ESF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.82149763
2mitotic metaphase plate congression (GO:0007080)4.24218003
3nuclear pore organization (GO:0006999)4.23720174
4kinetochore organization (GO:0051383)4.18388189
5ribosomal small subunit biogenesis (GO:0042274)4.17625723
6nuclear pore complex assembly (GO:0051292)4.16999030
7ribosomal large subunit biogenesis (GO:0042273)4.10641458
8establishment of integrated proviral latency (GO:0075713)4.00574774
9chromatin remodeling at centromere (GO:0031055)3.87557498
10CENP-A containing nucleosome assembly (GO:0034080)3.82778324
11metaphase plate congression (GO:0051310)3.79259118
12ribonucleoprotein complex biogenesis (GO:0022613)3.79180850
13ribosome assembly (GO:0042255)3.76157056
14kinetochore assembly (GO:0051382)3.67699322
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.65553756
16DNA replication initiation (GO:0006270)3.60963819
17regulation of centriole replication (GO:0046599)3.55531941
18formation of translation preinitiation complex (GO:0001731)3.55224851
19rRNA processing (GO:0006364)3.54643835
20ribosome biogenesis (GO:0042254)3.49193263
21regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.48952945
22regulation of mitotic spindle checkpoint (GO:1903504)3.48952945
23rRNA metabolic process (GO:0016072)3.44582935
24translational termination (GO:0006415)3.40528740
25chaperone-mediated protein transport (GO:0072321)3.39836745
26termination of RNA polymerase III transcription (GO:0006386)3.38750500
27transcription elongation from RNA polymerase III promoter (GO:0006385)3.38750500
28negative regulation of DNA-dependent DNA replication (GO:2000104)3.37228039
29histone exchange (GO:0043486)3.35019248
30viral transcription (GO:0019083)3.34890594
317-methylguanosine RNA capping (GO:0009452)3.32531391
32RNA capping (GO:0036260)3.32531391
33ribosomal small subunit assembly (GO:0000028)3.30178981
34DNA replication-independent nucleosome assembly (GO:0006336)3.29113568
35DNA replication-independent nucleosome organization (GO:0034724)3.29113568
367-methylguanosine mRNA capping (GO:0006370)3.28282438
37replication fork processing (GO:0031297)3.28258627
38centriole replication (GO:0007099)3.28215233
39histone mRNA metabolic process (GO:0008334)3.26731410
40transcription elongation from RNA polymerase I promoter (GO:0006362)3.26422814
41DNA unwinding involved in DNA replication (GO:0006268)3.23875505
42DNA replication-dependent nucleosome assembly (GO:0006335)3.22258412
43DNA replication-dependent nucleosome organization (GO:0034723)3.22258412
44mitotic sister chromatid cohesion (GO:0007064)3.20802475
45regulation of mitochondrial translation (GO:0070129)3.19761237
46DNA replication checkpoint (GO:0000076)3.19649831
47translational initiation (GO:0006413)3.15475808
48pore complex assembly (GO:0046931)3.14866864
49nucleobase biosynthetic process (GO:0046112)3.14617231
50attachment of spindle microtubules to kinetochore (GO:0008608)3.12045829
51meiotic chromosome segregation (GO:0045132)3.12007738
52DNA ligation (GO:0006266)3.11819682
53termination of RNA polymerase I transcription (GO:0006363)3.10584064
54establishment of viral latency (GO:0019043)3.10497789
55regulation of DNA endoreduplication (GO:0032875)3.07707029
56DNA strand elongation involved in DNA replication (GO:0006271)3.07163638
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06904590
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.06544977
59rRNA modification (GO:0000154)3.05126709
60spliceosomal snRNP assembly (GO:0000387)3.04911966
61cellular component biogenesis (GO:0044085)3.04714402
62establishment of chromosome localization (GO:0051303)3.03737700
63pseudouridine synthesis (GO:0001522)3.03519085
64spliceosomal complex assembly (GO:0000245)3.03199983
65RNA-dependent DNA replication (GO:0006278)3.01645138
66telomere maintenance via telomerase (GO:0007004)3.00422804
67spindle checkpoint (GO:0031577)2.99736665
68purine nucleobase biosynthetic process (GO:0009113)2.97709034
69mitochondrial respiratory chain complex assembly (GO:0033108)2.96849577
70rRNA methylation (GO:0031167)2.96080432
71DNA double-strand break processing (GO:0000729)2.95974379
72protein complex biogenesis (GO:0070271)2.95855520
73regulation of helicase activity (GO:0051095)2.94155739
74transcription from RNA polymerase I promoter (GO:0006360)2.93559656
75protein localization to kinetochore (GO:0034501)2.92460070
76double-strand break repair via nonhomologous end joining (GO:0006303)2.92363543
77non-recombinational repair (GO:0000726)2.92363543
78regulation of nuclear cell cycle DNA replication (GO:0033262)2.92085459
79mitotic nuclear envelope disassembly (GO:0007077)2.92068858
80DNA strand elongation (GO:0022616)2.91830952
81maturation of 5.8S rRNA (GO:0000460)2.91798763
82transcription-coupled nucleotide-excision repair (GO:0006283)2.91713756
83negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91319421
84cotranslational protein targeting to membrane (GO:0006613)2.90768348
85proteasome assembly (GO:0043248)2.90235404
86mitotic spindle checkpoint (GO:0071174)2.87516780
87nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86479132
88SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.86074569
89telomere maintenance via semi-conservative replication (GO:0032201)2.85421702
90DNA damage response, detection of DNA damage (GO:0042769)2.84933296
91protein targeting to ER (GO:0045047)2.84162725
92regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84153731
93regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84153731
94transcription initiation from RNA polymerase I promoter (GO:0006361)2.83143339
95translational elongation (GO:0006414)2.82130173
96IMP biosynthetic process (GO:0006188)2.81287553
97otic vesicle formation (GO:0030916)2.81274760
98resolution of meiotic recombination intermediates (GO:0000712)2.80749690
99termination of RNA polymerase II transcription (GO:0006369)2.80393798
100regulation of centrosome cycle (GO:0046605)2.80223480
101ATP synthesis coupled proton transport (GO:0015986)2.78679543
102energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78679543
103mitotic G2/M transition checkpoint (GO:0044818)2.77713291
104synapsis (GO:0007129)2.77624615
105ATP-dependent chromatin remodeling (GO:0043044)2.77578625
106microtubule depolymerization (GO:0007019)2.77082449
107cellular protein complex disassembly (GO:0043624)2.76237669
108spindle assembly checkpoint (GO:0071173)2.75848756
109mitochondrial respiratory chain complex I assembly (GO:0032981)2.75698859
110NADH dehydrogenase complex assembly (GO:0010257)2.75698859
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75698859
112regulation of sister chromatid segregation (GO:0033045)2.75271671
113regulation of mitotic sister chromatid separation (GO:0010965)2.75271671
114regulation of mitotic sister chromatid segregation (GO:0033047)2.75271671
115negative regulation of sister chromatid segregation (GO:0033046)2.75163136
116negative regulation of mitotic sister chromatid separation (GO:2000816)2.75163136
117negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75163136
118negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.75163136
119maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75129386
120translation (GO:0006412)2.74957008
121telomere maintenance via telomere lengthening (GO:0010833)2.74208403
122somatic hypermutation of immunoglobulin genes (GO:0016446)2.73795841
123somatic diversification of immune receptors via somatic mutation (GO:0002566)2.73795841
124establishment of protein localization to endoplasmic reticulum (GO:0072599)2.73794254
125GTP biosynthetic process (GO:0006183)2.73709719
126mitotic recombination (GO:0006312)2.72926447
127negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.72185333
128UTP biosynthetic process (GO:0006228)2.71976896
129mitotic sister chromatid segregation (GO:0000070)2.71799384
130mitotic spindle assembly checkpoint (GO:0007094)2.71461576
131nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70873547
132somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.70866212
133isotype switching (GO:0045190)2.70866212
134somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.70866212
135negative regulation of chromosome segregation (GO:0051985)2.70687858
136DNA-templated transcription, termination (GO:0006353)2.69893755
137exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.69659075
138water-soluble vitamin biosynthetic process (GO:0042364)2.69657553
139chromatin assembly or disassembly (GO:0006333)2.68672616
140protein localization to chromosome, centromeric region (GO:0071459)2.66226139
141respiratory electron transport chain (GO:0022904)2.65835966
142negative regulation of DNA recombination (GO:0045910)2.64940861

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.07299547
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.23597042
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.84210506
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.72634194
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.49506204
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.34328487
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.31585300
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.00349342
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.88844006
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84491269
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.81184716
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.80492506
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.73610479
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72412818
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.70804129
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68220764
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59409662
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54323277
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.52692385
20ELK1_19687146_ChIP-ChIP_HELA_Human2.48049414
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34288965
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32214889
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31445422
