Rank | Gene Set | Z-score |
---|---|---|
1 | desmosome organization (GO:0002934) | 7.80729170 |
2 | L-phenylalanine catabolic process (GO:0006559) | 6.99370359 |
3 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 6.99370359 |
4 | L-phenylalanine metabolic process (GO:0006558) | 6.75602841 |
5 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 6.75602841 |
6 | aromatic amino acid family catabolic process (GO:0009074) | 6.26984640 |
7 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 5.85520147 |
8 | indole-containing compound catabolic process (GO:0042436) | 5.73816659 |
9 | indolalkylamine catabolic process (GO:0046218) | 5.73816659 |
10 | tryptophan catabolic process (GO:0006569) | 5.73816659 |
11 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 5.67398464 |
12 | regulation of water loss via skin (GO:0033561) | 5.65844091 |
13 | kynurenine metabolic process (GO:0070189) | 5.61735868 |
14 | cysteine metabolic process (GO:0006534) | 5.57323894 |
15 | sulfur amino acid catabolic process (GO:0000098) | 5.43598185 |
16 | glyoxylate metabolic process (GO:0046487) | 5.41491262 |
17 | tryptophan metabolic process (GO:0006568) | 5.40843997 |
18 | bile acid biosynthetic process (GO:0006699) | 5.36763475 |
19 | serine family amino acid catabolic process (GO:0009071) | 5.28458334 |
20 | urea cycle (GO:0000050) | 5.23764734 |
21 | urea metabolic process (GO:0019627) | 5.23764734 |
22 | intestinal epithelial cell development (GO:0060576) | 5.08769093 |
23 | establishment of skin barrier (GO:0061436) | 5.04998717 |
24 | negative regulation of fibrinolysis (GO:0051918) | 5.03024832 |
25 | high-density lipoprotein particle remodeling (GO:0034375) | 4.98356583 |
26 | protein carboxylation (GO:0018214) | 4.95552659 |
27 | peptidyl-glutamic acid carboxylation (GO:0017187) | 4.95552659 |
28 | alpha-linolenic acid metabolic process (GO:0036109) | 4.90900006 |
29 | regulation of fibrinolysis (GO:0051917) | 4.88765577 |
30 | regulation of protein activation cascade (GO:2000257) | 4.87703722 |
31 | homocysteine metabolic process (GO:0050667) | 4.84330097 |
32 | nitrogen cycle metabolic process (GO:0071941) | 4.80114881 |
33 | amino-acid betaine metabolic process (GO:0006577) | 4.75021773 |
34 | complement activation, alternative pathway (GO:0006957) | 4.72689225 |
35 | aromatic amino acid family metabolic process (GO:0009072) | 4.70051045 |
36 | glycine metabolic process (GO:0006544) | 4.69227692 |
37 | bile acid metabolic process (GO:0008206) | 4.65180110 |
38 | regulation of triglyceride catabolic process (GO:0010896) | 4.56592720 |
39 | regulation of complement activation (GO:0030449) | 4.55450895 |
40 | multicellular organismal water homeostasis (GO:0050891) | 4.48047070 |
41 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.45545492 |
42 | negative regulation of cholesterol transport (GO:0032375) | 4.45113971 |
43 | negative regulation of sterol transport (GO:0032372) | 4.45113971 |
44 | serine family amino acid metabolic process (GO:0009069) | 4.40785637 |
45 | regulation of cholesterol esterification (GO:0010872) | 4.36932898 |
46 | alpha-amino acid catabolic process (GO:1901606) | 4.35173951 |
47 | lysine catabolic process (GO:0006554) | 4.33195877 |
48 | lysine metabolic process (GO:0006553) | 4.33195877 |
49 | reverse cholesterol transport (GO:0043691) | 4.31938337 |
50 | phospholipid efflux (GO:0033700) | 4.29992738 |
51 | triglyceride homeostasis (GO:0070328) | 4.29947840 |
52 | acylglycerol homeostasis (GO:0055090) | 4.29947840 |
53 | tyrosine metabolic process (GO:0006570) | 4.25316519 |
54 | plasma lipoprotein particle remodeling (GO:0034369) | 4.21306649 |
55 | protein-lipid complex remodeling (GO:0034368) | 4.21306649 |
56 | macromolecular complex remodeling (GO:0034367) | 4.21306649 |
57 | serine family amino acid biosynthetic process (GO:0009070) | 4.18061673 |
58 | bile acid and bile salt transport (GO:0015721) | 4.18003020 |
59 | hemidesmosome assembly (GO:0031581) | 4.15082508 |
60 | regulation of branching involved in prostate gland morphogenesis (GO:0060687) | 4.13184869 |
61 | imidazole-containing compound metabolic process (GO:0052803) | 4.11832622 |
62 | positive regulation of keratinocyte differentiation (GO:0045618) | 4.10663080 |
63 | cellular amino acid catabolic process (GO:0009063) | 4.06486884 |
64 | proline biosynthetic process (GO:0006561) | 4.03931409 |
65 | indolalkylamine metabolic process (GO:0006586) | 4.02081974 |
66 | regulation of cholesterol homeostasis (GO:2000188) | 3.99554376 |
67 | cellular glucuronidation (GO:0052695) | 3.98945312 |
68 | cellular modified amino acid catabolic process (GO:0042219) | 3.98113779 |
69 | fibrinolysis (GO:0042730) | 3.96017550 |
70 | cellular ketone body metabolic process (GO:0046950) | 3.95922188 |
71 | cellular biogenic amine catabolic process (GO:0042402) | 3.95807888 |
72 | amine catabolic process (GO:0009310) | 3.95807888 |
73 | biotin metabolic process (GO:0006768) | 3.95520441 |
74 | gap junction assembly (GO:0016264) | 3.91722009 |
75 | positive regulation of epidermal cell differentiation (GO:0045606) | 3.90626460 |
76 | plasma lipoprotein particle clearance (GO:0034381) | 3.89109228 |
77 | ethanol oxidation (GO:0006069) | 3.89045147 |
78 | glutamate metabolic process (GO:0006536) | 3.86792140 |
79 | proline metabolic process (GO:0006560) | 3.85467446 |
80 | benzene-containing compound metabolic process (GO:0042537) | 3.85093551 |
81 | coenzyme catabolic process (GO:0009109) | 3.81958860 |
82 | intestinal cholesterol absorption (GO:0030299) | 3.79320837 |
83 | drug catabolic process (GO:0042737) | 3.78496906 |
84 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.77068057 |
85 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.77068057 |
86 | regulation of bile acid biosynthetic process (GO:0070857) | 3.75349410 |
87 | cholesterol efflux (GO:0033344) | 3.74346254 |
88 | cholesterol homeostasis (GO:0042632) | 3.68475338 |
89 | water homeostasis (GO:0030104) | 3.67799790 |
90 | sterol homeostasis (GO:0055092) | 3.63227131 |
91 | arginine metabolic process (GO:0006525) | 3.62997617 |
92 | negative regulation of lipase activity (GO:0060192) | 3.61655792 |
93 | establishment of apical/basal cell polarity (GO:0035089) | 3.59611672 |
94 | carboxylic acid catabolic process (GO:0046395) | 3.58489336 |
95 | organic acid catabolic process (GO:0016054) | 3.58489336 |
96 | epithelial cell-cell adhesion (GO:0090136) | 3.58433162 |
97 | plasma lipoprotein particle assembly (GO:0034377) | 3.58099101 |
98 | urate metabolic process (GO:0046415) | 3.57685265 |
