ERMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.46437597
2bundle of His cell to Purkinje myocyte communication (GO:0086069)5.19505502
3regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.84612079
4Golgi transport vesicle coating (GO:0048200)4.67642584
5COPI coating of Golgi vesicle (GO:0048205)4.67642584
6intestinal epithelial cell development (GO:0060576)4.51996742
7glycerophospholipid catabolic process (GO:0046475)4.44403434
8nuclear pore complex assembly (GO:0051292)4.43166774
9monoubiquitinated protein deubiquitination (GO:0035520)4.29923691
10regulation of exit from mitosis (GO:0007096)4.13702994
11mitotic chromosome condensation (GO:0007076)4.10497532
12hemidesmosome assembly (GO:0031581)4.02213261
13mitotic metaphase plate congression (GO:0007080)3.96626451
14regulation of water loss via skin (GO:0033561)3.95096268
15piRNA metabolic process (GO:0034587)3.82851087
16female gamete generation (GO:0007292)3.82706244
17regulation of female gonad development (GO:2000194)3.82142468
18import into cell (GO:0098657)3.76715022
19DNA damage induced protein phosphorylation (GO:0006975)3.76429668
20DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.76183166
21histone H2A monoubiquitination (GO:0035518)3.75811926
22very-low-density lipoprotein particle assembly (GO:0034379)3.72995147
23regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.72965833
24axon ensheathment in central nervous system (GO:0032291)3.72685155
25central nervous system myelination (GO:0022010)3.72685155
26cytoplasmic mRNA processing body assembly (GO:0033962)3.72643774
27iron ion import (GO:0097286)3.65663430
28regulation of cholesterol biosynthetic process (GO:0045540)3.63323424
29pinocytosis (GO:0006907)3.60756517
30DNA damage response, signal transduction resulting in transcription (GO:0042772)3.58565133
31negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.58505074
32regulation of sister chromatid cohesion (GO:0007063)3.57456609
33biotin metabolic process (GO:0006768)3.57278768
34negative regulation of hormone metabolic process (GO:0032351)3.57079685
35negative regulation of hormone biosynthetic process (GO:0032353)3.57079685
36mitotic sister chromatid cohesion (GO:0007064)3.56897711
37nuclear pore organization (GO:0006999)3.54348786
38regulation of meiosis (GO:0040020)3.52605680
39definitive hemopoiesis (GO:0060216)3.51172234
40establishment of skin barrier (GO:0061436)3.45377959
41regulation of cholesterol homeostasis (GO:2000188)3.43210555
42sphingosine metabolic process (GO:0006670)3.39937981
43regulation of spindle organization (GO:0090224)3.39388554
44COPII vesicle coating (GO:0048208)3.38878041
45regulation of hippo signaling (GO:0035330)3.38114364
46regulation of establishment of cell polarity (GO:2000114)3.36470355
47regulation of histone H3-K27 methylation (GO:0061085)3.35430088
48metaphase plate congression (GO:0051310)3.27380902
49pore complex assembly (GO:0046931)3.26163298
50protein K6-linked ubiquitination (GO:0085020)3.25486785
51gap junction assembly (GO:0016264)3.23105067
52branching involved in mammary gland duct morphogenesis (GO:0060444)3.23052776
53microtubule nucleation (GO:0007020)3.22751427
54surfactant homeostasis (GO:0043129)3.22507649
55carnitine transmembrane transport (GO:1902603)3.21175398
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.21081002
57progesterone metabolic process (GO:0042448)3.19496116
58carnitine transport (GO:0015879)3.18382096
59amino-acid betaine transport (GO:0015838)3.18382096
60cytoskeletal anchoring at plasma membrane (GO:0007016)3.17594492
61meiotic cell cycle (GO:0051321)3.17230979
62embryonic retina morphogenesis in camera-type eye (GO:0060059)3.16813225
63epithelial cell differentiation involved in prostate gland development (GO:0060742)3.16078060
64regulation of mitotic spindle organization (GO:0060236)3.15511004
65growth hormone receptor signaling pathway (GO:0060396)3.15135143
66regulation of meiosis I (GO:0060631)3.14657430
67multicellular organismal water homeostasis (GO:0050891)3.10086104
68positive regulation of keratinocyte differentiation (GO:0045618)3.09705956
69plasma lipoprotein particle assembly (GO:0034377)3.07073946
70positive regulation of hormone metabolic process (GO:0032352)3.02556660
71protein retention in ER lumen (GO:0006621)3.01795064
72proline biosynthetic process (GO:0006561)3.01555297
73epithelial cell-cell adhesion (GO:0090136)3.00018382
74retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.00002080
75meiotic chromosome segregation (GO:0045132)2.98578931
76mitotic sister chromatid segregation (GO:0000070)2.94733766
77carnitine shuttle (GO:0006853)2.94257219
78maternal placenta development (GO:0001893)2.94226233
79cellular response to antibiotic (GO:0071236)2.93529763
80protein localization to endosome (GO:0036010)2.92927247
81response to water (GO:0009415)2.92530878
82regulation of establishment or maintenance of cell polarity (GO:0032878)2.91983691
83ER overload response (GO:0006983)2.89727646
84positive regulation of chromosome segregation (GO:0051984)2.89592367
85diol metabolic process (GO:0034311)2.89327241
86embryonic process involved in female pregnancy (GO:0060136)2.88540570
87myelin maintenance (GO:0043217)2.87733883
88C21-steroid hormone metabolic process (GO:0008207)2.85450019
89cellular response to gamma radiation (GO:0071480)2.84673294
90regulation of clathrin-mediated endocytosis (GO:2000369)2.84424088
91oocyte maturation (GO:0001556)2.83830596
92regulation of keratinocyte differentiation (GO:0045616)2.83189294
93type B pancreatic cell development (GO:0003323)2.82796057
94cellular response to growth hormone stimulus (GO:0071378)2.82446761
95sister chromatid cohesion (GO:0007062)2.81827971
96protein-lipid complex assembly (GO:0065005)2.79587262
97female gonad development (GO:0008585)2.79550831
98positive regulation of mitotic sister chromatid separation (GO:1901970)2.78419896
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.78419896
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.78419896
101regulation of meiotic cell cycle (GO:0051445)2.77451716
102activation of Rac GTPase activity (GO:0032863)2.77164780
103hepatocyte apoptotic process (GO:0097284)2.76252962
104histone H2A ubiquitination (GO:0033522)2.75668005
105positive regulation of neurological system process (GO:0031646)2.75565221
