ESPNL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1inflammatory response to antigenic stimulus (GO:0002437)7.75424702
2axoneme assembly (GO:0035082)7.37896005
3virion attachment to host cell (GO:0019062)7.28940401
4adhesion of symbiont to host cell (GO:0044650)7.28940401
5regulation of B cell receptor signaling pathway (GO:0050855)7.21914330
6adhesion of symbiont to host (GO:0044406)6.88928563
7biotin metabolic process (GO:0006768)6.79114781
8I-kappaB phosphorylation (GO:0007252)6.56893362
9negative regulation of viral genome replication (GO:0045071)5.93989076
10epithelial cilium movement (GO:0003351)5.91677549
11negative regulation of T cell receptor signaling pathway (GO:0050860)5.88620892
12negative regulation of fibroblast apoptotic process (GO:2000270)5.86252382
13nucleoside diphosphate phosphorylation (GO:0006165)5.70082873
14mannose metabolic process (GO:0006013)5.61619226
15auditory behavior (GO:0031223)5.47519673
16wound healing, spreading of epidermal cells (GO:0035313)5.27539300
17postsynaptic membrane organization (GO:0001941)5.26149053
18protein carboxylation (GO:0018214)5.25754958
19peptidyl-glutamic acid carboxylation (GO:0017187)5.25754958
20positive regulation of heat generation (GO:0031652)5.22754051
21spindle assembly involved in mitosis (GO:0090307)5.05916505
22negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.89287602
23pinocytosis (GO:0006907)4.87396213
24JAK-STAT cascade (GO:0007259)4.79935809
25vocalization behavior (GO:0071625)4.74565202
26regulation of fibroblast apoptotic process (GO:2000269)4.62340718
27regulation of apoptotic cell clearance (GO:2000425)4.60547890
28regulation of protein glycosylation (GO:0060049)4.49401737
29mechanosensory behavior (GO:0007638)4.38080114
30CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.29945074
31regulation of T cell receptor signaling pathway (GO:0050856)4.25526919
32positive regulation of cellular amide metabolic process (GO:0034250)3.99999291
33negative regulation of glycoprotein biosynthetic process (GO:0010561)3.98183195
34apoptotic cell clearance (GO:0043277)3.96030281
35wound healing, spreading of cells (GO:0044319)3.92722172
36regulation of heat generation (GO:0031650)3.92145880
37glycosphingolipid catabolic process (GO:0046479)3.90102495
38radial glial cell differentiation (GO:0060019)3.84972777
39cilium movement (GO:0003341)3.82781174
40positive regulation of granulocyte differentiation (GO:0030854)3.81146555
41sphingosine metabolic process (GO:0006670)3.77160112
42planar cell polarity pathway involved in neural tube closure (GO:0090179)3.74694942
43cellular response to exogenous dsRNA (GO:0071360)3.73699240
44cellular response to zinc ion (GO:0071294)3.73498572
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67000213
46negative regulation of type 2 immune response (GO:0002829)3.63300029
47regulation of natural killer cell activation (GO:0032814)3.59388321
48positive regulation of protein kinase C signaling (GO:0090037)3.59284599
49regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.57164342
50stress fiber assembly (GO:0043149)3.56503353
51facial nerve structural organization (GO:0021612)3.53857185
52adenosine receptor signaling pathway (GO:0001973)3.53279747
53sphingoid metabolic process (GO:0046519)3.52484180
54UV protection (GO:0009650)3.52409193
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.51500226
56regulation of viral genome replication (GO:0045069)3.46235935
57negative regulation of interleukin-17 production (GO:0032700)3.44986227
58positive regulation of isotype switching (GO:0045830)3.44833210
59response to auditory stimulus (GO:0010996)3.42869055
60glycolipid catabolic process (GO:0019377)3.42843651
61positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.42180674
62modulation by virus of host morphology or physiology (GO:0019048)3.39331772
63homeostasis of number of cells within a tissue (GO:0048873)3.38545104
64response to peptidoglycan (GO:0032494)3.38453248
65regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.33051124
66glucosamine-containing compound catabolic process (GO:1901072)3.31470526
67microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.31398920
68respiratory burst (GO:0045730)3.27499951
69positive thymic T cell selection (GO:0045059)3.24875628
70diol metabolic process (GO:0034311)3.23633428
71GDP-mannose metabolic process (GO:0019673)3.22240652
72thymic T cell selection (GO:0045061)3.21920016
73phosphatidylethanolamine biosynthetic process (GO:0006646)3.21831116
74regulation of early endosome to late endosome transport (GO:2000641)3.21655029
75barbed-end actin filament capping (GO:0051016)3.21362213
76androgen biosynthetic process (GO:0006702)3.20166927
77protein localization to endosome (GO:0036010)3.19801376
78adherens junction assembly (GO:0034333)3.18871326
79negative regulation of glycoprotein metabolic process (GO:1903019)3.18264600
80fibroblast migration (GO:0010761)3.17068885
81regulation of interleukin-13 production (GO:0032656)3.14690919
82response to muramyl dipeptide (GO:0032495)3.10766224
83regulation of mammary gland epithelial cell proliferation (GO:0033599)3.09845069
84T cell lineage commitment (GO:0002360)3.09839601
85nephron tubule formation (GO:0072079)3.09319539
86positive regulation of steroid hormone secretion (GO:2000833)3.07145973
87negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.05734885
88gland morphogenesis (GO:0022612)3.04259931
89lipoxygenase pathway (GO:0019372)3.03909702
90regulation of female gonad development (GO:2000194)3.03842020
91cellular extravasation (GO:0045123)3.03225261
92regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.02961978
93regulation of cellular respiration (GO:0043457)3.01824380
94protein heterotrimerization (GO:0070208)3.01641369
95dendritic cell chemotaxis (GO:0002407)3.00948083
96cell-substrate adherens junction assembly (GO:0007045)3.00275999
97focal adhesion assembly (GO:0048041)3.00275999
98microtubule bundle formation (GO:0001578)2.99514603
99positive regulation of interferon-alpha production (GO:0032727)2.99129166
100oligosaccharide catabolic process (GO:0009313)2.97490305
101nucleotide phosphorylation (GO:0046939)2.94787056
102negative thymic T cell selection (GO:0045060)2.94494807
103glomerular basement membrane development (GO:0032836)2.93809618
104ceramide catabolic process (GO:0046514)2.91779401
105auditory receptor cell differentiation (GO:0042491)2.91630316
106ruffle organization (GO:0031529)2.90599342
107regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90507877
