ESRRB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)6.41549530
2regulation of posttranscriptional gene silencing (GO:0060147)6.41549530
3regulation of gene silencing by miRNA (GO:0060964)6.41549530
4nuclear pore organization (GO:0006999)5.33783816
5nuclear pore complex assembly (GO:0051292)5.05110826
6regulation of helicase activity (GO:0051095)4.99352629
7DNA replication-dependent nucleosome organization (GO:0034723)4.81135089
8DNA replication-dependent nucleosome assembly (GO:0006335)4.81135089
9determination of adult lifespan (GO:0008340)4.80487643
10somatic hypermutation of immunoglobulin genes (GO:0016446)4.77805046
11somatic diversification of immune receptors via somatic mutation (GO:0002566)4.77805046
12detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.77427923
13sensory perception of smell (GO:0007608)4.53427307
14protein localization to kinetochore (GO:0034501)4.52457376
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.39302083
16folic acid-containing compound biosynthetic process (GO:0009396)4.30666005
17DNA replication initiation (GO:0006270)4.29721252
18pre-miRNA processing (GO:0031054)4.23862076
19histone H4-K12 acetylation (GO:0043983)4.23821005
20regulation of translational fidelity (GO:0006450)4.23071717
21DNA unwinding involved in DNA replication (GO:0006268)4.22706603
22anterior/posterior axis specification, embryo (GO:0008595)4.18692184
23synapsis (GO:0007129)4.12485125
24negative regulation of histone methylation (GO:0031061)4.12118347
25mitotic nuclear envelope disassembly (GO:0007077)4.11871861
26mitotic sister chromatid segregation (GO:0000070)4.06568390
27heterochromatin organization (GO:0070828)4.06468607
28nucleobase biosynthetic process (GO:0046112)4.01886380
29regulation of histone H3-K9 methylation (GO:0051570)4.01795932
30positive regulation of SMAD protein import into nucleus (GO:0060391)3.99041858
31formation of translation preinitiation complex (GO:0001731)3.97511657
32oxygen transport (GO:0015671)3.95248869
33gas transport (GO:0015669)3.94368073
34mitotic metaphase plate congression (GO:0007080)3.93243766
35IMP biosynthetic process (GO:0006188)3.90139236
36DNA methylation involved in gamete generation (GO:0043046)3.87569333
37paraxial mesoderm development (GO:0048339)3.86143922
38membrane disassembly (GO:0030397)3.84849044
39nuclear envelope disassembly (GO:0051081)3.84849044
40ATP synthesis coupled proton transport (GO:0015986)3.83974204
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83974204
42male meiosis I (GO:0007141)3.83273781
43regulation of gene silencing (GO:0060968)3.82618561
44negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.78569824
45regulation of telomere maintenance via telomerase (GO:0032210)3.76775132
46pore complex assembly (GO:0046931)3.75948016
47DNA geometric change (GO:0032392)3.75724071
48DNA duplex unwinding (GO:0032508)3.75594776
49histone arginine methylation (GO:0034969)3.70824287
50protein K6-linked ubiquitination (GO:0085020)3.70178289
51establishment of apical/basal cell polarity (GO:0035089)3.68722345
52water-soluble vitamin biosynthetic process (GO:0042364)3.68709560
53resolution of meiotic recombination intermediates (GO:0000712)3.67972233
54sister chromatid segregation (GO:0000819)3.60812358
55purine nucleobase biosynthetic process (GO:0009113)3.59326043
56respiratory electron transport chain (GO:0022904)3.57824094
57protein localization to chromosome, centromeric region (GO:0071459)3.57185449
58electron transport chain (GO:0022900)3.56851635
59creatine metabolic process (GO:0006600)3.54503020
60DNA strand elongation involved in DNA replication (GO:0006271)3.52760606
61positive regulation of chromosome segregation (GO:0051984)3.51916393
62histone H2A monoubiquitination (GO:0035518)3.50047897
63rRNA modification (GO:0000154)3.45322722
64DNA deamination (GO:0045006)3.43403652
65mitochondrial respiratory chain complex I assembly (GO:0032981)3.42948265
66NADH dehydrogenase complex assembly (GO:0010257)3.42948265
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42948265
68ubiquinone biosynthetic process (GO:0006744)3.41865800
69DNA replication checkpoint (GO:0000076)3.41833811
70ribosome biogenesis (GO:0042254)3.40783011
71negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.40760554
72regulation of nuclear cell cycle DNA replication (GO:0033262)3.39640938
73ribosomal small subunit assembly (GO:0000028)3.37498877
74mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.37125697
75chromatin assembly (GO:0031497)3.37004017
76regulation of hippo signaling (GO:0035330)3.36729612
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36203398
78IMP metabolic process (GO:0046040)3.35942449
79metaphase plate congression (GO:0051310)3.35166715
80negative regulation of gene silencing (GO:0060969)3.33878023
81ribosome assembly (GO:0042255)3.33443057
82DNA strand elongation (GO:0022616)3.32895922
83rRNA catabolic process (GO:0016075)3.30347873
84detection of chemical stimulus involved in sensory perception (GO:0050907)3.27698143
85histone H4-K8 acetylation (GO:0043982)3.25744773
86histone H4-K5 acetylation (GO:0043981)3.25744773
87behavioral response to nicotine (GO:0035095)3.25006036
88protein complex biogenesis (GO:0070271)3.24930864
89piRNA metabolic process (GO:0034587)3.24186786
90peptidyl-arginine omega-N-methylation (GO:0035247)3.23195245
91regulation of retinoic acid receptor signaling pathway (GO:0048385)3.22452150
92regulation of SMAD protein import into nucleus (GO:0060390)3.22405123
93ubiquinone metabolic process (GO:0006743)3.20874793
94male meiosis (GO:0007140)3.20799863
95cellular ketone body metabolic process (GO:0046950)3.18645768
96RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.17743792
97S-adenosylmethionine metabolic process (GO:0046500)3.17396202
98regulation of mitochondrial translation (GO:0070129)3.16181695
99positive regulation of megakaryocyte differentiation (GO:0045654)3.15969679
100trophectodermal cell differentiation (GO:0001829)3.15099632
101regulation of mitotic spindle organization (GO:0060236)3.14793031
102spindle assembly involved in mitosis (GO:0090307)3.14770201
103negative regulation of transcription regulatory region DNA binding (GO:2000678)3.14163160
104regulation of translational termination (GO:0006449)3.14009439
105establishment or maintenance of monopolar cell polarity (GO:0061339)3.13623899
106establishment of monopolar cell polarity (GO:0061162)3.13623899