106positive regulation of nitric-oxide synthase activity (GO:0051000)2.74125829
107quaternary ammonium group transport (GO:0015697)2.73658249
108regulation of translational fidelity (GO:0006450)2.73625329
109establishment of spindle localization (GO:0051293)2.73145069
110paraxial mesoderm development (GO:0048339)2.72696386
111snRNA transcription (GO:0009301)2.72527984
112positive regulation of epidermal cell differentiation (GO:0045606)2.72461100
113regulation of retinoic acid receptor signaling pathway (GO:0048385)2.70820394
114receptor recycling (GO:0001881)2.69306470
115establishment of chromosome localization (GO:0051303)2.67720494
116positive regulation of hormone biosynthetic process (GO:0046886)2.67640574
117regulation of glucocorticoid metabolic process (GO:0031943)2.67082521
118cell-substrate junction assembly (GO:0007044)2.66384591
119chemical homeostasis within a tissue (GO:0048875)2.65709627
120dicarboxylic acid biosynthetic process (GO:0043650)2.62968656
121regulation of sequestering of triglyceride (GO:0010889)2.62618239
122mammary gland epithelial cell proliferation (GO:0033598)2.62611780
123sister chromatid segregation (GO:0000819)2.61357228
124vesicle coating (GO:0006901)2.61229118
125cell adhesion mediated by integrin (GO:0033627)2.60481941
126regulation of chromatin binding (GO:0035561)2.58917748
127N-terminal protein amino acid acetylation (GO:0006474)2.58582377
128diterpenoid biosynthetic process (GO:0016102)2.58026884
129protein localization to chromosome (GO:0034502)2.57491076
130citrulline biosynthetic process (GO:0019240)2.57438598
131localization within membrane (GO:0051668)2.57048175
132trophectodermal cell differentiation (GO:0001829)2.56093775
133regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.55534351
134negative regulation of meiosis (GO:0045835)2.54023159
135organ growth (GO:0035265)2.53890227
136regulation of cholesterol metabolic process (GO:0090181)2.52174794
137regulation of nucleobase-containing compound transport (GO:0032239)2.51966441
138keratinocyte proliferation (GO:0043616)2.50769132
139microtubule severing (GO:0051013)2.49697716
140negative regulation of protein localization to plasma membrane (GO:1903077)2.49258390
141regulation of transforming growth factor beta2 production (GO:0032909)2.48603157
142mitotic cytokinesis (GO:0000281)2.48482401
143regulation of DNA methylation (GO:0044030)2.48265607
144male meiosis (GO:0007140)2.47637503
145receptor catabolic process (GO:0032801)2.47630303
146negative regulation of neurotransmitter secretion (GO:0046929)2.47454054
147sphingoid metabolic process (GO:0046519)2.47421768
148centrosome localization (GO:0051642)2.47287367
149glycoprotein catabolic process (GO:0006516)2.47190833
150regulation of RNA export from nucleus (GO:0046831)2.46746336
151cellular zinc ion homeostasis (GO:0006882)2.46627279
152membrane protein ectodomain proteolysis (GO:0006509)2.45802343
153tight junction assembly (GO:0070830)2.45780571
154androgen biosynthetic process (GO:0006702)2.44406614
155hypotonic response (GO:0006971)2.43310349
156hepatocyte differentiation (GO:0070365)2.42933280
157ensheathment of neurons (GO:0007272)2.42545857
158axon ensheathment (GO:0008366)2.42545857
159low-density lipoprotein particle clearance (GO:0034383)2.42429177
160cytoskeleton-dependent cytokinesis (GO:0061640)2.41609596
161response to UV-C (GO:0010225)2.41215903
162DNA methylation involved in gamete generation (GO:0043046)2.40848162
163cell-substrate adherens junction assembly (GO:0007045)2.40046491
164focal adhesion assembly (GO:0048041)2.40046491
165water homeostasis (GO:0030104)2.38947469
166Leydig cell differentiation (GO:0033327)2.38367542
167myelination (GO:0042552)2.38188689
168vitamin transmembrane transport (GO:0035461)2.36645952
169protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.35766598
170positive regulation of steroid biosynthetic process (GO:0010893)2.35290766
171negative regulation of circadian rhythm (GO:0042754)2.35208452
172insulin-like growth factor receptor signaling pathway (GO:0048009)2.35148813
173platelet-derived growth factor receptor signaling pathway (GO:0048008)2.34211785
174establishment of spindle orientation (GO:0051294)2.33547059
175histone H3-K36 demethylation (GO:0070544)2.32526775
176regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.32512562
177amyloid precursor protein catabolic process (GO:0042987)2.32257022
178protein localization to chromosome, centromeric region (GO:0071459)2.32064061
179NADH metabolic process (GO:0006734)2.31880679
180phospholipid efflux (GO:0033700)2.31827237
181attachment of spindle microtubules to kinetochore (GO:0008608)2.31584267
182regulation of steroid hormone biosynthetic process (GO:0090030)2.31334507
183positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.30828607
184positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.30750452
185nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.28975242
186renal absorption (GO:0070293)2.28959621
187intracellular lipid transport (GO:0032365)2.27983658
188ER-nucleus signaling pathway (GO:0006984)2.27848860
189proline metabolic process (GO:0006560)2.27002488
190pentose-phosphate shunt (GO:0006098)2.26601218
191establishment of apical/basal cell polarity (GO:0035089)2.25851431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.91723386
2ZNF263_19887448_ChIP-Seq_K562_Human3.88676683
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.48075427
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.33949277
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.86305713
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.73839159
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.60564901
8AR_21909140_ChIP-Seq_LNCAP_Human2.57449602
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.57435917
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.56662648
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.55593808
12CLOCK_20551151_ChIP-Seq_293T_Human2.55026347
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.30661935
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.28014835
15TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.25755959
16GATA1_22025678_ChIP-Seq_K562_Human2.25712519
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.23337398
