ESPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.91652340
2proline biosynthetic process (GO:0006561)4.82310744
3protein localization to kinetochore (GO:0034501)4.79835896
4replication fork processing (GO:0031297)4.79365500
5maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.60192554
6chromosome condensation (GO:0030261)4.58405637
7somatic hypermutation of immunoglobulin genes (GO:0016446)4.42848770
8somatic diversification of immune receptors via somatic mutation (GO:0002566)4.42848770
9telomere maintenance via semi-conservative replication (GO:0032201)4.26253572
10DNA strand elongation involved in DNA replication (GO:0006271)4.23517355
11embryonic process involved in female pregnancy (GO:0060136)4.18811252
12mitotic nuclear envelope disassembly (GO:0007077)4.17538996
13transcription from mitochondrial promoter (GO:0006390)4.15237214
14protein localization to chromosome, centromeric region (GO:0071459)4.11719706
15regulation of translational fidelity (GO:0006450)4.07015963
16formation of translation preinitiation complex (GO:0001731)4.04287786
17nuclear pore organization (GO:0006999)4.03889467
18* mitotic sister chromatid segregation (GO:0000070)4.03495550
19DNA unwinding involved in DNA replication (GO:0006268)4.02899674
20establishment of apical/basal cell polarity (GO:0035089)4.01240570
21DNA strand elongation (GO:0022616)4.01161604
22DNA packaging (GO:0006323)3.94221585
23kinetochore organization (GO:0051383)3.92855549
24mitotic metaphase plate congression (GO:0007080)3.88260026
25DNA strand renaturation (GO:0000733)3.88119100
26membrane disassembly (GO:0030397)3.87522881
27nuclear envelope disassembly (GO:0051081)3.87522881
28regulation of gene silencing by RNA (GO:0060966)3.86246250
29regulation of posttranscriptional gene silencing (GO:0060147)3.86246250
30regulation of gene silencing by miRNA (GO:0060964)3.86246250
31nuclear pore complex assembly (GO:0051292)3.82844946
32mitotic G1 DNA damage checkpoint (GO:0031571)3.81412719
33kinetochore assembly (GO:0051382)3.80691642
34telomere maintenance via recombination (GO:0000722)3.76345538
35negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.75416077
36pre-miRNA processing (GO:0031054)3.74220938
37dosage compensation (GO:0007549)3.73157417
38nucleotide-excision repair, DNA gap filling (GO:0006297)3.72486207
39DNA replication-dependent nucleosome organization (GO:0034723)3.72452449
40DNA replication-dependent nucleosome assembly (GO:0006335)3.72452449
41DNA replication initiation (GO:0006270)3.70037127
42DNA ligation (GO:0006266)3.68971755
43regulation of RNA export from nucleus (GO:0046831)3.68302762
44base-excision repair (GO:0006284)3.67043793
45* sister chromatid segregation (GO:0000819)3.66811656
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.64409257
47spliceosomal tri-snRNP complex assembly (GO:0000244)3.61755181
48mitotic recombination (GO:0006312)3.59473478
49mitotic chromosome condensation (GO:0007076)3.57149296
50mitochondrial DNA metabolic process (GO:0032042)3.57099726
51heterochromatin organization (GO:0070828)3.56420119
52regulation of integrin activation (GO:0033623)3.55969497
53DNA deamination (GO:0045006)3.54936568
54CENP-A containing nucleosome assembly (GO:0034080)3.52330933
55DNA synthesis involved in DNA repair (GO:0000731)3.48958721
56chromatin remodeling at centromere (GO:0031055)3.46336163
57establishment of integrated proviral latency (GO:0075713)3.43506947
58spindle checkpoint (GO:0031577)3.43119427
59DNA duplex unwinding (GO:0032508)3.42851240
60regulation of centriole replication (GO:0046599)3.42352099
61DNA topological change (GO:0006265)3.42143412
62DNA geometric change (GO:0032392)3.41853414
63chromatin assembly or disassembly (GO:0006333)3.40874668
64regulation of double-strand break repair via homologous recombination (GO:0010569)3.39004675
65negative regulation of mRNA processing (GO:0050686)3.38388400
66metaphase plate congression (GO:0051310)3.35792696
67DNA replication checkpoint (GO:0000076)3.35051109
68establishment of monopolar cell polarity (GO:0061162)3.34956055
69establishment or maintenance of monopolar cell polarity (GO:0061339)3.34956055
70telomere maintenance via telomere lengthening (GO:0010833)3.34581956
71mitotic G1/S transition checkpoint (GO:0044819)3.33033380
72protein complex localization (GO:0031503)3.32582773
73regulation of double-strand break repair (GO:2000779)3.32509350
74G1 DNA damage checkpoint (GO:0044783)3.32444956
75mRNA cleavage (GO:0006379)3.29620057
76proline metabolic process (GO:0006560)3.28312319
77histone H4-K12 acetylation (GO:0043983)3.26259317
78regulation of spindle organization (GO:0090224)3.26242361
79nuclear envelope organization (GO:0006998)3.24890085
80negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24625909
81* negative regulation of chromosome segregation (GO:0051985)3.24625909
82negative regulation of sister chromatid segregation (GO:0033046)3.24625909
