ERN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.96107699
2cilium movement (GO:0003341)8.53029507
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.12425183
4epithelial cilium movement (GO:0003351)7.88036022
5motile cilium assembly (GO:0044458)7.33710565
6axoneme assembly (GO:0035082)7.03800137
7positive regulation of prostaglandin secretion (GO:0032308)6.94177058
8maintenance of gastrointestinal epithelium (GO:0030277)6.62612698
9carnitine shuttle (GO:0006853)6.06327195
10flavonoid metabolic process (GO:0009812)5.95505769
11regulation of prostaglandin secretion (GO:0032306)5.90953964
12intestinal absorption (GO:0050892)5.79447758
13fatty acid homeostasis (GO:0055089)5.78079211
14negative regulation of cholesterol transport (GO:0032375)5.72783847
15negative regulation of sterol transport (GO:0032372)5.72783847
16intestinal epithelial cell development (GO:0060576)5.70392376
17purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.57625094
183-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.57625094
19positive regulation of macrophage derived foam cell differentiation (GO:0010744)5.52289525
20sulfation (GO:0051923)5.24831410
21positive regulation of icosanoid secretion (GO:0032305)5.18884439
22phosphatidylserine acyl-chain remodeling (GO:0036150)5.15611107
23primary alcohol catabolic process (GO:0034310)5.12821439
24bundle of His cell to Purkinje myocyte communication (GO:0086069)5.06360288
25phosphatidylinositol acyl-chain remodeling (GO:0036149)5.02775255
26sulfur amino acid catabolic process (GO:0000098)4.99995110
27epithelial structure maintenance (GO:0010669)4.97829333
28fatty acid transmembrane transport (GO:1902001)4.94165712
29regulation of energy homeostasis (GO:2000505)4.90922419
30regulation of cilium movement (GO:0003352)4.86679222
31ethanol metabolic process (GO:0006067)4.84054413
32positive regulation of glycolytic process (GO:0045821)4.76279017
33cellular glucuronidation (GO:0052695)4.68600368
34histone-serine phosphorylation (GO:0035404)4.68429256
35diterpenoid biosynthetic process (GO:0016102)4.55045158
36ethanol oxidation (GO:0006069)4.53744331
37phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.53405257
38carnitine transmembrane transport (GO:1902603)4.51747369
39exogenous drug catabolic process (GO:0042738)4.44349907
40positive regulation of fatty acid transport (GO:2000193)4.33872953
41glucuronate metabolic process (GO:0019585)4.32044431
42uronic acid metabolic process (GO:0006063)4.32044431
43bile acid and bile salt transport (GO:0015721)4.24807091
44UDP-N-acetylglucosamine metabolic process (GO:0006047)4.23386713
45amino-acid betaine transport (GO:0015838)4.23074040
46carnitine transport (GO:0015879)4.23074040
47positive regulation of respiratory burst (GO:0060267)4.16676960
48drug catabolic process (GO:0042737)4.15929390
49bicarbonate transport (GO:0015701)4.14128153
50left/right pattern formation (GO:0060972)4.10723307
51ATP synthesis coupled proton transport (GO:0015986)4.07793985
52energy coupled proton transport, down electrochemical gradient (GO:0015985)4.07793985
53digestive system process (GO:0022600)4.06623968
54left/right axis specification (GO:0070986)4.05253006
55pyrimidine-containing compound transmembrane transport (GO:0072531)4.04488534
56cellular response to glucose starvation (GO:0042149)4.03336179
57phosphatidylserine metabolic process (GO:0006658)4.02929468
58negative regulation of T cell differentiation in thymus (GO:0033085)4.02606009
59glucocorticoid biosynthetic process (GO:0006704)4.02366925
60phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.00983899
61sulfate transmembrane transport (GO:1902358)4.00584789
62cellular ketone body metabolic process (GO:0046950)3.99361900
63positive regulation of pseudopodium assembly (GO:0031274)3.98018545
64O-glycan processing (GO:0016266)3.97850043
65cilium organization (GO:0044782)3.96839197
66calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.96403424
67negative regulation of protein oligomerization (GO:0032460)3.93874897
68regulation of guanylate cyclase activity (GO:0031282)3.91701063
69intraciliary transport (GO:0042073)3.88949702
70one-carbon compound transport (GO:0019755)3.84127506
71cilium assembly (GO:0042384)3.83549912
72nucleotide transmembrane transport (GO:1901679)3.79125506
73oligosaccharide biosynthetic process (GO:0009312)3.77440706
74regulation of icosanoid secretion (GO:0032303)3.76755405
75microtubule bundle formation (GO:0001578)3.72105028
76renal system process involved in regulation of blood volume (GO:0001977)3.71375739
77digestion (GO:0007586)3.66222687
78sperm capacitation (GO:0048240)3.63846943
79galactose catabolic process (GO:0019388)3.62784341
80terpenoid biosynthetic process (GO:0016114)3.61471274
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.60359390
82transcytosis (GO:0045056)3.57936846
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.54485193
84regulation of pseudopodium assembly (GO:0031272)3.53439077
85response to food (GO:0032094)3.50283153
86protein localization to cilium (GO:0061512)3.49030659
87retinoic acid metabolic process (GO:0042573)3.47962348
88fucosylation (GO:0036065)3.46141014
89ketone body metabolic process (GO:1902224)3.43716132
90respiratory tube development (GO:0030323)3.40745999
91retinol metabolic process (GO:0042572)3.40206912
92ATP biosynthetic process (GO:0006754)3.39986726
93lung secretory cell differentiation (GO:0061140)3.34243227
94intestinal cholesterol absorption (GO:0030299)3.32200358
95primary alcohol metabolic process (GO:0034308)3.32115900
96excretion (GO:0007588)3.27829131
97alditol phosphate metabolic process (GO:0052646)3.26630117
98vitamin transmembrane transport (GO:0035461)3.24375755
99respiratory electron transport chain (GO:0022904)3.24265802
100fucose catabolic process (GO:0019317)3.22386869
