ERP27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a noncatalytic member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. The canonical protein has an N-terminal signal sequence, two thioredoxin (TRX)-like domains and a C-terminal ER-retention sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which lack domains present in the canonical protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cobalamin metabolic process (GO:0009235)8.54572168
2sterol catabolic process (GO:0016127)7.96000304
3cholesterol catabolic process (GO:0006707)7.96000304
4transcytosis (GO:0045056)7.93865362
5intestinal absorption (GO:0050892)7.24308950
6regulation of phospholipase A2 activity (GO:0032429)7.19290084
7peptidyl-proline hydroxylation (GO:0019511)7.13774048
8cysteine metabolic process (GO:0006534)6.97599967
9glycolipid catabolic process (GO:0019377)6.95789957
10negative regulation of digestive system process (GO:0060457)6.83345487
11membrane lipid catabolic process (GO:0046466)6.31357339
12valine metabolic process (GO:0006573)6.11321989
13branched-chain amino acid catabolic process (GO:0009083)6.05962416
14proline biosynthetic process (GO:0006561)6.05206789
15ceramide catabolic process (GO:0046514)5.67579535
16protein hydroxylation (GO:0018126)5.51537806
17branched-chain amino acid metabolic process (GO:0009081)5.37098831
18cellular modified amino acid catabolic process (GO:0042219)5.36207206
19serine family amino acid biosynthetic process (GO:0009070)5.10744451
20zinc ion transport (GO:0006829)4.99786386
21mitochondrial calcium ion transport (GO:0006851)4.96094099
22leukotriene biosynthetic process (GO:0019370)4.85051544
23positive regulation of heat generation (GO:0031652)4.83247728
24COPI coating of Golgi vesicle (GO:0048205)4.78169513
25Golgi transport vesicle coating (GO:0048200)4.78169513
26regulation of fever generation (GO:0031620)4.69411287
27homocysteine metabolic process (GO:0050667)4.65750901
28interferon-gamma secretion (GO:0072643)4.59741485
29phosphatidylserine acyl-chain remodeling (GO:0036150)4.59455658
30protein maturation by protein folding (GO:0022417)4.58490701
31phosphatidylinositol acyl-chain remodeling (GO:0036149)4.53399266
32activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.44315301
33aspartate family amino acid catabolic process (GO:0009068)4.44077532
34signal peptide processing (GO:0006465)4.42087385
35creatine metabolic process (GO:0006600)4.30159778
36neutrophil mediated immunity (GO:0002446)4.28204192
37neutrophil activation involved in immune response (GO:0002283)4.26872338
38positive regulation of nuclease activity (GO:0032075)4.24696061
39L-serine metabolic process (GO:0006563)4.20451102
40glutamine metabolic process (GO:0006541)4.17646439
41proline metabolic process (GO:0006560)4.15249245
42maintenance of protein localization in organelle (GO:0072595)4.15145758
43response to interferon-beta (GO:0035456)4.10900348
44endoplasmic reticulum unfolded protein response (GO:0030968)4.10055542
45transepithelial transport (GO:0070633)4.07853718
46coenzyme catabolic process (GO:0009109)4.02365475
474-hydroxyproline metabolic process (GO:0019471)4.00410179
48steroid catabolic process (GO:0006706)3.99730758
49cellular response to unfolded protein (GO:0034620)3.99070739
50GDP-mannose metabolic process (GO:0019673)3.98040629
51serine family amino acid metabolic process (GO:0009069)3.97833433
52L-phenylalanine catabolic process (GO:0006559)3.96868738
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.96868738
54regulation of nuclease activity (GO:0032069)3.86997139
55* response to endoplasmic reticulum stress (GO:0034976)3.86803340
56mitochondrion distribution (GO:0048311)3.83332004
57negative T cell selection (GO:0043383)3.82983604
58L-phenylalanine metabolic process (GO:0006558)3.81625598
59erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.81625598
60cellular response to topologically incorrect protein (GO:0035967)3.79980733
61phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.78442915
62ER-nucleus signaling pathway (GO:0006984)3.76494857
63negative regulation of epidermal cell differentiation (GO:0045605)3.73672334
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72131180
65regulation of heat generation (GO:0031650)3.68122071
66intestinal epithelial cell development (GO:0060576)3.66953481
67antibacterial humoral response (GO:0019731)3.61225345
68sphingolipid catabolic process (GO:0030149)3.60104948
69antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.59596141
70positive regulation of gamma-delta T cell activation (GO:0046645)3.57410144
71negative thymic T cell selection (GO:0045060)3.55627285
72ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.52065942
73antigen processing and presentation of endogenous antigen (GO:0019883)3.47859894
74sulfur amino acid biosynthetic process (GO:0000097)3.45749174
75phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.39567647
76regulation of B cell receptor signaling pathway (GO:0050855)3.39218334
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36933100
78glycine metabolic process (GO:0006544)3.36843795
79regulation of gamma-delta T cell differentiation (GO:0045586)3.33719806
80antimicrobial humoral response (GO:0019730)3.33290080
81macrophage activation involved in immune response (GO:0002281)3.32474999
82neutrophil activation (GO:0042119)3.30614825
83retinoic acid receptor signaling pathway (GO:0048384)3.29152373
84COPII vesicle coating (GO:0048208)3.28448235
85defense response to Gram-positive bacterium (GO:0050830)3.26676505
86hepatocyte apoptotic process (GO:0097284)3.26165499
87alpha-amino acid biosynthetic process (GO:1901607)3.24930968
88myeloid leukocyte mediated immunity (GO:0002444)3.24523346
89phosphatidylcholine acyl-chain remodeling (GO:0036151)3.23504898
90ER overload response (GO:0006983)3.23109295
91cell redox homeostasis (GO:0045454)3.22154021
92response to unfolded protein (GO:0006986)3.20967542
93protein N-linked glycosylation via asparagine (GO:0018279)3.20278077
94regulation of alpha-beta T cell proliferation (GO:0046640)3.20029752
95arachidonic acid secretion (GO:0050482)3.19284707
96icosanoid secretion (GO:0032309)3.19284707
97positive T cell selection (GO:0043368)3.19152396
98regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.19081996
99activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.17214571
100negative regulation of cell killing (GO:0031342)3.16748603
101negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.16748603
102peptidyl-asparagine modification (GO:0018196)3.16642506
103phosphatidylserine metabolic process (GO:0006658)3.15857794
104negative regulation of complement activation (GO:0045916)3.14191216
105biotin metabolic process (GO:0006768)3.13932098
106regulation of gamma-delta T cell activation (GO:0046643)3.13245218
107positive regulation of alpha-beta T cell proliferation (GO:0046641)3.11864133
108regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)3.10671117
109acute-phase response (GO:0006953)3.09908991
110tetrapyrrole metabolic process (GO:0033013)3.09819877
111response to topologically incorrect protein (GO:0035966)3.09441754
112negative regulation of epidermis development (GO:0045683)3.08928031
113keratinocyte development (GO:0003334)3.07578914
114negative regulation of humoral immune response (GO:0002921)3.07568774
115I-kappaB phosphorylation (GO:0007252)3.05936203
116positive regulation of granulocyte differentiation (GO:0030854)3.05685854
117regulation of keratinocyte differentiation (GO:0045616)3.03953469
118regulation of interleukin-8 secretion (GO:2000482)3.03544798
119endocrine pancreas development (GO:0031018)3.02485983
120monoamine transport (GO:0015844)3.01865583
121retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.01329710
122myeloid cell activation involved in immune response (GO:0002275)3.01297214
123glycine transport (GO:0015816)2.97029442
124negative regulation of cell fate commitment (GO:0010454)2.97019140
125polarized epithelial cell differentiation (GO:0030859)2.96820171
126cholesterol transport (GO:0030301)2.96307352
127sterol transport (GO:0015918)2.96307352
128purinergic nucleotide receptor signaling pathway (GO:0035590)2.96285770
129regulation of oxidative stress-induced cell death (GO:1903201)2.94295814
130sulfur amino acid catabolic process (GO:0000098)2.93821081
131response to protozoan (GO:0001562)2.93648980
132aspartate family amino acid metabolic process (GO:0009066)2.93211443
133protein N-linked glycosylation (GO:0006487)2.93106691
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93060596
135activated T cell proliferation (GO:0050798)2.90622605
136peptide catabolic process (GO:0043171)2.90503253
137positive regulation of interleukin-2 production (GO:0032743)2.87752650
138negative regulation of protein activation cascade (GO:2000258)2.87749355
139positive regulation of toll-like receptor signaling pathway (GO:0034123)2.86099034
140mast cell activation (GO:0045576)2.85393143
141cellular response to interleukin-15 (GO:0071350)2.85338431
142regulation of regulatory T cell differentiation (GO:0045589)2.81914973
143leukocyte degranulation (GO:0043299)2.81301261
144leukocyte aggregation (GO:0070486)2.79409154
145detection of molecule of bacterial origin (GO:0032490)2.78265730
146granulocyte activation (GO:0036230)2.78115312
147innate immune response in mucosa (GO:0002227)2.78091886
148regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.77212008
149positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.77212008
150opsonization (GO:0008228)2.74813671
151positive regulation of respiratory burst (GO:0060267)2.74396607
152positive thymic T cell selection (GO:0045059)2.71934139
153tolerance induction (GO:0002507)2.69338077
154B cell receptor signaling pathway (GO:0050853)2.69199031
155cellular response to type I interferon (GO:0071357)2.68182223
156type I interferon signaling pathway (GO:0060337)2.68182223
157response to type I interferon (GO:0034340)2.67859364
158neutrophil chemotaxis (GO:0030593)2.67332843
159negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.66143105
160response to nitrosative stress (GO:0051409)2.64047295
161diterpenoid biosynthetic process (GO:0016102)2.64009170
162T cell selection (GO:0045058)2.62862397
163regulation of respiratory burst (GO:0060263)2.62348620
164neutrophil migration (GO:1990266)2.62034433
165regulation of memory T cell differentiation (GO:0043380)2.62030384
166immunoglobulin mediated immune response (GO:0016064)2.60625348
167acute inflammatory response (GO:0002526)2.57173850
168histone mRNA catabolic process (GO:0071044)2.56590010
169alditol phosphate metabolic process (GO:0052646)2.56493737
170response to interleukin-15 (GO:0070672)2.56418747
171G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.54749979
172negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.54084648
173negative regulation of T-helper cell differentiation (GO:0045623)2.54084648
174regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.52943377
175positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.52943377
176negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.51266200
177regulation of keratinocyte proliferation (GO:0010837)2.50886619
178calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.50750704
179positive regulation of mRNA catabolic process (GO:0061014)2.50684913
180phospholipid scrambling (GO:0017121)2.50385794
181antigen receptor-mediated signaling pathway (GO:0050851)2.50301990
182mucosal immune response (GO:0002385)2.47641405
183intestinal cholesterol absorption (GO:0030299)17.2981487
184exocrine pancreas development (GO:0031017)16.9383008
185digestion (GO:0007586)14.0042659
186protein retention in ER lumen (GO:0006621)12.3341625
187maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.4131588

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.70215608
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.91640676
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.86399810
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.36384307
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.23709958
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.15200512
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.75463591
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.72720492
9ERG_21242973_ChIP-ChIP_JURKAT_Human3.34855000
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.83420357
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.83400406
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.78454035
13ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.70801392
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.63805897
15* RXR_22158963_ChIP-Seq_LIVER_Mouse2.52081432
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.49249555
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.49249555
