ESRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.76670770
2regulation of water loss via skin (GO:0033561)7.29702601
3hemidesmosome assembly (GO:0031581)7.25919914
4intestinal epithelial cell development (GO:0060576)7.09779334
5establishment of skin barrier (GO:0061436)6.98334412
6bundle of His cell to Purkinje myocyte communication (GO:0086069)6.14797513
7Golgi transport vesicle coating (GO:0048200)5.88274823
8COPI coating of Golgi vesicle (GO:0048205)5.88274823
9keratinization (GO:0031424)5.85141946
10multicellular organismal water homeostasis (GO:0050891)5.51107683
11interferon-gamma secretion (GO:0072643)5.00220130
12negative regulation of keratinocyte proliferation (GO:0010839)4.96176269
13hair cycle (GO:0042633)4.76865577
14molting cycle (GO:0042303)4.76865577
15columnar/cuboidal epithelial cell development (GO:0002066)4.69811945
16keratinocyte differentiation (GO:0030216)4.69232816
17glandular epithelial cell differentiation (GO:0002067)4.62346021
18water homeostasis (GO:0030104)4.54710758
19keratinocyte development (GO:0003334)4.39009807
20epidermal cell differentiation (GO:0009913)3.98956060
21ectoderm development (GO:0007398)3.96011177
22sphingosine metabolic process (GO:0006670)3.95223351
23regulation of keratinocyte proliferation (GO:0010837)3.88025021
24tight junction assembly (GO:0070830)3.82856671
25regulation of DNA methylation (GO:0044030)3.78640237
26sphingoid metabolic process (GO:0046519)3.77839712
27diol metabolic process (GO:0034311)3.76905865
28nuclear pore complex assembly (GO:0051292)3.74238372
29oocyte development (GO:0048599)3.72483066
30keratinocyte proliferation (GO:0043616)3.69749798
31gap junction assembly (GO:0016264)3.65198946
32type B pancreatic cell development (GO:0003323)3.64319529
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.64093271
34nuclear pore organization (GO:0006999)3.61468784
35COPII vesicle coating (GO:0048208)3.56027424
36intermediate filament organization (GO:0045109)3.54159892
37paraxial mesoderm development (GO:0048339)3.50445201
38pre-miRNA processing (GO:0031054)3.48965167
39protein localization to kinetochore (GO:0034501)3.48923535
40regulation of acrosome reaction (GO:0060046)3.42402376
41positive regulation of Cdc42 GTPase activity (GO:0043089)3.42314003
42endocrine pancreas development (GO:0031018)3.41320764
43protein complex localization (GO:0031503)3.40385657
44mitotic metaphase plate congression (GO:0007080)3.35657133
45glandular epithelial cell development (GO:0002068)3.35442408
46intestinal absorption (GO:0050892)3.33273539
47regulation of histone H3-K9 methylation (GO:0051570)3.33170734
48trophectodermal cell differentiation (GO:0001829)3.31326061
49UDP-N-acetylglucosamine metabolic process (GO:0006047)3.29022713
50establishment of integrated proviral latency (GO:0075713)3.28403281
51epidermis development (GO:0008544)3.24719825
52membrane budding (GO:0006900)3.24388106
53negative regulation of cell fate specification (GO:0009996)3.21265666
54positive regulation of chromosome segregation (GO:0051984)3.19823284
55activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.19642972
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.17651230
57mitotic sister chromatid cohesion (GO:0007064)3.17399399
58protein retention in ER lumen (GO:0006621)3.12894293
59positive regulation of epidermal cell differentiation (GO:0045606)3.11604317
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10970205
61positive regulation of nuclease activity (GO:0032075)3.08254335
62dorsal/ventral axis specification (GO:0009950)3.07211347
63regulation of gene silencing by miRNA (GO:0060964)3.06529355
64regulation of gene silencing by RNA (GO:0060966)3.06529355
65regulation of posttranscriptional gene silencing (GO:0060147)3.06529355
66regulation of hippo signaling (GO:0035330)3.06040953
67peptide cross-linking (GO:0018149)3.05975408
68regulation of cardioblast differentiation (GO:0051890)3.04198431
69exocrine pancreas development (GO:0031017)3.00885568
70protein localization to chromosome, centromeric region (GO:0071459)2.99155345
71nodal signaling pathway (GO:0038092)2.93941360
72regulation of centriole replication (GO:0046599)2.92952339
73nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.91113252
74metaphase plate congression (GO:0051310)2.90094037
75regulation of cell fate specification (GO:0042659)2.89290960
76nucleotide-sugar biosynthetic process (GO:0009226)2.88628486
77ribosome assembly (GO:0042255)2.87377978
78regulation of chemokine secretion (GO:0090196)2.87260774
79regulation of nuclease activity (GO:0032069)2.86941000
80L-alpha-amino acid transmembrane transport (GO:1902475)2.86491457
81regulation of keratinocyte differentiation (GO:0045616)2.86082941
82cellular response to vitamin D (GO:0071305)2.81951518
83positive regulation of histone H3-K4 methylation (GO:0051571)2.80494816
84cellular protein complex localization (GO:0034629)2.80329422
85calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.79922027
86epithelial cell maturation (GO:0002070)2.79714108
87negative regulation of cell fate commitment (GO:0010454)2.79436497
88gland morphogenesis (GO:0022612)2.79303220
89epithelial cell-cell adhesion (GO:0090136)2.77877970
90anterior/posterior axis specification, embryo (GO:0008595)2.77583883
91regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.76670473