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26647502
25VDR_23849224_ChIP-Seq_CD4+_Human2.25082475
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17337542
27AR_21909140_ChIP-Seq_LNCAP_Human2.14070071
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.09515724
29FUS_26573619_Chip-Seq_HEK293_Human2.06394053
30TTF2_22483619_ChIP-Seq_HELA_Human1.99645625
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95930209
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94968335
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91092375
34XRN2_22483619_ChIP-Seq_HELA_Human1.87310616
35ZNF274_21170338_ChIP-Seq_K562_Hela1.83488543
36* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83263581
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82947169
38* FOXP3_21729870_ChIP-Seq_TREG_Human1.81824002
39* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77256822
40DCP1A_22483619_ChIP-Seq_HELA_Human1.76282411
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76256970
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.76122860
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68141405
44EWS_26573619_Chip-Seq_HEK293_Human1.67350864
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67167263
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.64807601
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.63900109
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.63900109
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.63900109
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62276279
51* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60540795
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59535009
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55866618
54IGF1R_20145208_ChIP-Seq_DFB_Human1.50656741
55P300_19829295_ChIP-Seq_ESCs_Human1.50561544
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42266770
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39670288
58GABP_19822575_ChIP-Seq_HepG2_Human1.34899509
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34783837
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31237563
61ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.30321404
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29475495
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28686206
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28669068
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.27676735
66* NOTCH1_21737748_ChIP-Seq_TLL_Human1.27236821
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24522634
68MYC_18940864_ChIP-ChIP_HL60_Human1.24162929
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.22268121
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22138351
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.21875245
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21610955
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16018408
74TAF15_26573619_Chip-Seq_HEK293_Human1.15108502
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12826756
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10102247
77IRF1_19129219_ChIP-ChIP_H3396_Human1.09625880
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08104404
79KDM5A_27292631_Chip-Seq_BREAST_Human1.06803556
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06740688
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06327979
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05631513
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05144410
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.04745549
85SOX2_16153702_ChIP-ChIP_HESCs_Human1.02806927
86GBX2_23144817_ChIP-Seq_PC3_Human1.02805952
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02634741
88CBP_20019798_ChIP-Seq_JUKART_Human1.02045881
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02045881
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02042226
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00205957
92VDR_22108803_ChIP-Seq_LS180_Human0.99976394
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99940100
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95951965
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94093958
96ER_23166858_ChIP-Seq_MCF-7_Human0.93070558
97SOX17_20123909_ChIP-Seq_XEN_Mouse0.92095880
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.92080392
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90320909
100TP53_22573176_ChIP-Seq_HFKS_Human0.88932991
101TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88346840
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87375762
103* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86725488
104ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86453677
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84915729
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84603672
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83215951
108NANOG_16153702_ChIP-ChIP_HESCs_Human0.82942824
109BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81739649
110SMAD3_21741376_ChIP-Seq_EPCs_Human0.81344723
111SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79466907
112CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79219987
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76255392
114RNF2_27304074_Chip-Seq_NSC_Mouse0.74770550
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69443927
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.68572707
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.68548490
118SUZ12_27294783_Chip-Seq_NPCs_Mouse0.68242563
119CIITA_25753668_ChIP-Seq_RAJI_Human0.67691947
120ELF5_23300383_ChIP-Seq_T47D_Human0.67017034
121PCGF2_27294783_Chip-Seq_NPCs_Mouse0.65822719
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.65212261
123NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.65126080
124CTBP1_25329375_ChIP-Seq_LNCAP_Human0.65085603
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.65041355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.28342795
2MP0003693_abnormal_embryo_hatching3.82050375
3MP0008877_abnormal_DNA_methylation3.50343751
4MP0004957_abnormal_blastocyst_morpholog3.48260479
5MP0010094_abnormal_chromosome_stability3.45370036
6MP0003123_paternal_imprinting3.07208403
7MP0003111_abnormal_nucleus_morphology3.03732736
8MP0003077_abnormal_cell_cycle2.76633460
9MP0008058_abnormal_DNA_repair2.73936322
10MP0009379_abnormal_foot_pigmentation2.65286693
11MP0008932_abnormal_embryonic_tissue2.52838093
12MP0001188_hyperpigmentation2.27495988
13MP0003121_genomic_imprinting2.12405263
14MP0006292_abnormal_olfactory_placode2.08807359
15MP0008007_abnormal_cellular_replicative2.02427957
16MP0003786_premature_aging1.99720137
17MP0003136_yellow_coat_color1.93986556
18MP0003787_abnormal_imprinting1.85544722
19MP0003941_abnormal_skin_development1.80586751
20MP0003890_abnormal_embryonic-extraembry1.76848157
21MP0001730_embryonic_growth_arrest1.75786573
22MP0003937_abnormal_limbs/digits/tail_de1.72596313
23MP0001529_abnormal_vocalization1.71121528
24MP0000350_abnormal_cell_proliferation1.59863028
25MP0003315_abnormal_perineum_morphology1.54561376
26MP0002163_abnormal_gland_morphology1.54325857
27MP0003718_maternal_effect1.48346269
28MP0008789_abnormal_olfactory_epithelium1.44594759
29MP0002234_abnormal_pharynx_morphology1.42667902
30MP0003950_abnormal_plasma_membrane1.42506998
31MP0002938_white_spotting1.38160000
32MP0001697_abnormal_embryo_size1.32924159
33MP0005380_embryogenesis_phenotype1.30226879
34MP0001672_abnormal_embryogenesis/_devel1.30226879
35MP0006072_abnormal_retinal_apoptosis1.29439511
36MP0005409_darkened_coat_color1.29039700
37MP0002084_abnormal_developmental_patter1.28464915
38MP0002736_abnormal_nociception_after1.27881518
39MP0001485_abnormal_pinna_reflex1.27825953
40MP0002085_abnormal_embryonic_tissue1.27509822
41MP0003567_abnormal_fetal_cardiomyocyte1.27063735
42MP0000566_synostosis1.25221923
43MP0001293_anophthalmia1.22375022
44MP0002210_abnormal_sex_determination1.22036517
45MP0002102_abnormal_ear_morphology1.21887459
46MP0000049_abnormal_middle_ear1.21198891
47MP0001286_abnormal_eye_development1.18033412
48MP0001984_abnormal_olfaction1.17612473
49MP0003938_abnormal_ear_development1.16471679
50MP0009697_abnormal_copulation1.14257569
51MP0003984_embryonic_growth_retardation1.12641999
52MP0005171_absent_coat_pigmentation1.11918371
53MP0003755_abnormal_palate_morphology1.11184163
54MP0002088_abnormal_embryonic_growth/wei1.08599563
55MP0000516_abnormal_urinary_system1.08409023
56MP0005367_renal/urinary_system_phenotyp1.08409023
57MP0004197_abnormal_fetal_growth/weight/1.06712458
58MP0000762_abnormal_tongue_morphology1.04214121
59MP0001145_abnormal_male_reproductive1.02889823
60MP0010030_abnormal_orbit_morphology1.01550590
61MP0005551_abnormal_eye_electrophysiolog1.00962688
62MP0003186_abnormal_redox_activity0.99681063
63MP0005499_abnormal_olfactory_system0.98363831
64MP0005394_taste/olfaction_phenotype0.98363831
65MP0003880_abnormal_central_pattern0.98240022
66MP0009250_abnormal_appendicular_skeleto0.98047780
67MP0002080_prenatal_lethality0.97135938
68MP0004133_heterotaxia0.96943003
69MP0000432_abnormal_head_morphology0.96665251
70MP0002751_abnormal_autonomic_nervous0.95844160
71MP0002233_abnormal_nose_morphology0.95629585
72MP0002160_abnormal_reproductive_system0.95531068
73MP0008995_early_reproductive_senescence0.94355740
74MP0003122_maternal_imprinting0.94149803
75MP0005253_abnormal_eye_physiology0.93491594
76MP0006035_abnormal_mitochondrial_morpho0.90995807
77MP0002396_abnormal_hematopoietic_system0.90977660
78MP0005379_endocrine/exocrine_gland_phen0.90726301
79MP0000653_abnormal_sex_gland0.90352950
80MP0001929_abnormal_gametogenesis0.89773820
81MP0002086_abnormal_extraembryonic_tissu0.89438519
82MP0005391_vision/eye_phenotype0.88423715
83MP0003698_abnormal_male_reproductive0.85825888
84MP0010307_abnormal_tumor_latency0.83937086
85MP0001968_abnormal_touch/_nociception0.83649970
86MP0003385_abnormal_body_wall0.83358914
87MP0002277_abnormal_respiratory_mucosa0.83255080
88MP0003861_abnormal_nervous_system0.83239799
89MP0003119_abnormal_digestive_system0.82974547
90MP0006036_abnormal_mitochondrial_physio0.82531691
91MP0001299_abnormal_eye_distance/0.81061814
