ERN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.85815830
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.85815830
3positive regulation of gamma-delta T cell activation (GO:0046645)5.36040324
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.25082324
5L-phenylalanine catabolic process (GO:0006559)5.23859183
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.23859183
7L-phenylalanine metabolic process (GO:0006558)4.92007070
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.92007070
9regulation of B cell receptor signaling pathway (GO:0050855)4.68795242
10protein carboxylation (GO:0018214)4.68044070
11peptidyl-glutamic acid carboxylation (GO:0017187)4.68044070
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.67897626
13antigen processing and presentation of endogenous antigen (GO:0019883)4.67291842
14response to interleukin-15 (GO:0070672)4.61476096
15complement activation, alternative pathway (GO:0006957)4.60364694
16aromatic amino acid family catabolic process (GO:0009074)4.60287047
17cysteine metabolic process (GO:0006534)4.53554903
18sulfur amino acid catabolic process (GO:0000098)4.51775863
19urea cycle (GO:0000050)4.45804322
20urea metabolic process (GO:0019627)4.45804322
21regulation of gamma-delta T cell activation (GO:0046643)4.44448566
22COPI coating of Golgi vesicle (GO:0048205)4.43683403
23Golgi transport vesicle coating (GO:0048200)4.43683403
24negative T cell selection (GO:0043383)4.42937769
25regulation of gamma-delta T cell differentiation (GO:0045586)4.36116139
26negative thymic T cell selection (GO:0045060)4.35937737
27cellular response to interleukin-15 (GO:0071350)4.29409874
28tolerance induction (GO:0002507)4.26676951
29regulation of protein activation cascade (GO:2000257)4.25646891
30kynurenine metabolic process (GO:0070189)4.17739510
31regulation of cholesterol homeostasis (GO:2000188)4.16966613
32tryptophan catabolic process (GO:0006569)4.15406630
33indole-containing compound catabolic process (GO:0042436)4.15406630
34indolalkylamine catabolic process (GO:0046218)4.15406630
35alpha-linolenic acid metabolic process (GO:0036109)4.13980661
36tryptophan metabolic process (GO:0006568)4.09594526
37triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.08961616
38T cell migration (GO:0072678)4.05426297
39regulation of complement activation (GO:0030449)4.05097851
40high-density lipoprotein particle remodeling (GO:0034375)4.04132540
41nitrogen cycle metabolic process (GO:0071941)3.99770480
42bile acid biosynthetic process (GO:0006699)3.97441224
43negative regulation of fibrinolysis (GO:0051918)3.97346310
44leukocyte aggregation (GO:0070486)3.94662383
45homocysteine metabolic process (GO:0050667)3.81990755
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.75846114
47negative regulation of T cell mediated immunity (GO:0002710)3.71428541
48reverse cholesterol transport (GO:0043691)3.70938754
49regulation of fibrinolysis (GO:0051917)3.69629998
50COPII vesicle coating (GO:0048208)3.67892903
51bile acid metabolic process (GO:0008206)3.66528023
52dendritic cell chemotaxis (GO:0002407)3.61841385
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.61824226
54intestinal cholesterol absorption (GO:0030299)3.61316252
55bile acid and bile salt transport (GO:0015721)3.60708243
56negative regulation of lymphocyte mediated immunity (GO:0002707)3.60367334
57cellular extravasation (GO:0045123)3.59596063
58response to muramyl dipeptide (GO:0032495)3.56773437
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.54649714
60positive regulation by organism of defense response of other organism involved in symbiotic interact3.54649714
61modulation by symbiont of host immune response (GO:0052553)3.54649714
62positive regulation by symbiont of host defense response (GO:0052509)3.54649714
63modulation by symbiont of host defense response (GO:0052031)3.54649714
64modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.54649714
65valine metabolic process (GO:0006573)3.52995051
66positive thymic T cell selection (GO:0045059)3.51251596
67plasma lipoprotein particle assembly (GO:0034377)3.50369276
68positive T cell selection (GO:0043368)3.48714483
69serine family amino acid catabolic process (GO:0009071)3.48571616
70glyoxylate metabolic process (GO:0046487)3.46678012
71phospholipid homeostasis (GO:0055091)3.46644816
72acylglycerol homeostasis (GO:0055090)3.46357471
73triglyceride homeostasis (GO:0070328)3.46357471
74phospholipid efflux (GO:0033700)3.44444116
75T cell selection (GO:0045058)3.44141171
76thymic T cell selection (GO:0045061)3.43707398
77lysine metabolic process (GO:0006553)3.41488820
78lysine catabolic process (GO:0006554)3.41488820
79macroautophagy (GO:0016236)3.39899165
80plasma lipoprotein particle remodeling (GO:0034369)3.38844646
81protein-lipid complex remodeling (GO:0034368)3.38844646
82macromolecular complex remodeling (GO:0034367)3.38844646
83neutrophil activation involved in immune response (GO:0002283)3.37240503
84dendritic cell migration (GO:0036336)3.37147275
85negative regulation of interleukin-12 production (GO:0032695)3.36033302
86detection of other organism (GO:0098543)3.35728077
87negative regulation of cholesterol transport (GO:0032375)3.34232828
88negative regulation of sterol transport (GO:0032372)3.34232828
89protein-lipid complex assembly (GO:0065005)3.33781944
90regulation of T cell mediated cytotoxicity (GO:0001914)3.33774570
91neutrophil activation (GO:0042119)3.31873858
92aromatic amino acid family metabolic process (GO:0009072)3.31113670
93cellular modified amino acid catabolic process (GO:0042219)3.29429710
94regulation of triglyceride catabolic process (GO:0010896)3.28430625
95negative regulation of leukocyte mediated immunity (GO:0002704)3.27840563
96tyrosine metabolic process (GO:0006570)3.27773677
97activated T cell proliferation (GO:0050798)3.25731265
98regulation of alpha-beta T cell proliferation (GO:0046640)3.24309266
99cholesterol efflux (GO:0033344)3.22496388
100regulation of interferon-beta biosynthetic process (GO:0045357)3.22459603
101plasma lipoprotein particle clearance (GO:0034381)3.21919004
102very-low-density lipoprotein particle assembly (GO:0034379)3.21200807
103detection of bacterium (GO:0016045)3.19912389
