ESPN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Mutations in this gene are associated with autosomal recessive neurosensory deafness, and autosomal dominant sensorineural deafness without vestibular involvement. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxygen transport (GO:0015671)6.60284466
2very-low-density lipoprotein particle assembly (GO:0034379)6.34490408
3intestinal absorption (GO:0050892)6.22088133
4gas transport (GO:0015669)6.03140379
5vitamin A metabolic process (GO:0006776)5.48502987
6plasma lipoprotein particle assembly (GO:0034377)5.38322168
7protoporphyrinogen IX metabolic process (GO:0046501)5.32410681
8angiotensin maturation (GO:0002003)5.12221792
9atrioventricular valve morphogenesis (GO:0003181)5.08515193
10intestinal cholesterol absorption (GO:0030299)5.08433297
11piRNA metabolic process (GO:0034587)5.05225899
12epoxygenase P450 pathway (GO:0019373)5.04906399
13fusion of sperm to egg plasma membrane (GO:0007342)4.95950960
14protein-lipid complex assembly (GO:0065005)4.68007562
15regulation of bile acid biosynthetic process (GO:0070857)4.54760765
16sulfate transmembrane transport (GO:1902358)4.53887683
17erythrocyte maturation (GO:0043249)4.48675906
18positive regulation of triglyceride lipase activity (GO:0061365)4.45126978
19positive regulation of lipoprotein lipase activity (GO:0051006)4.45126978
20peptidyl-glutamic acid carboxylation (GO:0017187)4.43742810
21protein carboxylation (GO:0018214)4.43742810
22proline metabolic process (GO:0006560)4.39091484
23synaptonemal complex assembly (GO:0007130)4.23275692
24negative regulation of fibrinolysis (GO:0051918)4.19435206
25regulation of cholesterol esterification (GO:0010872)4.17705836
26regulation of meiosis I (GO:0060631)4.08667424
27phospholipid efflux (GO:0033700)4.08055623
28regulation of triglyceride catabolic process (GO:0010896)4.06836594
29plasma lipoprotein particle organization (GO:0071827)4.02165219
30synaptonemal complex organization (GO:0070193)4.01629840
31sex determination (GO:0007530)3.98766484
32hemoglobin metabolic process (GO:0020027)3.98570884
33porphyrin-containing compound metabolic process (GO:0006778)3.96422386
34regulation of fibrinolysis (GO:0051917)3.93611709
35plasma lipoprotein particle remodeling (GO:0034369)3.92491840
36protein-lipid complex remodeling (GO:0034368)3.92491840
37macromolecular complex remodeling (GO:0034367)3.92491840
38exogenous drug catabolic process (GO:0042738)3.92357208
39triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.92023953
40ethanol metabolic process (GO:0006067)3.89714661
41high-density lipoprotein particle remodeling (GO:0034375)3.89402502
42protoporphyrinogen IX biosynthetic process (GO:0006782)3.86464442
43negative regulation of sterol transport (GO:0032372)3.81565278
44negative regulation of cholesterol transport (GO:0032375)3.81565278
45negative regulation of erythrocyte differentiation (GO:0045647)3.77544352
46sulfate transport (GO:0008272)3.75972736
47positive regulation of male gonad development (GO:2000020)3.73676932
48heterochromatin organization (GO:0070828)3.73629079
49protein-lipid complex subunit organization (GO:0071825)3.72063734
50porphyrin-containing compound biosynthetic process (GO:0006779)3.71921853
51urea metabolic process (GO:0019627)3.71423384
52ethanol oxidation (GO:0006069)3.71306965
53sex differentiation (GO:0007548)3.65850796
54urea cycle (GO:0000050)3.64749809
55drug metabolic process (GO:0017144)3.63829703
56nitrogen cycle metabolic process (GO:0071941)3.63038828
57positive regulation of lipid catabolic process (GO:0050996)3.61467133
58axonemal dynein complex assembly (GO:0070286)3.60856644
59proline biosynthetic process (GO:0006561)3.57501480
60trophectodermal cell differentiation (GO:0001829)3.57477557
61platelet formation (GO:0030220)3.55440273
62GDP-mannose metabolic process (GO:0019673)3.54962917
63regulation of protein activation cascade (GO:2000257)3.54839485
64male meiosis (GO:0007140)3.54643761
65cholesterol efflux (GO:0033344)3.50989692
66sulfur compound transport (GO:0072348)3.49633087
67tetrapyrrole biosynthetic process (GO:0033014)3.49410507
68drug transmembrane transport (GO:0006855)3.49405875
69flavonoid metabolic process (GO:0009812)3.47685969
70positive regulation of fatty acid biosynthetic process (GO:0045723)3.46669428
71regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.43413433
72arginine metabolic process (GO:0006525)3.42271975
73regulation of complement activation (GO:0030449)3.41910006
74reverse cholesterol transport (GO:0043691)3.41199332
75CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.40908427
76regulation of cholesterol homeostasis (GO:2000188)3.38294733
77hepatocyte apoptotic process (GO:0097284)3.37027816
78sodium ion export (GO:0071436)3.36594254
79motile cilium assembly (GO:0044458)3.35465282
80positive regulation of histone deacetylation (GO:0031065)3.35411107
81low-density lipoprotein particle remodeling (GO:0034374)3.34607685
82plasma membrane fusion (GO:0045026)3.33464740
83L-phenylalanine catabolic process (GO:0006559)3.32918936
84erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.32918936
85heme metabolic process (GO:0042168)3.32664681
86intestinal epithelial cell development (GO:0060576)3.28304455
87erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.27235582
88L-phenylalanine metabolic process (GO:0006558)3.27235582
89epithelial cell-cell adhesion (GO:0090136)3.26310678
90trivalent inorganic anion homeostasis (GO:0072506)3.26053333
91phosphate ion homeostasis (GO:0055062)3.26053333
92striated muscle atrophy (GO:0014891)3.22047063
93drug transport (GO:0015893)3.19675202
94positive regulation of fatty acid beta-oxidation (GO:0032000)3.17775477
95phosphatidylethanolamine biosynthetic process (GO:0006646)3.13450751