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.49249555
19MYB_26560356_Chip-Seq_TH2_Human2.30189617
20GATA4_25053715_ChIP-Seq_YYC3_Human2.23731504
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22676373
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.21603723
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.17658998
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15750416
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13653185
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13519241
27LXR_22158963_ChIP-Seq_LIVER_Mouse2.07323287
28EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05115752
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.02214492
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.95761367
31GATA3_26560356_Chip-Seq_TH2_Human1.95103939
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88653743
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86440895
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.85233935
35* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.84480381
36GATA6_25053715_ChIP-Seq_YYC3_Human1.81650707
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80580467
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78704515
39GATA3_27048872_Chip-Seq_THYMUS_Human1.74676904
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74443019
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.72977573
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71961667
43* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70221990
44MYB_26560356_Chip-Seq_TH1_Human1.69388634
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.68137146
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.64796035
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63710484
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.63165276
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60545920
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59357407
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54911061
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51991971
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51151024
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50340812
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49980146
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49603293
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.49451313
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46749971
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46028879
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44719342
61EGR1_19032775_ChIP-ChIP_M12_Human1.44566489
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.42386489
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41667232
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.38664574
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35675924
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.35071377
67RUNX_20019798_ChIP-Seq_JUKART_Human1.33432777
68VDR_24787735_ChIP-Seq_THP-1_Human1.32332429
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.30815225
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28356767
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28151884
72SPI1_23547873_ChIP-Seq_NB4_Human1.27454538
73LXR_22292898_ChIP-Seq_THP-1_Human1.27348877
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24922025
75* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24364350
76P68_20966046_ChIP-Seq_HELA_Human1.23847756
77ESET_19884257_ChIP-Seq_ESCs_Mouse1.23666182
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23300689
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23270764
80SCL_19346495_ChIP-Seq_HPC-7_Human1.19866296
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19571930
82CHD1_26751641_Chip-Seq_LNCaP_Human1.19504584
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17440919
84IRF1_19129219_ChIP-ChIP_H3396_Human1.16633912
85ETS1_21867929_ChIP-Seq_TH2_Mouse1.15545727
86ERA_21632823_ChIP-Seq_H3396_Human1.15057021
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.14869028
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13537816
89ERG_20517297_ChIP-Seq_VCAP_Human1.13181283
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12571635
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12525984
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12037875
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11653830
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10397222
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10195662
96TAF2_19829295_ChIP-Seq_ESCs_Human1.09912717
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07708675
98GATA1_22025678_ChIP-Seq_K562_Human1.07244540
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.06585302
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05119174
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04302638
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03934303
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03764863
104BCOR_27268052_Chip-Seq_Bcells_Human1.03269364
105GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02999800
106AR_20517297_ChIP-Seq_VCAP_Human1.01947935
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01899315
108SMRT_27268052_Chip-Seq_Bcells_Human1.01784495
109RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00475442
110SPI1_23127762_ChIP-Seq_K562_Human1.00349144
111GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99399374
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99155607
113CREB1_26743006_Chip-Seq_LNCaP_Human0.99019699
114MYC_22102868_ChIP-Seq_BL_Human0.98629338
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98622054
116P53_21459846_ChIP-Seq_SAOS-2_Human0.97861797
117OCT4_20526341_ChIP-Seq_ESCs_Human0.97538284
118FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97428796
119RUNX1_22412390_ChIP-Seq_EML_Mouse0.97336682
120CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96227591
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96178215
122* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95918857
123GATA6_21074721_ChIP-Seq_CACO-2_Human0.94874852
124MYC_18555785_ChIP-Seq_MESCs_Mouse0.94405876
125SA1_27219007_Chip-Seq_Bcells_Human0.94162098
126SOX2_20726797_ChIP-Seq_SW620_Human0.93596201
127SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.92813525
128CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92794408