92MP0000537_abnormal_urethra_morphology0.80927424
93MP0000631_abnormal_neuroendocrine_gland0.78960854
94MP0003195_calcinosis0.78763809
95MP0004885_abnormal_endolymph0.77761268
96MP0000313_abnormal_cell_death0.77226373
97MP0005389_reproductive_system_phenotype0.77011706
98MP0002184_abnormal_innervation0.75508374
99MP0009053_abnormal_anal_canal0.75135794
100MP0004147_increased_porphyrin_level0.74959645
101MP0002272_abnormal_nervous_system0.74949613
102MP0005623_abnormal_meninges_morphology0.74624164
103MP0002114_abnormal_axial_skeleton0.74308367
104MP0002092_abnormal_eye_morphology0.74208847
105MP0005084_abnormal_gallbladder_morpholo0.73345625
106MP0001905_abnormal_dopamine_level0.73192519
107MP0005195_abnormal_posterior_eye0.72967913
108MP0002752_abnormal_somatic_nervous0.72358348
109MP0004142_abnormal_muscle_tone0.72047955
110MP0002116_abnormal_craniofacial_bone0.70951628
111MP0000428_abnormal_craniofacial_morphol0.70943781
112MP0000647_abnormal_sebaceous_gland0.70538334
113MP0000778_abnormal_nervous_system0.70271692
114MP0002254_reproductive_system_inflammat0.69974009
115MP0005395_other_phenotype0.69016593
116MP0001119_abnormal_female_reproductive0.68828112
117MP0009703_decreased_birth_body0.68815610
118MP0005408_hypopigmentation0.68564477
119MP0002735_abnormal_chemical_nociception0.67283514
120MP0009046_muscle_twitch0.67140912
121MP0003935_abnormal_craniofacial_develop0.67059528
122MP0002177_abnormal_outer_ear0.67050029
123MP0000383_abnormal_hair_follicle0.65446723
124MP0002111_abnormal_tail_morphology0.65206825
125MP0002697_abnormal_eye_size0.64183769
126MP0002638_abnormal_pupillary_reflex0.63400599
127MP0010352_gastrointestinal_tract_polyps0.63288723
128MP0003936_abnormal_reproductive_system0.62386681
129MP0000613_abnormal_salivary_gland0.61751164
130MP0004145_abnormal_muscle_electrophysio0.61702076

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.67487731
2Breast hypoplasia (HP:0003187)3.21209434
3Abnormality of the labia minora (HP:0012880)3.17377673
4Chromsome breakage (HP:0040012)3.09903731
5Reticulocytopenia (HP:0001896)3.01797768
6Volvulus (HP:0002580)2.90653642
7Absent radius (HP:0003974)2.81153686
8Acute necrotizing encephalopathy (HP:0006965)2.79331906
9Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75027272
10Abnormality of midbrain morphology (HP:0002418)2.72315495
11Molar tooth sign on MRI (HP:0002419)2.72315495
12Stenosis of the external auditory canal (HP:0000402)2.66114497
13Abnormality of chromosome stability (HP:0003220)2.65625077
14Aplasia involving forearm bones (HP:0009822)2.64648218
15Absent forearm bone (HP:0003953)2.64648218
16Supernumerary spleens (HP:0009799)2.63810261
17Cerebral hypomyelination (HP:0006808)2.62973890
18Abnormality of the preputium (HP:0100587)2.62864007
19Increased hepatocellular lipid droplets (HP:0006565)2.59155909
20Macrocytic anemia (HP:0001972)2.53393044
21Methylmalonic acidemia (HP:0002912)2.52164399
22Cerebral edema (HP:0002181)2.46110095
23Progressive macrocephaly (HP:0004481)2.42971719
24Meckel diverticulum (HP:0002245)2.42013542
25Carpal bone hypoplasia (HP:0001498)2.39239900
26Patellar aplasia (HP:0006443)2.36188617
27Abnormality of cells of the erythroid lineage (HP:0012130)2.35407479
28True hermaphroditism (HP:0010459)2.32659714
29Nephronophthisis (HP:0000090)2.32601675
30Irregular epiphyses (HP:0010582)2.31109771
31Nephroblastoma (Wilms tumor) (HP:0002667)2.29366553
32Abnormality of the ileum (HP:0001549)2.26680377
33Median cleft lip (HP:0000161)2.24884414
34Abnormal mitochondria in muscle tissue (HP:0008316)2.24072954
35Mitochondrial inheritance (HP:0001427)2.23506824
36Rough bone trabeculation (HP:0100670)2.22642529
37Abnormal number of incisors (HP:0011064)2.22041238
38Aplasia/Hypoplasia of the patella (HP:0006498)2.17197910
3911 pairs of ribs (HP:0000878)2.15927665
40Horseshoe kidney (HP:0000085)2.15578777
41Hyperglycinemia (HP:0002154)2.15561466
42Triphalangeal thumb (HP:0001199)2.15287251
43Colon cancer (HP:0003003)2.14194891
44Embryonal renal neoplasm (HP:0011794)2.14171399
45Facial hemangioma (HP:0000329)2.09886844
46Renal cortical cysts (HP:0000803)2.09482096
47Optic nerve hypoplasia (HP:0000609)2.08989271
48Aplasia cutis congenita (HP:0001057)2.08409011
49Medulloblastoma (HP:0002885)2.07746002
50Absent thumb (HP:0009777)2.07698403
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.06647285
52Congenital, generalized hypertrichosis (HP:0004540)2.04260700
53Abnormal number of erythroid precursors (HP:0012131)2.03582939
54Medial flaring of the eyebrow (HP:0010747)2.02011787
55Abnormal lung lobation (HP:0002101)2.01878763
56Oral leukoplakia (HP:0002745)2.01677729
57Duplicated collecting system (HP:0000081)2.00906107
58Renal Fanconi syndrome (HP:0001994)1.98865831
59Septo-optic dysplasia (HP:0100842)1.98488470
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98272002
61Supernumerary bones of the axial skeleton (HP:0009144)1.98234781
62Premature graying of hair (HP:0002216)1.98193008
63Ectopic kidney (HP:0000086)1.97702620
64Oligodactyly (hands) (HP:0001180)1.97147573
65Increased CSF lactate (HP:0002490)1.96852916
