ESCO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ESCO1 belongs to a conserved family of acetyltransferases involved in sister chromatid cohesion (Hou and Zou, 2005 [PubMed 15958495]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.10510930
2monoubiquitinated protein deubiquitination (GO:0035520)4.93922863
3DNA double-strand break processing (GO:0000729)4.56663218
4metaphase plate congression (GO:0051310)4.48877665
5regulation of DNA endoreduplication (GO:0032875)4.19814624
6establishment of chromosome localization (GO:0051303)4.13589402
7regulation of centriole replication (GO:0046599)4.08742988
8meiotic chromosome segregation (GO:0045132)3.90162837
9negative regulation of translation, ncRNA-mediated (GO:0040033)3.85205283
10regulation of translation, ncRNA-mediated (GO:0045974)3.85205283
11negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.85205283
12nuclear pore complex assembly (GO:0051292)3.74405061
13regulation of nuclear cell cycle DNA replication (GO:0033262)3.72576382
14mitotic chromosome condensation (GO:0007076)3.68339967
15prenylation (GO:0097354)3.66722207
16protein prenylation (GO:0018342)3.66722207
17synapsis (GO:0007129)3.65631750
18attachment of spindle microtubules to kinetochore (GO:0008608)3.63861272
19somatic diversification of immune receptors via somatic mutation (GO:0002566)3.62284875
20somatic hypermutation of immunoglobulin genes (GO:0016446)3.62284875
21maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.54246345
22regulation of spindle organization (GO:0090224)3.52729069
23positive regulation of mitotic sister chromatid separation (GO:1901970)3.49458467
24positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49458467
25positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49458467
26regulation of centrosome duplication (GO:0010824)3.47010649
27somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.44411899
28isotype switching (GO:0045190)3.44411899
29somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.44411899
30cellular response to exogenous dsRNA (GO:0071360)3.42749022
31non-recombinational repair (GO:0000726)3.42530765
32double-strand break repair via nonhomologous end joining (GO:0006303)3.42530765
33histone mRNA catabolic process (GO:0071044)3.38298206
34mitotic G2/M transition checkpoint (GO:0044818)3.37982049
35pre-miRNA processing (GO:0031054)3.37386267
36regulation of establishment of cell polarity (GO:2000114)3.37370596
37positive regulation of gamma-delta T cell activation (GO:0046645)3.35518631
38negative regulation of DNA recombination (GO:0045910)3.35352720
39protein K11-linked deubiquitination (GO:0035871)3.33103484
40DNA replication checkpoint (GO:0000076)3.31488075
41maturation of 5.8S rRNA (GO:0000460)3.31209875
42nuclear pore organization (GO:0006999)3.30271957
43double-strand break repair via homologous recombination (GO:0000724)3.28817154
44mitotic spindle checkpoint (GO:0071174)3.28532112
45protein localization to kinetochore (GO:0034501)3.28007771
46regulation of centrosome cycle (GO:0046605)3.27969859
47recombinational repair (GO:0000725)3.27967791
48kinetochore organization (GO:0051383)3.27688697
49histone H2A monoubiquitination (GO:0035518)3.27226876
50replication fork processing (GO:0031297)3.23829929
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.23645342
52negative regulation of mitotic sister chromatid separation (GO:2000816)3.22936572
53negative regulation of sister chromatid segregation (GO:0033046)3.22936572
54negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22936572
55negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22936572
56negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22936572
57protein localization to chromosome, centromeric region (GO:0071459)3.19936181
58negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.19538622
59keratinocyte development (GO:0003334)3.15041747
60negative regulation of chromosome segregation (GO:0051985)3.14198584
61histone H2A acetylation (GO:0043968)3.13838605
62CENP-A containing nucleosome assembly (GO:0034080)3.13282162
63mitotic sister chromatid cohesion (GO:0007064)3.11355993
64positive regulation of chromosome segregation (GO:0051984)3.11025621
65kinetochore assembly (GO:0051382)3.08803522
66DNA replication-independent nucleosome organization (GO:0034724)3.08773285
67DNA replication-independent nucleosome assembly (GO:0006336)3.08773285
68resolution of meiotic recombination intermediates (GO:0000712)3.08299983
69regulation of mitotic sister chromatid separation (GO:0010965)3.08075187
70regulation of mitotic sister chromatid segregation (GO:0033047)3.08075187
71regulation of sister chromatid segregation (GO:0033045)3.08075187
72protein K6-linked ubiquitination (GO:0085020)3.06852336
73histone mRNA metabolic process (GO:0008334)3.05723797
74DNA catabolic process, exonucleolytic (GO:0000738)3.04013929
75postreplication repair (GO:0006301)3.02736381
76regulation of mitotic spindle organization (GO:0060236)3.02245522
77regulation of transcription from RNA polymerase I promoter (GO:0006356)3.02013911
78chromatin remodeling at centromere (GO:0031055)3.01027808
79telomere maintenance via telomerase (GO:0007004)3.00215890
80regulation of helicase activity (GO:0051095)2.98678446
81response to X-ray (GO:0010165)2.98503037
82regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.98387178
83DNA replication-dependent nucleosome organization (GO:0034723)2.98216641
84DNA replication-dependent nucleosome assembly (GO:0006335)2.98216641
85regulation of meiosis I (GO:0060631)2.98206029
86spindle assembly checkpoint (GO:0071173)2.98089166
87pore complex assembly (GO:0046931)2.97670935
88mitotic spindle assembly checkpoint (GO:0007094)2.97075939
89oocyte maturation (GO:0001556)2.96187354
90N-terminal protein amino acid acetylation (GO:0006474)2.95883745
91poly(A)+ mRNA export from nucleus (GO:0016973)2.94892900
92regulation of response to interferon-gamma (GO:0060330)2.94487335
93mitotic G2 DNA damage checkpoint (GO:0007095)2.94120197
