ESPNP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microtubule depolymerization (GO:0007019)6.50116837
2sperm motility (GO:0030317)6.19307994
3phosphatidylethanolamine biosynthetic process (GO:0006646)6.12951122
4monoubiquitinated protein deubiquitination (GO:0035520)5.99546224
5protein polyglutamylation (GO:0018095)5.77086307
6chromosome condensation (GO:0030261)5.73626312
7phosphatidylethanolamine metabolic process (GO:0046337)5.55960201
8acrosome reaction (GO:0007340)5.44782024
9fusion of sperm to egg plasma membrane (GO:0007342)5.30498884
10DNA packaging (GO:0006323)5.24690614
11microtubule polymerization or depolymerization (GO:0031109)4.98814168
12regulation of chromatin binding (GO:0035561)4.97714663
13protein K48-linked deubiquitination (GO:0071108)4.82293302
14microtubule severing (GO:0051013)4.43560698
15sperm capacitation (GO:0048240)4.40399141
16sperm-egg recognition (GO:0035036)4.19611018
17binding of sperm to zona pellucida (GO:0007339)4.12367047
18plasma membrane fusion (GO:0045026)3.99582989
19spermatid development (GO:0007286)3.89679106
20musculoskeletal movement (GO:0050881)3.82904319
21multicellular organismal movement (GO:0050879)3.82904319
22chromatin silencing (GO:0006342)3.73334295
23nucleosome disassembly (GO:0006337)3.72908689
24protein-DNA complex disassembly (GO:0032986)3.72908689
25water-soluble vitamin biosynthetic process (GO:0042364)3.68788497
26calcium ion-dependent exocytosis (GO:0017156)3.55701323
27lung epithelium development (GO:0060428)3.48885394
28reflex (GO:0060004)3.45492902
29rRNA methylation (GO:0031167)3.31239198
30rRNA modification (GO:0000154)3.28583094
31cell-cell recognition (GO:0009988)3.27530664
32multicellular organism reproduction (GO:0032504)3.25694372
33response to misfolded protein (GO:0051788)3.24750965
34misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.20094805
35reproduction (GO:0000003)3.16619842
36spermatogenesis (GO:0007283)3.14967700
37male gamete generation (GO:0048232)3.13905085
38motile cilium assembly (GO:0044458)3.08615221
39cranial nerve morphogenesis (GO:0021602)3.08191243
40regulation of cilium movement (GO:0003352)3.03998905
41nephron tubule morphogenesis (GO:0072078)3.00617517
42nephron epithelium morphogenesis (GO:0072088)3.00617517
43RNA localization (GO:0006403)2.90734649
44axoneme assembly (GO:0035082)2.90435597
45gamete generation (GO:0007276)2.89889482
46regulation of histone H3-K27 methylation (GO:0061085)2.88721936
47spermatid nucleus differentiation (GO:0007289)2.86861975
48endothelial cell chemotaxis (GO:0035767)2.86470902
49phosphatidylcholine biosynthetic process (GO:0006656)2.85488874
50RNA destabilization (GO:0050779)2.81738384
51negative regulation of gene expression, epigenetic (GO:0045814)2.80754341
52peptidyl-lysine dimethylation (GO:0018027)2.79665470
53positive regulation of endothelial cell differentiation (GO:0045603)2.77556953
54cellular ketone body metabolic process (GO:0046950)2.77358965
55mitotic G1 DNA damage checkpoint (GO:0031571)2.76585087
56heterochromatin organization (GO:0070828)2.74652544
57indolalkylamine metabolic process (GO:0006586)2.72733804
58regulation of centriole replication (GO:0046599)2.71835723
59cilium movement (GO:0003341)2.71817638
60epithelial cilium movement (GO:0003351)2.71727893
61peptidyl-threonine dephosphorylation (GO:0035970)2.71419715
62peptidyl-glutamic acid modification (GO:0018200)2.70490139
63single strand break repair (GO:0000012)2.70189795
64respiratory tube development (GO:0030323)2.69207145
65exogenous drug catabolic process (GO:0042738)2.68295430
66nonmotile primary cilium assembly (GO:0035058)2.67658947
67oxygen transport (GO:0015671)2.67331873
68gas transport (GO:0015669)2.66768191
69sexual reproduction (GO:0019953)2.64455022
70drug catabolic process (GO:0042737)2.64417648
71nucleoside transmembrane transport (GO:1901642)2.63855524
72proline metabolic process (GO:0006560)2.61900579
73positive regulation of synapse maturation (GO:0090129)2.61018645
74cilium or flagellum-dependent cell motility (GO:0001539)2.60314812
75intracellular estrogen receptor signaling pathway (GO:0030520)2.59206434
