ERVV-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. This envelope glycoprotein gene appears to have been selectively preserved. The gene's protein product is expressed in the placenta and acts as a syncytin in Old World monkeys, but has lost the fusogenic activity in humans and other primate lineages. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thyroid hormone generation (GO:0006590)9.82200202
2thyroid hormone metabolic process (GO:0042403)7.77883511
3estrogen biosynthetic process (GO:0006703)7.32911101
4positive regulation of hair follicle development (GO:0051798)7.21922838
5positive regulation of hair cycle (GO:0042635)7.21922838
6endothelial cell proliferation (GO:0001935)7.17980879
7negative regulation of organ growth (GO:0046621)6.49173877
8negative regulation of blood vessel endothelial cell migration (GO:0043537)6.07807304
9sprouting angiogenesis (GO:0002040)5.77308350
10thyroid gland development (GO:0030878)5.65997702
11cranial suture morphogenesis (GO:0060363)5.60499994
12tooth mineralization (GO:0034505)5.47191562
13phosphate ion transport (GO:0006817)5.38874869
14bundle of His cell to Purkinje myocyte communication (GO:0086069)5.38031739
15response to parathyroid hormone (GO:0071107)5.37746146
16blood vessel maturation (GO:0001955)5.34248087
17vascular endothelial growth factor receptor signaling pathway (GO:0048010)5.31981330
18histone H2A acetylation (GO:0043968)5.22624653
19urate metabolic process (GO:0046415)5.20687486
20peptidyl-tyrosine autophosphorylation (GO:0038083)5.08541022
21positive regulation of blood vessel endothelial cell migration (GO:0043536)4.82582038
22regulation of hair follicle development (GO:0051797)4.75898130
23trabecula formation (GO:0060343)4.73227086
24outflow tract septum morphogenesis (GO:0003148)4.60486312
25cytoskeletal anchoring at plasma membrane (GO:0007016)4.58196037
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.51489080
27DNA replication initiation (GO:0006270)4.42794380
28regulation of RNA export from nucleus (GO:0046831)4.36399874
29L-alpha-amino acid transmembrane transport (GO:1902475)4.32043237
30protein retention in ER lumen (GO:0006621)4.30213605
31regulation of G0 to G1 transition (GO:0070316)4.25765200
32peptide hormone processing (GO:0016486)4.18708226
33epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.17930302
34regulation of hippo signaling (GO:0035330)4.17585605
35syncytium formation (GO:0006949)4.16527430
36phosphate ion transmembrane transport (GO:0035435)4.13474916
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.10754167
38wound healing, spreading of epidermal cells (GO:0035313)4.06871352
39desmosome organization (GO:0002934)4.05357659
40female pregnancy (GO:0007565)4.04485367
41mating behavior (GO:0007617)4.00634315
42response to insecticide (GO:0017085)3.89271516
43negative regulation of endothelial cell migration (GO:0010596)3.82588665
44COPI coating of Golgi vesicle (GO:0048205)3.82314676
45Golgi transport vesicle coating (GO:0048200)3.82314676
46craniofacial suture morphogenesis (GO:0097094)3.80287286
47vitamin transmembrane transport (GO:0035461)3.65446190
48regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.63869806
49negative regulation of epidermal cell differentiation (GO:0045605)3.63103448
50heme transport (GO:0015886)3.56389873
51branching involved in labyrinthine layer morphogenesis (GO:0060670)3.51168955
52regulation of hair cycle (GO:0042634)3.45567410
53response to follicle-stimulating hormone (GO:0032354)3.39591008
54positive regulation of meiotic cell cycle (GO:0051446)3.38877046
55positive regulation of epidermis development (GO:0045684)3.38393955
56response to water (GO:0009415)3.38367670
57positive regulation of action potential (GO:0045760)3.36601677
58regulation of nucleobase-containing compound transport (GO:0032239)3.34240931
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.31247740
60ER overload response (GO:0006983)3.30545084
61negative regulation of activin receptor signaling pathway (GO:0032926)3.30385993
62branching involved in salivary gland morphogenesis (GO:0060445)3.28667037
63androgen biosynthetic process (GO:0006702)3.24196023
64histone H4-K12 acetylation (GO:0043983)3.21502312
65surfactant homeostasis (GO:0043129)3.17134189
