ERP29P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)9.57309617
2ribosomal small subunit assembly (GO:0000028)9.21262682
3translational termination (GO:0006415)9.20394133
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.17662418
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.06653970
6cotranslational protein targeting to membrane (GO:0006613)7.96830809
7protein targeting to ER (GO:0045047)7.91108558
8establishment of protein localization to endoplasmic reticulum (GO:0072599)7.59076725
9translational elongation (GO:0006414)7.54203084
10maturation of SSU-rRNA (GO:0030490)7.48487959
11protein localization to endoplasmic reticulum (GO:0070972)7.41284569
12energy coupled proton transport, down electrochemical gradient (GO:0015985)7.40509947
13ATP synthesis coupled proton transport (GO:0015986)7.40509947
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.04193877
15cellular protein complex disassembly (GO:0043624)7.01716546
16viral life cycle (GO:0019058)6.93766423
17ribosomal small subunit biogenesis (GO:0042274)6.64901588
18translational initiation (GO:0006413)6.46859052
19protein complex disassembly (GO:0043241)5.90190221
20ribosomal large subunit biogenesis (GO:0042273)5.76483342
21macromolecular complex disassembly (GO:0032984)5.57958622
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.46618825
23protein targeting to membrane (GO:0006612)5.31246818
24respiratory electron transport chain (GO:0022904)5.24293809
25electron transport chain (GO:0022900)5.09648564
26nuclear-transcribed mRNA catabolic process (GO:0000956)5.05957232
27sequestering of actin monomers (GO:0042989)4.84919248
28mRNA catabolic process (GO:0006402)4.77571424
29translation (GO:0006412)4.68288375
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.66373142
31RNA catabolic process (GO:0006401)4.30480569
32ATP biosynthetic process (GO:0006754)4.28512242
33spliceosomal complex assembly (GO:0000245)4.10769827
34protein neddylation (GO:0045116)4.06256771
35regulation of mitochondrial translation (GO:0070129)3.98617142
36hydrogen ion transmembrane transport (GO:1902600)3.76509936
37protein complex biogenesis (GO:0070271)3.74902224
38termination of RNA polymerase III transcription (GO:0006386)3.63677704
39transcription elongation from RNA polymerase III promoter (GO:0006385)3.63677704
40spliceosomal snRNP assembly (GO:0000387)3.58707203
41purine nucleoside triphosphate biosynthetic process (GO:0009145)3.58179788
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.51150168
43establishment of protein localization to membrane (GO:0090150)3.49030234
44DNA synthesis involved in DNA repair (GO:0000731)3.44319802
45positive regulation of gastrulation (GO:2000543)3.41443368
46positive regulation of respiratory burst (GO:0060267)3.39542523
47mitochondrial respiratory chain complex I assembly (GO:0032981)3.39242890
48NADH dehydrogenase complex assembly (GO:0010257)3.39242890
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39242890
50mitochondrial respiratory chain complex assembly (GO:0033108)3.34837402
51proton transport (GO:0015992)3.29513472
52regulation of helicase activity (GO:0051095)3.27775578
53inner mitochondrial membrane organization (GO:0007007)3.25096389
54epithelial cilium movement (GO:0003351)3.22437826
55protein targeting (GO:0006605)3.22413946
56hydrogen transport (GO:0006818)3.22356785
57ribonucleoprotein complex biogenesis (GO:0022613)3.21832640
58cellular component biogenesis (GO:0044085)3.20918977
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20775681
60centriole replication (GO:0007099)3.20228602
61chaperone-mediated protein transport (GO:0072321)3.19710290
62CENP-A containing nucleosome assembly (GO:0034080)3.14015398
63negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.13568077
64establishment of integrated proviral latency (GO:0075713)3.12168847
65chromatin remodeling at centromere (GO:0031055)3.12017064
66transcription-coupled nucleotide-excision repair (GO:0006283)3.10997513
67establishment of protein localization to organelle (GO:0072594)3.09834076
68telomere maintenance via semi-conservative replication (GO:0032201)3.09307839
69ribonucleoside triphosphate biosynthetic process (GO:0009201)3.04040467