129HTT_18923047_ChIP-ChIP_STHdh_Human0.91251166
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.91076427
131FOXH1_21741376_ChIP-Seq_ESCs_Human0.90488227
132* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90155988
133FOXA1_25329375_ChIP-Seq_VCAP_Human0.89435431
134FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89435431
135MAF_26560356_Chip-Seq_TH1_Human0.89117374
136ETV1_20927104_ChIP-Seq_GIST48_Human0.89037045
137FOXP1_21924763_ChIP-Seq_HESCs_Human0.88607446
138RBPJ_21746931_ChIP-Seq_IB4_Human0.88450474
139GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88217837
140KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88186812
141CEBPB_22108803_ChIP-Seq_LS180_Human0.88077900
142P300_27268052_Chip-Seq_Bcells_Human0.87694569
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.86753664
144HNFA_21074721_ChIP-Seq_CACO-2_Human0.85939824
145ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85919357
146AHR_22903824_ChIP-Seq_MCF-7_Human0.85913433
147* TP63_22573176_ChIP-Seq_HFKS_Human0.84973030
148UTX_26944678_Chip-Seq_JUKART_Human0.84897640
149CDX2_20551321_ChIP-Seq_CACO-2_Human0.84875667
150ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84770098
151FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84738966
152ATF3_27146783_Chip-Seq_COLON_Human0.84050337
153PHF8_20622853_ChIP-Seq_HELA_Human0.83890778
154ETS1_20019798_ChIP-Seq_JURKAT_Human0.83675503
155CDX2_22108803_ChIP-Seq_LS180_Human0.83251817
156GATA3_21878914_ChIP-Seq_MCF-7_Human0.83126112
157CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82158889
158CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81707276
159AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80798015
160SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80706397
161CTCF_20526341_ChIP-Seq_ESCs_Human0.80261530
162STAT1_20625510_ChIP-Seq_HELA_Human0.80095577
163EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.79690648
164IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79223844
165ETS1_22383799_ChIP-Seq_G1ME_Mouse0.77604068
166MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.77488219
167GATA3_26560356_Chip-Seq_TH1_Human0.77342426
168RXRA_24833708_ChIP-Seq_LIVER_Mouse0.75708790
169CTCF_27219007_Chip-Seq_Bcells_Human0.75291895
170CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74780134
171SOX2_22085726_ChIP-Seq_NPCs_Mouse0.74009967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract9.74553159
2MP0001666_abnormal_nutrient_absorption9.38163554
3MP0005365_abnormal_bile_salt6.82461164
4MP0005220_abnormal_exocrine_pancreas6.65516809
5MP0003868_abnormal_feces_composition5.06230173
6MP0005084_abnormal_gallbladder_morpholo4.81154910
7MP0005085_abnormal_gallbladder_physiolo3.72331687
8MP0003195_calcinosis3.65494677
9MP0010386_abnormal_urinary_bladder3.49669657
10MP0003724_increased_susceptibility_to3.42771282
11MP0003300_gastrointestinal_ulcer3.38427526
12MP0002132_abnormal_respiratory_system2.88788541
13MP0001664_abnormal_digestion2.64706236
14MP0003959_abnormal_lean_body2.58590074
15MP0002693_abnormal_pancreas_physiology2.55808106
16MP0001835_abnormal_antigen_presentation2.36415233
17MP0009785_altered_susceptibility_to2.16415420
18MP0005671_abnormal_response_to2.16080698
19MP0001800_abnormal_humoral_immune2.01738195
20MP0002148_abnormal_hypersensitivity_rea2.00943253
21MP0005451_abnormal_body_composition1.98457937
22MP0003436_decreased_susceptibility_to1.90732397
23MP0005000_abnormal_immune_tolerance1.85941200
24MP0005387_immune_system_phenotype1.81985042
25MP0001790_abnormal_immune_system1.81985042
26MP0005025_abnormal_response_to1.81227599
27MP0002723_abnormal_immune_serum1.80530101
28MP0002166_altered_tumor_susceptibility1.80430676
29MP0002139_abnormal_hepatobiliary_system1.75916226
30MP0002420_abnormal_adaptive_immunity1.67776783
31MP0002419_abnormal_innate_immunity1.67010569
32MP0002452_abnormal_antigen_presenting1.66061183
33MP0001819_abnormal_immune_cell1.65514952
34MP0003638_abnormal_response/metabolism_1.64963422
35MP0005448_abnormal_energy_balance1.61450361
36MP0002277_abnormal_respiratory_mucosa1.60340574
37MP0004043_abnormal_pH_regulation1.59541866
38MP0002163_abnormal_gland_morphology1.58063921
39MP0001944_abnormal_pancreas_morphology1.57100705
40MP0004233_abnormal_muscle_weight1.54301149
41MP0003705_abnormal_hypodermis_morpholog1.52377850
42MP0000685_abnormal_immune_system1.44686559
43MP0002118_abnormal_lipid_homeostasis1.39183197
44MP0005332_abnormal_amino_acid1.37538674
45MP0004264_abnormal_extraembryonic_tissu1.36406142
46MP0000716_abnormal_immune_system1.36182266
47MP0002398_abnormal_bone_marrow1.35922666
48MP0003943_abnormal_hepatobiliary_system1.33171597
49MP0003866_abnormal_defecation1.31729516
50MP0000689_abnormal_spleen_morphology1.29736020
51MP0010234_abnormal_vibrissa_follicle1.29521871
52MP0001873_stomach_inflammation1.27954095
53MP0003878_abnormal_ear_physiology1.21187545
54MP0005377_hearing/vestibular/ear_phenot1.21187545
55MP0002006_tumorigenesis1.20421188
56MP0005165_increased_susceptibility_to1.18227276
57MP0008995_early_reproductive_senescence1.14444922
58MP0001533_abnormal_skeleton_physiology1.13103485
59MP0000703_abnormal_thymus_morphology1.12744919
60MP0002722_abnormal_immune_system1.12346176
61MP0005397_hematopoietic_system_phenotyp1.11568879
62MP0001545_abnormal_hematopoietic_system1.11568879
63MP0000490_abnormal_crypts_of1.07800244
64MP0006082_CNS_inflammation1.07221410
65MP0005408_hypopigmentation0.99924439
66MP0000470_abnormal_stomach_morphology0.99578511
67MP0001853_heart_inflammation0.99262516
68MP0002429_abnormal_blood_cell0.98962770
69MP0005379_endocrine/exocrine_gland_phen0.98699170
70MP0001501_abnormal_sleep_pattern0.97965587
71MP0008004_abnormal_stomach_pH0.97303843
72MP0003950_abnormal_plasma_membrane0.96237440
73MP0001851_eye_inflammation0.94881265
74MP0009278_abnormal_bone_marrow0.94452408
75MP0003806_abnormal_nucleotide_metabolis0.93524786
76MP0003786_premature_aging0.89721066
77MP0009384_cardiac_valve_regurgitation0.89107856
78MP0000383_abnormal_hair_follicle0.88483256
79MP0002078_abnormal_glucose_homeostasis0.86738423
80MP0005535_abnormal_body_temperature0.86637514
81MP0003186_abnormal_redox_activity0.84386669
82MP0000465_gastrointestinal_hemorrhage0.84012044
83MP0000516_abnormal_urinary_system0.83397066
84MP0005367_renal/urinary_system_phenotyp0.83397066
85MP0001756_abnormal_urination0.82868361
86MP0004947_skin_inflammation0.82722571