101L-fucose metabolic process (GO:0042354)3.22386869
102L-fucose catabolic process (GO:0042355)3.22386869
103cilium morphogenesis (GO:0060271)3.19888109
104electron transport chain (GO:0022900)3.15022997
105phosphatidylcholine acyl-chain remodeling (GO:0036151)3.13956423
106positive regulation of lipid storage (GO:0010884)3.13955003
107sulfate transport (GO:0008272)3.12603967
108regulation of microtubule-based movement (GO:0060632)3.10683405
109actin filament depolymerization (GO:0030042)3.09198164
110ventricular system development (GO:0021591)3.06060380
111drug metabolic process (GO:0017144)3.04366586
112positive regulation of guanylate cyclase activity (GO:0031284)3.03786587
113protein O-linked glycosylation (GO:0006493)3.03696285
114lung epithelium development (GO:0060428)2.99373267
115renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.97872199
116detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.97168815
117glandular epithelial cell differentiation (GO:0002067)2.95855032
118regulation of cGMP biosynthetic process (GO:0030826)2.95601882
119epoxygenase P450 pathway (GO:0019373)2.93979779
120cellular component assembly involved in morphogenesis (GO:0010927)2.93946538
121quaternary ammonium group transport (GO:0015697)2.93897226
122phospholipid transport (GO:0015914)2.91662174
123antibacterial humoral response (GO:0019731)2.90518527
124positive regulation of systemic arterial blood pressure (GO:0003084)2.90023094
125regulation of cholesterol efflux (GO:0010874)2.89630005
126phosphatidylcholine biosynthetic process (GO:0006656)2.89074569
127neurotransmitter biosynthetic process (GO:0042136)2.86266023
128photoreceptor cell maintenance (GO:0045494)2.85310290
129hepatocyte apoptotic process (GO:0097284)2.82655845
130intracellular lipid transport (GO:0032365)2.82653889
131cell projection assembly (GO:0030031)2.82296681
132striated muscle atrophy (GO:0014891)2.82162176
133sulfur compound transport (GO:0072348)2.81770552
134alkaloid metabolic process (GO:0009820)2.80525674
135desmosome organization (GO:0002934)2.79571096
136regulation of respiratory burst (GO:0060263)2.79436267
137epithelial cell-cell adhesion (GO:0090136)2.79434281
138antimicrobial humoral response (GO:0019730)2.79338673
139thrombin receptor signaling pathway (GO:0070493)2.75639928
140glutathione derivative metabolic process (GO:1901685)2.75327176
141glutathione derivative biosynthetic process (GO:1901687)2.75327176
142thyroid hormone metabolic process (GO:0042403)2.75229058
143glutathione biosynthetic process (GO:0006750)2.74875755
144phosphatidic acid biosynthetic process (GO:0006654)2.73561889
145phosphatidic acid metabolic process (GO:0046473)2.73561889
146sodium ion homeostasis (GO:0055078)2.73282178
147regulation of macrophage derived foam cell differentiation (GO:0010743)2.72314977
148endocrine process (GO:0050886)2.71351253
149water-soluble vitamin biosynthetic process (GO:0042364)2.71079671
150transepithelial transport (GO:0070633)2.68895163
151response to xenobiotic stimulus (GO:0009410)2.67927221
152neurotransmitter metabolic process (GO:0042133)2.67691062
153regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.61865339
154nonribosomal peptide biosynthetic process (GO:0019184)2.61637514
155auditory receptor cell differentiation (GO:0042491)2.59105414
156sperm motility (GO:0030317)2.58150061
157quinone biosynthetic process (GO:1901663)2.57888946
158tolerance induction (GO:0002507)2.56219673
159vitamin transport (GO:0051180)2.51753138
160centriole assembly (GO:0098534)2.49322052
161aldehyde catabolic process (GO:0046185)2.48607894
162cornea development in camera-type eye (GO:0061303)2.47013820
163phenol-containing compound catabolic process (GO:0019336)2.46296393
164axonemal dynein complex assembly (GO:0070286)11.2919012

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.53019183
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.06710659
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.41606391
4CDX2_19796622_ChIP-Seq_MESCs_Mouse2.84375399
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.63484926
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61511747
7SOX2_20726797_ChIP-Seq_SW620_Human2.56888596
8ZNF274_21170338_ChIP-Seq_K562_Hela2.37547031
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30905981
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26707493
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26282199
12GATA4_25053715_ChIP-Seq_YYC3_Human2.21669782
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20862204
14* GATA6_25053715_ChIP-Seq_YYC3_Human2.12829090
15VDR_22108803_ChIP-Seq_LS180_Human2.12608845
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.09155231
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.06309939
18ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.05012749
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.04062819
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.03859548
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00489687
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91062258
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.88716503
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85508611
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.85114297
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80073970
27PPARA_22158963_ChIP-Seq_LIVER_Mouse1.74642351
28NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.72254172
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.72146630
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.70234464
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70006696
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.64132820
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64047343
34KLF5_25053715_ChIP-Seq_YYC3_Human1.63974128
