ERP29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which localizes to the lumen of the endoplasmic reticulum (ER). It is a member of the protein disulfide isomerase (PDI) protein family but lacks an active thioredoxin motif, suggesting that this protein does not function as a disulfide isomerase. The canonical protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.81503620
2translational termination (GO:0006415)6.54731108
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.35363329
4cotranslational protein targeting to membrane (GO:0006613)6.26042567
5protein targeting to ER (GO:0045047)6.23875383
6ribosomal small subunit assembly (GO:0000028)6.13199368
7establishment of protein localization to endoplasmic reticulum (GO:0072599)5.93730559
8protein localization to endoplasmic reticulum (GO:0070972)5.86116613
9translational elongation (GO:0006414)5.62446730
10ribosomal small subunit biogenesis (GO:0042274)5.62123371
11DNA deamination (GO:0045006)5.42444859
12viral life cycle (GO:0019058)5.14509622
13cellular protein complex disassembly (GO:0043624)5.01438058
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.85998678
15translational initiation (GO:0006413)4.85230296
16maturation of SSU-rRNA (GO:0030490)4.37074811
17ribosomal large subunit biogenesis (GO:0042273)4.32628956
18protein complex disassembly (GO:0043241)4.31493536
19telomere maintenance via semi-conservative replication (GO:0032201)4.24228240
20protein targeting to membrane (GO:0006612)4.18853104
21DNA strand elongation involved in DNA replication (GO:0006271)4.10115913
22translation (GO:0006412)4.08429118
23macromolecular complex disassembly (GO:0032984)4.08280635
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.03606441
25DNA strand elongation (GO:0022616)3.85431101
26oligosaccharide catabolic process (GO:0009313)3.82581233
27Arp2/3 complex-mediated actin nucleation (GO:0034314)3.82549920
28neutrophil activation involved in immune response (GO:0002283)3.76525278
29telomere maintenance via recombination (GO:0000722)3.67942083
30Golgi transport vesicle coating (GO:0048200)3.57371617
31COPI coating of Golgi vesicle (GO:0048205)3.57371617
32antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.56639649
33respiratory burst (GO:0045730)3.55941611
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.52578276
35regulation of superoxide anion generation (GO:0032928)3.49705470
36nuclear-transcribed mRNA catabolic process (GO:0000956)3.46463188
37GDP-mannose metabolic process (GO:0019673)3.42176213
38formation of translation preinitiation complex (GO:0001731)3.41166804
39negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.40461658
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.39027572
41glycosphingolipid catabolic process (GO:0046479)3.36126009
42neutrophil mediated immunity (GO:0002446)3.32688437
43amino sugar catabolic process (GO:0046348)3.32486741
44DNA replication checkpoint (GO:0000076)3.29316232
45mRNA catabolic process (GO:0006402)3.28668480
46mitotic recombination (GO:0006312)3.25011584
47ribonucleoprotein complex biogenesis (GO:0022613)3.23875399
48regulation of protein heterodimerization activity (GO:0043497)3.23669080
49DNA replication initiation (GO:0006270)3.22912544
50signal peptide processing (GO:0006465)3.22717889
51L-alpha-amino acid transmembrane transport (GO:1902475)3.18006959
52DNA unwinding involved in DNA replication (GO:0006268)3.16986692
53RNA catabolic process (GO:0006401)3.10118075
54negative regulation of phagocytosis (GO:0050765)3.08788726
55mannose metabolic process (GO:0006013)3.07049926
56immunoglobulin mediated immune response (GO:0016064)3.03972073
57glycolipid catabolic process (GO:0019377)3.02571289
58lipopolysaccharide metabolic process (GO:0008653)3.00031368
59regulation of interferon-beta biosynthetic process (GO:0045357)2.99419697
60response to thyroid hormone (GO:0097066)2.98718953
61negative regulation of erythrocyte differentiation (GO:0045647)2.97357717
62NADPH regeneration (GO:0006740)2.97069820
63nucleotide-excision repair, DNA gap filling (GO:0006297)2.94782469
64maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.94767987
65telomere maintenance via telomere lengthening (GO:0010833)2.93809463
66cellular response to interferon-beta (GO:0035458)2.90025179
67establishment of protein localization to membrane (GO:0090150)2.89474543
68ncRNA 3-end processing (GO:0043628)2.87467217
69pentose metabolic process (GO:0019321)2.87378376
70activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.87129194
71mitotic nuclear envelope reassembly (GO:0007084)2.85794877
72nuclear envelope reassembly (GO:0031468)2.85794877
73glucose catabolic process (GO:0006007)2.84687172
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84009123
75protein maturation by protein folding (GO:0022417)2.83161409
76rRNA processing (GO:0006364)2.81050202
77lipopolysaccharide biosynthetic process (GO:0009103)2.79339690
78antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.79037750
79protein retention in ER lumen (GO:0006621)2.78437603
80pseudouridine synthesis (GO:0001522)2.78138198
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77946526
82protein targeting (GO:0006605)2.76190058
83pinocytosis (GO:0006907)2.76046594