96fat-soluble vitamin biosynthetic process (GO:0042362)3.13279817
97actin filament depolymerization (GO:0030042)3.13020245
98heart valve formation (GO:0003188)3.12086457
99bicarbonate transport (GO:0015701)3.11934370
100positive regulation of triglyceride metabolic process (GO:0090208)3.11739440
101embryonic hemopoiesis (GO:0035162)3.11563050
102DNA methylation involved in gamete generation (GO:0043046)3.10744058
103glutathione biosynthetic process (GO:0006750)3.10188844
104lung epithelium development (GO:0060428)3.09689593
105homocysteine metabolic process (GO:0050667)3.08844997
106heme biosynthetic process (GO:0006783)3.08772734
107bundle of His cell to Purkinje myocyte communication (GO:0086069)3.07449600
108thyroid hormone metabolic process (GO:0042403)3.04072197
109complement activation, alternative pathway (GO:0006957)3.02926378
110regulation of cholesterol metabolic process (GO:0090181)3.01801194
111granulocyte differentiation (GO:0030851)3.01086021
112gonadal mesoderm development (GO:0007506)2.99610173
113negative regulation of thymocyte apoptotic process (GO:0070244)2.99264282
114plasma lipoprotein particle clearance (GO:0034381)2.98932237
115sperm capacitation (GO:0048240)2.98322079
116seminiferous tubule development (GO:0072520)2.97306242
117regulation of guanylate cyclase activity (GO:0031282)2.97007583
118regulation of male gonad development (GO:2000018)2.95307366
119glutamine family amino acid biosynthetic process (GO:0009084)2.95048238
120drug catabolic process (GO:0042737)2.94455385
121maternal placenta development (GO:0001893)2.93226340
122gene silencing by RNA (GO:0031047)2.92778429
123tolerance induction (GO:0002507)2.91693432
124glyoxylate metabolic process (GO:0046487)2.91653724
125erythrocyte development (GO:0048821)2.90938208
126oocyte development (GO:0048599)2.88086667
127male sex determination (GO:0030238)2.87638094
128NADH metabolic process (GO:0006734)2.87424085
129regulation of systemic arterial blood pressure by hormone (GO:0001990)2.87229461
130regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.87229461
131endocrine process (GO:0050886)2.87229461
132phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.86734312
133adhesion of symbiont to host cell (GO:0044650)2.86723963
134virion attachment to host cell (GO:0019062)2.86723963
135lipoprotein metabolic process (GO:0042157)2.86398644
136primary alcohol catabolic process (GO:0034310)2.85967389
137nonribosomal peptide biosynthetic process (GO:0019184)2.85742639
138vitamin transmembrane transport (GO:0035461)2.85642266
139regulation of fatty acid biosynthetic process (GO:0042304)2.84397886
140antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84012363
141antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84012363
142fructose metabolic process (GO:0006000)2.83120614
143bile acid and bile salt transport (GO:0015721)2.82211314
144tetrapyrrole metabolic process (GO:0033013)2.80891312
145blood coagulation, intrinsic pathway (GO:0007597)2.80836801
146regulation of cholesterol biosynthetic process (GO:0045540)2.80787108
147cholesterol homeostasis (GO:0042632)2.80701864
148hypotonic response (GO:0006971)2.80409598
149cellular response to thyroid hormone stimulus (GO:0097067)2.80328293
150negative regulation of DNA-templated transcription, elongation (GO:0032785)2.79172134
151regulation of chromatin binding (GO:0035561)2.79038404
152digestive system process (GO:0022600)2.77071598
153modified amino acid transport (GO:0072337)2.75985347
154peptide catabolic process (GO:0043171)2.75972927
155Peyers patch development (GO:0048541)2.75305516
156mucosal-associated lymphoid tissue development (GO:0048537)2.75305516
157germ cell migration (GO:0008354)2.73914286
158regulation of erythrocyte differentiation (GO:0045646)2.72722336
159adhesion of symbiont to host (GO:0044406)2.72320739
160response to laminar fluid shear stress (GO:0034616)2.69619593
161purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.69352988
1623-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.69352988
163skeletal muscle adaptation (GO:0043501)2.67756270
164regulation of gamma-delta T cell differentiation (GO:0045586)2.67296679
165hormone catabolic process (GO:0042447)2.66727955
166receptor catabolic process (GO:0032801)2.66517874
167regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.64927730
168rRNA catabolic process (GO:0016075)2.64852191
169gene silencing (GO:0016458)2.62760840
170intracellular estrogen receptor signaling pathway (GO:0030520)2.62675269
171male meiosis I (GO:0007141)2.60136923
172diacylglycerol metabolic process (GO:0046339)2.59900993
173chromatin assembly (GO:0031497)2.54779617
174decidualization (GO:0046697)2.53501064
175epithelial structure maintenance (GO:0010669)2.52902194
176hemidesmosome assembly (GO:0031581)2.52121825
177poly(A)+ mRNA export from nucleus (GO:0016973)2.51782959
178calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.50883838
179spermatid development (GO:0007286)2.49024367
180glucose 6-phosphate metabolic process (GO:0051156)2.48135377
181vitamin transport (GO:0051180)2.47946442
182regulation of interleukin-12 biosynthetic process (GO:0045075)2.45577262
183response to thyroid hormone (GO:0097066)2.45299660
184O-glycan processing (GO:0016266)2.43394865
185negative regulation of skeletal muscle tissue development (GO:0048642)2.42566965
186histone H3-K4 trimethylation (GO:0080182)2.42470569
187megakaryocyte development (GO:0035855)2.41584365
188receptor guanylyl cyclase signaling pathway (GO:0007168)2.39456026
189antigen processing and presentation of endogenous antigen (GO:0019883)2.37720010
190mRNA stabilization (GO:0048255)2.35750853
191RNA stabilization (GO:0043489)2.35750853

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.44908871
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.37510424
