ESRP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.80729170
2L-phenylalanine catabolic process (GO:0006559)6.99370359
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.99370359
4L-phenylalanine metabolic process (GO:0006558)6.75602841
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.75602841
6aromatic amino acid family catabolic process (GO:0009074)6.26984640
7bundle of His cell to Purkinje myocyte communication (GO:0086069)5.85520147
8indole-containing compound catabolic process (GO:0042436)5.73816659
9indolalkylamine catabolic process (GO:0046218)5.73816659
10tryptophan catabolic process (GO:0006569)5.73816659
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.67398464
12regulation of water loss via skin (GO:0033561)5.65844091
13kynurenine metabolic process (GO:0070189)5.61735868
14cysteine metabolic process (GO:0006534)5.57323894
15sulfur amino acid catabolic process (GO:0000098)5.43598185
16glyoxylate metabolic process (GO:0046487)5.41491262
17tryptophan metabolic process (GO:0006568)5.40843997
18bile acid biosynthetic process (GO:0006699)5.36763475
19serine family amino acid catabolic process (GO:0009071)5.28458334
20urea cycle (GO:0000050)5.23764734
21urea metabolic process (GO:0019627)5.23764734
22intestinal epithelial cell development (GO:0060576)5.08769093
23establishment of skin barrier (GO:0061436)5.04998717
24negative regulation of fibrinolysis (GO:0051918)5.03024832
25high-density lipoprotein particle remodeling (GO:0034375)4.98356583
26protein carboxylation (GO:0018214)4.95552659
27peptidyl-glutamic acid carboxylation (GO:0017187)4.95552659
28alpha-linolenic acid metabolic process (GO:0036109)4.90900006
29regulation of fibrinolysis (GO:0051917)4.88765577
30regulation of protein activation cascade (GO:2000257)4.87703722
31homocysteine metabolic process (GO:0050667)4.84330097
32nitrogen cycle metabolic process (GO:0071941)4.80114881
33amino-acid betaine metabolic process (GO:0006577)4.75021773
34complement activation, alternative pathway (GO:0006957)4.72689225
35aromatic amino acid family metabolic process (GO:0009072)4.70051045
36glycine metabolic process (GO:0006544)4.69227692
37bile acid metabolic process (GO:0008206)4.65180110
38regulation of triglyceride catabolic process (GO:0010896)4.56592720
39regulation of complement activation (GO:0030449)4.55450895
40multicellular organismal water homeostasis (GO:0050891)4.48047070
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.45545492
42negative regulation of cholesterol transport (GO:0032375)4.45113971
43negative regulation of sterol transport (GO:0032372)4.45113971
44serine family amino acid metabolic process (GO:0009069)4.40785637
45regulation of cholesterol esterification (GO:0010872)4.36932898
46alpha-amino acid catabolic process (GO:1901606)4.35173951
47lysine catabolic process (GO:0006554)4.33195877
48lysine metabolic process (GO:0006553)4.33195877
49reverse cholesterol transport (GO:0043691)4.31938337
50phospholipid efflux (GO:0033700)4.29992738
51triglyceride homeostasis (GO:0070328)4.29947840
52acylglycerol homeostasis (GO:0055090)4.29947840
53tyrosine metabolic process (GO:0006570)4.25316519
54plasma lipoprotein particle remodeling (GO:0034369)4.21306649
55protein-lipid complex remodeling (GO:0034368)4.21306649
56macromolecular complex remodeling (GO:0034367)4.21306649
57serine family amino acid biosynthetic process (GO:0009070)4.18061673
58bile acid and bile salt transport (GO:0015721)4.18003020
59hemidesmosome assembly (GO:0031581)4.15082508
60regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.13184869
61imidazole-containing compound metabolic process (GO:0052803)4.11832622
62positive regulation of keratinocyte differentiation (GO:0045618)4.10663080
63cellular amino acid catabolic process (GO:0009063)4.06486884
64proline biosynthetic process (GO:0006561)4.03931409
65indolalkylamine metabolic process (GO:0006586)4.02081974
66regulation of cholesterol homeostasis (GO:2000188)3.99554376
67cellular glucuronidation (GO:0052695)3.98945312
68cellular modified amino acid catabolic process (GO:0042219)3.98113779
69fibrinolysis (GO:0042730)3.96017550
70cellular ketone body metabolic process (GO:0046950)3.95922188
71cellular biogenic amine catabolic process (GO:0042402)3.95807888
72amine catabolic process (GO:0009310)3.95807888
73biotin metabolic process (GO:0006768)3.95520441
74gap junction assembly (GO:0016264)3.91722009
75positive regulation of epidermal cell differentiation (GO:0045606)3.90626460
76plasma lipoprotein particle clearance (GO:0034381)3.89109228
77ethanol oxidation (GO:0006069)3.89045147
78glutamate metabolic process (GO:0006536)3.86792140
79proline metabolic process (GO:0006560)3.85467446
80benzene-containing compound metabolic process (GO:0042537)3.85093551
81coenzyme catabolic process (GO:0009109)3.81958860
82intestinal cholesterol absorption (GO:0030299)3.79320837
83drug catabolic process (GO:0042737)3.78496906
84positive regulation of lipoprotein lipase activity (GO:0051006)3.77068057
85positive regulation of triglyceride lipase activity (GO:0061365)3.77068057
86regulation of bile acid biosynthetic process (GO:0070857)3.75349410
87cholesterol efflux (GO:0033344)3.74346254
88cholesterol homeostasis (GO:0042632)3.68475338
89water homeostasis (GO:0030104)3.67799790
90sterol homeostasis (GO:0055092)3.63227131
91arginine metabolic process (GO:0006525)3.62997617
92negative regulation of lipase activity (GO:0060192)3.61655792
93establishment of apical/basal cell polarity (GO:0035089)3.59611672
94carboxylic acid catabolic process (GO:0046395)3.58489336
95organic acid catabolic process (GO:0016054)3.58489336