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.92573557
95positive regulation of histone H3-K4 methylation (GO:0051571)2.92047111
96regulation of establishment or maintenance of cell polarity (GO:0032878)2.90706438
97histone exchange (GO:0043486)2.89533104
98regulation of MHC class II biosynthetic process (GO:0045346)2.88679756
99rRNA catabolic process (GO:0016075)2.87854315
100intra-S DNA damage checkpoint (GO:0031573)2.87759517
101somatic recombination of immunoglobulin gene segments (GO:0016447)2.85625109
102chromosome segregation (GO:0007059)2.85170156
103negative regulation of DNA-dependent DNA replication (GO:2000104)2.84635271
104regulation of histone H3-K27 methylation (GO:0061085)2.83857948
105exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83192129
106DNA damage induced protein phosphorylation (GO:0006975)2.82872991
107female gonad development (GO:0008585)2.82351453
108regulation of sister chromatid cohesion (GO:0007063)2.82240415
109ncRNA catabolic process (GO:0034661)2.81996691
110neural tube formation (GO:0001841)2.79191803
111myoblast migration (GO:0051451)2.77082918
112centrosome organization (GO:0051297)2.76308664
113double-strand break repair (GO:0006302)2.75652847
114somatic diversification of immunoglobulins (GO:0016445)2.75480876
115microtubule anchoring (GO:0034453)2.75410868
116positive regulation of protein import into nucleus, translocation (GO:0033160)2.75325276
117DNA synthesis involved in DNA repair (GO:0000731)2.75208564
118regulation of gene silencing by RNA (GO:0060966)2.73839100
119regulation of posttranscriptional gene silencing (GO:0060147)2.73839100
120regulation of gene silencing by miRNA (GO:0060964)2.73839100
121spindle checkpoint (GO:0031577)2.72989762
122mitotic nuclear envelope disassembly (GO:0007077)2.72704273
123regulation of telomere maintenance (GO:0032204)2.71598741
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71161960
125regulation of telomere maintenance via telomerase (GO:0032210)2.70175206
126hepatocyte apoptotic process (GO:0097284)2.69699197
127DNA ligation (GO:0006266)2.68940838
128* sister chromatid cohesion (GO:0007062)2.68882219
129RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.68558983
130nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.67733613
131regulation of RIG-I signaling pathway (GO:0039535)2.66661673
132regulation of retinoic acid receptor signaling pathway (GO:0048385)2.64941934
133negative regulation of meiosis (GO:0045835)2.63665680
134regulation of RNA export from nucleus (GO:0046831)2.63495062
135piRNA metabolic process (GO:0034587)2.62575757
136regulation of chromosome segregation (GO:0051983)2.61790495
137mitotic sister chromatid segregation (GO:0000070)2.61567386
138meiosis I (GO:0007127)2.59135049
139histone H3-K9 demethylation (GO:0033169)2.58845655
140regulation of mitotic metaphase/anaphase transition (GO:0030071)2.58648215
141male meiosis I (GO:0007141)2.58556977
142histone H2A ubiquitination (GO:0033522)2.57614714
143meiotic cell cycle (GO:0051321)2.57496338
144regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.57411142
145female gamete generation (GO:0007292)2.57186037
146protein localization to chromosome (GO:0034502)2.56881004
147DNA-dependent DNA replication (GO:0006261)2.53898733
148nuclear envelope disassembly (GO:0051081)2.53087909
149membrane disassembly (GO:0030397)2.53087909
150cellular response to interleukin-15 (GO:0071350)2.52884110
151regulation of B cell receptor signaling pathway (GO:0050855)2.52875391
152histone demethylation (GO:0016577)2.50865123
153regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.50591779
154regulation of mitotic spindle checkpoint (GO:1903504)2.50591779
155regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.49832233
156positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.49682235
157regulation of double-strand break repair via homologous recombination (GO:0010569)2.49473142
158interferon-gamma-mediated signaling pathway (GO:0060333)2.46975136
159DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.46891815
160positive regulation of keratinocyte differentiation (GO:0045618)2.46314152
161reciprocal DNA recombination (GO:0035825)2.46193622
162reciprocal meiotic recombination (GO:0007131)2.46193622
163DNA damage response, signal transduction resulting in transcription (GO:0042772)2.45885318
164positive regulation of granulocyte differentiation (GO:0030854)2.45503298
165centriole replication (GO:0007099)2.43395085
166negative T cell selection (GO:0043383)2.43067909
167snRNA transcription (GO:0009301)2.42973630
1687-methylguanosine RNA capping (GO:0009452)2.39881590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.19603192
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.54194946
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.17940521
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.06097893
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01809709
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.99285469
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84187389
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57072544
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51087022
10FUS_26573619_Chip-Seq_HEK293_Human2.49382772
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.44067787
12ZNF274_21170338_ChIP-Seq_K562_Hela2.37522973
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.30614253
14TAF15_26573619_Chip-Seq_HEK293_Human2.26387252
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.21852032
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.15674248
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.15573390
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12875247
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.09160170
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.06334029
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05117548
22VDR_22108803_ChIP-Seq_LS180_Human2.04285267
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99776608
