ESRRG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.38778479
2negative regulation of cytosolic calcium ion concentration (GO:0051481)6.14433322
3detection of light stimulus involved in visual perception (GO:0050908)5.71515706
4detection of light stimulus involved in sensory perception (GO:0050962)5.71515706
5sodium ion export (GO:0071436)5.62212464
6synaptic vesicle exocytosis (GO:0016079)5.42214680
7cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.29878680
8protein localization to synapse (GO:0035418)5.27748625
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.15000176
10cellular potassium ion homeostasis (GO:0030007)4.93132330
11cell communication by electrical coupling (GO:0010644)4.81694484
12retinal rod cell development (GO:0046548)4.57485366
13gamma-aminobutyric acid signaling pathway (GO:0007214)4.57149642
14G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.51832815
15potassium ion homeostasis (GO:0055075)4.47066279
16retinal cone cell development (GO:0046549)4.23684970
17vocalization behavior (GO:0071625)4.18984107
18exploration behavior (GO:0035640)4.18633259
19synaptic vesicle endocytosis (GO:0048488)4.18323739
20striatum development (GO:0021756)4.13186339
21regulation of short-term neuronal synaptic plasticity (GO:0048172)4.11030746
22regulation of synaptic vesicle exocytosis (GO:2000300)4.07417047
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.05064719
24innervation (GO:0060384)3.84750968
25synaptic vesicle maturation (GO:0016188)3.83126030
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.80890237
27positive regulation of synapse maturation (GO:0090129)3.80393118
28regulation of synapse structural plasticity (GO:0051823)3.75817742
29regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.74876556
30membrane depolarization during action potential (GO:0086010)3.73844123
31cellular sodium ion homeostasis (GO:0006883)3.68265664
32positive regulation of potassium ion transmembrane transport (GO:1901381)3.67015230
33positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.65464011
34positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.64263987
35cell communication involved in cardiac conduction (GO:0086065)3.62594675
36glutamate secretion (GO:0014047)3.62049606
37regulation of synaptic vesicle transport (GO:1902803)3.57744700
38neurotransmitter secretion (GO:0007269)3.57563598
39pyrimidine nucleobase catabolic process (GO:0006208)3.53643193
40regulation of membrane repolarization (GO:0060306)3.52688021
41gamma-aminobutyric acid transport (GO:0015812)3.51307529
42regulation of voltage-gated calcium channel activity (GO:1901385)3.48478041
43potassium ion import (GO:0010107)3.48016794
44cerebellar Purkinje cell differentiation (GO:0021702)3.47598317
45membrane hyperpolarization (GO:0060081)3.47399911
46regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.46848609
47relaxation of smooth muscle (GO:0044557)3.46497386
48calcium ion import (GO:0070509)3.39727686
49prepulse inhibition (GO:0060134)3.39009363
50regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.33750366
51regulation of cell communication by electrical coupling (GO:0010649)3.30135784
52relaxation of cardiac muscle (GO:0055119)3.28547092
53eye photoreceptor cell development (GO:0042462)3.27865685
54regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.27097479
55potassium ion export (GO:0071435)3.25756532
56neuron cell-cell adhesion (GO:0007158)3.25421021
57photoreceptor cell development (GO:0042461)3.25398803
58long-term synaptic potentiation (GO:0060291)3.25194358
59mating behavior (GO:0007617)3.24756377
60neuronal action potential propagation (GO:0019227)3.23285698
61sialylation (GO:0097503)3.20380715
62glutamate receptor signaling pathway (GO:0007215)3.19254828
63regulation of relaxation of muscle (GO:1901077)3.18449564
64cellular potassium ion transport (GO:0071804)3.16564392
65potassium ion transmembrane transport (GO:0071805)3.16564392
66neurotransmitter transport (GO:0006836)3.14973961
67nucleobase catabolic process (GO:0046113)3.13605768
68atrial cardiac muscle cell action potential (GO:0086014)3.13485535