66Pendular nystagmus (HP:0012043)1.95172286
67Pallor (HP:0000980)1.94414738
68Lipid accumulation in hepatocytes (HP:0006561)1.94162726
69Proximal placement of thumb (HP:0009623)1.93202238
70Duodenal stenosis (HP:0100867)1.93026745
71Small intestinal stenosis (HP:0012848)1.93026745
72Bifid tongue (HP:0010297)1.92270921
73Small hand (HP:0200055)1.91887114
74Asplenia (HP:0001746)1.91723979
75Rectal fistula (HP:0100590)1.91721780
76Rectovaginal fistula (HP:0000143)1.91721780
77Pancreatic islet-cell hyperplasia (HP:0004510)1.91356923
78Leukodystrophy (HP:0002415)1.90959885
79Hyperinsulinemic hypoglycemia (HP:0000825)1.89457812
80Abnormality of the renal collecting system (HP:0004742)1.89229011
81Hepatoblastoma (HP:0002884)1.89180377
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.87549223
83Abnormal trabecular bone morphology (HP:0100671)1.86273821
84Aplasia/Hypoplasia of the sternum (HP:0006714)1.85692415
85Agnosia (HP:0010524)1.85522419
86Pancreatic cysts (HP:0001737)1.85437103
87Abnormality of methionine metabolism (HP:0010901)1.85362226
88Abnormality of the incisor (HP:0000676)1.85305759
89Pancreatic fibrosis (HP:0100732)1.84254469
90Genital tract atresia (HP:0001827)1.84238936
91Abnormality of the septum pellucidum (HP:0007375)1.83251165
92Abnormality of the renal medulla (HP:0100957)1.82980404
93Facial cleft (HP:0002006)1.81343888
94Acute encephalopathy (HP:0006846)1.80365289
95Aplasia/Hypoplasia of the earlobes (HP:0009906)1.80331443
96Abdominal situs inversus (HP:0003363)1.80311224
97Abnormality of abdominal situs (HP:0011620)1.80311224
98Deviation of the thumb (HP:0009603)1.79823325
99Hepatocellular necrosis (HP:0001404)1.79532585
100Sclerocornea (HP:0000647)1.79508496
101Sparse lateral eyebrow (HP:0005338)1.79272266
102Methylmalonic aciduria (HP:0012120)1.78839133
103Septate vagina (HP:0001153)1.78776512
104Adrenal hypoplasia (HP:0000835)1.78215248
105Hypoglycemic coma (HP:0001325)1.77786011
106Megaloblastic anemia (HP:0001889)1.77250241
107Intestinal atresia (HP:0011100)1.77100405
108Glossoptosis (HP:0000162)1.76950286
109Multiple enchondromatosis (HP:0005701)1.76601547
110Supernumerary ribs (HP:0005815)1.76153841
111Myelodysplasia (HP:0002863)1.75033513
112Impulsivity (HP:0100710)1.74785313
113Congenital primary aphakia (HP:0007707)1.74632592
114Preaxial hand polydactyly (HP:0001177)1.73338268
115Secondary amenorrhea (HP:0000869)1.73321042
116Abnormality of the duodenum (HP:0002246)1.72424282
117Rhabdomyosarcoma (HP:0002859)1.72281127
118Abnormality of serum amino acid levels (HP:0003112)1.72239866
119Abnormality of renal resorption (HP:0011038)1.72068134
120Oligodactyly (HP:0012165)1.71431297
121Aplasia/Hypoplasia of the spleen (HP:0010451)1.70802143
122Hypoglycemic seizures (HP:0002173)1.70630359
123Anophthalmia (HP:0000528)1.70356881
124Atresia of the external auditory canal (HP:0000413)1.70229071
125Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.70057972
126Aplastic anemia (HP:0001915)1.69613883
127Short thumb (HP:0009778)1.69563018
128Hepatic necrosis (HP:0002605)1.69494106
129Cupped ear (HP:0000378)1.69400906
130Vaginal atresia (HP:0000148)1.68810704
131Gait imbalance (HP:0002141)1.67849072
132Increased serum lactate (HP:0002151)1.67789010
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.67688100
134Hypoplasia of the pons (HP:0012110)1.66994753
135Sloping forehead (HP:0000340)1.65953233
136Esophageal atresia (HP:0002032)1.65223332
137Abnormality of the renal cortex (HP:0011035)1.65167044
138Rib fusion (HP:0000902)1.64801123
139Hyperglycinuria (HP:0003108)1.63498739
140Abnormality of the carotid arteries (HP:0005344)1.63349184
141Abnormality of the pons (HP:0007361)1.62763971
142Neoplasm of the oral cavity (HP:0100649)1.61737869
143Nephrogenic diabetes insipidus (HP:0009806)1.61574136
144Ependymoma (HP:0002888)1.61190614
145Abnormal hair whorl (HP:0010721)1.61106205
146Optic disc pallor (HP:0000543)1.60143235
1473-Methylglutaconic aciduria (HP:0003535)1.60018546
148Bone marrow hypocellularity (HP:0005528)1.59670963
149Selective tooth agenesis (HP:0001592)1.58329402
150Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.57532406
151Absent septum pellucidum (HP:0001331)1.57289727
152Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.56244359

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.67730020
2WEE13.34933094
3EIF2AK13.20154018
4BUB13.07258460
5SRPK12.97592922
6PNCK2.87771665
7MKNK12.70273851
8MKNK22.63954989
9STK162.60904850
10VRK22.34242234
11PLK32.28398018
12PLK42.20098345
13TSSK62.06188792
14MST41.94363851
15NME11.93977599
16TTK1.93469108
17EIF2AK31.90887123
18PBK1.85704052
19VRK11.85465127
20BRSK21.83636058
21ACVR1B1.77205876
22CDK121.70134901
23TAF11.67498036
24PLK11.60021763
25PLK21.59244491
26TLK11.56912409
27BMPR1B1.53342657
28NME21.51959642
29TRIM281.46711378
30NUAK11.44241115
31STK391.42448383
32BCR1.36154895
33CDK71.34907549
34STK38L1.33986994
35AURKB1.30302264
36MAP4K21.25783334
37AKT31.25434062
38CASK1.24911300
39CHEK21.13378236
40MAP3K41.13110280
41CHEK11.11381202
42ATR1.09345697
43NEK21.07039269