96epithelial cell-cell adhesion (GO:0090136)3.58433162
97plasma lipoprotein particle assembly (GO:0034377)3.58099101
98urate metabolic process (GO:0046415)3.57685265
99branching involved in mammary gland duct morphogenesis (GO:0060444)3.56645714
100uronic acid metabolic process (GO:0006063)3.54325303
101glucuronate metabolic process (GO:0019585)3.54325303
102COPI coating of Golgi vesicle (GO:0048205)3.51493869
103Golgi transport vesicle coating (GO:0048200)3.51493869
104short-chain fatty acid metabolic process (GO:0046459)3.49745601
105carnitine metabolic process (GO:0009437)3.47816307
106blood coagulation, intrinsic pathway (GO:0007597)3.46161326
107positive regulation of lipid catabolic process (GO:0050996)3.43926859
108phospholipid homeostasis (GO:0055091)3.40901480
109ketone body metabolic process (GO:1902224)3.40548679
110aldehyde catabolic process (GO:0046185)3.38156082
111very-low-density lipoprotein particle assembly (GO:0034379)3.38083903
112complement activation, classical pathway (GO:0006958)3.37809243
113acetyl-CoA metabolic process (GO:0006084)3.36804590
114complement activation (GO:0006956)3.36695510
115response to nitrosative stress (GO:0051409)3.35637569
116ethanol metabolic process (GO:0006067)3.34449890
117protein activation cascade (GO:0072376)3.33449071
118low-density lipoprotein particle remodeling (GO:0034374)3.33027171
119regulation of cholesterol biosynthetic process (GO:0045540)3.33010162
120fatty acid oxidation (GO:0019395)3.30643991
121drug transmembrane transport (GO:0006855)3.30305594
122ear development (GO:0043583)3.30083334
123positive regulation of Cdc42 GTPase activity (GO:0043089)3.27419327
124maternal placenta development (GO:0001893)3.26198902
125negative regulation of keratinocyte proliferation (GO:0010839)3.24816152
126epoxygenase P450 pathway (GO:0019373)3.24193554
127epithelial cell differentiation involved in prostate gland development (GO:0060742)3.20626659
128surfactant homeostasis (GO:0043129)3.20055524
129regulation of keratinocyte differentiation (GO:0045616)3.20051230
130L-alpha-amino acid transmembrane transport (GO:1902475)3.10691106
131polarized epithelial cell differentiation (GO:0030859)3.10240497
132keratinization (GO:0031424)3.07647223
133tight junction assembly (GO:0070830)3.04029846
134chemical homeostasis within a tissue (GO:0048875)3.03775626
135response to food (GO:0032094)3.02710922
136epithelial cell maturation (GO:0002070)3.02267377
137regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.01919180
138regulation of fatty acid beta-oxidation (GO:0031998)3.01037751
139positive regulation of epidermis development (GO:0045684)2.97625361
140primary alcohol catabolic process (GO:0034310)2.92482287
141calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.86918022
142planar cell polarity pathway involved in neural tube closure (GO:0090179)2.86844403
143trivalent inorganic anion homeostasis (GO:0072506)2.81928451
144phosphate ion homeostasis (GO:0055062)2.81928451
145branching involved in salivary gland morphogenesis (GO:0060445)2.81751334
146regulation of cell proliferation involved in kidney development (GO:1901722)2.80819744
147regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.79427358
148keratinocyte development (GO:0003334)2.77500355
149cardiac right ventricle morphogenesis (GO:0003215)2.74818241
150positive regulation of hormone metabolic process (GO:0032352)2.74737964
151positive regulation of cellular amine metabolic process (GO:0033240)2.73590559
152semaphorin-plexin signaling pathway (GO:0071526)2.72836732
153GDP-mannose metabolic process (GO:0019673)2.71530131
154establishment of monopolar cell polarity (GO:0061162)2.70374597
155establishment or maintenance of monopolar cell polarity (GO:0061339)2.70374597
156trophectodermal cell differentiation (GO:0001829)2.69824469
157lung epithelium development (GO:0060428)2.69434618
158omega-hydroxylase P450 pathway (GO:0097267)2.65934904
159atrioventricular valve morphogenesis (GO:0003181)2.64587138
160negative regulation of cell size (GO:0045792)2.64540717
161activation of Rac GTPase activity (GO:0032863)2.62907827
162negative regulation of cell fate specification (GO:0009996)2.62890648
163negative regulation of cell fate commitment (GO:0010454)2.61941779
164regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.60735905
165regulation of cholesterol metabolic process (GO:0090181)2.58529863
166mammary gland epithelial cell differentiation (GO:0060644)2.57297374
167retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.56634772
168glutamine family amino acid biosynthetic process (GO:0009084)2.54976152
169dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.54018762
170keratinocyte proliferation (GO:0043616)2.52284415
171insulin-like growth factor receptor signaling pathway (GO:0048009)2.51056196
172cell-cell junction assembly (GO:0007043)2.48925470
173embryonic eye morphogenesis (GO:0048048)2.48242840
174regulation of hippo signaling (GO:0035330)2.48230541
175ectoderm development (GO:0007398)2.48180662
176flavonoid metabolic process (GO:0009812)2.47549891
177cell-substrate junction assembly (GO:0007044)2.46239125
178focal adhesion assembly (GO:0048041)2.45624493
179cell-substrate adherens junction assembly (GO:0007045)2.45624493
180L-serine metabolic process (GO:0006563)2.45212469
181nucleotide-sugar biosynthetic process (GO:0009226)2.45120276
182cell differentiation involved in embryonic placenta development (GO:0060706)2.44924809
183columnar/cuboidal epithelial cell development (GO:0002066)2.44511878
184exogenous drug catabolic process (GO:0042738)2.44008306
185adherens junction assembly (GO:0034333)2.43681587
