ESCO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.85049940
2protein localization to kinetochore (GO:0034501)5.57297975
3synapsis (GO:0007129)5.56261088
4metaphase plate congression (GO:0051310)5.09373236
5attachment of spindle microtubules to kinetochore (GO:0008608)5.08433991
6kinetochore organization (GO:0051383)5.03961417
7CENP-A containing nucleosome assembly (GO:0034080)5.01641443
8chromatin remodeling at centromere (GO:0031055)4.99275480
9DNA replication checkpoint (GO:0000076)4.92395896
10mitotic chromosome condensation (GO:0007076)4.90766207
11protein localization to chromosome, centromeric region (GO:0071459)4.85020695
12DNA replication initiation (GO:0006270)4.62187575
13regulation of spindle organization (GO:0090224)4.60812547
14DNA replication-independent nucleosome organization (GO:0034724)4.60803259
15DNA replication-independent nucleosome assembly (GO:0006336)4.60803259
16mitotic sister chromatid segregation (GO:0000070)4.59758601
17kinetochore assembly (GO:0051382)4.57926207
18regulation of meiosis I (GO:0060631)4.57529771
19regulation of DNA endoreduplication (GO:0032875)4.55479117
20meiotic chromosome segregation (GO:0045132)4.54788207
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.48568720
22piRNA metabolic process (GO:0034587)4.47829010
23establishment of chromosome localization (GO:0051303)4.47354871
24nuclear pore organization (GO:0006999)4.41687250
25DNA strand elongation involved in DNA replication (GO:0006271)4.35347160
26histone exchange (GO:0043486)4.35282708
27chromosome organization involved in meiosis (GO:0070192)4.32412085
28DNA replication-dependent nucleosome assembly (GO:0006335)4.30291546
29DNA replication-dependent nucleosome organization (GO:0034723)4.30291546
30telomere maintenance via semi-conservative replication (GO:0032201)4.25416860
31sister chromatid segregation (GO:0000819)4.22227499
32nuclear pore complex assembly (GO:0051292)4.20938476
33DNA strand elongation (GO:0022616)4.16476996
34mitotic nuclear envelope disassembly (GO:0007077)4.16258749
35centriole replication (GO:0007099)4.14067545
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.13813881
37spindle checkpoint (GO:0031577)4.12098621
38telomere maintenance via recombination (GO:0000722)4.06730722
39mitotic recombination (GO:0006312)4.06575123
40regulation of mitotic spindle organization (GO:0060236)4.06030385
41male meiosis I (GO:0007141)4.05621692
42protein K6-linked ubiquitination (GO:0085020)4.04585760
43positive regulation of chromosome segregation (GO:0051984)4.03426915
44purine nucleobase biosynthetic process (GO:0009113)4.03416621
45nucleobase biosynthetic process (GO:0046112)3.99732527
46regulation of chromosome segregation (GO:0051983)3.95252093
47DNA double-strand break processing (GO:0000729)3.88352784
48nuclear envelope disassembly (GO:0051081)3.86847852
49membrane disassembly (GO:0030397)3.86847852
50negative regulation of chromosome segregation (GO:0051985)3.86051496
51spindle assembly checkpoint (GO:0071173)3.83977050
52negative regulation of mitotic sister chromatid segregation (GO:0033048)3.83753022
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.83753022
54negative regulation of sister chromatid segregation (GO:0033046)3.83753022
55negative regulation of mitotic sister chromatid separation (GO:2000816)3.83753022
56regulation of mitotic metaphase/anaphase transition (GO:0030071)3.82049675
57DNA unwinding involved in DNA replication (GO:0006268)3.79199047
58regulation of double-strand break repair via homologous recombination (GO:0010569)3.78801228
59mitotic spindle checkpoint (GO:0071174)3.78546411
60regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.78305127
61regulation of mitotic spindle checkpoint (GO:1903504)3.78305127
62negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.76693573
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.76633358
64mitotic spindle assembly checkpoint (GO:0007094)3.73394901
65sister chromatid cohesion (GO:0007062)3.67105443
66telomere maintenance via telomere lengthening (GO:0010833)3.63760040
67* chromosome segregation (GO:0007059)3.63234217
68regulation of mitotic sister chromatid separation (GO:0010965)3.63086500
69regulation of mitotic sister chromatid segregation (GO:0033047)3.63086500
70regulation of sister chromatid segregation (GO:0033045)3.63086500
71meiosis I (GO:0007127)3.60868178
72meiotic cell cycle (GO:0051321)3.59609025
73regulation of sister chromatid cohesion (GO:0007063)3.57153971
74meiotic cell cycle process (GO:1903046)3.56893988
75ribosome assembly (GO:0042255)3.56327652
76DNA methylation involved in gamete generation (GO:0043046)3.55334670
77postreplication repair (GO:0006301)3.53518241
78chromatin assembly or disassembly (GO:0006333)3.53179117
79male meiosis (GO:0007140)3.50473017
80translesion synthesis (GO:0019985)3.49596367
81positive regulation of mitotic sister chromatid separation (GO:1901970)3.49536440
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49536440