83negative regulation of mitotic sister chromatid separation (GO:2000816)3.24625909
84negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.24625909
85negative regulation of mitotic sister chromatid segregation (GO:0033048)3.24625909
86mitotic spindle checkpoint (GO:0071174)3.23838458
87viral mRNA export from host cell nucleus (GO:0046784)3.23313345
88regulation of DNA damage checkpoint (GO:2000001)3.21484822
89mitotic spindle assembly checkpoint (GO:0007094)3.19278209
90microtubule depolymerization (GO:0007019)3.18700890
91regulation of centrosome cycle (GO:0046605)3.18299715
92regulation of histone H3-K9 methylation (GO:0051570)3.17924349
93termination of RNA polymerase II transcription (GO:0006369)3.17559540
94DNA replication-independent nucleosome organization (GO:0034724)3.17287344
95DNA replication-independent nucleosome assembly (GO:0006336)3.17287344
96regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15406151
97spindle assembly checkpoint (GO:0071173)3.14256787
98V(D)J recombination (GO:0033151)3.13570621
99positive regulation of protein homooligomerization (GO:0032464)3.13457595
100attachment of spindle microtubules to kinetochore (GO:0008608)3.12981462
101negative regulation of RNA splicing (GO:0033119)3.11374700
102* mitotic cell cycle (GO:0000278)3.08710929
103chromatin assembly (GO:0031497)3.07745200
104DNA double-strand break processing (GO:0000729)3.07054909
105positive regulation of DNA-dependent DNA replication (GO:2000105)3.06484883
106folic acid-containing compound biosynthetic process (GO:0009396)3.06303972
107mRNA transport (GO:0051028)3.05923589
108protein localization to chromosome (GO:0034502)3.05486200
109ATP-dependent chromatin remodeling (GO:0043044)3.04740624
110regulation of DNA endoreduplication (GO:0032875)3.02411414
111* regulation of sister chromatid segregation (GO:0033045)3.02157465
112* regulation of mitotic sister chromatid separation (GO:0010965)3.02157465
113* regulation of mitotic sister chromatid segregation (GO:0033047)3.02157465
114non-recombinational repair (GO:0000726)3.01758065
115double-strand break repair via nonhomologous end joining (GO:0006303)3.01758065
116* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01192103
117* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01192103
118regulation of centrosome duplication (GO:0010824)3.00949219
119establishment of chromosome localization (GO:0051303)3.00376261
120spindle assembly involved in mitosis (GO:0090307)3.00043222
121* positive regulation of chromosome segregation (GO:0051984)2.97451933
122negative regulation of mRNA metabolic process (GO:1903312)2.97258492
123* spindle organization (GO:0007051)2.96624418
124DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.96552719
125trophectodermal cell differentiation (GO:0001829)2.96388590
126regulation of spindle checkpoint (GO:0090231)2.96254691
127spindle assembly (GO:0051225)2.95920094
128* regulation of chromosome segregation (GO:0051983)2.95246043
129DNA conformation change (GO:0071103)2.95165490
130* chromosome segregation (GO:0007059)2.95020678
131L-serine metabolic process (GO:0006563)2.94584443
132maturation of 5.8S rRNA (GO:0000460)2.94294568
133protein K6-linked ubiquitination (GO:0085020)2.94276542
134nucleobase biosynthetic process (GO:0046112)2.92244279
135translesion synthesis (GO:0019985)2.92134943
136determination of adult lifespan (GO:0008340)2.90787478
137negative regulation of histone methylation (GO:0031061)2.90212564
138mRNA export from nucleus (GO:0006406)2.89840499
139pore complex assembly (GO:0046931)2.89142250
140regulation of mitotic spindle organization (GO:0060236)2.88083126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.08209910
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.12823633
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.53554249
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38656229
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.23577025
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85505283
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79185278
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.69790372
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38932569
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.29085243
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28703563
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.27790601
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.27790601
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.27790601
15MYC_22102868_ChIP-Seq_BL_Human2.09150878
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.98018937
17E2F1_21310950_ChIP-Seq_MCF-7_Human1.94782937
18NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93136788
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91567597
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86254990