107regulation of spindle organization (GO:0090224)3.12255138
108positive regulation of mitotic sister chromatid separation (GO:1901970)3.11953452
109positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11953452
110positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11953452
111spliceosomal tri-snRNP complex assembly (GO:0000244)3.11469488
112mitochondrial respiratory chain complex assembly (GO:0033108)3.11278592
113terpenoid biosynthetic process (GO:0016114)3.11009292
114proteasome assembly (GO:0043248)3.09314007
115regulation of meiosis I (GO:0060631)3.06672182
116mitotic chromosome condensation (GO:0007076)3.06538586
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05169111
118regulation of sister chromatid cohesion (GO:0007063)3.05067023
119maturation of SSU-rRNA (GO:0030490)3.04661940
120pseudouridine synthesis (GO:0001522)3.03530619
121telomere maintenance via semi-conservative replication (GO:0032201)3.03265550
122ATP biosynthetic process (GO:0006754)2.98849283
123meiosis I (GO:0007127)2.98589437
124negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.97444753
125nuclear envelope organization (GO:0006998)2.95826298
126regulation of histone H3-K4 methylation (GO:0051569)2.93732408
127intestinal epithelial cell development (GO:0060576)2.92540268
128chromosome organization involved in meiosis (GO:0070192)2.91141840
129regulation of centrosome cycle (GO:0046605)2.90554867
130meiotic chromosome segregation (GO:0045132)2.89681359
131replication fork processing (GO:0031297)2.89592062
132protein-cofactor linkage (GO:0018065)2.88678467
133dosage compensation (GO:0007549)2.88500340
134isoprenoid biosynthetic process (GO:0008299)2.87482255
135microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.87125178
136apoptotic process involved in morphogenesis (GO:0060561)2.85838513
137nodal signaling pathway (GO:0038092)2.85354954
138ketone body metabolic process (GO:1902224)2.85305435
139embryonic process involved in female pregnancy (GO:0060136)2.84383859
140negative regulation of androgen receptor signaling pathway (GO:0060766)2.83899939
141establishment of chromosome localization (GO:0051303)2.82315376
142chaperone-mediated protein complex assembly (GO:0051131)2.82174035
143ribonucleoprotein complex biogenesis (GO:0022613)2.81855794
144DNA conformation change (GO:0071103)2.80840752
145intra-S DNA damage checkpoint (GO:0031573)2.80077374
146mRNA transport (GO:0051028)2.79482001
147mismatch repair (GO:0006298)2.78230187
148establishment of protein localization to mitochondrial membrane (GO:0090151)2.77399918
149spindle assembly (GO:0051225)2.76790398
150peptidyl-arginine methylation (GO:0018216)2.76665363
151peptidyl-arginine N-methylation (GO:0035246)2.76665363
152regulation of chromosome segregation (GO:0051983)2.76435072
153centriole replication (GO:0007099)2.74918041
154positive regulation of histone H3-K4 methylation (GO:0051571)2.74183737
155protoporphyrinogen IX metabolic process (GO:0046501)2.72578777
156oxidative phosphorylation (GO:0006119)2.70236832
157rRNA methylation (GO:0031167)2.70109870
158short-chain fatty acid metabolic process (GO:0046459)2.68933961
159respiratory chain complex IV assembly (GO:0008535)2.66936272
160sensory perception of chemical stimulus (GO:0007606)2.66652760
161protoporphyrinogen IX biosynthetic process (GO:0006782)2.64775277
162negative regulation of DNA-templated transcription, elongation (GO:0032785)2.62914169
163quinone biosynthetic process (GO:1901663)2.62253589
164double-strand break repair via homologous recombination (GO:0000724)2.61414290
165ADP metabolic process (GO:0046031)2.58786327
166positive regulation of potassium ion transmembrane transport (GO:1901381)2.58041502
167regulation of rhodopsin mediated signaling pathway (GO:0022400)2.57385795
168parturition (GO:0007567)2.56863104
169recombinational repair (GO:0000725)2.56454846
170purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.52887678
171homocysteine metabolic process (GO:0050667)2.52583712
172protein polyglutamylation (GO:0018095)2.52051870
173purine nucleoside triphosphate biosynthetic process (GO:0009145)2.51657402
174cellular respiration (GO:0045333)2.49837375
175negative regulation of heart rate (GO:0010459)2.48322881
176tetrapyrrole biosynthetic process (GO:0033014)2.48288890
177tRNA processing (GO:0008033)2.48214954
178nucleoside transmembrane transport (GO:1901642)2.46986469
179mitochondrial RNA metabolic process (GO:0000959)2.46930466
180tRNA modification (GO:0006400)2.46584782
181diterpenoid biosynthetic process (GO:0016102)2.46296594
182positive regulation of sodium ion transmembrane transport (GO:1902307)2.45235179
183negative regulation of potassium ion transmembrane transport (GO:1901380)2.45030191
184aerobic respiration (GO:0009060)2.44246301
185regulation of skeletal muscle contraction (GO:0014819)2.43332263
186vitamin A metabolic process (GO:0006776)2.42839190
187somite development (GO:0061053)2.42415863
188erythrocyte development (GO:0048821)2.42076291
189cellular response to ATP (GO:0071318)2.41896970
190tRNA metabolic process (GO:0006399)2.39599211
191reciprocal meiotic recombination (GO:0007131)2.39555054
192reciprocal DNA recombination (GO:0035825)2.39555054
193cellular component biogenesis (GO:0044085)2.38923086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.84602158
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.04096950
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.04096950
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.04096950
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.75766883
6VDR_22108803_ChIP-Seq_LS180_Human3.63109468
7EZH2_22144423_ChIP-Seq_EOC_Human3.62749164
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.57922520
9* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.55049842
10* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.16365738
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10583782
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.97477487
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.94050878
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.84722996
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.77020955
16ZNF274_21170338_ChIP-Seq_K562_Hela2.69936308
17NANOG_18555785_ChIP-Seq_MESCs_Mouse2.66935472
18* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.59495745
19TCF3_18692474_ChIP-Seq_MEFs_Mouse2.51809894