84amyloid precursor protein catabolic process (GO:0042987)2.73198910
85proline biosynthetic process (GO:0006561)2.72662578
86negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.72469719
87actin nucleation (GO:0045010)2.72036021
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.71759562
89response to peptidoglycan (GO:0032494)2.71031792
90GTP biosynthetic process (GO:0006183)2.67955023
91rRNA metabolic process (GO:0016072)2.67073698
92negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.66587606
93glucose 6-phosphate metabolic process (GO:0051156)2.66361646
94response to interferon-beta (GO:0035456)2.65539300
95pentose-phosphate shunt (GO:0006098)2.65072995
96negative regulation of myeloid cell apoptotic process (GO:0033033)2.64999543
97leukocyte mediated cytotoxicity (GO:0001909)2.61860627
98purine ribonucleotide transport (GO:0015868)2.61773751
99positive regulation of B cell differentiation (GO:0045579)2.61404270
100energy coupled proton transport, down electrochemical gradient (GO:0015985)2.61102622
101ATP synthesis coupled proton transport (GO:0015986)2.61102622
102antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.60616502
103antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.60616502
104antigen processing and presentation of endogenous antigen (GO:0019883)2.59614778
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.57490056
106establishment of protein localization to organelle (GO:0072594)2.57072191
107N-acetylneuraminate metabolic process (GO:0006054)2.56918705
108cellular component biogenesis (GO:0044085)2.55814426
109sphingolipid catabolic process (GO:0030149)2.54860563
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.54714696
111negative regulation of ligase activity (GO:0051352)2.54714696
112UTP biosynthetic process (GO:0006228)2.54285311
113regulation of B cell receptor signaling pathway (GO:0050855)2.54082215
114myeloid leukocyte mediated immunity (GO:0002444)2.53972689
115B cell mediated immunity (GO:0019724)2.53575529
116establishment of viral latency (GO:0019043)2.52343499
117response to fungus (GO:0009620)2.52197245
118DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.52097392
119ceramide catabolic process (GO:0046514)2.51644459
120cellular response to thyroid hormone stimulus (GO:0097067)2.51064324
121pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.50588273
122cellular response to zinc ion (GO:0071294)2.48929381
123intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.47686445
124signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.47686445
125positive regulation of antigen processing and presentation (GO:0002579)2.46251608
126regulation of translational fidelity (GO:0006450)2.44943881
127nucleobase-containing small molecule interconversion (GO:0015949)2.43492820
128signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.43472646
129signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.43472646
130signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.43472646
131membrane lipid catabolic process (GO:0046466)2.43267056
132establishment of integrated proviral latency (GO:0075713)2.42997549
133CTP biosynthetic process (GO:0006241)2.40436137
134CTP metabolic process (GO:0046036)2.40436137
135erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.35959619
136L-phenylalanine metabolic process (GO:0006558)2.35959619
137viral protein processing (GO:0019082)2.34315740
138regulation of autophagic vacuole assembly (GO:2000785)2.33754616
139regulation of extracellular matrix disassembly (GO:0010715)2.32610293
140myeloid cell homeostasis (GO:0002262)2.32111032
141endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.30688764
142regulation of mitochondrial translation (GO:0070129)2.28362063
143regulation of lipoprotein particle clearance (GO:0010984)2.21899715
144respiratory electron transport chain (GO:0022904)2.21432976
145adenine nucleotide transport (GO:0051503)2.20320965
146modulation by symbiont of host immune response (GO:0052553)2.18616284
147positive regulation by symbiont of host defense response (GO:0052509)2.18616284
148modulation by symbiont of host defense response (GO:0052031)2.18616284
149modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.18616284
150modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.18616284
151positive regulation by organism of defense response of other organism involved in symbiotic interact2.18616284
152modulation by virus of host process (GO:0019054)2.16192076
153electron transport chain (GO:0022900)2.15686470
154regulation of B cell apoptotic process (GO:0002902)2.15539461
155oxidative phosphorylation (GO:0006119)2.15066394
156detection of bacterium (GO:0016045)2.14773775
157modulation by symbiont of host cellular process (GO:0044068)2.11515525
158regulation of cholesterol esterification (GO:0010872)2.11017546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.52781399
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.05700171
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.01331846
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.62081758
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.06124037
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02317269
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90280248