1864-hydroxyproline metabolic process (GO:0019471)2.43292574

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.35433385
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.59286360
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.92468841
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.67394133
5TP63_17297297_ChIP-ChIP_HaCaT_Human5.11825881
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.71300861
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.55351738
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.53237455
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.52904049
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.40733932
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.36169487
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.88865744
13* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.59861890
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.30294375
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.08262689
16ZNF263_19887448_ChIP-Seq_K562_Human2.07051044
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4660150
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97683591
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95102913
20* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.92006746
21CLOCK_20551151_ChIP-Seq_293T_Human1.77062504
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.64488001
23GATA1_22025678_ChIP-Seq_K562_Human1.61682456
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59412330
25* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56264308
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.52566217
27E2F7_22180533_ChIP-Seq_HELA_Human1.50106130
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.49518936
29* GATA4_25053715_ChIP-Seq_YYC3_Human1.48285860
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47887182
31CHD1_26751641_Chip-Seq_LNCaP_Human1.46833215
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40909274
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36694060
34KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34249753
35SMC4_20622854_ChIP-Seq_HELA_Human1.32761218
36* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31712040
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.31000575
38KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30309168
39AHR_22903824_ChIP-Seq_MCF-7_Human1.29845625
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.28027458
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26005719
42HNF4A_19822575_ChIP-Seq_HepG2_Human1.25989913
43* KLF5_25053715_ChIP-Seq_YYC3_Human1.23930895
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23457288
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.22555808
46P68_20966046_ChIP-Seq_HELA_Human1.22281027
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21901433
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21261184
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20929163
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14702951
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14458775
52* GATA6_25053715_ChIP-Seq_YYC3_Human1.14420738
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.14046286
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12156325
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12142255
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11467412
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.10960397
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09910260
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09369056
60* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07512626
61TCF7_22412390_ChIP-Seq_EML_Mouse1.06766144
62* KDM5A_27292631_Chip-Seq_BREAST_Human1.06687123
63HTT_18923047_ChIP-ChIP_STHdh_Human1.06532391
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05937623
65ELF5_23300383_ChIP-Seq_T47D_Human1.05393553
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03039770
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.02557311
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.02010218
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01381641
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01359148
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00081558
72BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99034890
73MYC_22102868_ChIP-Seq_BL_Human0.98686147
74KDM2B_26808549_Chip-Seq_K562_Human0.97251316
75RACK7_27058665_Chip-Seq_MCF-7_Human0.97010180
76EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95911564
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95801233
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95120818
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94838047
80ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92993304
81XRN2_22483619_ChIP-Seq_HELA_Human0.92300724
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91686802
83MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91382270
84CTCF_27219007_Chip-Seq_Bcells_Human0.90226301
85* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89569817
86SOX2_20726797_ChIP-Seq_SW620_Human0.89555411
87SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88515553
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88340514
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88213079
90KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86461258
91PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85695410
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84209238
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82558565
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82061530