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49536440
84meiotic nuclear division (GO:0007126)3.48924302
85regulation of centrosome cycle (GO:0046605)3.48674929
86* protein localization to chromosome (GO:0034502)3.48483360
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.46892215
88microtubule depolymerization (GO:0007019)3.45737118
89nucleotide-excision repair, DNA gap filling (GO:0006297)3.45457736
90DNA ligation (GO:0006266)3.44813212
91DNA synthesis involved in DNA repair (GO:0000731)3.44549208
92regulation of nuclear cell cycle DNA replication (GO:0033262)3.42401090
93ATP-dependent chromatin remodeling (GO:0043044)3.32639803
94recombinational repair (GO:0000725)3.32476456
95pore complex assembly (GO:0046931)3.32151867
96double-strand break repair via homologous recombination (GO:0000724)3.31162586
97mitotic sister chromatid cohesion (GO:0007064)3.29186218
98DNA catabolic process, exonucleolytic (GO:0000738)3.27094549
99ribosome biogenesis (GO:0042254)3.24149689
100negative regulation of DNA-dependent DNA replication (GO:2000104)3.20168869
101mismatch repair (GO:0006298)3.18080334
102somatic hypermutation of immunoglobulin genes (GO:0016446)3.17508054
103somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17508054
104resolution of meiotic recombination intermediates (GO:0000712)3.16799888
105IMP biosynthetic process (GO:0006188)3.15909918
106proteasome assembly (GO:0043248)3.13432494
107maturation of 5.8S rRNA (GO:0000460)3.11648623
108regulation of centriole replication (GO:0046599)3.11415670
109chromosome condensation (GO:0030261)3.10574096
110replication fork processing (GO:0031297)3.09446729
111negative regulation of mitosis (GO:0045839)3.09110106
112regulation of telomere maintenance via telomerase (GO:0032210)3.07713027
113chromosome organization (GO:0051276)3.06405679
114telomere maintenance (GO:0000723)3.04609657
115* mitotic cell cycle (GO:0000278)3.04266341
116telomere organization (GO:0032200)3.04043546
117maturation of SSU-rRNA (GO:0030490)3.02901593
118nuclear envelope organization (GO:0006998)3.01457010
119transcription-coupled nucleotide-excision repair (GO:0006283)3.00866890
120synaptonemal complex assembly (GO:0007130)3.00744546
121reciprocal meiotic recombination (GO:0007131)3.00011603
122reciprocal DNA recombination (GO:0035825)3.00011603
123regulation of histone H3-K9 methylation (GO:0051570)2.98299319
124DNA geometric change (GO:0032392)2.97940108
125mitotic G2/M transition checkpoint (GO:0044818)2.95663893
126DNA duplex unwinding (GO:0032508)2.95272989

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.01767054
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.58976880
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.04972516
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.75970350
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11583461
6AR_21909140_ChIP-Seq_LNCAP_Human2.82393382
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80332101
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73336735
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.69779385
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.65503847
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63497482
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54711389
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50476764
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49778694
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.46273516
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.44449925
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40319788
18* ETS1_20019798_ChIP-Seq_JURKAT_Human2.36984619
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36707587
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.36668415
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35586052
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23910928
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23522198
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11844497
25VDR_23849224_ChIP-Seq_CD4+_Human2.08303463
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02622448
27EWS_26573619_Chip-Seq_HEK293_Human2.02373562
28XRN2_22483619_ChIP-Seq_HELA_Human2.00633930
29E2F7_22180533_ChIP-Seq_HELA_Human10.3345430
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.97905392
31ZNF274_21170338_ChIP-Seq_K562_Hela1.97559979
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96063120
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.82703384
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80963364
35VDR_22108803_ChIP-Seq_LS180_Human1.80640355
36FOXP3_21729870_ChIP-Seq_TREG_Human1.78877439
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77820577
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75885500
39DCP1A_22483619_ChIP-Seq_HELA_Human1.71411724
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.70207069
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.65135050
42FUS_26573619_Chip-Seq_HEK293_Human1.64550648