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51459938
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49097657
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48807284
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42630761
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.36971357
25STAT3_1855785_ChIP-Seq_MESCs_Mouse2.36466898
26SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.35699273
27TCF3_18692474_ChIP-Seq_MESCs_Mouse2.30239843
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29241659
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.24722254
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.19090250
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.18353573
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17214307
33SOX2_18555785_ChIP-Seq_MESCs_Mouse2.16867581
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.16434109
35MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15567250
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.08706729
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.06919699
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04531423
39RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03078573
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03074161
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01974024
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99823414
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.89033989
44NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.88316854
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.86200614
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.79787782
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76137214
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.72181351
49* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.70203746
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69706563
51* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64608808
52* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.64030903
53IGF1R_20145208_ChIP-Seq_DFB_Human1.63583219
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61755780
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61492221
56XRN2_22483619_ChIP-Seq_HELA_Human1.60550019
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.59188301
58SOX2_18692474_ChIP-Seq_MEFs_Mouse1.58299750
59SOX2_18692474_ChIP-Seq_MESCs_Mouse1.57430560
60TP53_22573176_ChIP-Seq_HFKS_Human1.57273177
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.57117483
62IRF1_19129219_ChIP-ChIP_H3396_Human1.56827152
63NANOG_21062744_ChIP-ChIP_HESCs_Human1.52796702
64NANOG_18692474_ChIP-Seq_MEFs_Mouse1.52450365
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.51926992
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49976489
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.49266834
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48446558
69NANOG_18692474_ChIP-Seq_MESCs_Mouse1.47665103
70PHF8_20622853_ChIP-Seq_HELA_Human1.46712505
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44957737
72ELK1_19687146_ChIP-ChIP_HELA_Human1.43068524
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42450051
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41128855
75OCT4_18692474_ChIP-Seq_MEFs_Mouse1.39659324
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.38342912
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38018265
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37762120
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37348695
80AR_21909140_ChIP-Seq_LNCAP_Human1.36431484
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35410698
82MYC_18940864_ChIP-ChIP_HL60_Human1.35331696
83NCOR1_26117541_ChIP-Seq_K562_Human1.34402477
84* GATA3_21878914_ChIP-Seq_MCF-7_Human1.34065447
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33973393
86POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.33151401
87CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.32592832
88GATA6_21074721_ChIP-Seq_CACO-2_Human1.32285143
89ETV1_20927104_ChIP-Seq_GIST48_Human1.30613534
90MYC_22102868_ChIP-Seq_BL_Human1.30554617
91THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28456826
92TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.27489796
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.27074241
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26999399
95RBPJ_21746931_ChIP-Seq_IB4_Human1.26248481
96KAP1_27257070_Chip-Seq_ESCs_Mouse1.22510810
97* EWS_26573619_Chip-Seq_HEK293_Human1.21789099
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21521317
99RNF2_27304074_Chip-Seq_NSC_Mouse1.21414542
100TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20988530
101PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20099853
102ZNF263_19887448_ChIP-Seq_K562_Human1.18799803
103OCT4_20526341_ChIP-Seq_ESCs_Human1.18602163
104TTF2_22483619_ChIP-Seq_HELA_Human1.17793720
105ERA_21632823_ChIP-Seq_H3396_Human1.17507943
106* P53_21459846_ChIP-Seq_SAOS-2_Human1.17015691
107ER_23166858_ChIP-Seq_MCF-7_Human1.16555450
108YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16095163
109* NCOR_22424771_ChIP-Seq_293T_Human1.15374948
110KDM5A_27292631_Chip-Seq_BREAST_Human1.15133827
111GATA1_19941826_ChIP-Seq_K562_Human1.13878130
112FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12937543
113* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12812081
114POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12794256
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12559612
116NFYB_21822215_ChIP-Seq_K562_Human1.11851000
117HNFA_21074721_ChIP-Seq_CACO-2_Human1.10004728
118PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09872704
119PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09792770
120CBX2_27304074_Chip-Seq_ESCs_Mouse1.09611288
121AR_20517297_ChIP-Seq_VCAP_Human1.09578674
122VDR_23849224_ChIP-Seq_CD4+_Human1.09558997
123ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08516950
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06508498
125HOXB7_26014856_ChIP-Seq_BT474_Human1.06344546
126FOXP3_21729870_ChIP-Seq_TREG_Human1.05836926
127CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05833881
128* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05692024
129* NANOG_16518401_ChIP-PET_MESCs_Mouse1.05130268
130DCP1A_22483619_ChIP-Seq_HELA_Human1.03798077
131CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03757096
132SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02937220
133POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02660271
134TAF2_19829295_ChIP-Seq_ESCs_Human1.02631241
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02611002
136GABP_19822575_ChIP-Seq_HepG2_Human1.02502564
137CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02236677
138HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00533964
139ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00422212
140TFEB_21752829_ChIP-Seq_HELA_Human0.99543316
141RAC3_21632823_ChIP-Seq_H3396_Human0.99448632
142GABP_17652178_ChIP-ChIP_JURKAT_Human0.98959521
143TP63_19390658_ChIP-ChIP_HaCaT_Human0.98206052
144NFYA_21822215_ChIP-Seq_K562_Human0.98203972
145CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97901378
146RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97305945
147ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96951825
148* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96948062
149NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96245412
150SOX2_19829295_ChIP-Seq_ESCs_Human0.95506803
151NANOG_19829295_ChIP-Seq_ESCs_Human0.95506803
152HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95180416
153NANOG_20526341_ChIP-Seq_ESCs_Human0.95174457
154CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94504292
155* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94479425
156CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93804244
157CIITA_25753668_ChIP-Seq_RAJI_Human0.93732494
158HTT_18923047_ChIP-ChIP_STHdh_Human0.93449858
159* FOXA1_25329375_ChIP-Seq_VCAP_Human0.93111859
160* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93111859
161BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92724524
162DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92678398
163FOXH1_21741376_ChIP-Seq_EPCs_Human0.91760592
164MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91049911
165EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90725646
166GATA2_19941826_ChIP-Seq_K562_Human0.90022357
167CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89932557
168ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89347251
169PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87582754
170SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82639972
171EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81683803
172NANOG_16153702_ChIP-ChIP_HESCs_Human0.79419709
173SOX2_16153702_ChIP-ChIP_HESCs_Human0.79079242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.52730040
2MP0008057_abnormal_DNA_replication4.42397661
3MP0004957_abnormal_blastocyst_morpholog4.08399566
4MP0004147_increased_porphyrin_level3.96036487
5MP0010094_abnormal_chromosome_stability3.93910816
6MP0003111_abnormal_nucleus_morphology3.91288812
7MP0003693_abnormal_embryo_hatching3.56730537
8MP0002653_abnormal_ependyma_morphology3.45331468
9MP0004145_abnormal_muscle_electrophysio3.41176681
10MP0003077_abnormal_cell_cycle3.26338378
11MP0008995_early_reproductive_senescence3.17249053
12MP0003806_abnormal_nucleotide_metabolis3.05593426
13MP0002837_dystrophic_cardiac_calcinosis2.84750543
14MP0010352_gastrointestinal_tract_polyps2.84724085
15MP0005646_abnormal_pituitary_gland2.83424854
16MP0004133_heterotaxia2.77945794
17MP0008058_abnormal_DNA_repair2.68385001
18MP0001730_embryonic_growth_arrest2.42634497
19MP0000350_abnormal_cell_proliferation2.33129266
20MP0000372_irregular_coat_pigmentation2.32939153
21MP0003283_abnormal_digestive_organ2.31764377
22MP0002132_abnormal_respiratory_system2.28754309
23MP0003136_yellow_coat_color2.24482550
24MP0002084_abnormal_developmental_patter2.21756459
25MP0006036_abnormal_mitochondrial_physio2.11576086
26MP0004043_abnormal_pH_regulation2.09335059
27MP0002138_abnormal_hepatobiliary_system2.08845961
28* MP0002085_abnormal_embryonic_tissue2.07289215
29* MP0005380_embryogenesis_phenotype2.05804739
30* MP0001672_abnormal_embryogenesis/_devel2.05804739
31MP0001986_abnormal_taste_sensitivity2.03081289
32MP0008932_abnormal_embryonic_tissue2.00772073
33MP0010307_abnormal_tumor_latency1.96183060
34MP0003011_delayed_dark_adaptation1.95182101
35MP0003195_calcinosis1.94442711
36MP0003890_abnormal_embryonic-extraembry1.93812847
37MP0003123_paternal_imprinting1.92228668
38MP0000678_abnormal_parathyroid_gland1.92133598
39MP0006072_abnormal_retinal_apoptosis1.90598923
40* MP0002086_abnormal_extraembryonic_tissu1.88730627
41MP0004197_abnormal_fetal_growth/weight/1.86565464
42* MP0001697_abnormal_embryo_size1.84983278
43MP0005076_abnormal_cell_differentiation1.83226626
44MP0003705_abnormal_hypodermis_morpholog1.79361330
45MP0008775_abnormal_heart_ventricle1.78908674
46MP0003119_abnormal_digestive_system1.77029624
47* MP0003984_embryonic_growth_retardation1.74783254
48* MP0002088_abnormal_embryonic_growth/wei1.72369594
49MP0001293_anophthalmia1.71382457
50MP0003786_premature_aging1.64263246
51MP0002102_abnormal_ear_morphology1.63538283
52* MP0002080_prenatal_lethality1.62929238
53MP0008007_abnormal_cellular_replicative1.62517612
54MP0003941_abnormal_skin_development1.62083681
55MP0003950_abnormal_plasma_membrane1.58676892
56MP0004264_abnormal_extraembryonic_tissu1.58508446
57MP0001661_extended_life_span1.57356932
58MP0008872_abnormal_physiological_respon1.52362288
59MP0004036_abnormal_muscle_relaxation1.50285270
60MP0002160_abnormal_reproductive_system1.50233175
61MP0003718_maternal_effect1.49116366
62MP0000631_abnormal_neuroendocrine_gland1.47508372
63MP0006292_abnormal_olfactory_placode1.43345900
64MP0005083_abnormal_biliary_tract1.40606035
65MP0005253_abnormal_eye_physiology1.38253451
66MP0010030_abnormal_orbit_morphology1.38237049
67MP0003567_abnormal_fetal_cardiomyocyte1.38146607
68MP0001529_abnormal_vocalization1.36780459
69MP0005410_abnormal_fertilization1.36261731
70MP0004215_abnormal_myocardial_fiber1.35464225
71MP0001764_abnormal_homeostasis1.34956680
72MP0002876_abnormal_thyroid_physiology1.34524888
73MP0004233_abnormal_muscle_weight1.32114338
74MP0001968_abnormal_touch/_nociception1.29615801
75MP0005360_urolithiasis1.28757788
76MP0003566_abnormal_cell_adhesion1.27861516
77MP0005636_abnormal_mineral_homeostasis1.27038026
78MP0005266_abnormal_metabolism1.26897038
79MP0001849_ear_inflammation1.26630303
80MP0004142_abnormal_muscle_tone1.24854999
81MP0008877_abnormal_DNA_methylation1.21181216
82MP0003121_genomic_imprinting1.17608622
83MP0005389_reproductive_system_phenotype1.16378495
84MP0005551_abnormal_eye_electrophysiolog1.16248698