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85837853
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.84076527
23AR_21909140_ChIP-Seq_LNCAP_Human1.80682781
24VDR_21846776_ChIP-Seq_THP-1_Human1.80503404
25* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79376752
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.78968094
27XRN2_22483619_ChIP-Seq_HELA_Human1.76049471
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74478105
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.73359474
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.72720870
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.72339421
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.69821853
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.68756253
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66190364
35NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.61921190
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59659679
37* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.57787278
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53543137
39KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52236528
40NANOG_21062744_ChIP-ChIP_HESCs_Human1.52052771
41SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.50144213
42TCF3_18692474_ChIP-Seq_MESCs_Mouse1.49901900
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48740730
44* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.47887505
45KDM5A_27292631_Chip-Seq_BREAST_Human1.47760147
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46232829
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45932461
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.43162477
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41895059
50* EST1_17652178_ChIP-ChIP_JURKAT_Human1.41850806
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.41694508
52GABP_19822575_ChIP-Seq_HepG2_Human1.41663735
53* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40342882
54DCP1A_22483619_ChIP-Seq_HELA_Human1.38276931
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37825180
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37254578
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35062571
58POU5F1_16518401_ChIP-PET_MESCs_Mouse1.34120374
59* TTF2_22483619_ChIP-Seq_HELA_Human1.33877771
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32606535
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.32011399
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31024683
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30248356
64VDR_23849224_ChIP-Seq_CD4+_Human1.29566474
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29112871
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.24371129
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22556567
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21086857
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20723497
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20332602
71NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.19650452
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17550919
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17010575
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16336497
75FOXP3_21729870_ChIP-Seq_TREG_Human1.15820970
76CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14384168
77* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13091506
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12682314
79TFEB_21752829_ChIP-Seq_HELA_Human1.11118998
80NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09615777
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08878407
82SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08868959
83* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08610181
84GABP_17652178_ChIP-ChIP_JURKAT_Human1.07720216
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07666742
86POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.07067153
87CIITA_25753668_ChIP-Seq_RAJI_Human1.06937252
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04175603
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04071454
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03023001
91ZNF263_19887448_ChIP-Seq_K562_Human1.02464104
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01023315
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00848467
94SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99277940
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98903521
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97798641
97ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96912415
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96875736
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96765530
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96651397
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96485718
