ERP44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.98278349
2COPI coating of Golgi vesicle (GO:0048205)6.98278349
3signal peptide processing (GO:0006465)6.05961302
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.95637046
5protein retention in ER lumen (GO:0006621)5.39960060
6COPII vesicle coating (GO:0048208)4.96044927
7L-phenylalanine catabolic process (GO:0006559)4.41953748
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.41953748
9L-phenylalanine metabolic process (GO:0006558)4.31014986
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.31014986
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.19236837
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.19236837
13antigen processing and presentation of endogenous antigen (GO:0019883)3.93333212
14activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.90470327
15positive regulation of nuclease activity (GO:0032075)3.83365177
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.79247502
17protein maturation by protein folding (GO:0022417)3.74037528
18ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.73071459
19negative regulation of interleukin-12 production (GO:0032695)3.72773087
20exocrine pancreas development (GO:0031017)3.69317586
21immunoglobulin mediated immune response (GO:0016064)3.63750371
22aromatic amino acid family catabolic process (GO:0009074)3.63694347
23regulation of nuclease activity (GO:0032069)3.59965288
24intestinal cholesterol absorption (GO:0030299)3.59257856
25endoplasmic reticulum unfolded protein response (GO:0030968)3.58241494
26cysteine metabolic process (GO:0006534)3.55640257
27sequestering of metal ion (GO:0051238)3.53803095
284-hydroxyproline metabolic process (GO:0019471)3.53540754
29cellular response to unfolded protein (GO:0034620)3.47866993
30protein carboxylation (GO:0018214)3.44706641
31peptidyl-glutamic acid carboxylation (GO:0017187)3.44706641
32sulfur amino acid catabolic process (GO:0000098)3.39922064
33neutrophil activation involved in immune response (GO:0002283)3.38627078
34protein N-linked glycosylation via asparagine (GO:0018279)3.36389003
35cellular response to topologically incorrect protein (GO:0035967)3.34894954
36valine metabolic process (GO:0006573)3.34359224
37peptidyl-asparagine modification (GO:0018196)3.33219328
38UDP-N-acetylglucosamine metabolic process (GO:0006047)3.30049345
39ER-nucleus signaling pathway (GO:0006984)3.29499885
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.25971619
41tryptophan metabolic process (GO:0006568)3.22292444
42triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.17317268
43homocysteine metabolic process (GO:0050667)3.16005054
44B cell mediated immunity (GO:0019724)3.08965660
45protein N-linked glycosylation (GO:0006487)3.08437904
46interferon-gamma-mediated signaling pathway (GO:0060333)3.08126671
47negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.06727075
48tryptophan catabolic process (GO:0006569)3.05269001
49indole-containing compound catabolic process (GO:0042436)3.05269001
50indolalkylamine catabolic process (GO:0046218)3.05269001
51glyoxylate metabolic process (GO:0046487)3.03506551
52aldehyde catabolic process (GO:0046185)3.01852914
53vesicle coating (GO:0006901)3.01057267
54positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.99603823
55positive regulation of gamma-delta T cell activation (GO:0046645)2.97810412
56ER to Golgi vesicle-mediated transport (GO:0006888)2.95336636
57response to peptidoglycan (GO:0032494)2.94844599
58regulation of cytokine secretion involved in immune response (GO:0002739)2.93093405
59* response to endoplasmic reticulum stress (GO:0034976)2.92721409
60eosinophil chemotaxis (GO:0048245)2.92073358
61kynurenine metabolic process (GO:0070189)2.89758695
62regulation of inflammatory response to antigenic stimulus (GO:0002861)2.89568218
63serine family amino acid biosynthetic process (GO:0009070)2.89175981
64antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.87476391
65complement activation, classical pathway (GO:0006958)2.86171900
66regulation of B cell receptor signaling pathway (GO:0050855)2.85296310
67lysine catabolic process (GO:0006554)2.85059175
68lysine metabolic process (GO:0006553)2.85059175
69cellular response to type I interferon (GO:0071357)2.84933332
70type I interferon signaling pathway (GO:0060337)2.84933332
71high-density lipoprotein particle remodeling (GO:0034375)2.82714308
72GDP-mannose metabolic process (GO:0019673)2.82154513
73DNA deamination (GO:0045006)2.80866010
74cytidine metabolic process (GO:0046087)2.80377528
75cytidine catabolic process (GO:0006216)2.80377528
76cytidine deamination (GO:0009972)2.80377528
77aromatic amino acid family metabolic process (GO:0009072)2.80310774
78positive regulation of monocyte chemotaxis (GO:0090026)2.79672467
79peptide catabolic process (GO:0043171)2.79449880
80negative regulation of fibrinolysis (GO:0051918)2.78286292
81regulation of hypersensitivity (GO:0002883)2.77933223
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77893204
83proline biosynthetic process (GO:0006561)2.77156784
84response to type I interferon (GO:0034340)2.75691852
85response to interferon-beta (GO:0035456)2.75466749
86bile acid biosynthetic process (GO:0006699)2.75064883
87regulation of interleukin-1 beta secretion (GO:0050706)2.73607802
88antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.73481162
89tyrosine metabolic process (GO:0006570)2.71404328
90intestinal absorption (GO:0050892)2.70984988
91positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.70693474
92folic acid-containing compound biosynthetic process (GO:0009396)2.70614796
93complement activation, alternative pathway (GO:0006957)2.70557623