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.60526602
36RACK7_27058665_Chip-Seq_MCF-7_Human1.59505560
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57998276
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57258769
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55822817
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55533552
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55398338
42FOXA1_25329375_ChIP-Seq_VCAP_Human1.54605152
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.54605152
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52672476
45RUNX1_27514584_Chip-Seq_MCF-7_Human1.44922270
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44893519
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43559796
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42626891
49AR_20517297_ChIP-Seq_VCAP_Human1.42417292
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42070923
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.40543025
52ER_23166858_ChIP-Seq_MCF-7_Human1.40368773
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.37822076
54ZNF263_19887448_ChIP-Seq_K562_Human1.37525970
55AHR_22903824_ChIP-Seq_MCF-7_Human1.37451776
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33979892
57* NANOG_20526341_ChIP-Seq_ESCs_Human1.33229143
58CEBPB_22108803_ChIP-Seq_LS180_Human1.32216229
59TCF4_22108803_ChIP-Seq_LS180_Human1.31359220
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.30295456
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.29407038
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29281818
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28782087
64FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.28559322
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28241804
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.28203435
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27685005
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.27135688
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26662033
70EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.26388551
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26055460
72FOXA1_25552417_ChIP-Seq_VCAP_Human1.25338607
73NCOR_22424771_ChIP-Seq_293T_Human1.25212112
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.24996057
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24216719
76ETV1_20927104_ChIP-Seq_GIST48_Human1.24183566
77DROSHA_22980978_ChIP-Seq_HELA_Human1.24120211
78MYC_19829295_ChIP-Seq_ESCs_Human1.23730456
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22765442
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21458997
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.20343768
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19054172
83ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17999576
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17238590
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16947710
86RBPJ_21746931_ChIP-Seq_IB4_Human1.16769322
87TAF2_19829295_ChIP-Seq_ESCs_Human1.15655795
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.15067478
89ERA_21632823_ChIP-Seq_H3396_Human1.14927351
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13541779
91P53_21459846_ChIP-Seq_SAOS-2_Human1.13396208
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13227085
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12483014
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11943673
95LXR_22292898_ChIP-Seq_THP-1_Human1.11421855
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10921206
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.10906119
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10489577
99CBP_20019798_ChIP-Seq_JUKART_Human1.10489577
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.10471550
101PHF8_20622853_ChIP-Seq_HELA_Human1.10456794
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09985061
103HOXB7_26014856_ChIP-Seq_BT474_Human1.09722483
104STAT3_23295773_ChIP-Seq_U87_Human1.09388436
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08356795
106SOX2_19829295_ChIP-Seq_ESCs_Human1.08234916
107NANOG_19829295_ChIP-Seq_ESCs_Human1.08234916
108HNFA_21074721_ChIP-Seq_CACO-2_Human1.07941426
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07718855
110AR_25329375_ChIP-Seq_VCAP_Human1.07447388
111RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07366340
112E2F1_20622854_ChIP-Seq_HELA_Human1.07249909
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06860476
114GBX2_23144817_ChIP-Seq_PC3_Human1.06777599
115IGF1R_20145208_ChIP-Seq_DFB_Human1.06697159
116TCF4_23295773_ChIP-Seq_U87_Human1.04940479
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04836474
118SMRT_27268052_Chip-Seq_Bcells_Human1.04412509
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03948623
120CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03496618
121OCT4_20526341_ChIP-Seq_ESCs_Human1.02913587
122TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02520191
123CREB1_26743006_Chip-Seq_LNCaP_Human1.01971385
124FOXH1_21741376_ChIP-Seq_ESCs_Human1.01680461
125ATF3_27146783_Chip-Seq_COLON_Human1.01303754
126NFYA_21822215_ChIP-Seq_K562_Human1.00429346
127SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99945495
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99331046
129KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99196311
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98929399
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98618124
132MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98307140
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.97950950
134TP63_23658742_ChIP-Seq_EP156T_Human0.97888434
135* SMAD4_21799915_ChIP-Seq_A2780_Human0.97714213
136GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96999125
137BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96640961
138* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96579141
139RXR_22108803_ChIP-Seq_LS180_Human0.95969029
140JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95747125
141EZH2_27294783_Chip-Seq_ESCs_Mouse0.94464360
142CTCF_27219007_Chip-Seq_Bcells_Human0.94430833
143BCAT_22108803_ChIP-Seq_LS180_Human0.94253611
144FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92431320
145STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92371319
146JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91953183
147* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91688306
148TCF4_18268006_ChIP-ChIP_LS174T_Human0.91669960
149GATA3_24758297_ChIP-Seq_MCF-7_Human0.91540239
150PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90814715
151SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90664602
152SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89828917
153ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89760133
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.89564278
155SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89122334
156GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87838762
157RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87010580
158CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86898941
159SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86271512
160CDX2_22108803_ChIP-Seq_LS180_Human0.86083400
161STAT1_20625510_ChIP-Seq_HELA_Human0.85977592
162OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84400262
163EGR1_19032775_ChIP-ChIP_M12_Human0.81600386
164GATA2_19941826_ChIP-Seq_K562_Human0.81102306
165PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81100783
166VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79047852
167SUZ12_27294783_Chip-Seq_ESCs_Mouse0.78389950
168VDR_24763502_ChIP-Seq_THP-1_Human0.77448490
169EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.76901840
170SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76030196
171SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76030196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH5.17775488
2MP0010234_abnormal_vibrissa_follicle4.16074252
3MP0004264_abnormal_extraembryonic_tissu4.07066330
4MP0001873_stomach_inflammation3.85661854
5MP0000537_abnormal_urethra_morphology3.73220756
6MP0001664_abnormal_digestion3.65282647
7MP0003866_abnormal_defecation3.46520870
8MP0001666_abnormal_nutrient_absorption3.21858933
9MP0000462_abnormal_digestive_system3.20628417
10MP0001663_abnormal_digestive_system3.02103857
11MP0005377_hearing/vestibular/ear_phenot3.01897330
12MP0003878_abnormal_ear_physiology3.01897330
13MP0005360_urolithiasis2.97108477
14MP0005381_digestive/alimentary_phenotyp2.80324173
15MP0002909_abnormal_adrenal_gland2.77495400
16* MP0010155_abnormal_intestine_physiology2.52670655
17MP0000477_abnormal_intestine_morphology2.51973367
18MP0002653_abnormal_ependyma_morphology2.48536036
19MP0005367_renal/urinary_system_phenotyp2.46142834
20MP0000516_abnormal_urinary_system2.46142834
21MP0009780_abnormal_chondrocyte_physiolo2.36528224
22MP0000490_abnormal_crypts_of2.28212835
23MP0003252_abnormal_bile_duct2.27891319
24MP0005085_abnormal_gallbladder_physiolo2.25343368
25MP0004484_altered_response_of2.21749351
26MP0003283_abnormal_digestive_organ2.13688909
27MP0002822_catalepsy2.11295709
28MP0003300_gastrointestinal_ulcer2.10589222
29MP0004043_abnormal_pH_regulation2.08923648
30MP0004147_increased_porphyrin_level2.06050207
31MP0003195_calcinosis2.05652572
32MP0003879_abnormal_hair_cell2.01583870
33MP0004130_abnormal_muscle_cell2.00347307
34MP0000470_abnormal_stomach_morphology1.97767403
35MP0008875_abnormal_xenobiotic_pharmacok1.93252182
36MP0001485_abnormal_pinna_reflex1.87092213
37MP0004133_heterotaxia1.85906857
38MP0003315_abnormal_perineum_morphology1.82348654
39MP0005551_abnormal_eye_electrophysiolog1.71070239
40MP0001984_abnormal_olfaction1.70291345
41MP0006276_abnormal_autonomic_nervous1.68505930
42MP0003806_abnormal_nucleotide_metabolis1.68326621
43MP0003868_abnormal_feces_composition1.67075289
44MP0000566_synostosis1.65122796
45MP0001849_ear_inflammation1.64536401
46MP0000538_abnormal_urinary_bladder1.63449633
47MP0003705_abnormal_hypodermis_morpholog1.59255652
48MP0005166_decreased_susceptibility_to1.51650998
49MP0005083_abnormal_biliary_tract1.48775100
50MP0005266_abnormal_metabolism1.46423784
51MP0006082_CNS_inflammation1.45557555
52MP0000383_abnormal_hair_follicle1.39781150
53MP0010352_gastrointestinal_tract_polyps1.32514747
54MP0002160_abnormal_reproductive_system1.31817594
55MP0000467_abnormal_esophagus_morphology1.31161196
56MP0001440_abnormal_grooming_behavior1.27217415
57MP0005365_abnormal_bile_salt1.27025982
58MP0005645_abnormal_hypothalamus_physiol1.24935998
59MP0002796_impaired_skin_barrier1.23976097
60MP0005332_abnormal_amino_acid1.20274578
61MP0005451_abnormal_body_composition1.20162269
62MP0002138_abnormal_hepatobiliary_system1.18854906
63MP0002638_abnormal_pupillary_reflex1.17639757
64MP0002136_abnormal_kidney_physiology1.17361822
65MP0005448_abnormal_energy_balance1.16979989
66MP0005187_abnormal_penis_morphology1.15441477
67MP0001765_abnormal_ion_homeostasis1.12310043
68MP0001188_hyperpigmentation1.11096810
69MP0001764_abnormal_homeostasis1.09505699
70MP0009643_abnormal_urine_homeostasis1.08127688
71MP0003075_altered_response_to1.07473196
72MP0005636_abnormal_mineral_homeostasis1.07033691
73MP0002139_abnormal_hepatobiliary_system1.05454458
74MP0002254_reproductive_system_inflammat1.04685607
75MP0001986_abnormal_taste_sensitivity1.03857622
76MP0005389_reproductive_system_phenotype1.03302980
77MP0000465_gastrointestinal_hemorrhage1.02537919
78MP0000427_abnormal_hair_cycle1.01456177
79MP0003718_maternal_effect0.98291791
80MP0006072_abnormal_retinal_apoptosis0.97526356