85MP0006035_abnormal_mitochondrial_morpho1.16151920
86MP0004130_abnormal_muscle_cell1.15666015
87MP0010234_abnormal_vibrissa_follicle1.14391244
88MP0005332_abnormal_amino_acid1.13934529
89MP0006276_abnormal_autonomic_nervous1.12125014
90MP0000313_abnormal_cell_death1.11581480
91MP0002234_abnormal_pharynx_morphology1.10830047
92MP0005391_vision/eye_phenotype1.10291366
93MP0003656_abnormal_erythrocyte_physiolo1.08401721
94MP0003698_abnormal_male_reproductive1.08307014
95MP0005397_hematopoietic_system_phenotyp1.08302566
96MP0001545_abnormal_hematopoietic_system1.08302566
97MP0004019_abnormal_vitamin_homeostasis1.07020563
98MP0001145_abnormal_male_reproductive1.06991004
99MP0002210_abnormal_sex_determination1.06894876
100MP0002163_abnormal_gland_morphology1.06683471
101MP0000490_abnormal_crypts_of1.05673458
102MP0005423_abnormal_somatic_nervous1.04070647
103MP0002127_abnormal_cardiovascular_syste1.03771023
104MP0005645_abnormal_hypothalamus_physiol1.01314804
105MP0001286_abnormal_eye_development1.00948903
106MP0002269_muscular_atrophy1.00412430
107MP0002332_abnormal_exercise_endurance1.00161580
108MP0003186_abnormal_redox_activity0.99568308
109MP0004185_abnormal_adipocyte_glucose0.95022411
110MP0002638_abnormal_pupillary_reflex0.94368327
111MP0002019_abnormal_tumor_incidence0.93046450
112MP0003861_abnormal_nervous_system0.92842483
113MP0005623_abnormal_meninges_morphology0.92411027
114MP0003938_abnormal_ear_development0.92329029
115MP0002697_abnormal_eye_size0.91892143
116MP0002111_abnormal_tail_morphology0.91395552
117MP0000749_muscle_degeneration0.91071624
118MP0008875_abnormal_xenobiotic_pharmacok0.88877827
119MP0009697_abnormal_copulation0.87140050
120MP0009703_decreased_birth_body0.86801332
121MP0005023_abnormal_wound_healing0.85047898
122MP0004084_abnormal_cardiac_muscle0.83868277
123MP0000516_abnormal_urinary_system0.83552633
124MP0005367_renal/urinary_system_phenotyp0.83552633
125MP0002249_abnormal_larynx_morphology0.83380391
126MP0000371_diluted_coat_color0.83353503
127MP0002736_abnormal_nociception_after0.82964679
128MP0001929_abnormal_gametogenesis0.82274839
129MP0005220_abnormal_exocrine_pancreas0.82240756
130MP0005501_abnormal_skin_physiology0.81727399
131MP0005075_abnormal_melanosome_morpholog0.80805521
132MP0003879_abnormal_hair_cell0.80578031
133MP0001919_abnormal_reproductive_system0.80220412
134MP0003937_abnormal_limbs/digits/tail_de0.79939298
135MP0002092_abnormal_eye_morphology0.79717870
136MP0002106_abnormal_muscle_physiology0.78986773
137MP0009745_abnormal_behavioral_response0.78807001
138MP0000537_abnormal_urethra_morphology0.78668338
139MP0000653_abnormal_sex_gland0.78607330
140MP0002733_abnormal_thermal_nociception0.78071476
141MP0002796_impaired_skin_barrier0.77867295
142MP0002272_abnormal_nervous_system0.77860865
143MP0005670_abnormal_white_adipose0.77383480
144MP0002925_abnormal_cardiovascular_devel0.76584973
145MP0002822_catalepsy0.74708904
146MP0004085_abnormal_heartbeat0.74679467
147MP0009053_abnormal_anal_canal0.74419499
148MP0002877_abnormal_melanocyte_morpholog0.72629805
149MP0000432_abnormal_head_morphology0.72623538
150MP0001544_abnormal_cardiovascular_syste0.72614542
151MP0005385_cardiovascular_system_phenoty0.72614542
152* MP0004885_abnormal_endolymph0.72330702
153MP0002095_abnormal_skin_pigmentation0.71473801
154MP0000358_abnormal_cell_content/0.71420807
155MP0003936_abnormal_reproductive_system0.71333110
156MP0005384_cellular_phenotype0.70448777
157MP0003137_abnormal_impulse_conducting0.70023709
158MP0008770_decreased_survivor_rate0.69927783
159MP0001915_intracranial_hemorrhage0.69575059
160MP0009046_muscle_twitch0.69514415
161MP0005621_abnormal_cell_physiology0.68778062
162MP0005195_abnormal_posterior_eye0.68449447
163MP0003942_abnormal_urinary_system0.66980635
164MP0009643_abnormal_urine_homeostasis0.66039353
165MP0005377_hearing/vestibular/ear_phenot0.64595331
166MP0003878_abnormal_ear_physiology0.64595331
167MP0000613_abnormal_salivary_gland0.64334564
168MP0009278_abnormal_bone_marrow0.64135079
169MP0000467_abnormal_esophagus_morphology0.63943111
170MP0002075_abnormal_coat/hair_pigmentati0.62068067
171MP0003755_abnormal_palate_morphology0.61905716
172MP0003935_abnormal_craniofacial_develop0.61748842
173MP0000750_abnormal_muscle_regeneration0.59849007
174MP0003315_abnormal_perineum_morphology0.59690509

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)6.39025250
2Astrocytoma (HP:0009592)4.69083928
3Abnormality of the astrocytes (HP:0100707)4.69083928
4Abnormality of the labia minora (HP:0012880)4.63811696
5Neoplasm of the oral cavity (HP:0100649)4.24406080
6Medulloblastoma (HP:0002885)4.10735087
7Truncus arteriosus (HP:0001660)3.92899267
8Rhabdomyosarcoma (HP:0002859)3.77666386
9Glioma (HP:0009733)3.75335290
10Rib fusion (HP:0000902)3.74437839
11Hyperthyroidism (HP:0000836)3.72925947
12Agnosia (HP:0010524)3.68578585
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.64849502
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.62898631
15Acute necrotizing encephalopathy (HP:0006965)3.54981589
16Absent radius (HP:0003974)3.53828608
17Chromsome breakage (HP:0040012)3.50690674
18Supernumerary spleens (HP:0009799)3.48501029
19Breast hypoplasia (HP:0003187)3.47023817
20Acute encephalopathy (HP:0006846)3.42883419
21Abnormal mitochondria in muscle tissue (HP:0008316)3.41745978
22Aplasia/hypoplasia of the humerus (HP:0006507)3.34143927
23Neoplasm of striated muscle (HP:0009728)3.33083540
24Aplasia involving forearm bones (HP:0009822)3.31838188
25Absent forearm bone (HP:0003953)3.31838188
26Selective tooth agenesis (HP:0001592)3.27169075
27Short humerus (HP:0005792)3.26951951
28Abnormality of the salivary glands (HP:0010286)3.24790224
29Birth length less than 3rd percentile (HP:0003561)3.20203166
30Congenital stationary night blindness (HP:0007642)3.08298624
31Abnormality of the renal collecting system (HP:0004742)3.05431857
32Increased CSF lactate (HP:0002490)3.04042785
33Shawl scrotum (HP:0000049)3.02759593
34Colon cancer (HP:0003003)3.00520497
35Impulsivity (HP:0100710)2.95345833
36Missing ribs (HP:0000921)2.92377101
37Progressive macrocephaly (HP:0004481)2.91333004
38Esophageal atresia (HP:0002032)2.89899094
39Mitochondrial inheritance (HP:0001427)2.84732743
40Abdominal situs inversus (HP:0003363)2.82973835
41Abnormality of abdominal situs (HP:0011620)2.82973835
42Bony spicule pigmentary retinopathy (HP:0007737)2.82863615
43Rectal fistula (HP:0100590)2.81120964