94positive regulation of interleukin-1 beta secretion (GO:0050718)2.68526591
95regulation of protein activation cascade (GO:2000257)2.67288839
96pteridine-containing compound biosynthetic process (GO:0042559)2.66376963
97regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.66103549
98eosinophil migration (GO:0072677)2.65463235
99urea cycle (GO:0000050)2.64371115
100urea metabolic process (GO:0019627)2.64371115
101endocrine pancreas development (GO:0031018)2.64224755
102* response to unfolded protein (GO:0006986)2.64092794
103negative regulation of growth of symbiont in host (GO:0044130)2.63392092
104negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.63392092
105modulation of growth of symbiont involved in interaction with host (GO:0044144)2.63392092
106regulation of growth of symbiont in host (GO:0044126)2.63392092
107complement activation (GO:0006956)2.61471147
108alpha-linolenic acid metabolic process (GO:0036109)2.61334359
109fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.61325133
110regulation of T-helper 1 cell differentiation (GO:0045625)2.59920464
111protein autoprocessing (GO:0016540)2.59887903
112negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.59838582
113negative regulation of cell killing (GO:0031342)2.59838582
114cellular modified amino acid catabolic process (GO:0042219)2.59159871
115glycine metabolic process (GO:0006544)2.58951470
116* response to topologically incorrect protein (GO:0035966)2.58766440
117myeloid dendritic cell differentiation (GO:0043011)2.58433523
118neutrophil mediated immunity (GO:0002446)2.58259242
119reverse cholesterol transport (GO:0043691)2.57541852
120serine family amino acid metabolic process (GO:0009069)2.57140368
121myeloid dendritic cell activation (GO:0001773)2.56893148
122positive regulation of lymphocyte migration (GO:2000403)2.56397355
123cellular response to interferon-gamma (GO:0071346)2.56357129
124response to interferon-gamma (GO:0034341)2.56282607
125disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.55446938
126killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.55446938
127positive regulation of interleukin-1 secretion (GO:0050716)2.55382540
128regulation of complement activation (GO:0030449)2.55206915
129regulation of fibrinolysis (GO:0051917)2.55039048
130protein-lipid complex remodeling (GO:0034368)2.54881612
131macromolecular complex remodeling (GO:0034367)2.54881612
132plasma lipoprotein particle remodeling (GO:0034369)2.54881612
133regulation of mononuclear cell migration (GO:0071675)2.54825237
134positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.53442496
135regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.53082420
136positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.53007005
137positive regulation of B cell differentiation (GO:0045579)2.52951001
138mitochondrial calcium ion transport (GO:0006851)2.52549145
139peptide hormone processing (GO:0016486)2.51502623
140regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.50776087
141nucleotide-sugar biosynthetic process (GO:0009226)2.50681508
142tricarboxylic acid metabolic process (GO:0072350)2.49531398
143regulation of lymphocyte chemotaxis (GO:1901623)2.49082274
144regulation of interleukin-1 secretion (GO:0050704)2.47049220
145positive regulation of immunoglobulin mediated immune response (GO:0002891)2.47008385
146positive regulation of B cell mediated immunity (GO:0002714)2.47008385
147indolalkylamine metabolic process (GO:0006586)2.46303000
148nitrogen cycle metabolic process (GO:0071941)2.46055711
149regulation of interferon-alpha production (GO:0032647)2.45577718
150negative regulation of cytokine production involved in immune response (GO:0002719)2.45569817
151nucleotide transmembrane transport (GO:1901679)2.45196546
152positive regulation of T cell mediated cytotoxicity (GO:0001916)2.45086975
153tetrahydrofolate metabolic process (GO:0046653)2.44504647
154granulocyte activation (GO:0036230)2.44394232
155pyrimidine ribonucleoside catabolic process (GO:0046133)2.44332190
156benzene-containing compound metabolic process (GO:0042537)2.43660403
157lipopolysaccharide-mediated signaling pathway (GO:0031663)2.43597396
158Arp2/3 complex-mediated actin nucleation (GO:0034314)2.43324445
159branched-chain amino acid metabolic process (GO:0009081)2.42555905
160* cell redox homeostasis (GO:0045454)2.41792846
161regulation of chronic inflammatory response (GO:0002676)2.40416850
162regulation of triglyceride catabolic process (GO:0010896)2.39770522
163positive regulation of interleukin-10 production (GO:0032733)2.39704945
164T cell migration (GO:0072678)2.38025266
165regulation of T cell tolerance induction (GO:0002664)2.37925885
166proteasome assembly (GO:0043248)2.37480217
167regulation of interleukin-8 biosynthetic process (GO:0045414)2.36677931
168neutrophil activation (GO:0042119)2.35759528
169regulation of T cell mediated cytotoxicity (GO:0001914)2.34451667
170angiotensin maturation (GO:0002003)2.34351221
171oligosaccharide catabolic process (GO:0009313)2.34133623
172glycosphingolipid catabolic process (GO:0046479)2.33342057
173regulation of vitamin D biosynthetic process (GO:0060556)2.32913960
174glycolipid catabolic process (GO:0019377)2.32778291
175detection of other organism (GO:0098543)2.31270011
176actin nucleation (GO:0045010)2.29473697
177regulation of interleukin-12 production (GO:0032655)2.29435825
178myeloid leukocyte mediated immunity (GO:0002444)2.28868103
179production of molecular mediator involved in inflammatory response (GO:0002532)2.28546093
180regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.28277719
181regulation of lymphocyte migration (GO:2000401)2.27869315
182regulation of vitamin metabolic process (GO:0030656)2.27674250
183regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.27517645
184regulation of antigen processing and presentation (GO:0002577)2.27467040
185positive regulation of interleukin-8 secretion (GO:2000484)2.26550439
186positive regulation of interferon-alpha production (GO:0032727)2.24914453
187antigen processing and presentation via MHC class Ib (GO:0002475)2.24700188
188dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.24557901
189detection of bacterium (GO:0016045)2.24469500
190lymphocyte chemotaxis (GO:0048247)2.24335043
191negative regulation of viral genome replication (GO:0045071)2.24324240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.35404124
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.89728022
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.74332494
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.56034608
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.44918060
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.18113780
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.15223931
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.90646737
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.69925694
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.52169932
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51536541
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.49429947
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46407773
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.39643491
15GATA1_22025678_ChIP-Seq_K562_Human2.35593362
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35523957
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32654045
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21896910
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.11894677
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.08673252
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05448653
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.03759858
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.01254299
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.99161299
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98531202
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90913667
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86372307
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86289349
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83818005
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81885080
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77593816
32CLOCK_20551151_ChIP-Seq_293T_Human1.76363808
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.72822766
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.62687427
35GATA3_26560356_Chip-Seq_TH2_Human1.61723110
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.61641863
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58853535
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58809717
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55881663
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53991037
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53951338
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.52581343
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52557940
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50924604
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47908569
46* DCP1A_22483619_ChIP-Seq_HELA_Human1.43602177
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.41096714
48VDR_23849224_ChIP-Seq_CD4+_Human1.39095293
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38223544
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35137653
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.33752742
52GATA3_27048872_Chip-Seq_THYMUS_Human1.33549565
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32900925
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32241638
55GABP_19822575_ChIP-Seq_HepG2_Human1.31495600
56TFEB_21752829_ChIP-Seq_HELA_Human1.30734034
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30598858
58SPI1_23547873_ChIP-Seq_NB4_Human1.29917325
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29446794
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27919967
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27881647
62ELK1_19687146_ChIP-ChIP_HELA_Human1.24706544
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24399279
64E2F7_22180533_ChIP-Seq_HELA_Human1.24379842
65IRF8_27001747_Chip-Seq_BMDM_Mouse1.23747814
66VDR_24787735_ChIP-Seq_THP-1_Human1.23551105
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.22215832
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21196956
69FOXP3_21729870_ChIP-Seq_TREG_Human1.20522662
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19612822
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18950237
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18107574
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16012893
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15807007
75SPI1_23127762_ChIP-Seq_K562_Human1.15804833
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15514068
77MYC_22102868_ChIP-Seq_BL_Human1.15435114
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15197993
79SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14728126
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13570243
81NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12407649
82MYB_26560356_Chip-Seq_TH2_Human1.09700828
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06765722
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06244041
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05871674
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05389306