104macrophage activation involved in immune response (GO:0002281)3.19864045
105positive regulation of T cell mediated cytotoxicity (GO:0001916)3.17137796
106positive regulation of granulocyte differentiation (GO:0030854)3.16471171
107detection of molecule of bacterial origin (GO:0032490)3.15827761
108complement activation, classical pathway (GO:0006958)3.15561027
109* activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.13069581
110regulation of regulatory T cell differentiation (GO:0045589)3.12307584
111amino-acid betaine metabolic process (GO:0006577)3.11017032
112indolalkylamine metabolic process (GO:0006586)3.10808565
113coenzyme catabolic process (GO:0009109)3.10176717
114antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08190034
115antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.08190034
116complement activation (GO:0006956)3.07680602
117response to type I interferon (GO:0034340)3.07393014
118type I interferon signaling pathway (GO:0060337)3.06008565
119cellular response to type I interferon (GO:0071357)3.06008565
120regulation of T cell tolerance induction (GO:0002664)3.05745933
121antigen processing and presentation via MHC class Ib (GO:0002475)3.05697807
122T-helper cell differentiation (GO:0042093)3.05514728
123CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.05514728
124plasma lipoprotein particle organization (GO:0071827)3.05319586
125detection of external biotic stimulus (GO:0098581)3.05230906
126regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.04887210
127granulocyte activation (GO:0036230)3.04233716
128acute-phase response (GO:0006953)3.03605103
129L-alpha-amino acid transmembrane transport (GO:1902475)3.02441458
130neutrophil mediated immunity (GO:0002446)3.01864893
131maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.01138130
132fibrinolysis (GO:0042730)2.99424415
133response to peptidoglycan (GO:0032494)2.99149320
134alpha-amino acid catabolic process (GO:1901606)2.99070130
135B cell receptor signaling pathway (GO:0050853)2.98909825
136germinal center formation (GO:0002467)2.98770700
137protein-lipid complex subunit organization (GO:0071825)2.98594664
138regulation of B cell differentiation (GO:0045577)2.98298918
139negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.97974269
140* positive regulation of nuclease activity (GO:0032075)2.97603763
1414-hydroxyproline metabolic process (GO:0019471)2.97589182
142regulation of natural killer cell mediated immunity (GO:0002715)2.95116951
143regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.95116951
144regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.93703417
145positive regulation of alpha-beta T cell proliferation (GO:0046641)2.92360620
146ethanol oxidation (GO:0006069)2.92196081
147protein activation cascade (GO:0072376)2.91651032
148interferon-gamma production (GO:0032609)2.91190758
149interferon-gamma secretion (GO:0072643)2.90842101
150benzene-containing compound metabolic process (GO:0042537)2.89375524
151one-carbon metabolic process (GO:0006730)2.89342899
152lipoprotein metabolic process (GO:0042157)2.88213211
153regulation of leukocyte mediated cytotoxicity (GO:0001910)2.87636311
154regulation of tolerance induction (GO:0002643)2.84781879
155positive regulation of fatty acid beta-oxidation (GO:0032000)2.84760318
1562-oxoglutarate metabolic process (GO:0006103)2.84674357
157intestinal absorption (GO:0050892)2.83675939
158cytolysis (GO:0019835)2.83444807
159glutamate metabolic process (GO:0006536)2.83244216
160negative regulation of lipase activity (GO:0060192)2.82846404
161positive regulation of tolerance induction (GO:0002645)2.82728142
162mannose metabolic process (GO:0006013)2.81718366
163cellular amino acid catabolic process (GO:0009063)2.80680408
164negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.79831967
165sterol homeostasis (GO:0055092)2.79812996
166cholesterol homeostasis (GO:0042632)2.79773077
167* endoplasmic reticulum unfolded protein response (GO:0030968)2.78626622
168leukocyte degranulation (GO:0043299)2.77587827
169regulation of fatty acid beta-oxidation (GO:0031998)2.77485487
170drug transmembrane transport (GO:0006855)2.77437615
171imidazole-containing compound metabolic process (GO:0052803)2.77289791
172glycine metabolic process (GO:0006544)2.76965739
173myeloid cell activation involved in immune response (GO:0002275)2.76719068
174hormone catabolic process (GO:0042447)2.75683758
175positive regulation of interleukin-2 production (GO:0032743)2.75436017
176negative regulation of lipid transport (GO:0032369)2.75318666
177regulation of necroptotic process (GO:0060544)2.73345782
178negative regulation of innate immune response (GO:0045824)2.72090059
179mast cell activation (GO:0045576)2.71723421
180negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.71292564
181positive regulation of T cell differentiation in thymus (GO:0033089)2.69924230
182detection of biotic stimulus (GO:0009595)2.68778162
183positive regulation of B cell differentiation (GO:0045579)2.68615072
184regulation of cell killing (GO:0031341)2.68274896
185regulation of T cell mediated immunity (GO:0002709)2.66371090
186hepatocyte apoptotic process (GO:0097284)2.66336283
187T cell differentiation involved in immune response (GO:0002292)2.66201434
188alpha-beta T cell differentiation involved in immune response (GO:0002293)2.66201434
189alpha-beta T cell activation involved in immune response (GO:0002287)2.66201434
190negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.65236639
191positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.64671720
192lipopolysaccharide-mediated signaling pathway (GO:0031663)2.64319063
193positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.63688367
194antigen receptor-mediated signaling pathway (GO:0050851)2.63621683
195lymphocyte migration (GO:0072676)2.62815159
196cellular response to ethanol (GO:0071361)2.62153946
197B cell homeostasis (GO:0001782)2.62042362
198T cell receptor signaling pathway (GO:0050852)2.60047802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.60303927
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.75898480
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.43725713
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.09498701