66response to vitamin A (GO:0033189)3.13348902
67C21-steroid hormone biosynthetic process (GO:0006700)3.12901560
68wound healing, spreading of cells (GO:0044319)3.01472262
69prostate gland growth (GO:0060736)2.94022386
70multi-multicellular organism process (GO:0044706)2.92505774
71estrogen metabolic process (GO:0008210)2.90011903
72serine family amino acid catabolic process (GO:0009071)2.89859290
73cell surface receptor signaling pathway involved in heart development (GO:0061311)2.88297225
74keratinocyte development (GO:0003334)2.88009674
75intestinal epithelial cell development (GO:0060576)2.87570286
76osteoblast development (GO:0002076)2.84296602
77organ regeneration (GO:0031100)2.83881499
78cellular zinc ion homeostasis (GO:0006882)2.83205273
79polarized epithelial cell differentiation (GO:0030859)2.81630110
80branching involved in mammary gland duct morphogenesis (GO:0060444)2.80472185
81anatomical structure maturation (GO:0071695)2.79181784
82hyperosmotic salinity response (GO:0042538)2.79168081
83negative regulation of epidermis development (GO:0045683)2.78343503
84sequestering of metal ion (GO:0051238)2.78311591
85branching involved in ureteric bud morphogenesis (GO:0001658)2.78133411
86tachykinin receptor signaling pathway (GO:0007217)2.77127985
87nuclear pore complex assembly (GO:0051292)2.72143939
88pentose metabolic process (GO:0019321)2.71537344
89protein maturation by protein folding (GO:0022417)2.69232696
90placenta development (GO:0001890)2.68549852
91negative regulation of epithelial cell migration (GO:0010633)2.68034181
92positive regulation of systemic arterial blood pressure (GO:0003084)2.67628852
93chondrocyte development (GO:0002063)2.67345510
94positive regulation of uterine smooth muscle contraction (GO:0070474)2.66659158
95multi-organism reproductive process (GO:0044703)2.64001522
96sensory perception of taste (GO:0050909)2.63749979
97pre-miRNA processing (GO:0031054)2.63509073
98bone trabecula formation (GO:0060346)12.8009246
99activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)12.7449968
100endocrine hormone secretion (GO:0060986)12.3827802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF263_19887448_ChIP-Seq_K562_Human5.73662046
2ESR1_15608294_ChIP-ChIP_MCF-7_Human3.96192855
3ESR2_21235772_ChIP-Seq_MCF-7_Human3.22672216
4SCL_19346495_ChIP-Seq_HPC-7_Human3.01978059
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.93899976
6GATA1_26923725_Chip-Seq_HPCs_Mouse2.92563263
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.77844399
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.76831226
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52250926
10ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.42215229
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.40295927
12TCF3_18692474_ChIP-Seq_MEFs_Mouse2.33344020
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.29310259
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.01088043
15GATA1_22025678_ChIP-Seq_K562_Human10.9210165
16PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.97248442
17HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86357441
18MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86216697
19STAT3_1855785_ChIP-Seq_MESCs_Mouse1.83239076
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.82749744
21AR_21909140_ChIP-Seq_LNCAP_Human1.82630564
22SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.80701658
23AHR_22903824_ChIP-Seq_MCF-7_Human1.70975057
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.68708405
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.63295874
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61163280
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52886275
28GATA3_24758297_ChIP-Seq_MCF-7_Human1.50855513
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47597766
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42410874
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39523259
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.37180108
33CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.33072126
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31551438
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.30630232
36BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.30472233
37TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26787007
38TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25284187
39EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.21908498
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19866885
41NANOG_18692474_ChIP-Seq_MEFs_Mouse1.19798901
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13582504
43SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13361229
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09622072
45TTF2_22483619_ChIP-Seq_HELA_Human1.08473823
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.06963091
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05390983
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.04877966
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04521946
50E2F7_22180533_ChIP-Seq_HELA_Human1.03326204
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03106560
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02597112
53NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01337416
54HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01199043
55NANOG_18692474_ChIP-Seq_MESCs_Mouse1.00128809
56ERG_21242973_ChIP-ChIP_JURKAT_Human0.99498475
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97711939
58NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.97569578
59ELF5_23300383_ChIP-Seq_T47D_Human0.97043899
60OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96034770
61NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94052713
62NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93178598
63GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92291563
64MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92285724
65GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92071264
66SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91541829
67E2F1_21310950_ChIP-Seq_MCF-7_Human0.91468297
68GATA6_25053715_ChIP-Seq_YYC3_Human0.90450743
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89690198
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88118486
71E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87339929
72TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.86710010
73GATA4_25053715_ChIP-Seq_YYC3_Human0.86077789
74POU5F1_16518401_ChIP-PET_MESCs_Mouse0.85285847
75CDX2_20551321_ChIP-Seq_CACO-2_Human0.83923528
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83855191
77KLF5_25053715_ChIP-Seq_YYC3_Human0.83598871
78PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.83511033
79ARNT_22903824_ChIP-Seq_MCF-7_Human0.83205445
80MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82552666
81RACK7_27058665_Chip-Seq_MCF-7_Human0.82216325
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82010565
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81794709
84P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80202747
85SOX17_20123909_ChIP-Seq_XEN_Mouse0.80199451
86POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.79683395
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78771200
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.78427558
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.78427558
90CLOCK_20551151_ChIP-Seq_293T_Human0.77983545
91RXR_22108803_ChIP-Seq_LS180_Human0.77600755
92STAT3_18555785_ChIP-Seq_MESCs_Mouse0.77456585
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.77253879
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77240649
95PKCTHETA_26484144_Chip-Seq_BREAST_Human0.74625792
96TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.73550017
97KDM2B_26808549_Chip-Seq_K562_Human0.73188101
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.73110044
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.70712971
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.70452197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002876_abnormal_thyroid_physiology7.50676790
2MP0000003_abnormal_adipose_tissue5.63188605
3MP0002098_abnormal_vibrissa_morphology3.41479159
4MP0009672_abnormal_birth_weight3.40989772
5MP0010307_abnormal_tumor_latency3.21998621
6MP0002160_abnormal_reproductive_system3.08781259
7MP0000681_abnormal_thyroid_gland2.85136961
8MP0004782_abnormal_surfactant_physiolog2.85125342
9MP0005377_hearing/vestibular/ear_phenot2.82624284
10MP0003878_abnormal_ear_physiology2.82624284