87MP0009643_abnormal_urine_homeostasis0.82476373
88MP0005058_abnormal_lysosome_morphology0.81907000
89MP0004381_abnormal_hair_follicle0.81850631
90MP0003045_fibrosis0.80746232
91MP0005464_abnormal_platelet_physiology0.80207718
92MP0008438_abnormal_cutaneous_collagen0.80165754
93MP0005310_abnormal_salivary_gland0.79266048
94MP0001764_abnormal_homeostasis0.79257523
95MP0001663_abnormal_digestive_system0.78974709
96MP0002168_other_aberrant_phenotype0.78588725
97MP0004883_abnormal_blood_vessel0.78403035
98MP0005075_abnormal_melanosome_morpholog0.77884607
99MP0002396_abnormal_hematopoietic_system0.77288710
100MP0005360_urolithiasis0.75739144
101MP0005166_decreased_susceptibility_to0.75681322
102MP0008789_abnormal_olfactory_epithelium0.74651556
103MP0006036_abnormal_mitochondrial_physio0.73598044
104MP0009765_abnormal_xenobiotic_induced0.73485992
105MP0005164_abnormal_response_to0.72688659
106MP0005647_abnormal_sex_gland0.71475061
107MP0001765_abnormal_ion_homeostasis0.71405007
108MP0002136_abnormal_kidney_physiology0.70586034
109MP0005670_abnormal_white_adipose0.69902997
110MP0003252_abnormal_bile_duct0.69633101
111MP0004808_abnormal_hematopoietic_stem0.68760878
112MP0003953_abnormal_hormone_level0.66379854
113MP0002089_abnormal_postnatal_growth/wei0.66193478
114MP0003763_abnormal_thymus_physiology0.66051047
115MP0000003_abnormal_adipose_tissue0.63536780
116MP0010329_abnormal_lipoprotein_level0.62925477
117MP0001845_abnormal_inflammatory_respons0.61585736
118MP0000598_abnormal_liver_morphology0.61581097
119MP0005452_abnormal_adipose_tissue0.61571244
120MP0006054_spinal_hemorrhage0.58841947
121MP0000613_abnormal_salivary_gland0.58174009
122MP0009333_abnormal_splenocyte_physiolog0.56314991
123MP0005499_abnormal_olfactory_system0.54267219
124MP0005394_taste/olfaction_phenotype0.54267219
125MP0005381_digestive/alimentary_phenotyp0.53845543
126MP0002138_abnormal_hepatobiliary_system0.53634382
127MP0003191_abnormal_cellular_cholesterol0.52139401
128MP0005319_abnormal_enzyme/_coenzyme0.51620653
129MP0000609_abnormal_liver_physiology0.49042967
130MP0001731_abnormal_postnatal_growth0.46147996
131MP0003656_abnormal_erythrocyte_physiolo0.46118612
132MP0000371_diluted_coat_color0.45508955
133MP0000750_abnormal_muscle_regeneration0.45109015
134MP0002098_abnormal_vibrissa_morphology0.45053957
135MP0008872_abnormal_physiological_respon0.41318929
136MP0008961_abnormal_basal_metabolism0.40590719
137MP0000367_abnormal_coat/_hair0.39492409
138MP0003795_abnormal_bone_structure0.39355101
139MP0008469_abnormal_protein_level0.38867506
140MP0002928_abnormal_bile_duct0.37367433
141MP0005334_abnormal_fat_pad0.37156500
142MP0005375_adipose_tissue_phenotype0.36207042
143MP0002796_impaired_skin_barrier0.34954220
144MP0000377_abnormal_hair_follicle0.33657802
145MP0009642_abnormal_blood_homeostasis0.32906984
146MP0002060_abnormal_skin_morphology0.32100056
147MP0002876_abnormal_thyroid_physiology0.30951874
148MP0001348_abnormal_lacrimal_gland0.30722339
149MP0010678_abnormal_skin_adnexa0.29947478
150MP0002405_respiratory_system_inflammati0.28148577
151MP0005386_behavior/neurological_phenoty0.27359327
152MP0004924_abnormal_behavior0.27359327
153MP0009763_increased_sensitivity_to0.27017616
154MP0010155_abnormal_intestine_physiology0.26881946
155MP0003956_abnormal_body_size0.23792364
156MP0005636_abnormal_mineral_homeostasis0.23650587
157MP0002069_abnormal_eating/drinking_beha0.23650222
158MP0000920_abnormal_myelination0.22820541
159MP0002075_abnormal_coat/hair_pigmentati0.21944351
160MP0000647_abnormal_sebaceous_gland0.21409583
161MP0004185_abnormal_adipocyte_glucose0.20106196
162MP0000955_abnormal_spinal_cord0.19267381
163MP0003329_amyloid_beta_deposits0.18334736
164MP0000858_altered_metastatic_potential0.18132165
165MP0001186_pigmentation_phenotype0.17969029
166MP0006035_abnormal_mitochondrial_morpho0.17881511
167MP0009931_abnormal_skin_appearance0.17400457
168MP0008875_abnormal_xenobiotic_pharmacok0.15899534

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)9.15966670
2Fat malabsorption (HP:0002630)7.39927730
3Short chin (HP:0000331)6.92164223
4Decreased subcutaneous fat (HP:0001002)6.25776944
5Abnormality of subcutaneous fat tissue (HP:0001001)5.74796988
6Type I diabetes mellitus (HP:0100651)5.63592845
7Gout (HP:0001997)5.54876247
8Abnormality of the intrinsic pathway (HP:0010989)5.23682694
9Maternal diabetes (HP:0009800)4.92034812
10Exocrine pancreatic insufficiency (HP:0001738)4.82559995
11Abnormality of aromatic amino acid family metabolism (HP:0004338)4.53317452
12Hypoplasia of the pons (HP:0012110)4.37310117
13Premature skin wrinkling (HP:0100678)4.27764746
14Elevated erythrocyte sedimentation rate (HP:0003565)4.26528886
15Hypoproteinemia (HP:0003075)4.23626768
16Abnormality of the pons (HP:0007361)4.18465890
17Pancreatitis (HP:0001733)4.10085300
18Stomatitis (HP:0010280)4.04322794
19Joint stiffness (HP:0001387)3.99859082
20Cortical dysplasia (HP:0002539)3.81378287
21Ketosis (HP:0001946)3.78940601
22Panhypogammaglobulinemia (HP:0003139)3.77159133
23Tubulointerstitial nephritis (HP:0001970)3.65735780
24Abnormality of chloride homeostasis (HP:0011422)3.59747690
25Carpal bone hypoplasia (HP:0001498)3.47989131
26Recurrent fungal infections (HP:0002841)3.32071927
27Hyperglycinemia (HP:0002154)3.24542058
28Long foot (HP:0001833)3.23531808
29Ketoacidosis (HP:0001993)3.22510462
30Eczematoid dermatitis (HP:0000976)3.21511070
31Abnormality of the nasal septum (HP:0000419)3.21254188
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.17067034
33Optic nerve hypoplasia (HP:0000609)3.15478866
34Abnormal protein glycosylation (HP:0012346)3.13027295
35Abnormal glycosylation (HP:0012345)3.13027295
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.13027295
37Abnormal protein N-linked glycosylation (HP:0012347)3.13027295
38Methylmalonic aciduria (HP:0012120)3.07520630
39Myositis (HP:0100614)3.07256887
40Abnormality of the common coagulation pathway (HP:0010990)3.05836977
41Abnormal delayed hypersensitivity skin test (HP:0002963)3.02856422
42Recurrent cutaneous fungal infections (HP:0011370)3.02843711
43Chronic mucocutaneous candidiasis (HP:0002728)3.02843711
44Abnormal pancreas size (HP:0012094)3.00820698
45Reduced antithrombin III activity (HP:0001976)2.95010871
46Hypoglycemic coma (HP:0001325)2.94053280
47Autoimmune hemolytic anemia (HP:0001890)2.91973626
48Pustule (HP:0200039)2.90384449
49Ileus (HP:0002595)2.79719866