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61385431
44TTF2_22483619_ChIP-Seq_HELA_Human1.60951036
45* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60877846
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60100630
47GABP_19822575_ChIP-Seq_HepG2_Human1.59470366
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56438530
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55922729
50ELK1_19687146_ChIP-ChIP_HELA_Human1.55788382
51EZH2_22144423_ChIP-Seq_EOC_Human1.53590916
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.50030901
53IRF1_19129219_ChIP-ChIP_H3396_Human1.49924844
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49777079
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49591114
56IGF1R_20145208_ChIP-Seq_DFB_Human1.42865650
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42742621
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42737114
59KDM5A_27292631_Chip-Seq_BREAST_Human1.41579896
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40444253
61CIITA_25753668_ChIP-Seq_RAJI_Human1.36854848
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35881877
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35287102
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31797570
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30305658
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30003426
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29911549
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27984467
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.25763289
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.23501112
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23219806
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19004645
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18659370
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18515768
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15268048
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14428524
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10488320
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10488320
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10488320
80TAF15_26573619_Chip-Seq_HEK293_Human1.10429596
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08787114
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.07757422
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05702792
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05693950
85P300_19829295_ChIP-Seq_ESCs_Human1.05654497
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05565698
87MYC_18940864_ChIP-ChIP_HL60_Human1.03804592
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.03799005
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02125300
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00160062
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97930461
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97647004
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96795032
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96523626
95GBX2_23144817_ChIP-Seq_PC3_Human0.96152937
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95746783
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94988406
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93827079
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93495907
100MYC_22102868_ChIP-Seq_BL_Human0.92830169
101ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91158592
102TFEB_21752829_ChIP-Seq_HELA_Human0.90285086
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90063936
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89926049
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89438074
106ER_23166858_ChIP-Seq_MCF-7_Human0.89027664
107TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88792154
108TP53_22573176_ChIP-Seq_HFKS_Human0.88501178
109PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88149774
110SOX2_16153702_ChIP-ChIP_HESCs_Human0.87955097
111NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87579271
112SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87119560
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86152737
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85971056
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85893477
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84479718
117TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82924045
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82755085
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81625750
120CBP_20019798_ChIP-Seq_JUKART_Human0.81625750
121KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81019772
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80249759
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.78628672
124* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78269095
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78141487
126HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78090785
127* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.76759771