18SOX2_27498859_Chip-Seq_STOMACH_Mouse2.21034759
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.15394474
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.09928839
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01943277
22RACK7_27058665_Chip-Seq_MCF-7_Human1.99209595
23RXR_22158963_ChIP-Seq_LIVER_Mouse1.93205586
24GATA6_25053715_ChIP-Seq_YYC3_Human1.92510481
25RUNX1_27514584_Chip-Seq_MCF-7_Human1.92481549
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.91893166
27* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90634136
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.90451067
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.88415226
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.85303762
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.85303762
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.82629840
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80570869
34PPARA_22158963_ChIP-Seq_LIVER_Mouse1.79713849
35TP53_16413492_ChIP-PET_HCT116_Human1.78809957
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.78608526
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.77671903
38E2F7_22180533_ChIP-Seq_HELA_Human1.76369933
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.73525186
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.73415814
41STAT3_23295773_ChIP-Seq_U87_Human1.71132342
42SOX2_20726797_ChIP-Seq_SW620_Human1.69826990
43GATA3_24758297_ChIP-Seq_MCF-7_Human1.68299639
44ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.68015455
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67420364
46AR_21572438_ChIP-Seq_LNCaP_Human1.66125218
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.65567685
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.65517611
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.63949334
50GBX2_23144817_ChIP-Seq_PC3_Human1.62674907
51TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.62154714
52KAP1_22055183_ChIP-Seq_ESCs_Mouse1.61324794
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.61072523
54GATA1_26923725_Chip-Seq_HPCs_Mouse1.57257948
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56996583
56* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56115479
57LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55656943
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55169187
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53239993
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49739383
61MYC_22102868_ChIP-Seq_BL_Human1.46708867
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45764207
63FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44603511
64IGF1R_20145208_ChIP-Seq_DFB_Human1.44265234
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43738602
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.42274466
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39413758
68ATF3_27146783_Chip-Seq_COLON_Human1.39180953
69* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.38543756
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38045614
71* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37605061
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36898389
73TCF7_22412390_ChIP-Seq_EML_Mouse1.36847910
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.36626195
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35517753
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35482790
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33849283
78* CJUN_26792858_Chip-Seq_BT549_Human1.32987033
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30857804
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30719662
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30455305
82CDX2_22108803_ChIP-Seq_LS180_Human1.30159996
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29562209
84CHD1_26751641_Chip-Seq_LNCaP_Human1.28704279
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28019460
86EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26705786
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25397142
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25391895
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.24669125
90GATA4_25053715_ChIP-Seq_YYC3_Human1.24632079
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23530211
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22205119
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21371935
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21246102
95ER_23166858_ChIP-Seq_MCF-7_Human1.21121593
96AHR_22903824_ChIP-Seq_MCF-7_Human1.21116494
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20800128
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20653430
99TBL1_22424771_ChIP-Seq_293T_Human1.20587004
100P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20244281
101FOXA2_19822575_ChIP-Seq_HepG2_Human1.19993215
102FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.19379384
103TCF4_23295773_ChIP-Seq_U87_Human1.19331360
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.19186296
105EP300_21415370_ChIP-Seq_HL-1_Mouse1.18182461
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16243136
107STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15786778
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.15111414
109SMAD4_21799915_ChIP-Seq_A2780_Human1.14636434
110* TP63_23658742_ChIP-Seq_EP156T_Human1.14178720
111TCF4_18268006_ChIP-ChIP_LS174T_Human1.13884717
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12827243
113FUS_26573619_Chip-Seq_HEK293_Human1.12321157
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12267068
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10911354
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10663128
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.10297936
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09811002
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09624391
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08434088
121MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06589587
122TBX20_22080862_ChIP-Seq_HEART_Mouse1.06149658
123TBX20_22328084_ChIP-Seq_HEART_Mouse1.06149658
124* RXR_22108803_ChIP-Seq_LS180_Human1.05641474
125P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04328362