87GATA4_25053715_ChIP-Seq_YYC3_Human1.05060734
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04086117
89RUNX_20019798_ChIP-Seq_JUKART_Human1.03652039
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03033567
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02630980
92POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01950936
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01185681
94MYB_26560356_Chip-Seq_TH1_Human1.00305689
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99882282
96* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99862908
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99329843
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99158614
99MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97695739
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96235645
101EZH2_27294783_Chip-Seq_NPCs_Mouse0.95417206
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94904738
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94185284
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94104823
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93889669
106SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93834997
107AR_21909140_ChIP-Seq_LNCAP_Human0.93200376
108ELK1_22589737_ChIP-Seq_MCF10A_Human0.92890651
109CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91754160
110TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91458527
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91442954
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91315474
113KDM5A_27292631_Chip-Seq_BREAST_Human0.91040778
114* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90714980
115NFE2_27457419_Chip-Seq_LIVER_Mouse0.90654441
116PU_27001747_Chip-Seq_BMDM_Mouse0.89586298
117SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89298929
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89040312
119TP63_17297297_ChIP-ChIP_HaCaT_Human0.88930933
120TRIM28_21343339_ChIP-Seq_HEK293_Human0.88561529
121AR_20517297_ChIP-Seq_VCAP_Human0.88523549
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87724768
123NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86160531
124CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85695144
125SALL4_22934838_ChIP-ChIP_CD34+_Human0.85234609
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85060173
127ELF5_23300383_ChIP-Seq_T47D_Human0.84932597
128VDR_24763502_ChIP-Seq_THP-1_Human0.84694975
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84679468
130SOX2_20726797_ChIP-Seq_SW620_Human0.83997792
131FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83205735
132CRX_20693478_ChIP-Seq_RETINA_Mouse0.81199989
133GATA2_21666600_ChIP-Seq_HMVEC_Human0.80842088
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79811450
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79567732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.42174307
2MP0005360_urolithiasis3.77020203
3MP0005365_abnormal_bile_salt3.63687069
4MP0005085_abnormal_gallbladder_physiolo2.93126339
5MP0003195_calcinosis2.64228552
6MP0003806_abnormal_nucleotide_metabolis2.57436253
7MP0001666_abnormal_nutrient_absorption2.57271813
8MP0005220_abnormal_exocrine_pancreas2.40216633
9MP0005083_abnormal_biliary_tract2.32600306
10MP0008875_abnormal_xenobiotic_pharmacok2.25594029
11MP0003252_abnormal_bile_duct2.21225359
12MP0006054_spinal_hemorrhage2.14827295
13MP0008438_abnormal_cutaneous_collagen2.08757838
14MP0009840_abnormal_foam_cell2.04354796
15MP0002138_abnormal_hepatobiliary_system1.96091395
16MP0001835_abnormal_antigen_presentation1.85116808
17MP0010329_abnormal_lipoprotein_level1.79976469
18MP0003436_decreased_susceptibility_to1.78245121
19MP0003300_gastrointestinal_ulcer1.76552934
20MP0005058_abnormal_lysosome_morphology1.75631815
21MP0005332_abnormal_amino_acid1.68753783
22MP0003191_abnormal_cellular_cholesterol1.67766743
23MP0003186_abnormal_redox_activity1.66151612
24MP0009643_abnormal_urine_homeostasis1.65186210
25MP0002693_abnormal_pancreas_physiology1.64973784
26MP0003724_increased_susceptibility_to1.60088333
27MP0000609_abnormal_liver_physiology1.58600210
28MP0003183_abnormal_peptide_metabolism1.58465266
29MP0002006_tumorigenesis1.54493733
30MP0002877_abnormal_melanocyte_morpholog1.52666589
31MP0001944_abnormal_pancreas_morphology1.51201565
32MP0003705_abnormal_hypodermis_morpholog1.50532647
33MP0004264_abnormal_extraembryonic_tissu1.47609498
34MP0005319_abnormal_enzyme/_coenzyme1.39757597
35MP0000013_abnormal_adipose_tissue1.38404133
36MP0003868_abnormal_feces_composition1.37461104
37MP0005084_abnormal_gallbladder_morpholo1.34911705
38MP0003075_altered_response_to1.34558423
39MP0004043_abnormal_pH_regulation1.33536914
40MP0003448_altered_tumor_morphology1.33087532
41MP0002405_respiratory_system_inflammati1.28982287
42MP0000716_abnormal_immune_system1.28860574
43MP0008469_abnormal_protein_level1.26435526
44MP0005636_abnormal_mineral_homeostasis1.25543699
45MP0009785_altered_susceptibility_to1.23369634
46MP0001845_abnormal_inflammatory_respons1.22780417
47MP0001533_abnormal_skeleton_physiology1.22165045
48MP0001790_abnormal_immune_system1.21629365
49MP0005387_immune_system_phenotype1.21629365
50MP0002118_abnormal_lipid_homeostasis1.19817504
51MP0001764_abnormal_homeostasis1.19426924
52MP0002166_altered_tumor_susceptibility1.17575643
53MP0000689_abnormal_spleen_morphology1.16953095
54MP0000685_abnormal_immune_system1.16350801
55MP0002398_abnormal_bone_marrow1.15169733
56MP0005000_abnormal_immune_tolerance1.14820484
57MP0000343_altered_response_to1.14522846
58MP0002419_abnormal_innate_immunity1.14412301
59MP0000604_amyloidosis1.13884561
60MP0005025_abnormal_response_to1.13751939
61MP0004947_skin_inflammation1.13048726