69establishment of synaptic vesicle localization (GO:0097480)3.12372612
70synaptic vesicle transport (GO:0048489)3.12372612
71positive regulation of potassium ion transport (GO:0043268)3.08529566
72regulation of action potential (GO:0098900)3.07853451
73detection of calcium ion (GO:0005513)3.07608296
74synapse assembly (GO:0007416)3.06983621
75positive regulation of action potential (GO:0045760)3.05411857
76neuronal action potential (GO:0019228)3.02540460
77ionotropic glutamate receptor signaling pathway (GO:0035235)3.02464390
78positive regulation of sodium ion transmembrane transport (GO:1902307)3.01733311
79synaptic vesicle docking involved in exocytosis (GO:0016081)3.01389535
80regulation of synapse maturation (GO:0090128)3.00805771
81establishment of protein localization to Golgi (GO:0072600)2.98289552
82response to histamine (GO:0034776)2.97751649
83presynaptic membrane assembly (GO:0097105)2.97411194
84regulation of glutamate receptor signaling pathway (GO:1900449)2.96346593
85regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.96137589
86cell migration in hindbrain (GO:0021535)2.95821165
87regulation of sarcomere organization (GO:0060297)2.94595845
88regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.94416580
89neuroblast proliferation (GO:0007405)2.92933173
90membrane repolarization (GO:0086009)2.91900406
91presynaptic membrane organization (GO:0097090)2.89141919
92regulation of heart rate by cardiac conduction (GO:0086091)2.88712386
93potassium ion transport (GO:0006813)2.86084307
94protein targeting to Golgi (GO:0000042)2.84987423
95positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.84830477
96neuron-neuron synaptic transmission (GO:0007270)2.84756617
97regulation of neurotransmitter secretion (GO:0046928)2.84491675
98serotonin metabolic process (GO:0042428)2.83991519
99behavioral response to nicotine (GO:0035095)2.83446020
100inner ear receptor stereocilium organization (GO:0060122)2.82878286
101cardiac muscle cell action potential (GO:0086001)2.81238701
102righting reflex (GO:0060013)2.81044480
103locomotory exploration behavior (GO:0035641)2.80347838
104behavioral response to ethanol (GO:0048149)2.79912189
105myofibril assembly (GO:0030239)2.77479034
106positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.77381157
107rhodopsin mediated signaling pathway (GO:0016056)2.76908513
108dendrite morphogenesis (GO:0048813)2.76601192
109auditory receptor cell stereocilium organization (GO:0060088)2.76433499
110apical protein localization (GO:0045176)2.75368043
111auditory behavior (GO:0031223)2.75367728
112synaptic transmission, glutamatergic (GO:0035249)2.74451184
113positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.73723800
114action potential (GO:0001508)2.72481308
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.71904881
116synapse organization (GO:0050808)2.71395445
117cardiac myofibril assembly (GO:0055003)2.71185279
118axon cargo transport (GO:0008088)2.70498529
119protein localization to cilium (GO:0061512)2.70414005
120cardiac conduction (GO:0061337)2.69949137
121dendritic spine morphogenesis (GO:0060997)2.69936016
122primary amino compound metabolic process (GO:1901160)2.69329163
123behavioral response to cocaine (GO:0048148)2.69257769
124reflex (GO:0060004)2.68934381
125photoreceptor cell maintenance (GO:0045494)2.68715011
126cardiac muscle contraction (GO:0060048)2.68691586
127regulation of neurotransmitter transport (GO:0051588)2.68026316
128nonmotile primary cilium assembly (GO:0035058)2.67542825
129cerebellar granule cell differentiation (GO:0021707)2.67235375
130neurotransmitter-gated ion channel clustering (GO:0072578)2.67039954
131negative regulation of hormone biosynthetic process (GO:0032353)2.66948576
132synaptic transmission (GO:0007268)2.65884314
133retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62919406
134detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62257180
135negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.61661937
136glycosphingolipid biosynthetic process (GO:0006688)2.59712744