126ESR1_21235772_ChIP-Seq_MCF-7_Human1.03235603
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03207821
128CMYC_18555785_Chip-Seq_ESCs_Mouse1.02555327
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02536103
130EWS_26573619_Chip-Seq_HEK293_Human1.02272138
131NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01995613
132TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01814928
133CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01789753
134GATA2_21666600_ChIP-Seq_HMVEC_Human1.01368142
135* UBF1/2_26484160_Chip-Seq_HMECs_Human1.01171402
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01135478
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00382140
138PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00334564
139FOXA1_25552417_ChIP-Seq_VCAP_Human1.00108425
140KLF5_25053715_ChIP-Seq_YYC3_Human0.99989190
141NFYA_21822215_ChIP-Seq_K562_Human0.99341911
142DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99073136
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98839511
144BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98184066
145ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98155719
146POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97602388
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97602388
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97338849
149CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97014385
150SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96910085
151CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96600075
152Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96473734
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.96253281
154E2F1_18555785_Chip-Seq_ESCs_Mouse0.95787023
155SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95767189
156AR_25329375_ChIP-Seq_VCAP_Human0.95708646
157ELF5_23300383_ChIP-Seq_T47D_Human0.95217783
158BRD4_25478319_ChIP-Seq_HGPS_Human0.95119277
159* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94781009
160NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94530039
161CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94528935
162ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94525856
163ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94411559
164FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93409794
165PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93402019
166* HNF4A_19822575_ChIP-Seq_HepG2_Human0.93160905
167RUNX1_26923725_Chip-Seq_HPCs_Mouse0.92790814
168SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92312566
169* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91206129
170AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89853780
171ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87678036
172ELK3_25401928_ChIP-Seq_HUVEC_Human0.87525494
173RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87489851

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.35330436
2MP0004185_abnormal_adipocyte_glucose4.15491411
3MP0003941_abnormal_skin_development3.55715428
4MP0003718_maternal_effect3.46695325
5MP0000566_synostosis3.13431333
6MP0003950_abnormal_plasma_membrane3.11605695
7MP0003191_abnormal_cellular_cholesterol2.88705599
8MP0010678_abnormal_skin_adnexa2.86389009
9MP0002102_abnormal_ear_morphology2.66859919
10MP0005408_hypopigmentation2.58393506
11MP0004264_abnormal_extraembryonic_tissu2.51155240
12MP0005409_darkened_coat_color2.47171121
13MP0003937_abnormal_limbs/digits/tail_de2.46015957
14MP0005666_abnormal_adipose_tissue2.43938273
15MP0002009_preneoplasia2.40667066
16MP0001346_abnormal_lacrimal_gland2.37552905
17MP0000579_abnormal_nail_morphology2.37454626
18MP0000383_abnormal_hair_follicle2.32394673
19MP0000462_abnormal_digestive_system2.24061477
20MP0010234_abnormal_vibrissa_follicle2.22371575
21MP0004782_abnormal_surfactant_physiolog2.14163915
22MP0010352_gastrointestinal_tract_polyps2.08734254
23MP0005501_abnormal_skin_physiology2.04065397
24MP0005395_other_phenotype1.98584857
25MP0003699_abnormal_female_reproductive1.97360925
26MP0003183_abnormal_peptide_metabolism1.93209427
27MP0003787_abnormal_imprinting1.91374174
28MP0010307_abnormal_tumor_latency1.89664992
29MP0009780_abnormal_chondrocyte_physiolo1.86329243
30MP0005058_abnormal_lysosome_morphology1.81370481
31MP0002098_abnormal_vibrissa_morphology1.80880573
32MP0008877_abnormal_DNA_methylation1.79988829
33MP0003111_abnormal_nucleus_morphology1.79889630
34MP0005670_abnormal_white_adipose1.77236333
35MP0001849_ear_inflammation1.76526359
36MP0000427_abnormal_hair_cycle1.74335339
37MP0005375_adipose_tissue_phenotype1.66068583
38MP0003077_abnormal_cell_cycle1.62864252
39MP0004233_abnormal_muscle_weight1.61717421
40MP0008438_abnormal_cutaneous_collagen1.60574036
41MP0003705_abnormal_hypodermis_morpholog1.57181158
42MP0001299_abnormal_eye_distance/1.54682642
43MP0003646_muscle_fatigue1.54604906
44MP0001666_abnormal_nutrient_absorption1.52698131
45MP0003693_abnormal_embryo_hatching1.52625852
46MP0010094_abnormal_chromosome_stability1.52560728
47MP0001119_abnormal_female_reproductive1.50982245
48MP0009840_abnormal_foam_cell1.50887041
49MP0002166_altered_tumor_susceptibility1.50620161
50MP0000003_abnormal_adipose_tissue1.49400389
51MP0003690_abnormal_glial_cell1.47362508
52MP0009384_cardiac_valve_regurgitation1.43785755
53MP0000569_abnormal_digit_pigmentation1.42663762
54MP0004272_abnormal_basement_membrane1.37698438
55MP0003172_abnormal_lysosome_physiology1.37245136
56MP0004885_abnormal_endolymph1.37175955
57MP0000678_abnormal_parathyroid_gland1.36877902
58MP0004808_abnormal_hematopoietic_stem1.36728903
59MP0000920_abnormal_myelination1.32918555
60MP0003453_abnormal_keratinocyte_physiol1.32304524
61MP0002139_abnormal_hepatobiliary_system1.29391197
62MP0005310_abnormal_salivary_gland1.27988218
63MP0002653_abnormal_ependyma_morphology1.27456216
64MP0003091_abnormal_cell_migration1.26914556
65MP0000013_abnormal_adipose_tissue1.25660893
66MP0002909_abnormal_adrenal_gland1.24307006
67MP0002396_abnormal_hematopoietic_system1.23453895
68MP0005365_abnormal_bile_salt1.21197840
69MP0000653_abnormal_sex_gland1.20636115
70MP0000733_abnormal_muscle_development1.20467534
71MP0002084_abnormal_developmental_patter1.20197893
72MP0001929_abnormal_gametogenesis1.19980922
73MP0000467_abnormal_esophagus_morphology1.19697335