99 | branching involved in mammary gland duct morphogenesis (GO:0060444) | 3.56645714 |
100 | uronic acid metabolic process (GO:0006063) | 3.54325303 |
101 | glucuronate metabolic process (GO:0019585) | 3.54325303 |
102 | COPI coating of Golgi vesicle (GO:0048205) | 3.51493869 |
103 | Golgi transport vesicle coating (GO:0048200) | 3.51493869 |
104 | short-chain fatty acid metabolic process (GO:0046459) | 3.49745601 |
105 | carnitine metabolic process (GO:0009437) | 3.47816307 |
106 | blood coagulation, intrinsic pathway (GO:0007597) | 3.46161326 |
107 | positive regulation of lipid catabolic process (GO:0050996) | 3.43926859 |
108 | phospholipid homeostasis (GO:0055091) | 3.40901480 |
109 | ketone body metabolic process (GO:1902224) | 3.40548679 |
110 | aldehyde catabolic process (GO:0046185) | 3.38156082 |
111 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.38083903 |
112 | complement activation, classical pathway (GO:0006958) | 3.37809243 |
113 | acetyl-CoA metabolic process (GO:0006084) | 3.36804590 |
114 | complement activation (GO:0006956) | 3.36695510 |
115 | response to nitrosative stress (GO:0051409) | 3.35637569 |
116 | ethanol metabolic process (GO:0006067) | 3.34449890 |
117 | protein activation cascade (GO:0072376) | 3.33449071 |
118 | low-density lipoprotein particle remodeling (GO:0034374) | 3.33027171 |
119 | regulation of cholesterol biosynthetic process (GO:0045540) | 3.33010162 |
120 | fatty acid oxidation (GO:0019395) | 3.30643991 |
121 | drug transmembrane transport (GO:0006855) | 3.30305594 |
122 | ear development (GO:0043583) | 3.30083334 |
123 | positive regulation of Cdc42 GTPase activity (GO:0043089) | 3.27419327 |
124 | maternal placenta development (GO:0001893) | 3.26198902 |
125 | negative regulation of keratinocyte proliferation (GO:0010839) | 3.24816152 |
126 | epoxygenase P450 pathway (GO:0019373) | 3.24193554 |
127 | epithelial cell differentiation involved in prostate gland development (GO:0060742) | 3.20626659 |
128 | surfactant homeostasis (GO:0043129) | 3.20055524 |
129 | regulation of keratinocyte differentiation (GO:0045616) | 3.20051230 |
130 | L-alpha-amino acid transmembrane transport (GO:1902475) | 3.10691106 |
131 | polarized epithelial cell differentiation (GO:0030859) | 3.10240497 |
132 | keratinization (GO:0031424) | 3.07647223 |
133 | tight junction assembly (GO:0070830) | 3.04029846 |
134 | chemical homeostasis within a tissue (GO:0048875) | 3.03775626 |
135 | response to food (GO:0032094) | 3.02710922 |
136 | epithelial cell maturation (GO:0002070) | 3.02267377 |
137 | regulation of Wnt signaling pathway involved in heart development (GO:0003307) | 3.01919180 |
138 | regulation of fatty acid beta-oxidation (GO:0031998) | 3.01037751 |
139 | positive regulation of epidermis development (GO:0045684) | 2.97625361 |
140 | primary alcohol catabolic process (GO:0034310) | 2.92482287 |
141 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338) | 2.86918022 |
142 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.86844403 |
143 | trivalent inorganic anion homeostasis (GO:0072506) | 2.81928451 |
144 | phosphate ion homeostasis (GO:0055062) | 2.81928451 |
145 | branching involved in salivary gland morphogenesis (GO:0060445) | 2.81751334 |
146 | regulation of cell proliferation involved in kidney development (GO:1901722) | 2.80819744 |
147 | regulation of cell-cell adhesion mediated by cadherin (GO:2000047) | 2.79427358 |
148 | keratinocyte development (GO:0003334) | 2.77500355 |
149 | cardiac right ventricle morphogenesis (GO:0003215) | 2.74818241 |
150 | positive regulation of hormone metabolic process (GO:0032352) | 2.74737964 |
151 | positive regulation of cellular amine metabolic process (GO:0033240) | 2.73590559 |
152 | semaphorin-plexin signaling pathway (GO:0071526) | 2.72836732 |
153 | GDP-mannose metabolic process (GO:0019673) | 2.71530131 |
154 | establishment of monopolar cell polarity (GO:0061162) | 2.70374597 |
155 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 2.70374597 |
156 | trophectodermal cell differentiation (GO:0001829) | 2.69824469 |
157 | lung epithelium development (GO:0060428) | 2.69434618 |
158 | omega-hydroxylase P450 pathway (GO:0097267) | 2.65934904 |
159 | atrioventricular valve morphogenesis (GO:0003181) | 2.64587138 |
160 | negative regulation of cell size (GO:0045792) | 2.64540717 |
161 | activation of Rac GTPase activity (GO:0032863) | 2.62907827 |
162 | negative regulation of cell fate specification (GO:0009996) | 2.62890648 |
163 | negative regulation of cell fate commitment (GO:0010454) | 2.61941779 |
164 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.60735905 |
165 | regulation of cholesterol metabolic process (GO:0090181) | 2.58529863 |
166 | mammary gland epithelial cell differentiation (GO:0060644) | 2.57297374 |
167 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 2.56634772 |
168 | glutamine family amino acid biosynthetic process (GO:0009084) | 2.54976152 |
169 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 2.54018762 |
170 | keratinocyte proliferation (GO:0043616) | 2.52284415 |
171 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.51056196 |
172 | cell-cell junction assembly (GO:0007043) | 2.48925470 |
173 | embryonic eye morphogenesis (GO:0048048) | 2.48242840 |
174 | regulation of hippo signaling (GO:0035330) | 2.48230541 |
175 | ectoderm development (GO:0007398) | 2.48180662 |
176 | flavonoid metabolic process (GO:0009812) | 2.47549891 |
177 | cell-substrate junction assembly (GO:0007044) | 2.46239125 |
178 | focal adhesion assembly (GO:0048041) | 2.45624493 |
179 | cell-substrate adherens junction assembly (GO:0007045) | 2.45624493 |
180 | L-serine metabolic process (GO:0006563) | 2.45212469 |
181 | nucleotide-sugar biosynthetic process (GO:0009226) | 2.45120276 |
182 | cell differentiation involved in embryonic placenta development (GO:0060706) | 2.44924809 |
183 | columnar/cuboidal epithelial cell development (GO:0002066) | 2.44511878 |
184 | exogenous drug catabolic process (GO:0042738) | 2.44008306 |
185 | adherens junction assembly (GO:0034333) | 2.43681587 |
186 | 4-hydroxyproline metabolic process (GO:0019471) | 2.43292574 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 7.35433385 |
2 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 6.59286360 |
3 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 5.92468841 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 5.67394133 |
5 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 5.11825881 |