137sarcoplasmic reticulum calcium ion transport (GO:0070296)2.59380878
138neurofilament cytoskeleton organization (GO:0060052)2.57105284
139proline transport (GO:0015824)2.55240948
140postsynaptic membrane organization (GO:0001941)2.55094325
141neuromuscular synaptic transmission (GO:0007274)2.53529713
142regulation of actin filament-based movement (GO:1903115)2.50802697
143positive regulation of sodium ion transport (GO:0010765)2.50630512
144otic vesicle formation (GO:0030916)2.50407787
145cardiac muscle hypertrophy (GO:0003300)2.49355093
146adult heart development (GO:0007512)2.45059014
147short-term memory (GO:0007614)2.44739163
148regulation of sodium ion transmembrane transporter activity (GO:2000649)2.44300785
149nephron tubule morphogenesis (GO:0072078)2.44071512
150nephron epithelium morphogenesis (GO:0072088)2.44071512
151striated muscle hypertrophy (GO:0014897)2.41854087
152startle response (GO:0001964)2.40802493
153protein localization to Golgi apparatus (GO:0034067)2.40652357
154axonal fasciculation (GO:0007413)2.39403155
155multicellular organismal signaling (GO:0035637)2.39179306
156renal tubule morphogenesis (GO:0061333)2.37595888
157sympathetic nervous system development (GO:0048485)2.37376756
158synaptic transmission, cholinergic (GO:0007271)2.35807545
159cardiac chamber formation (GO:0003207)2.34256058
160protein polyglutamylation (GO:0018095)2.33590240
161spinal cord motor neuron differentiation (GO:0021522)2.32551548
162mechanosensory behavior (GO:0007638)2.32038760
163regulation of secondary heart field cardioblast proliferation (GO:0003266)2.30985437
164regulation of cardioblast proliferation (GO:0003264)2.30985437
165sarcomere organization (GO:0045214)2.30522189
166kidney morphogenesis (GO:0060993)2.30189543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.59101411
2EZH2_22144423_ChIP-Seq_EOC_Human3.18851360
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.96096878
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74827721
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67533203
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58391809
7REST_21632747_ChIP-Seq_MESCs_Mouse2.57758684
8DROSHA_22980978_ChIP-Seq_HELA_Human2.53928390
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42832515
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39776241
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.38650386
12* EZH2_27294783_Chip-Seq_ESCs_Mouse2.37618368
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36247342
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35944997
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35944997
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29832996
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29335611
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25177021
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13531524
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.07150192
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06293317
22* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02614105
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.00319618
24AR_21572438_ChIP-Seq_LNCaP_Human1.96566528
25* RNF2_27304074_Chip-Seq_ESCs_Mouse1.96493319
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94897508
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89940112
28* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88973628
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81250746
30IGF1R_20145208_ChIP-Seq_DFB_Human1.80863010
31* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79837585
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.78718745
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.75633858
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71444205
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.68137204
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.65379416
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64928095
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64861588
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62866684
