ESM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Notch signaling involved in heart development (GO:0061314)9.52183498
2vascular endothelial growth factor signaling pathway (GO:0038084)8.97083838
3ventricular trabecula myocardium morphogenesis (GO:0003222)8.86341960
4negative regulation of blood vessel endothelial cell migration (GO:0043537)8.86055348
5heart trabecula morphogenesis (GO:0061384)7.73076127
6lymph vessel development (GO:0001945)7.38744395
7trabecula morphogenesis (GO:0061383)7.20181912
8angiogenesis involved in wound healing (GO:0060055)7.17331675
9retina vasculature morphogenesis in camera-type eye (GO:0061299)6.44992258
10regulation of cell migration involved in sprouting angiogenesis (GO:0090049)6.17351562
11surfactant homeostasis (GO:0043129)5.77517657
12cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.67474183
13lymphangiogenesis (GO:0001946)5.42139196
14heart valve formation (GO:0003188)5.39467879
15vascular endothelial growth factor receptor signaling pathway (GO:0048010)5.38227512
16wound healing, spreading of epidermal cells (GO:0035313)5.36620719
17regulation of blood vessel endothelial cell migration (GO:0043535)5.34567908
18basement membrane organization (GO:0071711)5.32999010
19coronary vasculature morphogenesis (GO:0060977)5.31666419
20cell migration involved in sprouting angiogenesis (GO:0002042)5.08913366
21ganglion development (GO:0061548)5.08776831
22endothelium development (GO:0003158)4.91012835
23endothelial cell morphogenesis (GO:0001886)4.79464760
24protein kinase C signaling (GO:0070528)4.60600663
25positive regulation of odontogenesis (GO:0042482)4.55187165
26negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.54246985
27labyrinthine layer development (GO:0060711)4.54235962
28patterning of blood vessels (GO:0001569)4.51001894
29venous blood vessel morphogenesis (GO:0048845)4.48165416
30positive regulation of endothelial cell differentiation (GO:0045603)4.36123605
31regulation of axon extension involved in axon guidance (GO:0048841)4.33988593
32chemical homeostasis within a tissue (GO:0048875)4.33758091
33cell surface receptor signaling pathway involved in heart development (GO:0061311)4.32933421
34axon extension involved in axon guidance (GO:0048846)4.22686878
35neuron projection extension involved in neuron projection guidance (GO:1902284)4.22686878
36substrate-dependent cell migration (GO:0006929)4.13171926
37regulation of cellular extravasation (GO:0002691)4.06790745
38endothelial cell chemotaxis (GO:0035767)4.06552278
39aorta morphogenesis (GO:0035909)4.04095656
40positive regulation of vasculogenesis (GO:2001214)4.03009103
41peptidyl-tyrosine autophosphorylation (GO:0038083)4.00237050
42endocardial cushion morphogenesis (GO:0003203)4.00041475
43negative regulation of angiogenesis (GO:0016525)3.99965024
44blood vessel endothelial cell migration (GO:0043534)3.95898928
45thrombin receptor signaling pathway (GO:0070493)3.95054170
46* angiogenesis (GO:0001525)3.90506994
47positive regulation of focal adhesion assembly (GO:0051894)3.88789131
48positive regulation of cell junction assembly (GO:1901890)3.88789131
49negative regulation of blood vessel morphogenesis (GO:2000181)3.85961164
50Notch receptor processing (GO:0007220)3.84701920
51* sprouting angiogenesis (GO:0002040)3.84575421
52heart trabecula formation (GO:0060347)3.82768249
53positive regulation of smooth muscle cell migration (GO:0014911)3.80259951
54Golgi transport vesicle coating (GO:0048200)3.75564008
55COPI coating of Golgi vesicle (GO:0048205)3.75564008
56epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.75365066
57renal tubule morphogenesis (GO:0061333)3.74854728
58protein localization to endosome (GO:0036010)3.72970760
59positive regulation of Rap GTPase activity (GO:0032854)3.71031914
60negative regulation of focal adhesion assembly (GO:0051895)3.71011950
61negative regulation of cell junction assembly (GO:1901889)3.71011950
62negative regulation of adherens junction organization (GO:1903392)3.71011950
63regulation of axon guidance (GO:1902667)3.67757541
64positive regulation of adherens junction organization (GO:1903393)3.67246903
65negative regulation of vasculature development (GO:1901343)3.66367554
66endothelial cell differentiation (GO:0045446)3.61784654
67negative regulation of Rho protein signal transduction (GO:0035024)3.57240588
68establishment of endothelial barrier (GO:0061028)3.52454283
69cell adhesion mediated by integrin (GO:0033627)3.50875075
70hyaluronan catabolic process (GO:0030214)3.48791424
71regulation of vasculogenesis (GO:2001212)3.46525026
72wound healing, spreading of cells (GO:0044319)3.44761579
73response to hepatocyte growth factor (GO:0035728)3.42073114
74cellular response to hepatocyte growth factor stimulus (GO:0035729)3.42073114
75glomerular filtration (GO:0003094)3.39820048
76transcytosis (GO:0045056)3.39696153
77exocrine pancreas development (GO:0031017)3.39079782
78endothelial cell proliferation (GO:0001935)3.37912067
79regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.37069587
80endodermal cell differentiation (GO:0035987)3.32566170
81cellular response to vitamin D (GO:0071305)3.32466704
82protein maturation by protein folding (GO:0022417)3.32463076
83blood vessel maturation (GO:0001955)3.29023235
84regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.27526570
85regulation of epithelial cell migration (GO:0010632)3.26378982
86neuron remodeling (GO:0016322)3.23957469