50Hyperglycinuria (HP:0003108)2.77219025
51Tubulointerstitial fibrosis (HP:0005576)2.77129849
52Prenatal maternal abnormality (HP:0002686)2.76847138
53Stomach cancer (HP:0012126)2.74614908
54Abnormality of methionine metabolism (HP:0010901)2.73434677
55Abnormality of dental color (HP:0011073)2.72273049
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.71044043
57Abnormality of the pancreatic islet cells (HP:0006476)2.70891805
58Abnormality of endocrine pancreas physiology (HP:0012093)2.70891805
59Abnormality of serine family amino acid metabolism (HP:0010894)2.70468587
60Abnormality of glycine metabolism (HP:0010895)2.70468587
61Fatigue (HP:0012378)2.69668861
62T lymphocytopenia (HP:0005403)2.68401469
63Abnormality of T cell number (HP:0011839)2.65113012
64Congenital stationary night blindness (HP:0007642)2.65060099
65Abnormality of macrophages (HP:0004311)2.64407124
66Severe combined immunodeficiency (HP:0004430)2.63790241
67Metabolic alkalosis (HP:0200114)2.62404817
68Hypokalemic alkalosis (HP:0001949)2.57866796
69Abnormality of the pleura (HP:0002103)2.57026171
70Increased purine levels (HP:0004368)2.56598154
71Hyperuricemia (HP:0002149)2.56598154
72Abnormality of homocysteine metabolism (HP:0010919)2.56172305
73Homocystinuria (HP:0002156)2.56172305
74Widely spaced teeth (HP:0000687)2.55945265
75Abnormal tarsal ossification (HP:0008369)2.55606785
76Abnormal rod and cone electroretinograms (HP:0008323)2.55246939
77Tongue fasciculations (HP:0001308)2.55224870
78Agammaglobulinemia (HP:0004432)2.51879716
79Abnormality of T cells (HP:0002843)2.51080477
80Encephalitis (HP:0002383)2.48987175
81Abnormality of T cell physiology (HP:0011840)2.47754716
82Acute hepatic failure (HP:0006554)2.46987581
83Dicarboxylic aciduria (HP:0003215)2.46187675
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.46187675
85Muscle fibrillation (HP:0010546)2.38701606
86Small epiphyses (HP:0010585)2.37760380
87Opisthotonus (HP:0002179)2.36705144
88Recurrent abscess formation (HP:0002722)2.36283827
89Mitral stenosis (HP:0001718)2.35879507
90Recurrent bacterial skin infections (HP:0005406)2.35432520
91Vacuolated lymphocytes (HP:0001922)2.35385009
92Pectus carinatum (HP:0000768)2.35188219
93Recurrent skin infections (HP:0001581)2.35163805
94Abnormality of aspartate family amino acid metabolism (HP:0010899)2.33204177
95Optic neuritis (HP:0100653)2.33021678
96Retrobulbar optic neuritis (HP:0100654)2.33021678
97Thoracic kyphosis (HP:0002942)2.30384867
98Thyroiditis (HP:0100646)2.29706840
99IgG deficiency (HP:0004315)2.29573920
100Progressive muscle weakness (HP:0003323)2.29244661
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.29110093
102Joint swelling (HP:0001386)2.28956938
103Abnormality of macular pigmentation (HP:0008002)2.28664174
104Acute encephalopathy (HP:0006846)2.26730431
105Type I transferrin isoform profile (HP:0003642)2.23965622
106Beaking of vertebral bodies (HP:0004568)2.23799174
107Redundant skin (HP:0001582)2.23379118
108Myocardial infarction (HP:0001658)2.22453382
109Pulmonary fibrosis (HP:0002206)2.21517849
110Hyperactive renin-angiotensin system (HP:0000841)2.20163696
111Orchitis (HP:0100796)2.19447429
112Inflammation of the large intestine (HP:0002037)2.19382138
113Recurrent viral infections (HP:0004429)2.16032662
114Hypoplasia of the odontoid process (HP:0003311)2.15401428
115Abnormality of the prostate (HP:0008775)2.14347725
116Abnormality of B cell number (HP:0010975)2.13124029
117Large hands (HP:0001176)2.10454653
118Cerebral edema (HP:0002181)2.07939947
119Disproportionate short-trunk short stature (HP:0003521)2.07267503
120Increased CSF protein (HP:0002922)2.07022576
121Recurrent bronchitis (HP:0002837)2.06596396
122Chronic hepatic failure (HP:0100626)2.06119204
123Colitis (HP:0002583)2.06072006
124Central scotoma (HP:0000603)2.05891124
125Type II lissencephaly (HP:0007260)2.05118826
126Meningitis (HP:0001287)2.05029156
127Albinism (HP:0001022)2.02553054
128Prostate neoplasm (HP:0100787)2.01563791
129Male infertility (HP:0003251)2.01392097
130Azoospermia (HP:0000027)2.01389030
131Hyperaldosteronism (HP:0000859)1.98964557
132Pulmonary infiltrates (HP:0002113)1.98579235
133Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97975165
134Barrel-shaped chest (HP:0001552)1.97562703
135Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96913087
136Recurrent pneumonia (HP:0006532)1.96023047
137Hyperammonemia (HP:0001987)1.95001637
138Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.94630394
139Congenital glaucoma (HP:0001087)1.94440588
140Hypoglycemic seizures (HP:0002173)1.94337870
141Hypochromic microcytic anemia (HP:0004840)1.94189405
142Gastrointestinal inflammation (HP:0004386)1.93792969
143Abnormality of fatty-acid metabolism (HP:0004359)1.93663043
144Enlarged kidneys (HP:0000105)1.93542503
145Villous atrophy (HP:0011473)1.93459765
146Abnormality of small intestinal villus morphology (HP:0011472)1.93459765
147Abnormality of the thoracic spine (HP:0100711)1.93396698
148Vasculitis (HP:0002633)1.93375708
149Abnormality of the lumbar spine (HP:0100712)1.92295961
150Dysostosis multiplex (HP:0000943)1.92250573
151Posterior subcapsular cataract (HP:0007787)1.91786524
152Increased IgE level (HP:0003212)1.91093811
153Cortical visual impairment (HP:0100704)1.90636194
154Chronic otitis media (HP:0000389)1.89370401
155Viral hepatitis (HP:0006562)1.89182162
156Abnormality of eosinophils (HP:0001879)1.86230291
157Lethargy (HP:0001254)1.85995168
158Glucose intolerance (HP:0000833)1.84608183
159Eosinophilia (HP:0001880)1.84110471
160Hypoplasia of the uterus (HP:0000013)1.83600674
161Constricted visual fields (HP:0001133)1.83374682
162Infantile muscular hypotonia (HP:0008947)1.82921809
163Metaphyseal dysplasia (HP:0100255)1.82031649
164Alveolar cell carcinoma (HP:0006519)1.81239831
165Mediastinal lymphadenopathy (HP:0100721)1.80093517
166Recurrent gram-negative bacterial infections (HP:0005420)1.79558622
167Coxa valga (HP:0002673)1.79437938
168Abnormality of the renal cortex (HP:0011035)1.79064838
169Granulocytopenia (HP:0001913)1.78363561
170Abnormality of renin-angiotensin system (HP:0000847)1.78156673
171Renal cortical cysts (HP:0000803)1.78140462
172B lymphocytopenia (HP:0010976)1.77652118
173Decreased circulating renin level (HP:0003351)1.77612795
174Median cleft lip (HP:0000161)1.77481558
175Amelogenesis imperfecta (HP:0000705)1.77164324
176Tubular atrophy (HP:0000092)1.77068412