108neuron cell-cell adhesion (GO:0007158)2.90416053
109positive regulation of DNA recombination (GO:0045911)2.90173838
110regulation of monocyte differentiation (GO:0045655)2.90095273
111regulation of type 2 immune response (GO:0002828)2.88263487
112negative regulation of granulocyte differentiation (GO:0030853)2.88097656
113apoptotic process involved in morphogenesis (GO:0060561)2.88056568
114neutrophil activation involved in immune response (GO:0002283)2.86370659
115positive regulation of smooth muscle cell migration (GO:0014911)2.84882550
116phosphatidylethanolamine metabolic process (GO:0046337)2.84610487
117proline biosynthetic process (GO:0006561)2.81525051
118chaperone mediated protein folding requiring cofactor (GO:0051085)2.81133597
119sphingolipid catabolic process (GO:0030149)2.81110303
120NIK/NF-kappaB signaling (GO:0038061)2.80661297
121positive regulation of gamma-delta T cell activation (GO:0046645)2.80296001
122mature B cell differentiation involved in immune response (GO:0002313)2.79599712
123positive regulation of CREB transcription factor activity (GO:0032793)2.77538767
124regulation of interferon-alpha production (GO:0032647)2.77344515
125type B pancreatic cell proliferation (GO:0044342)2.76644716
126regulation of chromatin binding (GO:0035561)2.76472314
127negative regulation of erythrocyte differentiation (GO:0045647)2.76202531
128modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.75152679
129positive regulation by organism of defense response of other organism involved in symbiotic interact2.75152679
130modulation by symbiont of host immune response (GO:0052553)2.75152679
131positive regulation by symbiont of host defense response (GO:0052509)2.75152679
132modulation by symbiont of host defense response (GO:0052031)2.75152679
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.75152679
134regulation of MHC class II biosynthetic process (GO:0045346)2.74287208
135positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.73891483
136hyaluronan catabolic process (GO:0030214)2.72700135
137detection of other organism (GO:0098543)2.72041907
138skin morphogenesis (GO:0043589)2.71995525
139regulation of apoptotic process involved in morphogenesis (GO:1902337)2.70351999
140positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.68647246
141activation of JUN kinase activity (GO:0007257)2.66734855
142cortical actin cytoskeleton organization (GO:0030866)2.66680409
143membrane lipid catabolic process (GO:0046466)2.66391059
144COPI coating of Golgi vesicle (GO:0048205)2.66257210
145Golgi transport vesicle coating (GO:0048200)2.66257210
146CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.65268187
147T-helper cell differentiation (GO:0042093)2.65268187
148urea cycle (GO:0000050)2.64949663
149B cell receptor signaling pathway (GO:0050853)2.64910745
150basement membrane organization (GO:0071711)2.64361432
151ribosomal small subunit biogenesis (GO:0042274)2.64239830
152positive regulation of macrophage cytokine production (GO:0060907)2.64092584
153regulation of phospholipid biosynthetic process (GO:0071071)2.63351104
154positive regulation of type 2 immune response (GO:0002830)2.62417767
155modulation by symbiont of host cellular process (GO:0044068)2.61993100
156bone trabecula formation (GO:0060346)2.61395316
157cranial nerve structural organization (GO:0021604)2.59097660
158adenine nucleotide transport (GO:0051503)2.58687217
159regulation of transforming growth factor beta1 production (GO:0032908)2.56551373
160positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.56309313
161heterochromatin organization (GO:0070828)2.55978213
162developmental pigmentation (GO:0048066)2.55165478
163neutrophil activation (GO:0042119)2.52907791
164G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.52805835
165positive regulation of interleukin-12 production (GO:0032735)2.52727053
166modulation by virus of host process (GO:0019054)2.52638836
167negative regulation of viral process (GO:0048525)2.51523263
168positive regulation of immunoglobulin mediated immune response (GO:0002891)2.50892435
169positive regulation of B cell mediated immunity (GO:0002714)2.50892435
170collagen metabolic process (GO:0032963)2.50463343
171positive regulation of endothelial cell apoptotic process (GO:2000353)2.49453314
172collagen catabolic process (GO:0030574)2.46993969
173imidazole-containing compound metabolic process (GO:0052803)2.46992332
174protein retention in ER lumen (GO:0006621)2.46848413
175endocytic recycling (GO:0032456)2.45534361
176collagen fibril organization (GO:0030199)2.43591915
177regulation of translational fidelity (GO:0006450)2.42163568
178regulation of NFAT protein import into nucleus (GO:0051532)2.40760076
179positive regulation of myotube differentiation (GO:0010831)2.39278395
180DNA strand renaturation (GO:0000733)2.39190772
181negative T cell selection (GO:0043383)2.38832062
182cell-substrate junction assembly (GO:0007044)2.38772048
183urea metabolic process (GO:0019627)2.38737048
184positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.37255692
185cellular response to virus (GO:0098586)2.37168704
186actin filament bundle assembly (GO:0051017)2.36736108
187actin filament bundle organization (GO:0061572)2.36736108
188multicellular organismal macromolecule metabolic process (GO:0044259)2.35479761
189negative regulation of fatty acid transport (GO:2000192)2.33466554
190Arp2/3 complex-mediated actin nucleation (GO:0034314)2.32176142
191regulation of glucose import in response to insulin stimulus (GO:2001273)2.30919331
192multicellular organismal catabolic process (GO:0044243)2.30374128
193very-low-density lipoprotein particle assembly (GO:0034379)2.29925935
194regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.29321595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.84575109
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.59069500
3VDR_21846776_ChIP-Seq_THP-1_Human3.58437336
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.50892260
5* MYC_22102868_ChIP-Seq_BL_Human3.31248570
6LXR_22292898_ChIP-Seq_THP-1_Human3.24413873
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.13372333
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.04941542
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.04729948
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.00097025
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.92488226
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.83884483
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.67073299