92establishment of tissue polarity (GO:0007164)2.75950536
93establishment of planar polarity (GO:0001736)2.75950536
94regulation of chromatin silencing (GO:0031935)2.74929048
95regulation of transforming growth factor beta2 production (GO:0032909)2.74753567
96mitotic chromosome condensation (GO:0007076)2.72143357
97regulation of Cdc42 GTPase activity (GO:0043088)2.67894488
98negative regulation of epidermis development (GO:0045683)2.67394009
99ventricular cardiac muscle cell action potential (GO:0086005)2.67187334
100telomere maintenance via telomerase (GO:0007004)2.66583664
101L-serine metabolic process (GO:0006563)2.66306706
102skin morphogenesis (GO:0043589)2.65888874
103endoplasmic reticulum unfolded protein response (GO:0030968)2.64889883
104establishment of apical/basal cell polarity (GO:0035089)2.64649806
105positive regulation of epidermis development (GO:0045684)2.64053730
106regulation of meiosis I (GO:0060631)2.63769762
107phosphatidylinositol acyl-chain remodeling (GO:0036149)2.63326679
108polarized epithelial cell differentiation (GO:0030859)2.62177931
109negative regulation of DNA repair (GO:0045738)2.61215227
110RNA-dependent DNA replication (GO:0006278)2.61175426
111DNA replication checkpoint (GO:0000076)2.60304222
112genitalia morphogenesis (GO:0035112)2.60213407
113cellular response to unfolded protein (GO:0034620)2.59069427
114CENP-A containing nucleosome assembly (GO:0034080)2.58350951
115morphogenesis of embryonic epithelium (GO:0016331)2.58270293
116regulation of helicase activity (GO:0051095)2.58177362
117regulation of sister chromatid cohesion (GO:0007063)2.57704317
118pore complex assembly (GO:0046931)2.53019702
119phosphatidylserine acyl-chain remodeling (GO:0036150)2.52636703
120chromatin remodeling at centromere (GO:0031055)2.51832088
121positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.50807576
122positive regulation of cell cycle G2/M phase transition (GO:1902751)2.50807576
123surfactant homeostasis (GO:0043129)2.50343930
124regulation of epidermis development (GO:0045682)2.49488111
125piRNA metabolic process (GO:0034587)2.48451544
126peptide hormone processing (GO:0016486)2.48177599
127regulation of epidermal cell differentiation (GO:0045604)2.47263057
128regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.47124988
129ER-nucleus signaling pathway (GO:0006984)2.46967321
130phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.46899014
131heterochromatin organization (GO:0070828)2.45589275
132cardiac right ventricle morphogenesis (GO:0003215)2.45201133
133intermediate filament cytoskeleton organization (GO:0045104)2.44983284
134cellular response to topologically incorrect protein (GO:0035967)2.44551484
135intestinal cholesterol absorption (GO:0030299)2.43773095
136cell-cell junction assembly (GO:0007043)2.43559028
137positive regulation of mitotic sister chromatid separation (GO:1901970)2.42760439
138positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.42760439
139positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.42760439
140meiotic cell cycle (GO:0051321)2.41839314
141chemical homeostasis within a tissue (GO:0048875)2.41190190
142negative regulation of histone methylation (GO:0031061)2.40726320
143regulation of chromosome segregation (GO:0051983)2.40684512
144positive regulation of interleukin-8 secretion (GO:2000484)2.39337952
145establishment or maintenance of bipolar cell polarity (GO:0061245)2.39239030
146establishment or maintenance of apical/basal cell polarity (GO:0035088)2.39239030
147SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.38381024
148apical protein localization (GO:0045176)2.37880466
149establishment of chromosome localization (GO:0051303)2.36965634
150phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.36907494
151histone H2A monoubiquitination (GO:0035518)2.36622878
152female gonad development (GO:0008585)2.36469032
153regulation of gene silencing (GO:0060968)2.36399230
154planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36073401
155intermediate filament-based process (GO:0045103)2.35300456
156regulation of transforming growth factor beta1 production (GO:0032908)2.35256069
157epithelial cell fate commitment (GO:0072148)2.35191757
158hippo signaling (GO:0035329)2.34897961
159notochord development (GO:0030903)2.34658946
160establishment of epithelial cell polarity (GO:0090162)2.34497724
161positive regulation of hormone biosynthetic process (GO:0046886)2.34278868
162protein targeting to ER (GO:0045047)2.34250356
163response to X-ray (GO:0010165)2.32994985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.82966164
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.98768482
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.38633927
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.23867983
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.93314378
6SOX2_27498859_Chip-Seq_STOMACH_Mouse2.68496146
7ZNF263_19887448_ChIP-Seq_K562_Human2.60158585
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55620519
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.44387756
10GATA6_25053715_ChIP-Seq_YYC3_Human2.37838420
11SOX9_24532713_ChIP-Seq_HFSC_Mouse2.33995982
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.30365250
13FOXO3_23340844_ChIP-Seq_DLD1_Human2.25294702
14P63_26484246_Chip-Seq_KERATINOCYTES_Human2.12993966