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98961960
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96066793
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.94875893
27* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93380382
28HOXB4_20404135_ChIP-ChIP_EML_Mouse1.91491695
29IGF1R_20145208_ChIP-Seq_DFB_Human1.90684747
30P300_19829295_ChIP-Seq_ESCs_Human1.90376685
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89589275
32KAP1_22055183_ChIP-Seq_ESCs_Mouse1.89389989
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.87743812
34* VDR_23849224_ChIP-Seq_CD4+_Human1.87335136
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87320916
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84608743
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84373152
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.79524292
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79359701
40ELK1_19687146_ChIP-ChIP_HELA_Human1.77217304
41* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76683464
42MYB_26560356_Chip-Seq_TH2_Human1.74857814
43AR_21909140_ChIP-Seq_LNCAP_Human1.68693443
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68651391
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.67693398
46GBX2_23144817_ChIP-Seq_PC3_Human1.67144918
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.63781654
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62361343
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.59399656
50* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58443501
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55753580
52* SPI1_23547873_ChIP-Seq_NB4_Human1.55506321
53MYB_26560356_Chip-Seq_TH1_Human1.51712035
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51578986
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49424340
56FOXP3_21729870_ChIP-Seq_TREG_Human1.49251309
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46927153
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.46257165
59ER_23166858_ChIP-Seq_MCF-7_Human1.45415322
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44112788
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43213647
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41782765
63MYC_18940864_ChIP-ChIP_HL60_Human1.41352099
64IRF1_19129219_ChIP-ChIP_H3396_Human1.40299130
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39593544
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38668723
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38471015
68MYC_22102868_ChIP-Seq_BL_Human1.37205836
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37016300
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35849713
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35720768
72RUNX_20019798_ChIP-Seq_JUKART_Human1.32760858
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32635993
74GATA3_27048872_Chip-Seq_THYMUS_Human1.30059294
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30016759
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29552570
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29095951
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28798065
79KDM5A_27292631_Chip-Seq_BREAST_Human1.28794525
80* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27160027
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25191588
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24347964
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23524714
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21117623
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20859892
86* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19697246
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17862104
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17364016
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17059457
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16576069
91CIITA_25753668_ChIP-Seq_RAJI_Human1.15684329
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15655609
93CBP_20019798_ChIP-Seq_JUKART_Human1.15281704
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15281704
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13898713
96STAT3_23295773_ChIP-Seq_U87_Human1.12886842
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12641391
98BCAT_22108803_ChIP-Seq_LS180_Human1.11417603
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.11260813
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10978450
101CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09366619
102GATA1_22025678_ChIP-Seq_K562_Human1.08419136
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08133778
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08011479
105TCF4_23295773_ChIP-Seq_U87_Human1.07334183
106NANOG_16153702_ChIP-ChIP_HESCs_Human1.06602269
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.05101067
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.04957298
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04873198
110GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04444053
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04337068
112SOX2_16153702_ChIP-ChIP_HESCs_Human1.04224232
113MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03990952
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03726596
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03726596
116SMAD4_21799915_ChIP-Seq_A2780_Human1.03691392
117SRF_21415370_ChIP-Seq_HL-1_Mouse1.03409396
118CDX2_22108803_ChIP-Seq_LS180_Human1.02903197
119GABP_19822575_ChIP-Seq_HepG2_Human1.02250574
120GATA3_26560356_Chip-Seq_TH2_Human1.01107153
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00666684
122NANOG_18555785_Chip-Seq_ESCs_Mouse1.00053439
123MYC_18555785_ChIP-Seq_MESCs_Mouse0.99518369
124TCF4_22108803_ChIP-Seq_LS180_Human0.99380034
125* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99351630
126SMAD3_21741376_ChIP-Seq_EPCs_Human0.98576953
127* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98258497
128* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98077406