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.83313284
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.01574731
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.45931894
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.36631076
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.22924289
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.16976555
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.01350947
12GATA1_22025678_ChIP-Seq_K562_Human2.87480371
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.63432006
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.51629873
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48764891
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.45429936
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.25308177
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21576851
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.16431807
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.16236749
21CLOCK_20551151_ChIP-Seq_293T_Human2.13150939
22SPI1_23127762_ChIP-Seq_K562_Human1.97291995
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96740932
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.95923480
25SPI1_23547873_ChIP-Seq_NB4_Human1.84491138
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79703736
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76952018
28VDR_24787735_ChIP-Seq_THP-1_Human1.75936797
29* FOXA2_19822575_ChIP-Seq_HepG2_Human1.74859816
30GATA3_26560356_Chip-Seq_TH2_Human1.74417604
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74004399
32SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72343293
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71835395
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67333326
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.66804126
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66644395
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.64601279
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61925450
39MAF_26560356_Chip-Seq_TH2_Human1.61301485
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55476928
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52836819
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.50321127
43SCL_19346495_ChIP-Seq_HPC-7_Human1.50123318
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45985044
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44533829
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43686896
47MYC_22102868_ChIP-Seq_BL_Human1.42864569
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.41374328
49TCF7_22412390_ChIP-Seq_EML_Mouse1.40844535
50* FOXO3_23340844_ChIP-Seq_DLD1_Human1.38667301
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36993504
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36253659
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.35556925
54TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.35449446
55GATA6_25053715_ChIP-Seq_YYC3_Human1.31889736
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29268578
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28439265
58GATA4_25053715_ChIP-Seq_YYC3_Human1.27794815
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27212542
60KDM2B_26808549_Chip-Seq_DND41_Human1.25960638
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25636719
62* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23742022
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23237720
64* HNF4A_19822575_ChIP-Seq_HepG2_Human1.21666145
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19670670
66* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19304815
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17061868
68GATA1_19941826_ChIP-Seq_K562_Human1.15633266
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.14681534
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14375184
71* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14270387
72BP1_19119308_ChIP-ChIP_Hs578T_Human1.13907998
73* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12536458
74FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12291022
75* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11862474
76* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11749426
77STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09997820
78MYB_26560356_Chip-Seq_TH1_Human1.09562588
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08846131
80GATA2_19941826_ChIP-Seq_K562_Human1.08772749
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07995341
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06992339
83* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06314135
84VDR_21846776_ChIP-Seq_THP-1_Human1.05917598
85* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05168784
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.04403293
87* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04265070
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03235756
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02930015
90FOXA1_25552417_ChIP-Seq_VCAP_Human1.02740965
91FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00834068
92UTX_26944678_Chip-Seq_JUKART_Human1.00586153
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00094384
94ESR1_20079471_ChIP-ChIP_T-47D_Human0.99641654
95* KDM2B_26808549_Chip-Seq_JURKAT_Human0.99605837
96MYB_26560356_Chip-Seq_TH2_Human0.98868234
97NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98411244
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95782964
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94907233
100MAF_26560356_Chip-Seq_TH1_Human0.94524053
101RUNX_20019798_ChIP-Seq_JUKART_Human0.94089122
102VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94084089
103GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93728335
104GATA3_27048872_Chip-Seq_THYMUS_Human0.93155807
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93094047
106VDR_24763502_ChIP-Seq_THP-1_Human0.92075179
107* ATF3_27146783_Chip-Seq_COLON_Human0.90842031
108PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90066842
109* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90064440
110STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89522880