15GATA4_25053715_ChIP-Seq_YYC3_Human2.12018518
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08397728
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.03618125
18TP63_17297297_ChIP-ChIP_HaCaT_Human12.6606452
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.99767972
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.94636556
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.93447624
22SOX2_20726797_ChIP-Seq_SW620_Human1.90781962
23* RUNX1_27514584_Chip-Seq_MCF-7_Human1.90163146
24SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.89465003
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.89465003
26AR_21909140_ChIP-Seq_LNCAP_Human1.88555780
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.87836520
28* ATF3_27146783_Chip-Seq_COLON_Human1.79630975
29* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76969025
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.74726732
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.74674585
32GATA3_24758297_ChIP-Seq_MCF-7_Human1.73165202
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71080541
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70540745
35ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.67880771
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67715946
37FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.66992178
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65577401
39FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.63284514
40NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.59766468
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56846788
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55742801
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55601215
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.55344498
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.55344498
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.55344498
47RACK7_27058665_Chip-Seq_MCF-7_Human1.54575393
48* CHD1_26751641_Chip-Seq_LNCaP_Human1.53021678
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47427934
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45759460
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.44880297
52KLF5_25053715_ChIP-Seq_YYC3_Human1.44038088
53ELF5_23300383_ChIP-Seq_T47D_Human1.43356984
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42783666
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41359156
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39875824
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.39251379
58EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.36439174
59* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35163270
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32902195
61GATA1_22025678_ChIP-Seq_K562_Human1.31776094
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30829535
63* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30385414
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.30328633
65FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.27864263
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27511036
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.22815980
68CLOCK_20551151_ChIP-Seq_293T_Human1.22231636
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21217419
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.20825317
71UBF1/2_26484160_Chip-Seq_HMECs_Human1.19928353
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.19077126
73AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18771877
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.17430975
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15052799
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14293363
77* TP63_23658742_ChIP-Seq_EP156T_Human1.12267138
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09451382
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08672805
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07183425
81NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.06470753
82MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06420990
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04028789
84TRIM28_21343339_ChIP-Seq_HEK293_Human1.03965637
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02762365
86* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02619110
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.02584842
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02295557
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01522659
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01314848
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00138096
92TP63_22573176_ChIP-Seq_HFKS_Human0.99911280
93AHR_22903824_ChIP-Seq_MCF-7_Human0.99755096
94FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99372953
95DCP1A_22483619_ChIP-Seq_HELA_Human0.99085510
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98538937
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97716792
98* FOXA1_25552417_ChIP-Seq_VCAP_Human0.97672912
99KDM5A_27292631_Chip-Seq_BREAST_Human0.97365521
100NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97343536
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95725226
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.95705407
103CDX2_22108803_ChIP-Seq_LS180_Human0.94238791