70urogenital system development (GO:0001655)3.03312608
717-methylguanosine mRNA capping (GO:0006370)3.02116312
72establishment of protein localization to mitochondrial membrane (GO:0090151)3.01406494
73aldehyde catabolic process (GO:0046185)2.97394654
74RNA capping (GO:0036260)2.95490441
757-methylguanosine RNA capping (GO:0009452)2.95490441
76purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.94576454
77purine nucleoside monophosphate biosynthetic process (GO:0009127)2.94576454
78otic vesicle formation (GO:0030916)2.93674297
79mismatch repair (GO:0006298)2.89523596
80water-soluble vitamin biosynthetic process (GO:0042364)2.85814419
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84479556
82nucleoside triphosphate biosynthetic process (GO:0009142)2.78970048
83telomere maintenance via recombination (GO:0000722)2.71333325
84protein localization to membrane (GO:0072657)2.68403680
85platelet dense granule organization (GO:0060155)2.65704965
86hematopoietic stem cell proliferation (GO:0071425)2.64813932
87establishment of viral latency (GO:0019043)2.63434017
88DNA ligation (GO:0006266)2.62333241
89nucleotide-excision repair, DNA gap filling (GO:0006297)2.60161178
90synaptonemal complex assembly (GO:0007130)2.59482541
91peptidyl-histidine modification (GO:0018202)2.58372102
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.52658141
93midbrain development (GO:0030901)2.52066767
94histone exchange (GO:0043486)2.51914929
95thalamus development (GO:0021794)2.50604279
96protein localization to organelle (GO:0033365)2.50011186
97translesion synthesis (GO:0019985)2.49202983
98regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.48784203
99regulation of mitotic spindle checkpoint (GO:1903504)2.48784203
100chromosome organization involved in meiosis (GO:0070192)2.47268794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.86539140
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.82791504
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.71414988
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.48284578
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.38047713
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.05719663
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.80624790
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.39517198
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38849052
10E2F7_22180533_ChIP-Seq_HELA_Human3.32839864
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.07682517
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99218056
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.97816007
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76594932
15ELK1_19687146_ChIP-ChIP_HELA_Human2.74942332
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.64408158
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.56854004
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41523995
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23932356
20XRN2_22483619_ChIP-Seq_HELA_Human2.22176106
21VDR_23849224_ChIP-Seq_CD4+_Human2.21660181
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19334266
23TTF2_22483619_ChIP-Seq_HELA_Human2.09609770
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00128724
25MYC_18940864_ChIP-ChIP_HL60_Human1.96616478
26EZH2_22144423_ChIP-Seq_EOC_Human1.93739883
27ELK1_22589737_ChIP-Seq_MCF10A_Human1.91684457
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90520993
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.89808393
30FOXP3_21729870_ChIP-Seq_TREG_Human1.84238206
31DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.80181490
32FUS_26573619_Chip-Seq_HEK293_Human1.73211385
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71597204
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70830275
35EWS_26573619_Chip-Seq_HEK293_Human1.64660833
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.64434006
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55138643
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53386989
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52258218
40AR_21909140_ChIP-Seq_LNCAP_Human1.51907711