111PU_27001747_Chip-Seq_BMDM_Mouse0.89098722
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89059174
113* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87910678
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87439373
115SMRT_27268052_Chip-Seq_Bcells_Human0.86619475
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85415862
117* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85364150
118* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85132412
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84304497
120RACK7_27058665_Chip-Seq_MCF-7_Human0.84013870
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83725029
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83630094
123* RUNX1_22412390_ChIP-Seq_EML_Mouse0.82715735
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82474197
125* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82041779
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80965772
127GATA3_24758297_ChIP-Seq_MCF-7_Human0.80212415
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80078463
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79978980
130TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79195466
131TBX20_22328084_ChIP-Seq_HEART_Mouse0.79008934
132TBX20_22080862_ChIP-Seq_HEART_Mouse0.79008934
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78945090
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78669669
135* NCOR1_26117541_ChIP-Seq_K562_Human0.78030657
136FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77821684
137ELK3_25401928_ChIP-Seq_HUVEC_Human0.76974198
138ELF1_17652178_ChIP-ChIP_JURKAT_Human0.75047461
139PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72313527
140SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72146231
141GATA1_19941827_ChIP-Seq_MEL86_Mouse0.71708727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.75384879
2MP0005360_urolithiasis4.97923991
3MP0005365_abnormal_bile_salt4.90245797
4MP0005085_abnormal_gallbladder_physiolo4.26606374
5MP0003252_abnormal_bile_duct3.56645247
6MP0008875_abnormal_xenobiotic_pharmacok3.42788935
7MP0005671_abnormal_response_to3.41457434
8MP0003763_abnormal_thymus_physiology3.32791467
9MP0005000_abnormal_immune_tolerance2.93499056
10MP0009840_abnormal_foam_cell2.81358755
11MP0010329_abnormal_lipoprotein_level2.70358846
12MP0002723_abnormal_immune_serum2.65368531
13MP0009785_altered_susceptibility_to2.65201722
14MP0002452_abnormal_antigen_presenting2.51621389
15MP0002420_abnormal_adaptive_immunity2.47620305
16MP0001819_abnormal_immune_cell2.45742558
17MP0001666_abnormal_nutrient_absorption2.44565188
18MP0003300_gastrointestinal_ulcer2.42480384
19MP0003195_calcinosis2.41749515
20MP0002148_abnormal_hypersensitivity_rea2.36941225
21MP0005083_abnormal_biliary_tract2.32554884
22MP0002877_abnormal_melanocyte_morpholog2.19709195
23MP0002405_respiratory_system_inflammati2.12613754
24MP0000609_abnormal_liver_physiology2.08985253
25MP0006082_CNS_inflammation2.06127466
26MP0003806_abnormal_nucleotide_metabolis2.03997036
27MP0003868_abnormal_feces_composition2.03029364
28MP0009333_abnormal_splenocyte_physiolog2.01391147
29* MP0002398_abnormal_bone_marrow1.95642605
30MP0003191_abnormal_cellular_cholesterol1.92582936
31* MP0000716_abnormal_immune_system1.90985606
32MP0002138_abnormal_hepatobiliary_system1.88717178
33MP0003705_abnormal_hypodermis_morpholog1.84966405
34MP0002009_preneoplasia1.72980425
35MP0005220_abnormal_exocrine_pancreas1.68470807
36MP0000689_abnormal_spleen_morphology1.67693682
37MP0002722_abnormal_immune_system1.66613487
38MP0002118_abnormal_lipid_homeostasis1.65280987
39MP0005058_abnormal_lysosome_morphology1.65156394
40MP0005332_abnormal_amino_acid1.64372724
41MP0000703_abnormal_thymus_morphology1.64140031
42MP0004381_abnormal_hair_follicle1.62689737
43MP0003866_abnormal_defecation1.55736801
44MP0005319_abnormal_enzyme/_coenzyme1.52772070
45MP0003828_pulmonary_edema1.52319696
46* MP0002429_abnormal_blood_cell1.48484631
47MP0009643_abnormal_urine_homeostasis1.42894976
48MP0002998_abnormal_bone_remodeling1.42354901
49MP0010234_abnormal_vibrissa_follicle1.42352617
50MP0002933_joint_inflammation1.38415261
51MP0001851_eye_inflammation1.37936877
52MP0002693_abnormal_pancreas_physiology1.36410474
53MP0004019_abnormal_vitamin_homeostasis1.36287889
54MP0001944_abnormal_pancreas_morphology1.35880746
55MP0002928_abnormal_bile_duct1.29115897
56MP0002396_abnormal_hematopoietic_system1.22763533
57MP0002909_abnormal_adrenal_gland1.21743615
58MP0003656_abnormal_erythrocyte_physiolo1.21379333
59MP0004883_abnormal_blood_vessel1.21048690
60MP0005075_abnormal_melanosome_morpholog1.18680441
61* MP0000598_abnormal_liver_morphology1.18625533
62MP0000858_altered_metastatic_potential1.17626861
63MP0003436_decreased_susceptibility_to1.17418976
64MP0005464_abnormal_platelet_physiology1.15667603
65* MP0004264_abnormal_extraembryonic_tissu1.15018655
66MP0005408_hypopigmentation1.14751953
67MP0002166_altered_tumor_susceptibility1.14476326
68MP0005164_abnormal_response_to1.14208267
69MP0004947_skin_inflammation1.13894976
70MP0008004_abnormal_stomach_pH1.12708707
71MP0005451_abnormal_body_composition1.11929886
72* MP0002078_abnormal_glucose_homeostasis1.11729073
73MP0003183_abnormal_peptide_metabolism1.08141256
74MP0003303_peritoneal_inflammation1.07585396
75MP0008469_abnormal_protein_level1.05687215
76MP0010368_abnormal_lymphatic_system1.05029379
77MP0005076_abnormal_cell_differentiation1.01770432
78MP0001765_abnormal_ion_homeostasis1.00363145
79MP0009763_increased_sensitivity_to0.99699620
80MP0005636_abnormal_mineral_homeostasis0.98802809
81MP0003172_abnormal_lysosome_physiology0.98760222
82MP0008961_abnormal_basal_metabolism0.97692185
83MP0001853_heart_inflammation0.97144237
84MP0005647_abnormal_sex_gland0.94679269
85MP0009278_abnormal_bone_marrow0.94079230
86MP0000569_abnormal_digit_pigmentation0.93344454
87MP0003724_increased_susceptibility_to0.93050696
88MP0003566_abnormal_cell_adhesion0.93008258
89MP0009764_decreased_sensitivity_to0.92756810
90MP0001764_abnormal_homeostasis0.92383066
91MP0001756_abnormal_urination0.91531286
92MP0001845_abnormal_inflammatory_respons0.90516171
93MP0001881_abnormal_mammary_gland0.90107382
94MP0000685_abnormal_immune_system0.89336935