6 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.71300861 |
7 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 4.55351738 |
8 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 4.53237455 |
9 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 3.52904049 |
10 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.40733932 |
11 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 3.36169487 |
12 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.88865744 |
13 | * TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 2.59861890 |
14 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.30294375 |
15 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 2.08262689 |
16 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.07051044 |
17 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 10.4660150 |
18 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.97683591 |
19 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.95102913 |
20 | * STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.92006746 |
21 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.77062504 |
22 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.64488001 |
23 | GATA1_22025678_ChIP-Seq_K562_Human | 1.61682456 |
24 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.59412330 |
25 | * SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.56264308 |
26 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.52566217 |
27 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.50106130 |
28 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.49518936 |
29 | * GATA4_25053715_ChIP-Seq_YYC3_Human | 1.48285860 |
30 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.47887182 |
31 | CHD1_26751641_Chip-Seq_LNCaP_Human | 1.46833215 |
32 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.40909274 |
33 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.36694060 |
34 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.34249753 |
35 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.32761218 |
36 | * CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.31712040 |
37 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.31000575 |
38 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.30309168 |
39 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.29845625 |
40 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.28027458 |
41 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.26005719 |
42 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.25989913 |
43 | * KLF5_25053715_ChIP-Seq_YYC3_Human | 1.23930895 |
44 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.23457288 |
45 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.22555808 |
46 | P68_20966046_ChIP-Seq_HELA_Human | 1.22281027 |
47 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.21901433 |
48 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.21261184 |
49 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.20929163 |
50 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.14702951 |
51 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.14458775 |
52 | * GATA6_25053715_ChIP-Seq_YYC3_Human | 1.14420738 |
53 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.14046286 |
54 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.12156325 |
55 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.12142255 |
56 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.11467412 |
57 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.10960397 |
58 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.09910260 |
59 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.09369056 |
60 | * P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.07512626 |
61 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.06766144 |
62 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.06687123 |
63 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.06532391 |
64 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.05937623 |
65 | ELF5_23300383_ChIP-Seq_T47D_Human | 1.05393553 |
66 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.03039770 |
67 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.02557311 |
68 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.02010218 |
69 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.01381641 |
70 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.01359148 |
71 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.00081558 |
72 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.99034890 |
73 | MYC_22102868_ChIP-Seq_BL_Human | 0.98686147 |
74 | KDM2B_26808549_Chip-Seq_K562_Human | 0.97251316 |
75 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.97010180 |
76 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.95911564 |
77 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.95801233 |
78 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.95120818 |
79 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.94838047 |
80 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.92993304 |
81 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.92300724 |
82 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.91686802 |
83 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.91382270 |
84 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.90226301 |
85 | * FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.89569817 |
86 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.89555411 |
87 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.88515553 |
88 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.88340514 |
89 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.88213079 |
90 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.86461258 |
91 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.85695410 |
92 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.84209238 |
93 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.82558565 |
94 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.82061530 |
95 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.81508866 |
96 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.81499908 |
97 | * ATF3_27146783_Chip-Seq_COLON_Human | 0.80077927 |
98 | * CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.80052828 |
99 | * ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.79991329 |
100 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.78901911 |
101 | * FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.77331284 |
102 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.76234436 |