102NANOG_18692474_ChIP-Seq_MESCs_Mouse0.92681484
103PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91908328
104CHD1_26751641_Chip-Seq_LNCaP_Human0.91744927
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91502837
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91385181
107ELK1_19687146_ChIP-ChIP_HELA_Human0.89533072
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88693839
109ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87924835
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87868506
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87717660
112TCF7_22412390_ChIP-Seq_EML_Mouse0.86444694
113KDM2B_26808549_Chip-Seq_DND41_Human0.84971126
114KAP1_27257070_Chip-Seq_ESCs_Mouse0.83619184
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82776925
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81320135
117MYC_18940864_ChIP-ChIP_HL60_Human0.80585797
118HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.79302073
119SRF_21415370_ChIP-Seq_HL-1_Mouse0.77456731
120* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75449937
121NOTCH1_21737748_ChIP-Seq_TLL_Human0.75426044
122SOX17_20123909_ChIP-Seq_XEN_Mouse0.74831643
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72781380
124NCOR1_26117541_ChIP-Seq_K562_Human0.72730050
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.71747284
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.71708087
127FOXP1_21924763_ChIP-Seq_HESCs_Human0.70188122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.43682702
2MP0010094_abnormal_chromosome_stability4.32879717
3* MP0003111_abnormal_nucleus_morphology3.75191772
4MP0003693_abnormal_embryo_hatching3.71940567
5* MP0004957_abnormal_blastocyst_morpholog3.32918044
6* MP0003077_abnormal_cell_cycle3.18477546
7MP0009278_abnormal_bone_marrow2.82748789
8MP0008058_abnormal_DNA_repair2.69213683
9MP0010030_abnormal_orbit_morphology2.63158873
10MP0008877_abnormal_DNA_methylation2.49564098
11MP0010352_gastrointestinal_tract_polyps2.42924853
12MP0001730_embryonic_growth_arrest2.28349100
13MP0005076_abnormal_cell_differentiation2.27190362
14MP0003786_premature_aging2.09397713
15* MP0000350_abnormal_cell_proliferation2.07358756
16MP0010307_abnormal_tumor_latency2.07171876
17MP0002084_abnormal_developmental_patter2.00644961
18MP0003890_abnormal_embryonic-extraembry2.00472265
19* MP0008932_abnormal_embryonic_tissue1.98772374
20MP0002877_abnormal_melanocyte_morpholog1.96240121
21* MP0001697_abnormal_embryo_size1.93140918
22* MP0005380_embryogenesis_phenotype1.93064138
23* MP0001672_abnormal_embryogenesis/_devel1.93064138
24* MP0002085_abnormal_embryonic_tissue1.90557058
25MP0002653_abnormal_ependyma_morphology1.89611904
26MP0002086_abnormal_extraembryonic_tissu1.89568427
27MP0004233_abnormal_muscle_weight1.85315927
28MP0008007_abnormal_cellular_replicative1.84626382
29MP0004197_abnormal_fetal_growth/weight/1.82465027
30MP0001346_abnormal_lacrimal_gland1.72134349
31MP0005397_hematopoietic_system_phenotyp1.70308831
32MP0001545_abnormal_hematopoietic_system1.70308831
33MP0000490_abnormal_crypts_of1.64512468
34MP0003119_abnormal_digestive_system1.62288868
35* MP0003984_embryonic_growth_retardation1.61420157
36MP0009672_abnormal_birth_weight1.59186856
37* MP0002080_prenatal_lethality1.58210359
38MP0008995_early_reproductive_senescence1.57892463
39* MP0002088_abnormal_embryonic_growth/wei1.57224541
40MP0009697_abnormal_copulation1.55322786
41MP0001293_anophthalmia1.54814332
42MP0004185_abnormal_adipocyte_glucose1.54654425
43MP0003567_abnormal_fetal_cardiomyocyte1.51295170
44MP0002396_abnormal_hematopoietic_system1.45688954
45MP0004133_heterotaxia1.45335787
46MP0003123_paternal_imprinting1.44413006
47MP0005171_absent_coat_pigmentation1.40263217
48MP0002009_preneoplasia1.38351410
49MP0010234_abnormal_vibrissa_follicle1.37184455
50MP0003705_abnormal_hypodermis_morpholog1.37145379
51MP0003718_maternal_effect1.35812562
52MP0002019_abnormal_tumor_incidence1.34854219
53MP0001661_extended_life_span1.26844549
54MP0002210_abnormal_sex_determination1.26164679
55* MP0000313_abnormal_cell_death1.22894229
56MP0003283_abnormal_digestive_organ1.22656997
57MP0001145_abnormal_male_reproductive1.21054075
58MP0002111_abnormal_tail_morphology1.11899915
59MP0002249_abnormal_larynx_morphology1.10001398
60MP0004264_abnormal_extraembryonic_tissu1.09349199
61* MP0001929_abnormal_gametogenesis1.09141368
62MP0003315_abnormal_perineum_morphology1.01728122
63MP0000566_synostosis1.00980202
64MP0002282_abnormal_trachea_morphology1.00962463
65MP0002163_abnormal_gland_morphology1.00884087
66MP0005174_abnormal_tail_pigmentation1.00620465
67MP0003453_abnormal_keratinocyte_physiol1.00119605
68MP0000653_abnormal_sex_gland0.98890993
69MP0009053_abnormal_anal_canal0.98485486
70MP0003566_abnormal_cell_adhesion0.96580029
71MP0004808_abnormal_hematopoietic_stem0.95174224
72MP0000371_diluted_coat_color0.91712432
73MP0000358_abnormal_cell_content/0.90921397