95GATA3_24758297_ChIP-Seq_MCF-7_Human0.81508866
96SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81499908
97* ATF3_27146783_Chip-Seq_COLON_Human0.80077927
98* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80052828
99* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79991329
100AR_21909140_ChIP-Seq_LNCAP_Human0.78901911
101* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77331284
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76234436
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76109051
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.75678045
105CEBPB_22108803_ChIP-Seq_LS180_Human0.75529621
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75184183
107LXR_22292898_ChIP-Seq_THP-1_Human0.74391348
108RARA_24833708_ChIP-Seq_LIVER_Mouse0.73655905
109TRIM28_21343339_ChIP-Seq_HEK293_Human0.73619841
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.70712942
111RARB_24833708_ChIP-Seq_LIVER_Mouse0.69799586
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.69735638
113* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.66349703
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.64964053
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.64229588
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.64229588
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.63336035
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62920986
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.62039775
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60096329
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.58307425
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.57928497
123* FOXA1_25552417_ChIP-Seq_VCAP_Human0.57884328
124TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.57794655
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.57059831
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56825685
127TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.56489482
128* RUNX1_27514584_Chip-Seq_MCF-7_Human0.55623183
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.54985089
130EGR1_19032775_ChIP-ChIP_M12_Human0.54516036
131BCOR_27268052_Chip-Seq_Bcells_Human0.53992284
132SOX2_18692474_ChIP-Seq_MEFs_Mouse0.53296512
133AR_20517297_ChIP-Seq_VCAP_Human0.52543088
134P53_21459846_ChIP-Seq_SAOS-2_Human0.52278698
135P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.51631049
136OCT4_18692474_ChIP-Seq_MEFs_Mouse0.51609807
137* TP63_22573176_ChIP-Seq_HFKS_Human0.47976409
138ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.47650974
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.47395406
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47277830
141HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.46246335
142GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.46141659
143IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.45949305
144* CREB1_26743006_Chip-Seq_LNCaP_Human0.44868771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.17304962
2MP0005360_urolithiasis6.51574972
3MP0005085_abnormal_gallbladder_physiolo5.78282723
4MP0005365_abnormal_bile_salt5.50270353
5MP0008875_abnormal_xenobiotic_pharmacok4.40526121
6MP0003806_abnormal_nucleotide_metabolis3.59438822
7MP0003252_abnormal_bile_duct3.36899251
8MP0010329_abnormal_lipoprotein_level3.12166429
9MP0009840_abnormal_foam_cell3.10247744
10MP0005083_abnormal_biliary_tract3.08519003
11MP0001666_abnormal_nutrient_absorption2.92767329
12MP0005332_abnormal_amino_acid2.53325322
13MP0003195_calcinosis2.47640630
14MP0002796_impaired_skin_barrier2.47012142
15MP0004019_abnormal_vitamin_homeostasis2.43225863
16MP0009780_abnormal_chondrocyte_physiolo2.19632810
17MP0003191_abnormal_cellular_cholesterol2.15210617
18MP0010234_abnormal_vibrissa_follicle2.08842938
19MP0000537_abnormal_urethra_morphology2.05421774
20MP0005076_abnormal_cell_differentiation2.00540765
21MP0002138_abnormal_hepatobiliary_system2.00138350
22MP0003705_abnormal_hypodermis_morpholog1.96873287
23MP0002254_reproductive_system_inflammat1.95393631
24MP0000609_abnormal_liver_physiology1.92095164
25MP0002118_abnormal_lipid_homeostasis1.86329120
26MP0005451_abnormal_body_composition1.86050763
27MP0003693_abnormal_embryo_hatching1.69114467
28MP0005409_darkened_coat_color1.65264732
29MP0000678_abnormal_parathyroid_gland1.60779283
30MP0003868_abnormal_feces_composition1.60122109
31MP0005319_abnormal_enzyme/_coenzyme1.57019159
32MP0000579_abnormal_nail_morphology1.54990010
33MP0001849_ear_inflammation1.52240276
34MP0010352_gastrointestinal_tract_polyps1.46947909
35MP0003878_abnormal_ear_physiology1.39233271
36MP0005377_hearing/vestibular/ear_phenot1.39233271
37MP0003011_delayed_dark_adaptation1.38522491
38MP0005501_abnormal_skin_physiology1.38342234
39MP0002249_abnormal_larynx_morphology1.37875191
40MP0009643_abnormal_urine_homeostasis1.37716959
41MP0001764_abnormal_homeostasis1.33117605
42MP0004381_abnormal_hair_follicle1.32600100
43MP0002098_abnormal_vibrissa_morphology1.29055873
44MP0002060_abnormal_skin_morphology1.26641410
45MP0004957_abnormal_blastocyst_morpholog1.24064083
46MP0003186_abnormal_redox_activity1.18030278
47MP0004233_abnormal_muscle_weight1.17094905
48MP0003453_abnormal_keratinocyte_physiol1.16654017
49MP0001216_abnormal_epidermal_layer1.16285132
50MP0005275_abnormal_skin_tensile1.15432084
51MP0010030_abnormal_orbit_morphology1.15356005
52MP0003123_paternal_imprinting1.15289548
53MP0005584_abnormal_enzyme/coenzyme_acti1.14321039
54MP0000462_abnormal_digestive_system1.12589959
55MP0002089_abnormal_postnatal_growth/wei1.10694397
56MP0010678_abnormal_skin_adnexa1.10011615
57MP0009053_abnormal_anal_canal1.06478247
58MP0000377_abnormal_hair_follicle1.05679162