95MP0003690_abnormal_glial_cell0.88435518
96MP0005584_abnormal_enzyme/coenzyme_acti0.88210777
97MP0008260_abnormal_autophagy0.86458949
98MP0009642_abnormal_blood_homeostasis0.86308116
99MP0000249_abnormal_blood_vessel0.86075501
100MP0005310_abnormal_salivary_gland0.84884687
101MP0010155_abnormal_intestine_physiology0.84870779
102MP0010352_gastrointestinal_tract_polyps0.83733121
103MP0005166_decreased_susceptibility_to0.83477861
104MP0000604_amyloidosis0.82902184
105MP0004510_myositis0.82523541
106MP0002254_reproductive_system_inflammat0.82222790
107MP0002132_abnormal_respiratory_system0.81666692
108MP0003448_altered_tumor_morphology0.81300512
109MP0001873_stomach_inflammation0.79608666
110MP0005334_abnormal_fat_pad0.79562658
111MP0004185_abnormal_adipocyte_glucose0.79043631
112MP0002419_abnormal_innate_immunity0.78965019
113MP0004808_abnormal_hematopoietic_stem0.78456225
114MP0005397_hematopoietic_system_phenotyp0.76679500
115MP0001545_abnormal_hematopoietic_system0.76679500
116MP0005390_skeleton_phenotype0.75937047
117MP0005387_immune_system_phenotype0.75793030
118MP0001790_abnormal_immune_system0.75793030
119MP0000639_abnormal_adrenal_gland0.75047910
120MP0002277_abnormal_respiratory_mucosa0.73505555
121MP0001533_abnormal_skeleton_physiology0.73304421
122MP0005670_abnormal_white_adipose0.73090892
123MP0002136_abnormal_kidney_physiology0.72809378
124MP0000371_diluted_coat_color0.72752202
125MP0003075_altered_response_to0.71773183
126MP0009780_abnormal_chondrocyte_physiolo0.70828468
127MP0005395_other_phenotype0.70267833
128MP0000015_abnormal_ear_pigmentation0.69175811
129MP0009765_abnormal_xenobiotic_induced0.68350655
130MP0006054_spinal_hemorrhage0.68289547
131MP0005023_abnormal_wound_healing0.68013341
132MP0003795_abnormal_bone_structure0.67971144
133MP0005167_abnormal_blood-brain_barrier0.67248239
134MP0002060_abnormal_skin_morphology0.67217592
135MP0002168_other_aberrant_phenotype0.66150559
136MP0003045_fibrosis0.65298330
137MP0003453_abnormal_keratinocyte_physiol0.64135321
138MP0000465_gastrointestinal_hemorrhage0.63878678
139MP0002006_tumorigenesis0.63638847
140MP0003953_abnormal_hormone_level0.63094311
141MP0001663_abnormal_digestive_system0.61005247
142MP0001800_abnormal_humoral_immune0.60850522
143MP0001835_abnormal_antigen_presentation0.60790297
144MP0004130_abnormal_muscle_cell0.60437892
145MP0003186_abnormal_redox_activity0.59972861
146MP0001501_abnormal_sleep_pattern0.59419718
147MP0005025_abnormal_response_to0.59223258
148MP0010307_abnormal_tumor_latency0.58912842
149MP0005174_abnormal_tail_pigmentation0.58906500
150MP0003699_abnormal_female_reproductive0.58849367
151MP0001915_intracranial_hemorrhage0.58165027
152MP0009672_abnormal_birth_weight0.57778367
153MP0004782_abnormal_surfactant_physiolog0.57239324

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.90195707
2Eczematoid dermatitis (HP:0000976)5.57421528
3Intrahepatic cholestasis (HP:0001406)5.47201669
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.98783477
5Myositis (HP:0100614)4.93000239
6Stomatitis (HP:0010280)4.79472646
7T lymphocytopenia (HP:0005403)4.79468363
8Optic neuritis (HP:0100653)4.79443106
9Retrobulbar optic neuritis (HP:0100654)4.79443106
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.75464055
11Orchitis (HP:0100796)4.73587949
12Abnormality of the common coagulation pathway (HP:0010990)4.65647376
13Abnormality of T cell number (HP:0011839)4.60282456
14Complement deficiency (HP:0004431)4.47130011
15Prolonged partial thromboplastin time (HP:0003645)4.45456773
16Xanthomatosis (HP:0000991)4.36967144
17Abnormality of the intrinsic pathway (HP:0010989)4.33249919
18Recurrent bacterial skin infections (HP:0005406)4.18491923
19Hypoglycemic coma (HP:0001325)4.16265044
20Abnormal delayed hypersensitivity skin test (HP:0002963)4.10660069
21Recurrent abscess formation (HP:0002722)4.03749717
22Elevated erythrocyte sedimentation rate (HP:0003565)4.02814625
23Recurrent fungal infections (HP:0002841)3.89090122
24Abnormality of T cells (HP:0002843)3.79645907
25Abnormality of macrophages (HP:0004311)3.78884793
26Joint hemorrhage (HP:0005261)3.74660962
27Pustule (HP:0200039)3.74229920
28Hypobetalipoproteinemia (HP:0003563)3.60535105
29Hypoglycemic seizures (HP:0002173)3.55262894
30Mediastinal lymphadenopathy (HP:0100721)3.49953884
31Conjugated hyperbilirubinemia (HP:0002908)3.47374267
32Pulmonary infiltrates (HP:0002113)3.46641191
33Keratoconjunctivitis sicca (HP:0001097)3.46152559
34Vasculitis (HP:0002633)3.44848920
35Ketosis (HP:0001946)3.42146647
36Hyperinsulinemic hypoglycemia (HP:0000825)3.34194541
37Fat malabsorption (HP:0002630)3.33597049
38Abnormality of complement system (HP:0005339)3.31777024
39Recurrent viral infections (HP:0004429)3.31350543
40Hyperlipoproteinemia (HP:0010980)3.30959345
41Chronic mucocutaneous candidiasis (HP:0002728)3.30352714
42Recurrent cutaneous fungal infections (HP:0011370)3.30352714
43Keratoconjunctivitis (HP:0001096)3.26232550
44Myocardial infarction (HP:0001658)3.24450563
45Encephalitis (HP:0002383)3.24117016
46Hyperglycemia (HP:0003074)3.23560079
47Meningitis (HP:0001287)3.21885653
48Abnormality of T cell physiology (HP:0011840)3.20512171
49Increased IgE level (HP:0003212)3.18619243
50Abnormality of sulfur amino acid metabolism (HP:0004339)3.17077912
51IgG deficiency (HP:0004315)3.15552054
52Spontaneous hematomas (HP:0007420)3.14119324
53Recurrent skin infections (HP:0001581)3.13630768
54Epidermoid cyst (HP:0200040)3.06994701
55Ketoacidosis (HP:0001993)3.04627392
56Leukocytosis (HP:0001974)3.02757604
57Autoimmune hemolytic anemia (HP:0001890)2.95800799
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.95430883
59Hypolipoproteinemia (HP:0010981)2.95293524
60Panhypogammaglobulinemia (HP:0003139)2.93213840
61Abnormality of eosinophils (HP:0001879)2.92475587
62Hypoalphalipoproteinemia (HP:0003233)2.85612483
63Prolonged bleeding time (HP:0003010)2.84324999
64Inflammation of the large intestine (HP:0002037)2.81558147
65Granulocytopenia (HP:0001913)2.80428318
66Hemoptysis (HP:0002105)2.80405757
67Autoimmune thrombocytopenia (HP:0001973)2.80057213
68Mucopolysacchariduria (HP:0008155)2.76760716
69Urinary glycosaminoglycan excretion (HP:0003541)2.76760716