74MP0001661_extended_life_span1.19573296
75MP0002085_abnormal_embryonic_tissue1.18928524
76MP0001851_eye_inflammation1.18378855
77MP0002249_abnormal_larynx_morphology1.18045506
78MP0001873_stomach_inflammation1.17094204
79MP0000627_abnormal_mammary_gland1.16754356
80MP0000762_abnormal_tongue_morphology1.15317636
81MP0003632_abnormal_nervous_system1.14628782
82MP0005083_abnormal_biliary_tract1.13643204
83MP0002877_abnormal_melanocyte_morpholog1.10289635
84MP0005076_abnormal_cell_differentiation1.09999179
85MP0001915_intracranial_hemorrhage1.09673489
86MP0002210_abnormal_sex_determination1.09008994
87MP0003943_abnormal_hepatobiliary_system1.08930200
88MP0001765_abnormal_ion_homeostasis1.07806584
89MP0001730_embryonic_growth_arrest1.07794865
90MP0001881_abnormal_mammary_gland1.07604177
91MP0003123_paternal_imprinting1.06505856
92MP0005647_abnormal_sex_gland1.05689807
93MP0002168_other_aberrant_phenotype1.02425134
94MP0008260_abnormal_autophagy1.02410496
95MP0002060_abnormal_skin_morphology1.02284817
96MP0010630_abnormal_cardiac_muscle0.99813341
97MP0002006_tumorigenesis0.99782304
98MP0000350_abnormal_cell_proliferation0.99563857
99MP0003868_abnormal_feces_composition0.98571786
100MP0002971_abnormal_brown_adipose0.96391430
101MP0003755_abnormal_palate_morphology0.95486566
102MP0001672_abnormal_embryogenesis/_devel0.94652720
103MP0005380_embryogenesis_phenotype0.94652720
104MP0000534_abnormal_ureter_morphology0.94464219
105MP0006054_spinal_hemorrhage0.93643899
106MP0000537_abnormal_urethra_morphology0.91027418
107MP0003252_abnormal_bile_duct0.90840423
108MP0005275_abnormal_skin_tensile0.90742007
109MP0009931_abnormal_skin_appearance0.90374983
110MP0000432_abnormal_head_morphology0.90177407
111MP0008057_abnormal_DNA_replication0.90118709
112MP0002796_impaired_skin_barrier0.88600019
113MP0002161_abnormal_fertility/fecundity0.88598808
114MP0004957_abnormal_blastocyst_morpholog0.88584686
115MP0000647_abnormal_sebaceous_gland0.87708216
116MP0010771_integument_phenotype0.86948984
117MP0000639_abnormal_adrenal_gland0.86872384
118MP0002088_abnormal_embryonic_growth/wei0.86848693
119MP0002089_abnormal_postnatal_growth/wei0.85346549
120MP0009250_abnormal_appendicular_skeleto0.85059194
121MP0005023_abnormal_wound_healing0.84790220
122MP0003121_genomic_imprinting0.84433277
123MP0008875_abnormal_xenobiotic_pharmacok0.84137804
124MP0003938_abnormal_ear_development0.82310180
125MP0000377_abnormal_hair_follicle0.81332017
126MP0009643_abnormal_urine_homeostasis0.81232377
127MP0003936_abnormal_reproductive_system0.80392897
128MP0005623_abnormal_meninges_morphology0.80003333
129MP0000609_abnormal_liver_physiology0.79585309
130MP0006138_congestive_heart_failure0.79091062
131MP0005257_abnormal_intraocular_pressure0.78988697
132MP0001145_abnormal_male_reproductive0.78804586
133MP0004381_abnormal_hair_follicle0.78608477
134MP0003045_fibrosis0.77831759
135MP0003656_abnormal_erythrocyte_physiolo0.76970526
136MP0003329_amyloid_beta_deposits0.76861842
137MP0010329_abnormal_lipoprotein_level0.76460968
138MP0002896_abnormal_bone_mineralization0.76023883
139MP0005621_abnormal_cell_physiology0.75592496
140MP0001697_abnormal_embryo_size0.73870224
141MP0003984_embryonic_growth_retardation0.72393227
142MP0002086_abnormal_extraembryonic_tissu0.71354329
143MP0009672_abnormal_birth_weight0.69964231
144MP0004742_abnormal_vestibular_system0.69832689
145MP0009115_abnormal_fat_cell0.69745760
146MP0001216_abnormal_epidermal_layer0.69566985
147MP0003300_gastrointestinal_ulcer0.69521685
148MP0003935_abnormal_craniofacial_develop0.69431075
149MP0003566_abnormal_cell_adhesion0.68677341
150MP0008932_abnormal_embryonic_tissue0.68497515
151MP0002233_abnormal_nose_morphology0.68090684
152MP0005636_abnormal_mineral_homeostasis0.67541997
153MP0004084_abnormal_cardiac_muscle0.66884358
154MP0002080_prenatal_lethality0.63798795
155MP0003315_abnormal_perineum_morphology0.63160534
156MP0000598_abnormal_liver_morphology0.61864312
157MP0010368_abnormal_lymphatic_system0.61768243

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.77697194
2Flat acetabular roof (HP:0003180)4.11388614
3Male infertility (HP:0003251)4.00087955
4Papillary thyroid carcinoma (HP:0002895)3.80868002
5Oligodactyly (hands) (HP:0001180)3.66787517
6Chromsome breakage (HP:0040012)3.65495053
7Deep venous thrombosis (HP:0002625)3.53248138
8Insidious onset (HP:0003587)3.48008761
9Termporal pattern (HP:0011008)3.48008761
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40047483
11J-shaped sella turcica (HP:0002680)3.39511158
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.26218128
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.26218128
14Abnormality of the labia minora (HP:0012880)3.18838945
15Chin dimple (HP:0010751)3.14829507
16Abnormality of nail color (HP:0100643)3.11276704
17Ankyloglossia (HP:0010296)3.08483351
18Asymmetry of the thorax (HP:0001555)2.99119901
19Prostate neoplasm (HP:0100787)2.90759081
20Pili torti (HP:0003777)2.90443986
21Adrenal hypoplasia (HP:0000835)2.89680101
22Facial hemangioma (HP:0000329)2.78386234
23Acute myeloid leukemia (HP:0004808)2.77179940
24Abnormal tarsal ossification (HP:0008369)2.75977854
25Lip pit (HP:0100267)2.73344404
26Onion bulb formation (HP:0003383)2.72995687
27Abnormality of the common coagulation pathway (HP:0010990)2.61819482
28Abnormality of the corticospinal tract (HP:0002492)2.60898051
29Abnormality of the fingertips (HP:0001211)2.60275686
30Focal segmental glomerulosclerosis (HP:0000097)2.59530933
31Hyperactive renin-angiotensin system (HP:0000841)2.56438954
32Birth length less than 3rd percentile (HP:0003561)2.53286259
33Abnormality of oral frenula (HP:0000190)2.53224174
34Ectopic kidney (HP:0000086)2.50635876
35Onycholysis (HP:0001806)2.47268143
36Oligodactyly (HP:0012165)2.46548120
37Mucopolysacchariduria (HP:0008155)2.44851416
38Urinary glycosaminoglycan excretion (HP:0003541)2.44851416
39Shawl scrotum (HP:0000049)2.44174981
40Abnormality of the lacrimal duct (HP:0011481)2.43321314
41Abnormality of carpal bone ossification (HP:0006257)2.40539448
42Segmental peripheral demyelination/remyelination (HP:0003481)2.39121664
43Aplasia involving bones of the extremities (HP:0009825)2.38899220
44Aplasia involving bones of the upper limbs (HP:0009823)2.38899220
45Aplasia of the phalanges of the hand (HP:0009802)2.38899220