76membrane depolarization during action potential (GO:0086010)2.58901131
77axonemal dynein complex assembly (GO:0070286)2.57981991
78cellular anion homeostasis (GO:0030002)2.57585798
79regulation of female gonad development (GO:2000194)2.57363060
80positive regulation of guanylate cyclase activity (GO:0031284)2.56249075
81limb development (GO:0060173)2.54889361
82appendage development (GO:0048736)2.54889361
83G1 DNA damage checkpoint (GO:0044783)2.54641803
84face development (GO:0060324)2.53245934
85negative regulation of DNA-templated transcription, elongation (GO:0032785)2.52859806
86ganglion development (GO:0061548)2.52632822
87basic amino acid transport (GO:0015802)2.52583637
88single fertilization (GO:0007338)2.52184148
89centriole assembly (GO:0098534)2.52006648
90centriole replication (GO:0007099)2.51666732
91gamma-aminobutyric acid transport (GO:0015812)2.49631955
92gene silencing (GO:0016458)2.49275884
93cellular biogenic amine catabolic process (GO:0042402)2.49058405
94amine catabolic process (GO:0009310)2.49058405
95protein localization to synapse (GO:0035418)2.47957847
96presynaptic membrane assembly (GO:0097105)2.46497026
97sex determination (GO:0007530)2.45969313
98negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.45057909
99histone H3-K9 demethylation (GO:0033169)2.44724514
100positive regulation of gene expression, epigenetic (GO:0045815)2.44351847

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.31836837
2EZH2_22144423_ChIP-Seq_EOC_Human3.21839834
3LXR_22292898_ChIP-Seq_THP-1_Human2.82657132
4P68_20966046_ChIP-Seq_HELA_Human2.75166796
5CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.68509450
6DROSHA_22980978_ChIP-Seq_HELA_Human2.66557857
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49563657
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.44979001
9* CTCF_27219007_Chip-Seq_Bcells_Human2.41216235
10BCL6_27268052_Chip-Seq_Bcells_Human2.37418550
11ELF1_20517297_ChIP-Seq_JURKAT_Human2.35496797
12* SMC4_20622854_ChIP-Seq_HELA_Human2.31729276
13E2F1_20622854_ChIP-Seq_HELA_Human2.24802806
14PHF8_20622854_ChIP-Seq_HELA_Human2.13551745
15CTCF_20526341_ChIP-Seq_ESCs_Human2.06160463
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.02556892
17FOXM1_23109430_ChIP-Seq_U2OS_Human1.95649735
18BCOR_27268052_Chip-Seq_Bcells_Human1.93984723
19SA1_27219007_Chip-Seq_ERYTHROID_Human1.82641981
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80225194
21E2F7_22180533_ChIP-Seq_HELA_Human1.79549912
22SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.77167348
23VDR_22108803_ChIP-Seq_LS180_Human1.71865906
24TP63_22573176_ChIP-Seq_HFKS_Human1.71780107
25RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.70791451
26* RACK7_27058665_Chip-Seq_MCF-7_Human1.66093942
27CREB1_26743006_Chip-Seq_LNCaP_Human1.65531805
28EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.64971427
29YY1_22570637_ChIP-Seq_MALME-3M_Human1.63487563
30EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.59352547
31ERA_21632823_ChIP-Seq_H3396_Human1.58388711
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57726680
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.57593609
34CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54675463
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.52031732
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51837466
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.49977910
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49572033
39MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.47635560
40P300_27268052_Chip-Seq_Bcells_Human1.46317404
41* RUNX1_27514584_Chip-Seq_MCF-7_Human1.46158218
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44885107
43DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42076711
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41441889
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41441889
46TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.40999903
47RAC3_21632823_ChIP-Seq_H3396_Human1.40459098
48SA1_27219007_Chip-Seq_Bcells_Human1.39890062
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38394422