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59200461
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.52438571
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.52018685
17* ELK3_25401928_ChIP-Seq_HUVEC_Human2.50154729
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.48731087
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.47614311
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.42913464
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.41137402
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.34046995
23GBX2_23144817_ChIP-Seq_PC3_Human2.32022070
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20449922
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14494891
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09157402
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08560748
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01401084
29RACK7_27058665_Chip-Seq_MCF-7_Human1.99979879
30KDM2B_26808549_Chip-Seq_DND41_Human1.92939059
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91654604
32P68_20966046_ChIP-Seq_HELA_Human1.90495937
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89493423
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.89419187
35MAF_26560356_Chip-Seq_TH2_Human1.84148683
36GATA1_19941826_ChIP-Seq_K562_Human1.81683203
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.80328922
38CTCF_27219007_Chip-Seq_ERYTHROID_Human1.78316093
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77402940
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75520996
41TCF7_22412390_ChIP-Seq_EML_Mouse1.73545325
42MAF_26560356_Chip-Seq_TH1_Human1.72020431
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.68562147
44TP53_18474530_ChIP-ChIP_U2OS_Human1.67535688
45E2F7_22180533_ChIP-Seq_HELA_Human1.67396424
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64386926
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.63711767
48KDM2B_26808549_Chip-Seq_K562_Human1.63612928
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62172688
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61290853
51* SA1_27219007_Chip-Seq_ERYTHROID_Human1.60945653
52AHR_22903824_ChIP-Seq_MCF-7_Human1.60515817
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58237008
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.58209877
55TP53_22127205_ChIP-Seq_IMR90_Human1.58169602
56UTX_26944678_Chip-Seq_JUKART_Human1.57070574
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57017860
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56987939
59* SMC4_20622854_ChIP-Seq_HELA_Human1.56751277
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56151407
61* ELF1_20517297_ChIP-Seq_JURKAT_Human1.52202650
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51534551
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51029007
64SPI1_23127762_ChIP-Seq_K562_Human1.50827345
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50707868
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50319114
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49675590
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.49494520
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.49093425
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47891424
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43673368
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42342080
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.41800247
74MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.41339054
75SMAD4_21799915_ChIP-Seq_A2780_Human1.41275415
76AR_25329375_ChIP-Seq_VCAP_Human1.40718215
77BCL6_27268052_Chip-Seq_Bcells_Human1.39061526
78RUNX_20019798_ChIP-Seq_JUKART_Human1.38939675
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37671854
80RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37671854
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35125452
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34853827
83VDR_24787735_ChIP-Seq_THP-1_Human1.34853234
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.34658958
85RARA_24833708_ChIP-Seq_LIVER_Mouse1.33056091
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32092013
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31849874
88SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31480619
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31104779
90STAT1_17558387_ChIP-Seq_HELA_Human1.29890441
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29499890
92XRN2_22483619_ChIP-Seq_HELA_Human1.29349294
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29163581
94BCOR_27268052_Chip-Seq_Bcells_Human1.28822103
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28665438
96CTCF_27219007_Chip-Seq_Bcells_Human1.27879616
97P300_19829295_ChIP-Seq_ESCs_Human1.27209053
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27145866
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26654284
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26384349
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26214981
102NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26035222
103JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25543743
104NCOR1_26117541_ChIP-Seq_K562_Human1.25383595
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24683237
106CIITA_25753668_ChIP-Seq_RAJI_Human1.23837696
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.23420227
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22754489
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21777087
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21762256
111SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21404049
112* PHF8_20622854_ChIP-Seq_HELA_Human1.19676007
113TP63_17297297_ChIP-ChIP_HaCaT_Human1.18447599
114UBF1/2_26484160_Chip-Seq_HMECs_Human1.18259424
115RUNX1_22412390_ChIP-Seq_EML_Mouse1.17439137
116ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17423669
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17374067
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16451333
119CTCF_21964334_Chip-Seq_Bcells_Human1.16441568
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16316507
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15068136
122MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14992295
123SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14965857
124HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14767180
125PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13794297
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13741556