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.99648955
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.86543351
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61124284
6MYC_22102868_ChIP-Seq_BL_Human2.47853487
7* TCF7_22412390_ChIP-Seq_EML_Mouse2.36343342
8CDX2_20551321_ChIP-Seq_CACO-2_Human2.36155883
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.26977618
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.26371163
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.21296734
12* RACK7_27058665_Chip-Seq_MCF-7_Human2.19418166
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12449233
14VDR_21846776_ChIP-Seq_THP-1_Human2.11387973
15KDM2B_26808549_Chip-Seq_DND41_Human2.09865628
16GATA6_25053715_ChIP-Seq_YYC3_Human2.09352867
17ZNF263_19887448_ChIP-Seq_K562_Human2.08516351
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02717826
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00567127
20LXR_22292898_ChIP-Seq_THP-1_Human1.95118152
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.93974017
22LXR_22158963_ChIP-Seq_LIVER_Mouse1.93709506
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.90643489
24GATA1_22025678_ChIP-Seq_K562_Human1.89957557
25RUNX1_27514584_Chip-Seq_MCF-7_Human1.89229506
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89115899
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.87560139
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.87560139
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.87560139
30* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86209581
31* SMC4_20622854_ChIP-Seq_HELA_Human1.84282133
32ATF3_27146783_Chip-Seq_COLON_Human1.83826173
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79687413
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79031999
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.74911103
36TET1_21451524_ChIP-Seq_MESCs_Mouse1.72151931
37* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.71459298
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.70679432
39* ELK3_25401928_ChIP-Seq_HUVEC_Human1.70181281
40* MAF_26560356_Chip-Seq_TH1_Human1.67144762
41* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.67099707
42GATA4_25053715_ChIP-Seq_YYC3_Human1.65519279
43* CREB1_26743006_Chip-Seq_LNCaP_Human1.65137496
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61482703
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.60835227
46* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59458361
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56481929
48* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55118453
49* SA1_27219007_Chip-Seq_Bcells_Human1.52731470
50UTX_26944678_Chip-Seq_JUKART_Human1.52158799
51* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50351553
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.50107135
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49459926
54TP53_22127205_ChIP-Seq_IMR90_Human1.49322556
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48956114
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47677549
57P68_20966046_ChIP-Seq_HELA_Human1.47063413
58* NCOR1_26117541_ChIP-Seq_K562_Human1.46323096
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43612595
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.43289346
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43246593
62GATA1_19941826_ChIP-Seq_K562_Human1.42322327
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41320074
64* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39868773
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38012367
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36456047
67* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36080369
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35370692
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35166825
70CTCF_20526341_ChIP-Seq_ESCs_Human1.34832392
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34240889
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34005454
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33596664
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33015033
75TP63_22573176_ChIP-Seq_HFKS_Human1.31439830
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31363588
77GATA2_19941826_ChIP-Seq_K562_Human1.29697410
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29344893
79* KDM2B_26808549_Chip-Seq_K562_Human1.27896553
80BCOR_27268052_Chip-Seq_Bcells_Human1.27744023
81PPARA_22158963_ChIP-Seq_LIVER_Mouse1.27278682
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27090220
83KLF5_25053715_ChIP-Seq_YYC3_Human1.26960119
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26892166
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26344762
86VDR_24763502_ChIP-Seq_THP-1_Human1.26250988
87* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25414916
88* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25109629
89MAF_26560356_Chip-Seq_TH2_Human1.24448001
90* GATA1_19941827_ChIP-Seq_MEL_Mouse1.22909168
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21894052
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21646085
93* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21374179
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.21202690
95* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20019932
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19966850
97PHF8_20622854_ChIP-Seq_HELA_Human1.18531785
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.18471979
99* SA1_27219007_Chip-Seq_ERYTHROID_Human1.17937394
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17733363
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17554110
102FOXM1_23109430_ChIP-Seq_U2OS_Human1.17243290
103CLOCK_20551151_ChIP-Seq_293T_Human1.17140649
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.17089019