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.37213888
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34693963
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32669791
53* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32209926
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31769034
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30746191
56OCT4_19829295_ChIP-Seq_ESCs_Human1.30664132
57CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28524100
58P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.26677883
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26168625
60CTCF_21964334_Chip-Seq_Bcells_Human1.25910961
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25856834
62E2F1_17053090_ChIP-ChIP_MCF-7_Human1.25331463
63* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23236753
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21774868
65MYC_22102868_ChIP-Seq_BL_Human1.20993974
66OCT4_20526341_ChIP-Seq_ESCs_Human1.20504750
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.20092967
68FOXP1_21924763_ChIP-Seq_HESCs_Human1.19826829
69EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.19775768
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18754811
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17179863
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14029207
73* KDM2B_26808549_Chip-Seq_DND41_Human1.13670627
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12649772
75TAF2_19829295_ChIP-Seq_ESCs_Human1.12476697
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12165158
77KLF5_25053715_ChIP-Seq_YYC3_Human1.11604004
78MYC_19829295_ChIP-Seq_ESCs_Human1.10317350
79* KDM2B_26808549_Chip-Seq_K562_Human1.09971603
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08348634
81NANOG_20526341_ChIP-Seq_ESCs_Human1.08082279
82SOX2_22085726_ChIP-Seq_NPCs_Mouse1.07552876
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07147881
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.06905785
85RARA_24833708_ChIP-Seq_LIVER_Mouse1.06848490
86P53_21459846_ChIP-Seq_SAOS-2_Human1.06739699
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06520718
88* KDM2B_26808549_Chip-Seq_JURKAT_Human1.06325281
89SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05112088
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04919563
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04848074
92P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01554726
93GATA1_19941826_ChIP-Seq_K562_Human1.01127632
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00518576
95CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99740536
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99167623
97IRF1_19129219_ChIP-ChIP_H3396_Human0.99041511
98CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99004764
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98754332
100TP53_22127205_ChIP-Seq_IMR90_Human0.97672809

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.82455152
2MP0003878_abnormal_ear_physiology5.82455152
3MP0005410_abnormal_fertilization4.13291805
4MP0003880_abnormal_central_pattern3.43904550
5MP0004742_abnormal_vestibular_system3.42608254
6MP0003879_abnormal_hair_cell3.21889265
7MP0003646_muscle_fatigue3.03126608
8MP0005670_abnormal_white_adipose2.86994751
9MP0002249_abnormal_larynx_morphology2.55237926
10MP0005645_abnormal_hypothalamus_physiol2.43347471
11MP0004147_increased_porphyrin_level2.35152203
12MP0000569_abnormal_digit_pigmentation2.20812248
13MP0002822_catalepsy2.19972781
14MP0008789_abnormal_olfactory_epithelium2.07369312
15MP0003698_abnormal_male_reproductive1.92579955
16MP0008995_early_reproductive_senescence1.89508873
17MP0001486_abnormal_startle_reflex1.88492578
18MP0003123_paternal_imprinting1.79819884
19MP0006276_abnormal_autonomic_nervous1.64335046
20MP0005451_abnormal_body_composition1.63520979
21MP0005360_urolithiasis1.62944847
22MP0000678_abnormal_parathyroid_gland1.61713501
23MP0005499_abnormal_olfactory_system1.58647075
24MP0005394_taste/olfaction_phenotype1.58647075
25MP0005083_abnormal_biliary_tract1.57199652