11MP0000647_abnormal_sebaceous_gland2.78640302
12MP0005375_adipose_tissue_phenotype2.65369673
13MP0000427_abnormal_hair_cycle2.52976549
14MP0004264_abnormal_extraembryonic_tissu2.48857703
15MP0001881_abnormal_mammary_gland2.27080136
16MP0010234_abnormal_vibrissa_follicle2.26199375
17MP0005389_reproductive_system_phenotype2.23917203
18MP0009333_abnormal_splenocyte_physiolog2.20829028
19MP0002796_impaired_skin_barrier1.97967625
20MP0003941_abnormal_skin_development1.89570515
21MP0001346_abnormal_lacrimal_gland1.86756584
22MP0005023_abnormal_wound_healing1.80541108
23MP0000383_abnormal_hair_follicle1.76747887
24MP0004147_increased_porphyrin_level1.74134988
25MP0000013_abnormal_adipose_tissue1.74013222
26MP0009703_decreased_birth_body1.70630878
27MP0000377_abnormal_hair_follicle1.70396611
28MP0010678_abnormal_skin_adnexa1.65954845
29MP0000631_abnormal_neuroendocrine_gland1.63604811
30MP0002909_abnormal_adrenal_gland1.62381107
31MP0000627_abnormal_mammary_gland1.62073562
32MP0003448_altered_tumor_morphology1.60855393
33MP0009115_abnormal_fat_cell1.60233001
34MP0003693_abnormal_embryo_hatching1.57611561
35MP0005076_abnormal_cell_differentiation1.52971138
36MP0004185_abnormal_adipocyte_glucose1.48340435
37MP0002127_abnormal_cardiovascular_syste1.47377212
38MP0004858_abnormal_nervous_system1.45383634
39MP0009697_abnormal_copulation1.44291036
40MP0001545_abnormal_hematopoietic_system1.43167901
41MP0005397_hematopoietic_system_phenotyp1.43167901
42MP0004019_abnormal_vitamin_homeostasis1.41622027
43MP0010094_abnormal_chromosome_stability1.40837055
44MP0008775_abnormal_heart_ventricle1.35238840
45MP0003936_abnormal_reproductive_system1.34582377
46MP0005257_abnormal_intraocular_pressure1.30435099
47MP0005501_abnormal_skin_physiology1.26739670
48MP0001216_abnormal_epidermal_layer1.26266833
49MP0003566_abnormal_cell_adhesion1.26239015
50MP0001919_abnormal_reproductive_system1.23349878
51MP0005379_endocrine/exocrine_gland_phen1.22133872
52MP0002086_abnormal_extraembryonic_tissu1.20864743
53MP0002254_reproductive_system_inflammat1.16131168
54MP0004272_abnormal_basement_membrane1.10595676
55MP0000358_abnormal_cell_content/1.09668873
56MP0005334_abnormal_fat_pad1.07904454
57MP0001348_abnormal_lacrimal_gland1.02677876
58MP0003567_abnormal_fetal_cardiomyocyte1.02040233
59MP0004233_abnormal_muscle_weight1.01675677
60MP0001730_embryonic_growth_arrest0.98972575
61MP0000516_abnormal_urinary_system0.96339504
62MP0005367_renal/urinary_system_phenotyp0.96339504
63MP0005647_abnormal_sex_gland0.95250208
64MP0010352_gastrointestinal_tract_polyps0.92214940
65MP0004957_abnormal_blastocyst_morpholog0.91889245
66MP0003984_embryonic_growth_retardation0.91836758
67MP0000537_abnormal_urethra_morphology0.91288996
68MP0003890_abnormal_embryonic-extraembry0.90351535
69MP0002088_abnormal_embryonic_growth/wei0.89894480
70MP0005319_abnormal_enzyme/_coenzyme0.89548369
71MP0003183_abnormal_peptide_metabolism0.86578657
72MP0008004_abnormal_stomach_pH0.86246723
73MP0001672_abnormal_embryogenesis/_devel0.85242800
74MP0005380_embryogenesis_phenotype0.85242800
75MP0005408_hypopigmentation0.84731911
76MP0006035_abnormal_mitochondrial_morpho0.84365039
77MP0001697_abnormal_embryo_size0.83830903
78MP0002970_abnormal_white_adipose0.81658304
79MP0000367_abnormal_coat/_hair0.80413019
80MP0002210_abnormal_sex_determination0.79345279
81MP0006082_CNS_inflammation0.73861348
82MP0005623_abnormal_meninges_morphology0.71063424
83MP0001849_ear_inflammation0.70069226
84MP0005636_abnormal_mineral_homeostasis0.70050922
85MP0003718_maternal_effect0.69169430
86MP0001243_abnormal_dermal_layer0.68419285
87MP0001145_abnormal_male_reproductive0.68031827
88MP0000534_abnormal_ureter_morphology0.66909530
89MP0004808_abnormal_hematopoietic_stem0.65352818
90MP0006138_congestive_heart_failure0.64835551
91MP0002697_abnormal_eye_size0.64402246
92MP0002080_prenatal_lethality0.64391671
93MP0001731_abnormal_postnatal_growth0.64223740
94MP0003115_abnormal_respiratory_system0.62727042
95MP0002148_abnormal_hypersensitivity_rea0.60813656
96MP0005409_darkened_coat_color0.60021467
97MP0003453_abnormal_keratinocyte_physiol0.59507163
98MP0004085_abnormal_heartbeat0.59106152
99MP0003959_abnormal_lean_body0.55767017
100MP0002925_abnormal_cardiovascular_devel0.55162938