44ZAK1.05550671
45EIF2AK21.05471256
46BRD41.02821945
47AURKA1.02401956
48ATM0.99356509
49CDK30.96883883
50NEK60.95985715
51PASK0.92809806
52CDK80.90924892
53FGFR10.88201531
54CSNK2A20.86542511
55RPS6KB20.85650454
56MELK0.83894555
57CSNK1G30.80957059
58MAPK130.80305489
59STK30.79665071
60CSNK1E0.78589535
61ALK0.77348078
62TESK20.76369818
63EPHA20.72622598
64CDK20.71911583
65CSNK2A10.69554907
66CDK10.68957099
67BRSK10.68889322
68ERBB40.68554078
69GRK10.68430232
70PRKCG0.67936366
71CSNK1G10.67728842
72CLK10.67609045
73GRK70.61013788
74MAP2K70.59530842
75CSNK1A1L0.59088816
76MARK10.58968410
77TGFBR10.58826620
78CCNB10.58570651
79RPS6KA50.55821196
80OXSR10.55455717
81LATS10.55051053
82BMPR20.54637982
83STK40.53760005
84NEK10.52669212
85DYRK30.52591762
86MET0.52543891
87BRAF0.51927000
88STK240.50377212
89WNK30.50235415
90LATS20.49178390
91PAK30.48075863
92PRKACB0.46669777
93CSNK1D0.46376531
94DYRK1A0.45825089
95CSNK1A10.45701275
96MAP3K80.45082480
97PRKCI0.44736894
98PRKDC0.44710880
99PRKCE0.43782949
100YES10.43574305
101INSRR0.43335691
102CDK40.42854825
103CSNK1G20.42364953
104CDK190.41959987
105RPS6KA40.41211548
106STK100.41084435
107FRK0.40506288
108WNK40.40192453
109ADRBK10.37903529
110EPHA40.37867765
111PINK10.37381700
112ADRBK20.36139927
113MAPK140.35881688
114GRK50.35761392
115UHMK10.35648787
116MAP3K90.33987042
117FGR0.32665153
118MAP3K120.32255065
119MAPKAPK50.32190160
120MARK30.31659020
121PAK10.31598751
122TNIK0.30790623
123TEC0.30702425
124GSK3B0.29807283
125ERBB30.29730183
126NLK0.29362985
127PDK20.28368195
128DYRK20.27894693
129MINK10.27512794
130CDK90.26491906

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.07566175
2RNA polymerase_Homo sapiens_hsa030203.93204250
3Ribosome_Homo sapiens_hsa030103.78961360
4Mismatch repair_Homo sapiens_hsa034303.39211024
5Spliceosome_Homo sapiens_hsa030403.25519146
6DNA replication_Homo sapiens_hsa030303.21813179
7Proteasome_Homo sapiens_hsa030503.12211883
8RNA transport_Homo sapiens_hsa030133.03021741
9Homologous recombination_Homo sapiens_hsa034402.92202407
10Nucleotide excision repair_Homo sapiens_hsa034202.66940522
11Basal transcription factors_Homo sapiens_hsa030222.61363938
12Non-homologous end-joining_Homo sapiens_hsa034502.49469806
13Fanconi anemia pathway_Homo sapiens_hsa034602.46508512
14Cell cycle_Homo sapiens_hsa041102.37794792
15RNA degradation_Homo sapiens_hsa030182.28952845
16Oxidative phosphorylation_Homo sapiens_hsa001902.24918522
17Pyrimidine metabolism_Homo sapiens_hsa002402.10518493
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95464952
19Parkinsons disease_Homo sapiens_hsa050121.94631816
20Protein export_Homo sapiens_hsa030601.91331493
21Huntingtons disease_Homo sapiens_hsa050161.83675234
22Base excision repair_Homo sapiens_hsa034101.74657018
23mRNA surveillance pathway_Homo sapiens_hsa030151.71560783
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66966699
25Propanoate metabolism_Homo sapiens_hsa006401.65099227
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54427008
27One carbon pool by folate_Homo sapiens_hsa006701.41930800
28Purine metabolism_Homo sapiens_hsa002301.39807908
29Alzheimers disease_Homo sapiens_hsa050101.38427242
30Selenocompound metabolism_Homo sapiens_hsa004501.27878352
31Oocyte meiosis_Homo sapiens_hsa041141.15935357
32Pyruvate metabolism_Homo sapiens_hsa006201.13541870
33p53 signaling pathway_Homo sapiens_hsa041151.11515330
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03835318
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03463754
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03095414
37Epstein-Barr virus infection_Homo sapiens_hsa051690.98773605
38Folate biosynthesis_Homo sapiens_hsa007900.98341438
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97367993
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96653373
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90482175
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85580058
43Butanoate metabolism_Homo sapiens_hsa006500.80435081
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75138114
45Phototransduction_Homo sapiens_hsa047440.73973708
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73602854
47Cardiac muscle contraction_Homo sapiens_hsa042600.71255762
48Systemic lupus erythematosus_Homo sapiens_hsa053220.71231764
49TGF-beta signaling pathway_Homo sapiens_hsa043500.70895588
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66671659
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.65433961
52Nicotine addiction_Homo sapiens_hsa050330.60786791
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58366146
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56580190
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56314850
56Ether lipid metabolism_Homo sapiens_hsa005650.55905084
57Basal cell carcinoma_Homo sapiens_hsa052170.55765536
58MicroRNAs in cancer_Homo sapiens_hsa052060.55084787
59Serotonergic synapse_Homo sapiens_hsa047260.53444884
60Hippo signaling pathway_Homo sapiens_hsa043900.53363203
61Wnt signaling pathway_Homo sapiens_hsa043100.53265920