105BCL6_27268052_Chip-Seq_Bcells_Human1.17081174
106* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16716701
107* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16313199
108GATA1_26923725_Chip-Seq_HPCs_Mouse1.15856126
109SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15719698
110JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.13897531
111* RUNX1_22412390_ChIP-Seq_EML_Mouse1.13284881
112ERA_21632823_ChIP-Seq_H3396_Human1.13241804
113P300_27268052_Chip-Seq_Bcells_Human1.12944428
114RARB_24833708_ChIP-Seq_LIVER_Mouse1.12418562
115MYB_26560356_Chip-Seq_TH1_Human1.12050615
116P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11741021
117ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10198105
118E2F1_20622854_ChIP-Seq_HELA_Human1.10087215
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09661182
120ESR1_20079471_ChIP-ChIP_T-47D_Human1.07123521
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05881903
122DROSHA_22980978_ChIP-Seq_HELA_Human1.05855514
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05344696
124RARA_24833708_ChIP-Seq_LIVER_Mouse1.05183507
125BP1_19119308_ChIP-ChIP_Hs578T_Human1.04519662
126* KDM2B_26808549_Chip-Seq_JURKAT_Human1.04467162
127* CTCF_21964334_Chip-Seq_Bcells_Human1.04337537
128STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03560806
129ESR2_21235772_ChIP-Seq_MCF-7_Human1.02005763
130PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01257895
131* HNF4A_19822575_ChIP-Seq_HepG2_Human1.01242385
132* CTCF_27219007_Chip-Seq_Bcells_Human1.00133458
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99684277
134* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98325078
135SCL_19346495_ChIP-Seq_HPC-7_Human0.96827213
136RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96760854
137* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96723976
138EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96000198
139OCT4_19829295_ChIP-Seq_ESCs_Human0.95563360
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95501017
141NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94945814
142RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94867200
143KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93929953
144* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93509559
145* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91948287

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.30938537
2* MP0005377_hearing/vestibular/ear_phenot4.22418219
3* MP0003878_abnormal_ear_physiology4.22418219
4MP0005085_abnormal_gallbladder_physiolo3.67557906
5MP0010234_abnormal_vibrissa_follicle3.65727514
6MP0003300_gastrointestinal_ulcer3.60595385
7MP0005365_abnormal_bile_salt3.54308964
8MP0003656_abnormal_erythrocyte_physiolo3.52268953
9MP0005083_abnormal_biliary_tract3.51458866
10MP0004264_abnormal_extraembryonic_tissu3.13822818
11MP0008877_abnormal_DNA_methylation2.96706005
12* MP0003866_abnormal_defecation2.95977303
13MP0008995_early_reproductive_senescence2.95944233
14MP0010352_gastrointestinal_tract_polyps2.89529465
15MP0001666_abnormal_nutrient_absorption2.73507362
16MP0009379_abnormal_foot_pigmentation2.53055580
17MP0000566_synostosis2.49907820
18MP0005410_abnormal_fertilization2.39114732
19MP0003283_abnormal_digestive_organ2.30524282
20MP0003705_abnormal_hypodermis_morpholog2.28731603
21MP0000490_abnormal_crypts_of2.16955838
22MP0001873_stomach_inflammation2.12687016
23MP0010155_abnormal_intestine_physiology2.06688995
24MP0001849_ear_inflammation1.93496791
25MP0002653_abnormal_ependyma_morphology1.89972801
26MP0005310_abnormal_salivary_gland1.88676907
27MP0000537_abnormal_urethra_morphology1.87098462
28MP0003195_calcinosis1.76784668
29MP0004043_abnormal_pH_regulation1.74441169
30MP0000477_abnormal_intestine_morphology1.71089332
31MP0000678_abnormal_parathyroid_gland1.69671141
32MP0003252_abnormal_bile_duct1.67545378
33MP0005076_abnormal_cell_differentiation1.64377088
34MP0002132_abnormal_respiratory_system1.64296312
35MP0009278_abnormal_bone_marrow1.59687197
36MP0003122_maternal_imprinting1.59650085
37MP0002876_abnormal_thyroid_physiology1.58369571
38MP0008961_abnormal_basal_metabolism1.53106473
39MP0001663_abnormal_digestive_system1.51172406
40MP0005332_abnormal_amino_acid1.49392878
41MP0001188_hyperpigmentation1.48382000
42MP0003123_paternal_imprinting1.43102531
43MP0003183_abnormal_peptide_metabolism1.41293990
44MP0001545_abnormal_hematopoietic_system1.40579742
45MP0005397_hematopoietic_system_phenotyp1.40579742
46MP0002138_abnormal_hepatobiliary_system1.40500182
47MP0004019_abnormal_vitamin_homeostasis1.39485916
48MP0002254_reproductive_system_inflammat1.36595248
49MP0005409_darkened_coat_color1.36233033
50MP0003045_fibrosis1.34154844
51MP0005381_digestive/alimentary_phenotyp1.33022956
52MP0000462_abnormal_digestive_system1.31975163
53MP0002822_catalepsy1.31860419
54MP0002118_abnormal_lipid_homeostasis1.30936090
55MP0001929_abnormal_gametogenesis1.30583953
56MP0003191_abnormal_cellular_cholesterol1.28346791
57MP0003315_abnormal_perineum_morphology1.27562008
58MP0004147_increased_porphyrin_level1.26416387
59MP0003698_abnormal_male_reproductive1.24266180
60MP0002210_abnormal_sex_determination1.23154587
61MP0001145_abnormal_male_reproductive1.22925643
62MP0005167_abnormal_blood-brain_barrier1.22914887
63MP0003329_amyloid_beta_deposits1.21836571
64MP0003436_decreased_susceptibility_to1.20211528
65MP0002009_preneoplasia1.16386606
66MP0005451_abnormal_body_composition1.14475630
67MP0002249_abnormal_larynx_morphology1.14073389
68MP0004858_abnormal_nervous_system1.12463461
69MP0001765_abnormal_ion_homeostasis1.10732439
70MP0003786_premature_aging1.10548954
71MP0003763_abnormal_thymus_physiology1.09373681
72MP0004947_skin_inflammation1.08321019
73MP0002796_impaired_skin_barrier1.06389151