59MP0000647_abnormal_sebaceous_gland1.05303368
60MP0009697_abnormal_copulation1.04660869
61MP0001873_stomach_inflammation1.04090440
62MP0000383_abnormal_hair_follicle1.02862247
63MP0005647_abnormal_sex_gland1.02123118
64MP0005220_abnormal_exocrine_pancreas1.01770847
65MP0003315_abnormal_perineum_morphology1.00590403
66MP0004264_abnormal_extraembryonic_tissu0.99595602
67MP0004858_abnormal_nervous_system0.99555963
68MP0000598_abnormal_liver_morphology0.99481274
69MP0005636_abnormal_mineral_homeostasis0.98224641
70MP0004782_abnormal_surfactant_physiolog0.97786322
71MP0005408_hypopigmentation0.92765232
72MP0003936_abnormal_reproductive_system0.88447846
73MP0001756_abnormal_urination0.87475130
74MP0000566_synostosis0.87214144
75MP0000427_abnormal_hair_cycle0.86267745
76MP0000470_abnormal_stomach_morphology0.84411993
77MP0003718_maternal_effect0.83947865
78MP0005084_abnormal_gallbladder_morpholo0.82509651
79MP0001730_embryonic_growth_arrest0.81510977
80MP0000467_abnormal_esophagus_morphology0.80450603
81MP0003656_abnormal_erythrocyte_physiolo0.79983921
82MP0001727_abnormal_embryo_implantation0.79193449
83MP0004947_skin_inflammation0.79140017
84MP0002697_abnormal_eye_size0.78675464
85MP0002086_abnormal_extraembryonic_tissu0.78663700
86MP0003942_abnormal_urinary_system0.78352444
87MP0000477_abnormal_intestine_morphology0.77121265
88MP0010771_integument_phenotype0.76967573
89MP0001672_abnormal_embryogenesis/_devel0.76172547
90MP0005380_embryogenesis_phenotype0.76172547
91MP0002111_abnormal_tail_morphology0.76128452
92MP0010368_abnormal_lymphatic_system0.76022981
93MP0001765_abnormal_ion_homeostasis0.75464094
94MP0002909_abnormal_adrenal_gland0.75320604
95MP0009764_decreased_sensitivity_to0.74781683
96MP0009763_increased_sensitivity_to0.74775902
97MP0002088_abnormal_embryonic_growth/wei0.74548416
98MP0003984_embryonic_growth_retardation0.73943243
99MP0009642_abnormal_blood_homeostasis0.71538719
100MP0003115_abnormal_respiratory_system0.71244427
101MP0001243_abnormal_dermal_layer0.70472097
102MP0003941_abnormal_skin_development0.68960050
103MP0001661_extended_life_span0.68309727
104MP0008469_abnormal_protein_level0.68177286
105MP0004197_abnormal_fetal_growth/weight/0.66423318
106MP0009379_abnormal_foot_pigmentation0.65621237
107MP0000604_amyloidosis0.65179061
108MP0001919_abnormal_reproductive_system0.64559554
109MP0000003_abnormal_adipose_tissue0.64516275
110MP0002136_abnormal_kidney_physiology0.64375676
111MP0001340_abnormal_eyelid_morphology0.64174873
112MP0009931_abnormal_skin_appearance0.64163213
113MP0002085_abnormal_embryonic_tissue0.63831930
114MP0002080_prenatal_lethality0.63247025
115MP0009765_abnormal_xenobiotic_induced0.61639735
116MP0009703_decreased_birth_body0.59588960
117MP0005395_other_phenotype0.59154123
118MP0000367_abnormal_coat/_hair0.59014472
119MP0004185_abnormal_adipocyte_glucose0.58957757
120MP0006036_abnormal_mitochondrial_physio0.58566226
121MP0005248_abnormal_Harderian_gland0.58372510
122MP0002971_abnormal_brown_adipose0.57971420
123MP0001881_abnormal_mammary_gland0.57534931
124MP0009384_cardiac_valve_regurgitation0.57026717
125MP0002078_abnormal_glucose_homeostasis0.54164277
126MP0001191_abnormal_skin_condition0.53333881
127MP0005376_homeostasis/metabolism_phenot0.53328184
128MP0005023_abnormal_wound_healing0.53165065
129MP0005334_abnormal_fat_pad0.52844353
130MP0002132_abnormal_respiratory_system0.50997566
131MP0003638_abnormal_response/metabolism_0.50889241
132MP0001346_abnormal_lacrimal_gland0.49840898
133MP0005666_abnormal_adipose_tissue0.46788087
134MP0002876_abnormal_thyroid_physiology0.45939635
135MP0003566_abnormal_cell_adhesion0.44615866
136MP0005670_abnormal_white_adipose0.42325305
137MP0000627_abnormal_mammary_gland0.40162682
138MP0009672_abnormal_birth_weight0.39181269
139MP0005266_abnormal_metabolism0.39089739
140MP0005448_abnormal_energy_balance0.38366001
141MP0000762_abnormal_tongue_morphology0.38298343
142MP0004130_abnormal_muscle_cell0.37860663
143MP0000538_abnormal_urinary_bladder0.36581283

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.82691452
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.70129547
3Deep venous thrombosis (HP:0002625)6.44298667
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.33426820
5Xanthomatosis (HP:0000991)6.00848561
6Prolonged partial thromboplastin time (HP:0003645)5.71901396
7Hypobetalipoproteinemia (HP:0003563)5.68692681
8Hyperlipoproteinemia (HP:0010980)5.04536810
9Hyperglycinemia (HP:0002154)4.83147290
10Complement deficiency (HP:0004431)4.63516646
11Hyperglycinuria (HP:0003108)4.51206159
12Pili torti (HP:0003777)4.45147034
13Hypolipoproteinemia (HP:0010981)4.41217150
14Hyperammonemia (HP:0001987)4.31632446
15Abnormality of serine family amino acid metabolism (HP:0010894)4.29162218
16Abnormality of glycine metabolism (HP:0010895)4.29162218
17Septate vagina (HP:0001153)4.25460161
18Epidermoid cyst (HP:0200040)4.06419451
19Fat malabsorption (HP:0002630)4.03624260
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.01577849
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.01419009
22Abnormality of the common coagulation pathway (HP:0010990)3.98787642
23Hypoalphalipoproteinemia (HP:0003233)3.98363460
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.95588157
25Joint hemorrhage (HP:0005261)3.94410220
26Ketosis (HP:0001946)3.85241476
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.76885125
28Abnormality of methionine metabolism (HP:0010901)3.72507885
29Hypoglycemic coma (HP:0001325)3.64503721
30Lip pit (HP:0100267)3.64273801
31Flat acetabular roof (HP:0003180)3.52953130
32Abnormality of complement system (HP:0005339)3.49078832