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.87019136
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.83965395
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.78155820
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.76291048
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.66664107
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64472567
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.54916266
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49854118
16* IRF8_21731497_ChIP-ChIP_J774_Mouse2.46970058
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43310272
18VDR_21846776_ChIP-Seq_THP-1_Human2.43008352
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37369698
20* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26923157
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.26415779
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.22880455
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22127967
24XRN2_22483619_ChIP-Seq_HELA_Human2.20695293
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15083477
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13910781
27VDR_23849224_ChIP-Seq_CD4+_Human2.12164383
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08399338
29* DCP1A_22483619_ChIP-Seq_HELA_Human2.05255554
30* SPI1_23547873_ChIP-Seq_NB4_Human2.02957761
31SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.92230342
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.91133065
33* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87141873
34* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.86868454
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.86794397
36* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.86754869
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86615604
38TTF2_22483619_ChIP-Seq_HELA_Human1.85898866
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82646565
40FOXP3_21729870_ChIP-Seq_TREG_Human1.81656029
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81482015
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80592850
43MYC_22102868_ChIP-Seq_BL_Human1.79020930
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77849417
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.75494948
46LXR_22292898_ChIP-Seq_THP-1_Human1.74598997
47GABP_19822575_ChIP-Seq_HepG2_Human1.72892791
48* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69197637
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68605446
50* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65637627
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65384121
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63748487
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63735966
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62914655
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58679327
56VDR_24763502_ChIP-Seq_THP-1_Human1.55390515
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55389592
58ZNF263_19887448_ChIP-Seq_K562_Human1.55282263
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.54890390
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52680389
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.52028754
62* IRF8_27001747_Chip-Seq_BMDM_Mouse1.50508211
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50362729
64CIITA_25753668_ChIP-Seq_RAJI_Human1.49289265
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.45112810
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.42476178
67ELK1_19687146_ChIP-ChIP_HELA_Human1.38951992
68RACK7_27058665_Chip-Seq_MCF-7_Human1.38207775
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36828230
70SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36530216
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.35296650
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34211273
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33554256
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32922414
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31423959
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31072379
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30531043
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29832097
79SCL_19346495_ChIP-Seq_HPC-7_Human1.28662957
80* RUNX1_22412390_ChIP-Seq_EML_Mouse1.26262797
81* TFEB_21752829_ChIP-Seq_HELA_Human1.26102111
82* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25996685
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25858833
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24629969
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.21746693
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.21276869
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20860797
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20533916
89* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19785660
90* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18296623
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17817994
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17429613
93NCOR1_26117541_ChIP-Seq_K562_Human1.17154541
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17081198
95TET1_21451524_ChIP-Seq_MESCs_Mouse1.15812517
96PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15551495