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76664618
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.76630840
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76044163
131CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75522100
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.75152090
133EZH2_27294783_Chip-Seq_NPCs_Mouse0.74156803
134FOXA1_25329375_ChIP-Seq_VCAP_Human0.72404210
135FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72404210
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.71830903
137NANOG_16153702_ChIP-ChIP_HESCs_Human0.71354143
138ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70967677
139SOX2_18692474_ChIP-Seq_MESCs_Mouse0.70612872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.99274379
2MP0010094_abnormal_chromosome_stability5.40255048
3MP0003111_abnormal_nucleus_morphology5.12089245
4MP0008057_abnormal_DNA_replication4.48179050
5MP0004957_abnormal_blastocyst_morpholog4.42023826
6MP0003077_abnormal_cell_cycle4.37609856
7MP0008058_abnormal_DNA_repair3.79404298
8MP0008877_abnormal_DNA_methylation3.43561191
9MP0008007_abnormal_cellular_replicative2.81180222
10MP0008932_abnormal_embryonic_tissue2.75292834
11MP0003718_maternal_effect2.72094309
12MP0003123_paternal_imprinting2.64234362
13MP0003786_premature_aging2.41886957
14MP0000350_abnormal_cell_proliferation2.33501232
15MP0001730_embryonic_growth_arrest2.31292054
16MP0010307_abnormal_tumor_latency2.25940757
17MP0008789_abnormal_olfactory_epithelium2.13348963
18MP0002396_abnormal_hematopoietic_system1.92459339
19MP0002210_abnormal_sex_determination1.87964806
20MP0001672_abnormal_embryogenesis/_devel1.85070600
21MP0005380_embryogenesis_phenotype1.85070600
22MP0001697_abnormal_embryo_size1.73508156
23MP0003121_genomic_imprinting1.72286544
24MP0002085_abnormal_embryonic_tissue1.63647566
25MP0001929_abnormal_gametogenesis1.58811021
26MP0005394_taste/olfaction_phenotype1.56274142
27MP0005499_abnormal_olfactory_system1.56274142
28MP0003984_embryonic_growth_retardation1.56118215
29MP0001145_abnormal_male_reproductive1.55613189
30MP0006292_abnormal_olfactory_placode1.54830788
31MP0002088_abnormal_embryonic_growth/wei1.51325142
32MP0002234_abnormal_pharynx_morphology1.51278005
33MP0002080_prenatal_lethality1.48094671
34MP0000653_abnormal_sex_gland1.48061050
35MP0002084_abnormal_developmental_patter1.47506257
36MP0010352_gastrointestinal_tract_polyps1.45954299
37MP0000569_abnormal_digit_pigmentation1.43880672
38MP0006072_abnormal_retinal_apoptosis1.41180515
39MP0000490_abnormal_crypts_of1.39441664
40MP0003315_abnormal_perineum_morphology1.38685780
41MP0000313_abnormal_cell_death1.38635885
42MP0002086_abnormal_extraembryonic_tissu1.37162370
43MP0000427_abnormal_hair_cycle1.33485866
44MP0003890_abnormal_embryonic-extraembry1.31223259
45MP0002019_abnormal_tumor_incidence1.30554349
46MP0003941_abnormal_skin_development1.30251114
47MP0001119_abnormal_female_reproductive1.27967134
48MP0003567_abnormal_fetal_cardiomyocyte1.23261632
49MP0002102_abnormal_ear_morphology1.22339603
50MP0005076_abnormal_cell_differentiation1.21026698
51MP0004197_abnormal_fetal_growth/weight/1.19496696
52MP0002938_white_spotting1.18765893
53MP0004808_abnormal_hematopoietic_stem1.11350291
54MP0003937_abnormal_limbs/digits/tail_de1.08666066
55MP0005551_abnormal_eye_electrophysiolog1.07553849
56MP0000372_irregular_coat_pigmentation1.06898535
57MP0001293_anophthalmia1.06017377
58MP0002653_abnormal_ependyma_morphology1.04329407
59MP0000631_abnormal_neuroendocrine_gland1.00663864
60MP0003787_abnormal_imprinting1.00555054
61MP0008995_early_reproductive_senescence1.00434079
62MP0003950_abnormal_plasma_membrane0.99323238
63MP0002160_abnormal_reproductive_system0.97536228
64MP0004147_increased_porphyrin_level0.97236651
65MP0002095_abnormal_skin_pigmentation0.97016246
66MP0003699_abnormal_female_reproductive0.95855824
67MP0006035_abnormal_mitochondrial_morpho0.95023345
68MP0005174_abnormal_tail_pigmentation0.94923122
69MP0005397_hematopoietic_system_phenotyp0.92961501
70MP0001545_abnormal_hematopoietic_system0.92961501
71MP0002233_abnormal_nose_morphology0.92262319
72MP0005389_reproductive_system_phenotype0.92240974
73MP0005395_other_phenotype0.91559018
74MP0003136_yellow_coat_color0.91128198
75MP0005253_abnormal_eye_physiology0.90400322
76MP0005410_abnormal_fertilization0.90283460
77MP0003646_muscle_fatigue0.89132102
78MP0003698_abnormal_male_reproductive0.86340942
79MP0009333_abnormal_splenocyte_physiolog0.81386116
80MP0008260_abnormal_autophagy0.81013101
81MP0006036_abnormal_mitochondrial_physio0.80741462
82MP0005621_abnormal_cell_physiology0.80215842
83MP0009672_abnormal_birth_weight0.79915743
84MP0005384_cellular_phenotype0.79768760
85MP0002161_abnormal_fertility/fecundity0.79413804
86MP0000647_abnormal_sebaceous_gland0.78788033
87MP0000703_abnormal_thymus_morphology0.78725184
88MP0002163_abnormal_gland_morphology0.77162790
89MP0000049_abnormal_middle_ear0.75980133
90MP0005647_abnormal_sex_gland0.75830490