33Gout (HP:0001997)3.48089477
34Abnormality of the intrinsic pathway (HP:0010989)3.43887362
35Conjugated hyperbilirubinemia (HP:0002908)3.43124679
36Abnormality of pyrimidine metabolism (HP:0004353)3.37560703
37Asymmetry of the thorax (HP:0001555)3.21742707
38Abnormality of fatty-acid metabolism (HP:0004359)3.18851778
39Hypercholesterolemia (HP:0003124)3.12498492
40Abnormality of serum amino acid levels (HP:0003112)3.12250950
41Abnormality of nucleobase metabolism (HP:0010932)3.10906963
42Steatorrhea (HP:0002570)3.08497619
43Amelogenesis imperfecta (HP:0000705)3.01175435
44Hypotrichosis (HP:0001006)3.01009601
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.00402448
46Abnormality of purine metabolism (HP:0004352)2.97580093
47Delayed CNS myelination (HP:0002188)2.91251877
48Fragile nails (HP:0001808)2.90866368
49Sparse lateral eyebrow (HP:0005338)2.88824185
50Myocardial infarction (HP:0001658)2.88164427
51Malnutrition (HP:0004395)2.88019882
52Vascular calcification (HP:0004934)2.84066436
53Pterygium (HP:0001059)2.82042911
54Palmoplantar hyperkeratosis (HP:0000972)2.80009473
55Hyperbilirubinemia (HP:0002904)2.79331359
56Congenital ichthyosiform erythroderma (HP:0007431)2.79202686
57Advanced eruption of teeth (HP:0006288)2.78558398
58Ketoacidosis (HP:0001993)2.77617738
59Curly hair (HP:0002212)2.72680210
60Spontaneous abortion (HP:0005268)2.70340363
61Dicarboxylic aciduria (HP:0003215)2.69946514
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.69946514
63Right ventricular cardiomyopathy (HP:0011663)2.66793456
64Hepatocellular carcinoma (HP:0001402)2.66452906
65Concave nail (HP:0001598)2.64418961
66Lethargy (HP:0001254)2.61788773
67Germ cell neoplasia (HP:0100728)2.59677740
68Palmar hyperkeratosis (HP:0010765)2.59528684
69Sparse eyelashes (HP:0000653)2.56175678
70Abnormality of the salivary glands (HP:0010286)2.55802077
71Metabolic acidosis (HP:0001942)2.53909087
72Abnormality of the distal phalanges of the toes (HP:0010182)2.53785405
73Milia (HP:0001056)2.50863946
74Thin bony cortex (HP:0002753)2.50260253
75J-shaped sella turcica (HP:0002680)2.49693261
76Cardiovascular calcification (HP:0011915)2.49448728
77Abnormality of the gastric mucosa (HP:0004295)2.43542246
78Esophageal varix (HP:0002040)2.36604950
79Hyperactive renin-angiotensin system (HP:0000841)2.34720952
80Spastic diplegia (HP:0001264)2.33919334
81Irritability (HP:0000737)2.27117291
82Absent eyelashes (HP:0000561)2.25817586
83Hypochromic microcytic anemia (HP:0004840)2.24929602
84Nail dystrophy (HP:0008404)2.24557483
85Abdominal distention (HP:0003270)2.23128329
86Micronodular cirrhosis (HP:0001413)2.22568514
87Skin nodule (HP:0200036)2.22272035
88Neonatal onset (HP:0003623)2.20680530
89Increased purine levels (HP:0004368)2.19446833
90Hyperuricemia (HP:0002149)2.19446833
91Selective tooth agenesis (HP:0001592)2.19172106
92Popliteal pterygium (HP:0009756)2.18765285
93Abnormality of the dental root (HP:0006486)2.18480610
94Taurodontia (HP:0000679)2.18480610
95Abnormality of permanent molar morphology (HP:0011071)2.18480610
96Systemic lupus erythematosus (HP:0002725)2.17666888
97Hypoplasia of dental enamel (HP:0006297)2.13515720
98Brushfield spots (HP:0001088)2.13447889
99Rickets (HP:0002748)2.12996784
100Cerebral edema (HP:0002181)2.11109389
101Pancreatitis (HP:0001733)2.10575625
102Hypoglycemic seizures (HP:0002173)2.09689197
103Abnormal cartilage morphology (HP:0002763)2.09091668
104Glomerulonephritis (HP:0000099)2.08868474
105Alopecia of scalp (HP:0002293)2.08582093
106Late onset (HP:0003584)2.08276018
107Testicular atrophy (HP:0000029)2.04399933
108Hyperglycemia (HP:0003074)2.04334911
109Generalized aminoaciduria (HP:0002909)2.03870238
110Acanthocytosis (HP:0001927)2.03664220
111Thick nail (HP:0001805)2.03206095
112Ridged nail (HP:0001807)2.02967598
113Abnormality of the lacrimal duct (HP:0011481)2.02356664
114Plantar hyperkeratosis (HP:0007556)1.99343950
115Abnormal tarsal ossification (HP:0008369)1.97831852
116Onycholysis (HP:0001806)1.97298355
117Breast carcinoma (HP:0003002)1.95617451
118Amyloidosis (HP:0011034)1.95327725
119Abnormality of the dental pulp (HP:0006479)1.94639918
120Abnormality of transition element cation homeostasis (HP:0011030)1.94506478
121Chronic bronchitis (HP:0004469)1.93313880
122Abnormal gallbladder morphology (HP:0012437)1.93086080
123Vomiting (HP:0002013)1.92117778
124Nasolacrimal duct obstruction (HP:0000579)1.91972211
125Bronchomalacia (HP:0002780)1.91529126
126Abnormality of molar morphology (HP:0011070)1.91175949
127Abnormality of molar (HP:0011077)1.91175949
128Menorrhagia (HP:0000132)1.90454138
129Bifid scrotum (HP:0000048)1.89937882
130Distal lower limb muscle weakness (HP:0009053)1.89066953
131Hypophosphatemic rickets (HP:0004912)1.88984916
132Broad face (HP:0000283)1.88681289
133Woolly hair (HP:0002224)1.88623647
134Cholelithiasis (HP:0001081)1.88537736
135Abnormality of the distal phalanx of the thumb (HP:0009617)1.87003461
136Alkalosis (HP:0001948)1.86772218
137Abnormality of nail color (HP:0100643)1.85152398
138Abnormal enzyme/coenzyme activity (HP:0012379)1.83742013
139Spinal cord compression (HP:0002176)1.83372188
140Abnormality of iron homeostasis (HP:0011031)1.82955673
141Proximal tubulopathy (HP:0000114)1.82678448
142Hemorrhage of the eye (HP:0011885)1.82521887
143Hydroxyprolinuria (HP:0003080)1.82512382
144Abnormality of proline metabolism (HP:0010907)1.82512382
145Opisthotonus (HP:0002179)1.81905196
146Abnormal hemoglobin (HP:0011902)1.81668812
147Abnormality of urine glucose concentration (HP:0011016)1.81227706
148Glycosuria (HP:0003076)1.81227706
149Enlarged kidneys (HP:0000105)1.80932565