87renal filtration (GO:0097205)3.23897513
88chondrocyte proliferation (GO:0035988)3.18553175
89regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.18475715
90germ cell migration (GO:0008354)3.13744012
91type B pancreatic cell development (GO:0003323)3.12480263
92artery development (GO:0060840)3.11289436
93regulation of Rap GTPase activity (GO:0032317)3.07716412
94cardiac ventricle morphogenesis (GO:0003208)3.06609181
95semaphorin-plexin signaling pathway (GO:0071526)3.03334848
96positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.01913788
97regulation of endothelial cell differentiation (GO:0045601)3.01703859
98endothelial cell migration (GO:0043542)2.98367287
99plasma membrane fusion (GO:0045026)2.97460250
100intestinal epithelial cell development (GO:0060576)2.97070917
101positive regulation of urine volume (GO:0035810)2.96626084
102platelet-derived growth factor receptor signaling pathway (GO:0048008)2.96128931
103positive regulation of epithelial cell migration (GO:0010634)2.88861398
104negative regulation of cell-substrate adhesion (GO:0010812)2.87303137
105glandular epithelial cell development (GO:0002068)2.86994561
106regulation of endothelial cell chemotaxis (GO:2001026)2.84647415
107positive regulation of histone deacetylation (GO:0031065)2.83716649
108regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.82880061
109cardiac chamber morphogenesis (GO:0003206)2.80209836
110positive regulation of calcium ion import (GO:0090280)2.78182722
111mesenchyme morphogenesis (GO:0072132)2.76497922
112positive regulation of endothelial cell migration (GO:0010595)2.76207239
113cardiac epithelial to mesenchymal transition (GO:0060317)2.74076106
114negative regulation of axon extension involved in axon guidance (GO:0048843)2.71567556
115regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70155088
116regulation of vasculature development (GO:1901342)2.69846247
117negative regulation of catenin import into nucleus (GO:0035414)2.67461582
118regulation of positive chemotaxis (GO:0050926)2.64561919
119columnar/cuboidal epithelial cell development (GO:0002066)2.63205029
120positive regulation of hormone biosynthetic process (GO:0046886)2.62630201
121endothelial cell development (GO:0001885)2.62565088
122positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.59944581
123hippo signaling (GO:0035329)2.58984918
124positive regulation of positive chemotaxis (GO:0050927)2.56292695
125blood vessel morphogenesis (GO:0048514)2.54439679
126regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.53986167
127regulation of endothelial cell migration (GO:0010594)2.52889066
128positive regulation of endothelial cell proliferation (GO:0001938)2.52729432
129regulation of focal adhesion assembly (GO:0051893)2.52393636
130regulation of cell-substrate junction assembly (GO:0090109)2.52393636
131endothelial tube morphogenesis (GO:0061154)2.50501653
132morphogenesis of an endothelium (GO:0003159)2.50501653
133dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.49589290
134cellular response to vitamin (GO:0071295)2.49139132
135negative regulation of endothelial cell migration (GO:0010596)2.45804978
136regulation of establishment or maintenance of cell polarity (GO:0032878)2.45752607
137regulation of adherens junction organization (GO:1903391)2.45017776
138negative regulation of endothelial cell apoptotic process (GO:2000352)2.44660781
139negative regulation of bone resorption (GO:0045779)2.44468002
140blood vessel remodeling (GO:0001974)2.42034851
141positive regulation of Rho protein signal transduction (GO:0035025)2.41185365
142lung vasculature development (GO:0060426)2.41082545
143positive regulation of p38MAPK cascade (GO:1900745)2.40648089
144positive regulation of axon extension (GO:0045773)2.40051227
145regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.39783849
146regulation of establishment of cell polarity (GO:2000114)2.38549545
147negative regulation of epithelial cell migration (GO:0010633)2.37248114
148vasculogenesis (GO:0001570)2.36708830
149negative regulation of keratinocyte proliferation (GO:0010839)2.35436093
150chondrocyte development (GO:0002063)2.32918479
151embryonic heart tube development (GO:0035050)2.32568060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.28619396
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.34477589
3ELK3_25401928_ChIP-Seq_HUVEC_Human3.20676943
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.19185843
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.83134069
6GATA2_21666600_ChIP-Seq_HMVEC_Human2.46288174
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.32673130
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.30102425
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.28872647
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25111564
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.20696659
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.14157949
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10408301
14CLOCK_20551151_ChIP-Seq_293T_Human2.07497733
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07205431
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91745994
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.87425421
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83485925
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.78710883
20HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74447911
