ESRRA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)5.30729359
2sarcomere organization (GO:0045214)5.16356838
3carnitine shuttle (GO:0006853)5.07429861
4lysine metabolic process (GO:0006553)4.86624508
5lysine catabolic process (GO:0006554)4.86624508
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.75547992
7fatty acid transmembrane transport (GO:1902001)4.69746799
82-oxoglutarate metabolic process (GO:0006103)4.54746880
9NADH metabolic process (GO:0006734)4.54234914
10fatty acid beta-oxidation (GO:0006635)4.25977550
11bundle of His cell to Purkinje myocyte communication (GO:0086069)4.25811623
12carnitine transport (GO:0015879)4.22613724
13amino-acid betaine transport (GO:0015838)4.22613724
14cardiac myofibril assembly (GO:0055003)4.20868277
15negative regulation of potassium ion transmembrane transport (GO:1901380)4.19404398
16carnitine transmembrane transport (GO:1902603)4.13717884
17plasma membrane repair (GO:0001778)4.01674738
18actin-myosin filament sliding (GO:0033275)3.94328483
19muscle filament sliding (GO:0030049)3.94328483
20aspartate family amino acid catabolic process (GO:0009068)3.93970537
21regulation of sequestering of triglyceride (GO:0010889)3.91408578
22cardiac muscle contraction (GO:0060048)3.89777582
23tricarboxylic acid metabolic process (GO:0072350)3.89295801
24fructose metabolic process (GO:0006000)3.87860191
25myofibril assembly (GO:0030239)3.87745682
26regulation of fatty acid oxidation (GO:0046320)3.80916464
27ventricular cardiac muscle cell action potential (GO:0086005)3.78495849
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.78463166
29skeletal muscle contraction (GO:0003009)3.72766777
30fatty acid oxidation (GO:0019395)3.70307075
31regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.68306901
32negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.66928072
33positive regulation of Cdc42 GTPase activity (GO:0043089)3.64380239
34lipid oxidation (GO:0034440)3.63706551
35regulation of skeletal muscle contraction (GO:0014819)3.63020772
36fatty acid catabolic process (GO:0009062)3.61845279
37quaternary ammonium group transport (GO:0015697)3.55038770
38acetyl-CoA metabolic process (GO:0006084)3.48814639
39regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.46408233
40succinate metabolic process (GO:0006105)3.45504887
41short-chain fatty acid metabolic process (GO:0046459)3.44419702
42urea cycle (GO:0000050)3.42892222
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.41590212
44carnitine metabolic process (GO:0009437)3.40977830
45oxaloacetate metabolic process (GO:0006107)3.39777701
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39432271
47valine metabolic process (GO:0006573)3.39027449
48cell communication involved in cardiac conduction (GO:0086065)3.37233252
49regulation of triglyceride catabolic process (GO:0010896)3.34209881
50angiotensin maturation (GO:0002003)3.33066835
51regulation of actin filament-based movement (GO:1903115)3.32338371
52negative regulation of erythrocyte differentiation (GO:0045647)3.30450808
53cellular ketone body metabolic process (GO:0046950)3.30202326
54actomyosin structure organization (GO:0031032)3.29534197
55regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.27272788
56regulation of acyl-CoA biosynthetic process (GO:0050812)3.25426505
57cardiac muscle cell development (GO:0055013)3.24807789
58actin-mediated cell contraction (GO:0070252)3.23664341
59desmosome organization (GO:0002934)3.22734358
60positive regulation of fatty acid oxidation (GO:0046321)3.21910016
61urea metabolic process (GO:0019627)3.21801700
62regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.21180855
63striated muscle contraction (GO:0006941)3.20671366
64amino-acid betaine metabolic process (GO:0006577)3.20332397
65creatine metabolic process (GO:0006600)3.19374747
66monocarboxylic acid catabolic process (GO:0072329)3.18247108
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.15991972
68proline biosynthetic process (GO:0006561)3.12105200
69glyoxylate metabolic process (GO:0046487)3.12032984
70nitrogen cycle metabolic process (GO:0071941)3.05944674
71regulation of fatty acid beta-oxidation (GO:0031998)3.04113710
72cardiac cell development (GO:0055006)3.03917688
73striated muscle atrophy (GO:0014891)3.03306321
74regulation of cofactor metabolic process (GO:0051193)3.01187590
75regulation of coenzyme metabolic process (GO:0051196)3.01187590
76protein localization to endosome (GO:0036010)3.00962821
77biotin metabolic process (GO:0006768)3.00876851
78Golgi transport vesicle coating (GO:0048200)2.98093539
79COPI coating of Golgi vesicle (GO:0048205)2.98093539
80cardiac muscle hypertrophy (GO:0003300)2.97139411
81negative regulation of necroptotic process (GO:0060546)2.97051034
82regulation of cholesterol homeostasis (GO:2000188)2.96884027
83triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.94755599
84focal adhesion assembly (GO:0048041)2.93965634
85cell-substrate adherens junction assembly (GO:0007045)2.93965634
86phospholipid homeostasis (GO:0055091)2.93915217
87dicarboxylic acid biosynthetic process (GO:0043650)2.93333701
88regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.93280784
89barbed-end actin filament capping (GO:0051016)2.92901240
90drug catabolic process (GO:0042737)2.90706634