103 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.76109051 |
104 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.75678045 |
105 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.75529621 |
106 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.75184183 |
107 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.74391348 |
108 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.73655905 |
109 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.73619841 |
110 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.70712942 |
111 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.69799586 |
112 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.69735638 |
113 | * FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.66349703 |
114 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.64964053 |
115 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.64229588 |
116 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.64229588 |
117 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.63336035 |
118 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.62920986 |
119 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.62039775 |
120 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.60096329 |
121 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.58307425 |
122 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.57928497 |
123 | * FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.57884328 |
124 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.57794655 |
125 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.57059831 |
126 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.56825685 |
127 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.56489482 |
128 | * RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.55623183 |
129 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.54985089 |
130 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.54516036 |
131 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.53992284 |
132 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.53296512 |
133 | AR_20517297_ChIP-Seq_VCAP_Human | 0.52543088 |
134 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.52278698 |
135 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.51631049 |
136 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.51609807 |
137 | * TP63_22573176_ChIP-Seq_HFKS_Human | 0.47976409 |
138 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.47650974 |
139 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.47395406 |
140 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.47277830 |
141 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.46246335 |
142 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.46141659 |
143 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.45949305 |
144 | * CREB1_26743006_Chip-Seq_LNCaP_Human | 0.44868771 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 7.17304962 |
2 | MP0005360_urolithiasis | 6.51574972 |
3 | MP0005085_abnormal_gallbladder_physiolo | 5.78282723 |
4 | MP0005365_abnormal_bile_salt | 5.50270353 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 4.40526121 |
6 | MP0003806_abnormal_nucleotide_metabolis | 3.59438822 |
7 | MP0003252_abnormal_bile_duct | 3.36899251 |
8 | MP0010329_abnormal_lipoprotein_level | 3.12166429 |
9 | MP0009840_abnormal_foam_cell | 3.10247744 |
10 | MP0005083_abnormal_biliary_tract | 3.08519003 |
11 | MP0001666_abnormal_nutrient_absorption | 2.92767329 |
12 | MP0005332_abnormal_amino_acid | 2.53325322 |
13 | MP0003195_calcinosis | 2.47640630 |
14 | MP0002796_impaired_skin_barrier | 2.47012142 |
15 | MP0004019_abnormal_vitamin_homeostasis | 2.43225863 |
16 | MP0009780_abnormal_chondrocyte_physiolo | 2.19632810 |
17 | MP0003191_abnormal_cellular_cholesterol | 2.15210617 |
18 | MP0010234_abnormal_vibrissa_follicle | 2.08842938 |
19 | MP0000537_abnormal_urethra_morphology | 2.05421774 |
20 | MP0005076_abnormal_cell_differentiation | 2.00540765 |
21 | MP0002138_abnormal_hepatobiliary_system | 2.00138350 |
22 | MP0003705_abnormal_hypodermis_morpholog | 1.96873287 |
23 | MP0002254_reproductive_system_inflammat | 1.95393631 |
24 | MP0000609_abnormal_liver_physiology | 1.92095164 |
25 | MP0002118_abnormal_lipid_homeostasis | 1.86329120 |
26 | MP0005451_abnormal_body_composition | 1.86050763 |
27 | MP0003693_abnormal_embryo_hatching | 1.69114467 |
28 | MP0005409_darkened_coat_color | 1.65264732 |
29 | MP0000678_abnormal_parathyroid_gland | 1.60779283 |
30 | MP0003868_abnormal_feces_composition | 1.60122109 |
31 | MP0005319_abnormal_enzyme/_coenzyme | 1.57019159 |
32 | MP0000579_abnormal_nail_morphology | 1.54990010 |
33 | MP0001849_ear_inflammation | 1.52240276 |
34 | MP0010352_gastrointestinal_tract_polyps | 1.46947909 |
35 | MP0003878_abnormal_ear_physiology | 1.39233271 |
36 | MP0005377_hearing/vestibular/ear_phenot | 1.39233271 |
37 | MP0003011_delayed_dark_adaptation | 1.38522491 |
38 | MP0005501_abnormal_skin_physiology | 1.38342234 |
39 | MP0002249_abnormal_larynx_morphology | 1.37875191 |
40 | MP0009643_abnormal_urine_homeostasis | 1.37716959 |
41 | MP0001764_abnormal_homeostasis | 1.33117605 |
42 | MP0004381_abnormal_hair_follicle | 1.32600100 |
43 | MP0002098_abnormal_vibrissa_morphology | 1.29055873 |
44 | MP0002060_abnormal_skin_morphology | 1.26641410 |
45 | MP0004957_abnormal_blastocyst_morpholog | 1.24064083 |
46 | MP0003186_abnormal_redox_activity | 1.18030278 |
47 | MP0004233_abnormal_muscle_weight | 1.17094905 |
48 | MP0003453_abnormal_keratinocyte_physiol | 1.16654017 |
49 | MP0001216_abnormal_epidermal_layer | 1.16285132 |
50 | MP0005275_abnormal_skin_tensile | 1.15432084 |
51 | MP0010030_abnormal_orbit_morphology | 1.15356005 |
52 | MP0003123_paternal_imprinting | 1.15289548 |
53 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.14321039 |
54 | MP0000462_abnormal_digestive_system | 1.12589959 |
55 | MP0002089_abnormal_postnatal_growth/wei | 1.10694397 |
56 | MP0010678_abnormal_skin_adnexa | 1.10011615 |
57 | MP0009053_abnormal_anal_canal | 1.06478247 |
58 | MP0000377_abnormal_hair_follicle | 1.05679162 |
59 | MP0000647_abnormal_sebaceous_gland | 1.05303368 |
60 | MP0009697_abnormal_copulation | 1.04660869 |
61 | MP0001873_stomach_inflammation | 1.04090440 |
62 | MP0000383_abnormal_hair_follicle | 1.02862247 |
63 | MP0005647_abnormal_sex_gland | 1.02123118 |
64 | MP0005220_abnormal_exocrine_pancreas | 1.01770847 |
65 | MP0003315_abnormal_perineum_morphology | 1.00590403 |
66 | MP0004264_abnormal_extraembryonic_tissu | 0.99595602 |
67 | MP0004858_abnormal_nervous_system | 0.99555963 |
