:0001433)1.74457080
103Increased neuronal autofluorescent lipopigment (HP:0002074)1.73662747
104Ventricular fibrillation (HP:0001663)1.73541646
105Dysostosis multiplex (HP:0000943)1.73235379
106Leukocytosis (HP:0001974)1.72905024
107Hyperthyroidism (HP:0000836)1.72721032
108Hypertensive crisis (HP:0100735)1.71924228
109Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71048236
110Absent epiphyses (HP:0010577)1.71048236
111Myocardial infarction (HP:0001658)1.69753436
112Parakeratosis (HP:0001036)1.68759165
1133-Methylglutaconic aciduria (HP:0003535)1.68380332
114Hypopigmented skin patches (HP:0001053)1.67424448
115Myelodysplasia (HP:0002863)1.67400414
116Renal tubular acidosis (HP:0001947)1.65607473
117Testicular neoplasm (HP:0010788)1.65264426
118Renal tubular dysfunction (HP:0000124)1.64590287
119Breast hypoplasia (HP:0003187)1.63718132
120Albinism (HP:0001022)1.63401395
121Cellulitis (HP:0100658)1.62974398
122Mucopolysacchariduria (HP:0008155)1.62188993
123Urinary glycosaminoglycan excretion (HP:0003541)1.62188993
124Thrombophlebitis (HP:0004418)1.62169415
125Bruising susceptibility (HP:0000978)1.61581199
126Hypoparathyroidism (HP:0000829)1.61152948
127Colitis (HP:0002583)1.60926242
128Inflammation of the large intestine (HP:0002037)1.60385088
129Panhypogammaglobulinemia (HP:0003139)1.59969209
130Abnormal delayed hypersensitivity skin test (HP:0002963)1.59968363
131White forelock (HP:0002211)1.59712340
132Seborrheic dermatitis (HP:0001051)1.58285671
133Acute lymphatic leukemia (HP:0006721)1.57974101
134Menorrhagia (HP:0000132)1.57332394
135Vacuolated lymphocytes (HP:0001922)1.57181928
136Ectopic kidney (HP:0000086)1.56821693
137Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.56138833
138Gastrointestinal inflammation (HP:0004386)1.55762315
139Anorexia (HP:0002039)1.55220133
140Recurrent cutaneous fungal infections (HP:0011370)1.54837474
141Azoospermia (HP:0000027)1.53144221
142Patchy hypopigmentation of hair (HP:0011365)1.52630055
143Irregular epiphyses (HP:0010582)1.51350790
144Upper limb muscle weakness (HP:0003484)1.51053210
145Microvesicular hepatic steatosis (HP:0001414)1.49327623
146Acute necrotizing encephalopathy (HP:0006965)1.49323963
147Purpura (HP:0000979)1.48741298
148Prominent nose (HP:0000448)1.48577155
149Protruding tongue (HP:0010808)1.46237106
150Increased hepatocellular lipid droplets (HP:0006565)1.45754373
151Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.44355640
152Abnormality of the duodenum (HP:0002246)1.44046784
153Mitochondrial inheritance (HP:0001427)1.43860738
154Clubbing of toes (HP:0100760)1.43819833
155Abnormal spermatogenesis (HP:0008669)1.43447260
156Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.42661022
157Pathologic fracture (HP:0002756)1.41187309
158Abnormal blistering of the skin (HP:0008066)1.40822476
159Global brain atrophy (HP:0002283)1.39878623
160Microtia (HP:0008551)1.38878852
161Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.38848798
162Abnormality of DNA repair (HP:0003254)1.38516635
163Increased serum lactate (HP:0002151)1.37965099
164Cafe-au-lait spot (HP:0000957)1.37378917

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK16.61887459
2CDC74.00852189
3PRPF4B3.78911454
4MAP2K33.47145667
5RIPK43.41513290
6TLK13.20876497
7VRK12.79502861
8NME22.76087900
9STK42.66719990
10TAOK12.64212908
11TAOK22.48733502
12ZAK2.32527718
13MAP3K32.21421228
14DYRK32.18138737
15MAPKAPK52.16402362
16STK162.11666336
17TNIK1.87223882
18BRSK11.78116089
19BMX1.72708092
20MAP3K21.72144975
21MAP3K11.69450673
22ERN11.65672618
23BUB11.62112971
24PBK1.61336131
25KSR21.56210665
26TTK1.51932796
27WEE11.50233188
28STK101.46833860
29ZAP701.44859801
30TAOK31.44800430
31RPS6KA51.43384078
32MARK31.42870890
33NEK21.39613947
34HIPK21.35166783
35IRAK31.35139144
36PIM11.31665029
37EIF2AK21.30248220
38CHEK21.27773722
39AURKB1.24693612
40ATR1.24293862
41TBK11.22896476
42AURKA1.21108708
43CLK11.20238371