91branched-chain amino acid metabolic process (GO:0009081)2.90183355
92flavonoid metabolic process (GO:0009812)2.89209814
93regulation of necrotic cell death (GO:0010939)2.87981548
94regulation of early endosome to late endosome transport (GO:2000641)2.87219442
95apoptotic process involved in morphogenesis (GO:0060561)2.86842786
96gluconeogenesis (GO:0006094)2.86678393
97regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.86347036
98sulfur amino acid catabolic process (GO:0000098)2.83932087
99pyrimidine ribonucleoside catabolic process (GO:0046133)2.83556226
100striated muscle hypertrophy (GO:0014897)2.82436886
101kynurenine metabolic process (GO:0070189)2.82194976
102ketone body metabolic process (GO:1902224)2.82147245
103cell communication by electrical coupling (GO:0010644)2.81966001
1044-hydroxyproline metabolic process (GO:0019471)2.81765589
105positive regulation of lipid catabolic process (GO:0050996)2.80679463
106branched-chain amino acid catabolic process (GO:0009083)2.80183580
107glucose 6-phosphate metabolic process (GO:0051156)2.79763913
108regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.79538368
109heart trabecula formation (GO:0060347)2.79436105
110epithelial cell-cell adhesion (GO:0090136)2.78329930
111glycosphingolipid catabolic process (GO:0046479)2.77401593
112positive regulation of triglyceride metabolic process (GO:0090208)2.75737642
113skeletal muscle adaptation (GO:0043501)2.75584065
114regulation of necroptotic process (GO:0060544)2.73967435
115antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.73540487
116pinocytosis (GO:0006907)2.73072681
117hexose biosynthetic process (GO:0019319)2.72994579
118positive regulation of lipid storage (GO:0010884)2.71712470
119cysteine metabolic process (GO:0006534)2.71510165
120monosaccharide biosynthetic process (GO:0046364)2.70524572
121response to mercury ion (GO:0046689)2.70493222
122low-density lipoprotein particle clearance (GO:0034383)2.70485412
123mannose metabolic process (GO:0006013)2.70402701
124antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70174681
125sarcoplasmic reticulum calcium ion transport (GO:0070296)2.70062179
126oxidative phosphorylation (GO:0006119)2.70015288
127regulation of the force of heart contraction (GO:0002026)2.69419171
128alpha-linolenic acid metabolic process (GO:0036109)2.69188026
129adult heart development (GO:0007512)2.68840109
130actin filament-based movement (GO:0030048)2.68779368
131activation of Rac GTPase activity (GO:0032863)2.68589154
132glucan catabolic process (GO:0009251)2.68163888
133negative regulation of cell size (GO:0045792)2.67933101
134adherens junction assembly (GO:0034333)2.65402387
135cellular modified amino acid catabolic process (GO:0042219)2.64895175
136erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.64014769
137positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.63978202
138epithelial cell differentiation involved in prostate gland development (GO:0060742)2.62070450
139glycolipid catabolic process (GO:0019377)2.59969294
140embryonic process involved in female pregnancy (GO:0060136)2.57428700
141positive regulation of lipoprotein lipase activity (GO:0051006)2.56984894
142positive regulation of triglyceride lipase activity (GO:0061365)2.56984894
143regulation of glucose import in response to insulin stimulus (GO:2001273)2.55576217
144antigen processing and presentation of endogenous antigen (GO:0019883)2.55295603
145retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54918115
146nucleoside diphosphate biosynthetic process (GO:0009133)2.54122654
147cell-substrate junction assembly (GO:0007044)2.53864499
148maternal placenta development (GO:0001893)2.49935167
149proline metabolic process (GO:0006560)2.49392885
150muscle atrophy (GO:0014889)2.49179479
151cellular polysaccharide catabolic process (GO:0044247)2.47801795
152negative regulation of myotube differentiation (GO:0010832)2.45348407
153GDP-mannose metabolic process (GO:0019673)2.44053830
154glycogen catabolic process (GO:0005980)2.43697534
155response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.42911563
156regulation of pseudopodium assembly (GO:0031272)2.42259603
157glutamine family amino acid biosynthetic process (GO:0009084)2.40362000
158pentose-phosphate shunt (GO:0006098)2.38684850
159epoxygenase P450 pathway (GO:0019373)2.35481130
160glucose catabolic process (GO:0006007)2.34834847
161endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.34092500
162regulation of fatty acid biosynthetic process (GO:0042304)2.33273910
1633-UTR-mediated mRNA stabilization (GO:0070935)2.32300144
164striated muscle adaptation (GO:0014888)2.31779569
165positive regulation of receptor recycling (GO:0001921)2.30648324
166regulation of cholesterol metabolic process (GO:0090181)2.28613033
167negative regulation of fatty acid transport (GO:2000192)2.27893232
168response to laminar fluid shear stress (GO:0034616)2.26258168
169protein-lipid complex assembly (GO:0065005)2.25434831
170modulation by symbiont of host cellular process (GO:0044068)2.24166267
171diacylglycerol metabolic process (GO:0046339)2.22340100
172cytoskeletal anchoring at plasma membrane (GO:0007016)2.21194277
173negative regulation of necrotic cell death (GO:0060547)2.21144108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.12897251