74MP0006292_abnormal_olfactory_placode0.90201149
75MP0003943_abnormal_hepatobiliary_system0.88630463
76MP0003935_abnormal_craniofacial_develop0.87771696
77MP0003121_genomic_imprinting0.87548673
78MP0001915_intracranial_hemorrhage0.86853011
79MP0009333_abnormal_splenocyte_physiolog0.86746627
80MP0000432_abnormal_head_morphology0.86598536
81MP0001849_ear_inflammation0.86420781
82MP0005023_abnormal_wound_healing0.83194507
83MP0003941_abnormal_skin_development0.82881737
84MP0000703_abnormal_thymus_morphology0.80653728
85MP0001286_abnormal_eye_development0.80596086
86MP0002697_abnormal_eye_size0.80438822
87MP0002932_abnormal_joint_morphology0.80371954
88MP0009703_decreased_birth_body0.79833058
89MP0002092_abnormal_eye_morphology0.78836346
90MP0006072_abnormal_retinal_apoptosis0.77548498
91MP0002075_abnormal_coat/hair_pigmentati0.77040449
92MP0005501_abnormal_skin_physiology0.76015677
93MP0003136_yellow_coat_color0.75109986
94MP0002114_abnormal_axial_skeleton0.74964769
95MP0006035_abnormal_mitochondrial_morpho0.74645540
96MP0003755_abnormal_palate_morphology0.74030831
97MP0002925_abnormal_cardiovascular_devel0.73601148
98MP0000003_abnormal_adipose_tissue0.73112023
99MP0005623_abnormal_meninges_morphology0.72113630
100MP0003937_abnormal_limbs/digits/tail_de0.70992794
101MP0001119_abnormal_female_reproductive0.70326718
102MP0005621_abnormal_cell_physiology0.69592757
103MP0000537_abnormal_urethra_morphology0.68514009
104MP0000689_abnormal_spleen_morphology0.68430378
105MP0002269_muscular_atrophy0.68079539
106MP0003698_abnormal_male_reproductive0.67942444
107MP0003942_abnormal_urinary_system0.67093901
108MP0000678_abnormal_parathyroid_gland0.67070970
109MP0002796_impaired_skin_barrier0.67035090
110MP0000477_abnormal_intestine_morphology0.66871617
111MP0003699_abnormal_female_reproductive0.66356215
112* MP0003861_abnormal_nervous_system0.66196075
113MP0005451_abnormal_body_composition0.65272671
114* MP0002161_abnormal_fertility/fecundity0.64718607
115MP0002722_abnormal_immune_system0.63792550
116MP0002098_abnormal_vibrissa_morphology0.63273725
117MP0000470_abnormal_stomach_morphology0.63165973
118MP0003115_abnormal_respiratory_system0.63043433
119MP0000733_abnormal_muscle_development0.62085561
120MP0005384_cellular_phenotype0.61824519
121MP0002160_abnormal_reproductive_system0.61297007
122MP0002116_abnormal_craniofacial_bone0.61105323
123MP0008770_decreased_survivor_rate0.61044742
124MP0000428_abnormal_craniofacial_morphol0.60778902
125MP0003385_abnormal_body_wall0.60393110
126MP0001727_abnormal_embryo_implantation0.59324944
127MP0001348_abnormal_lacrimal_gland0.57319713
128MP0001919_abnormal_reproductive_system0.56459260
129MP0002938_white_spotting0.56075723

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.32297495
2Facial hemangioma (HP:0000329)4.13790161
3Selective tooth agenesis (HP:0001592)3.70730704
4Absent radius (HP:0003974)3.64342348
5Rectal fistula (HP:0100590)3.42074908
6Rectovaginal fistula (HP:0000143)3.42074908
7Aplasia involving forearm bones (HP:0009822)3.41134958
8Absent forearm bone (HP:0003953)3.41134958
9Patellar aplasia (HP:0006443)3.39805262
10Short humerus (HP:0005792)3.39530302
11Aplasia/hypoplasia of the humerus (HP:0006507)3.39294166
12Ependymoma (HP:0002888)3.36666313
13Abnormality of the labia minora (HP:0012880)3.32793335
14Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.32100855
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.29962379
16Intestinal fistula (HP:0100819)3.27844711
17Chromsome breakage (HP:0040012)3.25764482
18Absent thumb (HP:0009777)3.22407741
19Poikiloderma (HP:0001029)3.18961866
20Aplasia/Hypoplasia of the patella (HP:0006498)3.14583016
21Ulnar bowing (HP:0003031)3.05444907
22Basal cell carcinoma (HP:0002671)3.03459024
23Volvulus (HP:0002580)3.01408550
24Abnormality of the astrocytes (HP:0100707)2.99538587
25Astrocytoma (HP:0009592)2.99538587
26Abnormality of the ileum (HP:0001549)2.93147096
27Impulsivity (HP:0100710)2.90854981
28Squamous cell carcinoma (HP:0002860)2.85681932
29Vaginal fistula (HP:0004320)2.84918644
30Annular pancreas (HP:0001734)2.82330901
31Pustule (HP:0200039)2.81552146
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.80739575
33Abnormality of the carotid arteries (HP:0005344)2.79848881
34Broad distal phalanx of finger (HP:0009836)2.78230680
35Breast hypoplasia (HP:0003187)2.78140557
36Neoplasm of the oral cavity (HP:0100649)2.75154002
37Hypochromic microcytic anemia (HP:0004840)2.71711574
38Birth length less than 3rd percentile (HP:0003561)2.66173548
39Medulloblastoma (HP:0002885)2.61603533
40High anterior hairline (HP:0009890)2.55245101
41Rhabdomyosarcoma (HP:0002859)2.54597370
42Tongue fasciculations (HP:0001308)2.54011053
43Male infertility (HP:0003251)2.52494095
44Abnormal number of incisors (HP:0011064)2.52255979
45Concave nail (HP:0001598)2.52216602
46Abnormality of cochlea (HP:0000375)2.50681017