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.14861948
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14509265
99P68_20966046_ChIP-Seq_HELA_Human1.12020795
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11943159
101RXR_22158963_ChIP-Seq_LIVER_Mouse1.11637679
102PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10909888
103CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10417552
104KDM5A_27292631_Chip-Seq_BREAST_Human1.09272122
105PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09209094
106* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08918441
107BCOR_27268052_Chip-Seq_Bcells_Human1.08769272
108MAF_26560356_Chip-Seq_TH1_Human1.08402341
109POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07386016
110* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05762329
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05179234
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03837880
113UTX_26944678_Chip-Seq_JUKART_Human1.01804718
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01659484
115TCF7_22412390_ChIP-Seq_EML_Mouse1.01104870
116CTCF_26484167_Chip-Seq_Bcells_Mouse1.00049492
117FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99396785
118MYB_26560356_Chip-Seq_TH2_Human0.98318951
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97718847
120* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97587859
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97312290
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97100196
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95693920
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95194977
125SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94289699
126MAF_26560356_Chip-Seq_TH2_Human0.94032286
127LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93259211
128NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92997973

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.93288391
2MP0002139_abnormal_hepatobiliary_system3.47524491
3MP0003693_abnormal_embryo_hatching3.32220212
4MP0005058_abnormal_lysosome_morphology3.16996325
5MP0003303_peritoneal_inflammation3.02659745
6MP0003436_decreased_susceptibility_to2.97104113
7MP0009840_abnormal_foam_cell2.96367466
8MP0009379_abnormal_foot_pigmentation2.77739647
9MP0002148_abnormal_hypersensitivity_rea2.64421688
10MP0005174_abnormal_tail_pigmentation2.59359179
11MP0003806_abnormal_nucleotide_metabolis2.56058657
12MP0002396_abnormal_hematopoietic_system2.53258797
13MP0005000_abnormal_immune_tolerance2.48404240
14MP0002419_abnormal_innate_immunity2.44438737
15MP0003172_abnormal_lysosome_physiology2.38921992
16MP0005025_abnormal_response_to2.38534602
17MP0004957_abnormal_blastocyst_morpholog2.36160464
18MP0009333_abnormal_splenocyte_physiolog2.31118440
19MP0002452_abnormal_antigen_presenting2.29034417
20MP0001800_abnormal_humoral_immune2.18419511
21MP0009785_altered_susceptibility_to2.16451955
22MP0000490_abnormal_crypts_of2.14592079
23MP0002420_abnormal_adaptive_immunity2.12078461
24MP0001819_abnormal_immune_cell2.10014774
25MP0000685_abnormal_immune_system2.07907737
26MP0005365_abnormal_bile_salt2.07468469
27MP0002723_abnormal_immune_serum2.04480579
28MP0005451_abnormal_body_composition2.03557238
29MP0003183_abnormal_peptide_metabolism1.94510341
30MP0006054_spinal_hemorrhage1.93707988
31MP0005387_immune_system_phenotype1.91314380
32MP0001790_abnormal_immune_system1.91314380
33MP0002398_abnormal_bone_marrow1.80674373
34MP0005671_abnormal_response_to1.80182315
35MP0002254_reproductive_system_inflammat1.79916827
36MP0000858_altered_metastatic_potential1.77033844
37MP0000716_abnormal_immune_system1.73419945
38MP0003724_increased_susceptibility_to1.69387256
39MP0008057_abnormal_DNA_replication1.69244343
40MP0000689_abnormal_spleen_morphology1.64442609
41MP0001853_heart_inflammation1.64271502
42MP0002429_abnormal_blood_cell1.62599449
43MP0002405_respiratory_system_inflammati1.60167454
44MP0005464_abnormal_platelet_physiology1.59466985
45MP0003077_abnormal_cell_cycle1.58073781
46MP0003111_abnormal_nucleus_morphology1.56139572
47MP0002722_abnormal_immune_system1.55272499
48MP0001533_abnormal_skeleton_physiology1.53014544
49MP0001845_abnormal_inflammatory_respons1.51331210
50MP0008260_abnormal_autophagy1.48757327
51MP0010094_abnormal_chromosome_stability1.47378796
52MP0004808_abnormal_hematopoietic_stem1.46896417
53MP0003866_abnormal_defecation1.44758222
54MP0000015_abnormal_ear_pigmentation1.43347432
55MP0006082_CNS_inflammation1.42266878
56MP0004019_abnormal_vitamin_homeostasis1.40549763
57MP0008058_abnormal_DNA_repair1.39834610
58MP0005075_abnormal_melanosome_morpholog1.37336099
59MP0005310_abnormal_salivary_gland1.36756618
60MP0002166_altered_tumor_susceptibility1.36012669
61MP0008438_abnormal_cutaneous_collagen1.35288324
62MP0001545_abnormal_hematopoietic_system1.34690731
63MP0005397_hematopoietic_system_phenotyp1.34690731
64MP0010234_abnormal_vibrissa_follicle1.34075000
65MP0003123_paternal_imprinting1.33453742
66MP0000465_gastrointestinal_hemorrhage1.30795139
67MP0008932_abnormal_embryonic_tissue1.29833707
68MP0008469_abnormal_protein_level1.28116614
69MP0005360_urolithiasis1.26049774
70MP0003075_altered_response_to1.24386285
71MP0000358_abnormal_cell_content/1.23143812