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93387445
105PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.92946957
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91149912
107* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91082220
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90870604
109CJUN_26792858_Chip-Seq_BT549_Human0.90734832
110ARNT_22903824_ChIP-Seq_MCF-7_Human0.90496670
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90311038
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89766115
113EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89258468
114NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89161735
115KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87111806
116TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86757136
117ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85242880
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.83611049
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82705130
120CREB1_26743006_Chip-Seq_LNCaP_Human0.82540663
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.81151646
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80295762
123MYC_19079543_ChIP-ChIP_MESCs_Mouse0.80259108
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.79221187
125TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.78685063
126P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76754200
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76411685
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75545284
129E2F1_21310950_ChIP-Seq_MCF-7_Human0.72662569
130* ERG_20517297_ChIP-Seq_VCAP_Human0.69978610
131FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.69942185
132UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.68728226
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66206540
134NANOG_18692474_ChIP-Seq_MESCs_Mouse0.65165421

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.70585115
2MP0002796_impaired_skin_barrier4.49099985
3MP0002254_reproductive_system_inflammat3.19578786
4MP0000579_abnormal_nail_morphology3.17621715
5MP0004264_abnormal_extraembryonic_tissu3.14534675
6MP0010678_abnormal_skin_adnexa3.01279106
7MP0002098_abnormal_vibrissa_morphology2.99213736
8MP0003941_abnormal_skin_development2.93139248
9MP0005275_abnormal_skin_tensile2.73554149
10MP0002877_abnormal_melanocyte_morpholog2.73244366
11MP0000383_abnormal_hair_follicle2.72081091
12MP0005501_abnormal_skin_physiology2.69266628
13MP0002060_abnormal_skin_morphology2.33632996
14MP0001216_abnormal_epidermal_layer2.33349374
15MP0001346_abnormal_lacrimal_gland2.22987498
16MP0003453_abnormal_keratinocyte_physiol2.15671679
17MP0000566_synostosis2.07735234
18MP0008057_abnormal_DNA_replication2.03456392
19MP0003705_abnormal_hypodermis_morpholog2.02016618
20MP0000462_abnormal_digestive_system1.97262424
21MP0010352_gastrointestinal_tract_polyps1.94387677
22MP0000647_abnormal_sebaceous_gland1.94146750
23MP0000377_abnormal_hair_follicle1.93949524
24MP0001849_ear_inflammation1.90534777
25MP0000427_abnormal_hair_cycle1.84908176
26MP0000537_abnormal_urethra_morphology1.83289618
27MP0000467_abnormal_esophagus_morphology1.77760466
28MP0003693_abnormal_embryo_hatching1.75973228
29MP0010771_integument_phenotype1.69219789
30MP0010094_abnormal_chromosome_stability1.69043565
31MP0003283_abnormal_digestive_organ1.68955336
32MP0000613_abnormal_salivary_gland1.67031038
33MP0002234_abnormal_pharynx_morphology1.61556241
34MP0003111_abnormal_nucleus_morphology1.59803824
35MP0003300_gastrointestinal_ulcer1.59447177
36MP0000762_abnormal_tongue_morphology1.58718420
37MP0003566_abnormal_cell_adhesion1.53393377
38MP0000678_abnormal_parathyroid_gland1.51085997
39MP0003077_abnormal_cell_cycle1.50273071
40MP0008932_abnormal_embryonic_tissue1.48567498
41MP0002009_preneoplasia1.47953146
42MP0004185_abnormal_adipocyte_glucose1.46939748
43MP0004947_skin_inflammation1.38061608
44MP0005076_abnormal_cell_differentiation1.36953411
45MP0005220_abnormal_exocrine_pancreas1.36077526
46MP0004381_abnormal_hair_follicle1.34286226
47MP0000516_abnormal_urinary_system1.31800266
48MP0005367_renal/urinary_system_phenotyp1.31800266
49MP0008058_abnormal_DNA_repair1.28734952
50MP0001944_abnormal_pancreas_morphology1.25777438
51MP0010307_abnormal_tumor_latency1.25602761
52MP0002693_abnormal_pancreas_physiology1.25599097
53MP0001666_abnormal_nutrient_absorption1.24751743
54MP0004957_abnormal_blastocyst_morpholog1.24048140
55MP0001672_abnormal_embryogenesis/_devel1.22706146
56MP0005380_embryogenesis_phenotype1.22706146
57MP0001188_hyperpigmentation1.18759959
58MP0005395_other_phenotype1.18480296
59MP0010030_abnormal_orbit_morphology1.17694784
60MP0000350_abnormal_cell_proliferation1.12454937
61MP0003890_abnormal_embryonic-extraembry1.10493005
62MP0000627_abnormal_mammary_gland1.10208433
63MP0003315_abnormal_perineum_morphology1.08841539
64MP0009780_abnormal_chondrocyte_physiolo1.05929771
65MP0005187_abnormal_penis_morphology1.03330300
66MP0001881_abnormal_mammary_gland1.02589160
67MP0000538_abnormal_urinary_bladder1.02271802
68MP0003119_abnormal_digestive_system1.01895119
69MP0004043_abnormal_pH_regulation1.01466240
70MP0003984_embryonic_growth_retardation1.01196771
71MP0004019_abnormal_vitamin_homeostasis0.99738420
72MP0002088_abnormal_embryonic_growth/wei0.98982898
73MP0009931_abnormal_skin_appearance0.98572217