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.62455208
41* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60198541
42* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.59131249
43BCAT_22108803_ChIP-Seq_LS180_Human1.52410200
44* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52288335
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48314458
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48172120
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47713217
48EWS_26573619_Chip-Seq_HEK293_Human1.46306433
49RNF2_27304074_Chip-Seq_NSC_Mouse1.46234727
50* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45689700
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42935928
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.41641724
53* ER_23166858_ChIP-Seq_MCF-7_Human1.40461739
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.40438720
55AR_19668381_ChIP-Seq_PC3_Human1.39767085
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39065649
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.38124134
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.36917324
59AR_25329375_ChIP-Seq_VCAP_Human1.34423037
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.33647650
61ZNF274_21170338_ChIP-Seq_K562_Hela1.33248572
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32969890
63* NANOG_18555785_Chip-Seq_ESCs_Mouse1.32948114
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32865642
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32184037
66P300_19829295_ChIP-Seq_ESCs_Human1.29890365
67* EZH2_27294783_Chip-Seq_NPCs_Mouse1.28993375
68* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27839574
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27793184
70* NFE2_27457419_Chip-Seq_LIVER_Mouse1.26651954
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25604261
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23979441
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23882964
74* RUNX2_22187159_ChIP-Seq_PCA_Human1.21946774
75* RING1B_27294783_Chip-Seq_ESCs_Mouse1.21290440
76TCF4_22108803_ChIP-Seq_LS180_Human1.19738649
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19707940
78* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19202621
79TAF15_26573619_Chip-Seq_HEK293_Human1.19181056
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18849924
81* P53_22387025_ChIP-Seq_ESCs_Mouse1.18668262
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17748644
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17323127
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16639540
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15327230
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14669156
87CBP_20019798_ChIP-Seq_JUKART_Human1.14669156
88* STAT3_23295773_ChIP-Seq_U87_Human1.14411020
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13893560
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.13614425
91* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13542471
92* E2F1_18555785_Chip-Seq_ESCs_Mouse1.13540589
93* SMAD4_21741376_ChIP-Seq_HESCs_Human1.13343073
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13108007
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12792212
96* TCF4_23295773_ChIP-Seq_U87_Human1.12681317
97* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12555498
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12326460
99* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12165753
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11875906
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.11377781
102SMAD3_21741376_ChIP-Seq_HESCs_Human1.10960193
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10364537
104NANOG_19829295_ChIP-Seq_ESCs_Human1.09490821
105SOX2_19829295_ChIP-Seq_ESCs_Human1.09490821
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09307425
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09042299
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08112978
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07106072