150Natal tooth (HP:0000695)1.80354639
151Abnormality of the nasal septum (HP:0000419)1.80340335
152Gingival bleeding (HP:0000225)1.80255686
153Hypoparathyroidism (HP:0000829)1.80076901
154Abnormal hair laboratory examination (HP:0003328)1.77615545
155Deviation of the thumb (HP:0009603)1.77465582
156Hyperacusis (HP:0010780)1.77211831
157Mitral stenosis (HP:0001718)1.76368600
158Microglossia (HP:0000171)1.71691028
159Seborrheic dermatitis (HP:0001051)1.71126072
160Trismus (HP:0000211)1.70850122
161Lymphangioma (HP:0100764)1.69372142
162Widely patent fontanelles and sutures (HP:0004492)1.68574692
163Anal stenosis (HP:0002025)1.68052331
164Short nail (HP:0001799)1.67353008
165Depressed nasal tip (HP:0000437)1.65634413
166Blepharitis (HP:0000498)1.63513134
167Abnormality of carpal bone ossification (HP:0006257)1.61888374
168Oligodontia (HP:0000677)1.57183459
169Abnormality of secondary sexual hair (HP:0009888)1.56850720
170Abnormality of the axillary hair (HP:0100134)1.56850720
171Neonatal death (HP:0003811)1.56334853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.69360051
2ERN14.17748189
3MST1R4.10341533
4FGFR43.83310985
5SIK13.59472872
6EPHA23.17649675
7SMG13.17290711
8LATS12.85450427
9EEF2K2.55967779
10CDK122.25602331
11MAP3K32.10854767
12TAOK32.04263686
13INSRR1.97719529
14ERBB41.94569178
15ICK1.89012867
16FRK1.86357947
17SCYL21.85842330
18TRIB31.79396953
19PTK61.73500651
20PIK3CG1.72818187
21MET1.72566850
22PAK41.62796602
23TESK11.51921121
24FER1.45825689
25MAPK111.43775720
26IRAK31.41568481
27AKT31.40934505
28STK38L1.40861010
29MAPKAPK31.38824096
30TYK21.38580757
31NEK91.37984964
32MAP2K21.36710537
33PIK3CA1.36171440
34NME21.35806283
35MAP3K91.35398683
36MUSK1.35010686
37MAPK151.33827983
38NEK61.32789745
39RPS6KB21.28182673
40PKN21.27341587
41NME11.27074024
42CDK71.22563692
43FGFR21.22178210
44EPHB21.11715154
45LMTK21.11629646
46ERBB21.10068193
47CDK61.05543012
48DYRK1B1.00308179
49MST40.99376116
50EPHA30.97587438
51ABL20.95084997
52FLT30.94503444
53STK390.92915038
54MAP3K110.92690996
55MAP3K20.88050342
56EPHB10.86385126
57PTK20.86155808
58MAP3K120.86148377
59PDK30.83981616
60PDK40.83981616
61MAP3K70.82951881
62CAMK1G0.82651753
63MAP2K40.82173881
64EIF2AK10.82110491
65PRKAA20.81646220
66MAP3K100.81384370
67JAK20.79348901
68RPS6KA20.79280307
69STK30.78173590
70VRK20.78122160
71TAOK10.77864653
72LRRK20.75704406
73CHUK0.75477597
74ILK0.74618527
75MAP2K60.74446339
76MAP2K30.74083255
77PINK10.73048830
78KDR0.71459295
79NUAK10.67976597
80GSK3A0.66311205
81MAP3K60.65836119
82PRKD30.65194623
83PDGFRA0.64803141
84MAP2K10.63936205
85RIPK10.63095578
86GRK10.62737144
87TESK20.61214560
88STK100.59264542
89PRKCI0.58591013
90MAPK40.55290496
91MTOR0.54226325
92TSSK60.54137268
93RPS6KB10.53364577
94LATS20.52902803
95CDK40.52530747
96TAF10.51923429
97RET0.51556986
98TGFBR20.49741856
99PIM20.49490569
100PDK20.47624371
101RPS6KA40.47415354
102PRKCZ0.47232386
103TBK10.46364098
104CAMK2G0.45324897
105JAK10.44522508
106PRKAA10.44031203
107DYRK30.43662591
108DMPK0.42065407
109FGFR30.41086417
110GRK60.41051697
111PBK0.40471674
112BMX0.40470781
113AURKB0.39453695
114CSNK1G10.39216758
115MAPKAPK20.39132498
116TTK0.38484202
117FGFR10.38434859
118WNK40.38336099
119PRKACG0.38196045
120AKT20.37890454
121BRSK20.37741376
122BUB10.37672787
123ACVR1B0.36670555
124MAP3K80.36190595
125NLK0.36088162
126DAPK20.35759536
127RPS6KA10.35701801
128CSK0.35085283
129AURKA0.34380531
130RPS6KC10.33258251
131RPS6KL10.33258251
132MAP3K10.30714337
133PRKD20.29733605
134CAMK1D0.29478083
135MAP3K140.29416810
136MAP3K50.29088625
137IRAK10.28482804
138CSNK1E0.28203274
139PRKG20.27882742
140BRD40.27846662
141MELK0.26998276
142STK240.26842630
143STK380.26711067
144SIK30.26167820
145PDPK10.25906592
146TIE10.25855317
147PAK20.24887758
148SRPK10.24228886
149CHEK10.23338406
150BRSK10.22952085
151MAPK80.22926575
152IRAK20.22558178
153RPS6KA60.20725442

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.12693029
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28855320
3Nitrogen metabolism_Homo sapiens_hsa009103.16156634
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.87823778
5Arginine biosynthesis_Homo sapiens_hsa002202.76608176
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.69869145
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.69011307
8Tryptophan metabolism_Homo sapiens_hsa003802.59248691
9Fatty acid degradation_Homo sapiens_hsa000712.47556479
10Complement and coagulation cascades_Homo sapiens_hsa046102.45011340
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37189057
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33892602
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29690372
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20649493
15Histidine metabolism_Homo sapiens_hsa003402.10375747
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.06077745
17Butanoate metabolism_Homo sapiens_hsa006502.02429346
18Peroxisome_Homo sapiens_hsa041462.00315314
19Chemical carcinogenesis_Homo sapiens_hsa052041.99449827
20Propanoate metabolism_Homo sapiens_hsa006401.83043606
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.82335558
22Retinol metabolism_Homo sapiens_hsa008301.82097521
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.80294679
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.79678042
25beta-Alanine metabolism_Homo sapiens_hsa004101.79265341
26PPAR signaling pathway_Homo sapiens_hsa033201.78765737
27Caffeine metabolism_Homo sapiens_hsa002321.78080630
28Fatty acid metabolism_Homo sapiens_hsa012121.72573651
29Phenylalanine metabolism_Homo sapiens_hsa003601.63950220
30Folate biosynthesis_Homo sapiens_hsa007901.62684035