68 | MP0000598_abnormal_liver_morphology | 0.99481274 |
69 | MP0005636_abnormal_mineral_homeostasis | 0.98224641 |
70 | MP0004782_abnormal_surfactant_physiolog | 0.97786322 |
71 | MP0005408_hypopigmentation | 0.92765232 |
72 | MP0003936_abnormal_reproductive_system | 0.88447846 |
73 | MP0001756_abnormal_urination | 0.87475130 |
74 | MP0000566_synostosis | 0.87214144 |
75 | MP0000427_abnormal_hair_cycle | 0.86267745 |
76 | MP0000470_abnormal_stomach_morphology | 0.84411993 |
77 | MP0003718_maternal_effect | 0.83947865 |
78 | MP0005084_abnormal_gallbladder_morpholo | 0.82509651 |
79 | MP0001730_embryonic_growth_arrest | 0.81510977 |
80 | MP0000467_abnormal_esophagus_morphology | 0.80450603 |
81 | MP0003656_abnormal_erythrocyte_physiolo | 0.79983921 |
82 | MP0001727_abnormal_embryo_implantation | 0.79193449 |
83 | MP0004947_skin_inflammation | 0.79140017 |
84 | MP0002697_abnormal_eye_size | 0.78675464 |
85 | MP0002086_abnormal_extraembryonic_tissu | 0.78663700 |
86 | MP0003942_abnormal_urinary_system | 0.78352444 |
87 | MP0000477_abnormal_intestine_morphology | 0.77121265 |
88 | MP0010771_integument_phenotype | 0.76967573 |
89 | MP0001672_abnormal_embryogenesis/_devel | 0.76172547 |
90 | MP0005380_embryogenesis_phenotype | 0.76172547 |
91 | MP0002111_abnormal_tail_morphology | 0.76128452 |
92 | MP0010368_abnormal_lymphatic_system | 0.76022981 |
93 | MP0001765_abnormal_ion_homeostasis | 0.75464094 |
94 | MP0002909_abnormal_adrenal_gland | 0.75320604 |
95 | MP0009764_decreased_sensitivity_to | 0.74781683 |
96 | MP0009763_increased_sensitivity_to | 0.74775902 |
97 | MP0002088_abnormal_embryonic_growth/wei | 0.74548416 |
98 | MP0003984_embryonic_growth_retardation | 0.73943243 |
99 | MP0009642_abnormal_blood_homeostasis | 0.71538719 |
100 | MP0003115_abnormal_respiratory_system | 0.71244427 |
101 | MP0001243_abnormal_dermal_layer | 0.70472097 |
102 | MP0003941_abnormal_skin_development | 0.68960050 |
103 | MP0001661_extended_life_span | 0.68309727 |
104 | MP0008469_abnormal_protein_level | 0.68177286 |
105 | MP0004197_abnormal_fetal_growth/weight/ | 0.66423318 |
106 | MP0009379_abnormal_foot_pigmentation | 0.65621237 |
107 | MP0000604_amyloidosis | 0.65179061 |
108 | MP0001919_abnormal_reproductive_system | 0.64559554 |
109 | MP0000003_abnormal_adipose_tissue | 0.64516275 |
110 | MP0002136_abnormal_kidney_physiology | 0.64375676 |
111 | MP0001340_abnormal_eyelid_morphology | 0.64174873 |
112 | MP0009931_abnormal_skin_appearance | 0.64163213 |
113 | MP0002085_abnormal_embryonic_tissue | 0.63831930 |
114 | MP0002080_prenatal_lethality | 0.63247025 |
115 | MP0009765_abnormal_xenobiotic_induced | 0.61639735 |
116 | MP0009703_decreased_birth_body | 0.59588960 |
117 | MP0005395_other_phenotype | 0.59154123 |
118 | MP0000367_abnormal_coat/_hair | 0.59014472 |
119 | MP0004185_abnormal_adipocyte_glucose | 0.58957757 |
120 | MP0006036_abnormal_mitochondrial_physio | 0.58566226 |
121 | MP0005248_abnormal_Harderian_gland | 0.58372510 |
122 | MP0002971_abnormal_brown_adipose | 0.57971420 |
123 | MP0001881_abnormal_mammary_gland | 0.57534931 |
124 | MP0009384_cardiac_valve_regurgitation | 0.57026717 |
125 | MP0002078_abnormal_glucose_homeostasis | 0.54164277 |
126 | MP0001191_abnormal_skin_condition | 0.53333881 |
127 | MP0005376_homeostasis/metabolism_phenot | 0.53328184 |
128 | MP0005023_abnormal_wound_healing | 0.53165065 |
129 | MP0005334_abnormal_fat_pad | 0.52844353 |
130 | MP0002132_abnormal_respiratory_system | 0.50997566 |
131 | MP0003638_abnormal_response/metabolism_ | 0.50889241 |
132 | MP0001346_abnormal_lacrimal_gland | 0.49840898 |
133 | MP0005666_abnormal_adipose_tissue | 0.46788087 |
134 | MP0002876_abnormal_thyroid_physiology | 0.45939635 |
135 | MP0003566_abnormal_cell_adhesion | 0.44615866 |
136 | MP0005670_abnormal_white_adipose | 0.42325305 |
137 | MP0000627_abnormal_mammary_gland | 0.40162682 |
138 | MP0009672_abnormal_birth_weight | 0.39181269 |
139 | MP0005266_abnormal_metabolism | 0.39089739 |
140 | MP0005448_abnormal_energy_balance | 0.38366001 |
141 | MP0000762_abnormal_tongue_morphology | 0.38298343 |
142 | MP0004130_abnormal_muscle_cell | 0.37860663 |
143 | MP0000538_abnormal_urinary_bladder | 0.36581283 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Intrahepatic cholestasis (HP:0001406) | 6.82691452 |
2 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 6.70129547 |
3 | Deep venous thrombosis (HP:0002625) | 6.44298667 |
4 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 6.33426820 |
5 | Xanthomatosis (HP:0000991) | 6.00848561 |
6 | Prolonged partial thromboplastin time (HP:0003645) | 5.71901396 |
7 | Hypobetalipoproteinemia (HP:0003563) | 5.68692681 |
8 | Hyperlipoproteinemia (HP:0010980) | 5.04536810 |
9 | Hyperglycinemia (HP:0002154) | 4.83147290 |
10 | Complement deficiency (HP:0004431) | 4.63516646 |
11 | Hyperglycinuria (HP:0003108) | 4.51206159 |
12 | Pili torti (HP:0003777) | 4.45147034 |
13 | Hypolipoproteinemia (HP:0010981) | 4.41217150 |
14 | Hyperammonemia (HP:0001987) | 4.31632446 |
15 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.29162218 |
16 | Abnormality of glycine metabolism (HP:0010895) | 4.29162218 |
17 | Septate vagina (HP:0001153) | 4.25460161 |
18 | Epidermoid cyst (HP:0200040) | 4.06419451 |
19 | Fat malabsorption (HP:0002630) | 4.03624260 |
20 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 4.01577849 |
21 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 4.01419009 |
22 | Abnormality of the common coagulation pathway (HP:0010990) | 3.98787642 |
23 | Hypoalphalipoproteinemia (HP:0003233) | 3.98363460 |
24 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 3.95588157 |
25 | Joint hemorrhage (HP:0005261) | 3.94410220 |
26 | Ketosis (HP:0001946) | 3.85241476 |
27 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 3.76885125 |
28 | Abnormality of methionine metabolism (HP:0010901) | 3.72507885 |
29 | Hypoglycemic coma (HP:0001325) | 3.64503721 |
30 | Lip pit (HP:0100267) | 3.64273801 |
31 | Flat acetabular roof (HP:0003180) | 3.52953130 |
32 | Abnormality of complement system (HP:0005339) | 3.49078832 |
33 | Gout (HP:0001997) | 3.48089477 |
34 | Abnormality of the intrinsic pathway (HP:0010989) | 3.43887362 |
35 | Conjugated hyperbilirubinemia (HP:0002908) | 3.43124679 |
36 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.37560703 |
37 | Asymmetry of the thorax (HP:0001555) | 3.21742707 |
38 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.18851778 |
39 | Hypercholesterolemia (HP:0003124) | 3.12498492 |