74MP0003453_abnormal_keratinocyte_physiol1.05943365
75MP0009643_abnormal_urine_homeostasis1.05936460
76MP0008875_abnormal_xenobiotic_pharmacok1.04939143
77MP0009840_abnormal_foam_cell1.04624545
78MP0003638_abnormal_response/metabolism_1.04313547
79MP0010307_abnormal_tumor_latency1.01900889
80MP0005501_abnormal_skin_physiology0.99407864
81MP0000470_abnormal_stomach_morphology0.98810608
82MP0002089_abnormal_postnatal_growth/wei0.94931107
83MP0008872_abnormal_physiological_respon0.94502982
84MP0003011_delayed_dark_adaptation0.94159116
85MP0003172_abnormal_lysosome_physiology0.94054783
86MP0000653_abnormal_sex_gland0.93359964
87MP0001664_abnormal_digestion0.90883113
88MP0002136_abnormal_kidney_physiology0.88612820
89MP0003941_abnormal_skin_development0.88337702
90MP0009333_abnormal_splenocyte_physiolog0.87786985
91MP0001730_embryonic_growth_arrest0.87028325
92MP0002086_abnormal_extraembryonic_tissu0.86725169
93MP0000467_abnormal_esophagus_morphology0.86042593
94MP0001764_abnormal_homeostasis0.84622803
95MP0005319_abnormal_enzyme/_coenzyme0.84207008
96MP0004957_abnormal_blastocyst_morpholog0.82126017
97MP0003115_abnormal_respiratory_system0.81345191
98MP0009642_abnormal_blood_homeostasis0.79523908
99MP0006054_spinal_hemorrhage0.78791631
100MP0001485_abnormal_pinna_reflex0.78673731
101MP0005636_abnormal_mineral_homeostasis0.77901578
102MP0001348_abnormal_lacrimal_gland0.76852394
103MP0001727_abnormal_embryo_implantation0.75834191
104MP0003936_abnormal_reproductive_system0.75366417
105MP0010678_abnormal_skin_adnexa0.75288819
106MP0010329_abnormal_lipoprotein_level0.74458510
107MP0001216_abnormal_epidermal_layer0.72491113
108MP0003119_abnormal_digestive_system0.72062062
109MP0000598_abnormal_liver_morphology0.71938997
110MP0005075_abnormal_melanosome_morpholog0.71276576
111MP0004185_abnormal_adipocyte_glucose0.70980355
112MP0000604_amyloidosis0.70646200
113MP0001756_abnormal_urination0.70625090
114MP0000538_abnormal_urinary_bladder0.70341136
115MP0002161_abnormal_fertility/fecundity0.70173035
116MP0003693_abnormal_embryo_hatching0.69952105
117MP0005448_abnormal_energy_balance0.69818429
118MP0004782_abnormal_surfactant_physiolog0.69383894
119MP0005670_abnormal_white_adipose0.69082263
120MP0003111_abnormal_nucleus_morphology0.68503501
121MP0008260_abnormal_autophagy0.68139815
122MP0006082_CNS_inflammation0.67811759
123MP0002166_altered_tumor_susceptibility0.67547522
124MP0004381_abnormal_hair_follicle0.67490910
125* MP0003879_abnormal_hair_cell0.66473585
126MP0000015_abnormal_ear_pigmentation0.65906928
127MP0002139_abnormal_hepatobiliary_system0.65631875
128MP0005023_abnormal_wound_healing0.65500287
129MP0009115_abnormal_fat_cell0.65422748
130MP0003566_abnormal_cell_adhesion0.62915646
131MP0000858_altered_metastatic_potential0.62573449
132MP0000609_abnormal_liver_physiology0.62476761
133MP0009384_cardiac_valve_regurgitation0.62333397
134MP0002405_respiratory_system_inflammati0.61768010
135MP0005666_abnormal_adipose_tissue0.61561291
136MP0005058_abnormal_lysosome_morphology0.60750071
137MP0002084_abnormal_developmental_patter0.60448715
138MP0001881_abnormal_mammary_gland0.59823867
139MP0001697_abnormal_embryo_size0.59657445
140MP0004197_abnormal_fetal_growth/weight/0.58965376
141MP0009931_abnormal_skin_appearance0.58666903
142MP0009780_abnormal_chondrocyte_physiolo0.58138455
143MP0002722_abnormal_immune_system0.57915350
144MP0000685_abnormal_immune_system0.57329137
145MP0002098_abnormal_vibrissa_morphology0.56895964
146MP0003868_abnormal_feces_composition0.56251008
147MP0002135_abnormal_kidney_morphology0.56158994
148MP0003953_abnormal_hormone_level0.54086219
149MP0002078_abnormal_glucose_homeostasis0.51156313
150MP0000377_abnormal_hair_follicle0.50059485
151MP0005025_abnormal_response_to0.48857603
152MP0004133_heterotaxia0.48304642
153MP0005408_hypopigmentation0.48049699
154MP0000367_abnormal_coat/_hair0.47252252

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.45472164
2Acanthocytosis (HP:0001927)5.17282308
3Abnormal hemoglobin (HP:0011902)5.09724436
4Male infertility (HP:0003251)4.57385419
5Hypochromic microcytic anemia (HP:0004840)4.28095676
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.27426003
7Malnutrition (HP:0004395)4.17224601
8Petechiae (HP:0000967)4.02403312
9Hypochromic anemia (HP:0001931)3.97013058
10Prolonged partial thromboplastin time (HP:0003645)3.95149996
11Polycythemia (HP:0001901)3.93150197
12Xanthomatosis (HP:0000991)3.84655036
13Hypobetalipoproteinemia (HP:0003563)3.75008961
14Hemorrhage of the eye (HP:0011885)3.71494046
15Flat acetabular roof (HP:0003180)3.64680526
16Reticulocytosis (HP:0001923)3.55801142
17Hand muscle atrophy (HP:0009130)3.54291934
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.52172343
19Complement deficiency (HP:0004431)3.48609070
20Poikilocytosis (HP:0004447)3.44336730
21Nasal polyposis (HP:0100582)3.39943181
22Microcytic anemia (HP:0001935)3.33326058
23Ileus (HP:0002595)3.26483971
24Joint hemorrhage (HP:0005261)3.19481473
25Right ventricular cardiomyopathy (HP:0011663)3.09707648
26Hydroxyprolinuria (HP:0003080)3.05341045
27Abnormality of proline metabolism (HP:0010907)3.05341045
28Mesangial abnormality (HP:0001966)3.03436741
29Broad palm (HP:0001169)3.02003590
30Metaphyseal cupping (HP:0003021)3.01865009
31Hyperactive renin-angiotensin system (HP:0000841)3.01626928
32Systemic lupus erythematosus (HP:0002725)3.00393081
33Osteomalacia (HP:0002749)3.00160149
34Abnormality of the nasal mucosa (HP:0000433)2.91902457
35Abnormality of chloride homeostasis (HP:0011422)2.90143310
36Abnormal respiratory motile cilium morphology (HP:0005938)2.89864738
37Abnormal respiratory epithelium morphology (HP:0012253)2.89864738
38Abnormality of complement system (HP:0005339)2.89351138
39Chronic diarrhea (HP:0002028)2.85687297