62MP0005166_decreased_susceptibility_to1.12733547
63MP0005671_abnormal_response_to1.11578244
64MP0005164_abnormal_response_to1.10172381
65MP0009697_abnormal_copulation1.09857038
66MP0000598_abnormal_liver_morphology1.08476442
67MP0003656_abnormal_erythrocyte_physiolo1.08429107
68MP0001542_abnormal_bone_strength1.07846965
69MP0005275_abnormal_skin_tensile1.07399577
70MP0001800_abnormal_humoral_immune1.06982012
71MP0003045_fibrosis1.06479976
72MP0005408_hypopigmentation1.06430874
73MP0002254_reproductive_system_inflammat1.06012745
74MP0001873_stomach_inflammation1.05251452
75MP0002078_abnormal_glucose_homeostasis1.05011282
76MP0003693_abnormal_embryo_hatching1.04281864
77MP0002148_abnormal_hypersensitivity_rea1.03412615
78MP0002933_joint_inflammation1.02829688
79MP0002429_abnormal_blood_cell1.02204352
80MP0010234_abnormal_vibrissa_follicle1.01947114
81MP0001853_heart_inflammation1.00827752
82MP0009764_decreased_sensitivity_to1.00578893
83MP0005310_abnormal_salivary_gland1.00261790
84MP0002722_abnormal_immune_system0.99543909
85MP0002452_abnormal_antigen_presenting0.98834450
86MP0010386_abnormal_urinary_bladder0.98580553
87MP0008004_abnormal_stomach_pH0.98453883
88MP0005584_abnormal_enzyme/coenzyme_acti0.98092696
89MP0006082_CNS_inflammation0.97277998
90MP0002723_abnormal_immune_serum0.96517385
91MP0010155_abnormal_intestine_physiology0.96050285
92MP0001756_abnormal_urination0.95502405
93MP0010352_gastrointestinal_tract_polyps0.92400190
94MP0005464_abnormal_platelet_physiology0.92125134
95MP0005451_abnormal_body_composition0.90733541
96MP0004019_abnormal_vitamin_homeostasis0.90466808
97MP0003303_peritoneal_inflammation0.89630508
98MP0009384_cardiac_valve_regurgitation0.89214122
99MP0000858_altered_metastatic_potential0.89134866
100MP0009333_abnormal_splenocyte_physiolog0.87455846
101MP0005379_endocrine/exocrine_gland_phen0.85016713
102MP0002420_abnormal_adaptive_immunity0.85003988
103MP0009763_increased_sensitivity_to0.84947785
104MP0001819_abnormal_immune_cell0.83588168
105MP0002060_abnormal_skin_morphology0.83116778
106MP0003786_premature_aging0.82707240
107MP0003566_abnormal_cell_adhesion0.82113320
108MP0004782_abnormal_surfactant_physiolog0.82050785
109MP0002136_abnormal_kidney_physiology0.81515025
110MP0004883_abnormal_blood_vessel0.81407891
111MP0009642_abnormal_blood_homeostasis0.80577688
112MP0001545_abnormal_hematopoietic_system0.79954045
113MP0005397_hematopoietic_system_phenotyp0.79954045
114MP0003795_abnormal_bone_structure0.77605816
115MP0001765_abnormal_ion_homeostasis0.77566039
116MP0002998_abnormal_bone_remodeling0.77230374
117MP0005165_increased_susceptibility_to0.77103797
118MP0002277_abnormal_respiratory_mucosa0.76684523
119MP0006036_abnormal_mitochondrial_physio0.76585857
120MP0002876_abnormal_thyroid_physiology0.75805210
121MP0002928_abnormal_bile_duct0.75428022
122MP0003763_abnormal_thymus_physiology0.73845835
123MP0005023_abnormal_wound_healing0.72922760
124MP0001243_abnormal_dermal_layer0.72609105
125MP0003172_abnormal_lysosome_physiology0.71642429
126MP0008873_increased_physiological_sensi0.70815829
127MP0003866_abnormal_defecation0.70559834
128MP0001191_abnormal_skin_condition0.67637892
129MP0000465_gastrointestinal_hemorrhage0.66559428
130MP0005376_homeostasis/metabolism_phenot0.65938439
131MP0009765_abnormal_xenobiotic_induced0.63228831

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.76165068
2Hypoglycemic coma (HP:0001325)4.51254026
3Abnormality of the intrinsic pathway (HP:0010989)4.36899469
4Abnormality of liposaccharide metabolism (HP:0010968)4.10114615
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.10114615
6Abnormality of glycolipid metabolism (HP:0010969)4.10114615
7Abnormality of the common coagulation pathway (HP:0010990)3.77495665
8Abnormality of macrophages (HP:0004311)3.77293825
9Intrahepatic cholestasis (HP:0001406)3.73122523
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.70366705
11Stomatitis (HP:0010280)3.57454071
12Prolonged partial thromboplastin time (HP:0003645)3.51241115
13Hypobetalipoproteinemia (HP:0003563)3.50704731
14Hypoglycemic seizures (HP:0002173)3.43586198
15Xanthomatosis (HP:0000991)3.41167994
16Deep venous thrombosis (HP:0002625)3.39483853
17Vacuolated lymphocytes (HP:0001922)3.28765558
18Fat malabsorption (HP:0002630)3.22737007
19Recurrent abscess formation (HP:0002722)3.20223961
20Retrobulbar optic neuritis (HP:0100654)3.14328823
21Optic neuritis (HP:0100653)3.14328823
22Generalized aminoaciduria (HP:0002909)3.07937516
23Orchitis (HP:0100796)3.01019451
24Hypoproteinemia (HP:0003075)3.00906447
25Hyperinsulinemic hypoglycemia (HP:0000825)2.99560666
26Ketoacidosis (HP:0001993)2.94814392
27Ketosis (HP:0001946)2.89803437
28Symptomatic seizures (HP:0011145)2.87734202
29Myositis (HP:0100614)2.87266407
30T lymphocytopenia (HP:0005403)2.81782411
31Dysostosis multiplex (HP:0000943)2.78013404
32Reduced antithrombin III activity (HP:0001976)2.77000812
33Steatorrhea (HP:0002570)2.76640191
34Mucopolysacchariduria (HP:0008155)2.73696688
35Urinary glycosaminoglycan excretion (HP:0003541)2.73696688
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.71580419
37Abnormality of T cell number (HP:0011839)2.66037429
38Late onset (HP:0003584)2.60822312
39Complement deficiency (HP:0004431)2.60619578
40Chronic diarrhea (HP:0002028)2.58329553
41Recurrent gram-negative bacterial infections (HP:0005420)2.57570700
42Conjugated hyperbilirubinemia (HP:0002908)2.53371367
43Methylmalonic acidemia (HP:0002912)2.50102507
44Beaking of vertebral bodies (HP:0004568)2.45253823
45Abnormality of fatty-acid metabolism (HP:0004359)2.44270182
46Hypolipoproteinemia (HP:0010981)2.43895498
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.43843679