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.08423160
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.64707600
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.62398210
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.12051610
6* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.07686808
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.06638579
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.63016229
9ZNF263_19887448_ChIP-Seq_K562_Human2.58618551
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46649999
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.44024037
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.31395677
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.23244373
14* MYC_22102868_ChIP-Seq_BL_Human2.17028581
15LXR_22292898_ChIP-Seq_THP-1_Human2.07652211
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.04600445
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.00308216
18CLOCK_20551151_ChIP-Seq_293T_Human1.94132728
19TBX20_22328084_ChIP-Seq_HEART_Mouse1.91948666
20TBX20_22080862_ChIP-Seq_HEART_Mouse1.91948666
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78347029
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73041453
23* RACK7_27058665_Chip-Seq_MCF-7_Human1.71702919
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.68079186
25* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.61715795
26VDR_24763502_ChIP-Seq_THP-1_Human1.59730210
27CDX2_20551321_ChIP-Seq_CACO-2_Human1.56700794
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53215245
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52850353
30* ELK3_25401928_ChIP-Seq_HUVEC_Human1.51537502
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48910580
32* KDM2B_26808549_Chip-Seq_DND41_Human1.46755465
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45375022
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.44928770
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44339593
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43876927
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42175362
38ATF3_27146783_Chip-Seq_COLON_Human1.41703444
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40162601
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39437529
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.37357896
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35235769
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33642749
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32022023
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32017613
46CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28643322
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28114346
48GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26561090
49* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26466703
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.24810034
51P68_20966046_ChIP-Seq_HELA_Human1.24018202
52TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.23687021
53SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22268400
54RUNX1_27514584_Chip-Seq_MCF-7_Human1.22096323
55SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20450765
56BCOR_27268052_Chip-Seq_Bcells_Human1.19599397
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18002812
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17981305
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17689156
60TCF7_22412390_ChIP-Seq_EML_Mouse1.17537567
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17122467
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.16867217
63* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16822109
64NCOR1_26117541_ChIP-Seq_K562_Human1.16733617
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.15274231
66CREB1_26743006_Chip-Seq_LNCaP_Human1.15244147
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14981031
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13160754
69GATA6_25053715_ChIP-Seq_YYC3_Human1.12895635
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.12740957
71KDM2B_26808549_Chip-Seq_K562_Human1.12641395
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12592293
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12296217
74MAF_26560356_Chip-Seq_TH2_Human1.12273450
75SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11766910
76* TP63_22573176_ChIP-Seq_HFKS_Human1.10941215
77* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10449000
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10232877
79BCL6_27268052_Chip-Seq_Bcells_Human1.10079282
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09935998
81GATA1_19941826_ChIP-Seq_K562_Human1.09408396
82VDR_21846776_ChIP-Seq_THP-1_Human1.08263911
83UTX_26944678_Chip-Seq_JUKART_Human1.07769220
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07694941
85* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07619926
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07227211
87EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06062211
88SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05917877
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05547908
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05485574
91* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05015630