44Rectovaginal fistula (HP:0000143)2.81120964
45Methylmalonic acidemia (HP:0002912)2.75815066
46Increased circulating renin level (HP:0000848)2.71303978
47Abnormality of cochlea (HP:0000375)2.70435674
48Abnormal number of erythroid precursors (HP:0012131)2.69983885
49Reticulocytosis (HP:0001923)2.65139898
50Patellar aplasia (HP:0006443)2.65073046
51Abnormal number of incisors (HP:0011064)2.64563977
52Biliary tract neoplasm (HP:0100574)2.62013896
53Abnormality of the lower motor neuron (HP:0002366)2.60105330
54Renal cortical cysts (HP:0000803)2.58920178
55Abnormality of cells of the erythroid lineage (HP:0012130)2.56018527
56Vertebral clefting (HP:0008428)2.55569374
57Abnormality of reticulocytes (HP:0004312)2.55241187
58Basal cell carcinoma (HP:0002671)2.54567621
59Absent thumb (HP:0009777)2.53624209
60Hepatic necrosis (HP:0002605)2.53419202
61Intestinal fistula (HP:0100819)2.52688561
62Pendular nystagmus (HP:0012043)2.51711208
63Abnormality of the renal cortex (HP:0011035)2.48266096
64Poikilocytosis (HP:0004447)2.47608522
65Pancreatic cysts (HP:0001737)2.47581478
66Hepatocellular necrosis (HP:0001404)2.46957769
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.46706553
68Abnormality of the ileum (HP:0001549)2.45369034
69Pancreatic fibrosis (HP:0100732)2.44728855
70Meckel diverticulum (HP:0002245)2.42294110
71Metabolic alkalosis (HP:0200114)2.41332497
72Molar tooth sign on MRI (HP:0002419)2.39431089
73Abnormality of midbrain morphology (HP:0002418)2.39431089
74Pallor (HP:0000980)2.39191685
75Abnormality of chromosome stability (HP:0003220)2.39162306
76Aplasia/Hypoplasia of the patella (HP:0006498)2.39151994
77Carpal bone hypoplasia (HP:0001498)2.38372542
78Abnormality of homocysteine metabolism (HP:0010919)2.37026075
79Homocystinuria (HP:0002156)2.37026075
80Increased serum lactate (HP:0002151)2.34938438
81Abnormal hemoglobin (HP:0011902)2.34848822
82Abnormality of DNA repair (HP:0003254)2.34781027
83Angiofibromas (HP:0010615)2.31617481
84Adenoma sebaceum (HP:0009720)2.31617481
85Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.31126769
86Vaginal fistula (HP:0004320)2.31011149
87Type II lissencephaly (HP:0007260)2.31000004
88Hypomagnesemia (HP:0002917)2.29596268
89Supernumerary ribs (HP:0005815)2.26248799
90Supernumerary bones of the axial skeleton (HP:0009144)2.25449611
91Abnormality of the preputium (HP:0100587)2.24528176
92Tetany (HP:0001281)2.23135127
93Reticulocytopenia (HP:0001896)2.22169497
94Gastrointestinal atresia (HP:0002589)2.21900227
95Polyuria (HP:0000103)2.21779279
96Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.21524689
97Nephronophthisis (HP:0000090)2.21482396
98Hypokalemic alkalosis (HP:0001949)2.20622276
99Abnormality of the aortic arch (HP:0012303)2.14123741
100Delayed puberty (HP:0000823)2.13985245
101Lipid accumulation in hepatocytes (HP:0006561)2.13330942
102Abnormality of the phalanges of the 5th finger (HP:0004213)2.13102070
103Concave nail (HP:0001598)2.12852382
104Polydipsia (HP:0001959)2.12796219
105Abnormal drinking behavior (HP:0030082)2.12796219
106Decreased central vision (HP:0007663)2.12516867
107Dynein arm defect of respiratory motile cilia (HP:0012255)2.12019097
108Absent/shortened dynein arms (HP:0200106)2.12019097
109Proximal placement of thumb (HP:0009623)2.11853601
110Duplicated collecting system (HP:0000081)2.09536156
111Abnormal rod and cone electroretinograms (HP:0008323)2.08911248
112Amaurosis fugax (HP:0100576)2.08154691
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08096405
114Abnormality of alanine metabolism (HP:0010916)2.08096405
115Hyperalaninemia (HP:0003348)2.08096405
116Premature ovarian failure (HP:0008209)2.07994140
117Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06682391
118Increased intramyocellular lipid droplets (HP:0012240)2.06436637
119Methylmalonic aciduria (HP:0012120)2.06081288
120Muscle fiber inclusion bodies (HP:0100299)2.06024872
121Oral leukoplakia (HP:0002745)2.05850067
122Metaphyseal cupping (HP:0003021)2.05386065
123Abnormality of the renal medulla (HP:0100957)2.05144291
124Cerebral edema (HP:0002181)2.04871652
125True hermaphroditism (HP:0010459)2.04775885
126Vertebral fusion (HP:0002948)2.04014556
127Ileus (HP:0002595)2.03848908
128Severe visual impairment (HP:0001141)2.03232900
129Deviation of the thumb (HP:0009603)2.02615368
130Cerebral hypomyelination (HP:0006808)2.02475023
131High anterior hairline (HP:0009890)2.02173389
132Cafe-au-lait spot (HP:0000957)2.01870071
133Pseudobulbar signs (HP:0002200)2.00724099
134Spinal muscular atrophy (HP:0007269)2.00411029
135Gastrointestinal carcinoma (HP:0002672)2.00043659
136Malignant gastrointestinal tract tumors (HP:0006749)2.00043659
137Generalized aminoaciduria (HP:0002909)2.00020979
138Hemivertebrae (HP:0002937)1.99399879
139Optic disc pallor (HP:0000543)1.99227924
140Spastic diplegia (HP:0001264)1.97594773
141Anal stenosis (HP:0002025)1.96845085
142Lactic acidosis (HP:0003128)1.95773056
143Abnormality of the anterior horn cell (HP:0006802)1.95146148
144Degeneration of anterior horn cells (HP:0002398)1.95146148
145Morphological abnormality of the inner ear (HP:0011390)1.94756823
146Glycosuria (HP:0003076)1.93954872
147Abnormality of urine glucose concentration (HP:0011016)1.93954872
148Posterior subcapsular cataract (HP:0007787)1.93681601
1493-Methylglutaconic aciduria (HP:0003535)1.93668626
150Duodenal stenosis (HP:0100867)1.93506555
151Small intestinal stenosis (HP:0012848)1.93506555
152Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.91808470
153Facial hemangioma (HP:0000329)1.91461523
154Sloping forehead (HP:0000340)1.91104101
155Multiple enchondromatosis (HP:0005701)1.89902991
156Tracheoesophageal fistula (HP:0002575)1.88961287
157Abnormality of magnesium homeostasis (HP:0004921)1.88802514
158Increased hepatocellular lipid droplets (HP:0006565)1.87939148
159Nemaline bodies (HP:0003798)1.87741873
160Myopathic facies (HP:0002058)1.87640629
161Anophthalmia (HP:0000528)1.87397860
162Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.86951504
163Vertebral hypoplasia (HP:0008417)1.86951504
164Tongue fasciculations (HP:0001308)1.86876668
165Neoplasm of the pancreas (HP:0002894)1.86800002
166Increased muscle lipid content (HP:0009058)1.84969159
167Paralysis (HP:0003470)1.84553087
168Chorioretinal atrophy (HP:0000533)1.83947475
169Ovarian neoplasm (HP:0100615)1.82703491
170Aplasia/Hypoplasia of the sternum (HP:0006714)1.81116519