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.62277269
32Selenocompound metabolism_Homo sapiens_hsa004501.61073302
33Sulfur metabolism_Homo sapiens_hsa009201.55788618
34Fat digestion and absorption_Homo sapiens_hsa049751.53284097
35Staphylococcus aureus infection_Homo sapiens_hsa051501.52150221
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49184169
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49015153
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44663637
39Tyrosine metabolism_Homo sapiens_hsa003501.42854351
40Fatty acid elongation_Homo sapiens_hsa000621.42254592
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38005890
42Vitamin B6 metabolism_Homo sapiens_hsa007501.35620587
43Bile secretion_Homo sapiens_hsa049761.34524017
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.30357668
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.30199332
46Pyruvate metabolism_Homo sapiens_hsa006201.23060981
47Tight junction_Homo sapiens_hsa045301.21747095
48Vitamin digestion and absorption_Homo sapiens_hsa049771.21664907
49Biosynthesis of amino acids_Homo sapiens_hsa012301.19421718
50Steroid biosynthesis_Homo sapiens_hsa001001.17912776
51Starch and sucrose metabolism_Homo sapiens_hsa005001.16966698
52Sulfur relay system_Homo sapiens_hsa041221.14303525
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12548644
54ABC transporters_Homo sapiens_hsa020101.12384614
55Carbon metabolism_Homo sapiens_hsa012001.11011147
56Endometrial cancer_Homo sapiens_hsa052131.02180854
57Arginine and proline metabolism_Homo sapiens_hsa003301.00519032
58Glutathione metabolism_Homo sapiens_hsa004800.94114379
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93469112
60Notch signaling pathway_Homo sapiens_hsa043300.86870238
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84479128
62Adherens junction_Homo sapiens_hsa045200.84035000
63One carbon pool by folate_Homo sapiens_hsa006700.78928687
64Glycerolipid metabolism_Homo sapiens_hsa005610.78690302
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78049856
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77457139
67Lysine degradation_Homo sapiens_hsa003100.75001470
68Pentose phosphate pathway_Homo sapiens_hsa000300.71856682
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70108367
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70058031
71N-Glycan biosynthesis_Homo sapiens_hsa005100.69858769
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68546884
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67807372
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67558794
75Prostate cancer_Homo sapiens_hsa052150.66782440
76Linoleic acid metabolism_Homo sapiens_hsa005910.66061165
77Hippo signaling pathway_Homo sapiens_hsa043900.65672339
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61495691
79Fatty acid biosynthesis_Homo sapiens_hsa000610.59410873
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59145078
81Other glycan degradation_Homo sapiens_hsa005110.58125382
82Acute myeloid leukemia_Homo sapiens_hsa052210.56292278
83Metabolic pathways_Homo sapiens_hsa011000.52004190
84ErbB signaling pathway_Homo sapiens_hsa040120.51036488
85VEGF signaling pathway_Homo sapiens_hsa043700.50483155
86mTOR signaling pathway_Homo sapiens_hsa041500.47308782
87Small cell lung cancer_Homo sapiens_hsa052220.46267595
88Chronic myeloid leukemia_Homo sapiens_hsa052200.45899698
89Choline metabolism in cancer_Homo sapiens_hsa052310.44966879
90mRNA surveillance pathway_Homo sapiens_hsa030150.44635871
91Proteoglycans in cancer_Homo sapiens_hsa052050.41543504
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39752601
93Non-small cell lung cancer_Homo sapiens_hsa052230.39208899
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.37833860
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37016661
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36204987
97Fructose and mannose metabolism_Homo sapiens_hsa000510.35688324
98Galactose metabolism_Homo sapiens_hsa000520.31833141
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30974726
100Insulin resistance_Homo sapiens_hsa049310.22740390
101Arachidonic acid metabolism_Homo sapiens_hsa005900.21705383
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19302972
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.18206288
104Prion diseases_Homo sapiens_hsa050200.17431133
105Regulation of autophagy_Homo sapiens_hsa041400.15238015
106Mineral absorption_Homo sapiens_hsa049780.04954952
107Bladder cancer_Homo sapiens_hsa052190.04381134
108Protein digestion and absorption_Homo sapiens_hsa049740.02093001
109AMPK signaling pathway_Homo sapiens_hsa041520.01609595
110Thyroid cancer_Homo sapiens_hsa05216-0.1797792
111Pancreatic secretion_Homo sapiens_hsa04972-0.1741280
112Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1732511
113Sphingolipid metabolism_Homo sapiens_hsa00600-0.1663098
114Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1448140
115Amoebiasis_Homo sapiens_hsa05146-0.1443716
116Insulin signaling pathway_Homo sapiens_hsa04910-0.1344382
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1190419
118Pyrimidine metabolism_Homo sapiens_hsa00240-0.0992718
119Hepatitis C_Homo sapiens_hsa05160-0.0551532
120Ether lipid metabolism_Homo sapiens_hsa00565-0.0489800
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0367841
122Ribosome_Homo sapiens_hsa03010-0.0351155
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0172220
124Renin-angiotensin system_Homo sapiens_hsa04614-0.0097360
125Glucagon signaling pathway_Homo sapiens_hsa04922-0.0091786

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