91MP0003806_abnormal_nucleotide_metabolis0.75451869
92MP0001286_abnormal_eye_development0.73715117
93MP0002751_abnormal_autonomic_nervous0.73111722
94MP0002111_abnormal_tail_morphology0.73093011
95MP0002638_abnormal_pupillary_reflex0.73062748
96MP0003119_abnormal_digestive_system0.72760419
97MP0001529_abnormal_vocalization0.72381004
98MP0003195_calcinosis0.72372711
99MP0010030_abnormal_orbit_morphology0.71841230
100MP0000015_abnormal_ear_pigmentation0.71383657
101MP0009703_decreased_birth_body0.71332355
102MP0001984_abnormal_olfaction0.67168142
103MP0005391_vision/eye_phenotype0.66477841
104MP0004264_abnormal_extraembryonic_tissu0.66141874
105MP0002722_abnormal_immune_system0.65038431
106MP0001485_abnormal_pinna_reflex0.64887820
107MP0006276_abnormal_autonomic_nervous0.64653191
108MP0001324_abnormal_eye_pigmentation0.64565261
109MP0002398_abnormal_bone_marrow0.64012286
110MP0002132_abnormal_respiratory_system0.63382144
111MP0001919_abnormal_reproductive_system0.63201530
112MP0001915_intracranial_hemorrhage0.62588984
113MP0000689_abnormal_spleen_morphology0.62239503
114MP0002092_abnormal_eye_morphology0.61156946
115MP0002736_abnormal_nociception_after0.60747236
116MP0010678_abnormal_skin_adnexa0.60616539
117MP0003221_abnormal_cardiomyocyte_apopto0.60413565
118MP0003936_abnormal_reproductive_system0.57948869
119MP0000432_abnormal_head_morphology0.57920691
120MP0003763_abnormal_thymus_physiology0.56528913
121MP0001764_abnormal_homeostasis0.56151899
122MP0004133_heterotaxia0.54967006
123MP0003755_abnormal_palate_morphology0.54358206
124MP0000358_abnormal_cell_content/0.53694004
125MP0000566_synostosis0.53276026
126MP0000428_abnormal_craniofacial_morphol0.52195912
127MP0009053_abnormal_anal_canal0.52160078
128MP0000627_abnormal_mammary_gland0.51838378
129MP0003938_abnormal_ear_development0.51258767
130MP0003861_abnormal_nervous_system0.50508232
131MP0009697_abnormal_copulation0.50295735
132MP0003186_abnormal_redox_activity0.49484622
133MP0000537_abnormal_urethra_morphology0.48474639
134MP0005377_hearing/vestibular/ear_phenot0.47690679
135MP0003878_abnormal_ear_physiology0.47690679
136MP0005451_abnormal_body_composition0.47468779
137MP0000383_abnormal_hair_follicle0.46513111
138MP0002429_abnormal_blood_cell0.44988502

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.15209805
2Chromsome breakage (HP:0040012)5.88647069
3Chromosomal breakage induced by crosslinking agents (HP:0003221)5.74401386
4Breast hypoplasia (HP:0003187)4.87425674
5Abnormality of chromosome stability (HP:0003220)4.45192963
6Meckel diverticulum (HP:0002245)4.13792364
7Impulsivity (HP:0100710)4.13393691
8Abnormality of the preputium (HP:0100587)4.08776427
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.95998897
10Abnormality of the ileum (HP:0001549)3.89657486
11Carpal bone hypoplasia (HP:0001498)3.77108468
12* Patellar aplasia (HP:0006443)3.66214787
13Small intestinal stenosis (HP:0012848)3.51668303
14Duodenal stenosis (HP:0100867)3.51668303
15* Aplasia/Hypoplasia of the patella (HP:0006498)3.40404757
16Medulloblastoma (HP:0002885)3.14477256
17Oral leukoplakia (HP:0002745)3.03293299
18Myelodysplasia (HP:0002863)3.03211874
19Reticulocytopenia (HP:0001896)3.02632107
20Ependymoma (HP:0002888)3.02550095
21Ectopic kidney (HP:0000086)3.01148578
22Colon cancer (HP:0003003)2.99865097
23Selective tooth agenesis (HP:0001592)2.88525760
24* Absent radius (HP:0003974)2.87305650
25Absent thumb (HP:0009777)2.86707952
26Sloping forehead (HP:0000340)2.86632154
27Abnormality of the duodenum (HP:0002246)2.86119024
28Bone marrow hypocellularity (HP:0005528)2.82711551
29Duplicated collecting system (HP:0000081)2.81079057
30Abnormal lung lobation (HP:0002101)2.77664298
31Rough bone trabeculation (HP:0100670)2.76700150
32Abnormality of the anterior horn cell (HP:0006802)2.76427595
33Degeneration of anterior horn cells (HP:0002398)2.76427595
34Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.73230362
35Molar tooth sign on MRI (HP:0002419)2.71010029
36Abnormality of midbrain morphology (HP:0002418)2.71010029
37* Absent forearm bone (HP:0003953)2.68013336
38* Aplasia involving forearm bones (HP:0009822)2.68013336
39Agnosia (HP:0010524)2.66165843
40Rhabdomyosarcoma (HP:0002859)2.64413231
41Abnormal spermatogenesis (HP:0008669)2.63138952
42Clubbing of toes (HP:0100760)2.60214833
43Abnormality of the carotid arteries (HP:0005344)2.58056367
44Nephroblastoma (Wilms tumor) (HP:0002667)2.57597592
45Pancreatic cysts (HP:0001737)2.55833434
46Abnormality of the renal collecting system (HP:0004742)2.50875755
47Pancreatic fibrosis (HP:0100732)2.47550365
48Triphalangeal thumb (HP:0001199)2.47048610
49Volvulus (HP:0002580)2.44203800
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.41510129
51Neoplasm of the pancreas (HP:0002894)2.39679082
52Embryonal renal neoplasm (HP:0011794)2.38590563
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.36129315
54Tracheoesophageal fistula (HP:0002575)2.35500663
55Cerebral hypomyelination (HP:0006808)2.28899132