81MP0002736_abnormal_nociception_after0.97136216
82MP0003183_abnormal_peptide_metabolism0.94548949
83MP0010678_abnormal_skin_adnexa0.93796075
84MP0005646_abnormal_pituitary_gland0.92852347
85MP0005253_abnormal_eye_physiology0.92618706
86MP0005167_abnormal_blood-brain_barrier0.92346430
87MP0008789_abnormal_olfactory_epithelium0.92199205
88MP0009379_abnormal_foot_pigmentation0.91947944
89MP0005165_increased_susceptibility_to0.91794661
90MP0005174_abnormal_tail_pigmentation0.91500334
91MP0002277_abnormal_respiratory_mucosa0.89521479
92MP0001970_abnormal_pain_threshold0.86788901
93MP0004019_abnormal_vitamin_homeostasis0.86781148
94MP0000678_abnormal_parathyroid_gland0.86058679
95MP0009384_cardiac_valve_regurgitation0.85177026
96MP0002693_abnormal_pancreas_physiology0.84689267
97MP0003011_delayed_dark_adaptation0.83863941
98MP0003136_yellow_coat_color0.82465137
99MP0010386_abnormal_urinary_bladder0.82372866
100MP0004270_analgesia0.82232004
101MP0002168_other_aberrant_phenotype0.81139479
102MP0004885_abnormal_endolymph0.79589952
103MP0009840_abnormal_foam_cell0.77953261
104MP0005395_other_phenotype0.77465529
105MP0002837_dystrophic_cardiac_calcinosis0.76500071
106MP0005501_abnormal_skin_physiology0.75317755
107MP0001502_abnormal_circadian_rhythm0.75294479
108MP0002229_neurodegeneration0.75165386
109MP0000631_abnormal_neuroendocrine_gland0.74324224
110MP0001501_abnormal_sleep_pattern0.74139853
111MP0005376_homeostasis/metabolism_phenot0.73369585
112MP0004782_abnormal_surfactant_physiolog0.72834385
113MP0002102_abnormal_ear_morphology0.72603523
114MP0002118_abnormal_lipid_homeostasis0.71691118
115MP0002098_abnormal_vibrissa_morphology0.71106970
116MP0010329_abnormal_lipoprotein_level0.70748415
117MP0009046_muscle_twitch0.70472628
118MP0000026_abnormal_inner_ear0.68558962
119MP0004185_abnormal_adipocyte_glucose0.66545625
120MP0003453_abnormal_keratinocyte_physiol0.65941510
121MP0009745_abnormal_behavioral_response0.65700044
122MP0001944_abnormal_pancreas_morphology0.65660437
123MP0005084_abnormal_gallbladder_morpholo0.64939287
124MP0002060_abnormal_skin_morphology0.64832677
125MP0002272_abnormal_nervous_system0.64061317
126MP0008872_abnormal_physiological_respon0.63604900
127MP0002734_abnormal_mechanical_nocicepti0.62013924
128MP0004215_abnormal_myocardial_fiber0.61967314
129MP0008775_abnormal_heart_ventricle0.61949982
130MP0004742_abnormal_vestibular_system0.61676643
131MP0003698_abnormal_male_reproductive0.61109911
132MP0000343_altered_response_to0.59938662
133MP0010771_integument_phenotype0.58494166
134MP0001216_abnormal_epidermal_layer0.57150750
135MP0002876_abnormal_thyroid_physiology0.56410486
136MP0002896_abnormal_bone_mineralization0.53455157
137MP0002132_abnormal_respiratory_system0.51785102
138MP0004947_skin_inflammation0.51411227
139MP0004883_abnormal_blood_vessel0.51114948
140MP0002089_abnormal_postnatal_growth/wei0.50035821
141MP0000613_abnormal_salivary_gland0.48946436
142MP0003953_abnormal_hormone_level0.47809329
143MP0005666_abnormal_adipose_tissue0.47641480
144MP0005310_abnormal_salivary_gland0.46515426
145MP0002009_preneoplasia0.46143320
146MP0001968_abnormal_touch/_nociception0.45187350
147MP0001963_abnormal_hearing_physiology0.44903647
148MP0003941_abnormal_skin_development0.42654490
149* MP0001845_abnormal_inflammatory_respons0.42542379
150MP0000230_abnormal_systemic_arterial0.40696573
151MP0001756_abnormal_urination0.39612123
152MP0005334_abnormal_fat_pad0.35532749

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.60690135
2Abnormal respiratory epithelium morphology (HP:0012253)8.10907673
3Abnormal respiratory motile cilium morphology (HP:0005938)8.10907673
4Dynein arm defect of respiratory motile cilia (HP:0012255)8.00795047
5Absent/shortened dynein arms (HP:0200106)8.00795047
6Abnormal respiratory motile cilium physiology (HP:0012261)7.72313987
7Abnormal ciliary motility (HP:0012262)7.65728181
8Rhinitis (HP:0012384)7.14967197
9Abnormal tarsal ossification (HP:0008369)6.68970650
10Chronic bronchitis (HP:0004469)6.15842485
11Metabolic alkalosis (HP:0200114)6.14237221
12Abnormality of the 1st metacarpal (HP:0010009)5.72150832
13Bronchiectasis (HP:0002110)5.57896028
14Pustule (HP:0200039)5.43645121
15Decreased circulating renin level (HP:0003351)5.22253694
16Right ventricular cardiomyopathy (HP:0011663)5.05359813
17Abnormal foot bone ossification (HP:0010675)4.84076155
18Nasal polyposis (HP:0100582)4.76970667
19Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.74924971
20Short 1st metacarpal (HP:0010034)4.74924971
21Ileus (HP:0002595)4.54195459
22Abnormality of carpal bone ossification (HP:0006257)4.23207274
23Flat acetabular roof (HP:0003180)4.11797711
24Abnormality of the nasal mucosa (HP:0000433)4.10354574
25Short phalanx of the thumb (HP:0009660)3.99448107
26Abnormality of renin-angiotensin system (HP:0000847)3.92796616
27True hermaphroditism (HP:0010459)3.85592730
28Pancreatic fibrosis (HP:0100732)3.84968704
29Hyperactive renin-angiotensin system (HP:0000841)3.79073663
30Pancreatic cysts (HP:0001737)3.70443459
31Septate vagina (HP:0001153)3.61626388
32Molar tooth sign on MRI (HP:0002419)3.61013830
33Abnormality of midbrain morphology (HP:0002418)3.61013830
34Abdominal distention (HP:0003270)3.55787020
35Ureteral stenosis (HP:0000071)3.50966761
36Abnormality of the 2nd finger (HP:0004100)3.48269950
37Chronic diarrhea (HP:0002028)3.42470892
38Nephronophthisis (HP:0000090)3.37759010
39Bronchitis (HP:0012387)3.37622469
40Abnormality of small intestinal villus morphology (HP:0011472)3.33102744
41Villous atrophy (HP:0011473)3.33102744
42Abnormal hand bone ossification (HP:0010660)3.25311436
43Hyperventilation (HP:0002883)3.22487316
44Abnormal ossification of hand bones (HP:0005921)3.19780540
45Ureteral obstruction (HP:0006000)3.15072337
46Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.14672936