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51057631
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50477344
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.49273834
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48761682
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48231930
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.44159184
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38376982
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36730544
49SOX2_16153702_ChIP-ChIP_HESCs_Human1.35716120
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.34359090
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31031475
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.29158293
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26915718
54VDR_22108803_ChIP-Seq_LS180_Human1.26587765
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.25458276
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.23729567
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23330722
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23257701
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21050530
60ZNF274_21170338_ChIP-Seq_K562_Hela1.19843787
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16570010
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.15055947
63HTT_18923047_ChIP-ChIP_STHdh_Human1.12890256
64IGF1R_20145208_ChIP-Seq_DFB_Human1.10871788
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07487412
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06368110
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05211417
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03536281
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03536281
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03536281
71GABP_19822575_ChIP-Seq_HepG2_Human0.98957049
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98613713
73EZH2_27304074_Chip-Seq_ESCs_Mouse0.96146664
74HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95897805
75THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95629588
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92115921
77PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92104185
78E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91981690
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91716659
80BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89611931
81CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88815673
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86244511
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.84699694
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83803217
85TP53_22573176_ChIP-Seq_HFKS_Human0.81776043
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81121175
87ER_23166858_ChIP-Seq_MCF-7_Human0.80546342
88CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79279877
89POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79117590
90NCOR_22424771_ChIP-Seq_293T_Human0.77635831
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77384212
92DCP1A_22483619_ChIP-Seq_HELA_Human0.77260245
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.76584812
94ERG_20517297_ChIP-Seq_VCAP_Human0.76291282
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.73479836
96AR_20517297_ChIP-Seq_VCAP_Human0.72648200
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.72335028
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.71395957
99RNF2_27304074_Chip-Seq_NSC_Mouse0.69584072
100P300_19829295_ChIP-Seq_ESCs_Human0.68458710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation8.47606214
2MP0003136_yellow_coat_color5.60876624
3MP0000566_synostosis4.37086246
4MP0010030_abnormal_orbit_morphology3.19011016
5MP0002234_abnormal_pharynx_morphology2.94642106
6MP0002938_white_spotting2.78447609
7MP0008058_abnormal_DNA_repair2.70177972
8MP0002277_abnormal_respiratory_mucosa2.46807983
9MP0001293_anophthalmia2.22171761
10MP0002736_abnormal_nociception_after2.11589682
11MP0001346_abnormal_lacrimal_gland2.06944725
12MP0003880_abnormal_central_pattern2.00371669
13MP0004142_abnormal_muscle_tone1.96419611
14MP0000537_abnormal_urethra_morphology1.90183842
15MP0006292_abnormal_olfactory_placode1.81872813