72MP0010307_abnormal_tumor_latency1.22307138
73MP0008007_abnormal_cellular_replicative1.21933566
74MP0005379_endocrine/exocrine_gland_phen1.21518174
75MP0001764_abnormal_homeostasis1.19883167
76MP0005408_hypopigmentation1.19230544
77MP0010155_abnormal_intestine_physiology1.17127378
78MP0003763_abnormal_thymus_physiology1.16575264
79MP0002095_abnormal_skin_pigmentation1.16015092
80MP0003453_abnormal_keratinocyte_physiol1.15847376
81MP0002019_abnormal_tumor_incidence1.15119130
82MP0000678_abnormal_parathyroid_gland1.13503475
83MP0000609_abnormal_liver_physiology1.11251112
84MP0000703_abnormal_thymus_morphology1.10762341
85MP0003448_altered_tumor_morphology1.10084446
86MP0005319_abnormal_enzyme/_coenzyme1.09432650
87MP0003329_amyloid_beta_deposits1.08518089
88MP0002796_impaired_skin_barrier1.06466056
89MP0002006_tumorigenesis1.06215980
90MP0002877_abnormal_melanocyte_morpholog1.04014288
91MP0005257_abnormal_intraocular_pressure0.98842245
92MP0000313_abnormal_cell_death0.98754665
93MP0006035_abnormal_mitochondrial_morpho0.96431286
94MP0009643_abnormal_urine_homeostasis0.95794373
95MP0005501_abnormal_skin_physiology0.95788886
96MP0000343_altered_response_to0.94821197
97MP0003191_abnormal_cellular_cholesterol0.92037168
98MP0005083_abnormal_biliary_tract0.90434422
99MP0004264_abnormal_extraembryonic_tissu0.89189825
100MP0003656_abnormal_erythrocyte_physiolo0.88778947
101MP0002933_joint_inflammation0.88028509
102MP0009672_abnormal_birth_weight0.87025310
103MP0000598_abnormal_liver_morphology0.86956710
104MP0002277_abnormal_respiratory_mucosa0.85474859
105MP0003186_abnormal_redox_activity0.84966788
106MP0005584_abnormal_enzyme/coenzyme_acti0.83268460
107MP0001730_embryonic_growth_arrest0.82747345
108MP0005164_abnormal_response_to0.82703487
109MP0005332_abnormal_amino_acid0.82484160
110MP0005084_abnormal_gallbladder_morpholo0.81717734
111MP0002163_abnormal_gland_morphology0.80211152
112MP0001727_abnormal_embryo_implantation0.79085400
113MP0008875_abnormal_xenobiotic_pharmacok0.78998125
114MP0001666_abnormal_nutrient_absorption0.78753241
115MP0004185_abnormal_adipocyte_glucose0.77565379
116MP0000681_abnormal_thyroid_gland0.77338586
117MP0009278_abnormal_bone_marrow0.76600182
118MP0005390_skeleton_phenotype0.75562010
119MP0001663_abnormal_digestive_system0.75219723
120MP0003795_abnormal_bone_structure0.74938264
121MP0003300_gastrointestinal_ulcer0.74551449
122MP0004947_skin_inflammation0.74214431
123MP0000350_abnormal_cell_proliferation0.74210345
124MP0001873_stomach_inflammation0.70118464
125MP0003566_abnormal_cell_adhesion0.69230191
126MP0002693_abnormal_pancreas_physiology0.69168117
127MP0002998_abnormal_bone_remodeling0.67109439
128MP0002132_abnormal_respiratory_system0.66358288
129MP0008873_increased_physiological_sensi0.63948175
130MP0005384_cellular_phenotype0.62518015
131MP0005220_abnormal_exocrine_pancreas0.62031278
132MP0000604_amyloidosis0.60889770
133MP0001542_abnormal_bone_strength0.60880288
134MP0003786_premature_aging0.58435924
135MP0002135_abnormal_kidney_morphology0.57609103
136MP0003122_maternal_imprinting0.57201551
137MP0006036_abnormal_mitochondrial_physio0.56607898

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.96713862
2Abnormal number of erythroid precursors (HP:0012131)5.58317671
3Recurrent abscess formation (HP:0002722)4.86594595
4Reticulocytopenia (HP:0001896)4.76560449
5Vacuolated lymphocytes (HP:0001922)4.72276105
6Recurrent bacterial skin infections (HP:0005406)4.34471474
7Thrombocytosis (HP:0001894)4.04330991
8Elevated erythrocyte sedimentation rate (HP:0003565)3.84162965
9Pallor (HP:0000980)3.83488515
10Macrocytic anemia (HP:0001972)3.78218920
11Eczematoid dermatitis (HP:0000976)3.53387728
12Loss of speech (HP:0002371)3.33381424
13Type I transferrin isoform profile (HP:0003642)3.31434278
14Chronic obstructive pulmonary disease (HP:0006510)3.20274816
15Obstructive lung disease (HP:0006536)3.20274816
16Poor head control (HP:0002421)3.18486588
17Dysostosis multiplex (HP:0000943)3.17889415
18Petechiae (HP:0000967)3.15819664
19Abnormality of macrophages (HP:0004311)3.15269875
20IgM deficiency (HP:0002850)3.14891441
21Agnosia (HP:0010524)3.06969989
22Progressive neurologic deterioration (HP:0002344)3.04627149
23Exertional dyspnea (HP:0002875)3.00398535
24Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.95575013
25Increased neuronal autofluorescent lipopigment (HP:0002074)2.89673070
26Increased cerebral lipofuscin (HP:0011813)2.87198612
27Mitochondrial inheritance (HP:0001427)2.85896552
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.85357971
29Abnormality of aromatic amino acid family metabolism (HP:0004338)2.85110519
30Urinary glycosaminoglycan excretion (HP:0003541)2.83335463
31Mucopolysacchariduria (HP:0008155)2.83335463
32Reduced antithrombin III activity (HP:0001976)2.80536209
33Hepatocellular necrosis (HP:0001404)2.79690318
34Increased hepatocellular lipid droplets (HP:0006565)2.78531273
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.76364865
36Abnormal protein N-linked glycosylation (HP:0012347)2.76364865
37Abnormal protein glycosylation (HP:0012346)2.76364865
38Abnormal glycosylation (HP:0012345)2.76364865
39Myositis (HP:0100614)2.73684564
40Acute necrotizing encephalopathy (HP:0006965)2.73345108