48Abnormal protein glycosylation (HP:0012346)2.42658666
49Abnormal glycosylation (HP:0012345)2.42658666
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42658666
51Abnormal protein N-linked glycosylation (HP:0012347)2.42658666
52Gout (HP:0001997)2.41872437
53Disinhibition (HP:0000734)2.41286277
54Pulmonary infiltrates (HP:0002113)2.38880199
55Abnormality of sulfur amino acid metabolism (HP:0004339)2.38129242
56Hyperammonemia (HP:0001987)2.36857883
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.36395707
58Abnormality of polysaccharide metabolism (HP:0011012)2.36395707
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.36395707
60Thrombocytosis (HP:0001894)2.35789083
61Abnormality of purine metabolism (HP:0004352)2.34601048
62Abnormality of the pancreatic islet cells (HP:0006476)2.34086027
63Abnormality of endocrine pancreas physiology (HP:0012093)2.34086027
64Hyperlipoproteinemia (HP:0010980)2.33780498
65Nausea (HP:0002018)2.33277722
66Vasculitis (HP:0002633)2.33005928
67Keratoconjunctivitis sicca (HP:0001097)2.32912682
683-Methylglutaconic aciduria (HP:0003535)2.32305251
69Petechiae (HP:0000967)2.30259171
70Hyperglycemia (HP:0003074)2.29624576
71Joint hemorrhage (HP:0005261)2.28221664
72Pancreatitis (HP:0001733)2.27723910
73Chronic obstructive pulmonary disease (HP:0006510)2.26703398
74Obstructive lung disease (HP:0006536)2.26703398
75Gangrene (HP:0100758)2.26510109
76Methylmalonic aciduria (HP:0012120)2.26009432
77Acute hepatic failure (HP:0006554)2.25222696
78Hyperbilirubinemia (HP:0002904)2.23145279
79Recurrent skin infections (HP:0001581)2.22804300
80Loss of speech (HP:0002371)2.22751067
81Myocardial infarction (HP:0001658)2.22580136
82Hemoptysis (HP:0002105)2.22479778
83Elevated erythrocyte sedimentation rate (HP:0003565)2.21210795
84Keratoconjunctivitis (HP:0001096)2.20702405
85Amyloidosis (HP:0011034)2.20340465
86Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.19401512
87Eczematoid dermatitis (HP:0000976)2.18759949
88Progressive neurologic deterioration (HP:0002344)2.18741334
89Urticaria (HP:0001025)2.18317830
90Gingival bleeding (HP:0000225)2.18012983
91Mutism (HP:0002300)2.17670423
92Encephalitis (HP:0002383)2.17014736
93Hyperglycinemia (HP:0002154)2.16996469
94Abnormality of nucleobase metabolism (HP:0010932)2.15216321
95Abnormality of complement system (HP:0005339)2.14654545
96Recurrent cutaneous fungal infections (HP:0011370)2.13341828
97Chronic mucocutaneous candidiasis (HP:0002728)2.13341828
98Nonimmune hydrops fetalis (HP:0001790)2.10144340
99Hyperglycinuria (HP:0003108)2.09998001
100Meningitis (HP:0001287)2.09452730
101Recurrent fungal infections (HP:0002841)2.09370287
102Mediastinal lymphadenopathy (HP:0100721)2.09203343
103Dicarboxylic aciduria (HP:0003215)2.09015291
104Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09015291
105Gastrointestinal infarctions (HP:0005244)2.08282675
106Type I transferrin isoform profile (HP:0003642)2.08250067
107Recurrent viral infections (HP:0004429)2.08039569
108Abnormality of vitamin B metabolism (HP:0004340)2.07512222
109Abnormal cartilage morphology (HP:0002763)2.07329730
110Protuberant abdomen (HP:0001538)2.07164816
111Acute necrotizing encephalopathy (HP:0006965)2.07075360
112Abnormality of methionine metabolism (HP:0010901)2.06441210
113Systemic lupus erythematosus (HP:0002725)2.06105027
114Hepatosplenomegaly (HP:0001433)2.05939000
115Hematochezia (HP:0002573)2.05364984
116Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04406197
117Abnormal delayed hypersensitivity skin test (HP:0002963)2.04252708
118Autoimmune hemolytic anemia (HP:0001890)2.03919785
119IgG deficiency (HP:0004315)2.02916996
120Thoracolumbar scoliosis (HP:0002944)2.02561824
121Premature loss of primary teeth (HP:0006323)2.02442342
122Polyneuropathy (HP:0001271)2.01990803
123Anorexia (HP:0002039)2.00400376
124Poor head control (HP:0002421)1.99786869
125Increased serum ferritin (HP:0003281)1.99323626
126Abnormality of T cells (HP:0002843)1.99241188
127Abnormal mitochondria in muscle tissue (HP:0008316)1.98728129
128Abdominal distention (HP:0003270)1.97936311
129Increased IgM level (HP:0003496)1.97712843
130Epidermoid cyst (HP:0200040)1.97342905
131Abnormality of transition element cation homeostasis (HP:0011030)1.95514937
132Joint swelling (HP:0001386)1.95370945
133Progressive macrocephaly (HP:0004481)1.95134720
134Degeneration of anterior horn cells (HP:0002398)1.94593532
135Abnormality of the anterior horn cell (HP:0006802)1.94593532
136Abnormal enzyme/coenzyme activity (HP:0012379)1.93828982
137Abnormality of T cell physiology (HP:0011840)1.92903920
138Abnormality of glycine metabolism (HP:0010895)1.92712178
139Abnormality of serine family amino acid metabolism (HP:0010894)1.92712178
140Tongue fasciculations (HP:0001308)1.92098241
141Elevated alkaline phosphatase (HP:0003155)1.90965421
142Increased CSF lactate (HP:0002490)1.90925610
143Mitochondrial inheritance (HP:0001427)1.89253857
144Insulin resistance (HP:0000855)1.88245946
145Abnormality of urine glucose concentration (HP:0011016)1.88216353
146Glycosuria (HP:0003076)1.88216353
147Skin nodule (HP:0200036)1.87808621
148Abnormality of the vitamin B12 metabolism (HP:0004341)1.87801581
149Cerebral hemorrhage (HP:0001342)1.87780238
150Mitral stenosis (HP:0001718)1.86907475
151Skin rash (HP:0000988)1.86676401
152Malnutrition (HP:0004395)1.86542952
153Abnormality of alkaline phosphatase activity (HP:0004379)1.86079689
154Proximal tubulopathy (HP:0000114)1.85694512
155Abnormal tarsal ossification (HP:0008369)1.80692755
156Metabolic acidosis (HP:0001942)1.80342399
157Menorrhagia (HP:0000132)1.79834677
158Vertebral compression fractures (HP:0002953)1.79511302
159Hypoalphalipoproteinemia (HP:0003233)1.78993610