40 | Abnormality of serum amino acid levels (HP:0003112) | 3.12250950 |
41 | Abnormality of nucleobase metabolism (HP:0010932) | 3.10906963 |
42 | Steatorrhea (HP:0002570) | 3.08497619 |
43 | Amelogenesis imperfecta (HP:0000705) | 3.01175435 |
44 | Hypotrichosis (HP:0001006) | 3.01009601 |
45 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.00402448 |
46 | Abnormality of purine metabolism (HP:0004352) | 2.97580093 |
47 | Delayed CNS myelination (HP:0002188) | 2.91251877 |
48 | Fragile nails (HP:0001808) | 2.90866368 |
49 | Sparse lateral eyebrow (HP:0005338) | 2.88824185 |
50 | Myocardial infarction (HP:0001658) | 2.88164427 |
51 | Malnutrition (HP:0004395) | 2.88019882 |
52 | Vascular calcification (HP:0004934) | 2.84066436 |
53 | Pterygium (HP:0001059) | 2.82042911 |
54 | Palmoplantar hyperkeratosis (HP:0000972) | 2.80009473 |
55 | Hyperbilirubinemia (HP:0002904) | 2.79331359 |
56 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.79202686 |
57 | Advanced eruption of teeth (HP:0006288) | 2.78558398 |
58 | Ketoacidosis (HP:0001993) | 2.77617738 |
59 | Curly hair (HP:0002212) | 2.72680210 |
60 | Spontaneous abortion (HP:0005268) | 2.70340363 |
61 | Dicarboxylic aciduria (HP:0003215) | 2.69946514 |
62 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.69946514 |
63 | Right ventricular cardiomyopathy (HP:0011663) | 2.66793456 |
64 | Hepatocellular carcinoma (HP:0001402) | 2.66452906 |
65 | Concave nail (HP:0001598) | 2.64418961 |
66 | Lethargy (HP:0001254) | 2.61788773 |
67 | Germ cell neoplasia (HP:0100728) | 2.59677740 |
68 | Palmar hyperkeratosis (HP:0010765) | 2.59528684 |
69 | Sparse eyelashes (HP:0000653) | 2.56175678 |
70 | Abnormality of the salivary glands (HP:0010286) | 2.55802077 |
71 | Metabolic acidosis (HP:0001942) | 2.53909087 |
72 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.53785405 |
73 | Milia (HP:0001056) | 2.50863946 |
74 | Thin bony cortex (HP:0002753) | 2.50260253 |
75 | J-shaped sella turcica (HP:0002680) | 2.49693261 |
76 | Cardiovascular calcification (HP:0011915) | 2.49448728 |
77 | Abnormality of the gastric mucosa (HP:0004295) | 2.43542246 |
78 | Esophageal varix (HP:0002040) | 2.36604950 |
79 | Hyperactive renin-angiotensin system (HP:0000841) | 2.34720952 |
80 | Spastic diplegia (HP:0001264) | 2.33919334 |
81 | Irritability (HP:0000737) | 2.27117291 |
82 | Absent eyelashes (HP:0000561) | 2.25817586 |
83 | Hypochromic microcytic anemia (HP:0004840) | 2.24929602 |
84 | Nail dystrophy (HP:0008404) | 2.24557483 |
85 | Abdominal distention (HP:0003270) | 2.23128329 |
86 | Micronodular cirrhosis (HP:0001413) | 2.22568514 |
87 | Skin nodule (HP:0200036) | 2.22272035 |
88 | Neonatal onset (HP:0003623) | 2.20680530 |
89 | Increased purine levels (HP:0004368) | 2.19446833 |
90 | Hyperuricemia (HP:0002149) | 2.19446833 |
91 | Selective tooth agenesis (HP:0001592) | 2.19172106 |
92 | Popliteal pterygium (HP:0009756) | 2.18765285 |
93 | Abnormality of the dental root (HP:0006486) | 2.18480610 |
94 | Taurodontia (HP:0000679) | 2.18480610 |
95 | Abnormality of permanent molar morphology (HP:0011071) | 2.18480610 |
96 | Systemic lupus erythematosus (HP:0002725) | 2.17666888 |
97 | Hypoplasia of dental enamel (HP:0006297) | 2.13515720 |
98 | Brushfield spots (HP:0001088) | 2.13447889 |
99 | Rickets (HP:0002748) | 2.12996784 |
100 | Cerebral edema (HP:0002181) | 2.11109389 |
101 | Pancreatitis (HP:0001733) | 2.10575625 |
102 | Hypoglycemic seizures (HP:0002173) | 2.09689197 |
103 | Abnormal cartilage morphology (HP:0002763) | 2.09091668 |
104 | Glomerulonephritis (HP:0000099) | 2.08868474 |
105 | Alopecia of scalp (HP:0002293) | 2.08582093 |
106 | Late onset (HP:0003584) | 2.08276018 |
107 | Testicular atrophy (HP:0000029) | 2.04399933 |
108 | Hyperglycemia (HP:0003074) | 2.04334911 |
109 | Generalized aminoaciduria (HP:0002909) | 2.03870238 |
110 | Acanthocytosis (HP:0001927) | 2.03664220 |
111 | Thick nail (HP:0001805) | 2.03206095 |
112 | Ridged nail (HP:0001807) | 2.02967598 |
113 | Abnormality of the lacrimal duct (HP:0011481) | 2.02356664 |
114 | Plantar hyperkeratosis (HP:0007556) | 1.99343950 |
115 | Abnormal tarsal ossification (HP:0008369) | 1.97831852 |
116 | Onycholysis (HP:0001806) | 1.97298355 |
117 | Breast carcinoma (HP:0003002) | 1.95617451 |
118 | Amyloidosis (HP:0011034) | 1.95327725 |
119 | Abnormality of the dental pulp (HP:0006479) | 1.94639918 |
120 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.94506478 |
121 | Chronic bronchitis (HP:0004469) | 1.93313880 |
122 | Abnormal gallbladder morphology (HP:0012437) | 1.93086080 |
123 | Vomiting (HP:0002013) | 1.92117778 |
124 | Nasolacrimal duct obstruction (HP:0000579) | 1.91972211 |
125 | Bronchomalacia (HP:0002780) | 1.91529126 |
126 | Abnormality of molar morphology (HP:0011070) | 1.91175949 |
127 | Abnormality of molar (HP:0011077) | 1.91175949 |
128 | Menorrhagia (HP:0000132) | 1.90454138 |
129 | Bifid scrotum (HP:0000048) | 1.89937882 |
130 | Distal lower limb muscle weakness (HP:0009053) | 1.89066953 |
131 | Hypophosphatemic rickets (HP:0004912) | 1.88984916 |
132 | Broad face (HP:0000283) | 1.88681289 |
133 | Woolly hair (HP:0002224) | 1.88623647 |
134 | Cholelithiasis (HP:0001081) | 1.88537736 |
135 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.87003461 |
136 | Alkalosis (HP:0001948) | 1.86772218 |
137 | Abnormality of nail color (HP:0100643) | 1.85152398 |
138 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.83742013 |
139 | Spinal cord compression (HP:0002176) | 1.83372188 |
140 | Abnormality of iron homeostasis (HP:0011031) | 1.82955673 |
141 | Proximal tubulopathy (HP:0000114) | 1.82678448 |
142 | Hemorrhage of the eye (HP:0011885) | 1.82521887 |
143 | Hydroxyprolinuria (HP:0003080) | 1.82512382 |
144 | Abnormality of proline metabolism (HP:0010907) | 1.82512382 |
145 | Opisthotonus (HP:0002179) | 1.81905196 |
146 | Abnormal hemoglobin (HP:0011902) | 1.81668812 |
147 | Abnormality of urine glucose concentration (HP:0011016) | 1.81227706 |
148 | Glycosuria (HP:0003076) | 1.81227706 |
149 | Enlarged kidneys (HP:0000105) | 1.80932565 |
150 | Natal tooth (HP:0000695) | 1.80354639 |
151 | Abnormality of the nasal septum (HP:0000419) | 1.80340335 |
152 | Gingival bleeding (HP:0000225) | 1.80255686 |
153 | Hypoparathyroidism (HP:0000829) | 1.80076901 |
154 | Abnormal hair laboratory examination (HP:0003328) | 1.77615545 |
155 | Deviation of the thumb (HP:0009603) | 1.77465582 |
156 | Hyperacusis (HP:0010780) | 1.77211831 |
157 | Mitral stenosis (HP:0001718) | 1.76368600 |
158 | Microglossia (HP:0000171) | 1.71691028 |