41Abnormality of glycolipid metabolism (HP:0010969)2.68297451
42Abnormality of liposaccharide metabolism (HP:0010968)2.68297451
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.68297451
44Recurrent skin infections (HP:0001581)2.61383196
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60890380
46Abnormality of glycosaminoglycan metabolism (HP:0004371)2.50165229
47Abnormality of mucopolysaccharide metabolism (HP:0011020)2.50165229
48Abnormality of polysaccharide metabolism (HP:0011012)2.50165229
49Purpura (HP:0000979)2.45764247
50Cellulitis (HP:0100658)2.44733898
51Abnormal mitochondria in muscle tissue (HP:0008316)2.44410651
52Deep venous thrombosis (HP:0002625)2.40996945
53Hepatic necrosis (HP:0002605)2.38953816
54Recurrent gram-negative bacterial infections (HP:0005420)2.38779245
55Lipid accumulation in hepatocytes (HP:0006561)2.38287774
56Meningitis (HP:0001287)2.37391220
57Prolonged neonatal jaundice (HP:0006579)2.35799977
58Increased CSF lactate (HP:0002490)2.31808445
59Aplastic anemia (HP:0001915)2.30434707
60Recurrent viral infections (HP:0004429)2.28127163
61Renal Fanconi syndrome (HP:0001994)2.27294292
62Mediastinal lymphadenopathy (HP:0100721)2.26908699
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.26412451
64Decreased activity of mitochondrial respiratory chain (HP:0008972)2.26412451
65Hypoglycemic seizures (HP:0002173)2.26275808
66Increased serum ferritin (HP:0003281)2.25713450
67Thoracic kyphosis (HP:0002942)2.23793731
68Microretrognathia (HP:0000308)2.23549543
69J-shaped sella turcica (HP:0002680)2.23390724
70Xanthomatosis (HP:0000991)2.21733611
71Hepatosplenomegaly (HP:0001433)2.19568001
72Abnormality of T cell physiology (HP:0011840)2.19171208
73Cardiomegaly (HP:0001640)2.17134790
74Hyperinsulinemic hypoglycemia (HP:0000825)2.15356086
75Chronic otitis media (HP:0000389)2.14721120
76Hypokinesia (HP:0002375)2.14691980
77Systemic lupus erythematosus (HP:0002725)2.13535312
78Amyloidosis (HP:0011034)2.13501479
79Gastrointestinal inflammation (HP:0004386)2.12993476
80Basal ganglia calcification (HP:0002135)2.11028957
81Hypertensive crisis (HP:0100735)2.07587555
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07572437
83Inflammation of the large intestine (HP:0002037)2.07524628
84Hypoglycemic coma (HP:0001325)2.06390085
85Progressive macrocephaly (HP:0004481)2.06086888
86Microvesicular hepatic steatosis (HP:0001414)2.05592983
87Abnormality of reticulocytes (HP:0004312)2.04936892
88Progressive muscle weakness (HP:0003323)2.04410150
89Nuclear cataract (HP:0100018)2.03734616
90Colitis (HP:0002583)2.02800107
91Recurrent fungal infections (HP:0002841)2.01769931
92Polygenic inheritance (HP:0010982)2.01458494
93Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00122989
94Interstitial pulmonary disease (HP:0006530)1.97239058
95Recurrent lower respiratory tract infections (HP:0002783)1.96751154
96Recurrent pneumonia (HP:0006532)1.96499999
97Acute encephalopathy (HP:0006846)1.95640632
98Abnormality of the thoracic spine (HP:0100711)1.93756889
99Vertebral compression fractures (HP:0002953)1.93058809
100Disinhibition (HP:0000734)1.92830303
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91378469
102Prolonged partial thromboplastin time (HP:0003645)1.91344937
103Abnormality of the anterior horn cell (HP:0006802)1.91053707
104Degeneration of anterior horn cells (HP:0002398)1.91053707
105Pathologic fracture (HP:0002756)1.90913994
106Orthostatic hypotension (HP:0001278)1.90596465
107Glomerulonephritis (HP:0000099)1.89408381
108Gingivitis (HP:0000230)1.89022321
109Seborrheic dermatitis (HP:0001051)1.88991419
110Symptomatic seizures (HP:0011145)1.88627545
111Cholecystitis (HP:0001082)1.88293918
112Abnormal gallbladder physiology (HP:0012438)1.88293918
113Increased intramyocellular lipid droplets (HP:0012240)1.86417348
114Nonimmune hydrops fetalis (HP:0001790)1.86363298
115Multiple enchondromatosis (HP:0005701)1.85829257
116Abnormality of complement system (HP:0005339)1.85465672
117Beaking of vertebral bodies (HP:0004568)1.85239719
118Personality changes (HP:0000751)1.84493608
119Increased IgE level (HP:0003212)1.83654722
120Abnormal platelet function (HP:0011869)1.83439837
121Impaired platelet aggregation (HP:0003540)1.83439837
122Axonal loss (HP:0003447)1.82430446
123Oral leukoplakia (HP:0002745)1.81011326
124Vasculitis (HP:0002633)1.80762289
125Testicular atrophy (HP:0000029)1.80171388
126Respiratory failure (HP:0002878)1.79815925
127Cutaneous photosensitivity (HP:0000992)1.78394298
128Hypergammaglobulinemia (HP:0010702)1.77400784
129Complement deficiency (HP:0004431)1.77249975
130Urticaria (HP:0001025)1.75871952
131Pulmonary fibrosis (HP:0002206)1.75826466
132Osteomyelitis (HP:0002754)1.75640968
133Villous atrophy (HP:0011473)1.74910905
134Abnormality of small intestinal villus morphology (HP:0011472)1.74910905
135Severe visual impairment (HP:0001141)1.74904640
136Abnormality of the prostate (HP:0008775)1.74041427
137Hypergonadotropic hypogonadism (HP:0000815)1.73433624
138Birth length less than 3rd percentile (HP:0003561)1.73084359
139Abnormality of the Achilles tendon (HP:0005109)1.70006986
140Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.68940859
141Respiratory difficulties (HP:0002880)1.67936432