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.48819552
48Abnormal lung lobation (HP:0002101)2.45510909
49Orthostatic hypotension (HP:0001278)2.44944377
50Cortical dysplasia (HP:0002539)2.44602636
51Microvesicular hepatic steatosis (HP:0001414)2.43485623
52Meckel diverticulum (HP:0002245)2.43228544
53Abnormality of the duodenum (HP:0002246)2.41313868
54Sloping forehead (HP:0000340)2.41072558
55Glioma (HP:0009733)2.40666767
56Short thumb (HP:0009778)2.40517943
57Abnormality of chromosome stability (HP:0003220)2.40049390
58Progressive muscle weakness (HP:0003323)2.38917065
59Duplication of thumb phalanx (HP:0009942)2.38901465
60Horseshoe kidney (HP:0000085)2.36863642
61Septate vagina (HP:0001153)2.36282820
62Muscle fibrillation (HP:0010546)2.34099901
63Ectopic kidney (HP:0000086)2.30269737
64Abnormality of chromosome segregation (HP:0002916)2.28803042
65Abnormality of DNA repair (HP:0003254)2.28675431
66Overlapping toe (HP:0001845)2.28072593
67Hyperacusis (HP:0010780)2.26437641
68High pitched voice (HP:0001620)2.25077704
69Atresia of the external auditory canal (HP:0000413)2.24697906
70Vertebral hypoplasia (HP:0008417)2.24435464
71Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.24435464
72Premature graying of hair (HP:0002216)2.23695511
73Neoplasm of striated muscle (HP:0009728)2.22263364
74Intestinal atresia (HP:0011100)2.21210116
75Myelodysplasia (HP:0002863)2.21172565
76Broad alveolar ridges (HP:0000187)2.20894291
77Missing ribs (HP:0000921)2.20548770
78Abnormality of the preputium (HP:0100587)2.18160301
79Supernumerary spleens (HP:0009799)2.18073073
80Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17421979
81Clubbing of toes (HP:0100760)2.16456184
82Spinal muscular atrophy (HP:0007269)2.14685249
83Alopecia of scalp (HP:0002293)2.12430017
84Vertebral fusion (HP:0002948)2.11697702
85Choanal atresia (HP:0000453)2.10452086
86Cafe-au-lait spot (HP:0000957)2.10286946
87Abnormality of abdominal situs (HP:0011620)2.10207015
88Abdominal situs inversus (HP:0003363)2.10207015
89Prominent nose (HP:0000448)2.08730459
90Proximal placement of thumb (HP:0009623)2.06398974
91Deep philtrum (HP:0002002)2.05253950
92Multiple enchondromatosis (HP:0005701)2.04886551
93Shawl scrotum (HP:0000049)2.04018665
94Turricephaly (HP:0000262)2.03624830
95Duodenal stenosis (HP:0100867)2.03454172
96Small intestinal stenosis (HP:0012848)2.03454172
97Degeneration of anterior horn cells (HP:0002398)2.03354299
98Abnormality of the anterior horn cell (HP:0006802)2.03354299
99Congenital hip dislocation (HP:0001374)2.03194811
100Colon cancer (HP:0003003)2.02648269
101Urethral obstruction (HP:0000796)2.02611304
102Acute lymphatic leukemia (HP:0006721)2.02384079
103Deviation of the thumb (HP:0009603)2.02008197
104Embryonal neoplasm (HP:0002898)2.01396907
105Heterotopia (HP:0002282)2.01234768
106Increased nuchal translucency (HP:0010880)2.00598104
107Reticulocytopenia (HP:0001896)2.00555602
108Triphalangeal thumb (HP:0001199)1.99962149
109Arteriovenous malformation (HP:0100026)1.99374518
110Abnormality of the renal collecting system (HP:0004742)1.99290701
111Nephroblastoma (Wilms tumor) (HP:0002667)1.97945819
112Agnosia (HP:0010524)1.96740910
113Ureteral duplication (HP:0000073)1.96318234
114Carpal bone hypoplasia (HP:0001498)1.96315340
115Hypoplasia of the radius (HP:0002984)1.93654012
116Duplicated collecting system (HP:0000081)1.91998215
117Capillary hemangiomas (HP:0005306)1.91568595
118Abnormality of reticulocytes (HP:0004312)1.91532243
119Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90411628
120Absent epiphyses (HP:0010577)1.90411628
121Hemivertebrae (HP:0002937)1.89835562
122Short 5th finger (HP:0009237)1.88737345
123Cerebral aneurysm (HP:0004944)1.87643645
124Abnormality of the lower motor neuron (HP:0002366)1.85934779
125Hypotelorism (HP:0000601)1.85004996
126Morphological abnormality of the inner ear (HP:0011390)1.84456592
127Short 4th metacarpal (HP:0010044)1.84003487
128Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84003487
129Gastrointestinal atresia (HP:0002589)1.83154855
130Premature ovarian failure (HP:0008209)1.82132350
131Broad thumb (HP:0011304)1.81550885
132Embryonal renal neoplasm (HP:0011794)1.80538277
133Progressive external ophthalmoplegia (HP:0000590)1.80220115
13411 pairs of ribs (HP:0000878)1.79917703
135Coronal craniosynostosis (HP:0004440)1.79470305
136Tracheoesophageal fistula (HP:0002575)1.79069123
137Facial cleft (HP:0002006)1.77344569
138Hypochromic anemia (HP:0001931)1.76960010
139Hypergonadotropic hypogonadism (HP:0000815)1.74259256
140Long eyelashes (HP:0000527)1.72875498
141Abnormality of the calcaneus (HP:0008364)1.72802268
142Abnormality of the fingertips (HP:0001211)1.70869163
143Abnormality of pyrimidine metabolism (HP:0004353)1.70271493
144Flared metaphyses (HP:0003015)1.68250151
145Abnormality of the phalanges of the hallux (HP:0010057)1.67983156