40Diaphragmatic weakness (HP:0009113)2.83932810
41Autoimmune thrombocytopenia (HP:0001973)2.82550919
42Cholelithiasis (HP:0001081)2.80064743
43Gonadotropin excess (HP:0000837)2.79632670
44Pustule (HP:0200039)2.75224994
45Gonadal dysgenesis (HP:0000133)2.75003345
46Abnormality of small intestinal villus morphology (HP:0011472)2.74953264
47Villous atrophy (HP:0011473)2.74953264
48Gastrointestinal infarctions (HP:0005244)2.74076721
49Abdominal distention (HP:0003270)2.73519697
50Abnormal respiratory motile cilium physiology (HP:0012261)2.68716258
51Distal upper limb amyotrophy (HP:0007149)2.68666610
52Upper limb amyotrophy (HP:0009129)2.68666610
53Abnormality of aromatic amino acid family metabolism (HP:0004338)2.66669290
54Hyperbilirubinemia (HP:0002904)2.64506307
55Increased density of long bones (HP:0006392)2.64434027
56Rectal prolapse (HP:0002035)2.64391830
57Abnormality of the fingertips (HP:0001211)2.64131600
58Milia (HP:0001056)2.63548533
59Tongue fasciculations (HP:0001308)2.62569227
60Glomerulonephritis (HP:0000099)2.60230142
61Impaired platelet aggregation (HP:0003540)2.59308747
62Abnormal platelet function (HP:0011869)2.59308747
63Rhinitis (HP:0012384)2.58867702
64Cupped ribs (HP:0000887)2.55840555
65Abnormal ciliary motility (HP:0012262)2.54785146
66Pili torti (HP:0003777)2.51988977
67Abnormality of the 1st metacarpal (HP:0010009)2.47687852
68Metabolic alkalosis (HP:0200114)2.45898634
69Hypophosphatemia (HP:0002148)2.42463136
70Micronodular cirrhosis (HP:0001413)2.41806918
71Abnormal urine phosphate concentration (HP:0012599)2.41357663
72Abnormality of reticulocytes (HP:0004312)2.41215774
73Abnormality of the distal phalanx of the thumb (HP:0009617)2.40852764
74Hyperacusis (HP:0010780)2.37354963
75Rickets (HP:0002748)2.36895082
76Thin bony cortex (HP:0002753)2.36240307
77Abnormal gallbladder morphology (HP:0012437)2.36049195
78Short phalanx of the thumb (HP:0009660)2.35172826
79Hyperphosphaturia (HP:0003109)2.34953816
80Muscle fibrillation (HP:0010546)2.34449287
81Myopathic facies (HP:0002058)2.32998154
82Short middle phalanx of the 5th finger (HP:0004220)2.32130512
83Autoimmune hemolytic anemia (HP:0001890)2.28452006
84Cerebral palsy (HP:0100021)2.27890661
85Stridor (HP:0010307)2.25377063
86Hyperglycinuria (HP:0003108)2.21755759
87Hypercholesterolemia (HP:0003124)2.20963309
88Abnormality of the lower motor neuron (HP:0002366)2.20675302
89Confusion (HP:0001289)2.19714748
90Pallor (HP:0000980)2.19388368
91Mildly elevated creatine phosphokinase (HP:0008180)2.18659561
92Abnormality of pyrimidine metabolism (HP:0004353)2.15609468
93Facial diplegia (HP:0001349)2.15134586
94Abnormality of glycine metabolism (HP:0010895)2.14685234
95Abnormality of serine family amino acid metabolism (HP:0010894)2.14685234
96Abnormality of the gastric mucosa (HP:0004295)2.11582891
9711 pairs of ribs (HP:0000878)2.10046699
98Infertility (HP:0000789)2.09746333
99Abnormal gallbladder physiology (HP:0012438)2.07991320
100Cholecystitis (HP:0001082)2.07991320
101Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.05067156
102Hyperparathyroidism (HP:0000843)2.04211360
103Widely patent fontanelles and sutures (HP:0004492)2.04097306
104Hepatocellular carcinoma (HP:0001402)2.04022329
105Abnormality of the gallbladder (HP:0005264)2.03333354
106Ependymoma (HP:0002888)2.03281988
107Potter facies (HP:0002009)2.02703679
108Facial shape deformation (HP:0011334)2.02703679
109Gout (HP:0001997)1.98564593
110Azoospermia (HP:0000027)1.97694694
111Hypercalciuria (HP:0002150)1.96773059
112Growth hormone excess (HP:0000845)1.95671192
113Hypolipoproteinemia (HP:0010981)1.94036963
114Short middle phalanx of finger (HP:0005819)1.93806016
115Hypophosphatemic rickets (HP:0004912)1.93348020
116Abnormality of transition element cation homeostasis (HP:0011030)1.92797120
117Increased serum ferritin (HP:0003281)1.92539151
118Hypoplastic iliac wings (HP:0002866)1.92128313
119Fat malabsorption (HP:0002630)1.91898823
120Alkalosis (HP:0001948)1.91780884
121Conjugated hyperbilirubinemia (HP:0002908)1.91780554
122Increased IgE level (HP:0003212)1.91186528
123Pigmentary retinal degeneration (HP:0001146)1.90756597
124Glycosuria (HP:0003076)1.89512529
125Abnormality of urine glucose concentration (HP:0011016)1.89512529
126Posterior subcapsular cataract (HP:0007787)1.89456706
127Hyponatremia (HP:0002902)1.88575378
128Germ cell neoplasia (HP:0100728)1.87486725
129Abnormality of iron homeostasis (HP:0011031)1.85855015
130Short 5th finger (HP:0009237)1.83677430
131Enlarged kidneys (HP:0000105)1.83417856
132Purpura (HP:0000979)1.82324121
133Biliary tract neoplasm (HP:0100574)1.81908972
134Paralysis (HP:0003470)1.81735543
135Hyperammonemia (HP:0001987)1.81491513
136Abnormality of male internal genitalia (HP:0000022)1.80997555
137Gastrointestinal inflammation (HP:0004386)1.79296480
138Renal tubular acidosis (HP:0001947)1.78146349
139Delayed CNS myelination (HP:0002188)1.78066560
140Testicular neoplasm (HP:0010788)1.77292293
141Seborrheic dermatitis (HP:0001051)1.76181536
142Abnormality of the heme biosynthetic pathway (HP:0010472)1.75040655
143Hyperlipoproteinemia (HP:0010980)1.74513187
144Inflammation of the large intestine (HP:0002037)1.74090614
145Menorrhagia (HP:0000132)1.73438184
146IgM deficiency (HP:0002850)1.71396165
147Abnormality of the musculature of the hand (HP:0001421)1.69022101
148Shawl scrotum (HP:0000049)1.68519784
149Dehydration (HP:0001944)1.67829720
150Difficulty climbing stairs (HP:0003551)1.67343398
151Abnormal hair laboratory examination (HP:0003328)1.67301826
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.65079727
153Absent/shortened dynein arms (HP:0200106)1.65079727
154Nephrolithiasis (HP:0000787)1.64999031
155Goiter (HP:0000853)1.62552137
156Chronic bronchitis (HP:0004469)1.61421772
157Male pseudohermaphroditism (HP:0000037)1.60838565
158Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.60533958
159Combined immunodeficiency (HP:0005387)1.60390496
160Abnormality of renal excretion (HP:0011036)1.60236000
161Abnormality of renin-angiotensin system (HP:0000847)1.60184719
162Colitis (HP:0002583)1.58625205
163Fasciculations (HP:0002380)1.57549559
164Hypoplasia of dental enamel (HP:0006297)1.57532653

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.32307850
2MAP3K103.53864231
3MST1R3.50272113
4ICK3.22879641
5MST42.97084004
6SIK12.78478119
7MAP2K22.75402771
8EIF2AK12.74291282
9TRIB32.50121924
10SMG12.44953523
11EEF2K2.36089590
12GRK62.35725689
13SIK22.08816300
14TYRO32.02946298
15PIK3CA1.97385716
16MAP4K11.95157153
17PTK61.92832051
18WNK41.88299794
19PKN21.78522894
20STK101.77572333
21MAPKAPK31.77170640
22TESK21.77074362
23TESK11.75602046
24EPHA21.66754912
25TAOK11.64415396
26DMPK1.63374973
27RPS6KA21.59696303
28RIPK11.51363076
29PAK41.46911875
30EPHB11.44548342
31NEK21.43425562
32MAP3K71.42261370
33MUSK1.38470740
34TLK11.34369940
35PRPF4B1.31472111
36LMTK21.30043197
37ERN11.28980111
38DYRK1B1.23753912
39PDK31.21943832
40PDK41.21943832
41CDK91.18116579
42NUAK11.16960018
43NME11.14833899
44PRKD31.14552913
45MARK21.12689250
46MAP3K21.12301551
47BMX1.12232676
48MET1.10980570
49RPS6KC11.10321649
50RPS6KL11.10321649
51PRKG21.08891254
52PTK21.07854016
53RPS6KA61.01350613
54EPHB21.01078054
55MATK1.00358527
56MTOR0.96321316
57PRKD20.94496966
58MAP3K80.93190707
59PDPK10.93043587
60CDK70.91728764
61FRK0.91530545
62TTK0.91288488
63HIPK20.91024142
64TAOK20.90661499
65LATS10.88599352
66CDK40.85395622
67LRRK20.84375220
68FGFR30.83661021
69WNK10.82643880
70NEK10.82236629
71CSK0.81642681
72PAK20.81608516
73SCYL20.78787116
74FGFR40.78613402
75STK38L0.78432017
76DDR20.77848011
77MAP3K110.77510065
78BRD40.75779778
79DYRK30.75296979
80CDK60.75187448
81CHUK0.74872514
82CDC70.72458059
83RPS6KB20.70980422
84SGK30.70493852
85KSR20.69984933
86MAP2K60.69026710
87SGK4940.68675312
88SGK2230.68675312
89IKBKB0.66374081
90MAPK150.66056321
91IRAK30.65413729
92PIM10.64368156
93WNK30.64303901
94ALK0.64278188
95PRKCI0.63957462
96CDC42BPA0.63641360
97STK30.62672996
98PRKAA20.61214754
99ITK0.61187821
100PDK10.60455312
101MYLK0.60302800
102PTK2B0.59511341
103CAMK1G0.58557318
104STK380.57159134
105PRKCZ0.57143101
106ERBB20.55714550
107MAP3K10.54993245
108MAPKAPK20.53544327
109ACVR1B0.52918667
110DYRK20.52892077
111SGK10.51962390
112CAMKK10.50813204
113FER0.50155061
114RPS6KA10.48832367
115ZAP700.48195821
116TXK0.46021627
117MAP2K30.45437096
118RIPK40.45434770
119MAP2K10.45302498
120NEK60.44594317
121IKBKE0.43496815
122EPHA30.43467646
123PDGFRA0.43443314
124PDK20.43003698
125MAP3K30.42795923
126AKT20.42300887
127TYK20.42158266
128MAPK110.41797125
129TNK20.41654557
130TBK10.41537842
131PDGFRB0.41440737
132TAOK30.41216240
133GSK3A0.40070384
134RET0.38874029
135CHEK10.38462562
136PIM20.35294881
137PAK10.35017774
138CAMK1D0.33887878
139MAPK30.33851763
140BRAF0.33181608
141PRKACG0.31428267
142RPS6KB10.30857384
143SGK20.28677240
144PRKCD0.27563035
145STK110.27509048

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.43616559
2Mineral absorption_Homo sapiens_hsa049784.09247061
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.58403216
4Vitamin digestion and absorption_Homo sapiens_hsa049773.25618800
5Renin-angiotensin system_Homo sapiens_hsa046142.95979935
6Arginine biosynthesis_Homo sapiens_hsa002202.89047058
7Phenylalanine metabolism_Homo sapiens_hsa003602.86966121
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83401375
9Sulfur metabolism_Homo sapiens_hsa009202.77568432
10Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.76114681
11Chemical carcinogenesis_Homo sapiens_hsa052042.35511382
12Protein digestion and absorption_Homo sapiens_hsa049742.35383155
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.32875676
14Complement and coagulation cascades_Homo sapiens_hsa046102.31208226
15Carbohydrate digestion and absorption_Homo sapiens_hsa049732.26658263
16Retinol metabolism_Homo sapiens_hsa008302.23159795
17Galactose metabolism_Homo sapiens_hsa000522.15414994
18Bile secretion_Homo sapiens_hsa049762.05258380
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.99050525
20Fructose and mannose metabolism_Homo sapiens_hsa000511.92374676
21Tyrosine metabolism_Homo sapiens_hsa003501.90693851
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.78778156
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.68305660
24Glycerolipid metabolism_Homo sapiens_hsa005611.65771636
25Lysine degradation_Homo sapiens_hsa003101.61046595
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54996616
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.54978321
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.46571123
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.42250745
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40947411
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.39863348
32Tight junction_Homo sapiens_hsa045301.38837796
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34294338
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.34101891
35Starch and sucrose metabolism_Homo sapiens_hsa005001.33288511
36Arginine and proline metabolism_Homo sapiens_hsa003301.32738391
37Sulfur relay system_Homo sapiens_hsa041221.21111165
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18893177
39Pyruvate metabolism_Homo sapiens_hsa006201.18372498
40Adherens junction_Homo sapiens_hsa045201.17722892
41PPAR signaling pathway_Homo sapiens_hsa033201.15220581
42Bladder cancer_Homo sapiens_hsa052191.14199553
43Peroxisome_Homo sapiens_hsa041461.13477353
44Dorso-ventral axis formation_Homo sapiens_hsa043201.11829898
45Thyroid cancer_Homo sapiens_hsa052161.10893007
46Glutathione metabolism_Homo sapiens_hsa004801.08431993