142Progressive external ophthalmoplegia (HP:0000590)1.65570116
143Lower limb hyperreflexia (HP:0002395)1.65410952
144Abnormality of iron homeostasis (HP:0011031)1.64797125
145Gastrointestinal stroma tumor (HP:0100723)1.63448561
146Achilles tendon contracture (HP:0001771)1.61759312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.27575526
2BLK3.38716616
3VRK23.33090138
4STK163.04256194
5PIM22.90738005
6EIF2AK32.90603031
7TLK12.88286762
8SMG12.84526964
9IRAK42.51453334
10SCYL22.44972607
11ERN12.37079903
12KIT2.22460315
13MAP4K12.17123674
14BUB12.09941199
15PRPF4B2.01623319
16CDK121.98805950
17WEE11.91425624
18FLT31.82171629
19TBK11.79349400
20VRK11.78861306
21TYK21.78799870
22ARAF1.72913805
23IRAK31.72577786
24CSF1R1.71421290
25BTK1.70436700
26FES1.66961717
27TEC1.59968583
28TESK21.50932765
29SYK1.47259830
30ZAP701.42887797
31LRRK21.40680890
32EIF2AK11.38488627
33PDK21.33649429
34MAP3K111.28292028
35FGFR41.27300067
36TAOK21.25259099
37MAP3K141.23874982
38DYRK31.22988488
39ICK1.18642786
40MATK1.18391665
41SIK11.17778571
42RPS6KA41.17290151
43PASK1.16388850
44LYN1.13950122
45RIPK41.12752416
46CDK191.11053010
47MAP3K101.09580028
48GRK61.08651845
49TESK11.07034514
50CDC71.04602501
51TGFBR21.01617304
52ACVR1B1.01610199
53EPHA21.00808120
54BRAF1.00433039
55IRAK20.99734572
56TAOK10.99651735
57PKN20.99031972
58IKBKB0.95373834
59PAK40.93820826
60KDR0.93270820
61MST40.92088318
62CLK10.90812630
63MAPKAPK30.90622597
64MAP3K10.90361129
65EIF2AK20.89627215
66NEK20.89622733
67MAP2K30.83944430
68TGFBR10.83926309
69CAMKK20.83868329
70TNK20.83856414
71TAOK30.83106800
72MAP3K80.81070923
73CDK70.75757920
74LCK0.75658647
75ADRBK20.74001178
76BMX0.71676045
77RPS6KB20.71366167
78BCKDK0.70754937
79CDK80.70724284
80PTK60.69285374
81TTK0.68494544
82ILK0.68418390
83IKBKE0.68317358
84SRPK10.68153395
85PIM10.66936840
86NME10.66251947
87HCK0.65822247
88STK100.64987264
89JAK30.64955229
90ABL20.64453166
91EEF2K0.63903209
92AURKB0.63886705
93CDK60.63770613
94PDPK10.63522734
95PAK10.62834537
96PRKD20.61891734
97AURKA0.61704694
98MAPK110.61363778
99MAP3K130.60661280
100MAP2K20.60366349
101DAPK10.60302049
102NEK90.60050777
103MAP3K120.60035965
104DAPK30.60004377
105YES10.57608107
106FGR0.57524880
107PRKG20.55728279
108CSK0.54574313
109STK40.54043494
110ITK0.53356914
111CSNK2A10.53223836
112ATR0.52665551
113RPS6KA60.51735599
114CSNK2A20.51495790
115TRIB30.49825398
116RPS6KA50.49755537
117GRK70.48795734
118RPS6KL10.48771025
119RPS6KC10.48771025
120PLK10.48684076
121LMTK20.46420709
122PLK40.45888007
123MKNK10.45477508
124PRKCD0.44927775
125HIPK20.43024980
126MAPKAPK20.41773436
127CDK40.41546548
128ALK0.40960861
129EPHB10.40187300
130MAP3K30.39457036
131MAPKAPK50.38104849
132BMPR20.38101131

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.40861123
2DNA replication_Homo sapiens_hsa030303.98745210
3Protein export_Homo sapiens_hsa030603.29444158
4Proteasome_Homo sapiens_hsa030503.07197369
5Mismatch repair_Homo sapiens_hsa034302.85455915
6Other glycan degradation_Homo sapiens_hsa005112.64988578
7Base excision repair_Homo sapiens_hsa034102.20530385
8Oxidative phosphorylation_Homo sapiens_hsa001902.17361694
9Homologous recombination_Homo sapiens_hsa034402.10463934
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.07230256
11RNA polymerase_Homo sapiens_hsa030201.98992388
12Nucleotide excision repair_Homo sapiens_hsa034201.91242937
13Pyrimidine metabolism_Homo sapiens_hsa002401.88710127
14Spliceosome_Homo sapiens_hsa030401.87618338
15N-Glycan biosynthesis_Homo sapiens_hsa005101.83749983
16Parkinsons disease_Homo sapiens_hsa050121.79965119
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79441212
18Lysosome_Homo sapiens_hsa041421.76940617
19Fructose and mannose metabolism_Homo sapiens_hsa000511.69042026
20Antigen processing and presentation_Homo sapiens_hsa046121.61446407
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57009327
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44001787
23Leishmaniasis_Homo sapiens_hsa051401.32774901
24Huntingtons disease_Homo sapiens_hsa050161.29321486
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27506187
26Alzheimers disease_Homo sapiens_hsa050101.26281103
27* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23392105
28Biosynthesis of amino acids_Homo sapiens_hsa012301.23325475
29Type I diabetes mellitus_Homo sapiens_hsa049401.23042132
30Sulfur relay system_Homo sapiens_hsa041221.21878129
31Carbon metabolism_Homo sapiens_hsa012001.20107559
32Phagosome_Homo sapiens_hsa041451.19952717
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19453606
34Autoimmune thyroid disease_Homo sapiens_hsa053201.15842477
35Allograft rejection_Homo sapiens_hsa053301.15487781
36RNA transport_Homo sapiens_hsa030131.13913315
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13383632
38Legionellosis_Homo sapiens_hsa051341.11384330
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.10825005
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09945811
41One carbon pool by folate_Homo sapiens_hsa006701.07240688
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05614929
43Fatty acid elongation_Homo sapiens_hsa000621.05347436
44Pertussis_Homo sapiens_hsa051331.04114816
45Systemic lupus erythematosus_Homo sapiens_hsa053221.03891222
46Vibrio cholerae infection_Homo sapiens_hsa051101.03870482