21GATA1_22025678_ChIP-Seq_K562_Human1.70007180
22CJUN_26792858_Chip-Seq_BT549_Human1.68452023
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66984070
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65291323
25CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.62057421
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.61501629
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.59879411
28SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.59467140
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56470511
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56470511
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.56090606
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.56090606
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55900828
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53132346
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51547301
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50874556
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49658036
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49658036
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.48125689
40AHR_22903824_ChIP-Seq_MCF-7_Human1.47577280
41* BRD4_25478319_ChIP-Seq_HGPS_Human1.40159287
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39463110
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36533900
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35972259
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.33554924
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33296785
47TCF4_18268006_ChIP-ChIP_LS174T_Human1.30522964
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.30243945
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.29963476
50TP53_16413492_ChIP-PET_HCT116_Human1.29728617
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28351331
52SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27757708
53UBF1/2_26484160_Chip-Seq_HMECs_Human1.27118128
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26674762
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.26382635
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25427765
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22585642
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22341310
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22276172
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21751779
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20955830
62VDR_24787735_ChIP-Seq_THP-1_Human1.19853661
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19769984
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19521211
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19244216
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18161741
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18130187
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15591797
69SOX2_20726797_ChIP-Seq_SW620_Human1.15279206
70JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14446373
71* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13584185
72MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13556584
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12365465
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11794493
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09172590
76TP63_23658742_ChIP-Seq_EP156T_Human1.08674403
77TP53_18474530_ChIP-ChIP_U2OS_Human1.08443924
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08419724
79* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08133404
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.07118926
81TBX20_22080862_ChIP-Seq_HEART_Mouse1.07118926
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06849036
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06340287
84TAF15_26573619_Chip-Seq_HEK293_Human1.04702091
85TP53_22127205_ChIP-Seq_IMR90_Human1.04195333
86BCAT_22108803_ChIP-Seq_LS180_Human1.03841167
87RUNX_20019798_ChIP-Seq_JUKART_Human1.02851219
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02799548
89SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01821624
90RXR_22108803_ChIP-Seq_LS180_Human1.01308585
91GATA1_19941826_ChIP-Seq_K562_Human1.00518639
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00399637
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00203084
94FOXA2_19822575_ChIP-Seq_HepG2_Human1.00091831
95ISL1_27105846_Chip-Seq_CPCs_Mouse0.99609520
96FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99333909
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99240255
98SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98996729
99MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98200212
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.98194495
101SMAD4_21799915_ChIP-Seq_A2780_Human0.98138516
102SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98097369
103SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97406199
104SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97403646
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97308287
106SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97121604
107PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96076279
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95922561
109TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95521118
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94760464
111P300_19829295_ChIP-Seq_ESCs_Human0.94286468
112EED_16625203_ChIP-ChIP_MESCs_Mouse0.93305910