70Eosinophilia (HP:0001880)2.76356637
71Recurrent bronchitis (HP:0002837)2.73756545
72Menorrhagia (HP:0000132)2.73330520
73Joint swelling (HP:0001386)2.69986577
74Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.69881931
75Late onset (HP:0003584)2.69688249
76Increased IgM level (HP:0003496)2.69265630
77Severe combined immunodeficiency (HP:0004430)2.66558066
78Gingivitis (HP:0000230)2.65852888
79Abnormality of mucopolysaccharide metabolism (HP:0011020)2.65755638
80Abnormality of polysaccharide metabolism (HP:0011012)2.65755638
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.65755638
82Gastrointestinal inflammation (HP:0004386)2.64468607
83Hyperammonemia (HP:0001987)2.61965111
84Gingival bleeding (HP:0000225)2.60376299
85Gangrene (HP:0100758)2.58841410
86Colitis (HP:0002583)2.58653660
87Symptomatic seizures (HP:0011145)2.58566025
88Recurrent gram-negative bacterial infections (HP:0005420)2.57710503
89Systemic lupus erythematosus (HP:0002725)2.57173218
90Hypercholesterolemia (HP:0003124)2.57160497
91Abnormality of endocrine pancreas physiology (HP:0012093)2.56776049
92Abnormality of the pancreatic islet cells (HP:0006476)2.56776049
93Insulin-resistant diabetes mellitus (HP:0000831)2.53309336
94Skin nodule (HP:0200036)2.52278765
95Abnormality of purine metabolism (HP:0004352)2.51160773
96Chest pain (HP:0100749)2.50303483
97Obstructive lung disease (HP:0006536)2.48467335
98Chronic obstructive pulmonary disease (HP:0006510)2.48467335
99Hematochezia (HP:0002573)2.43112095
100Urticaria (HP:0001025)2.41721480
101Hyperglycinemia (HP:0002154)2.40817773
102Hepatocellular carcinoma (HP:0001402)2.39630603
103Anorexia (HP:0002039)2.39551053
104Esophageal varix (HP:0002040)2.38829851
105Chronic diarrhea (HP:0002028)2.35601169
106Abnormality of nucleobase metabolism (HP:0010932)2.35477515
107Hyperbilirubinemia (HP:0002904)2.34970309
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.34722351
109Dysostosis multiplex (HP:0000943)2.33678873
110Pancreatitis (HP:0001733)2.30704607
111Steatorrhea (HP:0002570)2.28429024
112Abnormality of methionine metabolism (HP:0010901)2.27023736
113Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.25849104
114Stomach cancer (HP:0012126)2.25333681
115IgM deficiency (HP:0002850)2.25224671
116Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25166116
117Hyperglycinuria (HP:0003108)2.25119780
118Lymphopenia (HP:0001888)2.24384732
119Glomerulonephritis (HP:0000099)2.22088140
120Mitral stenosis (HP:0001718)2.18831345
121Vacuolated lymphocytes (HP:0001922)2.18351675
122Episodic fever (HP:0001954)2.17604485
123Abnormality of cells of the lymphoid lineage (HP:0012140)2.16629920
124Acanthocytosis (HP:0001927)2.16259548
125Hypergammaglobulinemia (HP:0010702)2.15855174
126Verrucae (HP:0200043)2.15527741
127Papilloma (HP:0012740)2.15527741
128Pancreatic islet-cell hyperplasia (HP:0004510)2.13483478
129Hypochromic anemia (HP:0001931)2.13342251
130Thrombophlebitis (HP:0004418)2.13269223
131Agammaglobulinemia (HP:0004432)2.12489788
132Abnormality of the pleura (HP:0002103)2.10880547
133Abnormality of serine family amino acid metabolism (HP:0010894)2.09935284
134Abnormality of glycine metabolism (HP:0010895)2.09935284
135Papilledema (HP:0001085)2.08364608
136Insulin resistance (HP:0000855)2.07650794
137Combined immunodeficiency (HP:0005387)2.06094847
138Keratitis (HP:0000491)2.05200685
139Abnormality of the fingertips (HP:0001211)2.04417178
140Abnormality of pyrimidine metabolism (HP:0004353)2.04110998
141Abnormality of fatty-acid metabolism (HP:0004359)2.02342085
142Glomerulopathy (HP:0100820)2.02048792
143Hypochromic microcytic anemia (HP:0004840)2.00804620
144Increased cerebral lipofuscin (HP:0011813)2.00549640
145Gastrointestinal stroma tumor (HP:0100723)1.99209227
146Abnormal enzyme/coenzyme activity (HP:0012379)1.98942961
147Aneurysm (HP:0002617)1.98491273
148Arterial thrombosis (HP:0004420)1.97651588
149Spontaneous abortion (HP:0005268)1.96081383
150Prostate neoplasm (HP:0100787)1.95903514
151Elevated alkaline phosphatase (HP:0003155)1.95667148
152Abnormal platelet function (HP:0011869)1.95592634
153Impaired platelet aggregation (HP:0003540)1.95592634
154Malnutrition (HP:0004395)1.94497231
155Pulmonary embolism (HP:0002204)1.94371399
156Hemorrhage of the eye (HP:0011885)1.94261088
157Sensorimotor neuropathy (HP:0007141)1.94113589
158Peritonitis (HP:0002586)1.93710511
159Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93653182
160Abnormality of transition element cation homeostasis (HP:0011030)1.91739117
161Fatigue (HP:0012378)1.91090891
162Osteomyelitis (HP:0002754)1.89898612
163Abnormality of proline metabolism (HP:0010907)1.89700366
164Hydroxyprolinuria (HP:0003080)1.89700366
165Increased neuronal autofluorescent lipopigment (HP:0002074)1.89684924
166Neoplasm of the tracheobronchial system (HP:0100552)1.89186140
167Acne (HP:0001061)1.88625707
168Abnormality of the endocardium (HP:0004306)1.87515383
169Abnormality of alkaline phosphatase activity (HP:0004379)1.85602694
170Gout (HP:0001997)1.85185557
171Long toe (HP:0010511)1.84886809
172Viral hepatitis (HP:0006562)1.83549671
173Alveolar cell carcinoma (HP:0006519)1.83005047
174Abnormal gallbladder morphology (HP:0012437)1.82700058
175Thyroiditis (HP:0100646)1.82043044
176Amyloidosis (HP:0011034)1.80416284
177Epistaxis (HP:0000421)1.79251918
178Generalized aminoaciduria (HP:0002909)1.78943223
179Acute hepatic failure (HP:0006554)1.78551663
180Abnormality of liposaccharide metabolism (HP:0010968)1.77922511
181Abnormality of glycosphingolipid metabolism (HP:0004343)1.77922511
182Abnormality of glycolipid metabolism (HP:0010969)1.77922511
183Abnormality of the prostate (HP:0008775)1.77890946
184Arthralgia (HP:0002829)1.77490604
185Spastic diplegia (HP:0001264)1.75534123
186Cortical dysplasia (HP:0002539)1.74717731
187Periodontitis (HP:0000704)1.74576471
188Tetraparesis (HP:0002273)1.72962845
189Increased mean platelet volume (HP:0011877)1.69431186
190Gastrointestinal infarctions (HP:0005244)1.69157368
191Abnormality of iron homeostasis (HP:0011031)1.68360073
192Cholelithiasis (HP:0001081)1.67699569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.48043360
2LATS13.17402462
3INSRR3.09034196
4RIPK43.01144295
5TRIB32.96596996