47Pentose phosphate pathway_Homo sapiens_hsa000301.08024384
48Toxoplasmosis_Homo sapiens_hsa051451.03139047
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.02739231
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00321306
51Small cell lung cancer_Homo sapiens_hsa052220.99054594
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.97705758
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.97356410
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96975827
55Linoleic acid metabolism_Homo sapiens_hsa005910.93944004
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90855207
57Thyroid hormone synthesis_Homo sapiens_hsa049180.89104349
58Fatty acid metabolism_Homo sapiens_hsa012120.87404581
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86013336
60Acute myeloid leukemia_Homo sapiens_hsa052210.85257902
61Biosynthesis of amino acids_Homo sapiens_hsa012300.83547178
62Chronic myeloid leukemia_Homo sapiens_hsa052200.79872605
63VEGF signaling pathway_Homo sapiens_hsa043700.79085395
64Nitrogen metabolism_Homo sapiens_hsa009100.78115061
65T cell receptor signaling pathway_Homo sapiens_hsa046600.76990772
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76855956
67ABC transporters_Homo sapiens_hsa020100.76206815
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76198243
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74214244
70Pancreatic secretion_Homo sapiens_hsa049720.72100214
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68475131
72Fatty acid biosynthesis_Homo sapiens_hsa000610.68116158
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.66485593
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66404866
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66140523
76Gastric acid secretion_Homo sapiens_hsa049710.65451838
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.65192735
78Carbon metabolism_Homo sapiens_hsa012000.63376303
79Butanoate metabolism_Homo sapiens_hsa006500.61558781
80Antigen processing and presentation_Homo sapiens_hsa046120.61453946
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61154162
82Fatty acid degradation_Homo sapiens_hsa000710.60346710
83Notch signaling pathway_Homo sapiens_hsa043300.58288178
84Endometrial cancer_Homo sapiens_hsa052130.56938654
85mRNA surveillance pathway_Homo sapiens_hsa030150.56247547
86Influenza A_Homo sapiens_hsa051640.56166735
87AMPK signaling pathway_Homo sapiens_hsa041520.55478828
88Insulin resistance_Homo sapiens_hsa049310.55091508
89Salmonella infection_Homo sapiens_hsa051320.54852155
90Amoebiasis_Homo sapiens_hsa051460.54471207
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.53289086
92Other glycan degradation_Homo sapiens_hsa005110.53047747
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51256779
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51217962
95Caffeine metabolism_Homo sapiens_hsa002320.51060104
96HIF-1 signaling pathway_Homo sapiens_hsa040660.50917627
97Primary immunodeficiency_Homo sapiens_hsa053400.50317857
98Prion diseases_Homo sapiens_hsa050200.50199075
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49922532
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49130073
101TGF-beta signaling pathway_Homo sapiens_hsa043500.47338138
102Pancreatic cancer_Homo sapiens_hsa052120.43825015
103Histidine metabolism_Homo sapiens_hsa003400.43195331
104beta-Alanine metabolism_Homo sapiens_hsa004100.43006289
105Herpes simplex infection_Homo sapiens_hsa051680.42722458
106Hepatitis C_Homo sapiens_hsa051600.40705577
107Leishmaniasis_Homo sapiens_hsa051400.40308903
108Metabolic pathways_Homo sapiens_hsa011000.39817703
109ECM-receptor interaction_Homo sapiens_hsa045120.38941590
110Proteoglycans in cancer_Homo sapiens_hsa052050.38848470
111Hippo signaling pathway_Homo sapiens_hsa043900.38762482
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36977371
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36826216
114Prolactin signaling pathway_Homo sapiens_hsa049170.36758163
115Osteoclast differentiation_Homo sapiens_hsa043800.36449137
116Focal adhesion_Homo sapiens_hsa045100.36033218
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35497850
118Choline metabolism in cancer_Homo sapiens_hsa052310.35206282
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.35025939
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34942691
121Ether lipid metabolism_Homo sapiens_hsa005650.34249838
122Arachidonic acid metabolism_Homo sapiens_hsa005900.34176210
123Tryptophan metabolism_Homo sapiens_hsa003800.33705639
124Apoptosis_Homo sapiens_hsa042100.32865673
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32578218
126Viral myocarditis_Homo sapiens_hsa054160.31209112
127Staphylococcus aureus infection_Homo sapiens_hsa051500.31198391
128Inositol phosphate metabolism_Homo sapiens_hsa005620.30812027
129Pathways in cancer_Homo sapiens_hsa052000.30645854
130Non-small cell lung cancer_Homo sapiens_hsa052230.30442044
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30322772
132Shigellosis_Homo sapiens_hsa051310.29932124
133HTLV-I infection_Homo sapiens_hsa051660.29889804
134Salivary secretion_Homo sapiens_hsa049700.28992452
135Selenocompound metabolism_Homo sapiens_hsa004500.28671036
136Malaria_Homo sapiens_hsa051440.28493441
137Glucagon signaling pathway_Homo sapiens_hsa049220.27384406
138Sphingolipid metabolism_Homo sapiens_hsa006000.24385156
139N-Glycan biosynthesis_Homo sapiens_hsa005100.24129821
140Insulin signaling pathway_Homo sapiens_hsa049100.22996227
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22345016
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19994196
143African trypanosomiasis_Homo sapiens_hsa051430.17302907
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16012027

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