74MP0002697_abnormal_eye_size0.98524295
75MP0008789_abnormal_olfactory_epithelium0.98227552
76MP0000470_abnormal_stomach_morphology0.98072801
77MP0001697_abnormal_embryo_size0.97723553
78MP0005248_abnormal_Harderian_gland0.97303509
79MP0008004_abnormal_stomach_pH0.96906262
80MP0003718_maternal_effect0.93943023
81MP0004782_abnormal_surfactant_physiolog0.93705349
82MP0006054_spinal_hemorrhage0.93656793
83MP0010386_abnormal_urinary_bladder0.93069626
84MP0002909_abnormal_adrenal_gland0.92403955
85MP0009703_decreased_birth_body0.92297114
86MP0002896_abnormal_bone_mineralization0.91927465
87MP0009053_abnormal_anal_canal0.91365314
88MP0005409_darkened_coat_color0.90988065
89MP0004197_abnormal_fetal_growth/weight/0.90521464
90MP0001191_abnormal_skin_condition0.90056740
91MP0001293_anophthalmia0.89724696
92MP0002086_abnormal_extraembryonic_tissu0.89539414
93MP0005408_hypopigmentation0.89095561
94MP0002277_abnormal_respiratory_mucosa0.87939181
95MP0005310_abnormal_salivary_gland0.87342907
96MP0000367_abnormal_coat/_hair0.87017368
97MP0003699_abnormal_female_reproductive0.85811431
98MP0002080_prenatal_lethality0.84029792
99MP0003937_abnormal_limbs/digits/tail_de0.83987154
100MP0000003_abnormal_adipose_tissue0.83113202
101MP0005451_abnormal_body_composition0.80590996
102MP0002233_abnormal_nose_morphology0.80204568
103MP0002084_abnormal_developmental_patter0.78343933
104MP0003755_abnormal_palate_morphology0.75776788
105MP0003866_abnormal_defecation0.74866278
106MP0003123_paternal_imprinting0.74314364
107MP0000477_abnormal_intestine_morphology0.74184738
108MP0001243_abnormal_dermal_layer0.71415335
109MP0002111_abnormal_tail_morphology0.71161453
110MP0000432_abnormal_head_morphology0.71006978
111MP0003878_abnormal_ear_physiology0.69639936
112MP0005377_hearing/vestibular/ear_phenot0.69639936
113MP0001340_abnormal_eyelid_morphology0.67955880
114MP0009379_abnormal_foot_pigmentation0.66853787
115MP0006072_abnormal_retinal_apoptosis0.66233145
116MP0002653_abnormal_ependyma_morphology0.66107359
117MP0005379_endocrine/exocrine_gland_phen0.65812460
118MP0004233_abnormal_muscle_weight0.65258657
119MP0008877_abnormal_DNA_methylation0.64022274
120MP0002085_abnormal_embryonic_tissue0.63977530
121MP0003936_abnormal_reproductive_system0.63202225
122MP0001730_embryonic_growth_arrest0.63165169
123MP0001929_abnormal_gametogenesis0.63164245
124MP0001286_abnormal_eye_development0.63094797
125MP0002210_abnormal_sex_determination0.62860312
126MP0005023_abnormal_wound_healing0.62821915
127MP0001765_abnormal_ion_homeostasis0.62549493
128MP0000490_abnormal_crypts_of0.62364941
129MP0001485_abnormal_pinna_reflex0.61911738
130MP0009672_abnormal_birth_weight0.61816354
131MP0002177_abnormal_outer_ear0.61459518
132MP0008007_abnormal_cellular_replicative0.58989035
133MP0003567_abnormal_fetal_cardiomyocyte0.58557360
134MP0005394_taste/olfaction_phenotype0.58133751
135MP0005499_abnormal_olfactory_system0.58133751
136MP0003183_abnormal_peptide_metabolism0.56573234
137MP0002160_abnormal_reproductive_system0.56343506
138MP0001919_abnormal_reproductive_system0.55807307

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.89133433
2Onycholysis (HP:0001806)5.72702599
3Pili torti (HP:0003777)5.51616909
4Milia (HP:0001056)5.44978812
5Fragile nails (HP:0001808)5.23365375
6Woolly hair (HP:0002224)5.13386590
7Lip pit (HP:0100267)4.97829274
8Plantar hyperkeratosis (HP:0007556)4.97231603
9Hypotrichosis (HP:0001006)4.16437906
10Palmoplantar hyperkeratosis (HP:0000972)3.77870756
11Abnormality of nail color (HP:0100643)3.74102922
12Atrophic scars (HP:0001075)3.66574566
13Palmar hyperkeratosis (HP:0010765)3.61628316
14Curly hair (HP:0002212)3.60744070
15Hypoplastic labia majora (HP:0000059)3.42102868
16Nail dystrophy (HP:0008404)3.34708913
17Abnormal hair laboratory examination (HP:0003328)3.24651251
18Selective tooth agenesis (HP:0001592)3.13711327
19Rectal prolapse (HP:0002035)3.10086941
20Abnormality of the labia majora (HP:0012881)3.09640032
21Increased IgE level (HP:0003212)3.09101183
22Abnormal biliary tract morphology (HP:0012440)3.01443780
23Hypoplasia of dental enamel (HP:0006297)2.96770223
24Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.96710518
25Abnormal blistering of the skin (HP:0008066)2.95619925
26Congenital ichthyosiform erythroderma (HP:0007431)2.95389304
27Abnormality of the gastric mucosa (HP:0004295)2.89969263
28Chromsome breakage (HP:0040012)2.87824079
29Biliary tract neoplasm (HP:0100574)2.87013163
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83758924
31Hyperglycemia (HP:0003074)2.80236090
32Abnormality of small intestinal villus morphology (HP:0011472)2.71014597
33Villous atrophy (HP:0011473)2.71014597
34Male infertility (HP:0003251)2.69359640
35Abnormal pancreas size (HP:0012094)2.66993915
36Septate vagina (HP:0001153)2.63456035
37Unilateral renal agenesis (HP:0000122)2.58275817
38Breast carcinoma (HP:0003002)2.56064306
39Insulin-resistant diabetes mellitus (HP:0000831)2.54946732
40Natal tooth (HP:0000695)2.54043651
41Ventricular fibrillation (HP:0001663)2.52959849
42Abnormality of chloride homeostasis (HP:0011422)2.51697926
43Sparse scalp hair (HP:0002209)2.47516806
44Nephroblastoma (Wilms tumor) (HP:0002667)2.46248018
45Blepharitis (HP:0000498)2.45429718
46Popliteal pterygium (HP:0009756)2.44293190