26MP0000026_abnormal_inner_ear1.50900929
27MP0004133_heterotaxia1.48374788
28MP0001929_abnormal_gametogenesis1.45508516
29MP0002557_abnormal_social/conspecific_i1.40583111
30MP0002735_abnormal_chemical_nociception1.39645384
31MP0006292_abnormal_olfactory_placode1.39042707
32MP0004043_abnormal_pH_regulation1.37929165
33MP0001188_hyperpigmentation1.36907693
34MP0001963_abnormal_hearing_physiology1.34633000
35MP0004264_abnormal_extraembryonic_tissu1.32560473
36MP0001348_abnormal_lacrimal_gland1.23249016
37MP0005167_abnormal_blood-brain_barrier1.19931957
38MP0008875_abnormal_xenobiotic_pharmacok1.19172457
39MP0003718_maternal_effect1.19143757
40MP0004233_abnormal_muscle_weight1.17242494
41MP0002161_abnormal_fertility/fecundity1.16345143
42MP0005423_abnormal_somatic_nervous1.13258032
43MP0002736_abnormal_nociception_after1.13004642
44MP0001968_abnormal_touch/_nociception1.11982097
45MP0004885_abnormal_endolymph1.09092476
46MP0001529_abnormal_vocalization1.08575883
47MP0006072_abnormal_retinal_apoptosis1.08004764
48MP0002067_abnormal_sensory_capabilities1.07492340
49MP0003122_maternal_imprinting1.06701281
50MP0000681_abnormal_thyroid_gland1.06659905
51MP0003195_calcinosis1.05491296
52MP0001485_abnormal_pinna_reflex1.04927127
53MP0002210_abnormal_sex_determination1.03361528
54MP0010329_abnormal_lipoprotein_level1.02635093
55MP0003656_abnormal_erythrocyte_physiolo1.02584384
56MP0002089_abnormal_postnatal_growth/wei1.01529753
57MP0001666_abnormal_nutrient_absorption0.99426753
58MP0009697_abnormal_copulation0.98553333
59MP0005551_abnormal_eye_electrophysiolog0.98444325
60MP0008961_abnormal_basal_metabolism0.98008031
61MP0002229_neurodegeneration0.98001671
62MP0002733_abnormal_thermal_nociception0.94096023
63MP0005332_abnormal_amino_acid0.90512127
64MP0001905_abnormal_dopamine_level0.90407841
65MP0002653_abnormal_ependyma_morphology0.89670109
66MP0009278_abnormal_bone_marrow0.89448202
67MP0001765_abnormal_ion_homeostasis0.88736949
68MP0001501_abnormal_sleep_pattern0.88442931
69MP0003942_abnormal_urinary_system0.85912254
70MP0001970_abnormal_pain_threshold0.85091311
71MP0009115_abnormal_fat_cell0.81339866
72MP0002928_abnormal_bile_duct0.80037123
73MP0004145_abnormal_muscle_electrophysio0.79564086
74MP0005386_behavior/neurological_phenoty0.79091047
75MP0004924_abnormal_behavior0.79091047
76MP0001440_abnormal_grooming_behavior0.78397584
77MP0003632_abnormal_nervous_system0.78033546
78MP0010094_abnormal_chromosome_stability0.76610260
79MP0001145_abnormal_male_reproductive0.75110119
80MP0002734_abnormal_mechanical_nocicepti0.74621139
81MP0000653_abnormal_sex_gland0.72328486
82MP0003115_abnormal_respiratory_system0.72261336
83MP0000538_abnormal_urinary_bladder0.70849444
84MP0002932_abnormal_joint_morphology0.69819138
85MP0003631_nervous_system_phenotype0.67782635
86MP0003786_premature_aging0.67335426
87MP0008872_abnormal_physiological_respon0.67190189
88MP0002752_abnormal_somatic_nervous0.65997570
89MP0001502_abnormal_circadian_rhythm0.64898239
90MP0000003_abnormal_adipose_tissue0.63841261
91MP0002272_abnormal_nervous_system0.61900632
92MP0002876_abnormal_thyroid_physiology0.60623860
93MP0000534_abnormal_ureter_morphology0.60502821
94MP0003638_abnormal_response/metabolism_0.60274824
95MP0003119_abnormal_digestive_system0.60156372
96MP0003111_abnormal_nucleus_morphology0.59303422
97MP0004858_abnormal_nervous_system0.56907331
98MP0005666_abnormal_adipose_tissue0.55090482
99MP0005375_adipose_tissue_phenotype0.54312266
100MP0002572_abnormal_emotion/affect_behav0.54304203

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.02527193
2Cutaneous melanoma (HP:0012056)4.35425006
3Hyperglycinemia (HP:0002154)3.86375955
4Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.74663052
5Severe visual impairment (HP:0001141)3.72882880
6Methylmalonic acidemia (HP:0002912)3.68420691
7Hypoplastic ischia (HP:0003175)3.57553799
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.34290175
9Progressive cerebellar ataxia (HP:0002073)3.27436250
10Methylmalonic aciduria (HP:0012120)3.26656006
11Abnormality of the parathyroid morphology (HP:0011766)3.22237328
12Abnormality of the pubic bones (HP:0003172)3.21616309
13Bell-shaped thorax (HP:0001591)3.16840018
14Congenital sensorineural hearing impairment (HP:0008527)3.14516947
15Visual hallucinations (HP:0002367)3.02722387
16Reticulocytosis (HP:0001923)2.96450138
17Abnormality of the ischium (HP:0003174)2.95205954
18Abnormality of binocular vision (HP:0011514)2.88339725
19Diplopia (HP:0000651)2.88339725
20Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.86615438
21Absent epiphyses (HP:0010577)2.86615438
22Hyperkalemia (HP:0002153)2.85993296
23Homocystinuria (HP:0002156)2.82522851
24Abnormality of homocysteine metabolism (HP:0010919)2.82522851
25Abnormality of the aortic arch (HP:0012303)2.70299381
26Chronic bronchitis (HP:0004469)2.67814713
27Abnormal respiratory motile cilium physiology (HP:0012261)2.63853699
28Bony spicule pigmentary retinopathy (HP:0007737)2.61367845
29Abnormality of the fingertips (HP:0001211)2.59120975
30Confusion (HP:0001289)2.53466523
31Tubulointerstitial nephritis (HP:0001970)2.52131310
32Abnormality of the vitamin B12 metabolism (HP:0004341)2.51107159
33Postural instability (HP:0002172)2.49870460
34Metaphyseal cupping (HP:0003021)2.49801722
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46204392
36Duplicated collecting system (HP:0000081)2.45342149
37Renovascular hypertension (HP:0100817)2.43592309
38Impulsivity (HP:0100710)2.40110035
39Poikilocytosis (HP:0004447)2.38069560
40Urethral obstruction (HP:0000796)2.35682906
41Congenital stationary night blindness (HP:0007642)2.32038872
42Abnormality of the renal collecting system (HP:0004742)2.26576048
43Chromsome breakage (HP:0040012)2.25134719
44Neoplasm of the heart (HP:0100544)2.23803916
45Abnormality of dental color (HP:0011073)2.23030206
46Chronic hepatic failure (HP:0100626)2.22106426
47Gaze-evoked nystagmus (HP:0000640)2.19257217
48Neurodegeneration (HP:0002180)2.18111605
49Abnormality of vitamin B metabolism (HP:0004340)2.15987001
50Bilateral microphthalmos (HP:0007633)2.14603385
51Abnormality of pyrimidine metabolism (HP:0004353)2.09371804
52Abdominal distention (HP:0003270)2.08547804
53Bicornuate uterus (HP:0000813)2.08167138
54Hypoplasia of the thymus (HP:0000778)2.08128448
55Delayed epiphyseal ossification (HP:0002663)2.06216081
56Abnormality of reticulocytes (HP:0004312)2.06124199
57Obsessive-compulsive behavior (HP:0000722)2.05841619
58Lip pit (HP:0100267)2.05604184
59Flattened epiphyses (HP:0003071)2.03859708
60Abnormality of glycine metabolism (HP:0010895)2.03205592
61Abnormality of serine family amino acid metabolism (HP:0010894)2.03205592
62Lymphangioma (HP:0100764)2.03071731
63Potter facies (HP:0002009)2.00100214
64Facial shape deformation (HP:0011334)2.00100214
65Abnormality of the heme biosynthetic pathway (HP:0010472)1.97911873
66Prolonged partial thromboplastin time (HP:0003645)1.97261750
67Abnormal ciliary motility (HP:0012262)1.96261208
68Deep venous thrombosis (HP:0002625)1.92608282
69Aplasia/Hypoplasia of the earlobes (HP:0009906)1.89714060
70Nephronophthisis (HP:0000090)1.89155048
71Rhinitis (HP:0012384)1.87609304
72Abnormality of monocarboxylic acid metabolism (HP:0010996)1.87596406
73Cystic liver disease (HP:0006706)1.84807163
74Flat acetabular roof (HP:0003180)1.83628828
75Hypothermia (HP:0002045)1.82808842
76Protuberant abdomen (HP:0001538)1.79359049
77Meningioma (HP:0002858)1.78629905
78Amelogenesis imperfecta (HP:0000705)1.78426770
79Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78153848
80Dynein arm defect of respiratory motile cilia (HP:0012255)1.77329510
81Absent/shortened dynein arms (HP:0200106)1.77329510
82Respiratory distress (HP:0002098)1.76820196
83Cholecystitis (HP:0001082)1.76789263
84Abnormal gallbladder physiology (HP:0012438)1.76789263
85Hypoalphalipoproteinemia (HP:0003233)1.75906238
86Stage 5 chronic kidney disease (HP:0003774)1.75251986
87Spastic paraparesis (HP:0002313)1.75246823
88Abnormal respiratory epithelium morphology (HP:0012253)1.74240942
89Abnormal respiratory motile cilium morphology (HP:0005938)1.74240942
90Abnormality of lateral ventricle (HP:0030047)1.73738985
91Abnormality of the femoral head (HP:0003368)1.72605133
92Broad distal phalanx of finger (HP:0009836)1.72356659
93Subcapsular cataract (HP:0000523)1.72232487
94Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.71939465
95Amblyopia (HP:0000646)1.71022781
96Abnormality of the epiphysis of the femoral head (HP:0010574)1.70825120
97Dicarboxylic aciduria (HP:0003215)1.70465032
98Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70465032
99Impaired smooth pursuit (HP:0007772)1.70387156
100Attenuation of retinal blood vessels (HP:0007843)1.69055844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.27540395
2PLK44.20343193
3LATS13.24272388
4MST1R3.12758593
5TAOK12.89717706
6SIK22.88691074
7CDK122.69827520
8FRK2.64326342
9TRIB32.62077652
10STK162.41936009
11NEK62.39827114
12MAP4K22.21074750
13NME11.99679906
14EPHA21.94844542
15DDR21.74278020
16ICK1.73211830
17NEK21.71089714
18MAP3K101.69051246
19CAMK1G1.52342211
20DYRK31.50476531
21CAMK1D1.47721397
22WNK41.46775489
23SMG11.42458999
24CDK71.42198132
25EEF2K1.35597476
26FGFR21.35094212
27BRD41.34656604
28CDC71.17864770
29TNK21.16524305
30TLK11.15562100
31TESK11.11494801
32MAPK151.08139614
33GRK11.05647877
34AKT31.01423945
35MAP3K71.00215787
36PKN20.99867530
37TAOK30.99142829
38ERN10.98912927
39STK380.95973973
40WNK10.95313427
41EIF2AK10.95204273
42MTOR0.94301020
43SIK10.94023104
44STK38L0.88841776
45MET0.88033349
46MUSK0.85644833
47CDK40.83041070
48CAMK40.83029071
49PASK0.82083895
50CAMKK10.79046618
51DYRK1B0.79010686
52MATK0.75394579
53PRKD30.75225217
54NUAK10.74656164
55CDK20.73282930
56MAP2K20.68121867
57MAPKAPK30.64626935
58RPS6KL10.63151145
59RPS6KC10.63151145
60PNCK0.62858045
61PRKAA10.62149997
62RPS6KA60.61468710
63CDK10.61381300
64ERBB20.56687475
65GSK3B0.56094930
66UHMK10.54937333
67NTRK20.51662210
68CHUK0.51072144
69ATR0.50599606
70CAMK10.50496998
71PDPK10.49796383
72BMX0.48589101
73RPS6KB20.47228124
74ZAK0.46145740
75MAPK80.46087438
76MAPK70.46034028
77MAPK130.45037675
78CHEK10.44171718
79TESK20.43931632
80IRAK20.43208650
81FGFR40.42665133
82MAPK140.41956145
83SGK10.40944965
84KIT0.40292257
85PLK10.39151277
86PRPF4B0.38931815
87TIE10.38494728
88ITK0.37793997
89NTRK30.37764293
90RPS6KA20.36073372
91PRKAA20.35948327
92MAPK110.34819619
93RPS6KA40.33573309
94AKT10.32968678
95TYRO30.32847741
96PTK2B0.32225952
97CHEK20.30600051
98CSNK1A10.30300560
99PRKG20.30277226
100GRK60.28695990

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.80495461
2Nicotine addiction_Homo sapiens_hsa050333.04277320
3ABC transporters_Homo sapiens_hsa020102.57169895
4Phenylalanine metabolism_Homo sapiens_hsa003602.35045527
5Arginine biosynthesis_Homo sapiens_hsa002202.21475610
6Lysine degradation_Homo sapiens_hsa003102.21282753
7Base excision repair_Homo sapiens_hsa034102.21269514
8Glycerophospholipid metabolism_Homo sapiens_hsa005642.17404808
9Linoleic acid metabolism_Homo sapiens_hsa005912.15446501
10Caffeine metabolism_Homo sapiens_hsa002322.06522597
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87975013
12Fat digestion and absorption_Homo sapiens_hsa049751.76155482
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73661458
14Histidine metabolism_Homo sapiens_hsa003401.73453269
15Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.71316487
16Arginine and proline metabolism_Homo sapiens_hsa003301.70685899
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68326159
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.67706436
19Taste transduction_Homo sapiens_hsa047421.61698777
20Tryptophan metabolism_Homo sapiens_hsa003801.56747332
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.52198926
22DNA replication_Homo sapiens_hsa030301.47606983
23Fatty acid degradation_Homo sapiens_hsa000711.47130723
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40076899
25Retinol metabolism_Homo sapiens_hsa008301.39549622
26Type II diabetes mellitus_Homo sapiens_hsa049301.38858469
27Vitamin digestion and absorption_Homo sapiens_hsa049771.36880515
28Biosynthesis of amino acids_Homo sapiens_hsa012301.36486843
29Nitrogen metabolism_Homo sapiens_hsa009101.34149190
30Chemical carcinogenesis_Homo sapiens_hsa052041.30055614
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26815709
32Bile secretion_Homo sapiens_hsa049761.22581167
33Ether lipid metabolism_Homo sapiens_hsa005651.21057180
34Basal cell carcinoma_Homo sapiens_hsa052171.19777807
35Fanconi anemia pathway_Homo sapiens_hsa034601.19680254
36Butanoate metabolism_Homo sapiens_hsa006501.19329694
37Fatty acid metabolism_Homo sapiens_hsa012121.18775857
38Olfactory transduction_Homo sapiens_hsa047401.17072046
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16708374
40Phototransduction_Homo sapiens_hsa047441.13268701
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.05029338
42Tyrosine metabolism_Homo sapiens_hsa003501.01992498
43Fructose and mannose metabolism_Homo sapiens_hsa000510.98322873
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94753571
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93850341
46Glutamatergic synapse_Homo sapiens_hsa047240.93438872
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92664385
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.92538397
49Synaptic vesicle cycle_Homo sapiens_hsa047210.84762190
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.83573231
51RNA transport_Homo sapiens_hsa030130.82880062
52Glycerolipid metabolism_Homo sapiens_hsa005610.81976795
53Hedgehog signaling pathway_Homo sapiens_hsa043400.79965080
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79759066
55Circadian entrainment_Homo sapiens_hsa047130.79662689
56Serotonergic synapse_Homo sapiens_hsa047260.79249888
57PPAR signaling pathway_Homo sapiens_hsa033200.77344715
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77009422
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.76661969
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.74990971
61Pyrimidine metabolism_Homo sapiens_hsa002400.73979116
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.68720618
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63619651
64N-Glycan biosynthesis_Homo sapiens_hsa005100.62859966
65Notch signaling pathway_Homo sapiens_hsa043300.61573029
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60489341
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59958898
68Spliceosome_Homo sapiens_hsa030400.59900188
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59112529
70Renin-angiotensin system_Homo sapiens_hsa046140.59085482
71Purine metabolism_Homo sapiens_hsa002300.58887174
72Complement and coagulation cascades_Homo sapiens_hsa046100.58444685
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56670782
74Sulfur relay system_Homo sapiens_hsa041220.54872410
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54574641
76mRNA surveillance pathway_Homo sapiens_hsa030150.54549986
77Nucleotide excision repair_Homo sapiens_hsa034200.53455277
78Cell cycle_Homo sapiens_hsa041100.51669514
79Carbon metabolism_Homo sapiens_hsa012000.51625563
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50549528
81Arachidonic acid metabolism_Homo sapiens_hsa005900.48888524
82Insulin resistance_Homo sapiens_hsa049310.48246074
83Metabolic pathways_Homo sapiens_hsa011000.47367517
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47265455
85Calcium signaling pathway_Homo sapiens_hsa040200.46492941
86Insulin secretion_Homo sapiens_hsa049110.46329926
87Peroxisome_Homo sapiens_hsa041460.45777468
88Mismatch repair_Homo sapiens_hsa034300.44915467
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44353077
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43435250
91Cocaine addiction_Homo sapiens_hsa050300.42585377
92Cholinergic synapse_Homo sapiens_hsa047250.42467810
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42121880
94beta-Alanine metabolism_Homo sapiens_hsa004100.40418343
95RNA polymerase_Homo sapiens_hsa030200.40046123
96Insulin signaling pathway_Homo sapiens_hsa049100.38477020
97Estrogen signaling pathway_Homo sapiens_hsa049150.34602723
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34600749
99Protein digestion and absorption_Homo sapiens_hsa049740.34398501
100Other glycan degradation_Homo sapiens_hsa005110.33904171

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