16MP0003315_abnormal_perineum_morphology1.81469383
17MP0009697_abnormal_copulation1.75671966
18MP0001968_abnormal_touch/_nociception1.69264068
19MP0005171_absent_coat_pigmentation1.61500618
20MP0002837_dystrophic_cardiac_calcinosis1.60014201
21MP0004957_abnormal_blastocyst_morpholog1.53082664
22MP0002697_abnormal_eye_size1.53014848
23MP0006072_abnormal_retinal_apoptosis1.51145931
24MP0003878_abnormal_ear_physiology1.46534575
25MP0005377_hearing/vestibular/ear_phenot1.46534575
26MP0001529_abnormal_vocalization1.46450104
27MP0004885_abnormal_endolymph1.42738376
28MP0003806_abnormal_nucleotide_metabolis1.42341128
29MP0001485_abnormal_pinna_reflex1.41499759
30MP0004145_abnormal_muscle_electrophysio1.38802273
31MP0003122_maternal_imprinting1.35732553
32MP0003646_muscle_fatigue1.35480795
33MP0000026_abnormal_inner_ear1.34429363
34MP0003938_abnormal_ear_development1.28154333
35MP0002095_abnormal_skin_pigmentation1.27390309
36MP0002102_abnormal_ear_morphology1.26125657
37MP0009053_abnormal_anal_canal1.25904203
38MP0008877_abnormal_DNA_methylation1.23483699
39MP0002928_abnormal_bile_duct1.19967073
40MP0008789_abnormal_olfactory_epithelium1.19862566
41MP0002132_abnormal_respiratory_system1.16330502
42MP0000631_abnormal_neuroendocrine_gland1.14862696
43MP0000778_abnormal_nervous_system1.14738540
44MP0010094_abnormal_chromosome_stability1.14317155
45MP0002282_abnormal_trachea_morphology1.12902732
46MP0008057_abnormal_DNA_replication1.12188918
47MP0002210_abnormal_sex_determination1.11935333
48MP0002160_abnormal_reproductive_system1.08946838
49MP0005391_vision/eye_phenotype1.06069323
50MP0003077_abnormal_cell_cycle1.01491510
51MP0008995_early_reproductive_senescence0.99076930
52MP0005084_abnormal_gallbladder_morpholo0.98697177
53MP0001286_abnormal_eye_development0.98295159
54MP0003942_abnormal_urinary_system0.98268839
55MP0005174_abnormal_tail_pigmentation0.96716792
56MP0001963_abnormal_hearing_physiology0.96128322
57MP0008875_abnormal_xenobiotic_pharmacok0.95269886
58MP0003937_abnormal_limbs/digits/tail_de0.95111827
59MP0003890_abnormal_embryonic-extraembry0.94943500
60MP0002092_abnormal_eye_morphology0.89700828
61MP0003186_abnormal_redox_activity0.87630494
62MP0002249_abnormal_larynx_morphology0.87508139
63MP0005253_abnormal_eye_physiology0.85281089
64MP0000653_abnormal_sex_gland0.81213269
65MP0000049_abnormal_middle_ear0.79191079
66MP0003567_abnormal_fetal_cardiomyocyte0.78391783
67MP0000762_abnormal_tongue_morphology0.77955646
68MP0002735_abnormal_chemical_nociception0.77156250
69MP0002109_abnormal_limb_morphology0.77091725
70MP0002233_abnormal_nose_morphology0.76840506
71MP0001905_abnormal_dopamine_level0.76145600
72MP0001145_abnormal_male_reproductive0.75910757
73MP0005671_abnormal_response_to0.75790867
74MP0005389_reproductive_system_phenotype0.74950081
75MP0003011_delayed_dark_adaptation0.73784860
76MP0001324_abnormal_eye_pigmentation0.73676485
77MP0003718_maternal_effect0.72556187
78MP0003283_abnormal_digestive_organ0.72506132
79MP0003755_abnormal_palate_morphology0.71851662
80MP0001986_abnormal_taste_sensitivity0.70662071
81MP0001929_abnormal_gametogenesis0.69529489
82MP0003121_genomic_imprinting0.69181201
83MP0008932_abnormal_embryonic_tissue0.69096619
84MP0002184_abnormal_innervation0.66327015
85MP0009250_abnormal_appendicular_skeleto0.66246194
86MP0003936_abnormal_reproductive_system0.65789747
87MP0005394_taste/olfaction_phenotype0.65011132
88MP0005499_abnormal_olfactory_system0.65011132
89MP0002653_abnormal_ependyma_morphology0.64347132
90MP0002272_abnormal_nervous_system0.63862167
91MP0005195_abnormal_posterior_eye0.63227597
92MP0005408_hypopigmentation0.61950624
93MP0001881_abnormal_mammary_gland0.61054611
94MP0000579_abnormal_nail_morphology0.60795851
95MP0003119_abnormal_digestive_system0.59398108
96MP0005646_abnormal_pituitary_gland0.59133233
97MP0009745_abnormal_behavioral_response0.58236463
98MP0001764_abnormal_homeostasis0.57106572
99MP0002752_abnormal_somatic_nervous0.56962447
100MP0005551_abnormal_eye_electrophysiolog0.56778961

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)7.25848809
2Abnormality of cells of the erythroid lineage (HP:0012130)4.92060392