171Muscle fibrillation (HP:0010546)1.81112226
172Asplenia (HP:0001746)1.79633493
173Short tibia (HP:0005736)1.79336857
174Abnormal urine output (HP:0012590)1.79098338
175Prominent nose (HP:0000448)1.78766384
176Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78034595
177Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78034595
178Abnormality of the duodenum (HP:0002246)1.77945416
179Proximal tubulopathy (HP:0000114)1.77376551
180Acanthocytosis (HP:0001927)1.77195896
181Rough bone trabeculation (HP:0100670)1.76864628
182Tinnitus (HP:0000360)1.76477932
183Scotoma (HP:0000575)1.75966674
184Exercise intolerance (HP:0003546)1.75453886
185Renal Fanconi syndrome (HP:0001994)1.74601833
186Absent phalangeal crease (HP:0006109)1.74091624
187Hypoplasia of the pons (HP:0012110)1.73239810
188Aplasia/Hypoplasia of the tibia (HP:0005772)1.71566586
189Enlarged kidneys (HP:0000105)1.71124270
190Respiratory failure (HP:0002878)1.69919296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.09019447
2EPHA24.23303209
3WEE13.71781303
4NEK13.55869449
5TAOK33.30182458
6WNK43.20786994
7TTK3.16776593
8CDC73.06742118
9OBSCN2.93506479
10AKT32.76828744
11BUB12.55204047
12NTRK32.47054006
13FRK2.43326641
14NEK22.40605420
15RPS6KB22.34803513
16PHKG12.15428282
17PHKG22.15428282
18PNCK2.11188553
19CDK72.08871885
20OXSR12.05505487
21TSSK62.03398287
22PLK11.97310911
23ADRBK21.95445277
24NUAK11.92400926
25ICK1.92157078
26BRD41.89281132
27CHEK21.79102804
28TLK11.76658156
29MAP4K21.72770276
30NME11.71422609
31STK161.59035851
32TEC1.53492524
33ATR1.45776508
34LATS21.42779918
35SRPK11.42126355
36ALK1.41163445
37CHEK11.38162540
38STK391.37605563
39PASK1.37097022
40CDK41.33924982
41RAF11.33799759
42MAPK131.33083689
43EEF2K1.27793568
44PIK3CG1.27436174
45PLK31.24032269
46AURKB1.23331494
47AURKA1.23019789
48MUSK1.20879964
49CCNB11.19169096
50KSR21.18956846
51MAPKAPK31.16274911
52RIPK41.14992683
53FLT31.14839236
54STK38L1.13406490
55PDK41.13003952
56PDK31.13003952
57MET1.11340756
58TXK1.10191336
59DYRK31.10064595
60PDK21.10059334
61TYRO31.09821403
62MAP3K81.09517152
63BMPR1B1.08593285
64BRAF1.08394617
65CDK21.07576191
66MTOR1.06575202
67ATM1.04468550
68PRKCI1.01965122
69SCYL21.00325275
70PAK40.99739972
71PIM10.92925092
72ZAK0.92500305
73GRK10.92087654
74TIE10.89751299
75RPS6KA50.89260982
76CSNK1D0.88716771
77STK100.88006812
78MAP3K90.87599348
79CLK10.87415192
80ITK0.86817372
81STK40.85991751
82ACVR1B0.84275905
83PKN20.82450665
84WNK30.82407974
85BRSK20.82201407
86LATS10.81705114
87KSR10.80281008
88EIF2AK10.79019173
89INSRR0.78651852
90CSNK1E0.74758573
91TESK20.73819570
92MAP3K100.73283050
93CDK10.73236486
94VRK10.72751630
95AKT20.72072811
96CDK60.70440366
97DDR20.66027502
98CSNK2A20.64900258
99MAPKAPK50.64452839
100BMX0.64442332
101MAPK110.64136856
102MAP3K20.61212061
103MARK30.61142326
104MKNK20.61096104
105PLK20.59140731
106MATK0.58491740
107MELK0.58415383
108MST40.58320051
109PRKACA0.58176218
110MAP2K60.57873746
111SGK10.56656553
112CSNK1A10.56196655
113MAP3K40.55624771
114ERBB40.55341574
115STK380.54496771
116PKN10.54244461
117MKNK10.54037593
118SGK20.53938543
119BCKDK0.52075634
120MAP3K70.52005298
121PAK10.51743434
122BMPR20.51709261
123DYRK20.50787911
124PRKDC0.50336219
125MAPK140.47666277
126TRPM70.45819786
127TGFBR10.45807992
128GSK3B0.43815591
129PRKCG0.43715275
130ADRBK10.43714310
131MAPK10.43678947
132PRKCQ0.43425774
133CSNK2A10.43053156
134MAP3K60.42689665
135CASK0.41346185
136MAP2K10.40496616
137CDK80.40185133
138EIF2AK30.39627900
139MAPK120.39589589
140WNK10.39521690
141GRK60.39294902
142PDGFRA0.38008890
143STK30.37484834
144MAPK100.36492709
145GRK70.36081817
146PRKG10.35678285
147AKT10.33252307
148NME20.32352041
149PLK40.32160067
150YES10.31730915
151BRSK10.29150880
152GSK3A0.28569355
153PRKAA10.27462374
154PINK10.26946733
155PAK60.26893902
156FGR0.25827463
157DAPK10.25778211

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.69689607
2DNA replication_Homo sapiens_hsa030304.17591102
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.08480671
4RNA transport_Homo sapiens_hsa030133.47110896
5One carbon pool by folate_Homo sapiens_hsa006703.30284230
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.25346432
7Oxidative phosphorylation_Homo sapiens_hsa001903.25103909
8Olfactory transduction_Homo sapiens_hsa047403.00867399
9Spliceosome_Homo sapiens_hsa030402.94904985
10Phototransduction_Homo sapiens_hsa047442.94671836
11Parkinsons disease_Homo sapiens_hsa050122.84459471
12Base excision repair_Homo sapiens_hsa034102.65232733
13Nucleotide excision repair_Homo sapiens_hsa034202.64028632
14Homologous recombination_Homo sapiens_hsa034402.57646582
15Cell cycle_Homo sapiens_hsa041102.37798311
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.35384253
17Fanconi anemia pathway_Homo sapiens_hsa034602.35072909
18RNA polymerase_Homo sapiens_hsa030202.34333464
19Butanoate metabolism_Homo sapiens_hsa006502.33626661
20Cardiac muscle contraction_Homo sapiens_hsa042602.30190414
21mRNA surveillance pathway_Homo sapiens_hsa030152.25626772
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24515976
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02831353
24Ribosome_Homo sapiens_hsa030101.94401182
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88331249
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.80637097
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77735073
28Biosynthesis of amino acids_Homo sapiens_hsa012301.77675228
29Non-homologous end-joining_Homo sapiens_hsa034501.74690790
30RNA degradation_Homo sapiens_hsa030181.70803696
31Alzheimers disease_Homo sapiens_hsa050101.65901786
32Basal transcription factors_Homo sapiens_hsa030221.54770810
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54318358
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54147678
35p53 signaling pathway_Homo sapiens_hsa041151.52127188
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51215663
37Pyrimidine metabolism_Homo sapiens_hsa002401.51139775
38Steroid biosynthesis_Homo sapiens_hsa001001.42225850
39Propanoate metabolism_Homo sapiens_hsa006401.35505961
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33024027
41* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29435434
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.29273449
43Regulation of autophagy_Homo sapiens_hsa041401.25852045
44Fructose and mannose metabolism_Homo sapiens_hsa000511.25376280
45Proteasome_Homo sapiens_hsa030501.18636965