127ARNT_22903824_ChIP-Seq_MCF-7_Human1.13245178
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12478756
129GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12092607
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10579293
131SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10431518
132* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10102719
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10035138
134RARB_24833708_ChIP-Seq_LIVER_Mouse1.09406255
135GATA1_19941827_ChIP-Seq_MEL_Mouse1.08581529
136CREB1_26743006_Chip-Seq_LNCaP_Human1.08077221
137* SA1_27219007_Chip-Seq_Bcells_Human1.06937999
138TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06414674
139MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06029985
140ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05706148
141CTCF_26484167_Chip-Seq_Bcells_Mouse1.04695150
142RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04449637
143SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04402657
144CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04293041
145KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03249637
146PU_27001747_Chip-Seq_BMDM_Mouse1.02863267
147GATA2_19941826_ChIP-Seq_K562_Human1.02798699
148SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02580773
149RNF2_27304074_Chip-Seq_ESCs_Mouse1.02109643
150SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01445271
151STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01148937
152CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00810796
153PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00570835
154E2F1_20622854_ChIP-Seq_HELA_Human1.00507501
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00469775
156FOXM1_23109430_ChIP-Seq_U2OS_Human1.00346853
157SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99449354
158CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99305981
159CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99161531
160E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98996436
161BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97841135
162VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96221637
163SMAD3_21741376_ChIP-Seq_HESCs_Human0.94928691
164MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94557653
165LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92950980
166FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92775774
167KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92765698
168SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92522029
169CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91927370
170SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91478550
171TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88870107
172TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87711935
173POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87711935
174VDR_24763502_ChIP-Seq_THP-1_Human0.87414511
175AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86197173
176RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85728160
177EZH2_27304074_Chip-Seq_ESCs_Mouse0.85510854
178FLI1_27457419_Chip-Seq_LIVER_Mouse0.84473934
179ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83763885
180NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83172241
181NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83172241
182SCL_19346495_ChIP-Seq_HPC-7_Human0.83034113
183PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82567616
184PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81536878
185TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81464450
186NOTCH1_21737748_ChIP-Seq_TLL_Human0.81117598
187FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80890264
188SUZ12_27294783_Chip-Seq_ESCs_Mouse0.80692002
189TP63_23658742_ChIP-Seq_EP156T_Human0.80671430
190* EZH2_27294783_Chip-Seq_NPCs_Mouse0.78047702
191CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.77865027
192CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77646949

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.20615582
2MP0008438_abnormal_cutaneous_collagen4.84674826
3MP0003279_aneurysm4.75542182
4MP0001835_abnormal_antigen_presentation4.73962782
5MP0001958_emphysema4.47893249
6MP0000372_irregular_coat_pigmentation3.40972273
7MP0000569_abnormal_digit_pigmentation3.24028954
8MP0003879_abnormal_hair_cell3.16234454
9MP0006292_abnormal_olfactory_placode3.13963549
10MP0005075_abnormal_melanosome_morpholog3.04389647
11MP0003436_decreased_susceptibility_to2.97230595
12MP0003806_abnormal_nucleotide_metabolis2.87895185
13MP0005670_abnormal_white_adipose2.79536740
14MP0005000_abnormal_immune_tolerance2.77598405
15MP0009785_altered_susceptibility_to2.75364591
16MP0002132_abnormal_respiratory_system2.69100007
17MP0003172_abnormal_lysosome_physiology2.60511311
18MP0002877_abnormal_melanocyte_morpholog2.46598250
19MP0002876_abnormal_thyroid_physiology2.44261599
20MP0002419_abnormal_innate_immunity2.43554244
21MP0005025_abnormal_response_to2.42612494
22MP0002148_abnormal_hypersensitivity_rea2.39045915
23MP0003303_peritoneal_inflammation2.38618155
24MP0001485_abnormal_pinna_reflex2.28052349
25MP0003091_abnormal_cell_migration2.23013697
26MP0004381_abnormal_hair_follicle2.14686431
27MP0005503_abnormal_tendon_morphology2.13523101
28MP0003724_increased_susceptibility_to2.12962372
29MP0002405_respiratory_system_inflammati2.10626583
30MP0009840_abnormal_foam_cell2.09674623
31MP0001348_abnormal_lacrimal_gland2.08504435
32MP0000015_abnormal_ear_pigmentation2.05718855
33MP0005174_abnormal_tail_pigmentation2.05137480
34MP0003878_abnormal_ear_physiology1.98815251
35MP0005377_hearing/vestibular/ear_phenot1.98815251
36MP0000751_myopathy1.98189914
37MP0002452_abnormal_antigen_presenting1.91141739
38MP0005058_abnormal_lysosome_morphology1.86661930
39MP0001800_abnormal_humoral_immune1.85344114
40MP0005248_abnormal_Harderian_gland1.84647640
41MP0003763_abnormal_thymus_physiology1.77527204
42MP0005451_abnormal_body_composition1.77335427
43MP0002089_abnormal_postnatal_growth/wei1.76616538
44MP0001853_heart_inflammation1.73864989
45MP0001849_ear_inflammation1.72667180
46MP0005171_absent_coat_pigmentation1.68909044
47MP0005671_abnormal_response_to1.67950933
48MP0005409_darkened_coat_color1.67481786
49MP0003011_delayed_dark_adaptation1.66371932
50MP0001790_abnormal_immune_system1.65552388
51MP0005387_immune_system_phenotype1.65552388
52MP0005623_abnormal_meninges_morphology1.65258833
53MP0001533_abnormal_skeleton_physiology1.65183409
54MP0002723_abnormal_immune_serum1.63912190