3Acute necrotizing encephalopathy (HP:0006965)4.86976458
4Increased hepatocellular lipid droplets (HP:0006565)4.63605922
5Abnormal number of erythroid precursors (HP:0012131)4.47996509
6Macrocytic anemia (HP:0001972)4.45139262
7Acute encephalopathy (HP:0006846)4.41037445
8Mitochondrial inheritance (HP:0001427)4.37493134
9Congenital, generalized hypertrichosis (HP:0004540)4.08115516
10Progressive macrocephaly (HP:0004481)4.07283191
11Aplastic anemia (HP:0001915)4.07200395
12Abnormal mitochondria in muscle tissue (HP:0008316)4.06538206
13Colon cancer (HP:0003003)4.02960841
143-Methylglutaconic aciduria (HP:0003535)3.97019872
15Renal Fanconi syndrome (HP:0001994)3.82722838
16Lipid accumulation in hepatocytes (HP:0006561)3.82673165
17Partial duplication of thumb phalanx (HP:0009944)3.74427755
18Septo-optic dysplasia (HP:0100842)3.73817216
19Respiratory difficulties (HP:0002880)3.67312677
20Increased CSF lactate (HP:0002490)3.67102801
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.61619671
22Partial duplication of the phalanx of hand (HP:0009999)3.41786314
23Pallor (HP:0000980)3.37885056
24Hepatocellular necrosis (HP:0001404)3.27683552
25Cerebral edema (HP:0002181)3.20456779
26Hepatic necrosis (HP:0002605)3.19897728
27Exertional dyspnea (HP:0002875)3.10899967
28True hermaphroditism (HP:0010459)3.08699310
29Pancreatic cysts (HP:0001737)3.05355689
30Absent septum pellucidum (HP:0001331)2.91599284
31Absent thumb (HP:0009777)2.89919537
32Duplication of thumb phalanx (HP:0009942)2.84031369
33Meckel diverticulum (HP:0002245)2.77065982
34Chromsome breakage (HP:0040012)2.76919057
35Stenosis of the external auditory canal (HP:0000402)2.75236392
36Triphalangeal thumb (HP:0001199)2.72258316
37Abnormality of the ileum (HP:0001549)2.65756493
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.55327385
39Abnormality of the septum pellucidum (HP:0007375)2.53021891
40Oral leukoplakia (HP:0002745)2.50856742
41Abnormality of renal resorption (HP:0011038)2.43113812
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43095550
43Optic disc pallor (HP:0000543)2.42972931
44Increased intramyocellular lipid droplets (HP:0012240)2.41666691
45Leukodystrophy (HP:0002415)2.41075554
46Rib fusion (HP:0000902)2.36598254
47Hypoplastic pelvis (HP:0008839)2.35869258
48Pancreatic fibrosis (HP:0100732)2.31655660
49Abnormality of the parietal bone (HP:0002696)2.29248357
50Maternal diabetes (HP:0009800)2.28274462
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.25135455
52Abnormal number of incisors (HP:0011064)2.25114137
53Hyperphosphaturia (HP:0003109)2.25024079
54Pancytopenia (HP:0001876)2.24464294
55Abnormality of the diencephalon (HP:0010662)2.23009940
56Abnormality of chromosome stability (HP:0003220)2.19377403
57Respiratory failure (HP:0002878)2.17060427
58Exercise intolerance (HP:0003546)2.10070599
59Esophageal atresia (HP:0002032)2.08170907
60Cystic liver disease (HP:0006706)2.07797767
61Abnormality of the phalanges of the 2nd finger (HP:0009541)2.06347258
6211 pairs of ribs (HP:0000878)2.04983546
63Abnormality of reticulocytes (HP:0004312)2.02120472
64Molar tooth sign on MRI (HP:0002419)2.00391876
65Abnormality of midbrain morphology (HP:0002418)2.00391876
66Rectovaginal fistula (HP:0000143)1.98523268
67Rectal fistula (HP:0100590)1.98523268
68Supernumerary spleens (HP:0009799)1.98478110
69Duplicated collecting system (HP:0000081)1.98332607
70Abnormality of the preputium (HP:0100587)1.97821513
71Glycosuria (HP:0003076)1.94163214
72Abnormality of urine glucose concentration (HP:0011016)1.94163214
73Sclerocornea (HP:0000647)1.93097962
74Focal motor seizures (HP:0011153)1.89899030
75Depressed nasal ridge (HP:0000457)1.89127983
76Nasolacrimal duct obstruction (HP:0000579)1.88236356
77Woolly hair (HP:0002224)1.88056622
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87932557
79Hemivertebrae (HP:0002937)1.87664056
80Abnormality of the renal collecting system (HP:0004742)1.85767656
81Male pseudohermaphroditism (HP:0000037)1.81501551
82IgM deficiency (HP:0002850)1.80717512
83X-linked dominant inheritance (HP:0001423)1.80377976
84Limb dystonia (HP:0002451)1.77345748
85Duodenal stenosis (HP:0100867)1.77208227