47Cystic liver disease (HP:0006706)3.12285614
48Chronic sinusitis (HP:0011109)3.11746577
49Recurrent sinusitis (HP:0011108)3.08658112
50Hyperaldosteronism (HP:0000859)3.00458642
51Abnormality of the renal medulla (HP:0100957)2.94490947
52Colitis (HP:0002583)2.93808586
53Occipital encephalocele (HP:0002085)2.93079493
54Infertility (HP:0000789)2.92942288
55Conjugated hyperbilirubinemia (HP:0002908)2.89034490
56Chronic hepatic failure (HP:0100626)2.88369913
57Dicarboxylic aciduria (HP:0003215)2.87865891
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.87865891
59Abnormality of the distal phalanx of the thumb (HP:0009617)2.87400102
60Vertebral clefting (HP:0008428)2.81226867
61Alkalosis (HP:0001948)2.79577630
62Tubular atrophy (HP:0000092)2.76762193
63Spontaneous abortion (HP:0005268)2.74968687
64Acute necrotizing encephalopathy (HP:0006965)2.73452400
65Petechiae (HP:0000967)2.70778482
66Flattened epiphyses (HP:0003071)2.67509844
67Hyperparathyroidism (HP:0000843)2.67020556
68Short hallux (HP:0010109)2.63709426
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.61573252
70Abnormality of the vitamin B12 metabolism (HP:0004341)2.60518205
71Inflammation of the large intestine (HP:0002037)2.59047331
72Micronodular cirrhosis (HP:0001413)2.56285316
73Chronic otitis media (HP:0000389)2.48710867
74Male infertility (HP:0003251)2.47253078
75Abnormality of the renal cortex (HP:0011035)2.45796878
76Congenital sensorineural hearing impairment (HP:0008527)2.43474142
77Alopecia of scalp (HP:0002293)2.43262028
78Renal salt wasting (HP:0000127)2.43077769
79Abnormal mitochondria in muscle tissue (HP:0008316)2.42102670
80Abnormality of vitamin B metabolism (HP:0004340)2.41729936
81Abnormality of chloride homeostasis (HP:0011422)2.41361972
82Hypokalemia (HP:0002900)2.41210732
83Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.41011824
84Acute encephalopathy (HP:0006846)2.37564472
85Medial flaring of the eyebrow (HP:0010747)2.36886058
86Hyperkalemia (HP:0002153)2.36040498
87Proximal placement of thumb (HP:0009623)2.35894025
88Recurrent otitis media (HP:0000403)2.35170755
89Short middle phalanx of finger (HP:0005819)2.33241213
90Aplasia/Hypoplasia of the hallux (HP:0008362)2.30578553
91Gastrointestinal inflammation (HP:0004386)2.30494002
92Symptomatic seizures (HP:0011145)2.28022723
93Palpitations (HP:0001962)2.27711341
94Thin bony cortex (HP:0002753)2.27053374
95Symphalangism affecting the phalanges of the hand (HP:0009773)2.25735904
96Vascular calcification (HP:0004934)2.25437069
97Postaxial foot polydactyly (HP:0001830)2.24606310
98Abnormality of glutamine family amino acid metabolism (HP:0010902)2.24436824
99Viral hepatitis (HP:0006562)2.24316681
100Woolly hair (HP:0002224)2.24268786
101Progressive macrocephaly (HP:0004481)2.24184720
102Fragile nails (HP:0001808)2.24113918
103Cheilitis (HP:0100825)2.23262043
104Congenital hepatic fibrosis (HP:0002612)2.22737347
105Tubulointerstitial nephritis (HP:0001970)2.21839273
106Atrophic scars (HP:0001075)2.21247810
107Deviation of the thumb (HP:0009603)2.20833165
108Aplasia/Hypoplasia of the spleen (HP:0010451)2.19687609
109Mildly elevated creatine phosphokinase (HP:0008180)2.19091985
110Malnutrition (HP:0004395)2.18986002
111Furrowed tongue (HP:0000221)2.18874518
112Syncope (HP:0001279)2.16501747
113Ventricular fibrillation (HP:0001663)2.15599549
114Neonatal short-limb short stature (HP:0008921)2.10754729
115Plantar hyperkeratosis (HP:0007556)2.10331531
116Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.09391667
117Fragile skin (HP:0001030)2.09284243
118Abnormality of the gastric mucosa (HP:0004295)2.08446521
119Cardiovascular calcification (HP:0011915)2.07603252
120Cupped ribs (HP:0000887)2.06418796
121Male pseudohermaphroditism (HP:0000037)2.04523361
122Decreased central vision (HP:0007663)2.04197420
123Abnormality of vitamin metabolism (HP:0100508)2.04073087
124Abnormal drinking behavior (HP:0030082)2.02567376
125Polydipsia (HP:0001959)2.02567376
126Methylmalonic aciduria (HP:0012120)2.00212194
127Progressive hearing impairment (HP:0001730)1.99896945
128Abnormal cartilage morphology (HP:0002763)1.97959308
129Asplenia (HP:0001746)1.97452140
130Anencephaly (HP:0002323)1.97233164
131Hydroxyprolinuria (HP:0003080)1.96952526
132Abnormality of proline metabolism (HP:0010907)1.96952526
133Milia (HP:0001056)1.95715682
134Hyponatremia (HP:0002902)1.95406426
135Abnormal delayed hypersensitivity skin test (HP:0002963)1.94280374
136Sclerocornea (HP:0000647)1.93144288
137Goiter (HP:0000853)1.91105537
138Widely patent fontanelles and sutures (HP:0004492)1.86964201
139Hoarse voice (HP:0001609)1.86917841
140Congenital primary aphakia (HP:0007707)1.85302415
141Intrahepatic cholestasis (HP:0001406)1.85037366
142Abnormality of potassium homeostasis (HP:0011042)1.84105433
143Congenital stationary night blindness (HP:0007642)1.83692122
144Gait imbalance (HP:0002141)1.83072618
145Spinal cord compression (HP:0002176)1.82765797
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.81839190
147Abnormal rod and cone electroretinograms (HP:0008323)1.81065084
148Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80780811
149Gastrointestinal dysmotility (HP:0002579)1.76450907
150Mitochondrial inheritance (HP:0001427)1.76175348
151Bundle branch block (HP:0011710)1.72709744
152Abnormality of renal excretion (HP:0011036)1.72678440
153Acanthocytosis (HP:0001927)1.70909413
154Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.70688085
155Aplasia/hypoplasia of the femur (HP:0005613)1.69807739
156Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.69311373
157Hypokalemic alkalosis (HP:0001949)1.66845676
158Nephrogenic diabetes insipidus (HP:0009806)1.64920766
159Attenuation of retinal blood vessels (HP:0007843)1.62118986
160Nephropathy (HP:0000112)1.60533303