46Systemic lupus erythematosus_Homo sapiens_hsa053221.17866538
47Hippo signaling pathway_Homo sapiens_hsa043901.17245374
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11246427
49Carbon metabolism_Homo sapiens_hsa012001.10368421
50Oocyte meiosis_Homo sapiens_hsa041141.08080388
51Selenocompound metabolism_Homo sapiens_hsa004501.07559718
52Nicotine addiction_Homo sapiens_hsa050331.04931579
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.02172740
54Protein export_Homo sapiens_hsa030601.00661496
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00366495
56Basal cell carcinoma_Homo sapiens_hsa052170.99372686
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99189418
58mTOR signaling pathway_Homo sapiens_hsa041500.98709090
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96578084
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91757413
61Nitrogen metabolism_Homo sapiens_hsa009100.91294941
62Vitamin B6 metabolism_Homo sapiens_hsa007500.90532051
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90267274
64Notch signaling pathway_Homo sapiens_hsa043300.90023802
65Folate biosynthesis_Homo sapiens_hsa007900.90002004
66Retinol metabolism_Homo sapiens_hsa008300.89148403
67Viral carcinogenesis_Homo sapiens_hsa052030.88432633
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86466350
69Peroxisome_Homo sapiens_hsa041460.86414032
70Purine metabolism_Homo sapiens_hsa002300.84434444
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84238309
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84017328
73Ether lipid metabolism_Homo sapiens_hsa005650.81595571
74MicroRNAs in cancer_Homo sapiens_hsa052060.81479747
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80212471
76Taste transduction_Homo sapiens_hsa047420.79082058
77Fatty acid elongation_Homo sapiens_hsa000620.78871764
78Lysine degradation_Homo sapiens_hsa003100.76406844
79Hedgehog signaling pathway_Homo sapiens_hsa043400.75714005
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75288528
81Tight junction_Homo sapiens_hsa045300.74979809
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74484018
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.73415665
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70897966
85Collecting duct acid secretion_Homo sapiens_hsa049660.70564214
86TGF-beta signaling pathway_Homo sapiens_hsa043500.70278821
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.69804376
88Pentose phosphate pathway_Homo sapiens_hsa000300.69800162
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69049423
90Adherens junction_Homo sapiens_hsa045200.68487377
91Fatty acid metabolism_Homo sapiens_hsa012120.67694564
92Epstein-Barr virus infection_Homo sapiens_hsa051690.67491156
93Fat digestion and absorption_Homo sapiens_hsa049750.67342207
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65525385
95Chemical carcinogenesis_Homo sapiens_hsa052040.64294295
96Galactose metabolism_Homo sapiens_hsa000520.62295390
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.62129237
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62125462
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59696831
100Thyroid cancer_Homo sapiens_hsa052160.56468113
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54743757
102Arginine and proline metabolism_Homo sapiens_hsa003300.54305481
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.53298140
104Arginine biosynthesis_Homo sapiens_hsa002200.52530583
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51453681
106Insulin secretion_Homo sapiens_hsa049110.51434664
107Caffeine metabolism_Homo sapiens_hsa002320.50184346
108Alcoholism_Homo sapiens_hsa050340.49708983
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48853501
110Bladder cancer_Homo sapiens_hsa052190.47720487
111HTLV-I infection_Homo sapiens_hsa051660.47043733
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43130749
113Type II diabetes mellitus_Homo sapiens_hsa049300.43048136
114Tryptophan metabolism_Homo sapiens_hsa003800.41917526
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41794348
116Colorectal cancer_Homo sapiens_hsa052100.40922474
117Morphine addiction_Homo sapiens_hsa050320.40006006
118Glutathione metabolism_Homo sapiens_hsa004800.39313232
119Arachidonic acid metabolism_Homo sapiens_hsa005900.38668509
120Herpes simplex infection_Homo sapiens_hsa051680.38424087
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36622632
122Primary immunodeficiency_Homo sapiens_hsa053400.36376138
123Dorso-ventral axis formation_Homo sapiens_hsa043200.35469128
124Pathways in cancer_Homo sapiens_hsa052000.35441311
125HIF-1 signaling pathway_Homo sapiens_hsa040660.34795433
126Wnt signaling pathway_Homo sapiens_hsa043100.34704768
127Sulfur relay system_Homo sapiens_hsa041220.33759384
128Calcium signaling pathway_Homo sapiens_hsa040200.32100908
129Small cell lung cancer_Homo sapiens_hsa052220.29306106
130ABC transporters_Homo sapiens_hsa020100.27113973
131Starch and sucrose metabolism_Homo sapiens_hsa005000.26820741
132AMPK signaling pathway_Homo sapiens_hsa041520.26774037
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25093418
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.24913614
135Serotonergic synapse_Homo sapiens_hsa047260.24436438
136Fatty acid biosynthesis_Homo sapiens_hsa000610.21318899
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21205224
138Antigen processing and presentation_Homo sapiens_hsa046120.21106953
139Melanoma_Homo sapiens_hsa052180.19527120
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16239363
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16161941
142Pyruvate metabolism_Homo sapiens_hsa006200.15934611
143Inositol phosphate metabolism_Homo sapiens_hsa005620.14523761
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13353970
145Linoleic acid metabolism_Homo sapiens_hsa005910.12874763
146Glucagon signaling pathway_Homo sapiens_hsa049220.10681202
147Metabolic pathways_Homo sapiens_hsa011000.08373527
148Huntingtons disease_Homo sapiens_hsa050160.08186194
149Proteoglycans in cancer_Homo sapiens_hsa052050.05495579
150Endometrial cancer_Homo sapiens_hsa052130.05260073
151Prostate cancer_Homo sapiens_hsa052150.03281121
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03168953
153Apoptosis_Homo sapiens_hsa042100.02636198
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.00503827

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