146Insomnia (HP:0100785)1.66645747
147Sandal gap (HP:0001852)1.65943031
148Trismus (HP:0000211)1.65163761
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.64054871
150Trigonocephaly (HP:0000243)1.61241940
151Abnormal gallbladder physiology (HP:0012438)1.60692934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.26698728
2CDC73.47262679
3CDK123.38785293
4SMG13.10984827
5BUB12.99484796
6NEK22.89164343
7WEE12.81729302
8DDR22.69426382
9MAP3K62.65969106
10CDK72.30247273
11TTK2.24837551
12PBK2.19120718
13ZAK2.02793822
14MAP3K102.01063944
15TYRO31.91378215
16CHEK21.88986096
17MAP3K111.85101385
18* PLK11.82504735
19VRK21.76522235
20MAPK151.72544209
21EEF2K1.70888307
22IRAK31.66751494
23NME21.66125417
24NEK11.63602404
25BMX1.60327322
26MATK1.59860611
27CDK61.56978353
28FGR1.55506388
29ATR1.54422151
30LATS21.52095625
31RPS6KB21.51956366
32CDK41.45750021
33EPHA21.44068785
34STK101.43838653
35PIM11.41743994
36AURKB1.39889119
37BRSK21.32023802
38TAF11.30344343
39DYRK31.30029496
40CHEK11.29643071
41PDGFRA1.28674329
42DAPK11.25093983
43UHMK11.22169140
44MTOR1.13998004
45PRKD21.12734855
46AURKA1.12384274
47MAP3K81.10081983
48STK31.09784484
49BRD41.08021923
50DYRK1B1.07777334
51CSK1.07475503
52BRAF1.07275126
53YES11.06010880
54PINK11.05161298
55CDK21.02903034
56SRPK11.02318726
57STK41.01809092
58BRSK11.00901840
59TLK11.00296161
60MST1R0.98603334
61AKT30.98275410
62ATM0.96874379
63LATS10.93290848
64CLK10.92372464
65ALK0.87829599
66TESK20.87334896
67PIM20.87208178
68TRPM70.86276784
69MKNK10.85555116
70CAMK1D0.85413437
71TSSK60.83303207
72PLK40.81474101
73CCNB10.81358645
74MELK0.80712743
75MKNK20.80590630
76MAPK110.79687989
77ACVR1B0.78477479
78PAK40.76718444
79RPS6KC10.76062348
80RPS6KL10.76062348
81TRIB30.74866500
82MAP3K90.73846244
83PASK0.73106839
84PLK30.72411904
85CAMK1G0.69922492
86* CDK10.68804136
87CDC42BPA0.65805855
88RPS6KA60.65758396
89PKN20.64602135
90EIF2AK10.63808903
91CDK90.62410830
92PAK10.57653328
93RPS6KA10.55680806
94MET0.55285775
95CSNK2A10.52895117
96PRPF4B0.52584614
97CSNK2A20.51340868
98EIF2AK20.51212500
99GSK3A0.49497544
100STK38L0.49183155
101FLT30.49060295
102PNCK0.48357354
103SIK10.47789167
104MAPK140.46881788
105RPS6KA40.45842506
106PAK20.45790704
107MAPKAPK30.44662147
108CDK11A0.43910178
109AKT20.43228194
110CDK150.42206934
111SCYL20.41467975
112* MAPK10.40191628
113PRKAA10.39979886
114CDK180.39780356
115PRKCI0.39745775
116PRKDC0.39701546
117VRK10.38245720
118NME10.37830048
119RPS6KA50.37145710
120MAP4K10.36565258
121KDR0.35544894
122RAF10.35026019
123CSNK1E0.34711676
124KSR20.34310746
125RPS6KB10.33684079
126TAOK20.33066978
127PRKD30.32521274
128AKT10.32409992
129CDK80.32283694
130GSK3B0.32016027
131MAP2K20.31465934
132FGFR40.28349343
133CDK30.27241107
134IRAK20.26206201
135CDK140.25915525
136EIF2AK30.24591634
137MARK30.24222639

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.84364733
2DNA replication_Homo sapiens_hsa030304.82740895
3Base excision repair_Homo sapiens_hsa034103.96172712
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32243784
5RNA transport_Homo sapiens_hsa030133.19355790
6Spliceosome_Homo sapiens_hsa030403.03735657
7Homologous recombination_Homo sapiens_hsa034402.92789686
8Nucleotide excision repair_Homo sapiens_hsa034202.82122241
9* Cell cycle_Homo sapiens_hsa041102.79163645
10Fanconi anemia pathway_Homo sapiens_hsa034602.62717796
11mRNA surveillance pathway_Homo sapiens_hsa030152.40690483
12One carbon pool by folate_Homo sapiens_hsa006702.26034351
13p53 signaling pathway_Homo sapiens_hsa041151.95502202
14Fatty acid biosynthesis_Homo sapiens_hsa000611.94904947
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79679555
16RNA polymerase_Homo sapiens_hsa030201.74150175
17Non-homologous end-joining_Homo sapiens_hsa034501.54832636
18RNA degradation_Homo sapiens_hsa030181.48556727
19Ribosome_Homo sapiens_hsa030101.46827942
20Basal transcription factors_Homo sapiens_hsa030221.44606552
21Notch signaling pathway_Homo sapiens_hsa043301.37833264
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36382416
23Pyrimidine metabolism_Homo sapiens_hsa002401.33837218
24Hippo signaling pathway_Homo sapiens_hsa043901.32323759
25mTOR signaling pathway_Homo sapiens_hsa041501.31390610
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29841218
27* Oocyte meiosis_Homo sapiens_hsa041141.20554037
28Hedgehog signaling pathway_Homo sapiens_hsa043401.20190498
29MicroRNAs in cancer_Homo sapiens_hsa052061.18641964
30Viral carcinogenesis_Homo sapiens_hsa052031.18391643
31Systemic lupus erythematosus_Homo sapiens_hsa053221.15106011
32Biosynthesis of amino acids_Homo sapiens_hsa012301.14586513
33Adherens junction_Homo sapiens_hsa045201.10037637
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09737647
35Basal cell carcinoma_Homo sapiens_hsa052171.09434651
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06801127
37Carbon metabolism_Homo sapiens_hsa012001.02008912