56Ureteral duplication (HP:0000073)2.25844756
57Increased nuchal translucency (HP:0010880)2.25318788
58Premature ovarian failure (HP:0008209)2.25094978
59Shawl scrotum (HP:0000049)2.23423481
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.21590329
61* Abnormality of the labia minora (HP:0012880)2.21053090
62Prominent nose (HP:0000448)2.20393703
63True hermaphroditism (HP:0010459)2.19814196
6411 pairs of ribs (HP:0000878)2.16950385
65* Cafe-au-lait spot (HP:0000957)2.16295790
66Neoplasm of the oral cavity (HP:0100649)2.15342807
67Breast aplasia (HP:0100783)2.13915646
68Septo-optic dysplasia (HP:0100842)2.13821424
69Abnormality of DNA repair (HP:0003254)2.13815336
70Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13000249
71Premature graying of hair (HP:0002216)2.12745923
72Secondary amenorrhea (HP:0000869)2.12401250
73Abnormal trabecular bone morphology (HP:0100671)2.12234167
74Preaxial hand polydactyly (HP:0001177)2.11719251
75Short tibia (HP:0005736)2.10685979
76Aplastic anemia (HP:0001915)2.09725330
77* Short thumb (HP:0009778)2.09092976
78Small hand (HP:0200055)2.07050538
79Azoospermia (HP:0000027)2.06923000
80Abnormal number of incisors (HP:0011064)2.06795814
81Hypoplasia of the pons (HP:0012110)2.06672538
82Atresia of the external auditory canal (HP:0000413)2.06211741
83Abnormality of the pons (HP:0007361)2.05374374
84Aplasia/Hypoplasia of the breasts (HP:0010311)2.05154655
85Absent septum pellucidum (HP:0001331)2.03893714
86Squamous cell carcinoma (HP:0002860)2.03121831
87Biliary tract neoplasm (HP:0100574)2.02924909
88Gonadotropin excess (HP:0000837)2.02820324
89Median cleft lip (HP:0000161)2.02816365
90Glioma (HP:0009733)2.02716607
91Neoplasm of the colon (HP:0100273)1.99374743
92Microretrognathia (HP:0000308)1.98487540
93Proximal placement of thumb (HP:0009623)1.98297976
94Pendular nystagmus (HP:0012043)1.97342270
95Astrocytoma (HP:0009592)1.96253968
96Abnormality of the astrocytes (HP:0100707)1.96253968
97Cellular immunodeficiency (HP:0005374)1.95171106
98* Horseshoe kidney (HP:0000085)1.94170243
99Nephronophthisis (HP:0000090)1.94017482
100Astigmatism (HP:0000483)1.91116361
101Deviation of the thumb (HP:0009603)1.90082016
102Abnormality of the septum pellucidum (HP:0007375)1.88508597
103Oligohydramnios (HP:0001562)1.87621882
104Hyperglycinemia (HP:0002154)1.87317754
105Choanal atresia (HP:0000453)1.85929735
106Aplasia/hypoplasia of the humerus (HP:0006507)1.85657156
107Dandy-Walker malformation (HP:0001305)1.84958933
108Embryonal neoplasm (HP:0002898)1.84627037
109Bile duct proliferation (HP:0001408)1.82596844
110Abnormal biliary tract physiology (HP:0012439)1.82596844
111Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81835962
112Abnormality of alanine metabolism (HP:0010916)1.81835962
113Hyperalaninemia (HP:0003348)1.81835962
114Arteriovenous malformation (HP:0100026)1.81554800
115Neoplasm of striated muscle (HP:0009728)1.81549517
116Abnormal biliary tract morphology (HP:0012440)1.80449850
117Abdominal situs inversus (HP:0003363)1.80128625
118Abnormality of abdominal situs (HP:0011620)1.80128625
119Anencephaly (HP:0002323)1.79853020
120* Supernumerary spleens (HP:0009799)1.79141016
121Basal cell carcinoma (HP:0002671)1.77667360
122Spinal muscular atrophy (HP:0007269)1.76788144
123Overlapping toe (HP:0001845)1.74237021
124Slender long bone (HP:0003100)1.73939789
125Increased CSF lactate (HP:0002490)1.73687071
126Hypoplasia of the fovea (HP:0007750)1.72417937
127Aplasia/Hypoplasia of the fovea (HP:0008060)1.72417937
128Microtia (HP:0008551)1.72402741
129Abnormality of the renal cortex (HP:0011035)1.71349131
130Methylmalonic acidemia (HP:0002912)1.71228609
131Optic nerve hypoplasia (HP:0000609)1.70082469
132Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69330654
133Abnormality of the renal medulla (HP:0100957)1.69120805
134Lymphoma (HP:0002665)1.69093113
135Abnormality of cells of the erythroid lineage (HP:0012130)1.68421319
136High pitched voice (HP:0001620)1.67632557
137Sclerocornea (HP:0000647)1.66176388
138Hypoplastic pelvis (HP:0008839)1.65818053
139Acute necrotizing encephalopathy (HP:0006965)1.65475870
140Irregular epiphyses (HP:0010582)1.64183513
141Pancytopenia (HP:0001876)1.64004777
142Abnormality of pyrimidine metabolism (HP:0004353)1.63772432
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63755601
144Aganglionic megacolon (HP:0002251)1.63506063
145Acute encephalopathy (HP:0006846)1.63069567
146Tubulointerstitial nephritis (HP:0001970)1.61419843
147Postaxial foot polydactyly (HP:0001830)1.61231816
148Cystic liver disease (HP:0006706)1.61050514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.91621379
2BUB14.49161806
3CDC74.46632802
4TTK3.42469641
5NEK23.38501688
6PLK43.03167957
7EIF2AK13.00213353
8SRPK12.86278184
9BRSK22.80637972
10PLK12.63401476
11NEK12.60520773
12ACVR1B2.46812882
13BMPR1B2.20251134
14FRK2.14755331
15PLK32.06307320
16AURKB1.99510060
17CHEK21.92502148
18EIF2AK31.87149831
19CCNB11.80718565
20MKNK21.77527477
21BRSK11.76241961