6IRAK32.58387126
7GRK62.56555291
8PKN22.50507916
9SIK12.45877357
10EEF2K2.40944636
11PRPF4B2.39889158
12FRK2.36148175
13FGFR42.21352950
14BCKDK2.18611445
15FLT32.07494296
16PTK62.06028019
17FES1.98739052
18BLK1.98644541
19TNK21.88674626
20JAK11.74798750
21IKBKB1.63341638
22EPHB11.61037449
23TYK21.56395965
24CDK121.52291456
25SYK1.51667445
26PIK3CG1.51592587
27JAK31.43883096
28CAMK1D1.43402220
29EPHA31.41283677
30AKT31.40367791
31HIPK21.39906977
32JAK21.37960850
33TBK11.35711414
34CAMK1G1.32803389
35ERBB41.31184230
36STK31.30939066
37SIK31.30196666
38MAP3K61.27064208
39MAP3K21.27034554
40LCK1.26042380
41IRAK11.22084460
42MARK31.20481643
43RIPK11.19755431
44NEK91.19154545
45MAP2K21.15308397
46STK101.14585983
47MAPK151.14115531
48FGR1.13940817
49MAP4K11.12318056
50LYN1.11903163
51MATK1.07154513
52MAPK71.04653781
53FGFR31.04051501
54MAP2K31.03336230
55RET1.02961596
56PDGFRA1.02010402
57MAP3K101.01592651
58MTOR1.01229153
59ZAP701.01144077
60* TAOK31.01042765
61MAPKAPK31.00676596
62MAP3K10.98323223
63CDK60.98122971
64MAP3K140.96933159
65PTK20.94906771
66PASK0.94816373
67MST1R0.94383449
68MARK20.94234078
69SCYL20.93040986
70MAP3K30.92640017
71MAP3K70.91590740
72PDK10.90419045
73LRRK20.89572490
74TAOK10.89531160
75PRKAA20.87369333
76BTK0.87197909
77MOS0.84656575
78SIK20.84603766
79MAPK110.83770708
80CDK90.83126458
81KIT0.81960226
82CHUK0.81923402
83TGFBR20.81883678
84NUAK10.80711080
85MAP3K110.80079814
86IRAK20.79785420
87MAPK120.79110874
88CDC42BPA0.76570365
89ITK0.75199982
90MAP3K130.74665717
91PRKCQ0.72463919
92PRKAA10.71713023
93IKBKE0.71498349
94SGK30.70105577
95YES10.69965299
96MELK0.67566501
97TEC0.66516670
98PDGFRB0.66463379
99TTN0.64105604
100NLK0.63878019
101TAOK20.63371194
102GRK70.62748749
103GSK3A0.62277254
104TXK0.60477097
105STK380.58840665
106BRD40.58809967
107PRKCH0.58069944
108SGK20.58047413
109CAMKK20.53036395
110BMX0.52903309
111MAP2K60.51999925
112MAP3K80.49995294
113KSR20.49636243
114WNK10.49420145
115MET0.48838298
116IRAK40.48446259
117BMPR20.48383146
118CSF1R0.47889205
119PTK2B0.47576572
120CSK0.46901323
121CDK40.46571078
122DYRK1B0.46490990
123PAK20.46115948
124PIK3CA0.45630803
125PIM10.45066379
126PRKD20.44314391
127HCK0.44117978
128RPS6KC10.43479577
129RPS6KL10.43479577
130RPS6KA60.43237657
131RPS6KA40.42874754
132ACVR1B0.42305305
133PDPK10.42192481
134RPS6KB20.41658857
135MAPKAPK20.41583681
136TRPM70.39468928
137ABL10.39359549
138ERBB20.38399484
139IGF1R0.35737967
140EGFR0.35203160
141DMPK0.34696818

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.70088159
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.37342947
3Nitrogen metabolism_Homo sapiens_hsa009103.31369553
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.05182555
5Primary immunodeficiency_Homo sapiens_hsa053402.89829658
6Complement and coagulation cascades_Homo sapiens_hsa046102.72494955
7Arginine biosynthesis_Homo sapiens_hsa002202.45822998
8T cell receptor signaling pathway_Homo sapiens_hsa046602.42604730
9Tryptophan metabolism_Homo sapiens_hsa003802.42215249
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32841879
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.23992826
12Graft-versus-host disease_Homo sapiens_hsa053322.20434211
13B cell receptor signaling pathway_Homo sapiens_hsa046622.10677674
14Allograft rejection_Homo sapiens_hsa053302.07317274
15Staphylococcus aureus infection_Homo sapiens_hsa051502.04834468
16Fatty acid degradation_Homo sapiens_hsa000712.03052690
17Selenocompound metabolism_Homo sapiens_hsa004502.02846441
18Caffeine metabolism_Homo sapiens_hsa002322.01687030
19Measles_Homo sapiens_hsa051622.01301530
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96659495
21Autoimmune thyroid disease_Homo sapiens_hsa053201.95228691
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91957913
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.90261486
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89092482
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85950636
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83159941
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79195217
28ABC transporters_Homo sapiens_hsa020101.73152799
29Sulfur metabolism_Homo sapiens_hsa009201.72272456
30Hematopoietic cell lineage_Homo sapiens_hsa046401.64738109
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61924298
32Malaria_Homo sapiens_hsa051441.61540466
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60193871
34Histidine metabolism_Homo sapiens_hsa003401.56707583
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54231877
36Tuberculosis_Homo sapiens_hsa051521.53958751
37Lysine degradation_Homo sapiens_hsa003101.50962924
38* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50620795
39PPAR signaling pathway_Homo sapiens_hsa033201.50410693
40Chemokine signaling pathway_Homo sapiens_hsa040621.47238249
41Influenza A_Homo sapiens_hsa051641.46828972
42Starch and sucrose metabolism_Homo sapiens_hsa005001.46719271
43Fat digestion and absorption_Homo sapiens_hsa049751.44151004
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.43299138
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43254303
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42467215
47Type I diabetes mellitus_Homo sapiens_hsa049401.42426498
48Peroxisome_Homo sapiens_hsa041461.42301555
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.41082772
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34833683
51Bile secretion_Homo sapiens_hsa049761.33817900
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33679902
53Herpes simplex infection_Homo sapiens_hsa051681.32664361
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31972067
55Legionellosis_Homo sapiens_hsa051341.26010640
56Non-small cell lung cancer_Homo sapiens_hsa052231.25450789
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24563444
58Folate biosynthesis_Homo sapiens_hsa007901.23600778
59Chemical carcinogenesis_Homo sapiens_hsa052041.22448626
60Hepatitis B_Homo sapiens_hsa051611.22341303
61beta-Alanine metabolism_Homo sapiens_hsa004101.20410713
62Butanoate metabolism_Homo sapiens_hsa006501.17932464
63Retinol metabolism_Homo sapiens_hsa008301.17454061
64Fatty acid metabolism_Homo sapiens_hsa012121.17406322