177Abnormal foot bone ossification (HP:0010675)1.76848395
178Vascular calcification (HP:0004934)1.75461763
179Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.75198312
180Generalized aminoaciduria (HP:0002909)1.72386711
181Late onset (HP:0003584)1.71425527
182Hypokinesia (HP:0002375)1.71308783
183Periodontitis (HP:0000704)1.70755881
184Menorrhagia (HP:0000132)1.70496086
185Abnormality of the odontoid process (HP:0003310)1.70083571
186Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68967482
187Abnormality of purine metabolism (HP:0004352)1.68011390
188Renal salt wasting (HP:0000127)1.66838905
189Limb hypertonia (HP:0002509)1.65318094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK26.43119454
2ERN15.46547769
3EIF2AK34.48801219
4MST44.46396586
5MAP2K24.06676477
6BMPR1B3.62983953
7PKN22.96689598
8CDK82.70947510
9TRIB32.67528259
10MAPKAPK32.51886304
11TXK2.44057307
12EEF2K2.37307798
13FRK2.30263431
14ZAP702.13837556
15BCKDK10.2094328
16NME21.97947359
17TEC1.95907261
18INSRR1.92007823
19MAP3K31.83352900
20SIK31.83128053
21IRAK31.72160288
22FES1.68418032
23TGFBR11.63062299
24MAP2K11.61109622
25PIK3CA1.59879577
26JAK11.58256031
27IKBKB1.56062892
28PAK21.53664604
29ACVR1B1.51674791
30RPS6KB21.45252687
31RIPK41.44768610
32EPHA21.44485378
33ITK1.43942898
34SCYL21.39913884
35GRK61.37599783
36BLK1.36566914
37PASK1.35775904
38GRK11.29162929
39DYRK1A1.28266573
40MAP3K121.25009125
41PRKCQ1.19664187
42FLT31.19084296
43PIK3CG1.18025292
44NME11.17175351
45BTK1.15606698
46CDK191.14171619
47PRKG21.13651038
48PDK21.12339344
49OXSR11.09141155
50SYK1.07784865
51NEK61.05557928
52TAOK31.03784122
53BMPR21.00209466
54CSK0.96945400
55CDK90.96416213
56WNK40.95429105
57KIT0.95286692
58IRAK40.94922735
59PDGFRB0.94559612
60TNK20.93841394
61STK100.93575050
62LCK0.91119211
63NLK0.90476766
64PTK60.86332852
65MAP2K60.86155947
66CAMKK10.84086831
67MAPK120.83535628
68LYN0.82331575
69HIPK20.81245444
70MARK30.80130314
71SIK10.79108062
72TRIM280.77269398
73STK390.75754599
74MAPK150.74234018
75IKBKE0.73815787
76STK380.73411908
77RPS6KB10.71629788
78PINK10.71274030
79JAK30.69843530
80FER0.68404663
81PDK10.61487019
82HCK0.61434338
83IRAK20.59967118
84FGR0.59389469
85MTOR0.56561700
86LATS10.56532045
87PDPK10.55646609
88BRD40.53998458
89MAP2K30.53599997
90CSF1R0.53157302
91MAP4K10.52860514
92CAMKK20.52558894
93DAPK20.49472572
94GRK50.48967467
95MUSK0.47427190
96BRSK20.44568198
97CHUK0.43780281
98LRRK20.42242925
99FGFR30.42037755
100TBK10.41571173
101PRKCZ0.39465611
102MAPK30.37005380
103MELK0.36983653
104STK240.36613279
105ERBB20.35910531
106MAP3K90.35593273
107BCR0.35049072
108DYRK20.35042226
109RET0.34527676
110FGFR20.34241401
111TYK20.33975355
112MAPKAPK50.33388043
113TLK10.32893056
114STK30.32858289
115ILK0.32629626
116PRKACB0.31975516
117PRKCH0.31857461
118DYRK1B0.31440803
119PRKCE0.31142045
120ROCK10.30627373
121NEK90.28659921
122MAPK110.27325473
123DAPK10.27092548
124PIM20.27081779
125PRKAA20.26996380
126MATK0.26931150
127PRKCI0.26596073
128PAK30.26067811
129TRPM70.25724240
130RPS6KA10.24908908
131MAP3K80.22672337
132MAP2K70.21883165
133ABL10.21815170
134MAP3K70.21794386
135ADRBK20.21607574
136RAF10.21083025
137TGFBR20.18451409
138JAK20.17522462
139CSNK1G30.17472574
140IRAK10.15485538
141PTK20.14773416
142PRKD10.14340326
143PDK40.14067785
144PDK30.14067785
145STK160.13499598
146MAPK10.13166924
147NUAK10.12133041
148CSNK1A1L0.11302907
149CAMK1D0.11222946
150AKT10.10844056
151CSNK1G20.09086008
152IGF1R0.08941763
153KSR20.07521290
154EGFR0.06921843
155MAP3K140.06915108
156PIM10.06896453
157MAP3K20.06260381
158MAPK70.06197777
159EPHB10.06037637
160CSNK1G10.04861507
161MAPKAPK20.04749568
162RPS6KA50.04696136
163MAP3K10.04146821

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049728.36353100
2Fat digestion and absorption_Homo sapiens_hsa049755.90893874
3Protein digestion and absorption_Homo sapiens_hsa049745.54187722
4Protein export_Homo sapiens_hsa030603.59832278
5Folate biosynthesis_Homo sapiens_hsa007903.19203736
6Glycerolipid metabolism_Homo sapiens_hsa005612.94355806
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.88406173
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.83952933
9Primary immunodeficiency_Homo sapiens_hsa053402.73982866
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.50728829
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28260413
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.11181791
13Allograft rejection_Homo sapiens_hsa053302.03126182
14Graft-versus-host disease_Homo sapiens_hsa053322.01586771
15Propanoate metabolism_Homo sapiens_hsa006401.98276707
16Asthma_Homo sapiens_hsa053101.98118814
17Vitamin digestion and absorption_Homo sapiens_hsa049771.94700848
18Autoimmune thyroid disease_Homo sapiens_hsa053201.93339348
19Steroid biosynthesis_Homo sapiens_hsa001001.93077588
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89575211
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.81596708
22Staphylococcus aureus infection_Homo sapiens_hsa051501.79848924
23Hematopoietic cell lineage_Homo sapiens_hsa046401.54809633
24Type I diabetes mellitus_Homo sapiens_hsa049401.53497215
25Antigen processing and presentation_Homo sapiens_hsa046121.50643246
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.45688034
27T cell receptor signaling pathway_Homo sapiens_hsa046601.45476821
28Renin-angiotensin system_Homo sapiens_hsa046141.41636421
29Leishmaniasis_Homo sapiens_hsa051401.32109811
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31676590
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.30648986
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.30461872
33Arginine and proline metabolism_Homo sapiens_hsa003301.29548498
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27598100
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24802075
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18897734
37Linoleic acid metabolism_Homo sapiens_hsa005911.16479030
38Measles_Homo sapiens_hsa051621.15463066
39Circadian rhythm_Homo sapiens_hsa047101.12108276
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08082988
41Tuberculosis_Homo sapiens_hsa051521.04585269
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04539789
43B cell receptor signaling pathway_Homo sapiens_hsa046621.03793514
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03207339
45Biosynthesis of amino acids_Homo sapiens_hsa012301.02629891
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98092479