44TRIB31.19865942
45MKNK21.18428695
46IRAK41.17138419
47SRPK11.16920936
48SCYL21.15803471
49BRSK21.12730480
50STK31.11841544
51CDK191.11124566
52TRPM71.08710342
53GRK71.08651660
54CASK1.07994340
55BTK1.06535170
56CDK121.06496945
57SYK1.04007857
58BMPR21.03487182
59PIM21.03476084
60PLK11.02848650
61CAMK1D1.02566189
62MAPK111.01953866
63RAF11.00926194
64PTK2B0.99441544
65CDK40.99244045
66WNK10.98669765
67MAP2K70.98296550
68ATM0.95833841
69MAP3K140.94163225
70PRKD20.93347513
71MAPKAPK30.93278744
72MAP3K50.91979262
73JAK30.91337762
74CHEK10.91322898
75MAP2K10.90289622
76CDK30.90215272
77TEC0.88510985
78BRD40.88075594
79MKNK10.87442600
80LYN0.86351227
81PRKAA20.85246789
82PINK10.83821176
83FGR0.82317661
84FES0.80709382
85GRK60.77033003
86NME10.76878291
87PKN10.76407392
88EEF2K0.74197320
89MAP3K130.71646170
90JAK20.71144950
91RPS6KC10.70279142
92RPS6KL10.70279142
93MAP3K80.69731292
94KSR10.68183320
95CDK90.68022540
96HCK0.67959853
97SIK10.66671827
98CDK70.66210255
99PIK3CG0.65615984
100TNK20.65210368
101GRK10.64424278
102PLK40.63300971
103GRK50.63243081
104CAMK1G0.61834019
105CSK0.61156939
106SGK30.60794316
107MYLK0.60124497
108MATK0.59637379
109IKBKB0.59585731
110CDK10.57026043
111CDK80.56715691
112BLK0.56616062
113MAP2K20.54914242
114JAK10.54394528
115RET0.52895920
116RPS6KA60.52771446
117MTOR0.52733487
118PDPK10.52705183
119STK240.51920636
120FGFR30.51737384
121CDK20.51553089
122MST40.51120785
123AKT30.51024391
124ERBB20.50852741
125CSNK2A10.50648362
126CSNK1D0.50319375
127SGK20.49623213
128MAP3K70.47848345
129RPS6KB20.46817265
130RPS6KA20.46334510
131CSNK2A20.46296098
132MAP3K60.46113997
133MELK0.44850333
134ADRBK20.43432406
135YES10.43190988
136PRKDC0.43009089
137MAP3K100.42974316
138MAPK70.42950130
139MAPK130.41822837
140CDK60.41163796
141ABL20.41108916
142MAPKAPK20.40845313
143SGK10.40714824
144KIT0.40683165
145ICK0.40678831
146PLK30.40631520
147MAPK120.39589392
148TYK20.39436246
149TGFBR20.39057963
150MAP4K10.38415357
151AKT20.37386205
152MARK20.36320998
153EIF2AK30.35598199
154MAPK140.35390204
155SMG10.35182172
156MAPK30.34970642
157BRAF0.34683984
158CCNB10.34264764
159INSRR0.33945978
160CDK11A0.33127576
161MAP3K110.31760834
162IKBKE0.31592695
163TXK0.30719181
164AKT10.30246353
165DYRK1A0.29914932

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008607.59266826
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.23698102
3DNA replication_Homo sapiens_hsa030304.23175884
4Systemic lupus erythematosus_Homo sapiens_hsa053223.99964128
5Vitamin B6 metabolism_Homo sapiens_hsa007503.72367901
6Ribosome_Homo sapiens_hsa030102.75989314
7Homologous recombination_Homo sapiens_hsa034402.60467042
8Mismatch repair_Homo sapiens_hsa034302.48384224
9Fanconi anemia pathway_Homo sapiens_hsa034602.45553536
10Cell cycle_Homo sapiens_hsa041102.44351643
11Other glycan degradation_Homo sapiens_hsa005112.42830589
12Alcoholism_Homo sapiens_hsa050342.16609509
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14582863
14Nucleotide excision repair_Homo sapiens_hsa034202.10576667
15Acute myeloid leukemia_Homo sapiens_hsa052212.03015673
16Non-homologous end-joining_Homo sapiens_hsa034501.92606676
17Base excision repair_Homo sapiens_hsa034101.91967337
18One carbon pool by folate_Homo sapiens_hsa006701.90814320
19Hematopoietic cell lineage_Homo sapiens_hsa046401.87195997
20Pyrimidine metabolism_Homo sapiens_hsa002401.86929821
21Spliceosome_Homo sapiens_hsa030401.74482750
22RNA polymerase_Homo sapiens_hsa030201.73995526
23Oxidative phosphorylation_Homo sapiens_hsa001901.70141832
24Osteoclast differentiation_Homo sapiens_hsa043801.69861234
25Parkinsons disease_Homo sapiens_hsa050121.68574102
26ABC transporters_Homo sapiens_hsa020101.64546489
27Leishmaniasis_Homo sapiens_hsa051401.59149044
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.54211538
29B cell receptor signaling pathway_Homo sapiens_hsa046621.51997495
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49964540