46Abnormality of the salivary glands (HP:0010286)2.36968697
47Shallow orbits (HP:0000586)2.34689906
48Nasolacrimal duct obstruction (HP:0000579)2.33894904
49Renal salt wasting (HP:0000127)2.32707398
50Micronodular cirrhosis (HP:0001413)2.29801297
51Advanced eruption of teeth (HP:0006288)2.27915496
52Aqueductal stenosis (HP:0002410)2.27412754
53Plantar hyperkeratosis (HP:0007556)2.26878113
54Germ cell neoplasia (HP:0100728)2.26501390
55Insulin-resistant diabetes mellitus (HP:0000831)2.26261022
56Abnormal foot bone ossification (HP:0010675)2.25768783
57Sparse lateral eyebrow (HP:0005338)2.25749259
58Flat capital femoral epiphysis (HP:0003370)2.23606696
59Abnormality of chromosome stability (HP:0003220)2.22646593
60Broad face (HP:0000283)2.22210654
61Septate vagina (HP:0001153)2.20559721
62Sensory axonal neuropathy (HP:0003390)2.19727246
63Heterotopia (HP:0002282)2.19684670
64Hypoplastic labia majora (HP:0000059)2.19584458
65Cortical dysplasia (HP:0002539)2.18131752
66Abnormality of the nasal septum (HP:0000419)2.17681632
67Breast aplasia (HP:0100783)2.15874692
68Abnormal hair laboratory examination (HP:0003328)2.14797078
69Subcapsular cataract (HP:0000523)2.13169367
70Capillary hemangiomas (HP:0005306)2.12959624
71Esophageal atresia (HP:0002032)2.12629493
72Ectropion (HP:0000656)2.12571512
73Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.12195711
74Cervical subluxation (HP:0003308)2.11826524
75Ridged nail (HP:0001807)2.11236818
76Hypoplasia of dental enamel (HP:0006297)2.10230314
77Abnormality of the labia majora (HP:0012881)2.09779975
78Anterior segment dysgenesis (HP:0007700)2.09769704
79Hand muscle atrophy (HP:0009130)2.07777332
80Esophageal varix (HP:0002040)2.07648483
81Abnormal auditory evoked potentials (HP:0006958)2.07642466
82Arterial tortuosity (HP:0005116)2.05617819
83Aplasia/Hypoplasia of the breasts (HP:0010311)2.05026431
84Curly hair (HP:0002212)2.04338019
85Sandal gap (HP:0001852)2.04160608
86Abnormality of monocarboxylic acid metabolism (HP:0010996)2.03937438
87Hypercholesterolemia (HP:0003124)2.03860497
88Abnormality of chloride homeostasis (HP:0011422)2.02764321
89Wide nose (HP:0000445)2.02683081
90Milia (HP:0001056)2.02251048
91Thyroid carcinoma (HP:0002890)2.02241094
92Coarse hair (HP:0002208)2.02129922
93Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00496666
94Abnormality of polysaccharide metabolism (HP:0011012)2.00496666
95Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00496666
96Dysmetric saccades (HP:0000641)1.99980886
97Distal upper limb amyotrophy (HP:0007149)1.98167809
98Upper limb amyotrophy (HP:0009129)1.98167809
99Deformed sella turcica (HP:0002681)1.97963714
100Primary amenorrhea (HP:0000786)1.96779638
101Abnormality of the nasolacrimal system (HP:0000614)1.96697501
102Abnormality of the gastric mucosa (HP:0004295)1.95564929
103Glomerulosclerosis (HP:0000096)1.93827115
104Abnormality of cochlea (HP:0000375)1.93202984
105Back pain (HP:0003418)1.92519242
106Abnormal ossification of hand bones (HP:0005921)1.92507638
107Facial shape deformation (HP:0011334)1.91373797
108Potter facies (HP:0002009)1.91373797
109Abnormality of the Achilles tendon (HP:0005109)1.91087629
110Testicular neoplasm (HP:0010788)1.90669978
111Subacute progressive viral hepatitis (HP:0006572)1.90218171
112Palmoplantar hyperkeratosis (HP:0000972)1.89879188
113Scanning speech (HP:0002168)1.89801042
114Abnormality of the labia (HP:0000058)1.89694268
115Neoplasm of the oral cavity (HP:0100649)1.88792790
116Vascular calcification (HP:0004934)1.88409829
117Abnormality of the distal phalanx of the thumb (HP:0009617)1.88100452
118Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.87266764
119Hammertoe (HP:0001765)1.86413912
120Myocardial infarction (HP:0001658)1.85994234
121Small epiphyses (HP:0010585)1.85745029
122Overlapping toe (HP:0001845)1.85507798
123Hyperaldosteronism (HP:0000859)1.85423382
124Hypotrichosis (HP:0001006)1.85044129
125Peripheral hypomyelination (HP:0007182)1.83282248
126Neurofibrillary tangles (HP:0002185)1.83160764
127Hyperkalemia (HP:0002153)1.83069644
128Abnormality of chromosome segregation (HP:0002916)1.83029756
129Breast hypoplasia (HP:0003187)1.82818258
130Absent radius (HP:0003974)1.82401529
131Volvulus (HP:0002580)1.81564174
132Acanthosis nigricans (HP:0000956)1.80788790
133Abnormality of the dental root (HP:0006486)1.80592436
134Taurodontia (HP:0000679)1.80592436
135Abnormality of permanent molar morphology (HP:0011071)1.80592436
136Hypobetalipoproteinemia (HP:0003563)1.78319587
137Absent eyelashes (HP:0000561)1.78275694
138Achilles tendon contracture (HP:0001771)1.78218021
139Duplicated collecting system (HP:0000081)1.76227766
140Coronal craniosynostosis (HP:0004440)1.75827030
141Fragile nails (HP:0001808)1.75564984
142Palmar hyperkeratosis (HP:0010765)1.74692430
143Abnormal hand bone ossification (HP:0010660)1.73389092
144Microtia (HP:0008551)1.72892658
145Macroorchidism (HP:0000053)1.72619442
146Increased circulating renin level (HP:0000848)1.72020706
147Ankle contracture (HP:0006466)1.71860685
148Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.71856419
149Cerebral inclusion bodies (HP:0100314)1.70309519
150Absent forearm bone (HP:0003953)1.70235883
151Aplasia involving forearm bones (HP:0009822)1.70235883
152Decreased motor nerve conduction velocity (HP:0003431)1.69782476
153Deviation of the thumb (HP:0009603)1.69662444
154Vascular tortuosity (HP:0004948)1.69145270
155Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68933214
156Relative macrocephaly (HP:0004482)1.68310790
157Seborrheic dermatitis (HP:0001051)1.68188858
158Neonatal death (HP:0003811)1.67961627
159Acanthocytosis (HP:0001927)1.66239669
160Hyponatremia (HP:0002902)1.65138676
161Abnormality of the lumbar spine (HP:0100712)1.63659204
162Chorioretinal atrophy (HP:0000533)1.63247495
163Dysostosis multiplex (HP:0000943)1.63142830
164Hemorrhage of the eye (HP:0011885)1.63099113
165Limited elbow extension (HP:0001377)1.62746857
166Hyperglycemia (HP:0003074)1.62163802
167Metabolic alkalosis (HP:0200114)1.61185263
168Neoplasm of the adrenal cortex (HP:0100641)1.60952593
169Abnormality of the renal collecting system (HP:0004742)1.60833263
170Aplasia/Hypoplasia of the uvula (HP:0010293)1.60362750
171Aortic dissection (HP:0002647)1.60158367