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04209060
93* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04016697
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03196862
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02743454
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02496319
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02388056
98CTCF_27219007_Chip-Seq_Bcells_Human1.02339742
99P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02324846
100* KDM2B_26808549_Chip-Seq_JURKAT_Human1.02270153
101GATA2_19941826_ChIP-Seq_K562_Human1.01566205
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01185030
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01176406
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00301018
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99894737
106GATA4_25053715_ChIP-Seq_YYC3_Human0.98989726
107HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98547948
108* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97723546
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96955339
110GATA1_19941827_ChIP-Seq_MEL_Mouse0.94997926
111SMC4_20622854_ChIP-Seq_HELA_Human0.94989820
112IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94395718
113EGR1_19032775_ChIP-ChIP_M12_Human0.93704983
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91717655
115* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90924295
116* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90722056
117* SA1_27219007_Chip-Seq_ERYTHROID_Human0.89751378
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89207036
119MAF_26560356_Chip-Seq_TH1_Human0.87550120
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.87012861
121TET1_21451524_ChIP-Seq_MESCs_Mouse0.86634705
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.86499518
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86460311
124CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86227850
125ELF1_20517297_ChIP-Seq_JURKAT_Human0.85309710
126* SA1_27219007_Chip-Seq_Bcells_Human0.84969220
127* HNF4A_19822575_ChIP-Seq_HepG2_Human0.84698452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.66524254
2MP0003646_muscle_fatigue4.34709625
3MP0005360_urolithiasis4.33195234
4MP0000751_myopathy3.57089245
5MP0004084_abnormal_cardiac_muscle3.46789612
6MP0002139_abnormal_hepatobiliary_system2.91732448
7MP0004130_abnormal_muscle_cell2.83628593
8MP0005330_cardiomyopathy2.78197140
9MP0004215_abnormal_myocardial_fiber2.77976282
10MP0004036_abnormal_muscle_relaxation2.70778013
11MP0000749_muscle_degeneration2.57345465
12MP0005085_abnormal_gallbladder_physiolo2.55558237
13MP0009840_abnormal_foam_cell2.52417165
14MP0003705_abnormal_hypodermis_morpholog2.42828125
15MP0004087_abnormal_muscle_fiber2.31425182
16MP0005365_abnormal_bile_salt2.09434051
17MP0002972_abnormal_cardiac_muscle2.05010817
18MP0003252_abnormal_bile_duct1.99736986
19MP0004043_abnormal_pH_regulation1.97633538
20MP0008260_abnormal_autophagy1.97068324
21MP0000750_abnormal_muscle_regeneration1.92505718
22MP0005332_abnormal_amino_acid1.89113402
23MP0008775_abnormal_heart_ventricle1.86457960
24MP0005620_abnormal_muscle_contractility1.85226399
25MP0008875_abnormal_xenobiotic_pharmacok1.83195669
26MP0004264_abnormal_extraembryonic_tissu1.81223426
27MP0010630_abnormal_cardiac_muscle1.80335526
28MP0001666_abnormal_nutrient_absorption1.78804733
29MP0001544_abnormal_cardiovascular_syste1.78206210
30MP0005385_cardiovascular_system_phenoty1.78206210
31MP0010329_abnormal_lipoprotein_level1.77903679
32MP0000747_muscle_weakness1.76021247
33MP0002269_muscular_atrophy1.75860364
34MP0005670_abnormal_white_adipose1.74904812
35* MP0005666_abnormal_adipose_tissue1.74247684
36MP0003137_abnormal_impulse_conducting1.72351483
37MP0004185_abnormal_adipocyte_glucose1.71503517
38MP0006036_abnormal_mitochondrial_physio1.68192280
39MP0002106_abnormal_muscle_physiology1.67161812
40MP0004484_altered_response_of1.66581382
41MP0005409_darkened_coat_color1.66544798
42MP0003453_abnormal_keratinocyte_physiol1.66338723
43MP0003191_abnormal_cellular_cholesterol1.64456131
44MP0010234_abnormal_vibrissa_follicle1.64280479
45MP0003436_decreased_susceptibility_to1.60979377
46MP0006138_congestive_heart_failure1.57324447
47* MP0005451_abnormal_body_composition1.56487556
48MP0001849_ear_inflammation1.55886056
49MP0003806_abnormal_nucleotide_metabolis1.49940271
50MP0003221_abnormal_cardiomyocyte_apopto1.46936538
51MP0010155_abnormal_intestine_physiology1.46481908
52MP0004510_myositis1.42414901
53MP0009643_abnormal_urine_homeostasis1.41967310
54MP0003183_abnormal_peptide_metabolism1.41738604
55MP0000678_abnormal_parathyroid_gland1.41232284
56MP0000759_abnormal_skeletal_muscle1.38574426
57MP0005319_abnormal_enzyme/_coenzyme1.37446462
58MP0004947_skin_inflammation1.35654527
59MP0005083_abnormal_biliary_tract1.34327565
60MP0005076_abnormal_cell_differentiation1.32354440
61MP0003828_pulmonary_edema1.31506025
62* MP0002118_abnormal_lipid_homeostasis1.31480624
63MP0003195_calcinosis1.29749124
64MP0001873_stomach_inflammation1.29273559
65MP0004145_abnormal_muscle_electrophysio1.26580345
66MP0008961_abnormal_basal_metabolism1.25172013
67MP0005369_muscle_phenotype1.24466407
68MP0004019_abnormal_vitamin_homeostasis1.24032344
69MP0005584_abnormal_enzyme/coenzyme_acti1.19540049