47Multiple enchondromatosis (HP:0005701)2.41491595
48Ridged nail (HP:0001807)2.40591448
49Intrahepatic cholestasis (HP:0001406)2.40252630
50Absent hair (HP:0002298)2.40227573
51Aplasia cutis congenita (HP:0001057)2.37325153
52Chronic bronchitis (HP:0004469)2.32877409
53Abnormality of the dental root (HP:0006486)2.32559086
54Taurodontia (HP:0000679)2.32559086
55Abnormality of permanent molar morphology (HP:0011071)2.32559086
56Abnormality of the preputium (HP:0100587)2.32441944
57Abnormality of the labia minora (HP:0012880)2.30213684
58Amelogenesis imperfecta (HP:0000705)2.29379117
59Aplasia/hypoplasia of the uterus (HP:0008684)2.28421957
60Absent eyebrow (HP:0002223)2.27650733
61Hyperactive renin-angiotensin system (HP:0000841)2.24875332
62Abnormality of secondary sexual hair (HP:0009888)2.24262170
63Abnormality of the axillary hair (HP:0100134)2.24262170
64Symptomatic seizures (HP:0011145)2.23648422
65Embryonal renal neoplasm (HP:0011794)2.23606324
66Sparse eyelashes (HP:0000653)2.23542881
67Oral leukoplakia (HP:0002745)2.21849644
68Abnormality of the salivary glands (HP:0010286)2.21709815
69Depressed nasal tip (HP:0000437)2.17625101
70Abnormality of the distal phalanges of the toes (HP:0010182)2.15729083
71Advanced eruption of teeth (HP:0006288)2.15007125
72Hyperinsulinemic hypoglycemia (HP:0000825)2.14813819
73Abnormal hemoglobin (HP:0011902)2.13635907
74Exocrine pancreatic insufficiency (HP:0001738)2.09093674
75Abnormality of the dental pulp (HP:0006479)2.07442958
76Hypoplasia of the uterus (HP:0000013)2.06276435
77Abnormality of molar morphology (HP:0011070)2.05808661
78Abnormality of molar (HP:0011077)2.05808661
79Dehydration (HP:0001944)2.05281466
80Ectropion (HP:0000656)2.04228086
81Abnormality of the lacrimal duct (HP:0011481)2.02547857
82Ileus (HP:0002595)2.01407739
83Pterygium (HP:0001059)2.00591809
84Colon cancer (HP:0003003)1.99469737
85Hypohidrosis (HP:0000966)1.98631905
86Alopecia of scalp (HP:0002293)1.98448378
87Abnormality of calcium-phosphate metabolism (HP:0100530)1.96473951
88Abnormality of the labia (HP:0000058)1.95404539
89Trismus (HP:0000211)1.92825785
90Esophageal atresia (HP:0002032)1.91070158
91Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.91031903
92Absent radius (HP:0003974)1.88857991
93Stenosis of the external auditory canal (HP:0000402)1.88697694
94Flat acetabular roof (HP:0003180)1.88448055
95Abdominal distention (HP:0003270)1.87604957
96Rhabdomyosarcoma (HP:0002859)1.86994650
97Corneal erosion (HP:0200020)1.85027627
98Hyperparathyroidism (HP:0000843)1.84240387
99Thick nail (HP:0001805)1.83519050
100Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.83203112
101Ependymoma (HP:0002888)1.83010971
102Skin pits (HP:0100276)1.82954962
103Anonychia (HP:0001798)1.81754105
104Ankyloglossia (HP:0010296)1.79563946
105Hypoglycemic seizures (HP:0002173)1.79240185
106Abnormality of cochlea (HP:0000375)1.78012911
107Hyperphosphatemia (HP:0002905)1.77575648
108Uterine neoplasm (HP:0010784)1.76953318
109Labial hypoplasia (HP:0000066)1.76080570
110Papillary thyroid carcinoma (HP:0002895)1.75894434
111Aplasia involving forearm bones (HP:0009822)1.75719280
112Absent forearm bone (HP:0003953)1.75719280
113Ventricular tachycardia (HP:0004756)1.74938827
114Gastrointestinal carcinoma (HP:0002672)1.74360555
115Malignant gastrointestinal tract tumors (HP:0006749)1.74360555
116Fragile skin (HP:0001030)1.74356712
117Facial cleft (HP:0002006)1.74142130
118Abdominal situs inversus (HP:0003363)1.73539068
119Abnormality of abdominal situs (HP:0011620)1.73539068
120Gonadotropin excess (HP:0000837)1.73524396
121Shawl scrotum (HP:0000049)1.73211064
122Malnutrition (HP:0004395)1.73087684
123Dry hair (HP:0011359)1.72351266
124Absent eyelashes (HP:0000561)1.72335434
125Conjunctival hamartoma (HP:0100780)1.71769351
126Germ cell neoplasia (HP:0100728)1.71129845
127Erythema (HP:0010783)1.68762359
128Abnormality of the nasolacrimal system (HP:0000614)1.68702443
129Micronodular cirrhosis (HP:0001413)1.68092482
130Hypokalemia (HP:0002900)1.67708831
131Fatigable weakness (HP:0003473)1.67143385
132Abnormality of the neuromuscular junction (HP:0003398)1.67143385
133Erythroderma (HP:0001019)1.67098585
134Palmoplantar keratoderma (HP:0000982)1.66199567
135Oligodontia (HP:0000677)1.64918326
136Median cleft lip (HP:0000161)1.64837844
137Non-midline cleft lip (HP:0100335)1.64626531
138Hypoplastic female external genitalia (HP:0012815)1.64334775
139Choanal atresia (HP:0000453)1.63948046
140Abnormal lung lobation (HP:0002101)1.62976378
141Bronchomalacia (HP:0002780)1.62512932
142Hypodontia (HP:0000668)1.61912751
143Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.61710936
144Abnormality of monocarboxylic acid metabolism (HP:0010996)1.61422853
145Bifid scrotum (HP:0000048)1.61047067
146Choanal stenosis (HP:0000452)1.60171401
147Ovarian neoplasm (HP:0100615)1.58879893
148Anal stenosis (HP:0002025)1.58785789
149Azoospermia (HP:0000027)1.57563948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.69621307
2EPHA24.43340530
3FRK3.37605898
4MAP3K23.10429384
5PBK2.69053719
6MST1R2.68684305
7TSSK62.68157815
8TAOK32.60403038
9MAPKAPK32.50000363
10STK38L2.46362286
11MST42.41726863
12LMTK22.38610243
13MAP3K92.35717833
14PASK2.32015191
15FER2.28768626
16MAP3K32.19973882
17RPS6KB22.05037036
18EEF2K1.96303426
19INSRR1.87149084
20BUB11.84662154