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92904550
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92116141
115TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91731888
116GBX2_23144817_ChIP-Seq_PC3_Human0.91547676
117FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91465696
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.91299537
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91150890
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91150890
121KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91150890
122SCL_19346495_ChIP-Seq_HPC-7_Human0.90964942
123* SMAD3_21741376_ChIP-Seq_EPCs_Human0.90411535
124MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90381568
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89766410
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.87477775
127STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87197188
128LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86969694
129FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86864382
130* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86490994
131VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86331056
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86204373
133Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86173471
134TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86123925
135STAT3_23295773_ChIP-Seq_U87_Human0.85724567
136SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85622314
137SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85194693
138LXR_22158963_ChIP-Seq_LIVER_Mouse0.85108964
139DROSHA_22980978_ChIP-Seq_HELA_Human0.84493409
140SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84252426
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82045146
142SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81856301
143KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81650650
144TET1_21490601_ChIP-Seq_MESCs_Mouse0.81070310
145NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79208339
146UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78486706
147RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.77135643
148SPI1_23127762_ChIP-Seq_K562_Human0.76723604
149TP53_23651856_ChIP-Seq_MEFs_Mouse0.75417853
150GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.74905556
151SOX11_22085726_ChIP-Seq_ESNs_Mouse0.73420211
152* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.72683062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.14678052
2MP0004272_abnormal_basement_membrane6.49697043
3MP0001879_abnormal_lymphatic_vessel5.94665095
4MP0000465_gastrointestinal_hemorrhage3.09200072
5MP0003828_pulmonary_edema3.02575442
6MP0003724_increased_susceptibility_to2.69248527
7MP0000013_abnormal_adipose_tissue2.37422418
8MP0003300_gastrointestinal_ulcer2.32739235
9MP0010234_abnormal_vibrissa_follicle2.27206643
10MP0002877_abnormal_melanocyte_morpholog2.19814414
11MP0004084_abnormal_cardiac_muscle2.19330072
12MP0006054_spinal_hemorrhage2.18989223
13MP0005165_increased_susceptibility_to2.17203400
14MP0003566_abnormal_cell_adhesion2.09102674
15MP0009780_abnormal_chondrocyte_physiolo2.07965338
16MP0010352_gastrointestinal_tract_polyps2.00105058
17MP0005167_abnormal_blood-brain_barrier1.97957188
18MP0003279_aneurysm1.83194227
19MP0003705_abnormal_hypodermis_morpholog1.78116436
20MP0002009_preneoplasia1.69824040
21MP0004510_myositis1.68804415
22MP0000767_abnormal_smooth_muscle1.68611739
23MP0003252_abnormal_bile_duct1.62131089
24MP0003045_fibrosis1.57900476
25MP0005187_abnormal_penis_morphology1.50402278
26MP0000751_myopathy1.48492508
27MP0005367_renal/urinary_system_phenotyp1.48337795
28MP0000516_abnormal_urinary_system1.48337795
29MP0002896_abnormal_bone_mineralization1.45981122
30MP0002925_abnormal_cardiovascular_devel1.41113298
31MP0003890_abnormal_embryonic-extraembry1.39210929
32MP0001944_abnormal_pancreas_morphology1.38868852
33MP0005623_abnormal_meninges_morphology1.37522407
34MP0004782_abnormal_surfactant_physiolog1.37155783
35MP0009053_abnormal_anal_canal1.35243536
36MP0001958_emphysema1.34239531
37MP0003283_abnormal_digestive_organ1.33408211
38MP0002128_abnormal_blood_circulation1.26852157
39MP0003091_abnormal_cell_migration1.25236203
40MP0001849_ear_inflammation1.24588539
41MP0008775_abnormal_heart_ventricle1.21665880
42MP0002166_altered_tumor_susceptibility1.19942705
43MP0005595_abnormal_vascular_smooth1.19245732
44MP0002006_tumorigenesis1.18741017
45MP0006138_congestive_heart_failure1.17908299
46MP0004036_abnormal_muscle_relaxation1.17124998
47MP0008438_abnormal_cutaneous_collagen1.16804387
48MP0001614_abnormal_blood_vessel1.16503157
49MP0002909_abnormal_adrenal_gland1.15542749
50MP0002933_joint_inflammation1.12996319
51MP0002693_abnormal_pancreas_physiology1.12980713
52MP0003984_embryonic_growth_retardation1.12613922
53MP0000537_abnormal_urethra_morphology1.10298899
54MP0002088_abnormal_embryonic_growth/wei1.09628436
55MP0002928_abnormal_bile_duct1.09615784
56MP0000733_abnormal_muscle_development1.08857229
57MP0004484_altered_response_of1.08813442
58MP0001756_abnormal_urination1.08408851
59MP0000678_abnormal_parathyroid_gland1.07083751
60MP0000003_abnormal_adipose_tissue1.06455851
61MP0002234_abnormal_pharynx_morphology1.05439033
62MP0002697_abnormal_eye_size1.03078503
63MP0003943_abnormal_hepatobiliary_system1.02641772
64MP0005084_abnormal_gallbladder_morpholo1.01484541
65MP0005197_abnormal_uvea_morphology1.00478642