70MP0002971_abnormal_brown_adipose1.19271536
71MP0005501_abnormal_skin_physiology1.17666011
72* MP0005375_adipose_tissue_phenotype1.16586414
73MP0002877_abnormal_melanocyte_morpholog1.15993433
74MP0000609_abnormal_liver_physiology1.13932285
75MP0002332_abnormal_exercise_endurance1.13787813
76MP0005167_abnormal_blood-brain_barrier1.13591545
77MP0000733_abnormal_muscle_development1.13159374
78MP0004085_abnormal_heartbeat1.12432288
79MP0003300_gastrointestinal_ulcer1.11468009
80MP0005058_abnormal_lysosome_morphology1.09700811
81MP0000858_altered_metastatic_potential1.06558056
82MP0003566_abnormal_cell_adhesion1.04531188
83MP0004233_abnormal_muscle_weight1.04377898
84MP0003879_abnormal_hair_cell1.02999184
85MP0000343_altered_response_to1.02925846
86MP0000490_abnormal_crypts_of1.02741810
87MP0002822_catalepsy1.02696402
88MP0001765_abnormal_ion_homeostasis1.02287450
89MP0009333_abnormal_splenocyte_physiolog1.00635902
90MP0001756_abnormal_urination0.99894454
91MP0002909_abnormal_adrenal_gland0.96706951
92MP0005025_abnormal_response_to0.96017122
93MP0005165_increased_susceptibility_to0.90468942
94MP0000230_abnormal_systemic_arterial0.89909849
95MP0006035_abnormal_mitochondrial_morpho0.87798425
96MP0005535_abnormal_body_temperature0.87642672
97MP0005266_abnormal_metabolism0.87424879
98MP0002419_abnormal_innate_immunity0.84682603
99MP0002078_abnormal_glucose_homeostasis0.84576297
100MP0004782_abnormal_surfactant_physiolog0.83314327
101MP0000685_abnormal_immune_system0.82177789
102MP0003091_abnormal_cell_migration0.80424764
103MP0001216_abnormal_epidermal_layer0.79111257
104MP0009278_abnormal_bone_marrow0.76961522
105MP0000467_abnormal_esophagus_morphology0.76872468
106MP0002136_abnormal_kidney_physiology0.76551583
107MP0000477_abnormal_intestine_morphology0.76132300
108MP0002796_impaired_skin_barrier0.75937211
109MP0002138_abnormal_hepatobiliary_system0.75806934
110MP0003283_abnormal_digestive_organ0.75585928
111MP0003075_altered_response_to0.74647743
112MP0001533_abnormal_skeleton_physiology0.74351971
113MP0005464_abnormal_platelet_physiology0.74290518
114MP0003172_abnormal_lysosome_physiology0.73329386
115MP0001661_extended_life_span0.72882146
116MP0005023_abnormal_wound_healing0.72732255
117MP0000003_abnormal_adipose_tissue0.70774928
118MP0005166_decreased_susceptibility_to0.68771820
119MP0003303_peritoneal_inflammation0.68576761
120MP0005636_abnormal_mineral_homeostasis0.67666282
121MP0000013_abnormal_adipose_tissue0.67575741
122* MP0005334_abnormal_fat_pad0.64206197
123MP0000266_abnormal_heart_morphology0.63023255
124MP0002234_abnormal_pharynx_morphology0.61881301
125MP0009780_abnormal_chondrocyte_physiolo0.60255621
126MP0004858_abnormal_nervous_system0.59769637
127MP0000604_amyloidosis0.59527373
128MP0003329_amyloid_beta_deposits0.59320466
129MP0003045_fibrosis0.57415373
130MP0009642_abnormal_blood_homeostasis0.56907299
131MP0010352_gastrointestinal_tract_polyps0.55664431
132MP0002127_abnormal_cardiovascular_syste0.55310668
133* MP0005448_abnormal_energy_balance0.54525448
134MP0003866_abnormal_defecation0.52122890

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.28877169
2Nemaline bodies (HP:0003798)4.73712221
3Exercise-induced myalgia (HP:0003738)4.65240412
4Exercise-induced muscle cramps (HP:0003710)4.59890449
5Ventricular tachycardia (HP:0004756)4.57701022
6Myoglobinuria (HP:0002913)4.54306825
7Right ventricular cardiomyopathy (HP:0011663)4.41312696
8Centrally nucleated skeletal muscle fibers (HP:0003687)4.18324001
9Myopathic facies (HP:0002058)4.16328669
10Muscle fiber splitting (HP:0003555)4.07206571
11Distal lower limb amyotrophy (HP:0008944)3.89002114
12Calf muscle hypertrophy (HP:0008981)3.84597742
13Hyperglycinuria (HP:0003108)3.73977337
14Hyporeflexia of lower limbs (HP:0002600)3.72342928
15Bundle branch block (HP:0011710)3.63865158
16Rhabdomyolysis (HP:0003201)3.58028338
17Muscle hypertrophy of the lower extremities (HP:0008968)3.56878965
18Ketoacidosis (HP:0001993)3.48498984
19Increased connective tissue (HP:0009025)3.46878688
20Abnormality of fatty-acid metabolism (HP:0004359)3.44847606
21Palpitations (HP:0001962)3.44341918
22Asymmetric septal hypertrophy (HP:0001670)3.40628856
23Hypoglycemic coma (HP:0001325)3.39729993
24Lipoatrophy (HP:0100578)3.31517419
25Syncope (HP:0001279)3.28467666
26Atrial fibrillation (HP:0005110)3.27442772
27Ketosis (HP:0001946)3.25140210
28Abnormality of the calf musculature (HP:0001430)3.20104136
29Difficulty running (HP:0009046)3.16224010
30Dicarboxylic aciduria (HP:0003215)3.11277449
31Abnormality of dicarboxylic acid metabolism (HP:0010995)3.11277449
32Subaortic stenosis (HP:0001682)3.06525051
33Abnormality of the left ventricular outflow tract (HP:0011103)3.06525051
34Hyperammonemia (HP:0001987)3.05732287
35Primary atrial arrhythmia (HP:0001692)3.05257422
36Abnormality of glycine metabolism (HP:0010895)3.04691931
37Abnormality of serine family amino acid metabolism (HP:0010894)3.04691931
38Ventricular arrhythmia (HP:0004308)2.99108049
39Abnormality of glutamine family amino acid metabolism (HP:0010902)2.98477182
40EMG: myopathic abnormalities (HP:0003458)2.96701482
41Heart block (HP:0012722)2.96464557
42Ventricular fibrillation (HP:0001663)2.96418816
43Gout (HP:0001997)2.96027386
44Dilated cardiomyopathy (HP:0001644)2.95186959