160Glomerulonephritis (HP:0000099)1.78874104
161Abnormality of pyrimidine metabolism (HP:0004353)1.76446868
162Cervical subluxation (HP:0003308)1.74398751
163Interstitial pulmonary disease (HP:0006530)1.71947023
164Opisthotonus (HP:0002179)1.71795368
165Insulin-resistant diabetes mellitus (HP:0000831)1.70496150
166Vascular calcification (HP:0004934)1.69009285
167Lethargy (HP:0001254)1.68496775
168Multiple enchondromatosis (HP:0005701)1.67563761
169Recurrent bronchitis (HP:0002837)1.67457270
170Recurrent bacterial skin infections (HP:0005406)1.66999139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.35121963
2BCKDK3.81181460
3TAOK33.00559718
4MAP3K122.65770336
5RIPK42.65524839
6FLT32.59364715
7EIF2AK32.53367745
8IRAK32.45989924
9FRK2.37785779
10SIK32.36525496
11NME22.35963465
12BMPR22.31442208
13PASK2.21132546
14EIF2AK12.14588289
15INSRR2.12918821
16TRIM282.00653097
17TRIB31.97489953
18TBK11.80469409
19MAP4K11.79616547
20SCYL21.77109020
21PIM21.75826139
22ACVR1B1.75120302
23NEK91.70659595
24TYK21.68076536
25MAP3K31.67262957
26MST41.62924537
27GRK71.62402651
28FGFR41.60635050
29JAK31.56540165
30MAP4K21.55441528
31SIK11.55357476
32PDK21.55027881
33ZAP701.54328691
34PIK3CG1.50107390
35ERBB31.45642802
36PKN21.38044245
37BCR1.37188436
38BLK1.35009373
39MATK1.32179785
40TEC1.29475702
41KDR1.27155440
42TESK11.26888362
43MAP3K141.26785649
44RPS6KA41.26006225
45IRAK41.18778136
46EPHA31.14825287
47CDK191.11655335
48PTK61.11512058
49STK161.11350311
50BRSK21.07783336
51MAPKAPK31.07740473
52KIT1.05211402
53OXSR11.05185248
54PBK1.04447994
55BTK1.01989887
56LRRK20.98457266
57IKBKE0.98242407
58MAPK150.97733675
59LATS10.96825668
60TESK20.96486234
61NLK0.95615277
62JAK10.93687267
63STK100.93213960
64MAP2K30.92190895
65ADRBK20.89238993
66IRAK10.88077089
67TAOK20.86744713
68GRK10.86264780
69WNK30.86079842
70PAK40.82960468
71ITK0.82676098
72CSNK1G30.82309264
73HIPK20.80239981
74CSK0.74549015
75JAK20.74417237
76MAP3K20.73763176
77MAP2K20.72898160
78NUAK10.70220200
79STK240.69887317
80CSF1R0.69699250
81FGR0.69659287
82MST1R0.69555367
83CHUK0.69433771
84WNK40.68097338
85CLK10.67361721
86SYK0.67267669
87IKBKB0.66909848
88LYN0.65465529
89HCK0.64818714
90MAP3K110.63813883
91MET0.62926664
92MARK30.62612231
93BRAF0.62453075
94TRPM70.61866929
95NEK10.61594574
96CSNK1G20.61386125
97DYRK1B0.61323419
98LIMK10.59755942
99CSNK1G10.59685337
100TGFBR20.58705596
101TXK0.57873566
102ABL10.56694922
103YES10.56350194
104CSNK1A1L0.54755308
105ABL20.54038946
106MAP3K10.53136760
107PIM10.52949005
108PRKCI0.52695921
109CAMKK20.52318582
110ARAF0.52077964
111MAP3K100.51994454
112TGFBR10.49533675
113MAPK110.49105896
114EPHB10.48784491
115EIF2AK20.45703291
116RPS6KB20.45661506
117PRKCE0.44518238
118AKT30.43814134
119STK30.43103201
120MAP3K80.42578857
121LCK0.41559782
122BUB10.38347456
123FES0.38275640
124MOS0.37362727
125FER0.35610943
126EGFR0.35241262
127GRK60.35190961
128FGFR30.34050838
129MYLK0.33662719
130DYRK30.33070688
131RPS6KA50.32874542
132IGF1R0.32461754
133PTK20.31531416
134PDGFRA0.29130421
135MAP3K50.26619125
136PRKCQ0.26501347
137MAPKAPK20.25732164
138PRKCD0.24835436
139CSNK2A10.24281112

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.69086919
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.83156988
3Asthma_Homo sapiens_hsa053102.80859653
4Allograft rejection_Homo sapiens_hsa053302.80065380
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.76527499
6Sulfur metabolism_Homo sapiens_hsa009202.71950168
7Graft-versus-host disease_Homo sapiens_hsa053322.59444871
8Autoimmune thyroid disease_Homo sapiens_hsa053202.57894546
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.45259620
10Rheumatoid arthritis_Homo sapiens_hsa053232.44379173
11Folate biosynthesis_Homo sapiens_hsa007902.38392424
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28586551
13Selenocompound metabolism_Homo sapiens_hsa004502.06187370
14Tryptophan metabolism_Homo sapiens_hsa003802.03990110
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99788727
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81492141
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80697057
18N-Glycan biosynthesis_Homo sapiens_hsa005101.80050446
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76304682
20Fatty acid degradation_Homo sapiens_hsa000711.73268522
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.71555284
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68232781
23Complement and coagulation cascades_Homo sapiens_hsa046101.67068791
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64247567
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50368976
26Fat digestion and absorption_Homo sapiens_hsa049751.49242426
27Peroxisome_Homo sapiens_hsa041461.48038522
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44933113
29Histidine metabolism_Homo sapiens_hsa003401.43783648
30Caffeine metabolism_Homo sapiens_hsa002321.39934673
31Other glycan degradation_Homo sapiens_hsa005111.33742935
32Tuberculosis_Homo sapiens_hsa051521.33720536
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.33432451
34Phagosome_Homo sapiens_hsa041451.33146498
35Staphylococcus aureus infection_Homo sapiens_hsa051501.31631673
36One carbon pool by folate_Homo sapiens_hsa006701.31562501
37Oxidative phosphorylation_Homo sapiens_hsa001901.30198743
38Osteoclast differentiation_Homo sapiens_hsa043801.28697855
39Viral myocarditis_Homo sapiens_hsa054161.26293093
40Antigen processing and presentation_Homo sapiens_hsa046121.25297193
41Arginine biosynthesis_Homo sapiens_hsa002201.24596212
42Starch and sucrose metabolism_Homo sapiens_hsa005001.22885797
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22263243
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19976810