66MP0005409_darkened_coat_color0.98361360
67MP0003935_abnormal_craniofacial_develop0.97732283
68MP0005164_abnormal_response_to0.97619883
69MP0002127_abnormal_cardiovascular_syste0.96211907
70MP0002138_abnormal_hepatobiliary_system0.95809933
71MP0002332_abnormal_exercise_endurance0.94065180
72MP0000534_abnormal_ureter_morphology0.90886805
73MP0005365_abnormal_bile_salt0.89922164
74MP0004043_abnormal_pH_regulation0.89257539
75MP0000230_abnormal_systemic_arterial0.89042857
76MP0001672_abnormal_embryogenesis/_devel0.88618163
77MP0005380_embryogenesis_phenotype0.88618163
78MP0000249_abnormal_blood_vessel0.88332716
79MP0004085_abnormal_heartbeat0.88077937
80MP0002092_abnormal_eye_morphology0.87524210
81MP0001784_abnormal_fluid_regulation0.86874177
82MP0005193_abnormal_anterior_eye0.85720561
83MP0005464_abnormal_platelet_physiology0.84824337
84MP0002086_abnormal_extraembryonic_tissu0.83857357
85MP0001915_intracranial_hemorrhage0.83059290
86MP0003303_peritoneal_inflammation0.82028945
87MP0002295_abnormal_pulmonary_circulatio0.81615805
88MP0005220_abnormal_exocrine_pancreas0.81410973
89MP0004883_abnormal_blood_vessel0.80803490
90MP0001270_distended_abdomen0.77804871
91MP0010030_abnormal_orbit_morphology0.77738734
92MP0003868_abnormal_feces_composition0.76770962
93MP0004808_abnormal_hematopoietic_stem0.76733660
94MP0000266_abnormal_heart_morphology0.76404922
95MP0004264_abnormal_extraembryonic_tissu0.75582862
96MP0002168_other_aberrant_phenotype0.75499697
97MP0010630_abnormal_cardiac_muscle0.75460321
98MP0003195_calcinosis0.73074404
99MP0004233_abnormal_muscle_weight0.72995655
100MP0005379_endocrine/exocrine_gland_phen0.72011843
101MP0009643_abnormal_urine_homeostasis0.71698211
102MP0005076_abnormal_cell_differentiation0.69360509
103MP0002108_abnormal_muscle_morphology0.68043297
104MP0002133_abnormal_respiratory_system0.67839064
105MP0005388_respiratory_system_phenotype0.67839064
106MP0002972_abnormal_cardiac_muscle0.67671300
107MP0003183_abnormal_peptide_metabolism0.67374915
108MP0001544_abnormal_cardiovascular_syste0.66658246
109MP0005385_cardiovascular_system_phenoty0.66658246
110MP0003448_altered_tumor_morphology0.66300125
111MP0005248_abnormal_Harderian_gland0.65225682
112MP0010678_abnormal_skin_adnexa0.64917456
113MP0005508_abnormal_skeleton_morphology0.64398408
114MP0005023_abnormal_wound_healing0.64097542
115MP0005620_abnormal_muscle_contractility0.64040291
116MP0003950_abnormal_plasma_membrane0.63384303
117MP0004145_abnormal_muscle_electrophysio0.62742855
118MP0005330_cardiomyopathy0.60856141
119MP0003119_abnormal_digestive_system0.60522767
120MP0004215_abnormal_myocardial_fiber0.58415781
121MP0001191_abnormal_skin_condition0.55512633
122MP0005501_abnormal_skin_physiology0.51834810
123MP0000467_abnormal_esophagus_morphology0.49812311
124MP0003385_abnormal_body_wall0.49307220
125MP0002084_abnormal_developmental_patter0.49194784
126MP0000747_muscle_weakness0.48149156
127MP0000343_altered_response_to0.47882488
128MP0009697_abnormal_copulation0.47779572
129MP0008260_abnormal_autophagy0.46781941
130MP0003941_abnormal_skin_development0.46457437
131MP0002796_impaired_skin_barrier0.44699190
132MP0000049_abnormal_middle_ear0.43960137
133MP0002080_prenatal_lethality0.40549081
134MP0001293_anophthalmia0.39672302
135MP0001243_abnormal_dermal_layer0.39322725
136MP0004858_abnormal_nervous_system0.39059082
137MP0001730_embryonic_growth_arrest0.38926972
138MP0009840_abnormal_foam_cell0.36261673

Predicted human phenotypes

RankGene SetZ-score
1Limb dystonia (HP:0002451)5.83225090
2Amblyopia (HP:0000646)4.72582330
3Esophageal varix (HP:0002040)4.61291416
4Adactyly (HP:0009776)4.58916421
5Scotoma (HP:0000575)4.37368675
6Cerebral hemorrhage (HP:0001342)4.22700266
7Hematochezia (HP:0002573)4.17388061
8Hyperinsulinemic hypoglycemia (HP:0000825)4.16661074
9Hypoglycemic seizures (HP:0002173)4.02312603
10Polycythemia (HP:0001901)4.00045146
11Cerebral aneurysm (HP:0004944)3.85538736
12Porencephaly (HP:0002132)3.84460833
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.76873133
14Wrist flexion contracture (HP:0001239)3.76550737
15Lymphangioma (HP:0100764)3.63451261
16Hemiparesis (HP:0001269)3.62691186
17Skull defect (HP:0001362)3.61599185
18Absent hand (HP:0004050)3.54291472
19Hypopigmentation of the fundus (HP:0007894)3.49250718
20Hypoglycemic coma (HP:0001325)3.34718159
21Difficulty climbing stairs (HP:0003551)3.28800686
22Symptomatic seizures (HP:0011145)3.28114284
23Thoracolumbar scoliosis (HP:0002944)3.09343515
24Protrusio acetabuli (HP:0003179)3.06856341
25Cutis marmorata (HP:0000965)3.01594919
26Portal hypertension (HP:0001409)2.98116981
27Aortic aneurysm (HP:0004942)2.96992065
28Submucous cleft hard palate (HP:0000176)2.95745504
29Abnormality of the right ventricle (HP:0001707)2.91240623
30Pancreatic islet-cell hyperplasia (HP:0004510)2.82305228
31Congenital cataract (HP:0000519)2.80175565
32Nonimmune hydrops fetalis (HP:0001790)2.79762268
33Spinal rigidity (HP:0003306)2.79487326
34Insulin-resistant diabetes mellitus (HP:0000831)2.76746818
35Growth hormone excess (HP:0000845)2.76143621
36Aneurysm (HP:0002617)2.73198080
37Rectal prolapse (HP:0002035)2.68717447
38Broad metatarsal (HP:0001783)2.66795924
39Hyperglycemia (HP:0003074)2.66573785
40Abnormality of the hepatic vasculature (HP:0006707)2.65776390
41Myocardial infarction (HP:0001658)2.65172449
42Large for gestational age (HP:0001520)2.61091044
43Abnormal vertebral ossification (HP:0100569)2.59445715