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07031110
111* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06971728
112FUS_26573619_Chip-Seq_HEK293_Human1.06252418
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.06130131
114* RING1B_27294783_Chip-Seq_NPCs_Mouse1.03903814
115AHR_22903824_ChIP-Seq_MCF-7_Human1.03554691
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.02715866
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02632951
118* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01968124
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01122028
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99796147
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98658723
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97701592
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97701592
124FLI1_21867929_ChIP-Seq_TH2_Mouse0.96884029
125* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95845372
126CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95510837
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95437554
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95220614
129VDR_22108803_ChIP-Seq_LS180_Human0.94037439
130BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93560648
131KDM2B_26808549_Chip-Seq_REH_Human0.92045310
132* PRDM14_20953172_ChIP-Seq_ESCs_Human0.91981586
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.91220601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog4.32661749
2MP0003195_calcinosis3.18200073
3MP0004859_abnormal_synaptic_plasticity3.07938986
4MP0003880_abnormal_central_pattern3.03485650
5MP0006072_abnormal_retinal_apoptosis2.99219309
6MP0001984_abnormal_olfaction2.92968294
7MP0003635_abnormal_synaptic_transmissio2.76299556
8MP0002090_abnormal_vision2.67849539
9MP0009046_muscle_twitch2.54634072
10MP0001502_abnormal_circadian_rhythm2.40171731
11MP0002064_seizures2.33140204
12MP0000751_myopathy2.31998255
13MP0009745_abnormal_behavioral_response2.29611174
14MP0005253_abnormal_eye_physiology2.27887723
15MP0004782_abnormal_surfactant_physiolog2.26323488
16* MP0004215_abnormal_myocardial_fiber2.26249552
17MP0004145_abnormal_muscle_electrophysio2.25499943
18MP0002102_abnormal_ear_morphology2.25152187
19MP0004233_abnormal_muscle_weight2.24587615
20MP0002063_abnormal_learning/memory/cond2.23905070
21MP0004270_analgesia2.15776898
22MP0004084_abnormal_cardiac_muscle2.13757570
23* MP0001486_abnormal_startle_reflex2.10237625
24MP0005423_abnormal_somatic_nervous2.09674041
25MP0002734_abnormal_mechanical_nocicepti2.07977040
26MP0002272_abnormal_nervous_system2.03513972
27MP0002837_dystrophic_cardiac_calcinosis1.98470773
28MP0002572_abnormal_emotion/affect_behav1.91355287
29MP0003646_muscle_fatigue1.85762817
30MP0001968_abnormal_touch/_nociception1.85399458
31MP0003136_yellow_coat_color1.83282529
32MP0002067_abnormal_sensory_capabilities1.81205240
33MP0004036_abnormal_muscle_relaxation1.76360334
34MP0005195_abnormal_posterior_eye1.69426265
35MP0004043_abnormal_pH_regulation1.65349258
36MP0002184_abnormal_innervation1.63672572
37MP0008569_lethality_at_weaning1.57521214
38MP0005248_abnormal_Harderian_gland1.56018321
39MP0002736_abnormal_nociception_after1.53456458
40MP0000631_abnormal_neuroendocrine_gland1.50974470
41MP0008775_abnormal_heart_ventricle1.50402506
42MP0002638_abnormal_pupillary_reflex1.48198319
43* MP0003137_abnormal_impulse_conducting1.47695020
44MP0005386_behavior/neurological_phenoty1.47168176
45MP0004924_abnormal_behavior1.47168176
46MP0004142_abnormal_muscle_tone1.43269823
47MP0003950_abnormal_plasma_membrane1.41104940
48MP0002229_neurodegeneration1.40792490
49MP0005670_abnormal_white_adipose1.40697107
50MP0002909_abnormal_adrenal_gland1.40674707
51MP0000372_irregular_coat_pigmentation1.40445679
52MP0000778_abnormal_nervous_system1.38429810
53MP0002882_abnormal_neuron_morphology1.36995471
54MP0006292_abnormal_olfactory_placode1.36070736
55MP0005394_taste/olfaction_phenotype1.34212436
56MP0005499_abnormal_olfactory_system1.34212436
57MP0003787_abnormal_imprinting1.34167301
58MP0005620_abnormal_muscle_contractility1.33577317