45Supraventricular tachycardia (HP:0004755)2.93409509
46Supraventricular arrhythmia (HP:0005115)2.91276854
47Atrioventricular block (HP:0001678)2.86649700
48Abnormal atrioventricular conduction (HP:0005150)2.86375233
49Bulbar palsy (HP:0001283)2.82540154
50Prolonged QT interval (HP:0001657)2.76447490
51Xanthomatosis (HP:0000991)2.69196448
52Eczematoid dermatitis (HP:0000976)2.62618626
53Conjunctival hamartoma (HP:0100780)2.58216516
54Lower limb amyotrophy (HP:0007210)2.55680597
55Round ear (HP:0100830)2.54296470
56Muscle stiffness (HP:0003552)2.53321291
57Difficulty climbing stairs (HP:0003551)2.53181858
58Myotonia (HP:0002486)2.47273443
59Abnormality of purine metabolism (HP:0004352)2.46836458
60Hydroxyprolinuria (HP:0003080)2.42595255
61Abnormality of proline metabolism (HP:0010907)2.42595255
62Generalized aminoaciduria (HP:0002909)2.41725085
63Achilles tendon contracture (HP:0001771)2.40448993
64Hyperuricemia (HP:0002149)2.38926223
65Increased purine levels (HP:0004368)2.38926223
66Hemorrhage of the eye (HP:0011885)2.37834225
67Type 1 muscle fiber predominance (HP:0003803)2.37212433
68Increased muscle lipid content (HP:0009058)2.34647734
69Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.30915329
70Abnormality of monocarboxylic acid metabolism (HP:0010996)2.30112956
71Ulnar deviation of the wrist (HP:0003049)2.27803044
72Proximal tubulopathy (HP:0000114)2.25796614
73Progressive muscle weakness (HP:0003323)2.24227821
74Foot dorsiflexor weakness (HP:0009027)2.21677911
75Dysmetric saccades (HP:0000641)2.20384633
76Hypoalphalipoproteinemia (HP:0003233)2.18904396
77Nausea (HP:0002018)2.17204629
78Systemic lupus erythematosus (HP:0002725)2.13528643
79Muscle fiber inclusion bodies (HP:0100299)2.12562499
80Metabolic acidosis (HP:0001942)2.11878817
81Hamartoma of the eye (HP:0010568)2.11716535
82Hepatic necrosis (HP:0002605)2.11375693
83Flat acetabular roof (HP:0003180)2.11238557
84Hyperglycinemia (HP:0002154)2.09422811
85Abnormality of the foot musculature (HP:0001436)2.08994098
86Thin bony cortex (HP:0002753)2.07642441
87Increased variability in muscle fiber diameter (HP:0003557)2.07384215
88Cerebral edema (HP:0002181)2.04780872
89Late onset (HP:0003584)2.04332939
90Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.04095623
91Distal arthrogryposis (HP:0005684)2.04017881
92Mildly elevated creatine phosphokinase (HP:0008180)2.02257729
93Axonal loss (HP:0003447)2.01247000
94Distal lower limb muscle weakness (HP:0009053)2.00932530
95Abnormal EKG (HP:0003115)1.98636280
96Ragged-red muscle fibers (HP:0003200)1.98227053
97Distal upper limb amyotrophy (HP:0007149)1.97616062
98Upper limb amyotrophy (HP:0009129)1.97616062
99Metabolic alkalosis (HP:0200114)1.97094604
100Abnormality of skeletal muscle fiber size (HP:0012084)1.93675137
101Cholelithiasis (HP:0001081)1.93088856
102Neoplasm of head and neck (HP:0012288)1.90241871
103Esophageal neoplasm (HP:0100751)1.90241871
104Stridor (HP:0010307)1.89547451
105Limb-girdle muscle atrophy (HP:0003797)1.89495572
106Ileus (HP:0002595)1.89267221
107Malnutrition (HP:0004395)1.89172646
108Easy fatigability (HP:0003388)1.88949861
109Lymphangioma (HP:0100764)1.88820389
110Lethargy (HP:0001254)1.88171100
111Facial diplegia (HP:0001349)1.87960161
112Vomiting (HP:0002013)1.87439499
113EMG: neuropathic changes (HP:0003445)1.84638135
114Frequent falls (HP:0002359)1.84456017
115Hypolipoproteinemia (HP:0010981)1.82071110
116Polycythemia (HP:0001901)1.81887324
117Abnormality of complement system (HP:0005339)1.81823335
118Testicular atrophy (HP:0000029)1.80909605
119Multiple enchondromatosis (HP:0005701)1.80336699
120Hyperactive renin-angiotensin system (HP:0000841)1.79806766
121Deep venous thrombosis (HP:0002625)1.79775480
122Vertebral compression fractures (HP:0002953)1.79360778
123Acute encephalopathy (HP:0006846)1.77833421
124Abnormality of the Achilles tendon (HP:0005109)1.77666559
125Neck muscle weakness (HP:0000467)1.77499297
126Generalized muscle weakness (HP:0003324)1.77356919
127Cerebral aneurysm (HP:0004944)1.77077534
128Spinal rigidity (HP:0003306)1.77023625
129Scapular winging (HP:0003691)1.76403489
130Diaphragmatic weakness (HP:0009113)1.74206265
131Colitis (HP:0002583)1.72985313
132Hyperparathyroidism (HP:0000843)1.68969282
133Cellulitis (HP:0100658)1.65576112
134Abdominal distention (HP:0003270)1.64887740
135Gingivitis (HP:0000230)1.62876577
136Abnormality of macrophages (HP:0004311)1.62647129
137Abnormal gallbladder physiology (HP:0012438)1.59794723
138Cholecystitis (HP:0001082)1.59794723
139Generalized amyotrophy (HP:0003700)1.59152356
140Hyperacusis (HP:0010780)1.58500559
141Increased serum ferritin (HP:0003281)1.57804165
142Rimmed vacuoles (HP:0003805)1.57711184
143Fatigue (HP:0012378)1.57440133
144Segmental peripheral demyelination/remyelination (HP:0003481)1.53331070
145Abnormality of liposaccharide metabolism (HP:0010968)1.51413840
146Abnormality of glycosphingolipid metabolism (HP:0004343)1.51413840
147Abnormality of glycolipid metabolism (HP:0010969)1.51413840
148Growth hormone excess (HP:0000845)1.51157117
149Glomerulonephritis (HP:0000099)1.50459023

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.42155598
2TTN4.34369601
3PKN23.36281543
4LMTK23.23908169
5BCKDK3.05827577
6PRPF4B2.91989810
7EPHA22.76227812
8IRAK32.74662406
9SMG12.62502520