159 | Seborrheic dermatitis (HP:0001051) | 1.71126072 |
160 | Trismus (HP:0000211) | 1.70850122 |
161 | Lymphangioma (HP:0100764) | 1.69372142 |
162 | Widely patent fontanelles and sutures (HP:0004492) | 1.68574692 |
163 | Anal stenosis (HP:0002025) | 1.68052331 |
164 | Short nail (HP:0001799) | 1.67353008 |
165 | Depressed nasal tip (HP:0000437) | 1.65634413 |
166 | Blepharitis (HP:0000498) | 1.63513134 |
167 | Abnormality of carpal bone ossification (HP:0006257) | 1.61888374 |
168 | Oligodontia (HP:0000677) | 1.57183459 |
169 | Abnormality of secondary sexual hair (HP:0009888) | 1.56850720 |
170 | Abnormality of the axillary hair (HP:0100134) | 1.56850720 |
171 | Neonatal death (HP:0003811) | 1.56334853 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCKDK | 5.69360051 |
2 | ERN1 | 4.17748189 |
3 | MST1R | 4.10341533 |
4 | FGFR4 | 3.83310985 |
5 | SIK1 | 3.59472872 |
6 | EPHA2 | 3.17649675 |
7 | SMG1 | 3.17290711 |
8 | LATS1 | 2.85450427 |
9 | EEF2K | 2.55967779 |
10 | CDK12 | 2.25602331 |
11 | MAP3K3 | 2.10854767 |
12 | TAOK3 | 2.04263686 |
13 | INSRR | 1.97719529 |
14 | ERBB4 | 1.94569178 |
15 | ICK | 1.89012867 |
16 | FRK | 1.86357947 |
17 | SCYL2 | 1.85842330 |
18 | TRIB3 | 1.79396953 |
19 | PTK6 | 1.73500651 |
20 | PIK3CG | 1.72818187 |
21 | MET | 1.72566850 |
22 | PAK4 | 1.62796602 |
23 | TESK1 | 1.51921121 |
24 | FER | 1.45825689 |
25 | MAPK11 | 1.43775720 |
26 | IRAK3 | 1.41568481 |
27 | AKT3 | 1.40934505 |
28 | STK38L | 1.40861010 |
29 | MAPKAPK3 | 1.38824096 |
30 | TYK2 | 1.38580757 |
31 | NEK9 | 1.37984964 |
32 | MAP2K2 | 1.36710537 |
33 | PIK3CA | 1.36171440 |
34 | NME2 | 1.35806283 |
35 | MAP3K9 | 1.35398683 |
36 | MUSK | 1.35010686 |
37 | MAPK15 | 1.33827983 |
38 | NEK6 | 1.32789745 |
39 | RPS6KB2 | 1.28182673 |
40 | PKN2 | 1.27341587 |
41 | NME1 | 1.27074024 |
42 | CDK7 | 1.22563692 |
43 | FGFR2 | 1.22178210 |
44 | EPHB2 | 1.11715154 |
45 | LMTK2 | 1.11629646 |
46 | ERBB2 | 1.10068193 |
47 | CDK6 | 1.05543012 |
48 | DYRK1B | 1.00308179 |
49 | MST4 | 0.99376116 |
50 | EPHA3 | 0.97587438 |
51 | ABL2 | 0.95084997 |
52 | FLT3 | 0.94503444 |
53 | STK39 | 0.92915038 |
54 | MAP3K11 | 0.92690996 |
55 | MAP3K2 | 0.88050342 |
56 | EPHB1 | 0.86385126 |
57 | PTK2 | 0.86155808 |
58 | MAP3K12 | 0.86148377 |
59 | PDK3 | 0.83981616 |
60 | PDK4 | 0.83981616 |
61 | MAP3K7 | 0.82951881 |
62 | CAMK1G | 0.82651753 |
63 | MAP2K4 | 0.82173881 |
64 | EIF2AK1 | 0.82110491 |
65 | PRKAA2 | 0.81646220 |
66 | MAP3K10 | 0.81384370 |
67 | JAK2 | 0.79348901 |
68 | RPS6KA2 | 0.79280307 |
69 | STK3 | 0.78173590 |
70 | VRK2 | 0.78122160 |
71 | TAOK1 | 0.77864653 |
72 | LRRK2 | 0.75704406 |
73 | CHUK | 0.75477597 |
74 | ILK | 0.74618527 |
75 | MAP2K6 | 0.74446339 |
76 | MAP2K3 | 0.74083255 |
77 | PINK1 | 0.73048830 |
78 | KDR | 0.71459295 |
79 | NUAK1 | 0.67976597 |
80 | GSK3A | 0.66311205 |
81 | MAP3K6 | 0.65836119 |
82 | PRKD3 | 0.65194623 |
83 | PDGFRA | 0.64803141 |
84 | MAP2K1 | 0.63936205 |
85 | RIPK1 | 0.63095578 |
86 | GRK1 | 0.62737144 |
87 | TESK2 | 0.61214560 |
88 | STK10 | 0.59264542 |
89 | PRKCI | 0.58591013 |
90 | MAPK4 | 0.55290496 |
91 | MTOR | 0.54226325 |
92 | TSSK6 | 0.54137268 |
93 | RPS6KB1 | 0.53364577 |
94 | LATS2 | 0.52902803 |
95 | CDK4 | 0.52530747 |
96 | TAF1 | 0.51923429 |
97 | RET | 0.51556986 |
98 | TGFBR2 | 0.49741856 |
99 | PIM2 | 0.49490569 |
100 | PDK2 | 0.47624371 |
101 | RPS6KA4 | 0.47415354 |
102 | PRKCZ | 0.47232386 |
103 | TBK1 | 0.46364098 |
104 | CAMK2G | 0.45324897 |
105 | JAK1 | 0.44522508 |
106 | PRKAA1 | 0.44031203 |
107 | DYRK3 | 0.43662591 |
108 | DMPK | 0.42065407 |
109 | FGFR3 | 0.41086417 |
110 | GRK6 | 0.41051697 |
111 | PBK | 0.40471674 |
112 | BMX | 0.40470781 |
113 | AURKB | 0.39453695 |
114 | CSNK1G1 | 0.39216758 |
115 | MAPKAPK2 | 0.39132498 |
116 | TTK | 0.38484202 |
117 | FGFR1 | 0.38434859 |
118 | WNK4 | 0.38336099 |
119 | PRKACG | 0.38196045 |
120 | AKT2 | 0.37890454 |
121 | BRSK2 | 0.37741376 |
122 | BUB1 | 0.37672787 |
123 | ACVR1B | 0.36670555 |
124 | MAP3K8 | 0.36190595 |
125 | NLK | 0.36088162 |
126 | DAPK2 | 0.35759536 |
127 | RPS6KA1 | 0.35701801 |
128 | CSK | 0.35085283 |
129 | AURKA | 0.34380531 |
130 | RPS6KC1 | 0.33258251 |
131 | RPS6KL1 | 0.33258251 |
132 | MAP3K1 | 0.30714337 |
133 | PRKD2 | 0.29733605 |
134 | CAMK1D | 0.29478083 |
135 | MAP3K14 | 0.29416810 |
136 | MAP3K5 | 0.29088625 |
137 | IRAK1 | 0.28482804 |
138 | CSNK1E | 0.28203274 |
139 | PRKG2 | 0.27882742 |
140 | BRD4 | 0.27846662 |
141 | MELK | 0.26998276 |
142 | STK24 | 0.26842630 |
143 | STK38 | 0.26711067 |
144 | SIK3 | 0.26167820 |
145 | PDPK1 | 0.25906592 |
146 | TIE1 | 0.25855317 |
147 | PAK2 | 0.24887758 |
148 | SRPK1 | 0.24228886 |
149 | CHEK1 | 0.23338406 |
150 | BRSK1 | 0.22952085 |
151 | MAPK8 | 0.22926575 |
152 | IRAK2 | 0.22558178 |
153 | RPS6KA6 | 0.20725442 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 4.12693029 |
2 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.28855320 |
3 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.16156634 |
4 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.87823778 |
5 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.76608176 |
6 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.69869145 |
7 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.69011307 |
8 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.59248691 |
9 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.47556479 |
10 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.45011340 |
11 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.37189057 |
12 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.33892602 |
13 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.29690372 |
14 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.20649493 |
15 | Histidine metabolism_Homo sapiens_hsa00340 | 2.10375747 |
16 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.06077745 |
17 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.02429346 |
18 | Peroxisome_Homo sapiens_hsa04146 | 2.00315314 |
19 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.99449827 |
20 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.83043606 |
21 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.82335558 |
22 | Retinol metabolism_Homo sapiens_hsa00830 | 1.82097521 |
23 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.80294679 |
24 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.79678042 |
25 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.79265341 |
26 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.78765737 |