55MP0003890_abnormal_embryonic-extraembry1.63387292
56MP0001819_abnormal_immune_cell1.59157864
57MP0005076_abnormal_cell_differentiation1.57484039
58MP0002420_abnormal_adaptive_immunity1.55418660
59MP0005275_abnormal_skin_tensile1.55376176
60MP0004510_myositis1.53592279
61MP0009384_cardiac_valve_regurgitation1.50683755
62MP0005464_abnormal_platelet_physiology1.50663798
63MP0000003_abnormal_adipose_tissue1.49409971
64MP0002998_abnormal_bone_remodeling1.47516261
65MP0008004_abnormal_stomach_pH1.46903899
66MP0004019_abnormal_vitamin_homeostasis1.43239697
67MP0002138_abnormal_hepatobiliary_system1.36292463
68MP0003315_abnormal_perineum_morphology1.33220592
69MP0003111_abnormal_nucleus_morphology1.32278570
70MP0001542_abnormal_bone_strength1.31571595
71MP0000733_abnormal_muscle_development1.27881271
72MP0000858_altered_metastatic_potential1.27736675
73MP0006082_CNS_inflammation1.26277183
74MP0001845_abnormal_inflammatory_respons1.26101256
75MP0001963_abnormal_hearing_physiology1.25892921
76MP0003136_yellow_coat_color1.25399220
77MP0004947_skin_inflammation1.20151847
78MP0004130_abnormal_muscle_cell1.18991695
79MP0002102_abnormal_ear_morphology1.18640442
80MP0000026_abnormal_inner_ear1.17334270
81MP0005390_skeleton_phenotype1.15325584
82MP0008260_abnormal_autophagy1.13239592
83MP0000747_muscle_weakness1.09625853
84MP0002060_abnormal_skin_morphology1.08004697
85MP0004185_abnormal_adipocyte_glucose1.05381301
86MP0008874_decreased_physiological_sensi1.01589229
87MP0003075_altered_response_to1.01286222
88MP0000681_abnormal_thyroid_gland0.99896626
89MP0002295_abnormal_pulmonary_circulatio0.99499628
90MP0004782_abnormal_surfactant_physiolog0.98902450
91MP0003183_abnormal_peptide_metabolism0.97636140
92MP0005508_abnormal_skeleton_morphology0.97283886
93MP0009763_increased_sensitivity_to0.96894094
94MP0009115_abnormal_fat_cell0.96760690
95MP0000013_abnormal_adipose_tissue0.96329424
96MP0002971_abnormal_brown_adipose0.94874371
97MP0000685_abnormal_immune_system0.94680468
98MP0001661_extended_life_span0.94269165
99MP0001346_abnormal_lacrimal_gland0.93979454
100MP0008469_abnormal_protein_level0.93674916
101MP0010155_abnormal_intestine_physiology0.92384422
102MP0000716_abnormal_immune_system0.92335260
103MP0005375_adipose_tissue_phenotype0.92230647
104MP0003453_abnormal_keratinocyte_physiol0.91241754
105MP0000678_abnormal_parathyroid_gland0.90946697
106MP0000920_abnormal_myelination0.90518242
107MP0005408_hypopigmentation0.89989287
108MP0005647_abnormal_sex_gland0.87240441
109MP0002249_abnormal_larynx_morphology0.85754835
110MP0003300_gastrointestinal_ulcer0.85640716
111MP0004233_abnormal_muscle_weight0.85317856
112MP0003718_maternal_effect0.85147273
113MP0000759_abnormal_skeletal_muscle0.83713193
114MP0005167_abnormal_blood-brain_barrier0.83672041
115MP0005257_abnormal_intraocular_pressure0.83413665
116MP0004858_abnormal_nervous_system0.81354768
117MP0005310_abnormal_salivary_gland0.80106932
118MP0005621_abnormal_cell_physiology0.79224637
119MP0010307_abnormal_tumor_latency0.79072270
120MP0005360_urolithiasis0.78892924
121MP0002396_abnormal_hematopoietic_system0.78775221
122MP0001730_embryonic_growth_arrest0.77520637
123MP0010329_abnormal_lipoprotein_level0.77418541
124MP0005023_abnormal_wound_healing0.77402306
125MP0003566_abnormal_cell_adhesion0.76938801
126MP0005187_abnormal_penis_morphology0.75892129
127MP0000750_abnormal_muscle_regeneration0.74682533
128MP0002398_abnormal_bone_marrow0.74186190
129MP0002970_abnormal_white_adipose0.73207194
130MP0002136_abnormal_kidney_physiology0.72551130
131MP0001614_abnormal_blood_vessel0.72283219
132MP0002722_abnormal_immune_system0.72135398
133MP0004808_abnormal_hematopoietic_stem0.71417734
134MP0005197_abnormal_uvea_morphology0.70861752
135MP0010386_abnormal_urinary_bladder0.69148795
136MP0003448_altered_tumor_morphology0.69026460
137MP0000343_altered_response_to0.68913250
138MP0002075_abnormal_coat/hair_pigmentati0.68686637
139MP0009053_abnormal_anal_canal0.68080613
140MP0005164_abnormal_response_to0.67043593
141MP0005666_abnormal_adipose_tissue0.66973319
142MP0002638_abnormal_pupillary_reflex0.66581719
143MP0000371_diluted_coat_color0.66581529
144MP0004087_abnormal_muscle_fiber0.65335856
145MP0000613_abnormal_salivary_gland0.64839989
146MP0003942_abnormal_urinary_system0.64374775
147MP0002019_abnormal_tumor_incidence0.64233154
148MP0004272_abnormal_basement_membrane0.62700953
149MP0000639_abnormal_adrenal_gland0.62656398
150MP0002254_reproductive_system_inflammat0.62517236
151MP0002429_abnormal_blood_cell0.62490994
152MP0000350_abnormal_cell_proliferation0.62124785
153MP0002693_abnormal_pancreas_physiology0.61715700
154MP0000767_abnormal_smooth_muscle0.60924164
155MP0009764_decreased_sensitivity_to0.60369653
156MP0005166_decreased_susceptibility_to0.60126268
157MP0002896_abnormal_bone_mineralization0.59482990
158MP0001986_abnormal_taste_sensitivity0.58398880
159MP0000689_abnormal_spleen_morphology0.56765738
160MP0008995_early_reproductive_senescence0.55676077

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)7.98647128
2Gastrointestinal infarctions (HP:0005244)7.96440331
3Action tremor (HP:0002345)7.56402560
4Myokymia (HP:0002411)7.13052118
5Abnormality of the prostate (HP:0008775)6.75035823
6Diplopia (HP:0000651)6.68409132
7Abnormality of binocular vision (HP:0011514)6.68409132
8Progressive cerebellar ataxia (HP:0002073)6.25105239
9Sensorimotor neuropathy (HP:0007141)5.47709449
10Osteomalacia (HP:0002749)4.97839239
11Vacuolated lymphocytes (HP:0001922)4.96888129
12Cheilitis (HP:0100825)4.86850253
13Chronic obstructive pulmonary disease (HP:0006510)4.65316872
14Obstructive lung disease (HP:0006536)4.65316872
15Mediastinal lymphadenopathy (HP:0100721)4.65276524
16Ureteral stenosis (HP:0000071)4.41834511
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.39042743
18Protrusio acetabuli (HP:0003179)4.29670081
19Ulnar bowing (HP:0003031)4.28918732
20Premature rupture of membranes (HP:0001788)4.25621304
21Ureteral obstruction (HP:0006000)4.24375590
22Amaurosis fugax (HP:0100576)4.18492927
23Arterial thrombosis (HP:0004420)4.13584568
24Joint swelling (HP:0001386)3.87025479
25Aortic dissection (HP:0002647)3.77844626
26Abnormality of male internal genitalia (HP:0000022)3.54923833
27Pulmonary fibrosis (HP:0002206)3.52343979
28Thin bony cortex (HP:0002753)3.45677132
29Joint hemorrhage (HP:0005261)3.40530306
30Pulmonary infiltrates (HP:0002113)3.38377395
31Eczematoid dermatitis (HP:0000976)3.35938896
32Hyperacusis (HP:0010780)3.26740739
33Hypophosphatemic rickets (HP:0004912)3.26561562