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01261705
48Fanconi anemia pathway_Homo sapiens_hsa034601.00203406
49B cell receptor signaling pathway_Homo sapiens_hsa046620.96463169
50Cell cycle_Homo sapiens_hsa041100.95290159
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95091495
52Tuberculosis_Homo sapiens_hsa051520.94278921
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.93743576
54Prion diseases_Homo sapiens_hsa050200.93352357
55Sulfur metabolism_Homo sapiens_hsa009200.92176688
56Folate biosynthesis_Homo sapiens_hsa007900.91503501
57Herpes simplex infection_Homo sapiens_hsa051680.90837392
58Complement and coagulation cascades_Homo sapiens_hsa046100.90773854
59Osteoclast differentiation_Homo sapiens_hsa043800.90479811
60Epstein-Barr virus infection_Homo sapiens_hsa051690.90114212
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.89074257
62Renin-angiotensin system_Homo sapiens_hsa046140.87265036
63p53 signaling pathway_Homo sapiens_hsa041150.86221044
64Apoptosis_Homo sapiens_hsa042100.85636299
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84766675
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84336220
67Primary immunodeficiency_Homo sapiens_hsa053400.83932849
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81053736
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80859505
70Arginine biosynthesis_Homo sapiens_hsa002200.80559862
71Non-homologous end-joining_Homo sapiens_hsa034500.80271328
72Hematopoietic cell lineage_Homo sapiens_hsa046400.80224873
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.79958780
74Shigellosis_Homo sapiens_hsa051310.78982608
75Graft-versus-host disease_Homo sapiens_hsa053320.78779997
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77337819
77Measles_Homo sapiens_hsa051620.76454148
78Pentose phosphate pathway_Homo sapiens_hsa000300.73671880
79Asthma_Homo sapiens_hsa053100.73595428
80Purine metabolism_Homo sapiens_hsa002300.69903774
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.67874651
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66253410
83Basal transcription factors_Homo sapiens_hsa030220.65605334
84Sphingolipid metabolism_Homo sapiens_hsa006000.65003710
85Galactose metabolism_Homo sapiens_hsa000520.64968842
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64725638
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64073594
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64052766
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63974529
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63031202
91Pyruvate metabolism_Homo sapiens_hsa006200.62279780
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.62213616
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59477011
94RNA degradation_Homo sapiens_hsa030180.58113044
95Viral carcinogenesis_Homo sapiens_hsa052030.56789689
96Hepatitis B_Homo sapiens_hsa051610.56706490
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.55491720
98Bladder cancer_Homo sapiens_hsa052190.55088952
99Influenza A_Homo sapiens_hsa051640.55032084
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54557465
101Vitamin digestion and absorption_Homo sapiens_hsa049770.54431707
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53543411
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53510385
104Rheumatoid arthritis_Homo sapiens_hsa053230.53179467
105Toxoplasmosis_Homo sapiens_hsa051450.52062679
106Malaria_Homo sapiens_hsa051440.50596355
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50514784
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50354953
109Hepatitis C_Homo sapiens_hsa051600.50129244
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49896206
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46733665
112Arachidonic acid metabolism_Homo sapiens_hsa005900.45871050
113Salmonella infection_Homo sapiens_hsa051320.45643194
114Staphylococcus aureus infection_Homo sapiens_hsa051500.44941364
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44924019
116Fatty acid metabolism_Homo sapiens_hsa012120.43716931
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43474216
118Collecting duct acid secretion_Homo sapiens_hsa049660.43394384
119Viral myocarditis_Homo sapiens_hsa054160.43034155
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40900585
121Selenocompound metabolism_Homo sapiens_hsa004500.40574584
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40379519
123Fatty acid degradation_Homo sapiens_hsa000710.39799318
124Alcoholism_Homo sapiens_hsa050340.39476982
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.38610416
126Acute myeloid leukemia_Homo sapiens_hsa052210.37796885
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35982796
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.35085653
129Glutathione metabolism_Homo sapiens_hsa004800.33401272
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33030644
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30956927
132HTLV-I infection_Homo sapiens_hsa051660.30437592
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29983846
134Thyroid cancer_Homo sapiens_hsa052160.29573861
135Metabolic pathways_Homo sapiens_hsa011000.28137110

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