10PDK42.53600740
11PDK32.53600740
12PHKG12.44350410
13PHKG22.44350410
14OBSCN2.34753671
15DMPK2.09686423
16RIPK12.05472698
17ERN12.02962103
18NEK11.88023129
19MYLK1.84683714
20PTK61.63552732
21MAP3K71.62640458
22WNK41.51580380
23PDK21.49984753
24MST1R1.48205089
25PINK11.46192548
26ARAF1.36923952
27TAOK21.34890648
28SIK11.32872672
29MAP3K131.30000045
30EEF2K1.28079269
31PIK3CA1.22887311
32MAP3K101.22115516
33TAOK11.21915483
34RIPK41.20980253
35FGFR41.16791865
36MAPKAPK31.16648728
37TESK11.10198215
38IRAK41.10059908
39TESK21.07138186
40MAP2K31.06282189
41STK381.05451315
42KSR21.01313912
43FRK0.99808309
44PRKAA20.99593441
45PRKG20.98465607
46IRAK20.97289288
47PRKD10.92222216
48EPHB10.91879175
49PRKAA10.90352346
50LRRK20.90125575
51PDPK10.89194063
52PRKD20.89100362
53MAP3K30.88995063
54ICK0.88411259
55PDGFRA0.86018791
56ZAP700.84737966
57TYK20.83143739
58PIM20.82790490
59ILK0.82761282
60GRK60.81973106
61PAK30.81634318
62BMX0.80420450
63MARK20.79168120
64DAPK30.77737434
65MET0.77327698
66PDK10.76071551
67TBK10.75975180
68MAPK110.75430382
69EPHB20.75303630
70MAPK120.74880511
71STK240.74833915
72MAP3K110.72936249
73PRKD30.72014912
74MUSK0.71993842
75WNK30.69966985
76RPS6KA20.69063760
77MAP4K10.68495338
78MAP3K50.68436981
79MAP3K60.68093230
80MAP3K140.67396861
81JAK10.66716125
82MTOR0.65553006
83LATS20.64959441
84TIE10.64482522
85BRAF0.64148643
86TGFBR20.63748969
87NME10.62423973
88CDK120.61844751
89MAP2K20.60592089
90RPS6KB20.59437160
91CDC42BPA0.58001824
92ROCK10.57661411
93JAK20.57156566
94MAP3K80.56437108
95MAP2K10.55125746
96MAP3K10.54620514
97PTK20.53548251
98CAMK2D0.52690061
99SGK30.52045907
100BLK0.51416925
101MAP3K90.50823867
102TNK20.49479061
103MAP2K60.48532349
104CAMK1D0.48523024
105CAMKK10.47977886
106RET0.47556774
107CAMK40.46973878
108CAMK2G0.46197794
109TAOK30.46037750
110PRKCH0.45628456
111FLT30.44442472
112RPS6KA60.43847208
113PRKACG0.43666485
114NME20.43326061
115STK38L0.43206898
116SCYL20.42964237
117TRPM70.42097034
118MAP2K40.41891380
119ABL20.41798411
120MOS0.41236672
121DYRK1B0.41028545
122NEK90.40790713
123WNK10.40585691
124MAP3K20.39533480
125STK110.39149068
126PIK3CG0.37618335
127PAK60.37548793
128KDR0.37160144
129DDR20.36915061
130CSK0.36554981
131AKT20.36035086
132DAPK20.36020081
133PAK40.35460263
134MAPK40.35390309
135FER0.34695145
136JAK30.33935456
137IRAK10.33146065
138RPS6KL10.33021187
139RPS6KC10.33021187

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.21315385
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.75380770
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17017396
4Fatty acid degradation_Homo sapiens_hsa000713.13112240
5Propanoate metabolism_Homo sapiens_hsa006402.97216273
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64448921
7Other glycan degradation_Homo sapiens_hsa005112.40621777
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.40359526
9Carbon metabolism_Homo sapiens_hsa012002.32913271
10Fatty acid metabolism_Homo sapiens_hsa012122.31654559
11Nitrogen metabolism_Homo sapiens_hsa009102.16418173
12Arginine biosynthesis_Homo sapiens_hsa002202.10725116
13PPAR signaling pathway_Homo sapiens_hsa033202.06736891
14Butanoate metabolism_Homo sapiens_hsa006502.03993453
15Pyruvate metabolism_Homo sapiens_hsa006201.82568160
16Cardiac muscle contraction_Homo sapiens_hsa042601.81328707
17Tryptophan metabolism_Homo sapiens_hsa003801.79662259
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71194502
19Fat digestion and absorption_Homo sapiens_hsa049751.69800906
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68366259
21Starch and sucrose metabolism_Homo sapiens_hsa005001.61698860
22Bile secretion_Homo sapiens_hsa049761.50959194
23Dilated cardiomyopathy_Homo sapiens_hsa054141.49404135
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.43024836
25Acute myeloid leukemia_Homo sapiens_hsa052211.42311693
26beta-Alanine metabolism_Homo sapiens_hsa004101.37277357
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34417321
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.30677853
29Biosynthesis of amino acids_Homo sapiens_hsa012301.29003297
30Peroxisome_Homo sapiens_hsa041461.25507576
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24702892
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19035952
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16431176
34Fructose and mannose metabolism_Homo sapiens_hsa000511.15822880
35Caffeine metabolism_Homo sapiens_hsa002321.14302700
36Chronic myeloid leukemia_Homo sapiens_hsa052201.11924254
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.08094568
38Galactose metabolism_Homo sapiens_hsa000521.06518502
39Bladder cancer_Homo sapiens_hsa052191.05100830
40Parkinsons disease_Homo sapiens_hsa050121.04984068
41Insulin resistance_Homo sapiens_hsa049311.03502783
42Prion diseases_Homo sapiens_hsa050201.03040585
43Fatty acid biosynthesis_Homo sapiens_hsa000611.03030463
44Sulfur metabolism_Homo sapiens_hsa009201.00295483
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99891026
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98037304
47B cell receptor signaling pathway_Homo sapiens_hsa046620.97594121
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97452577
49Oxidative phosphorylation_Homo sapiens_hsa001900.96247718
50Non-small cell lung cancer_Homo sapiens_hsa052230.93334137