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.11922322
66Insulin resistance_Homo sapiens_hsa049311.11741034
67Propanoate metabolism_Homo sapiens_hsa006401.10886394
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10607382
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06799414
70Pertussis_Homo sapiens_hsa051331.02252480
71Platelet activation_Homo sapiens_hsa046111.01114328
72Viral myocarditis_Homo sapiens_hsa054161.00342866
73Asthma_Homo sapiens_hsa053100.98021499
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93905812
75African trypanosomiasis_Homo sapiens_hsa051430.93138145
76* Apoptosis_Homo sapiens_hsa042100.92638402
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92478556
78VEGF signaling pathway_Homo sapiens_hsa043700.90758821
79Other glycan degradation_Homo sapiens_hsa005110.88262839
80Tyrosine metabolism_Homo sapiens_hsa003500.87452425
81Rheumatoid arthritis_Homo sapiens_hsa053230.86726438
82Phenylalanine metabolism_Homo sapiens_hsa003600.84983148
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.83443042
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80577283
85Renal cell carcinoma_Homo sapiens_hsa052110.78703945
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78433585
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.77268113
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.76643452
89Type II diabetes mellitus_Homo sapiens_hsa049300.76614192
90One carbon pool by folate_Homo sapiens_hsa006700.72939486
91Circadian rhythm_Homo sapiens_hsa047100.71559068
92Glycerolipid metabolism_Homo sapiens_hsa005610.71320351
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.70284477
94Lysosome_Homo sapiens_hsa041420.69926439
95Vitamin digestion and absorption_Homo sapiens_hsa049770.68917457
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68177355
97Inositol phosphate metabolism_Homo sapiens_hsa005620.65645239
98Choline metabolism in cancer_Homo sapiens_hsa052310.64409602
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.63393158
100Pyruvate metabolism_Homo sapiens_hsa006200.61268600
101Protein export_Homo sapiens_hsa030600.60858269
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60638112
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60050410
104Biosynthesis of amino acids_Homo sapiens_hsa012300.59514071
105N-Glycan biosynthesis_Homo sapiens_hsa005100.59159691
106Epstein-Barr virus infection_Homo sapiens_hsa051690.59150638
107Endometrial cancer_Homo sapiens_hsa052130.58872335
108Arginine and proline metabolism_Homo sapiens_hsa003300.58699173
109Prolactin signaling pathway_Homo sapiens_hsa049170.58329412
110Prostate cancer_Homo sapiens_hsa052150.57983689
111Viral carcinogenesis_Homo sapiens_hsa052030.57629267
112MAPK signaling pathway_Homo sapiens_hsa040100.56754085
113Shigellosis_Homo sapiens_hsa051310.56488229
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56184050
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54828115
116Ovarian steroidogenesis_Homo sapiens_hsa049130.53640118
117HTLV-I infection_Homo sapiens_hsa051660.52564145
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.51689451
119Endocytosis_Homo sapiens_hsa041440.49910949
120Arachidonic acid metabolism_Homo sapiens_hsa005900.49331023
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49280374
122GnRH signaling pathway_Homo sapiens_hsa049120.47799586
123Prion diseases_Homo sapiens_hsa050200.47385798
124Osteoclast differentiation_Homo sapiens_hsa043800.47369273
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47256078
126Vitamin B6 metabolism_Homo sapiens_hsa007500.46722196
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46717150
128Galactose metabolism_Homo sapiens_hsa000520.46386264
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45578961
130Phagosome_Homo sapiens_hsa041450.45279565
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45204850
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45096885
133Carbon metabolism_Homo sapiens_hsa012000.44502621
134ErbB signaling pathway_Homo sapiens_hsa040120.44079216
135Chronic myeloid leukemia_Homo sapiens_hsa052200.43820373
136Sulfur relay system_Homo sapiens_hsa041220.43603978
137Pancreatic cancer_Homo sapiens_hsa052120.43161950
138Notch signaling pathway_Homo sapiens_hsa043300.42861952
139Steroid biosynthesis_Homo sapiens_hsa001000.42562071
140Salmonella infection_Homo sapiens_hsa051320.41869621
141Glucagon signaling pathway_Homo sapiens_hsa049220.41780293
142mTOR signaling pathway_Homo sapiens_hsa041500.41551372
143AMPK signaling pathway_Homo sapiens_hsa041520.40279555
144NF-kappa B signaling pathway_Homo sapiens_hsa040640.39631843
145HIF-1 signaling pathway_Homo sapiens_hsa040660.39610616
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39014560
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38835662
148Colorectal cancer_Homo sapiens_hsa052100.38748951
149alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38167379
150Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37566423
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37534292
152Cyanoamino acid metabolism_Homo sapiens_hsa004600.37190296
153Acute myeloid leukemia_Homo sapiens_hsa052210.37033969
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.36926497
155Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34044513
156TNF signaling pathway_Homo sapiens_hsa046680.33932397
157Insulin signaling pathway_Homo sapiens_hsa049100.33487204
158Toxoplasmosis_Homo sapiens_hsa051450.32655950
159Jak-STAT signaling pathway_Homo sapiens_hsa046300.32568484
160Leishmaniasis_Homo sapiens_hsa051400.28233445
161Antigen processing and presentation_Homo sapiens_hsa046120.28076406
162Hepatitis C_Homo sapiens_hsa051600.27974365
163Bladder cancer_Homo sapiens_hsa052190.26953205
164Linoleic acid metabolism_Homo sapiens_hsa005910.26277089
165Glutathione metabolism_Homo sapiens_hsa004800.26096003
166Dorso-ventral axis formation_Homo sapiens_hsa043200.26086329
167Pentose phosphate pathway_Homo sapiens_hsa000300.25948703
168FoxO signaling pathway_Homo sapiens_hsa040680.25229736
169Amoebiasis_Homo sapiens_hsa051460.25059762

Most similar genes based on co-expression Upload to Enrichr

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