34Chest pain (HP:0100749)3.26248329
35Prostate neoplasm (HP:0100787)3.25414247
36Acrocyanosis (HP:0001063)3.24622447
37Delusions (HP:0000746)3.21598564
38Papillary thyroid carcinoma (HP:0002895)3.20163454
39Systemic lupus erythematosus (HP:0002725)3.19014380
40Protuberant abdomen (HP:0001538)3.16327754
41Meningitis (HP:0001287)3.13457890
42Dysdiadochokinesis (HP:0002075)3.11484187
43Bladder diverticulum (HP:0000015)3.08575571
44Hemoptysis (HP:0002105)3.04122931
45Spinal cord lesions (HP:0100561)2.98504527
46Syringomyelia (HP:0003396)2.98504527
47Recurrent gram-negative bacterial infections (HP:0005420)2.97898597
48Ankle contracture (HP:0006466)2.96526022
49Spinal cord compression (HP:0002176)2.94628446
50Gangrene (HP:0100758)2.91963889
51Annular pancreas (HP:0001734)2.89790706
52Emphysema (HP:0002097)2.88906828
53Recurrent bacterial skin infections (HP:0005406)2.79617426
54Vertebral compression fractures (HP:0002953)2.78260253
55Epistaxis (HP:0000421)2.75436539
56Disproportionate tall stature (HP:0001519)2.70658011
57Hemorrhage of the eye (HP:0011885)2.68744798
58Flat cornea (HP:0007720)2.67772873
59Pulmonary embolism (HP:0002204)2.67375821
60Esophageal varix (HP:0002040)2.66974994
61Recurrent abscess formation (HP:0002722)2.65688356
62Testicular atrophy (HP:0000029)2.64768946
63Genu recurvatum (HP:0002816)2.58661963
64Vasculitis (HP:0002633)2.57869096
65Skin rash (HP:0000988)2.56652080
66Anorexia (HP:0002039)2.56114426
67Hypercholesterolemia (HP:0003124)2.54124475
68Thin ribs (HP:0000883)2.54036374
69Turricephaly (HP:0000262)2.52501711
70Abnormality of calcium-phosphate metabolism (HP:0100530)2.52371228
71Aortic aneurysm (HP:0004942)2.52109320
72Cervical subluxation (HP:0003308)2.51458132
73Absent frontal sinuses (HP:0002688)2.49579177
74Premature graying of hair (HP:0002216)2.41908740
75Squamous cell carcinoma (HP:0002860)2.41094868
76Elevated erythrocyte sedimentation rate (HP:0003565)2.40819966
77Poikiloderma (HP:0001029)2.39881173
78Gastrointestinal stroma tumor (HP:0100723)2.39124445
79Colitis (HP:0002583)2.38898934
80Joint stiffness (HP:0001387)2.37625694
81Reduced antithrombin III activity (HP:0001976)2.31691701
82Camptodactyly of toe (HP:0001836)2.30620899
83Thrombophlebitis (HP:0004418)2.29391666
84Vascular tortuosity (HP:0004948)2.28906093
85Biconcave vertebral bodies (HP:0004586)2.28881457
86Recurrent cutaneous fungal infections (HP:0011370)2.27551115
87Chronic mucocutaneous candidiasis (HP:0002728)2.27551115
88Soft skin (HP:0000977)2.27328293
89Tachypnea (HP:0002789)2.27286646
90Cerebral aneurysm (HP:0004944)2.26213958
91Submucous cleft hard palate (HP:0000176)2.26173007
92Abnormality of the pleura (HP:0002103)2.25731285
93Abnormality of the pericardium (HP:0001697)2.25546038
94Menorrhagia (HP:0000132)2.25468387
95Type 1 muscle fiber predominance (HP:0003803)2.24687280
96Glomerulopathy (HP:0100820)2.23756511
97Stomatitis (HP:0010280)2.22383791
98Renal duplication (HP:0000075)2.20275321
99Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.19753483
100Bowed forearm bones (HP:0003956)2.18340103
101Bowing of the arm (HP:0006488)2.18340103
102Delayed epiphyseal ossification (HP:0002663)2.17929848
103Persistence of primary teeth (HP:0006335)2.17124612
104Wormian bones (HP:0002645)2.16982625
105Polygenic inheritance (HP:0010982)2.16438494
106Type I transferrin isoform profile (HP:0003642)2.15064896
107Distal lower limb amyotrophy (HP:0008944)2.14807224
108Craniofacial hyperostosis (HP:0004493)2.14444139
109Recurrent skin infections (HP:0001581)2.13718124
110Abnormality of the thoracic spine (HP:0100711)2.13223526
111Dilatation of the ascending aorta (HP:0005111)2.12056236
112Multiple lipomas (HP:0001012)2.11995202
113Gingival bleeding (HP:0000225)2.11436847
114Generalized amyotrophy (HP:0003700)2.11402234
115Coronal craniosynostosis (HP:0004440)2.10968218
116Abnormality of Sharpey fibers (HP:0100685)2.10109956
117Insomnia (HP:0100785)2.09328028
118Arthralgia (HP:0002829)2.08488230
119Intestinal fistula (HP:0100819)2.08011413
120Blue sclerae (HP:0000592)2.07224499
121Shallow orbits (HP:0000586)2.05185539
122Femoral bowing (HP:0002980)2.04814023
123Bowel diverticulosis (HP:0005222)2.03398461
124Increased variability in muscle fiber diameter (HP:0003557)2.03127983
125Spinal canal stenosis (HP:0003416)2.03013253
126Elbow flexion contracture (HP:0002987)2.02182973
127Thoracic kyphosis (HP:0002942)2.01848147
128Thyroid carcinoma (HP:0002890)2.01805340
129Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.01451515
130Agammaglobulinemia (HP:0004432)2.01209891
131Spinal rigidity (HP:0003306)2.00946727
132Recurrent fungal infections (HP:0002841)2.00692437
133Abnormality of macrophages (HP:0004311)1.99899522
134Arterial tortuosity (HP:0005116)1.99115821
135Hypoplasia of the fovea (HP:0007750)1.98671695
136Aplasia/Hypoplasia of the fovea (HP:0008060)1.98671695
137Joint contractures involving the joints of the feet (HP:0100492)1.98557013
138Flexion contracture of toe (HP:0005830)1.98557013
139Vaginal fistula (HP:0004320)1.97811249
140Dislocated radial head (HP:0003083)1.95629249
141Renovascular hypertension (HP:0100817)1.94946632
142Prolonged partial thromboplastin time (HP:0003645)1.94582600
143Achilles tendon contracture (HP:0001771)1.94183858
144Metaphyseal dysplasia (HP:0100255)1.93860687
145Mildly elevated creatine phosphokinase (HP:0008180)1.92556961
146Metaphyseal irregularity (HP:0003025)1.91507995
147Dysostosis multiplex (HP:0000943)1.91068284
148Congenital sensorineural hearing impairment (HP:0008527)1.90919510
149Urinary glycosaminoglycan excretion (HP:0003541)1.90373092
150Mucopolysacchariduria (HP:0008155)1.90373092
151Spondylolisthesis (HP:0003302)1.89850654
152Rectovaginal fistula (HP:0000143)1.89133218
153Rectal fistula (HP:0100590)1.89133218
154Abnormality of skeletal muscle fiber size (HP:0012084)1.89007484
155Mitral valve prolapse (HP:0001634)1.88395699
156Restrictive lung disease (HP:0002091)1.86603378
157Cellulitis (HP:0100658)1.86172067
158Vertigo (HP:0002321)1.86044932
159Abnormality of the radial head (HP:0003995)1.85094852
160Abdominal distention (HP:0003270)1.84706525
161Fragile skin (HP:0001030)1.83440040
162Spontaneous hematomas (HP:0007420)1.83397647
163Abnormality of the common coagulation pathway (HP:0010990)1.82515553
164Increased connective tissue (HP:0009025)1.81813368
165Gastrointestinal inflammation (HP:0004386)1.81666104
166Abnormality of the distal phalanx of the thumb (HP:0009617)1.81535156
167Increased IgM level (HP:0003496)1.81262088