22MST41.76188806
23TSSK61.74264687
24VRK11.72253106
25MKNK11.71939789
26ATR1.71185128
27CDK121.70057951
28VRK21.57640342
29CDK71.55707683
30TRIM281.53422663
31ZAK1.50338212
32DYRK31.46834906
33WNK31.43103234
34STK41.42065712
35CHEK11.39334165
36STK161.36126035
37STK38L1.34407771
38TLK11.33321309
39EPHA21.32348928
40AURKA1.30900765
41TAF11.30300486
42MAP3K81.29779089
43BRAF1.25964840
44MELK1.25575367
45CDK41.23384178
46TNIK1.17937151
47RPS6KB21.15266653
48STK101.14681749
49STK31.14328779
50ATM1.13225411
51RPS6KA41.10346733
52NME21.09586024
53STK391.07157086
54PASK1.01161796
55OXSR10.96047262
56CDK20.94579685
57AKT30.93353562
58EIF2AK20.92072240
59PLK20.90450522
60PNCK0.88075854
61LATS10.85450249
62MET0.84724984
63BRD40.82484040
64CDK10.81982114
65PIM10.81412624
66WNK40.80053210
67INSRR0.78867437
68CDK80.78620881
69EEF2K0.77560947
70TESK20.76802194
71LATS20.76259601
72PBK0.74069108
73GRK10.72053748
74MAPK130.67049659
75MAP4K20.63853308
76CDK60.63732763
77CLK10.59400815
78MAP3K90.59237721
79PRKCI0.59002683
80CSNK2A10.58783794
81NME10.54995361
82CSNK2A20.54374333
83RPS6KA50.53121354
84ADRBK20.51728021
85ALK0.51186033
86ERBB30.49786163
87CASK0.49266815
88MAP3K40.46990223
89NUAK10.45461908
90PAK10.44463226
91TAOK30.43561099
92TGFBR10.42596582
93NEK60.41584353
94CSNK1G20.41156116
95MAP3K60.40904559
96NEK90.40852550
97CDK90.40375741
98PAK40.39552933
99SCYL20.37908630
100DYRK20.36224495
101PRKDC0.35074920
102CSNK1E0.34779722
103CDK30.34712899
104CSNK1D0.31397070
105MAPK140.30131894
106MAPKAPK30.29775069
107MAPKAPK50.28629985
108ERBB40.26235349
109RAF10.25872009
110CAMK1G0.25560950
111PKN10.24928640
112MUSK0.24115753
113GSK3B0.23012944
114KSR10.22924699
115PINK10.22714428
116CSNK1G30.22694619
117AKT10.22151210
118CHUK0.22038368
119MTOR0.21512848
120CSNK1G10.21125419
121STK240.20839623
122MARK30.20829799
123AKT20.18927132
124MAPK10.17939141
125PDK30.17720021
126PDK40.17720021
127PDK20.14528104
128BCR0.10685650
129FLT30.10220100
130CSNK1A1L0.09979643
131PRKAA10.09785908

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.88362652
2Mismatch repair_Homo sapiens_hsa034304.41905695
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.94550612
4Homologous recombination_Homo sapiens_hsa034403.63908381
5Cell cycle_Homo sapiens_hsa041103.54300085
6RNA polymerase_Homo sapiens_hsa030203.34486532
7RNA transport_Homo sapiens_hsa030133.31294785
8Base excision repair_Homo sapiens_hsa034103.14815107
9Fanconi anemia pathway_Homo sapiens_hsa034603.10190945
10Spliceosome_Homo sapiens_hsa030403.09583043
11Nucleotide excision repair_Homo sapiens_hsa034203.03426787
12Basal transcription factors_Homo sapiens_hsa030222.58060955
13One carbon pool by folate_Homo sapiens_hsa006702.43027735
14Pyrimidine metabolism_Homo sapiens_hsa002402.42595933
15Proteasome_Homo sapiens_hsa030502.37756916
16Non-homologous end-joining_Homo sapiens_hsa034502.29444435
17RNA degradation_Homo sapiens_hsa030182.21667794
18Vitamin B6 metabolism_Homo sapiens_hsa007502.14693238
19p53 signaling pathway_Homo sapiens_hsa041152.08141831
20Ribosome_Homo sapiens_hsa030102.00365216
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94235732
22mRNA surveillance pathway_Homo sapiens_hsa030151.94226877
23Propanoate metabolism_Homo sapiens_hsa006401.49037072
24Oocyte meiosis_Homo sapiens_hsa041141.48161578
25Purine metabolism_Homo sapiens_hsa002301.42052720
26Systemic lupus erythematosus_Homo sapiens_hsa053221.41680799
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.31801323
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28486496
29Caffeine metabolism_Homo sapiens_hsa002321.26788192
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23768067
31Epstein-Barr virus infection_Homo sapiens_hsa051691.18894160
32Parkinsons disease_Homo sapiens_hsa050121.16700355
33Oxidative phosphorylation_Homo sapiens_hsa001901.15117422
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12888518
35Viral carcinogenesis_Homo sapiens_hsa052031.00781416
36Herpes simplex infection_Homo sapiens_hsa051680.95930890
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94694353
38Phototransduction_Homo sapiens_hsa047440.94295072
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89919456
40Pyruvate metabolism_Homo sapiens_hsa006200.89581466
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89119771
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82148352
43Folate biosynthesis_Homo sapiens_hsa007900.82123532
44MicroRNAs in cancer_Homo sapiens_hsa052060.79078231
45Pentose phosphate pathway_Homo sapiens_hsa000300.78814285
46Steroid biosynthesis_Homo sapiens_hsa001000.75125663
47Butanoate metabolism_Homo sapiens_hsa006500.74473120
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.73050405
49HTLV-I infection_Homo sapiens_hsa051660.72878140
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69857722
51Antigen processing and presentation_Homo sapiens_hsa046120.64861132
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.63704236
53TGF-beta signaling pathway_Homo sapiens_hsa043500.60768455