59MP0004085_abnormal_heartbeat1.33018116
60MP0002557_abnormal_social/conspecific_i1.31812901
61MP0002332_abnormal_exercise_endurance1.31247416
62MP0005645_abnormal_hypothalamus_physiol1.30558686
63MP0001440_abnormal_grooming_behavior1.29637610
64MP0001346_abnormal_lacrimal_gland1.27402892
65MP0002752_abnormal_somatic_nervous1.27157812
66MP0009780_abnormal_chondrocyte_physiolo1.25314806
67MP0001529_abnormal_vocalization1.23712627
68MP0001970_abnormal_pain_threshold1.23120397
69MP0002822_catalepsy1.21894809
70MP0005646_abnormal_pituitary_gland1.21681294
71MP0010386_abnormal_urinary_bladder1.21231515
72MP0006276_abnormal_autonomic_nervous1.20483575
73MP0008877_abnormal_DNA_methylation1.19584305
74MP0000749_muscle_degeneration1.17266541
75MP0001324_abnormal_eye_pigmentation1.15402511
76MP0002751_abnormal_autonomic_nervous1.15154016
77MP0002938_white_spotting1.14629674
78MP0001501_abnormal_sleep_pattern1.13911540
79MP0008004_abnormal_stomach_pH1.13810858
80MP0003011_delayed_dark_adaptation1.13216914
81MP0000955_abnormal_spinal_cord1.13210921
82MP0002066_abnormal_motor_capabilities/c1.12947788
83MP0005330_cardiomyopathy1.12352270
84MP0001485_abnormal_pinna_reflex1.11924818
85MP0002234_abnormal_pharynx_morphology1.11534251
86MP0005187_abnormal_penis_morphology1.06848416
87MP0004811_abnormal_neuron_physiology1.06831841
88MP0005171_absent_coat_pigmentation1.04986493
89MP0003283_abnormal_digestive_organ1.03186837
90MP0001756_abnormal_urination1.01210555
91MP0004885_abnormal_endolymph1.00455749
92MP0002735_abnormal_chemical_nociception0.99062733
93MP0008789_abnormal_olfactory_epithelium0.98356236
94MP0002152_abnormal_brain_morphology0.94654320
95MP0003567_abnormal_fetal_cardiomyocyte0.93948954
96MP0002972_abnormal_cardiac_muscle0.93467871
97MP0001986_abnormal_taste_sensitivity0.93056060
98MP0001188_hyperpigmentation0.92962246
99MP0005367_renal/urinary_system_phenotyp0.92575863
100MP0000516_abnormal_urinary_system0.92575863
101MP0000538_abnormal_urinary_bladder0.91070896
102MP0004133_heterotaxia0.91043943
103* MP0002069_abnormal_eating/drinking_beha0.89940770
104MP0003329_amyloid_beta_deposits0.89322285
105MP0002733_abnormal_thermal_nociception0.88684099
106MP0004742_abnormal_vestibular_system0.87887449
107MP0005595_abnormal_vascular_smooth0.87731524
108MP0002876_abnormal_thyroid_physiology0.87296217
109MP0008961_abnormal_basal_metabolism0.87088638
110MP0004147_increased_porphyrin_level0.86221508
111MP0004087_abnormal_muscle_fiber0.86043557
112MP0001299_abnormal_eye_distance/0.85795912
113MP0000026_abnormal_inner_ear0.85671009
114MP0002127_abnormal_cardiovascular_syste0.85667514
115MP0003122_maternal_imprinting0.85226546
116MP0003879_abnormal_hair_cell0.85220039
117MP0003633_abnormal_nervous_system0.84917236
118MP0000747_muscle_weakness0.84182656
119MP0004484_altered_response_of0.83884562
120MP0003634_abnormal_glial_cell0.83558438
121MP0000569_abnormal_digit_pigmentation0.82554686
122MP0008872_abnormal_physiological_respon0.82484410
123MP0005369_muscle_phenotype0.82414406
124MP0002106_abnormal_muscle_physiology0.78888702
125MP0005085_abnormal_gallbladder_physiolo0.77912188
126MP0001963_abnormal_hearing_physiology0.77093606
127MP0002653_abnormal_ependyma_morphology0.72163712
128MP0005391_vision/eye_phenotype0.71777944
129MP0000230_abnormal_systemic_arterial0.70550499

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)9.43573964
2Central scotoma (HP:0000603)7.62744357
3Abnormality of macular pigmentation (HP:0008002)6.10945368
4Septo-optic dysplasia (HP:0100842)5.13071587
5Scotoma (HP:0000575)5.08171554
6Febrile seizures (HP:0002373)4.87198635
7Severe visual impairment (HP:0001141)4.48443773
8Epileptic encephalopathy (HP:0200134)4.32587509
9Abnormal rod and cone electroretinograms (HP:0008323)4.19253460
10Visual hallucinations (HP:0002367)3.86155193
11Increased circulating renin level (HP:0000848)3.79259423
12Progressive cerebellar ataxia (HP:0002073)3.73204389
13Focal motor seizures (HP:0011153)3.70966290
14Prolonged QT interval (HP:0001657)3.63968807
15Myokymia (HP:0002411)3.50987999
16Decreased central vision (HP:0007663)3.49906184