Predicted human phenotypes

RankGene SetZ-score
1Cervical subluxation (HP:0003308)7.68164112
2Broad metatarsal (HP:0001783)6.89566235
3Ankle contracture (HP:0006466)6.18647878
4Proximal tubulopathy (HP:0000114)5.42549165
5Generalized aminoaciduria (HP:0002909)5.15632053
6Wrist flexion contracture (HP:0001239)5.02001065
7Aplasia cutis congenita (HP:0001057)4.95087032
8Amelogenesis imperfecta (HP:0000705)4.77969849
9Right ventricular cardiomyopathy (HP:0011663)4.58719661
10Woolly hair (HP:0002224)4.55935019
11Protrusio acetabuli (HP:0003179)4.46096491
12Abnormality of the parietal bone (HP:0002696)4.34415711
13Abnormality of dental color (HP:0011073)4.29237242
14Pendular nystagmus (HP:0012043)4.10270801
15Vertebral compression fractures (HP:0002953)3.98407385
16Severe visual impairment (HP:0001141)3.84104503
17Abnormality of the frontal sinuses (HP:0002687)3.83158767
18Hyperglycinuria (HP:0003108)3.68768433
19Widely patent fontanelles and sutures (HP:0004492)3.57943306
20Fragile nails (HP:0001808)3.50621060
21Hyperglycinemia (HP:0002154)3.33556780
22Abnormality of permanent molar morphology (HP:0011071)3.28377973
23Abnormality of the dental root (HP:0006486)3.28377973
24Taurodontia (HP:0000679)3.28377973
25Neonatal death (HP:0003811)3.06697846
26Aplasia of the musculature (HP:0100854)3.06345853
27Split foot (HP:0001839)3.02102298
28Abnormality of molar morphology (HP:0011070)2.98722140
29Abnormality of molar (HP:0011077)2.98722140
30Hip contracture (HP:0003273)2.94353039
31Abnormality of the dental pulp (HP:0006479)2.88558768
32Short clavicles (HP:0000894)2.79030073
33Aplastic anemia (HP:0001915)2.74648892
34Depressed nasal tip (HP:0000437)2.72030329
35Narrow nasal bridge (HP:0000446)2.68640051
36Popliteal pterygium (HP:0009756)2.68544084
37Oligodactyly (hands) (HP:0001180)2.67340400
38Abnormal sex determination (HP:0012244)2.65464402
39Sex reversal (HP:0012245)2.65464402
40Congenital ichthyosiform erythroderma (HP:0007431)2.55152641
41Aplasia/Hypoplasia of the clavicles (HP:0006710)2.52569359
42Delayed closure of the anterior fontanelle (HP:0001476)2.49458428
43Skin nodule (HP:0200036)2.47768081
44Impulsivity (HP:0100710)2.41983946
45Hyperphosphaturia (HP:0003109)2.38650712
46Birth length less than 3rd percentile (HP:0003561)2.38503182
47Curly hair (HP:0002212)2.38091629
48Wide cranial sutures (HP:0010537)2.30130625
49Renal salt wasting (HP:0000127)2.29156876
50Abnormality of glycine metabolism (HP:0010895)2.27442766
51Abnormality of serine family amino acid metabolism (HP:0010894)2.27442766
52Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.23855015
53Sparse lateral eyebrow (HP:0005338)2.22770751
54Ventricular tachycardia (HP:0004756)2.20977656
55Amniotic constriction ring (HP:0009775)2.16174407
56Abnormality of placental membranes (HP:0011409)2.16174407
57Oligodactyly (HP:0012165)2.08843967
58Parakeratosis (HP:0001036)2.05156611
59Abnormal urine phosphate concentration (HP:0012599)2.03336013
60Osteomalacia (HP:0002749)2.00569395
61Abnormality of the acetabulum (HP:0003170)2.00340896
62Abnormality of urine glucose concentration (HP:0011016)1.97992887
63Glycosuria (HP:0003076)1.97992887
64Abolished electroretinogram (ERG) (HP:0000550)1.97821040
65Fused cervical vertebrae (HP:0002949)1.97121035
66Esophageal varix (HP:0002040)1.94972010
67Lip pit (HP:0100267)1.93839093
68Abnormality of the renal collecting system (HP:0004742)1.93600562
69Abnormality of pyrimidine metabolism (HP:0004353)1.91507329
70Abnormality of DNA repair (HP:0003254)1.88656104
71Hyperaldosteronism (HP:0000859)1.87682356
72Flat acetabular roof (HP:0003180)1.86815612
73Limited hip movement (HP:0008800)1.86284404
74Hypergonadotropic hypogonadism (HP:0000815)1.84597471
75Tarsal synostosis (HP:0008368)1.83417143
76Abnormality of cells of the erythroid lineage (HP:0012130)1.83081971
77Abnormality of the labia majora (HP:0012881)1.82980829
78Abnormal number of erythroid precursors (HP:0012131)1.81808029
79Abnormality of proline metabolism (HP:0010907)1.79883212
80Hydroxyprolinuria (HP:0003080)1.79883212
81Abnormality of the proximal phalanges of the hand (HP:0009834)1.79582537
82Reticulocytopenia (HP:0001896)1.78041009
83Delayed cranial suture closure (HP:0000270)1.75848733
84Chorioretinal atrophy (HP:0000533)1.75672449