54Fatty acid elongation_Homo sapiens_hsa000620.59591935
55Olfactory transduction_Homo sapiens_hsa047400.59241803
56Small cell lung cancer_Homo sapiens_hsa052220.58908280
57Biosynthesis of amino acids_Homo sapiens_hsa012300.58251075
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57411361
59Selenocompound metabolism_Homo sapiens_hsa004500.56928707
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56074927
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55988549
62Tryptophan metabolism_Homo sapiens_hsa003800.50955361
63Alcoholism_Homo sapiens_hsa050340.50779542
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.49124957
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47172644
66Alzheimers disease_Homo sapiens_hsa050100.46699463
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46107846
68Thyroid cancer_Homo sapiens_hsa052160.45329766
69Hippo signaling pathway_Homo sapiens_hsa043900.43682651
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43312841
71Regulation of autophagy_Homo sapiens_hsa041400.41701095
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39480814
73Nitrogen metabolism_Homo sapiens_hsa009100.38704730
74Colorectal cancer_Homo sapiens_hsa052100.38223216
75Glutathione metabolism_Homo sapiens_hsa004800.37128371
76Nicotine addiction_Homo sapiens_hsa050330.36021702
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35624769
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.33462700
79FoxO signaling pathway_Homo sapiens_hsa040680.33119336
80Hepatitis B_Homo sapiens_hsa051610.31739586
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30853464
82Notch signaling pathway_Homo sapiens_hsa043300.30793239
83Peroxisome_Homo sapiens_hsa041460.30788375
84Apoptosis_Homo sapiens_hsa042100.30738829
85Ether lipid metabolism_Homo sapiens_hsa005650.30001253
86Basal cell carcinoma_Homo sapiens_hsa052170.28469294
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28146284
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27966350
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.27487895
90N-Glycan biosynthesis_Homo sapiens_hsa005100.27393069
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27390828
92Primary immunodeficiency_Homo sapiens_hsa053400.27372675
93Ovarian steroidogenesis_Homo sapiens_hsa049130.26265695
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25736050
95beta-Alanine metabolism_Homo sapiens_hsa004100.25107193
96Linoleic acid metabolism_Homo sapiens_hsa005910.24508146
97Prostate cancer_Homo sapiens_hsa052150.24414121
98Retinol metabolism_Homo sapiens_hsa008300.23774451
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23073391
100Circadian rhythm_Homo sapiens_hsa047100.22688865
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22168218
102Influenza A_Homo sapiens_hsa051640.22143620
103Fatty acid metabolism_Homo sapiens_hsa012120.21839653
104Pathways in cancer_Homo sapiens_hsa052000.21536960
105Adherens junction_Homo sapiens_hsa045200.21431617
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20687613
107Huntingtons disease_Homo sapiens_hsa050160.20079925
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19672359
109Measles_Homo sapiens_hsa051620.19263341
110Arachidonic acid metabolism_Homo sapiens_hsa005900.18896987
111Taste transduction_Homo sapiens_hsa047420.18781512
112Legionellosis_Homo sapiens_hsa051340.18585775
113mTOR signaling pathway_Homo sapiens_hsa041500.18412494
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.17803880
115Pancreatic cancer_Homo sapiens_hsa052120.17677272
116Hedgehog signaling pathway_Homo sapiens_hsa043400.17209840
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17125976
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.14809263
119Vitamin digestion and absorption_Homo sapiens_hsa049770.14576554
120Lysine degradation_Homo sapiens_hsa003100.14055908
121Metabolic pathways_Homo sapiens_hsa011000.13679724
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13666835
123Bladder cancer_Homo sapiens_hsa052190.12221837
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.11979148
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11477011
126HIF-1 signaling pathway_Homo sapiens_hsa040660.11414105
127Chronic myeloid leukemia_Homo sapiens_hsa052200.11328080
128Hematopoietic cell lineage_Homo sapiens_hsa046400.09229622
129Carbon metabolism_Homo sapiens_hsa012000.09148247
130Protein export_Homo sapiens_hsa030600.08985190
131Fructose and mannose metabolism_Homo sapiens_hsa000510.08453481
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.06981553
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.05796353
134Wnt signaling pathway_Homo sapiens_hsa043100.05468389
135Melanoma_Homo sapiens_hsa052180.04647252
136Shigellosis_Homo sapiens_hsa051310.04224377
137Sulfur relay system_Homo sapiens_hsa041220.04111162
138Renin-angiotensin system_Homo sapiens_hsa046140.03715045
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03620627

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