31Proteasome_Homo sapiens_hsa030501.49684832
32mTOR signaling pathway_Homo sapiens_hsa041501.46325630
33African trypanosomiasis_Homo sapiens_hsa051431.43438371
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38248779
35Sulfur relay system_Homo sapiens_hsa041221.37010718
36Staphylococcus aureus infection_Homo sapiens_hsa051501.32383918
37Platelet activation_Homo sapiens_hsa046111.31439759
38p53 signaling pathway_Homo sapiens_hsa041151.30610193
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30083845
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.26939878
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26713010
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24750305
43Huntingtons disease_Homo sapiens_hsa050161.22953701
44Type II diabetes mellitus_Homo sapiens_hsa049301.22603751
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21302500
46Lysosome_Homo sapiens_hsa041421.20402855
47Tuberculosis_Homo sapiens_hsa051521.15498094
48Viral carcinogenesis_Homo sapiens_hsa052031.14756557
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14084843
50RNA transport_Homo sapiens_hsa030131.13301204
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12755937
52Basal transcription factors_Homo sapiens_hsa030221.10918384
53Malaria_Homo sapiens_hsa051441.09836302
54Collecting duct acid secretion_Homo sapiens_hsa049661.09246951
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.08960103
56Purine metabolism_Homo sapiens_hsa002301.07411460
57SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05348072
58Alzheimers disease_Homo sapiens_hsa050101.03187126
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02176300
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98320881
61RNA degradation_Homo sapiens_hsa030180.97847215
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97088422
63Renal cell carcinoma_Homo sapiens_hsa052110.96855344
64Herpes simplex infection_Homo sapiens_hsa051680.95884848
65FoxO signaling pathway_Homo sapiens_hsa040680.94593401
66Toxoplasmosis_Homo sapiens_hsa051450.92908274
67Legionellosis_Homo sapiens_hsa051340.92772806
68Prolactin signaling pathway_Homo sapiens_hsa049170.91617085
69Ether lipid metabolism_Homo sapiens_hsa005650.88369661
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.87860004
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86421985
72Pertussis_Homo sapiens_hsa051330.84632315
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83594015
74Phagosome_Homo sapiens_hsa041450.82026581
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82015212
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81685269
77Insulin resistance_Homo sapiens_hsa049310.79733680
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79465050
79Linoleic acid metabolism_Homo sapiens_hsa005910.77535973
80HIF-1 signaling pathway_Homo sapiens_hsa040660.77187252
81TNF signaling pathway_Homo sapiens_hsa046680.76683226
82Endometrial cancer_Homo sapiens_hsa052130.76135835
83Thyroid cancer_Homo sapiens_hsa052160.75817003
84Protein export_Homo sapiens_hsa030600.75179886
85Complement and coagulation cascades_Homo sapiens_hsa046100.74877691
86Nitrogen metabolism_Homo sapiens_hsa009100.74085727
87Fructose and mannose metabolism_Homo sapiens_hsa000510.73212590
88Inositol phosphate metabolism_Homo sapiens_hsa005620.71922659
89AMPK signaling pathway_Homo sapiens_hsa041520.70824778
90Insulin signaling pathway_Homo sapiens_hsa049100.70155930
91mRNA surveillance pathway_Homo sapiens_hsa030150.68908413
92Glioma_Homo sapiens_hsa052140.68861154
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68464858
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67138970
95Choline metabolism in cancer_Homo sapiens_hsa052310.65825813
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64613790
97Glutathione metabolism_Homo sapiens_hsa004800.64007614
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63275971