172Pterygium (HP:0001059)1.58977820
173Osteolytic defects of the phalanges of the hand (HP:0009771)1.58975325
174Osteolytic defects of the hand bones (HP:0009699)1.58975325
175Narrow palate (HP:0000189)1.57797255
176Ulnar claw (HP:0001178)1.57547767
177Patellar aplasia (HP:0006443)1.57405492
178Enlarged penis (HP:0000040)1.56835860
179Abnormality of the proximal phalanges of the hand (HP:0009834)1.56317039
180Spastic tetraparesis (HP:0001285)1.56003594
181Hypoplastic female external genitalia (HP:0012815)1.55947944
182Cupped ear (HP:0000378)1.55419296
183Synostosis of carpal bones (HP:0005048)1.54946257
184Urethral obstruction (HP:0000796)1.54079344
185Clitoromegaly (HP:0000057)1.53293437
186Ulnar bowing (HP:0003031)1.53276584
187Abnormality of the carotid arteries (HP:0005344)1.51919857
188Hypergonadotropic hypogonadism (HP:0000815)1.51722178
189Clubbing of toes (HP:0100760)1.51371660

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.08137400
2LATS23.85504361
3MST1R3.71924387
4SCYL23.58098110
5STK38L3.41980110
6ERBB43.22862275
7TRIB33.16801433
8SMG12.99394590
9RPS6KB22.93999526
10MAP3K62.72177485
11STK32.55729174
12KSR22.30054571
13TTK2.22744908
14STK392.21414300
15PKN22.16857498
16TAOK32.15121862
17FGFR42.08088335
18TAOK12.07154029
19RIPK12.05669379
20PLK41.98701394
21MAP3K21.96966893
22ICK1.88558960
23CAMK1D1.88457972
24EEF2K1.79331405
25OXSR11.79084395
26PAK61.78138526
27CDK121.78004553
28FGFR31.75009268
29PBK1.74157214
30RIPK41.70216041
31CDC71.66022983
32MAP3K91.61480117
33FGFR21.53298743
34ERN11.47665923
35RAF11.43765844
36EIF2AK11.41245585
37CAMK1G1.40618500
38NEK21.40325540
39CDK91.39646717
40PRPF4B1.39037008
41MAP3K131.37455675
42MELK1.35229151
43FRK1.34400883
44MAPKAPK51.33456867
45STK381.31247007
46NUAK11.28526757
47IRAK31.27750511
48CHEK21.25760866
49MOS1.25087304
50STK101.23728504
51EPHB11.23151114
52TRPM71.19970153
53MST41.19687249
54MET1.13028618
55EIF2AK31.08990401
56MUSK1.07649223
57DMPK1.06696671
58CSNK1G11.06222971
59BRAF1.05491738
60RPS6KB11.05377401
61FER1.03393722
62AKT30.99266451
63STK240.99229141
64PDGFRB0.97283529
65EPHA20.94992330
66SGK4940.94937562
67SGK2230.94937562
68TYRO30.94041023
69CDK80.92888776
70PRKAA20.90768280
71KSR10.89372491
72BRD40.86062342
73RET0.85660383
74PTK60.85253200
75TAF10.85145054
76ABL20.84239858
77MAP3K30.81543309
78TTN0.79041471
79PAK40.78781982
80FGFR10.78284256
81YES10.77868807
82FLT30.77374806
83DDR20.77058221
84PRKD20.77019677
85PRKD30.76817689
86PDGFRA0.75884681
87MAP2K10.75745658
88CSNK1A1L0.75527162
89MATK0.74680764
90MAPKAPK30.73809278
91MARK20.72381654
92WNK10.71004104
93MAP3K80.68137443
94MAP3K140.67614670
95PRKAA10.66315492
96NME20.66047727
97MAP3K10.65877343
98EIF2AK20.64934832
99PDK10.63112571
100SGK20.61598149
101LRRK20.60426857
102PAK30.60147384
103MAP2K20.59946770
104MAP3K40.59002814
105ABL10.58361716
106AURKB0.58256445
107DYRK20.56924582
108PLK10.56411649
109BCR0.56324960
110MAP3K120.56219626
111ALK0.54861981
112ARAF0.54662976
113CSNK1G20.54575996
114PDK20.52133694
115CSNK1D0.52026901
116SGK30.49975311
117NTRK10.49484098
118CHEK10.49108756
119NEK60.48364720
120ATM0.47340415
121MTOR0.46899708
122LMTK20.44990832
123CSF1R0.44690281
124MAPK100.44686685
125PIK3CA0.44066772
126CSNK1G30.43650592
127MAP2K40.43218906
128CDK40.41258795
129BMPR20.41033263
130STK110.39538568
131PDPK10.38606575
132MAP2K30.37576920
133CDK70.37436547
134ITK0.36898258
135SIK10.36058624
136AKT20.35875501
137CDK60.34671910
138PRKG20.33959762
139BMX0.33759172
140PTK20.33279494
141NEK90.33041360
142PAK10.32387047
143JAK20.31842187
144JAK30.31608859
145CDK10.30578530
146FGR0.30330253
147JAK10.29695283
148WNK40.29428721
149PAK20.28773660
150MAPK110.28124068
151MAPKAPK20.27602416
152ROCK20.26895835

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.64425857
2Other glycan degradation_Homo sapiens_hsa005112.39106444
3Ovarian steroidogenesis_Homo sapiens_hsa049132.26970981
4Dorso-ventral axis formation_Homo sapiens_hsa043202.15847533
5Ether lipid metabolism_Homo sapiens_hsa005652.05888546
6Cell cycle_Homo sapiens_hsa041102.05569474
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.00614383
8Nitrogen metabolism_Homo sapiens_hsa009101.95888428
9Fatty acid biosynthesis_Homo sapiens_hsa000611.88279468
10Pancreatic cancer_Homo sapiens_hsa052121.87872081
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87462595
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81766054
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.75963232
14Pentose phosphate pathway_Homo sapiens_hsa000301.70597879
15Central carbon metabolism in cancer_Homo sapiens_hsa052301.66082602
16Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.60954038
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57932335
18N-Glycan biosynthesis_Homo sapiens_hsa005101.56058008
19MicroRNAs in cancer_Homo sapiens_hsa052061.55349319
20Renal cell carcinoma_Homo sapiens_hsa052111.50385772
21Steroid biosynthesis_Homo sapiens_hsa001001.48382454
22Linoleic acid metabolism_Homo sapiens_hsa005911.48309335
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42040973
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40053960
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39436499
26Circadian rhythm_Homo sapiens_hsa047101.36555732
27Phenylalanine metabolism_Homo sapiens_hsa003601.33871997
28TGF-beta signaling pathway_Homo sapiens_hsa043501.33550235
29Basal transcription factors_Homo sapiens_hsa030221.30213402
30Arginine biosynthesis_Homo sapiens_hsa002201.29633029
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28853873
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.26896630
33Sphingolipid metabolism_Homo sapiens_hsa006001.23641540
34Choline metabolism in cancer_Homo sapiens_hsa052311.23588140
35Insulin resistance_Homo sapiens_hsa049311.22334354
36Complement and coagulation cascades_Homo sapiens_hsa046101.19764674
37Hippo signaling pathway_Homo sapiens_hsa043901.19294119
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19075500
39Fructose and mannose metabolism_Homo sapiens_hsa000511.17853458
40Small cell lung cancer_Homo sapiens_hsa052221.16669220
41Oocyte meiosis_Homo sapiens_hsa041141.15671116
42Adherens junction_Homo sapiens_hsa045201.15156432
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15142074
44p53 signaling pathway_Homo sapiens_hsa041151.11143376