161Abolished electroretinogram (ERG) (HP:0000550)1.58539199
162Congenital, generalized hypertrichosis (HP:0004540)1.58036091
163Postaxial hand polydactyly (HP:0001162)1.54664694
164Large for gestational age (HP:0001520)1.54128353
165Abnormality of macular pigmentation (HP:0008002)1.51592928
166Atelectasis (HP:0100750)1.50435331
167Polyuria (HP:0000103)1.49707721
168Hypoalbuminemia (HP:0003073)1.49585079
169Abnormal albumin level (HP:0012116)1.49585079
170Stage 5 chronic kidney disease (HP:0003774)1.48585995
171Retinitis pigmentosa (HP:0000510)1.48583419
172Methylmalonic acidemia (HP:0002912)1.47735111
173Recurrent bronchitis (HP:0002837)1.46346208
174Stomach cancer (HP:0012126)1.46223574
175Abnormality of monocarboxylic acid metabolism (HP:0010996)1.41291443
176Oculomotor apraxia (HP:0000657)1.39863960
177Abnormal biliary tract physiology (HP:0012439)1.38443308
178Bile duct proliferation (HP:0001408)1.38443308
179Abnormality of sodium homeostasis (HP:0010931)1.37118956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.69577079
2MAP3K75.42238382
3MAPK155.21738829
4FRK4.51705453
5MST43.75345686
6ACVR1B3.44264698
7PIK3CA3.24488043
8MAP2K23.02364293
9TLK12.91893227
10NME12.88039931
11ARAF2.79483100
12ADRBK22.67316218
13LMTK22.62892623
14CAMKK22.42538291
15EPHB22.37252994
16CAMK1D2.26482472
17NUAK12.07314158
18ERBB42.05300192
19PTK62.01228786
20STK111.95397467
21BMPR1B1.93635937
22PIM21.86994393
23GRK11.82631335
24PRKG21.80162577
25MAP4K21.77481097
26DDR21.77329318
27MYLK1.71530164
28MET1.69382740
29DMPK1.65886830
30PRKAA21.59576913
31TAOK31.55714415
32CAMK1G1.47117305
33TESK11.45834954
34RAF11.40360169
35TXK1.36663262
36MAPKAPK31.36403559
37TEC1.35974071
38MAP3K91.35148716
39INSRR1.32083027
40PINK11.30788718
41STK241.29351975
42WNK31.27117469
43ZAK1.25036575
44TAOK11.20009430
45CAMKK11.19178931
46MATK1.16869927
47STK161.15477061
48EPHA31.13263718
49RIPK41.11121116
50MAP2K11.10302100
51MAP3K121.10059811
52BRAF1.08333303
53PTK2B1.06007535
54MAPK131.04733871
55EPHA21.03861465
56NLK1.00049185
57GRK60.99148305
58MAP3K40.91834572
59CASK0.91588660
60IRAK10.91515092
61PRKCI0.89417010
62ADRBK10.87195586
63TNIK0.84051662
64PASK0.81949557
65PRKAA10.81432312
66LIMK10.77553652
67ERBB20.77344541
68CAMK2D0.76608684
69SCYL20.73805102
70TRPM70.71638143
71PAK10.68813454
72KSR20.66903337
73MAP3K20.66799922
74CAMK2B0.63067121
75ICK0.62660370
76DYRK1B0.60469183
77DAPK20.58913218
78STK38L0.58431224
79DAPK30.57520357
80RIPK10.56887296
81PDPK10.56534846
82PHKG20.56451123
83PHKG10.56451123
84ITK0.54619172
85CAMK2G0.52706093
86CSK0.51654142
87MUSK0.51281509
88CDC42BPA0.50425339
89PAK30.50346686
90PRKCQ0.50147122
91WNK40.49708256
92BRSK20.46637649
93IKBKB0.45786531
94STK390.45502697
95MAP3K130.44557744
96PAK40.44465843
97ROCK10.43859650
98FER0.43714433
99EPHB10.43335694
100FGFR20.42298342
101FYN0.42082056
102PDK10.41322692
103PRKG10.41259531
104OXSR10.40322889
105PRKACA0.40228598
106CHUK0.40188326
107PRKACG0.38734892
108ROCK20.38589683
109FGR0.38393646
110TYRO30.38132705
111EPHA40.36528793
112KIT0.35484338
113STK100.35246204
114ERBB30.34634245
115PRKCA0.33775291
116TRIM280.32708818
117PRKCZ0.32354646
118IGF1R0.31684937
119MAPKAPK50.30793969
120JAK20.30614229
121ERN10.30609032
122NTRK30.30178590
123ILK0.29914705
124STK30.29081622
125SRC0.28932628
126PIK3CG0.28710544
127MKNK20.28059697
128TBK10.27869170
129MAP3K100.27593687
130RPS6KA20.26782148
131DYRK20.25986874
132PRKCD0.24892006
133PRKCG0.23754737
134CDK150.23151313
135PRKD20.22723829
136ABL10.22123674
137CDK140.22098625
138MAP2K70.21569947
139SGK10.21336803
140MAP3K10.21048433
141MAP2K60.20991743
142TYK20.20797992
143MAP3K80.20713974
144MARK10.20598716
145CDK180.19168856
146IKBKE0.18593352
147MAPK110.18221459
148CDK50.16866002
149CSNK1A10.16276246
150CDK11A0.16182860
151TTN0.15867802
152BCR0.15407296
153CAMK10.12390985
154CAMK2A0.12195491
155PRKCE0.11076409
156PRKACB0.10700731

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009206.00232993
2Fat digestion and absorption_Homo sapiens_hsa049753.70342294
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.91294795
4Linoleic acid metabolism_Homo sapiens_hsa005912.80347041
5Mineral absorption_Homo sapiens_hsa049782.76815124
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74947397
7Oxidative phosphorylation_Homo sapiens_hsa001902.61366207
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.59073593
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20932030
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15821671
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.14819279
12Parkinsons disease_Homo sapiens_hsa050122.12034564
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.91836119
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.91137415
15Alzheimers disease_Homo sapiens_hsa050101.87068017
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.82174077
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80935965
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78562173
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69601564
20Pancreatic secretion_Homo sapiens_hsa049721.65973523
21Bile secretion_Homo sapiens_hsa049761.61438714
22Ether lipid metabolism_Homo sapiens_hsa005651.59957136
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51416677
24Butanoate metabolism_Homo sapiens_hsa006501.50527620
25Galactose metabolism_Homo sapiens_hsa000521.50102894
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45488931
27Starch and sucrose metabolism_Homo sapiens_hsa005001.44760954
28Fructose and mannose metabolism_Homo sapiens_hsa000511.43008411
29Chemical carcinogenesis_Homo sapiens_hsa052041.42915314
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.42719634
31Gastric acid secretion_Homo sapiens_hsa049711.40127062
32Peroxisome_Homo sapiens_hsa041461.38854700
33Histidine metabolism_Homo sapiens_hsa003401.37189777