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53052928
63Vitamin digestion and absorption_Homo sapiens_hsa049770.53049573
64Linoleic acid metabolism_Homo sapiens_hsa005910.52890980
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51806495
66Hedgehog signaling pathway_Homo sapiens_hsa043400.50442908
67Arachidonic acid metabolism_Homo sapiens_hsa005900.50169107
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49498234
69Nitrogen metabolism_Homo sapiens_hsa009100.49114497
70Viral carcinogenesis_Homo sapiens_hsa052030.48943755
71Peroxisome_Homo sapiens_hsa041460.48286247
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47749987
73Retinol metabolism_Homo sapiens_hsa008300.45669657
74Autoimmune thyroid disease_Homo sapiens_hsa053200.44561961
75Alcoholism_Homo sapiens_hsa050340.43454957
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43150778
77Fatty acid elongation_Homo sapiens_hsa000620.42816201
78HTLV-I infection_Homo sapiens_hsa051660.42153280
79Caffeine metabolism_Homo sapiens_hsa002320.42070166
80Fatty acid degradation_Homo sapiens_hsa000710.41755840
81Fatty acid metabolism_Homo sapiens_hsa012120.41600540
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.40650112
83Regulation of autophagy_Homo sapiens_hsa041400.40405933
84Herpes simplex infection_Homo sapiens_hsa051680.38645355
85Graft-versus-host disease_Homo sapiens_hsa053320.38307936
86Long-term depression_Homo sapiens_hsa047300.38004114
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37660907
88Thyroid cancer_Homo sapiens_hsa052160.37503000
89Allograft rejection_Homo sapiens_hsa053300.35447155
90Circadian rhythm_Homo sapiens_hsa047100.35345473
91Tryptophan metabolism_Homo sapiens_hsa003800.35116061
92Olfactory transduction_Homo sapiens_hsa047400.34969067
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34956617
94Tight junction_Homo sapiens_hsa045300.34853305
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34366337
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34339950
97beta-Alanine metabolism_Homo sapiens_hsa004100.33718230
98Vibrio cholerae infection_Homo sapiens_hsa051100.33582580
99Antigen processing and presentation_Homo sapiens_hsa046120.33516438
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32279385
101Steroid biosynthesis_Homo sapiens_hsa001000.32211763
102Carbon metabolism_Homo sapiens_hsa012000.31760362
103Chemical carcinogenesis_Homo sapiens_hsa052040.31570616
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31537708
105Vitamin B6 metabolism_Homo sapiens_hsa007500.30459978
106ECM-receptor interaction_Homo sapiens_hsa045120.30094738
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.29824643
108Biosynthesis of amino acids_Homo sapiens_hsa012300.29763792
109Sphingolipid metabolism_Homo sapiens_hsa006000.29465107
110Axon guidance_Homo sapiens_hsa043600.29245185
111Pathways in cancer_Homo sapiens_hsa052000.29195032
112Collecting duct acid secretion_Homo sapiens_hsa049660.29165962
113Prostate cancer_Homo sapiens_hsa052150.28720999
114Amphetamine addiction_Homo sapiens_hsa050310.28593812
115Lysine degradation_Homo sapiens_hsa003100.27559802
116Type I diabetes mellitus_Homo sapiens_hsa049400.27106200
117Melanoma_Homo sapiens_hsa052180.27080466
118Asthma_Homo sapiens_hsa053100.25273791
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25118229
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24785728
121Metabolic pathways_Homo sapiens_hsa011000.24382923
122Long-term potentiation_Homo sapiens_hsa047200.23792455
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23738381
124Glutathione metabolism_Homo sapiens_hsa004800.22850820
125Arginine and proline metabolism_Homo sapiens_hsa003300.22615123
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22012328
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21563102
128Fatty acid biosynthesis_Homo sapiens_hsa000610.21424472
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20965220
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20465280
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19933200
132Adherens junction_Homo sapiens_hsa045200.19695639
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.17768125
134N-Glycan biosynthesis_Homo sapiens_hsa005100.17057340
135Small cell lung cancer_Homo sapiens_hsa052220.16844965
136Taste transduction_Homo sapiens_hsa047420.16672018
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16199976
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15578633
139Melanogenesis_Homo sapiens_hsa049160.15308898
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.15071476
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14272302
142Hematopoietic cell lineage_Homo sapiens_hsa046400.12975694
143Dopaminergic synapse_Homo sapiens_hsa047280.12218917
144Glutamatergic synapse_Homo sapiens_hsa047240.11791446
145Rheumatoid arthritis_Homo sapiens_hsa053230.11214259
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11015223
147African trypanosomiasis_Homo sapiens_hsa051430.10320979
148Ras signaling pathway_Homo sapiens_hsa040140.09849832

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