38TGF-beta signaling pathway_Homo sapiens_hsa043501.01431199
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98815537
40Lysine degradation_Homo sapiens_hsa003100.97645974
41Epstein-Barr virus infection_Homo sapiens_hsa051690.96299297
42Proteasome_Homo sapiens_hsa030500.95686001
43Small cell lung cancer_Homo sapiens_hsa052220.94960334
44Bladder cancer_Homo sapiens_hsa052190.90438098
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90149823
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88888381
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88070591
48Herpes simplex infection_Homo sapiens_hsa051680.87233937
49HTLV-I infection_Homo sapiens_hsa051660.85162858
50Colorectal cancer_Homo sapiens_hsa052100.81993000
51N-Glycan biosynthesis_Homo sapiens_hsa005100.81847804
52Chronic myeloid leukemia_Homo sapiens_hsa052200.77921935
53Selenocompound metabolism_Homo sapiens_hsa004500.71766117
54Pyruvate metabolism_Homo sapiens_hsa006200.70534113
55Vitamin B6 metabolism_Homo sapiens_hsa007500.67257333
56Thyroid cancer_Homo sapiens_hsa052160.67003425
57Wnt signaling pathway_Homo sapiens_hsa043100.66908379
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66528866
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66013969
60Shigellosis_Homo sapiens_hsa051310.65943568
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65256986
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63045717
63Folate biosynthesis_Homo sapiens_hsa007900.60467585
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.57948916
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57402266
66Fructose and mannose metabolism_Homo sapiens_hsa000510.55379357
67Primary immunodeficiency_Homo sapiens_hsa053400.54002227
68Sulfur relay system_Homo sapiens_hsa041220.53186461
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52708065
70Viral myocarditis_Homo sapiens_hsa054160.51488981
71Arginine and proline metabolism_Homo sapiens_hsa003300.50434277
72Legionellosis_Homo sapiens_hsa051340.50364303
73Antigen processing and presentation_Homo sapiens_hsa046120.49652665
74Tight junction_Homo sapiens_hsa045300.49591765
75Acute myeloid leukemia_Homo sapiens_hsa052210.49352504
76Purine metabolism_Homo sapiens_hsa002300.49320378
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47286534
78VEGF signaling pathway_Homo sapiens_hsa043700.47060688
79Circadian rhythm_Homo sapiens_hsa047100.46941560
80Dorso-ventral axis formation_Homo sapiens_hsa043200.45965991
81Glioma_Homo sapiens_hsa052140.45960594
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.45721173
83Steroid biosynthesis_Homo sapiens_hsa001000.45177628
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44536937
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.43690512
86Pathways in cancer_Homo sapiens_hsa052000.43543921
87Hepatitis B_Homo sapiens_hsa051610.43002870
88Pentose phosphate pathway_Homo sapiens_hsa000300.42820303
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42505119
90Prostate cancer_Homo sapiens_hsa052150.41813867
91Apoptosis_Homo sapiens_hsa042100.41585341
92Proteoglycans in cancer_Homo sapiens_hsa052050.40262181
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38719206
94Endometrial cancer_Homo sapiens_hsa052130.36592243
95Alcoholism_Homo sapiens_hsa050340.35838355
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34295958
97HIF-1 signaling pathway_Homo sapiens_hsa040660.34115102
98AMPK signaling pathway_Homo sapiens_hsa041520.33753832
99Pancreatic cancer_Homo sapiens_hsa052120.33398416
100Non-small cell lung cancer_Homo sapiens_hsa052230.31894194
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30793514
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30280264
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28054803
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28010163
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27031728
106Fatty acid elongation_Homo sapiens_hsa000620.24474467
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23872727
108Measles_Homo sapiens_hsa051620.22355833
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22018077
110B cell receptor signaling pathway_Homo sapiens_hsa046620.20949040
111Insulin signaling pathway_Homo sapiens_hsa049100.20931043
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20501308
113FoxO signaling pathway_Homo sapiens_hsa040680.19484671
114Glutathione metabolism_Homo sapiens_hsa004800.18801520
115Melanoma_Homo sapiens_hsa052180.18263383
116Focal adhesion_Homo sapiens_hsa045100.18123947
117Galactose metabolism_Homo sapiens_hsa000520.17952612
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16647863
119Inositol phosphate metabolism_Homo sapiens_hsa005620.16595238
120ErbB signaling pathway_Homo sapiens_hsa040120.15846568
121Metabolic pathways_Homo sapiens_hsa011000.15714084

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