129TFEB_21752829_ChIP-Seq_HELA_Human0.98006089
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.97712049
131SCL_19346495_ChIP-Seq_HPC-7_Human0.97319592
132* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97206041
133PU_27001747_Chip-Seq_BMDM_Mouse0.96463444
134ETS1_20019798_ChIP-Seq_JURKAT_Human0.95994434
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.95515339
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95423848
137OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94925043
138FLI1_21867929_ChIP-Seq_TH2_Mouse0.94345279
139NANOG_19829295_ChIP-Seq_ESCs_Human0.94221015
140SOX2_19829295_ChIP-Seq_ESCs_Human0.94221015
141DCP1A_22483619_ChIP-Seq_HELA_Human0.94180320
142EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94055103
143TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93972346
144* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93635695
145STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92744025
146MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92491382
147SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92473640
148GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90320545
149UTX_26944678_Chip-Seq_JUKART_Human0.89888753
150RUNX1_22412390_ChIP-Seq_EML_Mouse0.88205533
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86623057
152MAF_26560356_Chip-Seq_TH1_Human0.84877236
153EWS_26573619_Chip-Seq_HEK293_Human0.84605346
154TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83094634
155Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82473508
156NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81751117
157HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81661874
158RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80565363
159STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79634799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.59753616
2MP0001835_abnormal_antigen_presentation3.42723938
3MP0008877_abnormal_DNA_methylation3.38585895
4MP0008057_abnormal_DNA_replication3.07884812
5MP0003763_abnormal_thymus_physiology2.91973003
6MP0010094_abnormal_chromosome_stability2.89265684
7MP0000372_irregular_coat_pigmentation2.87719425
8MP0005671_abnormal_response_to2.84071581
9MP0008007_abnormal_cellular_replicative2.80408278
10MP0003077_abnormal_cell_cycle2.76910920
11MP0003787_abnormal_imprinting2.46920956
12MP0003136_yellow_coat_color2.45076752
13MP0003111_abnormal_nucleus_morphology2.43717912
14MP0008058_abnormal_DNA_repair2.33745669
15MP0001800_abnormal_humoral_immune2.19423324
16MP0009333_abnormal_splenocyte_physiolog2.18335169
17MP0002396_abnormal_hematopoietic_system2.16152961
18MP0002877_abnormal_melanocyte_morpholog2.11712248
19MP0009785_altered_susceptibility_to1.96982636
20MP0002398_abnormal_bone_marrow1.96435707
21MP0001790_abnormal_immune_system1.94127408
22MP0005387_immune_system_phenotype1.94127408
23MP0002006_tumorigenesis1.93353980
24MP0002452_abnormal_antigen_presenting1.92521738
25MP0003195_calcinosis1.92334041
26MP0005075_abnormal_melanosome_morpholog1.92211522
27MP0002420_abnormal_adaptive_immunity1.90424037
28MP0010307_abnormal_tumor_latency1.90044000
29MP0001819_abnormal_immune_cell1.89063990
30MP0004957_abnormal_blastocyst_morpholog1.88888366
31MP0001188_hyperpigmentation1.87846947
32MP0002166_altered_tumor_susceptibility1.87110927
33MP0002723_abnormal_immune_serum1.81980819
34MP0002254_reproductive_system_inflammat1.80965737
35MP0002009_preneoplasia1.79909066
36MP0005000_abnormal_immune_tolerance1.79858512
37MP0009697_abnormal_copulation1.74007427
38MP0000685_abnormal_immune_system1.73258509
39MP0008932_abnormal_embryonic_tissue1.70448322
40MP0000716_abnormal_immune_system1.66777170
41MP0005174_abnormal_tail_pigmentation1.64530759
42MP0005408_hypopigmentation1.63971978
43MP0001853_heart_inflammation1.63961539
44MP0006072_abnormal_retinal_apoptosis1.60475082
45MP0000569_abnormal_digit_pigmentation1.57932665
46MP0004808_abnormal_hematopoietic_stem1.57654415
47MP0003567_abnormal_fetal_cardiomyocyte1.57617082
48MP0000689_abnormal_spleen_morphology1.56791398
49MP0003950_abnormal_plasma_membrane1.53256397
50MP0006292_abnormal_olfactory_placode1.52511456
51MP0002419_abnormal_innate_immunity1.52033341
52MP0005310_abnormal_salivary_gland1.51360838
53MP0002405_respiratory_system_inflammati1.50916558
54MP0005253_abnormal_eye_physiology1.50570167
55MP0000015_abnormal_ear_pigmentation1.49732745
56MP0002638_abnormal_pupillary_reflex1.48284830
57MP0002722_abnormal_immune_system1.47812374
58MP0004264_abnormal_extraembryonic_tissu1.47006926
59MP0005025_abnormal_response_to1.45229288
60MP0002938_white_spotting1.43486544
61MP0003937_abnormal_limbs/digits/tail_de1.43023374
62MP0001119_abnormal_female_reproductive1.42751650
63MP0000350_abnormal_cell_proliferation1.41250646
64MP0002429_abnormal_blood_cell1.39565360
65MP0000703_abnormal_thymus_morphology1.38958565
66MP0003786_premature_aging1.35834167
67MP0010155_abnormal_intestine_physiology1.34913192
68MP0002102_abnormal_ear_morphology1.34224208
69MP0005451_abnormal_body_composition1.34067742
70MP0001984_abnormal_olfaction1.33840863
71MP0005397_hematopoietic_system_phenotyp1.33260138
72MP0001545_abnormal_hematopoietic_system1.33260138
73MP0005171_absent_coat_pigmentation1.32365496
74MP0003718_maternal_effect1.29657780
75MP0005551_abnormal_eye_electrophysiolog1.29156373
76MP0002084_abnormal_developmental_patter1.28432536
77MP0002019_abnormal_tumor_incidence1.28130235
78MP0003941_abnormal_skin_development1.27900426
79MP0000427_abnormal_hair_cycle1.25890732
80MP0002095_abnormal_skin_pigmentation1.25510143
81MP0002148_abnormal_hypersensitivity_rea1.25492367
82MP0001293_anophthalmia1.25071630
83MP0000647_abnormal_sebaceous_gland1.22945416
84MP0001324_abnormal_eye_pigmentation1.22905493
85MP0003221_abnormal_cardiomyocyte_apopto1.22676470
86MP0003121_genomic_imprinting1.22499158
87MP0004147_increased_porphyrin_level1.20926503
88MP0003436_decreased_susceptibility_to1.18742383
89MP0001730_embryonic_growth_arrest1.16516484
90MP0004197_abnormal_fetal_growth/weight/1.15848150