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35256240
35beta-Alanine metabolism_Homo sapiens_hsa004101.29111827
36Huntingtons disease_Homo sapiens_hsa050161.26211214
37Phototransduction_Homo sapiens_hsa047441.25010178
38Arachidonic acid metabolism_Homo sapiens_hsa005901.22889019
39Cardiac muscle contraction_Homo sapiens_hsa042601.19967338
40Vitamin digestion and absorption_Homo sapiens_hsa049771.18149677
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15470936
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11398627
43Type I diabetes mellitus_Homo sapiens_hsa049401.08081273
44Asthma_Homo sapiens_hsa053101.08067756
45African trypanosomiasis_Homo sapiens_hsa051431.03319803
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.02794048
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00977683
48Circadian rhythm_Homo sapiens_hsa047101.00100376
49Tight junction_Homo sapiens_hsa045300.96997919
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95741072
51Sphingolipid metabolism_Homo sapiens_hsa006000.95731944
52Allograft rejection_Homo sapiens_hsa053300.94482395
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93895661
54Retinol metabolism_Homo sapiens_hsa008300.92626023
55Glutathione metabolism_Homo sapiens_hsa004800.91852386
56Taste transduction_Homo sapiens_hsa047420.87377474
57Tryptophan metabolism_Homo sapiens_hsa003800.86760617
58Autoimmune thyroid disease_Homo sapiens_hsa053200.85009418
59Salivary secretion_Homo sapiens_hsa049700.83977135
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83191151
61Renin-angiotensin system_Homo sapiens_hsa046140.82552018
62Arginine biosynthesis_Homo sapiens_hsa002200.81764705
63Carbon metabolism_Homo sapiens_hsa012000.80289680
64Pyruvate metabolism_Homo sapiens_hsa006200.78006209
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77327198
66Selenocompound metabolism_Homo sapiens_hsa004500.76430563
67Fatty acid degradation_Homo sapiens_hsa000710.75875396
68Graft-versus-host disease_Homo sapiens_hsa053320.74932268
69Caffeine metabolism_Homo sapiens_hsa002320.71225805
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.69063692
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67841410
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67726573
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.67589847
74ABC transporters_Homo sapiens_hsa020100.62762198
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.62657921
76PPAR signaling pathway_Homo sapiens_hsa033200.62141188
77Thyroid hormone synthesis_Homo sapiens_hsa049180.61163337
78Protein digestion and absorption_Homo sapiens_hsa049740.60262570
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.59436877
80Sulfur relay system_Homo sapiens_hsa041220.58534945
81Ovarian steroidogenesis_Homo sapiens_hsa049130.56554818
82Salmonella infection_Homo sapiens_hsa051320.55591102
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.55577619
84Glycerolipid metabolism_Homo sapiens_hsa005610.54724114
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52355963
86Nicotine addiction_Homo sapiens_hsa050330.50027247
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48991195
88Phenylalanine metabolism_Homo sapiens_hsa003600.47139051
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.46639482
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44060008
91Fatty acid metabolism_Homo sapiens_hsa012120.43184476
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.42827892
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42769436
94Propanoate metabolism_Homo sapiens_hsa006400.41163238
95Nitrogen metabolism_Homo sapiens_hsa009100.40862916
96Glucagon signaling pathway_Homo sapiens_hsa049220.39941794
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39681285
98Metabolic pathways_Homo sapiens_hsa011000.38619272
99Olfactory transduction_Homo sapiens_hsa047400.38129782
100Insulin secretion_Homo sapiens_hsa049110.36200745
101Tyrosine metabolism_Homo sapiens_hsa003500.35865020
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35396743
103Collecting duct acid secretion_Homo sapiens_hsa049660.35291286
104Adherens junction_Homo sapiens_hsa045200.33876502
105Regulation of autophagy_Homo sapiens_hsa041400.33448753
106Serotonergic synapse_Homo sapiens_hsa047260.33406448
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31920478
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31550631
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30353102
110Renin secretion_Homo sapiens_hsa049240.30016887
111GnRH signaling pathway_Homo sapiens_hsa049120.29288371
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29049246
113Cocaine addiction_Homo sapiens_hsa050300.28334463
114Pentose phosphate pathway_Homo sapiens_hsa000300.27755937
115Inositol phosphate metabolism_Homo sapiens_hsa005620.26012525
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23750227
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22846272
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22507645
119Vibrio cholerae infection_Homo sapiens_hsa051100.20090671
120Purine metabolism_Homo sapiens_hsa002300.19647762
121Bladder cancer_Homo sapiens_hsa052190.19581754
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19205537
123Hepatitis C_Homo sapiens_hsa051600.18899700
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.18407950
125Fatty acid biosynthesis_Homo sapiens_hsa000610.18091418
126Arginine and proline metabolism_Homo sapiens_hsa003300.17986174
127Protein export_Homo sapiens_hsa030600.17637659
128Insulin resistance_Homo sapiens_hsa049310.16833677
129Gap junction_Homo sapiens_hsa045400.16366192
130Oxytocin signaling pathway_Homo sapiens_hsa049210.16191266
131Antigen processing and presentation_Homo sapiens_hsa046120.16085035

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