21TRIM281.81512337
22MET1.78015651
23ERN11.69910784
24MAP2K21.66098015
25SMG11.58496148
26CDK121.57500967
27TAF11.56535206
28TNIK1.55030314
29PTK61.55007035
30EIF2AK31.50922312
31NEK61.49455876
32RIPK11.49202291
33MAPK151.47553454
34STK31.46847790
35TTK1.44320113
36AKT31.43509497
37SRPK11.42709117
38NUAK11.40045626
39EPHA31.39722909
40PTK21.33461904
41VRK21.33228176
42HIPK21.28916005
43PLK31.25472837
44PRKCI1.21169129
45LATS21.18430863
46EIF2AK11.16547111
47MAP3K121.15248300
48WEE11.12953124
49MAP3K11.11818293
50CDK71.11626696
51TRIB31.08071366
52WNK41.07822888
53PRKD31.05654707
54TGFBR11.05463183
55SIK11.04645139
56RPS6KA41.03042297
57MKNK21.02312445
58NLK1.00181155
59OXSR11.00119212
60CAMK1D0.99905536
61AURKB0.99717059
62BCR0.96136222
63NME10.95570023
64SCYL20.95327760
65STK100.94802214
66BRSK20.94125994
67TESK10.93432657
68EPHB20.93101779
69ERBB40.90429667
70ZAK0.88143159
71TAOK10.87065449
72LRRK20.86297818
73CAMK1G0.85865221
74NEK10.85535024
75TRPM70.84365310
76CDK60.83257484
77PDGFRA0.80307260
78DYRK1B0.80097680
79BRSK10.79028299
80PIK3CA0.78347011
81MTOR0.73057154
82CDC42BPA0.71040781
83MKNK10.70843562
84PNCK0.70619830
85MELK0.70315961
86DYRK30.70031354
87STK240.69933981
88IRAK30.69432895
89ACVR1B0.67858892
90ERBB20.66765270
91PIK3CG0.65780740
92EIF2AK20.62711271
93MAP3K80.58700109
94CDK90.56943195
95NEK20.56161237
96PKN20.56123294
97CHUK0.55931879
98EPHB10.55522122
99MAP3K60.55021054
100MAP2K10.54831593
101ARAF0.54338352
102STK390.51947076
103KSR20.50841887
104ERBB30.50592775
105ATR0.49513633
106PLK40.48986465
107ALK0.48163138
108FLT30.48095726
109FGFR10.48095693
110BRD40.47414421
111DMPK0.47405272
112CDC70.46987705
113PRKG20.46906719
114NME20.43539524
115BRAF0.43336626
116BMX0.43297730
117AURKA0.40711615
118CSNK1E0.39939405
119MAPKAPK20.39677362
120RET0.39270841
121RPS6KB10.38885190
122ATM0.38169162
123PDGFRB0.38105593
124PRKAA10.36860828
125CDK10.36429723
126CDK20.36326194
127RPS6KA10.35816140
128FGFR30.35246362
129YES10.35224477
130PLK10.34914123
131AKT20.33843737
132SIK30.33124185
133CHEK20.31801202
134FGFR40.31572487
135CHEK10.31332808
136MAP3K100.30991868
137CDK30.30220974
138PAK40.29524755
139MAP2K60.27394458
140FGFR20.26883736

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.20907617
2Sulfur metabolism_Homo sapiens_hsa009203.04499208
3Protein export_Homo sapiens_hsa030602.90371090
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.73363312
5Mismatch repair_Homo sapiens_hsa034302.44706191
6Adherens junction_Homo sapiens_hsa045202.27836439
7Linoleic acid metabolism_Homo sapiens_hsa005912.23240884
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22626027
9Non-homologous end-joining_Homo sapiens_hsa034502.08508397
10DNA replication_Homo sapiens_hsa030301.97770527
11Tight junction_Homo sapiens_hsa045301.93960424
12Cysteine and methionine metabolism_Homo sapiens_hsa002701.92270707
13Pancreatic secretion_Homo sapiens_hsa049721.92135643
14Vitamin B6 metabolism_Homo sapiens_hsa007501.88249040
15Thyroid cancer_Homo sapiens_hsa052161.87916376
16Hippo signaling pathway_Homo sapiens_hsa043901.83936114
17Fat digestion and absorption_Homo sapiens_hsa049751.81148858
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79338576
19Vitamin digestion and absorption_Homo sapiens_hsa049771.78067796
20Basal cell carcinoma_Homo sapiens_hsa052171.70757199
21Proteasome_Homo sapiens_hsa030501.68795973
22Bladder cancer_Homo sapiens_hsa052191.68741333
23Protein digestion and absorption_Homo sapiens_hsa049741.63324148
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.62619814
25Mineral absorption_Homo sapiens_hsa049781.60888215
26Base excision repair_Homo sapiens_hsa034101.47271481
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.47021656
28Vibrio cholerae infection_Homo sapiens_hsa051101.46390083
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41971319
30Sphingolipid metabolism_Homo sapiens_hsa006001.38705050
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35852326
32Endometrial cancer_Homo sapiens_hsa052131.31964976
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31137807
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27949933
35Selenocompound metabolism_Homo sapiens_hsa004501.25584137
36Caffeine metabolism_Homo sapiens_hsa002321.24181630
37Folate biosynthesis_Homo sapiens_hsa007901.22328900
38Prolactin signaling pathway_Homo sapiens_hsa049171.22092293
39Homologous recombination_Homo sapiens_hsa034401.19692445
40Nucleotide excision repair_Homo sapiens_hsa034201.18413745
41TGF-beta signaling pathway_Homo sapiens_hsa043501.17742409
42p53 signaling pathway_Homo sapiens_hsa041151.16918145
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15853827
44Arachidonic acid metabolism_Homo sapiens_hsa005901.15820940
45Oocyte meiosis_Homo sapiens_hsa041141.15817743
46Fatty acid elongation_Homo sapiens_hsa000621.15304957
47Pyruvate metabolism_Homo sapiens_hsa006201.15224404
48One carbon pool by folate_Homo sapiens_hsa006701.14849495
49Spliceosome_Homo sapiens_hsa030401.13605990
50Steroid biosynthesis_Homo sapiens_hsa001001.12738348
51Hedgehog signaling pathway_Homo sapiens_hsa043401.10618634
52Prostate cancer_Homo sapiens_hsa052151.08897574
53Histidine metabolism_Homo sapiens_hsa003401.04074113
54Small cell lung cancer_Homo sapiens_hsa052221.03680424
55MicroRNAs in cancer_Homo sapiens_hsa052061.03386270