85Abnormal auditory evoked potentials (HP:0006958)1.75642077
86Duplication of thumb phalanx (HP:0009942)1.74844207
87Aplasia involving forearm bones (HP:0009822)1.74437775
88Absent forearm bone (HP:0003953)1.74437775
89Absent eyebrow (HP:0002223)1.72575090
90Absent radius (HP:0003974)1.72406265
91Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72291896
92Decreased circulating renin level (HP:0003351)1.69194313
93Hypercalciuria (HP:0002150)1.68253972
94Septate vagina (HP:0001153)1.64085718
95Split hand (HP:0001171)1.63592124
96Bilateral sensorineural hearing impairment (HP:0008619)1.63356761
97Ectropion (HP:0000656)1.62589548
98Homocystinuria (HP:0002156)1.61863131
99Abnormality of homocysteine metabolism (HP:0010919)1.61863131
100Aplasia/Hypoplasia involving the musculature (HP:0001460)1.61734375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.24636199
2NME14.18068720
3ICK4.01267384
4PBK3.68160870
5TYRO33.64031760
6EPHA23.41714270
7LATS23.09948471
8MST42.99245020
9WEE12.90994877
10RPS6KB22.42695645
11CDK192.27191174
12EIF2AK12.26888636
13CDK122.23891761
14EIF2AK31.99321771
15LATS11.98748782
16GSK3A1.96492634
17MAP3K71.64199817
18AURKA1.40695993
19PDGFRA1.35522446
20CDK61.33880110
21CDK71.23880000
22MATK1.23333891
23NME21.23206291
24PIM11.22453309
25STK101.16918109
26PDK21.14688187
27TESK21.12244223
28LRRK21.11955170
29KDR1.11486295
30PLK31.10668008
31PRKG21.08745946
32MAP2K11.08718813
33AKT21.04303155
34SMG11.04299706
35TSSK60.95754520
36BRSK20.95235217
37TGFBR10.94614365
38STK38L0.94517946
39PAK40.93518125
40PTK20.92590920
41PLK10.91049139
42CHEK10.89267462
43TESK10.86296533
44PLK40.84026664
45BUB10.81940390
46FRK0.81673598
47CAMK1D0.81602441
48NEK60.78894497
49CHEK20.77961857
50INSRR0.76650717
51FGFR20.76403069
52FER0.75913018
53OXSR10.73646970
54RPS6KA40.69945588
55NEK10.68858451
56STK380.63238352
57RPS6KL10.61592598
58RPS6KC10.61592598
59TTK0.60925826
60AURKB0.59959501
61RPS6KA60.59606825
62RPS6KA20.58743013
63TGFBR20.56675307
64ERBB40.55308410
65PASK0.55143831
66NEK90.54149388
67SRC0.52705830
68ZAP700.51447025
69PRKCI0.50800658
70MTOR0.49558584
71PRKD20.47944035
72WNK40.47400197
73PTK2B0.47084659
74CSNK1A10.46795598
75CSNK1E0.46460939
76STK390.46407506
77MET0.46255789
78CDK10.46072731
79TXK0.45854491
80PRKCH0.45170503
81PRKAA20.43203350
82MST1R0.42027854
83PRKCD0.40678668
84CDK20.39725972
85BRAF0.38702052
86PKN10.37882463
87MAPK10.37829263
88SGK30.35777670
89BRD40.35446256
90DYRK1B0.32173646
91GSK3B0.31208448
92SCYL20.27490100
93MAPK100.27110850
94PRKACB0.26729594
95RPS6KA10.26557535
96DAPK30.25729245
97EGFR0.25695633
98JAK20.24947477
99PDGFRB0.24895640
100MARK20.24365156

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049135.21175496
2Renin-angiotensin system_Homo sapiens_hsa046143.42893647
3Thyroid hormone synthesis_Homo sapiens_hsa049182.83034010
4N-Glycan biosynthesis_Homo sapiens_hsa005102.79741692
5Steroid hormone biosynthesis_Homo sapiens_hsa001402.78398236
6p53 signaling pathway_Homo sapiens_hsa041152.65119366
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.58836715
8Autoimmune thyroid disease_Homo sapiens_hsa053202.57866874
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.55472910
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.26788481
11Prolactin signaling pathway_Homo sapiens_hsa049172.26561344
12Vitamin digestion and absorption_Homo sapiens_hsa049771.84991007
13Small cell lung cancer_Homo sapiens_hsa052221.80317102
14HIF-1 signaling pathway_Homo sapiens_hsa040661.79492424
15PI3K-Akt signaling pathway_Homo sapiens_hsa041511.73858437
16GnRH signaling pathway_Homo sapiens_hsa049121.67813702
17Selenocompound metabolism_Homo sapiens_hsa004501.63280484
18Ras signaling pathway_Homo sapiens_hsa040141.61840599
19Rap1 signaling pathway_Homo sapiens_hsa040151.57939710
20Bladder cancer_Homo sapiens_hsa052191.57938880
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53687945
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52004033
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50695486
24Cell cycle_Homo sapiens_hsa041101.50559345
25Prostate cancer_Homo sapiens_hsa052151.50093390
26Ribosome_Homo sapiens_hsa030101.44856505
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38247090