86Small intestinal stenosis (HP:0012848)1.77208227
87Abnormal ciliary motility (HP:0012262)1.75767351
88Abnormal respiratory epithelium morphology (HP:0012253)1.74949174
89Abnormal respiratory motile cilium morphology (HP:0005938)1.74949174
90Increased serum lactate (HP:0002151)1.74646896
91Gastrointestinal atresia (HP:0002589)1.74600989
92Lactic acidosis (HP:0003128)1.74490482
93Broad metatarsal (HP:0001783)1.74208071
94Microvesicular hepatic steatosis (HP:0001414)1.74195162
95Increased muscle lipid content (HP:0009058)1.72702370
96Hyperglycinemia (HP:0002154)1.71465658
97Split foot (HP:0001839)1.67690578
98Lethargy (HP:0001254)1.66755655
99Anophthalmia (HP:0000528)1.66705468
100Abnormality of the duodenum (HP:0002246)1.66621881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.62325836
2EPHB24.25519833
3ZAK4.18893814
4TAF13.88843523
5VRK13.21753521
6STK163.18486352
7CDC73.02243390
8SRPK12.80254918
9BMPR1B2.51790721
10FGFR22.31260725
11PASK2.30687131
12PLK41.87788931
13TXK1.76974103
14NME11.76226266
15PLK31.70691996
16BRSK11.70629902
17DYRK31.59724785
18BUB11.51885571
19MKNK11.48298956
20CDK81.46760861
21TGFBR11.44425325
22BRSK21.42117387
23WNK31.41824757
24NUAK11.35208089
25TRIM281.30853562
26TTK1.22065279
27CCNB11.12400297
28STK391.09922702
29STK38L1.04062636
30MST41.01762190
31TNIK1.00421458
32DYRK20.99127083
33WNK40.98494224
34PBK0.97813609
35WNK10.97779034
36WEE10.96694143
37AKT30.95153875
38MELK0.93601901
39LRRK20.85108621
40NEK10.82015395
41UHMK10.78667971
42CSNK2A20.76284117
43PRKCG0.74789415
44ATR0.73451454
45INSRR0.72932047
46NEK20.72673508
47MAP3K60.72660050
48GRK70.72174306
49TNK20.70257322
50AURKB0.69743530
51FGFR10.67252181
52LATS10.65460947
53PLK10.63938121
54CSNK2A10.62033468
55CSNK1E0.61271686
56DYRK1A0.60694780
57CDK190.60257139
58FLT30.58729399
59MKNK20.57503263
60PINK10.56836000
61CHEK20.56117996
62EPHA40.55480487
63BCKDK0.51515227
64GRK10.50675838
65CSK0.47440435
66OBSCN0.47223657
67ERBB20.46360227
68CAMK10.45323187
69STK40.45030969
70GRK50.43946892
71KSR10.43053357
72DMPK0.43026680
73PAK20.40427797
74PRKG10.40019529
75NLK0.39590339
76NME20.39488942
77FRK0.38489433
78MAPKAPK50.37455364
79DAPK30.36242288
80ADRBK10.36125047
81CSNK1A10.35177189
82MAP3K100.35056612
83KDR0.34834758
84TIE10.32766060
85PRKACA0.32225315
86PHKG10.29886383
87PHKG20.29886383
88MAP3K40.28069210
89AURKA0.28064818
90PAK30.27154675
91PRKCQ0.27048696
92MUSK0.26829939
93DYRK1B0.26597784
94ATM0.26401159
95PRKACB0.23521821
96PRKCE0.22358601
97TAOK30.21176950
98CHEK10.20716213
99CAMK2A0.20592934
100CDK70.19610026

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.02320111
2Oxidative phosphorylation_Homo sapiens_hsa001905.03935792
3Parkinsons disease_Homo sapiens_hsa050124.12991037
4Proteasome_Homo sapiens_hsa030503.14360286
5RNA polymerase_Homo sapiens_hsa030203.13610427
6Huntingtons disease_Homo sapiens_hsa050163.12948922
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.11442864
8Mismatch repair_Homo sapiens_hsa034303.09552242
9Alzheimers disease_Homo sapiens_hsa050102.77616844
10Homologous recombination_Homo sapiens_hsa034402.65074120
11Protein export_Homo sapiens_hsa030602.59811123
12DNA replication_Homo sapiens_hsa030302.58090640
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.40074812
14Cardiac muscle contraction_Homo sapiens_hsa042602.32373023
15Fanconi anemia pathway_Homo sapiens_hsa034601.95864038
16Nucleotide excision repair_Homo sapiens_hsa034201.89709380
17Spliceosome_Homo sapiens_hsa030401.89136169
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86266457
19Butanoate metabolism_Homo sapiens_hsa006501.50441507
20Basal transcription factors_Homo sapiens_hsa030221.43689819
21Folate biosynthesis_Homo sapiens_hsa007901.34061840
22RNA transport_Homo sapiens_hsa030131.28785143
23RNA degradation_Homo sapiens_hsa030181.26150148
24One carbon pool by folate_Homo sapiens_hsa006701.17237619
25Base excision repair_Homo sapiens_hsa034101.16514232
26Fatty acid elongation_Homo sapiens_hsa000621.14143950
27Pyrimidine metabolism_Homo sapiens_hsa002401.06886542
28Basal cell carcinoma_Homo sapiens_hsa052171.00071049
29Tryptophan metabolism_Homo sapiens_hsa003800.88412066
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86229813