44Abnormality of the nasal mucosa (HP:0000433)2.58915838
45Papilledema (HP:0001085)2.57023800
46Abnormality of the vitreous humor (HP:0004327)2.56919975
47Pulmonic stenosis (HP:0001642)2.55477424
48Aortic dissection (HP:0002647)2.54604207
49Stenosis of the external auditory canal (HP:0000402)2.53534892
50Menorrhagia (HP:0000132)2.53170894
51Ketoacidosis (HP:0001993)2.52496851
52Hemorrhage of the eye (HP:0011885)2.52483712
53Subacute progressive viral hepatitis (HP:0006572)2.48595806
54Spontaneous hematomas (HP:0007420)2.48454665
55Enlarged penis (HP:0000040)2.47307230
56Vertebral clefting (HP:0008428)2.47275214
57Macroorchidism (HP:0000053)2.46916371
58Abnormality of the vasculature of the conjunctiva (HP:0008054)2.45886017
59Hemiplegia (HP:0002301)2.38417224
60Abnormality of the ischium (HP:0003174)2.38243065
61Limb-girdle muscle atrophy (HP:0003797)2.32753703
62Increased mean platelet volume (HP:0011877)2.27507162
63Abnormality of endocrine pancreas physiology (HP:0012093)2.27373557
64Abnormality of the pancreatic islet cells (HP:0006476)2.27373557
65Impaired platelet aggregation (HP:0003540)2.26221131
66Abnormal platelet function (HP:0011869)2.26221131
67Venous insufficiency (HP:0005293)2.23524680
68Absent eyebrow (HP:0002223)2.22934887
69Myotonia (HP:0002486)2.22593882
70Bilateral sensorineural hearing impairment (HP:0008619)2.22361450
71Abnormality of calcium-phosphate metabolism (HP:0100530)2.22184420
72Hypoplastic ischia (HP:0003175)2.18580511
73Premature rupture of membranes (HP:0001788)2.17552810
74Abnormality of skeletal muscle fiber size (HP:0012084)2.12337291
75Overgrowth (HP:0001548)2.11972799
76Atrophic scars (HP:0001075)2.11866176
77Hypoplasia of the iris (HP:0007676)2.11771155
78Absent toe (HP:0010760)2.09137209
79Cortical dysplasia (HP:0002539)2.07788157
80Supraventricular arrhythmia (HP:0005115)2.05998983
81Volvulus (HP:0002580)2.05433065
82Tetraparesis (HP:0002273)2.02452311
83Distal lower limb muscle weakness (HP:0009053)2.02435397
84Coxa vara (HP:0002812)2.01267278
85Urinary glycosaminoglycan excretion (HP:0003541)2.01193978
86Mucopolysacchariduria (HP:0008155)2.01193978
87Visceral angiomatosis (HP:0100761)2.00891821
88Abnormal platelet volume (HP:0011876)1.99879760
89Back pain (HP:0003418)1.99294712
90Capillary hemangiomas (HP:0005306)1.98623308
91Cerebral ischemia (HP:0002637)1.98252037
92Abnormality of the nasal septum (HP:0000419)1.97082202
93Arterial tortuosity (HP:0005116)1.95994231
94Muscle fiber splitting (HP:0003555)1.95613922
95Hyporeflexia of lower limbs (HP:0002600)1.95598178
96Pulmonary hypertension (HP:0002092)1.90583456
97Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90315538
98Hemangiomatosis (HP:0007461)1.90205562
99Mitral stenosis (HP:0001718)1.88822103
100Bone cyst (HP:0012062)1.87754187
101Conjunctival telangiectasia (HP:0000524)1.87689892
102Ectopia lentis (HP:0001083)1.86214463
103Venous abnormality (HP:0002624)1.85291582
104Pulmonary artery stenosis (HP:0004415)1.85030267
105Short hallux (HP:0010109)1.84765957
106Chondrocalcinosis (HP:0000934)1.83948937
107Wormian bones (HP:0002645)1.83553641
108Shallow orbits (HP:0000586)1.82073469
109Asymmetry of the thorax (HP:0001555)1.82047291
110Neonatal death (HP:0003811)1.81885578
111Lumbar hyperlordosis (HP:0002938)1.81551290
112Difficulty running (HP:0009046)1.79909560
113Distal lower limb amyotrophy (HP:0008944)1.79628119
114Increased variability in muscle fiber diameter (HP:0003557)1.79166242
115Hematuria (HP:0000790)1.79046804
116Vascular tortuosity (HP:0004948)1.78487211
117High pitched voice (HP:0001620)1.78389187
118Retinal detachment (HP:0000541)1.77501710
119Neoplasm of the lung (HP:0100526)1.76947557
120Full cheeks (HP:0000293)1.75569713
121Cervical subluxation (HP:0003308)1.73476495
122Blue sclerae (HP:0000592)1.73176410
123Lymphedema (HP:0001004)1.72843496
124Congenital, generalized hypertrichosis (HP:0004540)1.72401451
125Keratoconus (HP:0000563)1.71538177
126Increased corneal curvature (HP:0100692)1.71538177
127Buphthalmos (HP:0000557)1.71478730
128Abnormality of Sharpey fibers (HP:0100685)1.71130145
129Cavernous hemangioma (HP:0001048)1.70815066
130Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70483187
131Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70483187
132Abnormality of polysaccharide metabolism (HP:0011012)1.70483187
133Transitional cell carcinoma of the bladder (HP:0006740)1.68854736
134Increased connective tissue (HP:0009025)1.68676473
135Pigmentary retinal degeneration (HP:0001146)1.68469771
136Short 4th metacarpal (HP:0010044)1.68157780
137Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.68157780
138Hypokalemia (HP:0002900)1.68151796
139Insulin resistance (HP:0000855)1.67229882
140Absent eyelashes (HP:0000561)1.67187016
141Limited hip movement (HP:0008800)1.65691530
142Bronchomalacia (HP:0002780)1.65538799
143Reduced subcutaneous adipose tissue (HP:0003758)1.64766429
144Hip contracture (HP:0003273)1.64051390
145Stroke (HP:0001297)1.63738170
146Exotropia (HP:0000577)1.63415412
147Aplasia cutis congenita (HP:0001057)1.63106047
148Abnormality of chloride homeostasis (HP:0011422)1.62209268
149Coarse hair (HP:0002208)1.61366912
150Abnormality of the common coagulation pathway (HP:0010990)1.60432267
151Craniofacial hyperostosis (HP:0004493)1.60052908
152Soft skin (HP:0000977)1.59931817
153Aplasia/Hypoplasia of the hallux (HP:0008362)1.59820260
154Hydroureter (HP:0000072)1.59240250
155Vertebral compression fractures (HP:0002953)1.58567513