91MP0002210_abnormal_sex_determination1.15774374
92MP0001929_abnormal_gametogenesis1.15576023
93MP0003646_muscle_fatigue1.15102435
94MP0000490_abnormal_crypts_of1.14704050
95MP0001845_abnormal_inflammatory_respons1.14047791
96MP0000516_abnormal_urinary_system1.13464433
97MP0005367_renal/urinary_system_phenotyp1.13464433
98MP0000383_abnormal_hair_follicle1.09745816
99MP0009703_decreased_birth_body1.09451454
100MP0005464_abnormal_platelet_physiology1.08040876
101MP0004133_heterotaxia1.05675734
102MP0010352_gastrointestinal_tract_polyps1.05106429
103MP0001873_stomach_inflammation1.04718590
104MP0008995_early_reproductive_senescence1.03803890
105MP0006035_abnormal_mitochondrial_morpho1.03695709
106MP0003724_increased_susceptibility_to1.00152089
107MP0005187_abnormal_penis_morphology0.98889601
108MP0003119_abnormal_digestive_system0.97704260
109MP0009672_abnormal_birth_weight0.97134142
110MP0000653_abnormal_sex_gland0.96727999
111MP0002751_abnormal_autonomic_nervous0.96254270
112MP0001286_abnormal_eye_development0.96080782
113MP0003828_pulmonary_edema0.95563125
114MP0002090_abnormal_vision0.95137974
115MP0003448_altered_tumor_morphology0.94993915
116MP0001881_abnormal_mammary_gland0.94100201
117MP0001672_abnormal_embryogenesis/_devel0.94011331
118MP0005380_embryogenesis_phenotype0.94011331
119MP0000858_altered_metastatic_potential0.94010907
120MP0003300_gastrointestinal_ulcer0.93422859
121MP0002132_abnormal_respiratory_system0.92388056
122MP0004381_abnormal_hair_follicle0.92302318
123MP0003943_abnormal_hepatobiliary_system0.91388050
124MP0009780_abnormal_chondrocyte_physiolo0.91020307
125MP0003699_abnormal_female_reproductive0.90225799
126MP0003698_abnormal_male_reproductive0.90075558
127MP0001764_abnormal_homeostasis0.90021496
128MP0010678_abnormal_skin_adnexa0.89929276
129MP0002085_abnormal_embryonic_tissue0.89665624
130MP0005395_other_phenotype0.88855416
131MP0000313_abnormal_cell_death0.88805281
132MP0003866_abnormal_defecation0.87277509
133MP0001851_eye_inflammation0.86888774
134MP0003890_abnormal_embryonic-extraembry0.85385001
135MP0001145_abnormal_male_reproductive0.84974824
136MP0000627_abnormal_mammary_gland0.83098794
137MP0002233_abnormal_nose_morphology0.83047496
138MP0000631_abnormal_neuroendocrine_gland0.82469605
139MP0004947_skin_inflammation0.82458257
140MP0003984_embryonic_growth_retardation0.82229385
141MP0001697_abnormal_embryo_size0.81451236
142MP0000371_diluted_coat_color0.80456558
143MP0003045_fibrosis0.79080963
144MP0001915_intracranial_hemorrhage0.79075474
145MP0005389_reproductive_system_phenotype0.79046683
146MP0002086_abnormal_extraembryonic_tissu0.78254770
147MP0006082_CNS_inflammation0.77845430
148MP0002088_abnormal_embryonic_growth/wei0.77823629
149MP0005621_abnormal_cell_physiology0.77591515
150MP0005391_vision/eye_phenotype0.77579666
151MP0004215_abnormal_myocardial_fiber0.76767255
152MP0001986_abnormal_taste_sensitivity0.74811389
153MP0002080_prenatal_lethality0.74690520
154MP0002138_abnormal_hepatobiliary_system0.73493725
155MP0005084_abnormal_gallbladder_morpholo0.72304012
156MP0003183_abnormal_peptide_metabolism0.72218839
157MP0003123_paternal_imprinting0.70820384
158MP0001177_atelectasis0.70294145
159MP0002160_abnormal_reproductive_system0.65846861
160MP0002075_abnormal_coat/hair_pigmentati0.65688902
161MP0002277_abnormal_respiratory_mucosa0.65071171
162MP0001919_abnormal_reproductive_system0.64814395

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.17164228
2Chromsome breakage (HP:0040012)3.98311220
3Type 2 muscle fiber atrophy (HP:0003554)3.97951160
4Abnormal delayed hypersensitivity skin test (HP:0002963)3.97833327
5Abnormality of the fingertips (HP:0001211)3.76127131
6Recurrent viral infections (HP:0004429)3.72485931
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.69023017
8Panhypogammaglobulinemia (HP:0003139)3.65808476
9Agammaglobulinemia (HP:0004432)3.61771697
10Papillary thyroid carcinoma (HP:0002895)3.60119627
11Muscle fiber atrophy (HP:0100295)3.55936810
12Recurrent cutaneous fungal infections (HP:0011370)3.52689466
13Chronic mucocutaneous candidiasis (HP:0002728)3.52689466
14Thrombocytosis (HP:0001894)3.31955603
15Prostate neoplasm (HP:0100787)3.27884561
16Colon cancer (HP:0003003)3.25233379
17Recurrent fungal infections (HP:0002841)3.20422237
18Recurrent bacterial skin infections (HP:0005406)3.19361277
19Recurrent abscess formation (HP:0002722)3.15349879
20Acute myeloid leukemia (HP:0004808)3.09364107
21T lymphocytopenia (HP:0005403)3.06459148
22Capillary hemangiomas (HP:0005306)3.02729311
23Abnormality of the prostate (HP:0008775)2.99288706
24IgM deficiency (HP:0002850)2.96216963
25Myositis (HP:0100614)2.95412801
26Abnormality of T cell number (HP:0011839)2.93531798
27Abnormal spermatogenesis (HP:0008669)2.92480122
28Abnormality of T cells (HP:0002843)2.90484111
29Abnormality of chromosome stability (HP:0003220)2.84776420
30Nephroblastoma (Wilms tumor) (HP:0002667)2.83597098
31Embryonal renal neoplasm (HP:0011794)2.81270352
32IgG deficiency (HP:0004315)2.81021352
33Encephalitis (HP:0002383)2.77469378
34Thyroiditis (HP:0100646)2.72608151
35Abnormality of T cell physiology (HP:0011840)2.69198047
36Amaurosis fugax (HP:0100576)2.66668202
37Azoospermia (HP:0000027)2.65742842
38Retrobulbar optic neuritis (HP:0100654)2.60832764
39Optic neuritis (HP:0100653)2.60832764
40Recurrent skin infections (HP:0001581)2.58383109
41Severe combined immunodeficiency (HP:0004430)2.57148984
42Volvulus (HP:0002580)2.54731969
43Myelodysplasia (HP:0002863)2.54252051
44Recurrent bronchitis (HP:0002837)2.53942379
45Pulmonary fibrosis (HP:0002206)2.53551992
46Villous atrophy (HP:0011473)2.52971796
47Abnormality of small intestinal villus morphology (HP:0011472)2.52971796
48Rhabdomyosarcoma (HP:0002859)2.47454261
49Sloping forehead (HP:0000340)2.45874123
50Abnormality of the renal cortex (HP:0011035)2.43267020
51Renal cortical cysts (HP:0000803)2.42950569
52Combined immunodeficiency (HP:0005387)2.42749490
53Medial flaring of the eyebrow (HP:0010747)2.42299561