31Purine metabolism_Homo sapiens_hsa002300.86154258
32Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85382184
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81658293
34Caffeine metabolism_Homo sapiens_hsa002320.81586992
35Maturity onset diabetes of the young_Homo sapiens_hsa049500.76025879
36Glutathione metabolism_Homo sapiens_hsa004800.70442924
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68807862
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65234013
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64867875
40Metabolic pathways_Homo sapiens_hsa011000.63713912
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62124213
42Cell cycle_Homo sapiens_hsa041100.61827783
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61106781
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56466422
45Propanoate metabolism_Homo sapiens_hsa006400.54895756
46Nitrogen metabolism_Homo sapiens_hsa009100.54768657
47Collecting duct acid secretion_Homo sapiens_hsa049660.53990727
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50693217
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49897858
50Chemical carcinogenesis_Homo sapiens_hsa052040.49486738
51Non-homologous end-joining_Homo sapiens_hsa034500.47520613
52Fatty acid degradation_Homo sapiens_hsa000710.46765032
53Systemic lupus erythematosus_Homo sapiens_hsa053220.45363362
54Peroxisome_Homo sapiens_hsa041460.45333465
55Hedgehog signaling pathway_Homo sapiens_hsa043400.44930860
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.44362309
57Fatty acid metabolism_Homo sapiens_hsa012120.44197258
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41978811
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40762613
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.39971269
61beta-Alanine metabolism_Homo sapiens_hsa004100.39345230
62Vitamin digestion and absorption_Homo sapiens_hsa049770.38286036
63Linoleic acid metabolism_Homo sapiens_hsa005910.37641796
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36443177
65Sulfur relay system_Homo sapiens_hsa041220.35493349
66mRNA surveillance pathway_Homo sapiens_hsa030150.34114348
67Nicotine addiction_Homo sapiens_hsa050330.31796631
68Retinol metabolism_Homo sapiens_hsa008300.30216916
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28904478
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28330054
71Alcoholism_Homo sapiens_hsa050340.28049252
72Pyruvate metabolism_Homo sapiens_hsa006200.28006404
73Oocyte meiosis_Homo sapiens_hsa041140.27662110
74Cocaine addiction_Homo sapiens_hsa050300.24822201
75Sulfur metabolism_Homo sapiens_hsa009200.24361102
76Autoimmune thyroid disease_Homo sapiens_hsa053200.22430156
77Asthma_Homo sapiens_hsa053100.22100525
78Ovarian steroidogenesis_Homo sapiens_hsa049130.21669489
79N-Glycan biosynthesis_Homo sapiens_hsa005100.20680881
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19829453
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.19416635
82Phototransduction_Homo sapiens_hsa047440.19370212
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19115504
84Amphetamine addiction_Homo sapiens_hsa050310.18968866
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.17815857
86Arginine and proline metabolism_Homo sapiens_hsa003300.16815250
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.16788335
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15543254
89Olfactory transduction_Homo sapiens_hsa047400.15084980
90Synaptic vesicle cycle_Homo sapiens_hsa047210.13749974
91Rheumatoid arthritis_Homo sapiens_hsa053230.13303390
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.13184375
93Tyrosine metabolism_Homo sapiens_hsa003500.12999335
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.12408831
95Phenylalanine metabolism_Homo sapiens_hsa003600.12291770
96Epstein-Barr virus infection_Homo sapiens_hsa051690.11935500
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.10883479
98Mineral absorption_Homo sapiens_hsa049780.10084226
99Hippo signaling pathway_Homo sapiens_hsa043900.09973549
100Taste transduction_Homo sapiens_hsa047420.09251956

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