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.96882439
48Other glycan degradation_Homo sapiens_hsa005110.94849628
49Rheumatoid arthritis_Homo sapiens_hsa053230.94757543
50N-Glycan biosynthesis_Homo sapiens_hsa005100.93134551
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.91946062
52Phenylalanine metabolism_Homo sapiens_hsa003600.91923373
53Osteoclast differentiation_Homo sapiens_hsa043800.91775154
54Dorso-ventral axis formation_Homo sapiens_hsa043200.90791084
55Influenza A_Homo sapiens_hsa051640.88936716
56Starch and sucrose metabolism_Homo sapiens_hsa005000.88388259
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87862162
58Herpes simplex infection_Homo sapiens_hsa051680.86027277
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.85685289
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.83957429
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83509076
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82689803
63Selenocompound metabolism_Homo sapiens_hsa004500.79473797
64One carbon pool by folate_Homo sapiens_hsa006700.77379729
65Proteasome_Homo sapiens_hsa030500.74620820
66Collecting duct acid secretion_Homo sapiens_hsa049660.74549415
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73738423
68beta-Alanine metabolism_Homo sapiens_hsa004100.72097866
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70248887
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69786475
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69265613
72Notch signaling pathway_Homo sapiens_hsa043300.68755509
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68344631
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67834572
75Phototransduction_Homo sapiens_hsa047440.66868461
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64743056
77Complement and coagulation cascades_Homo sapiens_hsa046100.60315661
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57044914
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56876920
80Pyruvate metabolism_Homo sapiens_hsa006200.56488925
81Arachidonic acid metabolism_Homo sapiens_hsa005900.55052713
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54575918
83Fatty acid elongation_Homo sapiens_hsa000620.53654430
84Fatty acid degradation_Homo sapiens_hsa000710.52252054
85Fructose and mannose metabolism_Homo sapiens_hsa000510.51379202
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49596155
87TNF signaling pathway_Homo sapiens_hsa046680.49270902
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48292452
89Sphingolipid metabolism_Homo sapiens_hsa006000.47669418
90Ribosome_Homo sapiens_hsa030100.46732016
91Glutathione metabolism_Homo sapiens_hsa004800.46316994
92Ether lipid metabolism_Homo sapiens_hsa005650.45249311
93ABC transporters_Homo sapiens_hsa020100.45182906
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45067142
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44366565
96Legionellosis_Homo sapiens_hsa051340.43710630
97Tryptophan metabolism_Homo sapiens_hsa003800.42417386
98Tyrosine metabolism_Homo sapiens_hsa003500.41176027
99Sulfur relay system_Homo sapiens_hsa041220.40278517
100Vibrio cholerae infection_Homo sapiens_hsa051100.39927293
101Arginine biosynthesis_Homo sapiens_hsa002200.39376288
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39243054
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38826084
104Parkinsons disease_Homo sapiens_hsa050120.38794978
105Metabolic pathways_Homo sapiens_hsa011000.38712427
106Retinol metabolism_Homo sapiens_hsa008300.38489861
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38452633
108Sulfur metabolism_Homo sapiens_hsa009200.38245541
109Nitrogen metabolism_Homo sapiens_hsa009100.36993363
110Malaria_Homo sapiens_hsa051440.36819017
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35835784
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35678947
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.34213008
114Insulin secretion_Homo sapiens_hsa049110.33517025
115Chemokine signaling pathway_Homo sapiens_hsa040620.33005999
116African trypanosomiasis_Homo sapiens_hsa051430.31925998
117Alzheimers disease_Homo sapiens_hsa050100.31724792
118Pertussis_Homo sapiens_hsa051330.29387044
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28631227
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28365006
121Carbon metabolism_Homo sapiens_hsa012000.28258428
122RNA degradation_Homo sapiens_hsa030180.27878094
123Regulation of autophagy_Homo sapiens_hsa041400.24563826
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21535687
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19873781
126Lysosome_Homo sapiens_hsa041420.18893554
127Chemical carcinogenesis_Homo sapiens_hsa052040.18830185
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16184993
129Calcium signaling pathway_Homo sapiens_hsa040200.15948144
130Peroxisome_Homo sapiens_hsa041460.15902642
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14626717
132Histidine metabolism_Homo sapiens_hsa003400.14143093
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.12910124
134Fatty acid metabolism_Homo sapiens_hsa012120.12505391
135Oxidative phosphorylation_Homo sapiens_hsa001900.11992224
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11623671
137Endometrial cancer_Homo sapiens_hsa052130.11140986
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10980645
139VEGF signaling pathway_Homo sapiens_hsa043700.10345180
140Butanoate metabolism_Homo sapiens_hsa006500.08341820
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.08201874
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06400075
143Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.04890505
144Viral myocarditis_Homo sapiens_hsa054160.03899803
145Galactose metabolism_Homo sapiens_hsa000520.02181348
146Prostate cancer_Homo sapiens_hsa052150.01893638
147Toxoplasmosis_Homo sapiens_hsa051450.01714681
148Bile secretion_Homo sapiens_hsa04976-0.0506319
149Pancreatic cancer_Homo sapiens_hsa05212-0.0479352
150Platelet activation_Homo sapiens_hsa04611-0.0471858
151Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0417678
152RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0401846
153Hepatitis C_Homo sapiens_hsa05160-0.0155856
154Non-small cell lung cancer_Homo sapiens_hsa05223-0.0041973

Most similar genes based on co-expression Upload to Enrichr

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