54Viral hepatitis (HP:0006562)2.41042333
55Colitis (HP:0002583)2.40696680
56Ependymoma (HP:0002888)2.40598897
57Chronic hepatic failure (HP:0100626)2.40070356
58Duodenal stenosis (HP:0100867)2.40057044
59Small intestinal stenosis (HP:0012848)2.40057044
60Eczematoid dermatitis (HP:0000976)2.39510771
61Agnosia (HP:0010524)2.39339252
62Lip pit (HP:0100267)2.38079337
63Abnormality of eosinophils (HP:0001879)2.37838951
64Neoplasm of the adrenal cortex (HP:0100641)2.37266860
65Abnormal lung lobation (HP:0002101)2.35680048
66Lymphopenia (HP:0001888)2.32459146
67Facial hemangioma (HP:0000329)2.32426440
68Glioma (HP:0009733)2.32153472
69Pulmonary infiltrates (HP:0002113)2.28324034
70Pancreatic islet-cell hyperplasia (HP:0004510)2.26849085
71Meningitis (HP:0001287)2.26769300
72Leukocytosis (HP:0001974)2.26732462
73Medulloblastoma (HP:0002885)2.26326788
74Molar tooth sign on MRI (HP:0002419)2.23493069
75Abnormality of midbrain morphology (HP:0002418)2.23493069
76Gonadotropin excess (HP:0000837)2.23432918
77Patellar aplasia (HP:0006443)2.23137630
78Stomach cancer (HP:0012126)2.22215804
79Arterial thrombosis (HP:0004420)2.22214271
80Biliary tract neoplasm (HP:0100574)2.22100207
81Ectopic kidney (HP:0000086)2.21694619
82Abnormality of the duodenum (HP:0002246)2.19808575
83Lymphoma (HP:0002665)2.19735703
84Abnormality of the preputium (HP:0100587)2.19167300
85Thyroid carcinoma (HP:0002890)2.18293496
86Abnormality of male internal genitalia (HP:0000022)2.16536556
87Nephronophthisis (HP:0000090)2.16034153
88Intestinal atresia (HP:0011100)2.14711855
89Congenital primary aphakia (HP:0007707)2.13234794
90Chronic diarrhea (HP:0002028)2.13090535
91B lymphocytopenia (HP:0010976)2.13027208
92Abnormality of B cell number (HP:0010975)2.13027208
93Abnormality of alanine metabolism (HP:0010916)2.10560756
94Hyperalaninemia (HP:0003348)2.10560756
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10560756
96Clubbing of toes (HP:0100760)2.09964961
97Abnormality of cells of the lymphoid lineage (HP:0012140)2.09777806
98Eosinophilia (HP:0001880)2.08688480
99Astrocytoma (HP:0009592)2.08312553
100Abnormality of the astrocytes (HP:0100707)2.08312553
101Progressive inability to walk (HP:0002505)2.07470249
102Keratoconjunctivitis sicca (HP:0001097)2.07379410
103Pancreatic cysts (HP:0001737)2.06258573
104Meckel diverticulum (HP:0002245)2.05539673
105Absent radius (HP:0003974)2.05488157
106Genital tract atresia (HP:0001827)2.05202358
107Neoplasm of the colon (HP:0100273)2.04160152
108Abnormality of methionine metabolism (HP:0010901)2.04099841
109Stenosis of the external auditory canal (HP:0000402)2.03280938
110Orchitis (HP:0100796)2.02057452
111Aplasia/Hypoplasia of the uvula (HP:0010293)2.02050185
112Aplastic anemia (HP:0001915)2.01144863
113Spondylolisthesis (HP:0003302)2.00972780
114Glucose intolerance (HP:0000833)1.99436087
115Abnormality of the renal medulla (HP:0100957)1.99177320
116Vaginal atresia (HP:0000148)1.98792449
117True hermaphroditism (HP:0010459)1.97275904
118Pancreatic fibrosis (HP:0100732)1.96772354
119Absent forearm bone (HP:0003953)1.96182473
120Aplasia involving forearm bones (HP:0009822)1.96182473
121Aplasia/Hypoplasia of the patella (HP:0006498)1.95803531
122Abnormal hair whorl (HP:0010721)1.94848289
123Gastrointestinal infarctions (HP:0005244)1.94612633
124Gait imbalance (HP:0002141)1.94001974
125Metaphyseal dysplasia (HP:0100255)1.93691780
126IgA deficiency (HP:0002720)1.92563272
127Small hand (HP:0200055)1.92547545
128Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92453584
129Bronchitis (HP:0012387)1.91786741
130Astigmatism (HP:0000483)1.91415952
131Breast hypoplasia (HP:0003187)1.91413763
132Abnormal pancreas size (HP:0012094)1.91068459
133Impulsivity (HP:0100710)1.90613749
134Keratoconjunctivitis (HP:0001096)1.89659883
135Neoplasm of the small intestine (HP:0100833)1.88987586
136Nephrogenic diabetes insipidus (HP:0009806)1.88983669
137Inflammation of the large intestine (HP:0002037)1.88924690
138Abnormality of the ileum (HP:0001549)1.88812614
139Neoplasm of the adrenal gland (HP:0100631)1.87566038
140Breast carcinoma (HP:0003002)1.87300145
141Abolished electroretinogram (ERG) (HP:0000550)1.87055357
142Aqueductal stenosis (HP:0002410)1.86932894
143Methylmalonic acidemia (HP:0002912)1.86139577
144Bone marrow hypocellularity (HP:0005528)1.85783624
145Abnormal biliary tract morphology (HP:0012440)1.84847879
146Abnormality of the labia minora (HP:0012880)1.83741564
147Poor coordination (HP:0002370)1.83536426
148Prominent nose (HP:0000448)1.83106161
149Recurrent lower respiratory tract infections (HP:0002783)1.83055404
150Pendular nystagmus (HP:0012043)1.82229044
151Aplasia/Hypoplasia of the tibia (HP:0005772)1.82007042
152Abnormal biliary tract physiology (HP:0012439)1.81910130
153Bile duct proliferation (HP:0001408)1.81910130
154Vasculitis (HP:0002633)1.81591972
155Male infertility (HP:0003251)1.81057554
156Pustule (HP:0200039)1.80381467
157Ovarian neoplasm (HP:0100615)1.79912501
158Granulocytopenia (HP:0001913)1.79085170
159Spontaneous abortion (HP:0005268)1.79021171
160Homocystinuria (HP:0002156)1.78948632
161Abnormality of homocysteine metabolism (HP:0010919)1.78948632
162Abnormality of the anterior horn cell (HP:0006802)1.77855795
163Degeneration of anterior horn cells (HP:0002398)1.77855795
164Congenital stationary night blindness (HP:0007642)1.77692009
165Cupped ear (HP:0000378)1.77213406
166Attenuation of retinal blood vessels (HP:0007843)1.76136416
167Protruding tongue (HP:0010808)1.76092928
168Abnormality of serum amino acid levels (HP:0003112)1.75086100
169Fair hair (HP:0002286)1.72785789
170Embryonal neoplasm (HP:0002898)1.72373175
171Rectovaginal fistula (HP:0000143)1.69458133
172Rectal fistula (HP:0100590)1.69458133
173Hepatoblastoma (HP:0002884)1.68444549
174Clitoromegaly (HP:0000057)1.68119310
175Tubular atrophy (HP:0000092)1.67955329
176Gaze-evoked nystagmus (HP:0000640)1.67032397
177Tubulointerstitial nephritis (HP:0001970)1.65479110
178Neoplasm of the oral cavity (HP:0100649)1.62508383