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63244642
100Arachidonic acid metabolism_Homo sapiens_hsa005900.59504257
101Shigellosis_Homo sapiens_hsa051310.57737892
102VEGF signaling pathway_Homo sapiens_hsa043700.57471862
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56420703
104Apoptosis_Homo sapiens_hsa042100.55719608
105Folate biosynthesis_Homo sapiens_hsa007900.54832328
106Metabolic pathways_Homo sapiens_hsa011000.53652790
107T cell receptor signaling pathway_Homo sapiens_hsa046600.53147635
108Amoebiasis_Homo sapiens_hsa051460.53028220
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52746943
110Measles_Homo sapiens_hsa051620.51452614
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50809804
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.49427442
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.49222684
114Chemokine signaling pathway_Homo sapiens_hsa040620.49138315
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.48421932
116Mineral absorption_Homo sapiens_hsa049780.47957227
117Small cell lung cancer_Homo sapiens_hsa052220.45271470
118Sphingolipid metabolism_Homo sapiens_hsa006000.42962458
119Epstein-Barr virus infection_Homo sapiens_hsa051690.42676204
120Hepatitis B_Homo sapiens_hsa051610.42314631
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41416146
122Melanoma_Homo sapiens_hsa052180.41386259
123Selenocompound metabolism_Homo sapiens_hsa004500.39467314
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37902850
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36905439
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.35835038
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35479373
128Asthma_Homo sapiens_hsa053100.34631740
129Sulfur metabolism_Homo sapiens_hsa009200.34067729
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30602497
131Oocyte meiosis_Homo sapiens_hsa041140.30242782
132Steroid biosynthesis_Homo sapiens_hsa001000.29835583
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29722705
134Vitamin digestion and absorption_Homo sapiens_hsa049770.28515600
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27927681
136Bladder cancer_Homo sapiens_hsa052190.27891201
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.26208664
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25965069
139Cardiac muscle contraction_Homo sapiens_hsa042600.22044200
140Non-small cell lung cancer_Homo sapiens_hsa052230.21051051
141Chronic myeloid leukemia_Homo sapiens_hsa052200.20180364
142Pentose phosphate pathway_Homo sapiens_hsa000300.20091009
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16507622
144NF-kappa B signaling pathway_Homo sapiens_hsa040640.16149191
145HTLV-I infection_Homo sapiens_hsa051660.15830913
146Fatty acid elongation_Homo sapiens_hsa000620.12952243
147Autoimmune thyroid disease_Homo sapiens_hsa053200.12392789
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.12026834
149Influenza A_Homo sapiens_hsa051640.10532911
150RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10423090
151Primary immunodeficiency_Homo sapiens_hsa053400.09845423
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09301520
153Regulation of autophagy_Homo sapiens_hsa041400.07876788
154Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.07289933
155Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07173571
156Hepatitis C_Homo sapiens_hsa051600.06821039
157MicroRNAs in cancer_Homo sapiens_hsa052060.06704771
158Prostate cancer_Homo sapiens_hsa052150.06156817
159Arginine and proline metabolism_Homo sapiens_hsa003300.05887633
160Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.05467034
161Pancreatic cancer_Homo sapiens_hsa052120.05282423
162beta-Alanine metabolism_Homo sapiens_hsa004100.04176269
163Dorso-ventral axis formation_Homo sapiens_hsa043200.03456761
164Serotonergic synapse_Homo sapiens_hsa047260.02601091

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