45Collecting duct acid secretion_Homo sapiens_hsa049661.19614018
46Propanoate metabolism_Homo sapiens_hsa006401.15916905
47Lysosome_Homo sapiens_hsa041421.15830056
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15277103
49Salmonella infection_Homo sapiens_hsa051321.14992803
50Sulfur relay system_Homo sapiens_hsa041221.13761461
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12469357
52Chemical carcinogenesis_Homo sapiens_hsa052041.10230674
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09861002
54Legionellosis_Homo sapiens_hsa051341.09244219
55Phenylalanine metabolism_Homo sapiens_hsa003601.08936065
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07792829
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07548221
58Proteasome_Homo sapiens_hsa030501.06954677
59Herpes simplex infection_Homo sapiens_hsa051681.02575951
60Malaria_Homo sapiens_hsa051441.00138122
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99046165
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98910336
63Renin-angiotensin system_Homo sapiens_hsa046140.98440725
64Shigellosis_Homo sapiens_hsa051310.97548400
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97200066
66Influenza A_Homo sapiens_hsa051640.96580102
67beta-Alanine metabolism_Homo sapiens_hsa004100.94344425
68Pentose phosphate pathway_Homo sapiens_hsa000300.93525305
69Nitrogen metabolism_Homo sapiens_hsa009100.93068443
70Pyruvate metabolism_Homo sapiens_hsa006200.92612257
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.90790222
72ABC transporters_Homo sapiens_hsa020100.88782697
73Vitamin digestion and absorption_Homo sapiens_hsa049770.88418925
74Carbon metabolism_Homo sapiens_hsa012000.88025886
75Galactose metabolism_Homo sapiens_hsa000520.87973987
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86781569
77Toxoplasmosis_Homo sapiens_hsa051450.86689999
78Biosynthesis of amino acids_Homo sapiens_hsa012300.85854935
79PPAR signaling pathway_Homo sapiens_hsa033200.85124938
80Fatty acid metabolism_Homo sapiens_hsa012120.84513526
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84472226
82Butanoate metabolism_Homo sapiens_hsa006500.83872471
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.83085175
84Tyrosine metabolism_Homo sapiens_hsa003500.83071157
85Arginine and proline metabolism_Homo sapiens_hsa003300.82023327
86African trypanosomiasis_Homo sapiens_hsa051430.81571344
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80033902
88Glutathione metabolism_Homo sapiens_hsa004800.78721972
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.78252953
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77433971
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76504723
92Parkinsons disease_Homo sapiens_hsa050120.75132884
93Retinol metabolism_Homo sapiens_hsa008300.72682677
94Steroid biosynthesis_Homo sapiens_hsa001000.68901596
95Vibrio cholerae infection_Homo sapiens_hsa051100.68736035
96Protein digestion and absorption_Homo sapiens_hsa049740.67459817
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.67395454
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64021373
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.62958694
100Fatty acid elongation_Homo sapiens_hsa000620.62565636
101Sphingolipid metabolism_Homo sapiens_hsa006000.61421361
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60202126
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.58551519
104Primary immunodeficiency_Homo sapiens_hsa053400.57362366
105TNF signaling pathway_Homo sapiens_hsa046680.56530982
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56106292
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54940028
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53681662
109DNA replication_Homo sapiens_hsa030300.52658174
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52500857
111Fructose and mannose metabolism_Homo sapiens_hsa000510.52192503
112Metabolic pathways_Homo sapiens_hsa011000.50832323
113Arachidonic acid metabolism_Homo sapiens_hsa005900.50508082
114Mineral absorption_Homo sapiens_hsa049780.50065718
115Leishmaniasis_Homo sapiens_hsa051400.49191237
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48550281
117Ribosome_Homo sapiens_hsa030100.48114135
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46534188
119Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46278393
120Chemokine signaling pathway_Homo sapiens_hsa040620.45539824
121Epstein-Barr virus infection_Homo sapiens_hsa051690.44863820
122Regulation of autophagy_Homo sapiens_hsa041400.44389720
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43918763
124Glycerolipid metabolism_Homo sapiens_hsa005610.41740180
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40866967
126T cell receptor signaling pathway_Homo sapiens_hsa046600.39721668
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.39232611
128Pyrimidine metabolism_Homo sapiens_hsa002400.39211978
129RNA degradation_Homo sapiens_hsa030180.38654002
130Pancreatic secretion_Homo sapiens_hsa049720.38464923
131Type I diabetes mellitus_Homo sapiens_hsa049400.35806737
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35659763
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35264329
134Pertussis_Homo sapiens_hsa051330.35111870
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34421928
136Insulin resistance_Homo sapiens_hsa049310.32920447
137Linoleic acid metabolism_Homo sapiens_hsa005910.32320716
138Measles_Homo sapiens_hsa051620.31674015
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30797376
140Hematopoietic cell lineage_Homo sapiens_hsa046400.30551898
141Bile secretion_Homo sapiens_hsa049760.30003059

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