179Dandy-Walker malformation (HP:0001305)1.61934208
180Septo-optic dysplasia (HP:0100842)1.61357421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.49387166
2LATS13.09742133
3TRIM282.88218912
4PLK42.71349816
5STK38L2.62377913
6TXK2.62129801
7CDC72.62043064
8JAK32.40181679
9MAP4K12.37777684
10TNIK2.25556001
11ACVR1B2.21543048
12MAP3K142.19197647
13BRSK22.16907738
14IRAK42.08688242
15WNK32.06231654
16NUAK11.99246475
17SRPK11.95805065
18STK31.92213896
19IRAK31.76648527
20TEC1.69199455
21MAP3K41.67679607
22CDK121.66939631
23STK161.66782652
24MKNK21.66523549
25NLK1.65395023
26VRK11.63995340
27PNCK1.62689233
28NEK91.59294009
29IKBKE1.57219424
30STK101.56018370
31MST41.54013835
32ERBB31.53835443
33NEK21.52533120
34MAP4K21.47633024
35LATS21.43400645
36NEK11.42732328
37MAP3K131.40083022
38CHUK1.38050093
39TYK21.37344418
40STK241.36674582
41MARK31.35249759
42PLK31.29306490
43MAP3K61.26288513
44CHEK21.26199407
45TTK1.24402310
46CDK81.23259281
47PLK11.21874835
48PDK21.19471001
49ERBB41.17862381
50STK391.16974703
51JAK11.16656816
52BCR1.16309007
53MAPK131.15959649
54FRK1.13970385
55PBK1.12681935
56CDK91.10552889
57MELK1.10177561
58PLK21.10022361
59IKBKB1.09564043
60FGFR31.08062056
61OXSR11.07066074
62FGFR21.06421969
63EIF2AK21.06065729
64STK41.06021863
65EIF2AK31.03147656
66WEE11.02669797
67AURKB1.02232098
68KIT1.02179739
69ITK1.01521781
70ZAP700.99134492
71BMPR20.98999969
72YES10.98065062
73GRK10.97789307
74SIK30.96908322
75WNK40.93930925
76ZAK0.93494113
77EIF2AK10.92648776
78PIM10.92171424
79CDK30.92126227
80CSNK1G10.92026390
81NEK60.90816574
82DYRK30.88874433
83EPHA30.88526411
84MUSK0.86822844
85TAOK20.86417581
86ATR0.86184401
87CHEK10.85771988
88ATM0.85211024
89CASK0.85118077
90BMPR1B0.84945592
91AKT30.84794132
92TAF10.84642669
93SGK20.82028445
94RPS6KA40.81577718
95TBK10.80087434
96TAOK10.78748703
97FGFR10.78351571
98BRSK10.73743220
99BTK0.71424352
100MKNK10.71298897
101MAP3K80.71108728
102TGFBR10.69183653
103CSNK1G20.68379172
104TRPM70.68308228
105CSNK1A1L0.66692808
106BUB10.66132850
107PASK0.65794910
108CDK70.65609319
109LCK0.65215990
110IRAK10.60989944
111CAMK1G0.59343924
112PAK30.59275424
113MAP3K50.59152964
114ABL10.58685463
115IRAK20.57477260
116CDK190.55832453
117SYK0.55325275
118CLK10.54506507
119BRAF0.52184095
120BRD40.50323157
121CSNK1G30.50040476
122FLT30.48915389
123HIPK20.48373015
124CDK20.47521047
125CDC42BPA0.46099827
126CSNK1E0.44750530
127CSNK1D0.43032045
128JAK20.42843468
129CSK0.42250776
130MAPK110.42072914
131TSSK60.41570895
132FGFR40.41001704
133LYN0.40588847
134CDK10.40368619
135TIE10.39232784
136CSF1R0.38771381
137PRKDC0.38500714
138CDK60.37700841
139ADRBK20.36165454
140PRKCE0.36115444
141INSRR0.36025543
142FER0.34981810
143DYRK1A0.34941613
144MAP2K70.34809227
145FGR0.34395583
146PRKACB0.34166968
147EGFR0.33428071
148OBSCN0.31224408
149CSNK2A10.30749833
150CSNK2A20.30451725
151CAMK1D0.28813246

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030202.97546901
2Primary immunodeficiency_Homo sapiens_hsa053402.96553798
3Basal transcription factors_Homo sapiens_hsa030222.90013407
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57084481
5Cell cycle_Homo sapiens_hsa041102.50804117
6RNA degradation_Homo sapiens_hsa030182.42967421
7Mismatch repair_Homo sapiens_hsa034302.27490793
8Propanoate metabolism_Homo sapiens_hsa006402.23453546
9Antigen processing and presentation_Homo sapiens_hsa046122.21492942
10Homologous recombination_Homo sapiens_hsa034402.20966872
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.18899927
12Fanconi anemia pathway_Homo sapiens_hsa034602.12922166
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11185527
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06428315
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.05918504
16Herpes simplex infection_Homo sapiens_hsa051682.00569896
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.96273741
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.92528645
19RNA transport_Homo sapiens_hsa030131.90392869
20Steroid biosynthesis_Homo sapiens_hsa001001.89315997
21DNA replication_Homo sapiens_hsa030301.87282012
22Measles_Homo sapiens_hsa051621.82070815
23p53 signaling pathway_Homo sapiens_hsa041151.77274410
24Graft-versus-host disease_Homo sapiens_hsa053321.76295502
25Non-homologous end-joining_Homo sapiens_hsa034501.75929661
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70116043
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66940861
28Spliceosome_Homo sapiens_hsa030401.64351780
29Selenocompound metabolism_Homo sapiens_hsa004501.63899546
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63535057
31Base excision repair_Homo sapiens_hsa034101.57946408
32Influenza A_Homo sapiens_hsa051641.56469500
33Allograft rejection_Homo sapiens_hsa053301.53572054
34Nucleotide excision repair_Homo sapiens_hsa034201.50868375
35Hematopoietic cell lineage_Homo sapiens_hsa046401.44130476
36Leishmaniasis_Homo sapiens_hsa051401.41972076
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40856344
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.39265852
39mRNA surveillance pathway_Homo sapiens_hsa030151.36581363
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.36346029
41Epstein-Barr virus infection_Homo sapiens_hsa051691.35133633
42T cell receptor signaling pathway_Homo sapiens_hsa046601.28608643
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27926030
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26697385
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26672487
46Butanoate metabolism_Homo sapiens_hsa006501.25343808
47Vitamin B6 metabolism_Homo sapiens_hsa007501.23638562
48Pyrimidine metabolism_Homo sapiens_hsa002401.22530533
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20210572
50Phototransduction_Homo sapiens_hsa047441.19684853
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17683282
52Hepatitis B_Homo sapiens_hsa051611.11072565
53Pancreatic cancer_Homo sapiens_hsa052121.09037870
54Ether lipid metabolism_Homo sapiens_hsa005651.08378117
55Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08131880
56Nitrogen metabolism_Homo sapiens_hsa009101.07597626
57Type I diabetes mellitus_Homo sapiens_hsa049401.06050558
58Toxoplasmosis_Homo sapiens_hsa051451.04237025
59Viral carcinogenesis_Homo sapiens_hsa052031.04054154
60Protein export_Homo sapiens_hsa030601.03105190
61Osteoclast differentiation_Homo sapiens_hsa043801.01175933
62Lysine degradation_Homo sapiens_hsa003100.98436996
63Autoimmune thyroid disease_Homo sapiens_hsa053200.96655628
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95822779
65Circadian rhythm_Homo sapiens_hsa047100.94556153
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92644114
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92631357
68Prolactin signaling pathway_Homo sapiens_hsa049170.92479008
69B cell receptor signaling pathway_Homo sapiens_hsa046620.91412015
70Tuberculosis_Homo sapiens_hsa051520.88831743
71Purine metabolism_Homo sapiens_hsa002300.88271250
72TNF signaling pathway_Homo sapiens_hsa046680.87841601
73FoxO signaling pathway_Homo sapiens_hsa040680.87654952
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87270076
75MicroRNAs in cancer_Homo sapiens_hsa052060.84384943
76TGF-beta signaling pathway_Homo sapiens_hsa043500.84269818
77HTLV-I infection_Homo sapiens_hsa051660.84153233
78Caffeine metabolism_Homo sapiens_hsa002320.83961251
79Shigellosis_Homo sapiens_hsa051310.83580438
80Viral myocarditis_Homo sapiens_hsa054160.83152673
81Peroxisome_Homo sapiens_hsa041460.82067464
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81906134
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81281373
84Pentose phosphate pathway_Homo sapiens_hsa000300.78139218
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77593314
86Vitamin digestion and absorption_Homo sapiens_hsa049770.76477958
87Chemokine signaling pathway_Homo sapiens_hsa040620.76140272
88Malaria_Homo sapiens_hsa051440.75795379
89Legionellosis_Homo sapiens_hsa051340.74760412
90Proteasome_Homo sapiens_hsa030500.74535041
91Hepatitis C_Homo sapiens_hsa051600.72440199
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71983826
93Small cell lung cancer_Homo sapiens_hsa052220.71842920
94Linoleic acid metabolism_Homo sapiens_hsa005910.71833072
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71446766
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71310833
97Colorectal cancer_Homo sapiens_hsa052100.70717983
98Apoptosis_Homo sapiens_hsa042100.70563854
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69642799
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69100359
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.67895509
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65217239
103Thyroid cancer_Homo sapiens_hsa052160.65164519
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.64461200
105Fatty acid metabolism_Homo sapiens_hsa012120.61695736
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59676809
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.59064808
108Oocyte meiosis_Homo sapiens_hsa041140.58123036
109Prostate cancer_Homo sapiens_hsa052150.56921705
110Rheumatoid arthritis_Homo sapiens_hsa053230.56686226
111Olfactory transduction_Homo sapiens_hsa047400.56331858
112Adherens junction_Homo sapiens_hsa045200.56241771
113Regulation of autophagy_Homo sapiens_hsa041400.56030945
114Pyruvate metabolism_Homo sapiens_hsa006200.53313719
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53061305
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52004755
117Fatty acid elongation_Homo sapiens_hsa000620.51773268
118ABC transporters_Homo sapiens_hsa020100.51376272
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50030869
120Taste transduction_Homo sapiens_hsa047420.48578553
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48214656
122Systemic lupus erythematosus_Homo sapiens_hsa053220.47238164
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47085106
124Salmonella infection_Homo sapiens_hsa051320.45922468
125Notch signaling pathway_Homo sapiens_hsa043300.45510518
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45137163
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.45059516
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44858024
129Dorso-ventral axis formation_Homo sapiens_hsa043200.44763861
130Fatty acid degradation_Homo sapiens_hsa000710.44522695
131Asthma_Homo sapiens_hsa053100.44370385
132Platelet activation_Homo sapiens_hsa046110.44108591
133Pertussis_Homo sapiens_hsa051330.43646253
134Acute myeloid leukemia_Homo sapiens_hsa052210.43314452
135Metabolic pathways_Homo sapiens_hsa011000.42327309
136Sphingolipid metabolism_Homo sapiens_hsa006000.42068784
137Other glycan degradation_Homo sapiens_hsa005110.41385777
138Tryptophan metabolism_Homo sapiens_hsa003800.40405187
139Retinol metabolism_Homo sapiens_hsa008300.40205971
140Chronic myeloid leukemia_Homo sapiens_hsa052200.39411126
141beta-Alanine metabolism_Homo sapiens_hsa004100.36411620
142Nicotine addiction_Homo sapiens_hsa050330.34968793
143Hippo signaling pathway_Homo sapiens_hsa043900.34443887
144Wnt signaling pathway_Homo sapiens_hsa043100.34306913
145One carbon pool by folate_Homo sapiens_hsa006700.34083675
146Fat digestion and absorption_Homo sapiens_hsa049750.32636282
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29783651
148Endometrial cancer_Homo sapiens_hsa052130.29700000
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27347369
150Fatty acid biosynthesis_Homo sapiens_hsa000610.25908588
151Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24852374
152Tight junction_Homo sapiens_hsa045300.24676965
153Alcoholism_Homo sapiens_hsa050340.21376596
154Glycerolipid metabolism_Homo sapiens_hsa005610.21219443
155Huntingtons disease_Homo sapiens_hsa050160.20646766
1562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16634561
157Glycerophospholipid metabolism_Homo sapiens_hsa005640.16598900
158Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16590110

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