56Arginine and proline metabolism_Homo sapiens_hsa003301.03029273
57Ribosome_Homo sapiens_hsa030101.02758716
58RNA polymerase_Homo sapiens_hsa030201.02482371
59Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01789507
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01408951
61Propanoate metabolism_Homo sapiens_hsa006401.01270461
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00998881
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00731710
64Ether lipid metabolism_Homo sapiens_hsa005651.00698817
65ECM-receptor interaction_Homo sapiens_hsa045121.00313049
66N-Glycan biosynthesis_Homo sapiens_hsa005100.99571643
67Insulin secretion_Homo sapiens_hsa049110.98350641
68Dorso-ventral axis formation_Homo sapiens_hsa043200.98275927
69Arginine biosynthesis_Homo sapiens_hsa002200.97582924
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96216495
71Biosynthesis of amino acids_Homo sapiens_hsa012300.95137693
72Circadian rhythm_Homo sapiens_hsa047100.94511813
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94189083
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93434625
75Insulin resistance_Homo sapiens_hsa049310.92942558
76RNA transport_Homo sapiens_hsa030130.92740249
77Cell cycle_Homo sapiens_hsa041100.90757586
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90641300
79Fanconi anemia pathway_Homo sapiens_hsa034600.90118341
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87427260
81Notch signaling pathway_Homo sapiens_hsa043300.86391429
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84598669
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82674465
84Proteoglycans in cancer_Homo sapiens_hsa052050.82585368
85Thyroid hormone synthesis_Homo sapiens_hsa049180.81282081
86Basal transcription factors_Homo sapiens_hsa030220.80559951
87Type II diabetes mellitus_Homo sapiens_hsa049300.78600977
88Pancreatic cancer_Homo sapiens_hsa052120.78541320
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76498341
90Carbon metabolism_Homo sapiens_hsa012000.74492696
91mTOR signaling pathway_Homo sapiens_hsa041500.73960975
92Wnt signaling pathway_Homo sapiens_hsa043100.73525913
93Retinol metabolism_Homo sapiens_hsa008300.70796355
94Melanogenesis_Homo sapiens_hsa049160.70323319
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.70119629
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69254354
97Hepatitis C_Homo sapiens_hsa051600.68145084
98Amoebiasis_Homo sapiens_hsa051460.66182765
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.65609640
100RNA degradation_Homo sapiens_hsa030180.65406287
101beta-Alanine metabolism_Homo sapiens_hsa004100.64168939
102FoxO signaling pathway_Homo sapiens_hsa040680.58403407
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58398912
104Renin-angiotensin system_Homo sapiens_hsa046140.58318143
105mRNA surveillance pathway_Homo sapiens_hsa030150.58303210
106Glutathione metabolism_Homo sapiens_hsa004800.58099889
107Pathways in cancer_Homo sapiens_hsa052000.57939879
108Toxoplasmosis_Homo sapiens_hsa051450.56010559
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55789527
110Starch and sucrose metabolism_Homo sapiens_hsa005000.55544951
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54501151
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53625992
113Estrogen signaling pathway_Homo sapiens_hsa049150.53427061
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.52753010
115Pyrimidine metabolism_Homo sapiens_hsa002400.52234417
116Melanoma_Homo sapiens_hsa052180.51300910
117Focal adhesion_Homo sapiens_hsa045100.50928961
118Chronic myeloid leukemia_Homo sapiens_hsa052200.49392311
119VEGF signaling pathway_Homo sapiens_hsa043700.49216317
120Ovarian steroidogenesis_Homo sapiens_hsa049130.49071008
121HTLV-I infection_Homo sapiens_hsa051660.48934713
122Galactose metabolism_Homo sapiens_hsa000520.48934358
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47821180
124Other glycan degradation_Homo sapiens_hsa005110.47463237
125Renal cell carcinoma_Homo sapiens_hsa052110.47295796
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46806019
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45953765
128Tyrosine metabolism_Homo sapiens_hsa003500.45534874
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45032183
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44926844
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44546275
132AMPK signaling pathway_Homo sapiens_hsa041520.44423189
133Pentose phosphate pathway_Homo sapiens_hsa000300.43441658
134ABC transporters_Homo sapiens_hsa020100.43224523
135Antigen processing and presentation_Homo sapiens_hsa046120.41011953
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40839860
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39713988
138Lysosome_Homo sapiens_hsa041420.39538781
139Lysine degradation_Homo sapiens_hsa003100.39295425
140Colorectal cancer_Homo sapiens_hsa052100.38632956
141GnRH signaling pathway_Homo sapiens_hsa049120.38355062
142Inositol phosphate metabolism_Homo sapiens_hsa005620.37822240
143Viral carcinogenesis_Homo sapiens_hsa052030.37348888
144Phenylalanine metabolism_Homo sapiens_hsa003600.37229715
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37081367
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.35617416

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