45Acute myeloid leukemia_Homo sapiens_hsa052211.09626914
46Insulin signaling pathway_Homo sapiens_hsa049101.09149943
47Carbon metabolism_Homo sapiens_hsa012001.07546238
48Lysine degradation_Homo sapiens_hsa003101.07482061
49ErbB signaling pathway_Homo sapiens_hsa040121.07153240
50Bile secretion_Homo sapiens_hsa049761.06904240
51Thyroid hormone synthesis_Homo sapiens_hsa049181.06371144
52Hepatitis C_Homo sapiens_hsa051601.05299002
53RNA degradation_Homo sapiens_hsa030181.05054489
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.03250338
55Fatty acid degradation_Homo sapiens_hsa000711.03206496
56Prostate cancer_Homo sapiens_hsa052151.02342696
57Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01829778
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.01257457
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00559184
60Endometrial cancer_Homo sapiens_hsa052130.99794797
61Inositol phosphate metabolism_Homo sapiens_hsa005620.99377109
62PPAR signaling pathway_Homo sapiens_hsa033200.98379800
63Fanconi anemia pathway_Homo sapiens_hsa034600.96933002
64Tight junction_Homo sapiens_hsa045300.95341413
65Non-small cell lung cancer_Homo sapiens_hsa052230.95258102
66Biosynthesis of amino acids_Homo sapiens_hsa012300.94665102
67ECM-receptor interaction_Homo sapiens_hsa045120.94152290
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93900757
69Prolactin signaling pathway_Homo sapiens_hsa049170.92783634
70Chronic myeloid leukemia_Homo sapiens_hsa052200.90401820
71Mineral absorption_Homo sapiens_hsa049780.90280536
72Fatty acid metabolism_Homo sapiens_hsa012120.90057074
73B cell receptor signaling pathway_Homo sapiens_hsa046620.89569570
74Glioma_Homo sapiens_hsa052140.89389496
75Galactose metabolism_Homo sapiens_hsa000520.88916931
76Pyruvate metabolism_Homo sapiens_hsa006200.88842329
77Bladder cancer_Homo sapiens_hsa052190.88437134
78Non-homologous end-joining_Homo sapiens_hsa034500.87094467
79Ras signaling pathway_Homo sapiens_hsa040140.87081912
80mTOR signaling pathway_Homo sapiens_hsa041500.87051019
81GnRH signaling pathway_Homo sapiens_hsa049120.86816103
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85642753
83Lysosome_Homo sapiens_hsa041420.85282908
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.84981188
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84524533
86AMPK signaling pathway_Homo sapiens_hsa041520.83874101
87Amoebiasis_Homo sapiens_hsa051460.83523583
88Melanoma_Homo sapiens_hsa052180.83452832
89Glycerolipid metabolism_Homo sapiens_hsa005610.82488870
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.82131759
91Starch and sucrose metabolism_Homo sapiens_hsa005000.81304210
92FoxO signaling pathway_Homo sapiens_hsa040680.81237622
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79583280
94Prion diseases_Homo sapiens_hsa050200.78750226
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78230500
96Renin-angiotensin system_Homo sapiens_hsa046140.78011483
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77823133
98Colorectal cancer_Homo sapiens_hsa052100.75757984
99Fatty acid elongation_Homo sapiens_hsa000620.75523500
100Glucagon signaling pathway_Homo sapiens_hsa049220.75066834
101Focal adhesion_Homo sapiens_hsa045100.74450108
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73929613
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73151653
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71634247
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70535006
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69936817
107HIF-1 signaling pathway_Homo sapiens_hsa040660.69710251
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69599733
109Vitamin digestion and absorption_Homo sapiens_hsa049770.69300998
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65742693
111Proteoglycans in cancer_Homo sapiens_hsa052050.64773152
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64380748
113Notch signaling pathway_Homo sapiens_hsa043300.63276068
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62630161
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61651699
116Basal cell carcinoma_Homo sapiens_hsa052170.61457190
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60720527
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60471270
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60031062
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57421247
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57306600
122Pathways in cancer_Homo sapiens_hsa052000.56359393
123Long-term depression_Homo sapiens_hsa047300.55850730
124VEGF signaling pathway_Homo sapiens_hsa043700.55451345
125Axon guidance_Homo sapiens_hsa043600.55218859
126Hedgehog signaling pathway_Homo sapiens_hsa043400.53908741
127Histidine metabolism_Homo sapiens_hsa003400.52549818
128Platelet activation_Homo sapiens_hsa046110.51430206
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51163478
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51131354
131Arginine and proline metabolism_Homo sapiens_hsa003300.50610866
132Wnt signaling pathway_Homo sapiens_hsa043100.50552515
133Long-term potentiation_Homo sapiens_hsa047200.50259980
134Propanoate metabolism_Homo sapiens_hsa006400.49092096
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48195251
136Pancreatic secretion_Homo sapiens_hsa049720.48137377
137MAPK signaling pathway_Homo sapiens_hsa040100.48034485
138cAMP signaling pathway_Homo sapiens_hsa040240.47606836
139Thyroid cancer_Homo sapiens_hsa052160.47438290
140Rap1 signaling pathway_Homo sapiens_hsa040150.47421478
141Endocytosis_Homo sapiens_hsa041440.44367451
142Estrogen signaling pathway_Homo sapiens_hsa049150.42908883
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41714442
144beta-Alanine metabolism_Homo sapiens_hsa004100.41297183
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.41057728
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.39105411
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38439158
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37462584
149Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36188470
150Viral carcinogenesis_Homo sapiens_hsa052030.34301531
151ABC transporters_Homo sapiens_hsa020100.34013257

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