28Arginine and proline metabolism_Homo sapiens_hsa003301.29006235
29Thyroid cancer_Homo sapiens_hsa052161.25606332
30RNA transport_Homo sapiens_hsa030131.21027412
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19939527
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15752377
33Basal cell carcinoma_Homo sapiens_hsa052171.13158057
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12339710
35Pathways in cancer_Homo sapiens_hsa052001.11766831
36Hippo signaling pathway_Homo sapiens_hsa043901.11515586
37Arginine biosynthesis_Homo sapiens_hsa002201.11219392
38Mineral absorption_Homo sapiens_hsa049781.10814404
39One carbon pool by folate_Homo sapiens_hsa006701.10099880
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08904601
41Homologous recombination_Homo sapiens_hsa034401.07273339
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05205008
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01587212
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01017048
45Hedgehog signaling pathway_Homo sapiens_hsa043400.98296788
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97404706
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96951255
48Folate biosynthesis_Homo sapiens_hsa007900.95495803
49Proteasome_Homo sapiens_hsa030500.91797848
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86546051
51mRNA surveillance pathway_Homo sapiens_hsa030150.84619170
52Protein digestion and absorption_Homo sapiens_hsa049740.83682625
53Taste transduction_Homo sapiens_hsa047420.83466611
54Galactose metabolism_Homo sapiens_hsa000520.82878414
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82298438
56Oocyte meiosis_Homo sapiens_hsa041140.82167547
57Inositol phosphate metabolism_Homo sapiens_hsa005620.76802717
58Focal adhesion_Homo sapiens_hsa045100.72422205
59Starch and sucrose metabolism_Homo sapiens_hsa005000.66102427
60Sphingolipid metabolism_Homo sapiens_hsa006000.58611210
61Adherens junction_Homo sapiens_hsa045200.57754090
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55693344
63Nucleotide excision repair_Homo sapiens_hsa034200.53250923
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.52929325
65ABC transporters_Homo sapiens_hsa020100.51445639
66Antigen processing and presentation_Homo sapiens_hsa046120.51414918
67Sulfur relay system_Homo sapiens_hsa041220.50195693
68FoxO signaling pathway_Homo sapiens_hsa040680.49581424
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49341210
70Tight junction_Homo sapiens_hsa045300.49108775
71Proteoglycans in cancer_Homo sapiens_hsa052050.48261342
72Spliceosome_Homo sapiens_hsa030400.46550584
73MicroRNAs in cancer_Homo sapiens_hsa052060.45778238
74Estrogen signaling pathway_Homo sapiens_hsa049150.44939094
75Insulin signaling pathway_Homo sapiens_hsa049100.42893700
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.41765672
77Sulfur metabolism_Homo sapiens_hsa009200.40221140
78Endometrial cancer_Homo sapiens_hsa052130.39734987
79Chemical carcinogenesis_Homo sapiens_hsa052040.39637005
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38474075
81Viral carcinogenesis_Homo sapiens_hsa052030.38143645
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.37586113
83Linoleic acid metabolism_Homo sapiens_hsa005910.36904012
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36741166
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36675652
86ECM-receptor interaction_Homo sapiens_hsa045120.36554522
87Retinol metabolism_Homo sapiens_hsa008300.36350682
88Vibrio cholerae infection_Homo sapiens_hsa051100.35607603
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33775864
90Collecting duct acid secretion_Homo sapiens_hsa049660.33387534
91AMPK signaling pathway_Homo sapiens_hsa041520.33224591
92DNA replication_Homo sapiens_hsa030300.30946999
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.30491250
94Ether lipid metabolism_Homo sapiens_hsa005650.30033557
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29922441
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29904674
97Mismatch repair_Homo sapiens_hsa034300.28050575
98Fanconi anemia pathway_Homo sapiens_hsa034600.26199000
99Metabolic pathways_Homo sapiens_hsa011000.26111487
100Glutathione metabolism_Homo sapiens_hsa004800.24528237

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »