ESR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.23259651
2regulation of female gonad development (GO:2000194)6.13330449
3intestinal epithelial cell development (GO:0060576)6.02861055
4estrogen biosynthetic process (GO:0006703)4.90438757
5female gonad development (GO:0008585)4.67530129
6female gamete generation (GO:0007292)4.57504848
7DNA methylation involved in gamete generation (GO:0043046)4.52568374
8negative regulation of meiosis (GO:0045835)4.52328496
9regulation of RIG-I signaling pathway (GO:0039535)4.46772987
10protein K6-linked ubiquitination (GO:0085020)4.46026013
11regulation of meiosis (GO:0040020)4.45995780
12meiotic chromosome segregation (GO:0045132)4.40621688
13maturation of 5.8S rRNA (GO:0000460)4.39036683
14meiotic cell cycle (GO:0051321)4.35852819
15regulation of centriole replication (GO:0046599)4.20630433
16mitotic metaphase plate congression (GO:0007080)4.13866427
17regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.13204805
18aggressive behavior (GO:0002118)4.10014801
19prostate gland growth (GO:0060736)3.84269093
20multicellular organism reproduction (GO:0032504)3.77725030
21prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.76704311
22centriole assembly (GO:0098534)3.76633374
23response to pheromone (GO:0019236)3.70378277
24regulation of meiotic cell cycle (GO:0051445)3.66863987
25DNA damage induced protein phosphorylation (GO:0006975)3.65751527
26male meiosis (GO:0007140)3.61688520
27metaphase plate congression (GO:0051310)3.60134460
28myoblast migration (GO:0051451)3.57619824
29base-excision repair, AP site formation (GO:0006285)3.50104862
30protein K11-linked deubiquitination (GO:0035871)3.48838375
31attachment of spindle microtubules to kinetochore (GO:0008608)3.47636196
32facial nerve structural organization (GO:0021612)3.47395847
33* vagina development (GO:0060068)3.46644653
34regulation of meiosis I (GO:0060631)3.43820904
35establishment of protein localization to Golgi (GO:0072600)3.43632361
36indolalkylamine metabolic process (GO:0006586)3.38651832
37establishment of chromosome localization (GO:0051303)3.38402762
38negative regulation of keratinocyte proliferation (GO:0010839)3.37054655
39cellular ketone body metabolic process (GO:0046950)3.34450611
40positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.34327239
41mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.34327239
42negative regulation of smooth muscle cell differentiation (GO:0051151)3.34207367
43notochord development (GO:0030903)3.31671372
44chaperone-mediated protein transport (GO:0072321)3.30836910
45negative regulation of meiotic cell cycle (GO:0051447)3.28353748
46L-fucose metabolic process (GO:0042354)3.27601619
47L-fucose catabolic process (GO:0042355)3.27601619
48fucose catabolic process (GO:0019317)3.27601619
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.25596895
50regulation of mitotic spindle checkpoint (GO:1903504)3.25596895
51androgen biosynthetic process (GO:0006702)3.25238306
52positive regulation of DNA-dependent DNA replication (GO:2000105)3.24430474
53oocyte development (GO:0048599)3.24235330
54preassembly of GPI anchor in ER membrane (GO:0016254)3.23584550
55axoneme assembly (GO:0035082)3.18763400
56oocyte maturation (GO:0001556)3.16335674
57CENP-A containing nucleosome assembly (GO:0034080)3.11914057
58righting reflex (GO:0060013)3.11284276
59response to food (GO:0032094)3.11131344
60detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.10818961
61regulation of activation of Janus kinase activity (GO:0010533)3.09851578
62* female genitalia development (GO:0030540)3.09773004
63ketone body metabolic process (GO:1902224)3.09373856
64DNA deamination (GO:0045006)3.08583396
65regulation of mononuclear cell migration (GO:0071675)3.08156565
66DNA damage response, signal transduction resulting in transcription (GO:0042772)3.08139036
67ear development (GO:0043583)3.07806605
68male meiosis I (GO:0007141)3.06823754
69parturition (GO:0007567)3.06043062
70histone H3-K9 methylation (GO:0051567)3.06014718
71negative regulation of homotypic cell-cell adhesion (GO:0034111)3.05684525
72negative regulation of organelle assembly (GO:1902116)3.04306344
73protein polyglutamylation (GO:0018095)3.04269899
74neural tube formation (GO:0001841)3.03115437
75mismatch repair (GO:0006298)3.02731256
76kinetochore assembly (GO:0051382)3.02665603
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02354181
78indole-containing compound catabolic process (GO:0042436)3.01064661
79indolalkylamine catabolic process (GO:0046218)3.01064661
80tryptophan catabolic process (GO:0006569)3.01064661
81positive regulation of T cell apoptotic process (GO:0070234)2.99012662
82chromatin remodeling at centromere (GO:0031055)2.98358976
83cilium or flagellum-dependent cell motility (GO:0001539)2.97857970
84regulation of histone H3-K27 methylation (GO:0061085)2.95738554
85behavioral response to nicotine (GO:0035095)2.95684967
86centriole replication (GO:0007099)2.95253925
87lung secretory cell differentiation (GO:0061140)2.93947216
88superoxide anion generation (GO:0042554)2.93813347
89regulation of double-strand break repair via homologous recombination (GO:0010569)2.93561628
90DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.92823816
91protein targeting to Golgi (GO:0000042)2.92494655
92replicative senescence (GO:0090399)2.92357988
93DNA double-strand break processing (GO:0000729)2.91639797
94phosphatidylethanolamine metabolic process (GO:0046337)2.89709715
95regulation of centrosome duplication (GO:0010824)2.89257447
96mitotic chromosome condensation (GO:0007076)2.88769366
97regulation of exit from mitosis (GO:0007096)2.88751370
98negative regulation of axon extension involved in axon guidance (GO:0048843)2.87126574
99glycerophospholipid catabolic process (GO:0046475)2.86128439
100negative regulation of reproductive process (GO:2000242)2.85852677
101phosphatidylethanolamine biosynthetic process (GO:0006646)2.85189515
102type B pancreatic cell development (GO:0003323)2.83381355
103detection of light stimulus involved in sensory perception (GO:0050962)2.83373992
104detection of light stimulus involved in visual perception (GO:0050908)2.83373992
105positive regulation of mitochondrial membrane permeability (GO:0035794)2.82525446
106tryptophan metabolic process (GO:0006568)2.80925653
107positive regulation of interleukin-1 beta secretion (GO:0050718)2.80448611
108pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.79472511
109transepithelial transport (GO:0070633)2.78840456
110retrograde transport, vesicle recycling within Golgi (GO:0000301)2.78375452
111maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.77740923
112epithelial cilium movement (GO:0003351)2.77349227
113synapsis (GO:0007129)2.77324620
114negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.76766780
115negative regulation of DNA-templated transcription, elongation (GO:0032785)2.76766780
116cellular response to gamma radiation (GO:0071480)2.76116689
117phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.75992890
118regulation of establishment of cell polarity (GO:2000114)2.75973520
119photoreceptor cell maintenance (GO:0045494)2.75895277
120double-strand break repair via homologous recombination (GO:0000724)2.75265339
121androgen metabolic process (GO:0008209)2.74457169
122cranial nerve structural organization (GO:0021604)2.73980997
123protein localization to Golgi apparatus (GO:0034067)2.73630122
124positive regulation of developmental pigmentation (GO:0048087)2.72961099
125recombinational repair (GO:0000725)2.72396923
126sperm motility (GO:0030317)2.71848357
127kinetochore organization (GO:0051383)2.71551467
128DNA methylation (GO:0006306)2.70728338
129DNA alkylation (GO:0006305)2.70728338
130replication fork processing (GO:0031297)2.69883951
131kynurenine metabolic process (GO:0070189)2.69628349
132protein K48-linked deubiquitination (GO:0071108)2.68894218
133regulation of nuclear cell cycle DNA replication (GO:0033262)2.67150250
134negative regulation of transcription regulatory region DNA binding (GO:2000678)2.65753560
135regulation of acrosome reaction (GO:0060046)2.63584063
136positive regulation of defense response to virus by host (GO:0002230)2.63530417
137DNA replication-independent nucleosome assembly (GO:0006336)2.63519522
138DNA replication-independent nucleosome organization (GO:0034724)2.63519522
139negative regulation of cell division (GO:0051782)2.63131340
140reciprocal DNA recombination (GO:0035825)2.63116874
141reciprocal meiotic recombination (GO:0007131)2.63116874
142valine metabolic process (GO:0006573)2.62847080
143negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.62492188
144regulation of hippo signaling (GO:0035330)2.60813730
145chromosome segregation (GO:0007059)2.60653249
146mitotic sister chromatid segregation (GO:0000070)2.60072735
147spindle checkpoint (GO:0031577)2.59549700
148regulation of action potential (GO:0098900)2.59011469
149pyrimidine nucleotide catabolic process (GO:0006244)2.57763744
150negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.57714714
151estrogen metabolic process (GO:0008210)2.57472435
152positive regulation of hair follicle development (GO:0051798)2.57466228
153positive regulation of hair cycle (GO:0042635)2.57466228
154tachykinin receptor signaling pathway (GO:0007217)2.56562527
155nitric oxide biosynthetic process (GO:0006809)2.56357924
156negative regulation of nuclear division (GO:0051784)2.56077187
157positive regulation of humoral immune response (GO:0002922)2.55933490
158nucleotide transmembrane transport (GO:1901679)2.55548522
159purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.54381768
1603-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.54381768
161microtubule anchoring (GO:0034453)2.53635036
162negative regulation of execution phase of apoptosis (GO:1900118)2.53613541
163inner cell mass cell proliferation (GO:0001833)2.53605255
164positive regulation of interleukin-1 secretion (GO:0050716)2.53576151
165negative regulation of mast cell activation (GO:0033004)2.53199696
166positive regulation of interleukin-1 beta production (GO:0032731)2.52433517
167gene silencing by RNA (GO:0031047)2.52270302
168DNA demethylation (GO:0080111)2.51713904
169mannosylation (GO:0097502)2.51576695
170histone exchange (GO:0043486)2.51418919
171regulation of cilium movement (GO:0003352)2.50298724
172DNA methylation or demethylation (GO:0044728)2.49540837
173regulation of establishment or maintenance of cell polarity (GO:0032878)2.49441727
174DNA modification (GO:0006304)2.48248279
175oogenesis (GO:0048477)2.48237631
176cell wall macromolecule catabolic process (GO:0016998)2.47913386
177reproduction (GO:0000003)2.47784350
178spermatid development (GO:0007286)2.47440909
179RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46877402
180DNA synthesis involved in DNA repair (GO:0000731)2.46550644
181N-terminal protein amino acid acetylation (GO:0006474)2.46195379
182cornea development in camera-type eye (GO:0061303)2.45968446
183DNA integration (GO:0015074)2.45616936
184positive regulation of meiosis (GO:0045836)2.45496134
185T cell lineage commitment (GO:0002360)2.45398169
186negative regulation of axon guidance (GO:1902668)2.45284740
187regulation of interleukin-1 beta secretion (GO:0050706)2.45143761

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.56988550
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.54013739
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.41795935
4PCGF2_27294783_Chip-Seq_ESCs_Mouse3.25725731
5FLI1_27457419_Chip-Seq_LIVER_Mouse3.24467287
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.15433905
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.04530530
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78203227
9* KAP1_22055183_ChIP-Seq_ESCs_Mouse2.69722014
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.62524145
11SUZ12_27294783_Chip-Seq_NPCs_Mouse2.60730512
12GBX2_23144817_ChIP-Seq_PC3_Human2.50295468
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.47044463
14NFE2_27457419_Chip-Seq_LIVER_Mouse2.46733348
15E2F7_22180533_ChIP-Seq_HELA_Human2.45254844
16* ESR1_20079471_ChIP-ChIP_T-47D_Human2.39713730
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.27008466
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22414394
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20773902
20* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15415699
21EZH2_27294783_Chip-Seq_NPCs_Mouse2.08918676
22PCGF2_27294783_Chip-Seq_NPCs_Mouse2.07408566
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05149047
24NANOG_18555785_Chip-Seq_ESCs_Mouse2.03181658
25EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.01885471
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.96691641
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.96664190
28STAT3_18555785_Chip-Seq_ESCs_Mouse1.96390158
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.94774777
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89204821
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83113426
32SUZ12_18555785_Chip-Seq_ESCs_Mouse1.82700558
33AHR_22903824_ChIP-Seq_MCF-7_Human1.81977369
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.81586933
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81548896
36NMYC_18555785_Chip-Seq_ESCs_Mouse1.80296949
37P53_22387025_ChIP-Seq_ESCs_Mouse1.80088668
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75411022
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75399558
40E2F1_18555785_Chip-Seq_ESCs_Mouse1.74927768
41EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.74572977
42EZH2_22144423_ChIP-Seq_EOC_Human1.74479795
43RNF2_27304074_Chip-Seq_NSC_Mouse1.74026599
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72264389
45IGF1R_20145208_ChIP-Seq_DFB_Human1.71118034
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71045263
47SOX2_18555785_Chip-Seq_ESCs_Mouse1.70712325
48TP53_22573176_ChIP-Seq_HFKS_Human1.68572917
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67563743
50CMYC_18555785_Chip-Seq_ESCs_Mouse1.67477317
51CBP_20019798_ChIP-Seq_JUKART_Human1.67385153
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67385153
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65336490
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.64845191
55OCT4_18555785_Chip-Seq_ESCs_Mouse1.63864437
56ZFX_18555785_Chip-Seq_ESCs_Mouse1.63314669
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57288140
58KLF4_18555785_Chip-Seq_ESCs_Mouse1.56620282
59RUNX1_27457419_Chip-Seq_LIVER_Mouse1.55296754
60FUS_26573619_Chip-Seq_HEK293_Human1.54612317
61* BCAT_22108803_ChIP-Seq_LS180_Human1.54331999
62LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54065741
63* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53593991
64P300_18555785_Chip-Seq_ESCs_Mouse1.53189665
65ESRRB_18555785_Chip-Seq_ESCs_Mouse1.52096378
66CTCF_18555785_Chip-Seq_ESCs_Mouse1.51425998
67CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.48378998
68* TCF4_23295773_ChIP-Seq_U87_Human1.48208406
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48181798
70PU1_27457419_Chip-Seq_LIVER_Mouse1.47355695
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46251378
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45652356
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44013342
74EWS_26573619_Chip-Seq_HEK293_Human1.43687680
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.42122800
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41446060
77PKCTHETA_26484144_Chip-Seq_BREAST_Human1.40247058
78AR_25329375_ChIP-Seq_VCAP_Human1.36301341
79SMAD1_18555785_Chip-Seq_ESCs_Mouse1.35186431
80STAT1_17558387_ChIP-Seq_HELA_Human1.34596937
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33304820
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.32478638
83TCF4_22108803_ChIP-Seq_LS180_Human1.32040306
84HOXB7_26014856_ChIP-Seq_BT474_Human1.31700024
85* TAL1_26923725_Chip-Seq_HPCs_Mouse1.31443180
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29868707
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29289534
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.28311089
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27641152
90* GATA3_21878914_ChIP-Seq_MCF-7_Human1.27338430
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26885631
92IRF8_22096565_ChIP-ChIP_GC-B_Human1.25741314
93* STAT3_23295773_ChIP-Seq_U87_Human1.25500601
94* FLI1_21867929_ChIP-Seq_TH2_Mouse1.25428731
95* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25367432
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24424770
97* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24282117
98E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24180904
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23931787
100P300_19829295_ChIP-Seq_ESCs_Human1.21131824
101GATA1_22025678_ChIP-Seq_K562_Human1.20778531
102TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20339974
103* KDM2B_26808549_Chip-Seq_REH_Human1.20267036
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20169612
105MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19873952
106CBX2_27304074_Chip-Seq_ESCs_Mouse1.19803466
107FOXM1_23109430_ChIP-Seq_U2OS_Human1.19639758
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19587023
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19526963
110SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.19340231
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19010587
112FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18855985
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17328902
114VDR_23849224_ChIP-Seq_CD4+_Human1.16478011
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15626746
116* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15533754
117* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15379600
118* FOXA1_25329375_ChIP-Seq_VCAP_Human1.15379600
119VDR_22108803_ChIP-Seq_LS180_Human1.15186979
120* SMAD4_21741376_ChIP-Seq_EPCs_Human1.13779144
121GABP_17652178_ChIP-ChIP_JURKAT_Human1.13676232
122RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13546962
123AR_20517297_ChIP-Seq_VCAP_Human1.12184238
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11977434
125* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10991851
126SMAD4_21799915_ChIP-Seq_A2780_Human1.10175432
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09763153
128TAF15_26573619_Chip-Seq_HEK293_Human1.09647359
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09449192
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09323136
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08292230
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08292230
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07885391
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06758705
135EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05875549
136* SOX2_19829295_ChIP-Seq_ESCs_Human1.05283859
137* NANOG_19829295_ChIP-Seq_ESCs_Human1.05283859
138POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05114871
139NCOR_22424771_ChIP-Seq_293T_Human1.04881126
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.03502160
141* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01501189
142KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00660632
143JUN_21703547_ChIP-Seq_K562_Human1.00638160
144MYC_18940864_ChIP-ChIP_HL60_Human0.99997000
145EST1_17652178_ChIP-ChIP_JURKAT_Human0.99926337
146GATA3_26560356_Chip-Seq_TH2_Human0.99782409
147KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99183270
148ER_23166858_ChIP-Seq_MCF-7_Human0.99036187
149* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98825779
150IRF1_19129219_ChIP-ChIP_H3396_Human0.98038640
151FOXP3_21729870_ChIP-Seq_TREG_Human0.97143922
152* CDX2_22108803_ChIP-Seq_LS180_Human0.97110153
153PIAS1_25552417_ChIP-Seq_VCAP_Human0.96838643
154FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95672051
155ELK4_26923725_Chip-Seq_MESODERM_Mouse0.91870365
156GATA3_21867929_ChIP-Seq_TH1_Mouse0.91439152
157* RUNX2_22187159_ChIP-Seq_PCA_Human0.91359254
158RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91020400
159GF1_26923725_Chip-Seq_HPCs_Mouse0.90535603

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.39970867
2MP0003718_maternal_effect4.24477234
3MP0005451_abnormal_body_composition4.16531288
4MP0009780_abnormal_chondrocyte_physiolo3.54594274
5MP0003646_muscle_fatigue3.31601242
6MP0006292_abnormal_olfactory_placode2.91523325
7MP0008877_abnormal_DNA_methylation2.84893228
8* MP0002736_abnormal_nociception_after2.83202362
9MP0003787_abnormal_imprinting2.78801258
10MP0003693_abnormal_embryo_hatching2.72832329
11* MP0001968_abnormal_touch/_nociception2.65922525
12* MP0001119_abnormal_female_reproductive2.59194389
13MP0005646_abnormal_pituitary_gland2.53848592
14MP0005410_abnormal_fertilization2.50819617
15MP0002160_abnormal_reproductive_system2.50053442
16MP0001873_stomach_inflammation2.49424365
17MP0010094_abnormal_chromosome_stability2.48561473
18MP0000569_abnormal_digit_pigmentation2.41928392
19MP0003111_abnormal_nucleus_morphology2.32757311
20MP0008872_abnormal_physiological_respon2.30350525
21MP0000566_synostosis2.28670581
22MP0001346_abnormal_lacrimal_gland2.11849474
23MP0002277_abnormal_respiratory_mucosa2.10207932
24MP0003315_abnormal_perineum_morphology2.06679604
25MP0002163_abnormal_gland_morphology2.04141689
26MP0002876_abnormal_thyroid_physiology2.02883553
27MP0000383_abnormal_hair_follicle2.02374425
28MP0005310_abnormal_salivary_gland2.02190121
29MP0008058_abnormal_DNA_repair2.01422901
30MP0001919_abnormal_reproductive_system2.01097862
31MP0003077_abnormal_cell_cycle1.91301901
32MP0009697_abnormal_copulation1.90801351
33MP0005075_abnormal_melanosome_morpholog1.90154059
34* MP0003699_abnormal_female_reproductive1.83910520
35MP0002210_abnormal_sex_determination1.82380346
36MP0000015_abnormal_ear_pigmentation1.73631214
37MP0002132_abnormal_respiratory_system1.71670466
38MP0005551_abnormal_eye_electrophysiolog1.70160871
39* MP0000427_abnormal_hair_cycle1.69671218
40MP0001929_abnormal_gametogenesis1.68550407
41MP0003121_genomic_imprinting1.68259619
42MP0001188_hyperpigmentation1.67804067
43* MP0005395_other_phenotype1.65394293
44MP0005379_endocrine/exocrine_gland_phen1.64571915
45MP0003195_calcinosis1.63889934
46MP0001986_abnormal_taste_sensitivity1.61239140
47MP0001727_abnormal_embryo_implantation1.60847052
48* MP0000653_abnormal_sex_gland1.60719165
49MP0005408_hypopigmentation1.59102856
50MP0001835_abnormal_antigen_presentation1.56437776
51MP0003136_yellow_coat_color1.56204480
52MP0002653_abnormal_ependyma_morphology1.53233722
53MP0004264_abnormal_extraembryonic_tissu1.51021207
54MP0003763_abnormal_thymus_physiology1.50928676
55MP0010678_abnormal_skin_adnexa1.48071024
56MP0009785_altered_susceptibility_to1.47298459
57MP0004147_increased_porphyrin_level1.45958214
58MP0003724_increased_susceptibility_to1.43233005
59MP0002735_abnormal_chemical_nociception1.41714986
60MP0001661_extended_life_span1.40625230
61MP0005671_abnormal_response_to1.39696737
62MP0005645_abnormal_hypothalamus_physiol1.39420411
63MP0001529_abnormal_vocalization1.39075416
64MP0005389_reproductive_system_phenotype1.37174166
65MP0002638_abnormal_pupillary_reflex1.36834426
66MP0002249_abnormal_larynx_morphology1.36518597
67MP0008007_abnormal_cellular_replicative1.31685195
68MP0005253_abnormal_eye_physiology1.30677620
69MP0008932_abnormal_embryonic_tissue1.28533353
70MP0008260_abnormal_autophagy1.27183025
71MP0005248_abnormal_Harderian_gland1.22911788
72MP0003941_abnormal_skin_development1.22391288
73MP0002751_abnormal_autonomic_nervous1.20656311
74MP0005647_abnormal_sex_gland1.20481531
75MP0004957_abnormal_blastocyst_morpholog1.18918335
76MP0001764_abnormal_homeostasis1.16546714
77MP0003937_abnormal_limbs/digits/tail_de1.15110945
78MP0002396_abnormal_hematopoietic_system1.14901537
79MP0004043_abnormal_pH_regulation1.14337197
80MP0000372_irregular_coat_pigmentation1.13001149
81* MP0001145_abnormal_male_reproductive1.09997305
82MP0000579_abnormal_nail_morphology1.09271154
83MP0002837_dystrophic_cardiac_calcinosis1.08480707
84MP0004510_myositis1.08150581
85* MP0002184_abnormal_innervation1.07610588
86* MP0000470_abnormal_stomach_morphology1.05565310
87MP0006072_abnormal_retinal_apoptosis1.02757661
88MP0009115_abnormal_fat_cell1.01408996
89MP0005387_immune_system_phenotype1.01362255
90MP0001790_abnormal_immune_system1.01362255
91MP0002006_tumorigenesis0.99185258
92MP0005000_abnormal_immune_tolerance0.98898992
93MP0009046_muscle_twitch0.98133225
94MP0005174_abnormal_tail_pigmentation0.96924293
95* MP0000490_abnormal_crypts_of0.96146981
96MP0004145_abnormal_muscle_electrophysio0.96071222
97MP0001502_abnormal_circadian_rhythm0.96036934
98* MP0002161_abnormal_fertility/fecundity0.95591441
99MP0001485_abnormal_pinna_reflex0.95475562
100MP0002177_abnormal_outer_ear0.95318064
101MP0005377_hearing/vestibular/ear_phenot0.94743197
102MP0003878_abnormal_ear_physiology0.94743197
103MP0002148_abnormal_hypersensitivity_rea0.93074234
104* MP0000538_abnormal_urinary_bladder0.91942025
105MP0002909_abnormal_adrenal_gland0.91834959
106MP0000631_abnormal_neuroendocrine_gland0.90940938
107MP0000639_abnormal_adrenal_gland0.90621518
108MP0002419_abnormal_innate_immunity0.90347700
109MP0008995_early_reproductive_senescence0.88733820
110MP0001800_abnormal_humoral_immune0.87582736
111MP0002452_abnormal_antigen_presenting0.87564280
112MP0009672_abnormal_birth_weight0.87272623
113MP0005220_abnormal_exocrine_pancreas0.86986904
114MP0008057_abnormal_DNA_replication0.86319496
115* MP0010386_abnormal_urinary_bladder0.85631426
116MP0002095_abnormal_skin_pigmentation0.85617857
117MP0001186_pigmentation_phenotype0.85406663
118* MP0002229_neurodegeneration0.84493965
119MP0002723_abnormal_immune_serum0.83635473
120MP0004142_abnormal_muscle_tone0.82050924
121* MP0004782_abnormal_surfactant_physiolog0.81516630
122MP0001819_abnormal_immune_cell0.81116059
123MP0003786_premature_aging0.81069012
124MP0000678_abnormal_parathyroid_gland0.80795262
125MP0009703_decreased_birth_body0.80383786
126MP0002420_abnormal_adaptive_immunity0.79698584
127MP0009764_decreased_sensitivity_to0.79261739
128MP0000613_abnormal_salivary_gland0.79035466
129* MP0002693_abnormal_pancreas_physiology0.77385044
130MP0005636_abnormal_mineral_homeostasis0.77179460
131MP0003123_paternal_imprinting0.76547523
132MP0002405_respiratory_system_inflammati0.75998973
133MP0002928_abnormal_bile_duct0.75651631
134MP0005257_abnormal_intraocular_pressure0.75599314
135MP0001486_abnormal_startle_reflex0.74949469
136* MP0004484_altered_response_of0.74717936
137* MP0003936_abnormal_reproductive_system0.73959739
138MP0008789_abnormal_olfactory_epithelium0.73071450
139MP0010307_abnormal_tumor_latency0.72773648
140* MP0003698_abnormal_male_reproductive0.72618534
141MP0005409_darkened_coat_color0.72347579
142MP0005025_abnormal_response_to0.72328543
143MP0006276_abnormal_autonomic_nervous0.71395136
144MP0005083_abnormal_biliary_tract0.70149876
145* MP0002557_abnormal_social/conspecific_i0.68960876
146MP0000465_gastrointestinal_hemorrhage0.67369520
147MP0003890_abnormal_embryonic-extraembry0.67231134
148MP0000371_diluted_coat_color0.67044870
149MP0009745_abnormal_behavioral_response0.66121774
150* MP0002019_abnormal_tumor_incidence0.65612408
151MP0004381_abnormal_hair_follicle0.65490891
152MP0000858_altered_metastatic_potential0.65438766
153MP0010329_abnormal_lipoprotein_level0.64967726
154MP0006082_CNS_inflammation0.64903075
155* MP0000026_abnormal_inner_ear0.64897788
156MP0003656_abnormal_erythrocyte_physiolo0.64041733
157* MP0002734_abnormal_mechanical_nocicepti0.63478010
158MP0001984_abnormal_olfaction0.62759543
159MP0005171_absent_coat_pigmentation0.60264723

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.00088362
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.85592825
3Male infertility (HP:0003251)4.59560410
4Retrobulbar optic neuritis (HP:0100654)4.10817344
5Optic neuritis (HP:0100653)4.10817344
6Prostate neoplasm (HP:0100787)3.89910611
7Birth length less than 3rd percentile (HP:0003561)3.89325156
8Testicular neoplasm (HP:0010788)3.84645603
9Papillary thyroid carcinoma (HP:0002895)3.72719768
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.60662994
11Aplasia/Hypoplasia of the fovea (HP:0008060)3.52444236
12Hypoplasia of the fovea (HP:0007750)3.52444236
13Attenuation of retinal blood vessels (HP:0007843)3.28960666
14Hyperventilation (HP:0002883)3.10686626
15Orchitis (HP:0100796)3.08274460
16Hypergonadotropic hypogonadism (HP:0000815)2.99926027
17Premature ovarian failure (HP:0008209)2.92921281
18Abnormality of the fovea (HP:0000493)2.91722995
19Pulmonary fibrosis (HP:0002206)2.85015560
20Adrenal hypoplasia (HP:0000835)2.79244471
21Patellar aplasia (HP:0006443)2.72591839
22Hyperglycinuria (HP:0003108)2.71617288
23Congenital stationary night blindness (HP:0007642)2.69530078
24Myositis (HP:0100614)2.67211523
25Abnormality of the renal cortex (HP:0011035)2.67206222
26Breast hypoplasia (HP:0003187)2.66334915
27Abnormality of the prostate (HP:0008775)2.66048304
28Recurrent abscess formation (HP:0002722)2.60659666
29Bony spicule pigmentary retinopathy (HP:0007737)2.56189051
30Gaze-evoked nystagmus (HP:0000640)2.53484226
31Aplasia/Hypoplasia of the tongue (HP:0010295)2.52195027
32J-shaped sella turcica (HP:0002680)2.50421461
33Concave nail (HP:0001598)2.49671788
34Infertility (HP:0000789)2.49362954
35Oligodactyly (hands) (HP:0001180)2.47728949
36Abnormality of the parathyroid morphology (HP:0011766)2.45022740
37Aplasia/Hypoplasia of the patella (HP:0006498)2.44682391
38Abnormality of chromosome stability (HP:0003220)2.44030473
39Genetic anticipation (HP:0003743)2.40822662
40Protruding tongue (HP:0010808)2.39079604
41Genital tract atresia (HP:0001827)2.37594993
42Pancreatic fibrosis (HP:0100732)2.36919616
43Breast carcinoma (HP:0003002)2.36907047
44Cystic liver disease (HP:0006706)2.35634478
45Abnormality of the preputium (HP:0100587)2.34618564
46Abnormal rod and cone electroretinograms (HP:0008323)2.34326454
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.33100654
48Ectopic kidney (HP:0000086)2.32422555
49Abnormality of glycine metabolism (HP:0010895)2.32165871
50Abnormality of serine family amino acid metabolism (HP:0010894)2.32165871
51Keratoconjunctivitis sicca (HP:0001097)2.31396492
52Medial flaring of the eyebrow (HP:0010747)2.31323928
53Type 2 muscle fiber atrophy (HP:0003554)2.29830221
54Absent hand (HP:0004050)2.28607526
55Azoospermia (HP:0000027)2.27782889
56Enlarged penis (HP:0000040)2.27368570
57Abnormality of the pubic bones (HP:0003172)2.27123591
58Type II lissencephaly (HP:0007260)2.25766741
59Vaginal atresia (HP:0000148)2.25703549
60Large for gestational age (HP:0001520)2.25466577
61Abnormality of the labia minora (HP:0012880)2.23490603
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22300871
63Clubbing of toes (HP:0100760)2.22104273
64Congenital sensorineural hearing impairment (HP:0008527)2.21742542
65Abnormal spermatogenesis (HP:0008669)2.21254345
66Tetany (HP:0001281)2.20943750
67Methylmalonic acidemia (HP:0002912)2.19053886
68Bifid tongue (HP:0010297)2.17620553
69Abnormal respiratory motile cilium physiology (HP:0012261)2.17415802
70Atelectasis (HP:0100750)2.17297218
71Abnormality of the fingertips (HP:0001211)2.15167459
72Keratoconjunctivitis (HP:0001096)2.14104594
73Bile duct proliferation (HP:0001408)2.13521876
74Abnormal biliary tract physiology (HP:0012439)2.13521876
75Midline defect of the nose (HP:0004122)2.13080756
76Abnormal sex determination (HP:0012244)2.13022525
77Sex reversal (HP:0012245)2.13022525
78Congenital ichthyosiform erythroderma (HP:0007431)2.12946763
79Acute myeloid leukemia (HP:0004808)2.11603611
80Recurrent bacterial skin infections (HP:0005406)2.10120302
81Abnormality of the renal medulla (HP:0100957)2.09522137
82Abolished electroretinogram (ERG) (HP:0000550)2.08004120
83Male pseudohermaphroditism (HP:0000037)2.07842376
84Ketosis (HP:0001946)2.07240536
85True hermaphroditism (HP:0010459)2.06643113
86Gonadotropin excess (HP:0000837)2.05406913
87Chronic hepatic failure (HP:0100626)2.05378370
88Bicornuate uterus (HP:0000813)2.03951594
89Meckel diverticulum (HP:0002245)2.03113873
90Morphological abnormality of the middle ear (HP:0008609)2.01863102
91Abnormality of macular pigmentation (HP:0008002)2.01722293
92Aplasia/Hypoplasia of the macula (HP:0008059)2.01184057
93Eczematoid dermatitis (HP:0000976)2.00018626
94Tubulointerstitial nephritis (HP:0001970)2.00006437
95Cerebellar dysplasia (HP:0007033)1.99550929
96Abnormality of lateral ventricle (HP:0030047)1.98906669
97Duodenal stenosis (HP:0100867)1.98320841
98Small intestinal stenosis (HP:0012848)1.98320841
99Bilateral microphthalmos (HP:0007633)1.97879094
100Abnormality of incisor morphology (HP:0011063)1.97814029
101Pendular nystagmus (HP:0012043)1.97224401
102Abnormality of midbrain morphology (HP:0002418)1.96993435
103Molar tooth sign on MRI (HP:0002419)1.96993435
104Abnormal protein glycosylation (HP:0012346)1.96734453
105Abnormal glycosylation (HP:0012345)1.96734453
106Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96734453
107Abnormal protein N-linked glycosylation (HP:0012347)1.96734453
108Cupped ear (HP:0000378)1.96173917
109Abnormal drinking behavior (HP:0030082)1.95875413
110Polydipsia (HP:0001959)1.95875413
111Septo-optic dysplasia (HP:0100842)1.95569206
112Progressive cerebellar ataxia (HP:0002073)1.95504219
113Volvulus (HP:0002580)1.95483587
114Proximal tubulopathy (HP:0000114)1.94331098
115Pancreatic cysts (HP:0001737)1.93619889
116Renal cortical cysts (HP:0000803)1.92497178
117Shawl scrotum (HP:0000049)1.92128132
118Absent septum pellucidum (HP:0001331)1.91375459
119Thyroid carcinoma (HP:0002890)1.91233865
120Abnormality of male internal genitalia (HP:0000022)1.89083392
121Secondary amenorrhea (HP:0000869)1.88910447
122Increased neuronal autofluorescent lipopigment (HP:0002074)1.88630551
123Capillary hemangiomas (HP:0005306)1.88456115
124Macroorchidism (HP:0000053)1.87450481
125Furrowed tongue (HP:0000221)1.87038995
126Intestinal atresia (HP:0011100)1.86797921
127Absent/shortened dynein arms (HP:0200106)1.86442628
128Dynein arm defect of respiratory motile cilia (HP:0012255)1.86442628
129Ketoacidosis (HP:0001993)1.86388875
130Abnormality of the pons (HP:0007361)1.86335648
131Breast aplasia (HP:0100783)1.86103986
132Oligodactyly (HP:0012165)1.85653546
133Abnormal ciliary motility (HP:0012262)1.85463930
134Recurrent pneumonia (HP:0006532)1.84998544
135Anomalous pulmonary venous return (HP:0010772)1.84010220
136Abnormality of the renal collecting system (HP:0004742)1.82860051
137Combined immunodeficiency (HP:0005387)1.82583111
138Flat capital femoral epiphysis (HP:0003370)1.82543184
139Germ cell neoplasia (HP:0100728)1.81831459
140High pitched voice (HP:0001620)1.81710450
141Abnormality of the ileum (HP:0001549)1.81682180
142Type I transferrin isoform profile (HP:0003642)1.81064188
143Muscle fiber atrophy (HP:0100295)1.80837753
144Hypothermia (HP:0002045)1.80609333
145Congenital primary aphakia (HP:0007707)1.80201276
146Gait imbalance (HP:0002141)1.79775645
147Abnormality of the intervertebral disk (HP:0005108)1.79690787
148Astigmatism (HP:0000483)1.79509248
149Methylmalonic aciduria (HP:0012120)1.79196674
150Nephronophthisis (HP:0000090)1.79090765
151Aplasia/Hypoplasia of the tibia (HP:0005772)1.78873783
152Occipital encephalocele (HP:0002085)1.78853993
153Aplasia/Hypoplasia of the breasts (HP:0010311)1.77255706
154Abnormality of the phalanges of the hallux (HP:0010057)1.75970340
155Encephalitis (HP:0002383)1.75760508
156Febrile seizures (HP:0002373)1.75456617
157Testicular atrophy (HP:0000029)1.75381995
158Asymmetry of the thorax (HP:0001555)1.75349176
159Severe combined immunodeficiency (HP:0004430)1.74509130
160Supernumerary spleens (HP:0009799)1.74486191
161Nephrogenic diabetes insipidus (HP:0009806)1.74153126
162Osteomalacia (HP:0002749)1.73791486
163Short tibia (HP:0005736)1.73773015
164Aplasia/Hypoplasia of the sternum (HP:0006714)1.73419012
165Absent eyebrow (HP:0002223)1.73096154
166Abnormality of the septum pellucidum (HP:0007375)1.72031645
167Pulmonary infiltrates (HP:0002113)1.70788141
168Anophthalmia (HP:0000528)1.69964917
169Nonprogressive disorder (HP:0003680)1.69835966
170Postaxial foot polydactyly (HP:0001830)1.69671453
171Tubular atrophy (HP:0000092)1.69451444
172Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69303169
173Abnormality of alanine metabolism (HP:0010916)1.69303169
174Hyperalaninemia (HP:0003348)1.69303169
175Bronchiectasis (HP:0002110)1.69228537
176IgG deficiency (HP:0004315)1.68968836
177Chronic mucocutaneous candidiasis (HP:0002728)1.68575359
178Recurrent cutaneous fungal infections (HP:0011370)1.68575359
179Absent frontal sinuses (HP:0002688)1.68537304
180Sclerocornea (HP:0000647)1.66711080
181Abnormal hair whorl (HP:0010721)1.66595754
182Widely spaced teeth (HP:0000687)1.66068827

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.86669371
2TRIB33.73414149
3PLK43.59167901
4LATS13.55729317
5MUSK3.21146890
6STK38L3.21090705
7BMPR22.91419182
8TAOK32.83731695
9STK392.73838899
10ERBB42.61312605
11MAP3K62.60218379
12MAP4K22.48648720
13CDK82.31234811
14OXSR12.31142957
15ACVR1B2.27878666
16TTK2.26703514
17NUAK12.24439085
18TRIM282.24344955
19LATS22.12933562
20BRAF2.11947434
21FGFR22.08758057
22MAP3K132.06230252
23ZAK1.99998684
24MOS1.99515766
25CDC71.88783906
26TXK1.88215820
27FGFR41.74959391
28INSRR1.73688783
29DYRK21.72290679
30TIE11.70932616
31PIK3CA1.66450274
32BMPR1B1.64276952
33MAPK131.57859838
34TLK11.56105619
35MAP2K71.55315985
36EIF2AK31.50096072
37GRK51.47354399
38STK31.46919593
39MAP3K141.44440848
40IRAK31.43213520
41CDK91.36085016
42JAK31.34907640
43CASK1.34858863
44CHEK21.34573863
45WNK31.33104228
46EIF2AK21.32554173
47NLK1.30446755
48ITK1.26199057
49MST41.24396179
50MKNK21.20337353
51MAP3K121.15040130
52TNK21.14948434
53MAPKAPK31.11811007
54MELK1.09491536
55ILK1.09103440
56SGK21.08616984
57PLK11.08076533
58SRPK11.04345175
59GRK61.03959856
60BLK1.02912318
61CDK31.01420373
62CHUK0.99983136
63IKBKE0.98813428
64TEC0.98492978
65STK240.93971161
66PRKCI0.93920325
67NEK60.92357390
68PRKD30.92283739
69BCR0.88934398
70WNK40.87823151
71MARK30.86390605
72SCYL20.86174642
73TNIK0.85695114
74RPS6KA20.84582896
75NTRK20.83823311
76RET0.81818863
77YES10.80172721
78MAP3K40.79928867
79IRAK40.79292965
80NEK90.78425901
81PINK10.76441490
82TRPM70.76020194
83RPS6KB10.75757449
84MAP4K10.73653359
85RPS6KA60.73442413
86EPHA30.72968636
87RAF10.72145031
88CSNK1G10.71328890
89VRK10.71179852
90CDK70.70968882
91PRKD20.70468602
92AKT30.67482018
93NTRK30.66930062
94AURKB0.65710660
95PDK10.65092914
96CSNK1D0.64934413
97MYLK0.64240268
98CAMKK10.63740890
99PLK30.62403388
100MKNK10.62349255
101ATM0.62245629
102CSNK1A1L0.61394519
103ABL20.60832671
104STK380.58515080
105RPS6KL10.58189133
106RPS6KC10.58189133
107EIF2AK10.57785699
108ARAF0.57472249
109ADRBK20.56731800
110GRK10.55552098
111IRAK10.55452158
112ATR0.54224902
113FER0.53559484
114AKT20.52563209
115AURKA0.51722919
116PAK30.51624190
117TBK10.50901178
118CSNK1G30.50399531
119IKBKB0.50297723
120PDK20.49209208
121MAP3K50.48407125
122PLK20.46766324
123SIK30.46497087
124STK160.45935197
125STK100.43553131
126ERBB30.43411593
127PRKCE0.43269088
128BCKDK0.42922573
129DMPK0.42914406
130KSR20.42902889
131SGK4940.42722912
132SGK2230.42722912
133NEK20.42296125
134RPS6KA50.41543280
135PRKCZ0.40490337
136CSNK1A10.38619459
137FRK0.36910753
138CHEK10.36803175
139MAPKAPK50.36065652
140TAOK10.36011086
141PRKD10.35783101
142PIK3CG0.35707954
143SGK30.34937351
144CSNK1G20.34877610
145SIK20.34388139
146PNCK0.34132661
147BUB10.33954343
148SYK0.32205836
149EEF2K0.31860861
150BRD40.31341873
151MAPK110.31172625
152LCK0.30887316
153PRKAA10.29628934
154PRKCQ0.29041055
155KIT0.27211818
156PRKAA20.27191335

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049133.34256660
2Basal transcription factors_Homo sapiens_hsa030222.94121943
3Butanoate metabolism_Homo sapiens_hsa006502.91549011
4RNA degradation_Homo sapiens_hsa030182.83758639
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.80850087
6Homologous recombination_Homo sapiens_hsa034402.77620728
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65332245
8Fanconi anemia pathway_Homo sapiens_hsa034602.63285489
9Cell cycle_Homo sapiens_hsa041102.60047863
10ABC transporters_Homo sapiens_hsa020102.44629748
11Non-homologous end-joining_Homo sapiens_hsa034502.39153910
12RNA polymerase_Homo sapiens_hsa030202.26104493
13Propanoate metabolism_Homo sapiens_hsa006402.11874285
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10294382
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06584173
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06446980
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.99451658
18Base excision repair_Homo sapiens_hsa034101.89703820
19Graft-versus-host disease_Homo sapiens_hsa053321.88074654
20Selenocompound metabolism_Homo sapiens_hsa004501.65689880
21Ether lipid metabolism_Homo sapiens_hsa005651.64240574
22Allograft rejection_Homo sapiens_hsa053301.63073225
23Linoleic acid metabolism_Homo sapiens_hsa005911.62670970
24p53 signaling pathway_Homo sapiens_hsa041151.60812827
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59129008
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.56713176
27Circadian rhythm_Homo sapiens_hsa047101.56472126
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.54335253
29Vitamin B6 metabolism_Homo sapiens_hsa007501.43768821
30beta-Alanine metabolism_Homo sapiens_hsa004101.43407623
31Caffeine metabolism_Homo sapiens_hsa002321.41975440
32Other glycan degradation_Homo sapiens_hsa005111.39683058
33TGF-beta signaling pathway_Homo sapiens_hsa043501.35646656
34Nitrogen metabolism_Homo sapiens_hsa009101.35605022
35Rheumatoid arthritis_Homo sapiens_hsa053231.34687409
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34212581
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32285490
38Primary immunodeficiency_Homo sapiens_hsa053401.29942403
39Mismatch repair_Homo sapiens_hsa034301.28659771
40Herpes simplex infection_Homo sapiens_hsa051681.28363773
41Autoimmune thyroid disease_Homo sapiens_hsa053201.27091924
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22412553
43Nucleotide excision repair_Homo sapiens_hsa034201.20505535
44Pyrimidine metabolism_Homo sapiens_hsa002401.18381001
45Measles_Homo sapiens_hsa051621.17865515
46Olfactory transduction_Homo sapiens_hsa047401.16180096
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14104049
48Hematopoietic cell lineage_Homo sapiens_hsa046401.13322467
49DNA replication_Homo sapiens_hsa030301.11624625
50Lysine degradation_Homo sapiens_hsa003101.10706837
51Type I diabetes mellitus_Homo sapiens_hsa049401.10143918
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09201907
53Arachidonic acid metabolism_Homo sapiens_hsa005901.06729203
54Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04840751
55Pancreatic cancer_Homo sapiens_hsa052121.03185772
56Tryptophan metabolism_Homo sapiens_hsa003801.03140235
57Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02143499
58Leishmaniasis_Homo sapiens_hsa051401.01681497
59Purine metabolism_Homo sapiens_hsa002301.01166047
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99139867
61Fatty acid metabolism_Homo sapiens_hsa012120.98610938
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95884784
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95153551
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94476390
65One carbon pool by folate_Homo sapiens_hsa006700.93930388
66RNA transport_Homo sapiens_hsa030130.88363187
67TNF signaling pathway_Homo sapiens_hsa046680.88318972
68mTOR signaling pathway_Homo sapiens_hsa041500.87313591
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86710464
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.86642774
71Influenza A_Homo sapiens_hsa051640.85612500
72Malaria_Homo sapiens_hsa051440.84117980
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84107847
74Salivary secretion_Homo sapiens_hsa049700.83572210
75Peroxisome_Homo sapiens_hsa041460.83046139
76Chemical carcinogenesis_Homo sapiens_hsa052040.81902271
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.80086825
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.79768422
79Hepatitis B_Homo sapiens_hsa051610.76201991
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75638393
81Insulin resistance_Homo sapiens_hsa049310.73095166
82Melanoma_Homo sapiens_hsa052180.72518275
83B cell receptor signaling pathway_Homo sapiens_hsa046620.71381175
84MicroRNAs in cancer_Homo sapiens_hsa052060.71211095
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71191632
86Epstein-Barr virus infection_Homo sapiens_hsa051690.70837955
87Legionellosis_Homo sapiens_hsa051340.70687339
88N-Glycan biosynthesis_Homo sapiens_hsa005100.70182655
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68894668
90mRNA surveillance pathway_Homo sapiens_hsa030150.68312818
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64568095
92Glucagon signaling pathway_Homo sapiens_hsa049220.63298845
93Oocyte meiosis_Homo sapiens_hsa041140.63088493
94AMPK signaling pathway_Homo sapiens_hsa041520.62718376
95HTLV-I infection_Homo sapiens_hsa051660.62142977
96Insulin secretion_Homo sapiens_hsa049110.61581066
97* Prolactin signaling pathway_Homo sapiens_hsa049170.61539222
98Notch signaling pathway_Homo sapiens_hsa043300.60969497
99Colorectal cancer_Homo sapiens_hsa052100.59545052
100Nicotine addiction_Homo sapiens_hsa050330.58920399
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.58757837
102Cholinergic synapse_Homo sapiens_hsa047250.58637873
103Protein export_Homo sapiens_hsa030600.58150029
104Serotonergic synapse_Homo sapiens_hsa047260.57101140
105Choline metabolism in cancer_Homo sapiens_hsa052310.56775070
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54248825
107Regulation of autophagy_Homo sapiens_hsa041400.53308980
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52793335
109Asthma_Homo sapiens_hsa053100.52658297
110FoxO signaling pathway_Homo sapiens_hsa040680.52238202
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52133081
112Ras signaling pathway_Homo sapiens_hsa040140.51741786
113Sphingolipid metabolism_Homo sapiens_hsa006000.51713956
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51398036
115Apoptosis_Homo sapiens_hsa042100.49840072
116Tuberculosis_Homo sapiens_hsa051520.49818610
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49449424
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.48853873
119Inositol phosphate metabolism_Homo sapiens_hsa005620.48320605
120Metabolic pathways_Homo sapiens_hsa011000.47714818
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47435039
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46148866
123Small cell lung cancer_Homo sapiens_hsa052220.45820353
124Hippo signaling pathway_Homo sapiens_hsa043900.45447193
125Chemokine signaling pathway_Homo sapiens_hsa040620.45221625
126Phagosome_Homo sapiens_hsa041450.44659695
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44534681
128Histidine metabolism_Homo sapiens_hsa003400.44169311
129Phenylalanine metabolism_Homo sapiens_hsa003600.43587054
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42430068
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41995272
132Shigellosis_Homo sapiens_hsa051310.41946959
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41674098
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.41612443
135T cell receptor signaling pathway_Homo sapiens_hsa046600.40451693
136Taste transduction_Homo sapiens_hsa047420.40339603
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38612219
138Proteasome_Homo sapiens_hsa030500.38496921
139Dorso-ventral axis formation_Homo sapiens_hsa043200.38347561
140Fatty acid elongation_Homo sapiens_hsa000620.38053211
141Phototransduction_Homo sapiens_hsa047440.37483681
142Endometrial cancer_Homo sapiens_hsa052130.36104800
143GnRH signaling pathway_Homo sapiens_hsa049120.34850426
144Prostate cancer_Homo sapiens_hsa052150.34746379
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34682083
146Calcium signaling pathway_Homo sapiens_hsa040200.34428038
147Glycerolipid metabolism_Homo sapiens_hsa005610.34403151
148Toxoplasmosis_Homo sapiens_hsa051450.34401116
149Fatty acid biosynthesis_Homo sapiens_hsa000610.33782577
150Glutathione metabolism_Homo sapiens_hsa004800.33290460

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