156Mask-like facies (HP:0000298)1.57954043
157Trismus (HP:0000211)1.57643679
158Shoulder girdle muscle weakness (HP:0003547)1.56438248
159Disproportionate tall stature (HP:0001519)1.56417493
160Joint stiffness (HP:0001387)1.54869075
161Aortic valve stenosis (HP:0001650)1.53682693
162Abnormality of dentin (HP:0010299)1.53056458
163Flexion contracture of toe (HP:0005830)1.52434424
164Joint contractures involving the joints of the feet (HP:0100492)1.52434424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.89252254
2TIE15.65292354
3INSRR4.47973488
4FRK4.01789022
5TGFBR22.67257317
6EPHB22.53146985
7FGFR32.40661850
8PDGFRA2.27774959
9TGFBR12.27094678
10FGFR21.92764199
11ARAF1.87093961
12RIPK11.85404274
13MAP3K121.75049888
14DMPK1.74672287
15FER1.67008956
16STK101.57007202
17TAOK31.53913257
18MAP3K131.53556714
19MOS1.52830428
20PRKD31.50163801
21LATS11.40678241
22SIK11.39191328
23PRKCH1.33007872
24PDGFRB1.32470781
25LRRK21.32013283
26PTK61.30674854
27TSSK61.23344500
28MAP3K91.21199058
29AKT31.17976172
30TRPM71.12472040
31CSNK1A1L1.11905915
32PTK21.11329759
33FGFR41.07313359
34ERN11.06584976
35SCYL21.05972503
36ZAK1.05763842
37HIPK21.05147629
38ERBB41.01276675
39FGFR10.97358412
40CAMK1G0.97248876
41MAP3K20.95870894
42CSK0.94589907
43PTK2B0.94014645
44EPHA30.93767685
45YES10.93307716
46FLT30.92603815
47MAP3K10.89775424
48CAMKK20.88993227
49EPHA20.88982206
50PRKD10.87929569
51NUAK10.87008092
52MET0.86631457
53WNK30.86361814
54PASK0.83229257
55LATS20.80633062
56RET0.79931960
57TESK10.78126612
58EPHB10.77683975
59JAK10.75071519
60ROCK20.73720642
61CDC42BPA0.71753343
62CDK60.71516213
63CAMK1D0.71422142
64GSK3A0.71067196
65IGF1R0.68062467
66ADRBK10.67686105
67WNK40.66830935
68MAPK150.66499525
69PRKCQ0.66313109
70EGFR0.63654862
71ITK0.62306091
72PAK30.61098958
73PNCK0.61087799
74IRAK30.60626354
75LIMK10.58914684
76JAK30.58641864
77TEC0.57762447
78NEK90.57582988
79KIT0.57334976
80PKN20.57186570
81WNK10.56505440
82MAP2K30.55140447
83INSR0.55095947
84TTN0.55002568
85TRIB30.54203883
86ZAP700.53846008
87ILK0.53697046
88KSR20.52391451
89CDK90.50890386
90PDPK10.50485466
91MYLK0.49681767
92FES0.49642650
93BCR0.49557010
94MAPK70.45382728
95PRKD20.45260695
96MAP3K140.45051727
97MARK30.44562848
98ROCK10.44181952
99DDR20.42377308
100JAK20.42354453
101PRKG20.41804340
102PAK40.40857845
103NTRK10.40757642
104PRKCE0.40606941
105PIK3CA0.40000767
106PAK20.39895726
107CSNK1G20.39758204
108BMPR1B0.39045381
109SRC0.38734917
110MTOR0.38418635
111PLK20.37871485
112BRAF0.37525974
113CDK120.37501557
114MAP3K110.36246337
115SGK30.36231065
116ABL10.36213917
117HCK0.34734593
118MAPK120.34600339
119STK30.33952151
120PDK20.32920571
121DYRK1B0.32106015
122CDK80.31394226
123CSNK1G10.28468511
124MAP2K10.28333517
125MAP3K80.27597178
126CHUK0.27237091
127TYRO30.27123827
128SGK2230.26230155
129DAPK30.26103526
130ABL20.25889701
131KSR10.24137521
132GRK50.20304581
133STK390.18441674
134LCK0.18136941
135FGR0.15378902
136RPS6KA20.15271906
137TBK10.14646666
138RAF10.14506061
139PIK3CG0.13800068
140MAP3K30.13086175
141EIF2AK30.12604098
142MAP4K10.10123022
143MAPK40.07782831
144DAPK10.05072799
145EEF2K0.03931026
146AKT20.03335478

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.97723054
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.98176779
3ECM-receptor interaction_Homo sapiens_hsa045122.27590410
4Adherens junction_Homo sapiens_hsa045202.24760127
5Dorso-ventral axis formation_Homo sapiens_hsa043202.21229272
6Focal adhesion_Homo sapiens_hsa045102.19203929
7Protein digestion and absorption_Homo sapiens_hsa049741.90116547
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.71260998
9Nitrogen metabolism_Homo sapiens_hsa009101.70452302
10Small cell lung cancer_Homo sapiens_hsa052221.62638253
11Insulin secretion_Homo sapiens_hsa049111.58988614
12Shigellosis_Homo sapiens_hsa051311.58352741
13Type II diabetes mellitus_Homo sapiens_hsa049301.54325399
14Amoebiasis_Homo sapiens_hsa051461.54086018
15Renal cell carcinoma_Homo sapiens_hsa052111.45563559
16Rap1 signaling pathway_Homo sapiens_hsa040151.42824717
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.41119842
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35666312
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34344703
20Pancreatic secretion_Homo sapiens_hsa049721.27884749
21PI3K-Akt signaling pathway_Homo sapiens_hsa041511.27696019
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24196387
23Insulin resistance_Homo sapiens_hsa049311.24001576
24Proteoglycans in cancer_Homo sapiens_hsa052051.22218918
25Platelet activation_Homo sapiens_hsa046111.21644101
26Malaria_Homo sapiens_hsa051441.21515157
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17148785
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15121407
29Toxoplasmosis_Homo sapiens_hsa051451.14757009
30Vascular smooth muscle contraction_Homo sapiens_hsa042701.14630043
31Vibrio cholerae infection_Homo sapiens_hsa051101.11017887
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10664005
33Renin secretion_Homo sapiens_hsa049241.10474058
34mTOR signaling pathway_Homo sapiens_hsa041501.10206122
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09385533
36Prostate cancer_Homo sapiens_hsa052151.06768641
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05099635
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04699093
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04245807
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03854383