27 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.78080630 |
28 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.72573651 |
29 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.63950220 |
30 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.62684035 |
31 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.62277269 |
32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.61073302 |
33 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.55788618 |
34 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.53284097 |
35 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.52150221 |
36 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.49184169 |
37 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.49015153 |
38 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.44663637 |
39 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.42854351 |
40 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.42254592 |
41 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.38005890 |
42 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.35620587 |
43 | Bile secretion_Homo sapiens_hsa04976 | 1.34524017 |
44 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.30357668 |
45 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.30199332 |
46 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.23060981 |
47 | Tight junction_Homo sapiens_hsa04530 | 1.21747095 |
48 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.21664907 |
49 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.19421718 |
50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.17912776 |
51 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.16966698 |
52 | Sulfur relay system_Homo sapiens_hsa04122 | 1.14303525 |
53 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.12548644 |
54 | ABC transporters_Homo sapiens_hsa02010 | 1.12384614 |
55 | Carbon metabolism_Homo sapiens_hsa01200 | 1.11011147 |
56 | Endometrial cancer_Homo sapiens_hsa05213 | 1.02180854 |
57 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.00519032 |
58 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.94114379 |
59 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.93469112 |
60 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.86870238 |
61 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.84479128 |
62 | Adherens junction_Homo sapiens_hsa04520 | 0.84035000 |
63 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.78928687 |
64 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.78690302 |
65 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.78049856 |
66 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.77457139 |
67 | Lysine degradation_Homo sapiens_hsa00310 | 0.75001470 |
68 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.71856682 |
69 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.70108367 |
70 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.70058031 |
71 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.69858769 |
72 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.68546884 |
73 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.67807372 |
74 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.67558794 |
75 | Prostate cancer_Homo sapiens_hsa05215 | 0.66782440 |
76 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.66061165 |
77 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.65672339 |
78 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.61495691 |
79 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.59410873 |
80 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.59145078 |
81 | Other glycan degradation_Homo sapiens_hsa00511 | 0.58125382 |
82 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.56292278 |
83 | Metabolic pathways_Homo sapiens_hsa01100 | 0.52004190 |
84 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.51036488 |
85 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.50483155 |
86 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.47308782 |
87 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.46267595 |
88 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.45899698 |
89 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.44966879 |
90 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.44635871 |
91 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.41543504 |
92 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.39752601 |
93 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.39208899 |
94 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.37833860 |
95 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.37016661 |
96 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.36204987 |
97 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.35688324 |
98 | Galactose metabolism_Homo sapiens_hsa00052 | 0.31833141 |
99 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.30974726 |
100 | Insulin resistance_Homo sapiens_hsa04931 | 0.22740390 |
101 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.21705383 |
102 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.19302972 |
103 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.18206288 |
104 | Prion diseases_Homo sapiens_hsa05020 | 0.17431133 |
105 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.15238015 |
106 | Mineral absorption_Homo sapiens_hsa04978 | 0.04954952 |
107 | Bladder cancer_Homo sapiens_hsa05219 | 0.04381134 |
108 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.02093001 |
109 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.01609595 |
110 | Thyroid cancer_Homo sapiens_hsa05216 | -0.1797792 |
111 | Pancreatic secretion_Homo sapiens_hsa04972 | -0.1741280 |
112 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.1732511 |
113 | Sphingolipid metabolism_Homo sapiens_hsa00600 | -0.1663098 |
114 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.1448140 |
115 | Amoebiasis_Homo sapiens_hsa05146 | -0.1443716 |
116 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.1344382 |
117 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | -0.1190419 |
118 | Pyrimidine metabolism_Homo sapiens_hsa00240 | -0.0992718 |
119 | Hepatitis C_Homo sapiens_hsa05160 | -0.0551532 |
120 | Ether lipid metabolism_Homo sapiens_hsa00565 | -0.0489800 |
121 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | -0.0367841 |
122 | Ribosome_Homo sapiens_hsa03010 | -0.0351155 |
123 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | -0.0172220 |
124 | Renin-angiotensin system_Homo sapiens_hsa04614 | -0.0097360 |
125 | Glucagon signaling pathway_Homo sapiens_hsa04922 | -0.0091786 |