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.92870728
52Hepatitis C_Homo sapiens_hsa051600.89992293
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88534071
54Lysine degradation_Homo sapiens_hsa003100.86915533
55Glycerolipid metabolism_Homo sapiens_hsa005610.86644783
56Osteoclast differentiation_Homo sapiens_hsa043800.86541830
57GnRH signaling pathway_Homo sapiens_hsa049120.85627594
58Leishmaniasis_Homo sapiens_hsa051400.84577125
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82087868
60Alzheimers disease_Homo sapiens_hsa050100.80602419
61Arginine and proline metabolism_Homo sapiens_hsa003300.80362575
62Mineral absorption_Homo sapiens_hsa049780.77501967
63Pancreatic cancer_Homo sapiens_hsa052120.76523170
64Phenylalanine metabolism_Homo sapiens_hsa003600.75383343
65Toxoplasmosis_Homo sapiens_hsa051450.73978877
66Thyroid cancer_Homo sapiens_hsa052160.73760994
67Pentose phosphate pathway_Homo sapiens_hsa000300.73424610
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73385773
69Notch signaling pathway_Homo sapiens_hsa043300.73312431
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72782043
71Sulfur relay system_Homo sapiens_hsa041220.72649324
72Insulin signaling pathway_Homo sapiens_hsa049100.71721384
73Fatty acid elongation_Homo sapiens_hsa000620.71341713
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70513330
75Glucagon signaling pathway_Homo sapiens_hsa049220.70180725
76Endometrial cancer_Homo sapiens_hsa052130.69402565
77AMPK signaling pathway_Homo sapiens_hsa041520.68709458
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68102726
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66975208
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64635733
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63477931
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63287147
83Tuberculosis_Homo sapiens_hsa051520.61711028
84Renal cell carcinoma_Homo sapiens_hsa052110.60327616
85Vitamin digestion and absorption_Homo sapiens_hsa049770.60102036
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.60063309
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60037644
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60011643
89Lysosome_Homo sapiens_hsa041420.58545972
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.56576258
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56220517
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55757942
93Apoptosis_Homo sapiens_hsa042100.54982349
94ABC transporters_Homo sapiens_hsa020100.54624141
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54319610
96Histidine metabolism_Homo sapiens_hsa003400.53436938
97TNF signaling pathway_Homo sapiens_hsa046680.53179877
98Influenza A_Homo sapiens_hsa051640.52764675
99Type II diabetes mellitus_Homo sapiens_hsa049300.52574299
100Viral myocarditis_Homo sapiens_hsa054160.50013606
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49577916
102Chemical carcinogenesis_Homo sapiens_hsa052040.49163899
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.48510395
104Folate biosynthesis_Homo sapiens_hsa007900.48171535
105Salmonella infection_Homo sapiens_hsa051320.47926582
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47595131
107Pertussis_Homo sapiens_hsa051330.46832404
108Renin-angiotensin system_Homo sapiens_hsa046140.46397166
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46091956
110Gastric acid secretion_Homo sapiens_hsa049710.45923513
111ErbB signaling pathway_Homo sapiens_hsa040120.42984723
112Glutathione metabolism_Homo sapiens_hsa004800.41824110
113Endocytosis_Homo sapiens_hsa041440.41051057
114Complement and coagulation cascades_Homo sapiens_hsa046100.40969326
115Protein digestion and absorption_Homo sapiens_hsa049740.40344952
116Prolactin signaling pathway_Homo sapiens_hsa049170.39390312
117Staphylococcus aureus infection_Homo sapiens_hsa051500.38808120
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38793550
119Small cell lung cancer_Homo sapiens_hsa052220.38210623
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37614784
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.37253917
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35633169
123HIF-1 signaling pathway_Homo sapiens_hsa040660.34732527
124Selenocompound metabolism_Homo sapiens_hsa004500.34431770
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33570885
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33462942
127Huntingtons disease_Homo sapiens_hsa050160.33253289
128Tyrosine metabolism_Homo sapiens_hsa003500.29953044
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29331975
130Amoebiasis_Homo sapiens_hsa051460.28915315
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.26963400
132Focal adhesion_Homo sapiens_hsa045100.26536505
133Tight junction_Homo sapiens_hsa045300.22627859
134VEGF signaling pathway_Homo sapiens_hsa043700.22484670
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.22253494
136Metabolic pathways_Homo sapiens_hsa011000.21668323
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.21281720
138mTOR signaling pathway_Homo sapiens_hsa041500.20131671
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16865150
140Thyroid hormone synthesis_Homo sapiens_hsa049180.16118966

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