41Sulfur metabolism_Homo sapiens_hsa009201.03742167
42Dilated cardiomyopathy_Homo sapiens_hsa054141.02544876
43Ras signaling pathway_Homo sapiens_hsa040141.02070517
44Thyroid hormone synthesis_Homo sapiens_hsa049180.97678883
45African trypanosomiasis_Homo sapiens_hsa051430.97523657
46MicroRNAs in cancer_Homo sapiens_hsa052060.97171502
47Complement and coagulation cascades_Homo sapiens_hsa046100.96322360
48Axon guidance_Homo sapiens_hsa043600.94904868
49Type I diabetes mellitus_Homo sapiens_hsa049400.92448947
50Pancreatic cancer_Homo sapiens_hsa052120.92200259
51Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90227170
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87908742
53Pathways in cancer_Homo sapiens_hsa052000.87890630
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87493733
55Gap junction_Homo sapiens_hsa045400.85738010
56Estrogen signaling pathway_Homo sapiens_hsa049150.85696164
57Chronic myeloid leukemia_Homo sapiens_hsa052200.84926032
58VEGF signaling pathway_Homo sapiens_hsa043700.84682432
59Glioma_Homo sapiens_hsa052140.83402703
60Endometrial cancer_Homo sapiens_hsa052130.83097702
61TGF-beta signaling pathway_Homo sapiens_hsa043500.81458939
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81305210
63Proteasome_Homo sapiens_hsa030500.78241752
64Prion diseases_Homo sapiens_hsa050200.77183727
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76600795
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76223992
67FoxO signaling pathway_Homo sapiens_hsa040680.74895589
68Pertussis_Homo sapiens_hsa051330.72945516
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72900865
70Notch signaling pathway_Homo sapiens_hsa043300.72860350
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72191335
72Melanoma_Homo sapiens_hsa052180.71990198
73cAMP signaling pathway_Homo sapiens_hsa040240.71911151
74Renin-angiotensin system_Homo sapiens_hsa046140.68463391
75Glucagon signaling pathway_Homo sapiens_hsa049220.68213872
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67790223
77Lysine degradation_Homo sapiens_hsa003100.67244835
78Gastric acid secretion_Homo sapiens_hsa049710.65125779
79Endocytosis_Homo sapiens_hsa041440.64709212
80HIF-1 signaling pathway_Homo sapiens_hsa040660.63331761
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.63054473
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62560360
83Cocaine addiction_Homo sapiens_hsa050300.62336097
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62188184
85Phagosome_Homo sapiens_hsa041450.61992717
86Bile secretion_Homo sapiens_hsa049760.61147689
87N-Glycan biosynthesis_Homo sapiens_hsa005100.60833581
88Prolactin signaling pathway_Homo sapiens_hsa049170.60532262
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60332757
90MAPK signaling pathway_Homo sapiens_hsa040100.60239565
91Hippo signaling pathway_Homo sapiens_hsa043900.59987035
92Cholinergic synapse_Homo sapiens_hsa047250.59288663
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59199379
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.58030223
95Tight junction_Homo sapiens_hsa045300.57990873
96Chemokine signaling pathway_Homo sapiens_hsa040620.57727099
97TNF signaling pathway_Homo sapiens_hsa046680.57707488
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57047278
99Colorectal cancer_Homo sapiens_hsa052100.55785327
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55601113
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53986886
102Melanogenesis_Homo sapiens_hsa049160.52728916
103Osteoclast differentiation_Homo sapiens_hsa043800.52414297
104ABC transporters_Homo sapiens_hsa020100.52055684
105Glutathione metabolism_Homo sapiens_hsa004800.51835583
106Bladder cancer_Homo sapiens_hsa052190.51661821
107Rheumatoid arthritis_Homo sapiens_hsa053230.51621911
108Other glycan degradation_Homo sapiens_hsa005110.50816124
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50086953
110Protein export_Homo sapiens_hsa030600.50053052
111Thyroid cancer_Homo sapiens_hsa052160.49900501
112B cell receptor signaling pathway_Homo sapiens_hsa046620.49812186
113Lysosome_Homo sapiens_hsa041420.49659443
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47548334
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.47096285
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47048438
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46239842
118Salmonella infection_Homo sapiens_hsa051320.45987807
119Apoptosis_Homo sapiens_hsa042100.44670296
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44236168
121Choline metabolism in cancer_Homo sapiens_hsa052310.43307688
122Sphingolipid metabolism_Homo sapiens_hsa006000.39306633
123GnRH signaling pathway_Homo sapiens_hsa049120.39101383
124Hematopoietic cell lineage_Homo sapiens_hsa046400.34172321
125p53 signaling pathway_Homo sapiens_hsa041150.30099911
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29786239
127Pentose phosphate pathway_Homo sapiens_hsa000300.28763814
128Arginine biosynthesis_Homo sapiens_hsa002200.28463965
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.25103459
130Folate biosynthesis_Homo sapiens_hsa007900.24964033
131Hepatitis B_Homo sapiens_hsa051610.24882719
132ErbB signaling pathway_Homo sapiens_hsa040120.22397894
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.21842113
134Sulfur relay system_Homo sapiens_hsa041220.19362270

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