168Asymmetry of the thorax (HP:0001555)1.79510359
169Abnormality of the Achilles tendon (HP:0005109)1.79254190
170Overriding aorta (HP:0002623)1.78107730
171Depression (HP:0000716)1.77691984
172Distal lower limb muscle weakness (HP:0009053)1.77552726
173Lower limb amyotrophy (HP:0007210)1.77489328
174Abnormality of the lumbar spine (HP:0100712)1.77194523
175Abnormality of polysaccharide metabolism (HP:0011012)1.76740500
176Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76740500
177Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76740500
178Upper limb amyotrophy (HP:0009129)1.76013983
179Distal upper limb amyotrophy (HP:0007149)1.76013983
180Mitral regurgitation (HP:0001653)1.74360806
181Short middle phalanx of the 5th finger (HP:0004220)1.73606237
182Dysmetric saccades (HP:0000641)1.72916552
183Hyperammonemia (HP:0001987)1.72587135
184Panhypogammaglobulinemia (HP:0003139)1.70246258
185Facial edema (HP:0000282)1.69405247
186Tibial bowing (HP:0002982)1.69266069
187Hyperkalemia (HP:0002153)1.66795264
188Abnormal delayed hypersensitivity skin test (HP:0002963)1.65306862
189Rickets (HP:0002748)1.65287528
190Albinism (HP:0001022)1.65087545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK26.85619386
2TAOK16.55400156
3MAP3K35.29259131
4MAP2K34.85653495
5MAP3K114.84652302
6EEF2K3.62575184
7NLK3.45895288
8SMG13.11590001
9MAP3K102.86422364
10TTN2.68015805
11CDK122.38405523
12RIPK42.37729337
13ICK2.32172979
14NEK92.26963835
15MAP3K142.25204917
16TRIB32.24054032
17TNIK2.15093163
18SIK12.14612585
19TEC2.04944859
20PIK3CG1.76035196
21MAP3K11.68477290
22MAP2K71.61982627
23PDGFRA1.49881523
24MAP3K51.49746922
25FES1.46374529
26ARAF1.44039179
27CDK41.43704609
28RPS6KA21.37065027
29TESK21.33952994
30MOS1.32025216
31ITK1.27702091
32BTK1.26026341
33LIMK11.23622982
34MAPK151.22125591
35TBK11.20581873
36PKN21.19445446
37TAOK31.18471695
38NME21.17678806
39CASK1.15793029
40PDPK11.15532124
41MTOR1.13034383
42RPS6KC11.09878393
43RPS6KL11.09878393
44EIF2AK31.09773831
45CDC42BPA1.08635345
46YES11.06339756
47IKBKB1.03717094
48SIK20.98024765
49KSR20.96862120
50PAK20.95871949
51TIE10.95494876
52TRPM70.94794734
53IRAK30.93366763
54MST1R0.92191629
55RPS6KA60.91371695
56MAPK110.89865853
57PRKD20.87981053
58DAPK30.86211788
59CAMK1G0.84127140
60BMPR20.84115121
61MAP3K90.81672953
62PIK3CA0.80581294
63TGFBR20.80423601
64MELK0.80243433
65IRAK20.77458059
66DYRK1B0.75716355
67PTK20.74770031
68TESK10.74732357
69JAK30.69263854
70ERBB30.69214585
71PRPF4B0.69070129
72DDR20.69035185
73CDK80.68642528
74BRAF0.67010368
75HCK0.66768353
76TXK0.66544675
77MAP3K80.65227335
78ERBB40.64151081
79JAK10.63530286
80PIM20.63297224
81ILK0.63179331
82WNK10.61797847
83CDK70.61715506
84CSK0.60838158
85PAK10.60291907
86PRKCD0.59807723
87EIF2AK20.59451726
88JAK20.57627923
89CAMK1D0.57553723
90MAPK70.57303963
91MYLK0.56278453
92SYK0.55946094
93PDK10.55472160
94GRK10.55312579
95PAK40.54664284
96PRKG10.53621075
97ZAK0.53606334
98MARK20.52961663
99MUSK0.51871248
100TYK20.50192391
101GRK60.48616497
102HIPK20.48407510
103MKNK20.48406158
104MAP4K10.47756757
105AURKA0.47034176
106MARK30.46975411
107TLK10.46203832
108IKBKE0.45449277
109LYN0.43549862
110KDR0.43428883
111ZAP700.43044520
112BMX0.41683073
113RPS6KA10.41144748
114CHUK0.40953481
115FGFR40.40860699
116MATK0.40324415
117AKT20.39706812
118CDK11A0.39526326
119IRAK40.39061251
120CAMKK10.38925789
121CHEK10.37459341
122CDK150.37439732
123RAF10.37059664
124RIPK10.36987338
125MST40.36486351
126MAPK120.36479758
127CHEK20.36226369
128EPHB10.35884237
129ROCK10.35712904
130MAPKAPK20.34909130
131MAP2K10.34154199
132MAP3K60.33745395
133CSF1R0.32438565
134BLK0.31292474
135CLK10.30803632
136KIT0.30374577
137CDK60.30253657
138NTRK30.27086437
139SGK20.26343066
140FLT30.24377318
141PDGFRB0.23465624
142PIM10.23103558
143EPHA30.22949608
144MAP3K130.22784432
145SGK30.22156525
146DAPK20.20114339
147PTK60.18942435
148ERN10.18762623
149MAP3K120.17991024
150PASK0.17929143
151MET0.17658801
152AKT30.17655336
153STK100.16579621
154PRKCQ0.16322939
155LCK0.15778779
156TGFBR10.15292323
157ALK0.14705618
158MAPK40.14595791
159GRK70.13939593
160PBK0.13385548
161FGR0.12479243
162MKNK10.12205026
163INSRR0.12019228
164PRKG20.11728222
165IGF1R0.11517003

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041222.91471546
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.65208425
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.63435057
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.56620005
5Jak-STAT signaling pathway_Homo sapiens_hsa046302.42812159
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.40255141
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.35603720
8Leishmaniasis_Homo sapiens_hsa051402.33971394
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.24002028
10Staphylococcus aureus infection_Homo sapiens_hsa051502.16623096
11Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.07516259
12Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.94941936
13Graft-versus-host disease_Homo sapiens_hsa053321.93970826
14Type I diabetes mellitus_Homo sapiens_hsa049401.90859423
15Osteoclast differentiation_Homo sapiens_hsa043801.86289585
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82462536
17Sphingolipid metabolism_Homo sapiens_hsa006001.81233918
18Measles_Homo sapiens_hsa051621.77320078
19Viral myocarditis_Homo sapiens_hsa054161.70756888
20Fructose and mannose metabolism_Homo sapiens_hsa000511.69005930
21TNF signaling pathway_Homo sapiens_hsa046681.67410621
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.64310319
23Bladder cancer_Homo sapiens_hsa052191.63687138
24Hepatitis C_Homo sapiens_hsa051601.57777276
25Rheumatoid arthritis_Homo sapiens_hsa053231.53933974
26Toxoplasmosis_Homo sapiens_hsa051451.50449354
27Complement and coagulation cascades_Homo sapiens_hsa046101.49119360
28Galactose metabolism_Homo sapiens_hsa000521.48953081
29Tuberculosis_Homo sapiens_hsa051521.46818168
30Allograft rejection_Homo sapiens_hsa053301.45420969
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45398296
32Influenza A_Homo sapiens_hsa051641.42422796
33Pentose phosphate pathway_Homo sapiens_hsa000301.40350563
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39889935
35Legionellosis_Homo sapiens_hsa051341.37449851
36Notch signaling pathway_Homo sapiens_hsa043301.36647407
37Acute myeloid leukemia_Homo sapiens_hsa052211.31539519
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.30722631
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.30169386
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29051348
41Systemic lupus erythematosus_Homo sapiens_hsa053221.28608949
42Sphingolipid signaling pathway_Homo sapiens_hsa040711.27933774
43Phagosome_Homo sapiens_hsa041451.26912337
44Non-small cell lung cancer_Homo sapiens_hsa052231.25590093
45Propanoate metabolism_Homo sapiens_hsa006401.25227892
46Malaria_Homo sapiens_hsa051441.21230135
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.21187257
48Steroid biosynthesis_Homo sapiens_hsa001001.17262770
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16125286
50Chemokine signaling pathway_Homo sapiens_hsa040621.14870496
51Caffeine metabolism_Homo sapiens_hsa002321.14780625
52HTLV-I infection_Homo sapiens_hsa051661.13529585
53Primary immunodeficiency_Homo sapiens_hsa053401.13178622
54Endometrial cancer_Homo sapiens_hsa052131.12956997
55Focal adhesion_Homo sapiens_hsa045101.12213015
56Thyroid cancer_Homo sapiens_hsa052161.11870720
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10606193
58Prion diseases_Homo sapiens_hsa050201.09308374
59NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09171512
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.08565590
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08360995
62Antigen processing and presentation_Homo sapiens_hsa046121.04350652
63Pertussis_Homo sapiens_hsa051331.03739436
64Biosynthesis of amino acids_Homo sapiens_hsa012301.03293734
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02194783
66Lysine degradation_Homo sapiens_hsa003101.01830793
67Histidine metabolism_Homo sapiens_hsa003400.99849954
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98713815
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96969660
70Hematopoietic cell lineage_Homo sapiens_hsa046400.95029587
71Hedgehog signaling pathway_Homo sapiens_hsa043400.92368334
72B cell receptor signaling pathway_Homo sapiens_hsa046620.91819557
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91234804
74Autoimmune thyroid disease_Homo sapiens_hsa053200.90992069
75Apoptosis_Homo sapiens_hsa042100.90738970
76Prolactin signaling pathway_Homo sapiens_hsa049170.89364806
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.87827183
78T cell receptor signaling pathway_Homo sapiens_hsa046600.86829857
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.83350750
80Asthma_Homo sapiens_hsa053100.83274210
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82105946
82Ovarian steroidogenesis_Homo sapiens_hsa049130.81438007
83Viral carcinogenesis_Homo sapiens_hsa052030.79420114
84ECM-receptor interaction_Homo sapiens_hsa045120.79394681
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78194343
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77860122
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77409334
88Salmonella infection_Homo sapiens_hsa051320.76856792
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75936671
90Amoebiasis_Homo sapiens_hsa051460.75707765
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75665699
92Small cell lung cancer_Homo sapiens_hsa052220.74817772
93Type II diabetes mellitus_Homo sapiens_hsa049300.74025217
94Lysosome_Homo sapiens_hsa041420.72601054
95Inositol phosphate metabolism_Homo sapiens_hsa005620.72433392
96African trypanosomiasis_Homo sapiens_hsa051430.71711731
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71595081
98Basal cell carcinoma_Homo sapiens_hsa052170.70672447
99Hepatitis B_Homo sapiens_hsa051610.70334128
100Chronic myeloid leukemia_Homo sapiens_hsa052200.70030745
101MicroRNAs in cancer_Homo sapiens_hsa052060.68817221
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68773291
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67594980
104mTOR signaling pathway_Homo sapiens_hsa041500.64948572
105Insulin resistance_Homo sapiens_hsa049310.64050185
106N-Glycan biosynthesis_Homo sapiens_hsa005100.63568399
107PPAR signaling pathway_Homo sapiens_hsa033200.61831209
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.60461795
109Epstein-Barr virus infection_Homo sapiens_hsa051690.60149461
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59141498
111Platelet activation_Homo sapiens_hsa046110.58458855
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57660760
113Collecting duct acid secretion_Homo sapiens_hsa049660.56841072
114Melanoma_Homo sapiens_hsa052180.54649621
115Arginine biosynthesis_Homo sapiens_hsa002200.53337899
116VEGF signaling pathway_Homo sapiens_hsa043700.53295401
117Glioma_Homo sapiens_hsa052140.52591157
118Colorectal cancer_Homo sapiens_hsa052100.51823814
119Insulin signaling pathway_Homo sapiens_hsa049100.51717643
120Renal cell carcinoma_Homo sapiens_hsa052110.51582975
121Renin-angiotensin system_Homo sapiens_hsa046140.50614531
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49855143
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49699819
124Pancreatic cancer_Homo sapiens_hsa052120.49602664
125Base excision repair_Homo sapiens_hsa034100.49415848
126Tight junction_Homo sapiens_hsa045300.49336300
127Retinol metabolism_Homo sapiens_hsa008300.49087528
128Shigellosis_Homo sapiens_hsa051310.48571055
129Endocytosis_Homo sapiens_hsa041440.48303394
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48136568
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47536027
132Melanogenesis_Homo sapiens_hsa049160.47477127
133DNA replication_Homo sapiens_hsa030300.47193568
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46798418
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46232857
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46070759
137Carbon metabolism_Homo sapiens_hsa012000.45697276
138Prostate cancer_Homo sapiens_hsa052150.45260626
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44909299
140Phenylalanine metabolism_Homo sapiens_hsa003600.43723725
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42357611
142Other glycan degradation_Homo sapiens_hsa005110.39867261
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38207258
144Fatty acid elongation_Homo sapiens_hsa000620.36120497
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35616094
146Vitamin B6 metabolism_Homo sapiens_hsa007500.34176392
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33813811
148HIF-1 signaling pathway_Homo sapiens_hsa040660.33770823
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32548312
150Herpes simplex infection_Homo sapiens_hsa051680.32252368
151Proteoglycans in cancer_Homo sapiens_hsa052050.31875920
152beta-Alanine metabolism_Homo sapiens_hsa004100.30034729

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