17Absence seizures (HP:0002121)3.46113423
18Ventricular fibrillation (HP:0001663)3.27631947
19Exercise-induced myalgia (HP:0003738)3.25809694
20Bony spicule pigmentary retinopathy (HP:0007737)3.20648394
21Polydipsia (HP:0001959)3.09876840
22Abnormal drinking behavior (HP:0030082)3.09876840
23Hypomagnesemia (HP:0002917)3.09298759
24Action tremor (HP:0002345)3.06051658
25Focal seizures (HP:0007359)3.05945072
26Pancreatic cysts (HP:0001737)3.05412426
27Intestinal atresia (HP:0011100)3.02066023
28Atrial fibrillation (HP:0005110)2.99193043
29Dialeptic seizures (HP:0011146)2.88518126
30Dysdiadochokinesis (HP:0002075)2.86886033
31Hypothermia (HP:0002045)2.86162142
32Hyperventilation (HP:0002883)2.85445336
33Polyuria (HP:0000103)2.84322353
34Exercise-induced muscle cramps (HP:0003710)2.83615317
35Primary atrial arrhythmia (HP:0001692)2.81785884
36Syncope (HP:0001279)2.79558028
37Pancreatic fibrosis (HP:0100732)2.76640931
38True hermaphroditism (HP:0010459)2.73865244
39Nephronophthisis (HP:0000090)2.73620240
40Absent septum pellucidum (HP:0001331)2.71144826
41Tetany (HP:0001281)2.69883600
42Increased corneal curvature (HP:0100692)2.65849703
43Keratoconus (HP:0000563)2.65849703
44Mutism (HP:0002300)2.65751777
45Bundle branch block (HP:0011710)2.65592342
46Hypoplasia of the fovea (HP:0007750)2.64796634
47Aplasia/Hypoplasia of the fovea (HP:0008060)2.64796634
48Supraventricular tachycardia (HP:0004755)2.64141083
49Optic nerve hypoplasia (HP:0000609)2.63370805
50Molar tooth sign on MRI (HP:0002419)2.62826573
51Abnormality of midbrain morphology (HP:0002418)2.62826573
52Abnormal EKG (HP:0003115)2.62641338
53Abnormality of the renal medulla (HP:0100957)2.62583260
54Metabolic alkalosis (HP:0200114)2.61613303
55Atonic seizures (HP:0010819)2.61550017
56Depression (HP:0000716)2.58404285
57Pendular nystagmus (HP:0012043)2.57040189
58Genital tract atresia (HP:0001827)2.55890019
59Dyschromatopsia (HP:0007641)2.54933134
60Supraventricular arrhythmia (HP:0005115)2.54011699
61Ankle clonus (HP:0011448)2.53305837
62Albinism (HP:0001022)2.52453648
63Vaginal atresia (HP:0000148)2.49356155
64Hemiparesis (HP:0001269)2.49332029
65Abnormality of renin-angiotensin system (HP:0000847)2.49251449
66Abnormality of the fovea (HP:0000493)2.42462529
67Abnormality of the renal cortex (HP:0011035)2.41587888
68Sudden death (HP:0001699)2.36605704
69Abnormality of the sella turcica (HP:0002679)2.34739062
70Pheochromocytoma (HP:0002666)2.34272336
71Hypokalemic alkalosis (HP:0001949)2.33814848
72Generalized tonic-clonic seizures (HP:0002069)2.32625578
73Tubular atrophy (HP:0000092)2.30487932
74Myoglobinuria (HP:0002913)2.28875586
75Abnormal urine output (HP:0012590)2.28173920
76Large for gestational age (HP:0001520)2.27068915
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.26391569
78Abnormality of the calf musculature (HP:0001430)2.25686339
79Chronic hepatic failure (HP:0100626)2.25159879
80Limb dystonia (HP:0002451)2.24953954
81Congenital sensorineural hearing impairment (HP:0008527)2.22217847
82Abnormality of the septum pellucidum (HP:0007375)2.21703667
83Left ventricular hypertrophy (HP:0001712)2.19816706
84Drooling (HP:0002307)2.19007588
85Excessive salivation (HP:0003781)2.19007588
86Abnormal pancreas size (HP:0012094)2.18857068
87Hyperaldosteronism (HP:0000859)2.18447528
88Gait imbalance (HP:0002141)2.16917317
89Abnormality of magnesium homeostasis (HP:0004921)2.16029324
90Genetic anticipation (HP:0003743)2.14518251
91Anxiety (HP:0000739)2.14508294
92Cholecystitis (HP:0001082)2.14466757
93Abnormal gallbladder physiology (HP:0012438)2.14466757
94Hyperactive renin-angiotensin system (HP:0000841)2.14192114
95Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.13643905
96Hemiplegia (HP:0002301)2.11497064
97Abnormality of renal excretion (HP:0011036)2.09952492
98Dysmetria (HP:0001310)2.08664189
99Chorioretinal atrophy (HP:0000533)2.07288422
100Pigmentary retinal degeneration (HP:0001146)2.07239423
101Attenuation of retinal blood vessels (HP:0007843)2.06459554
102Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03788876
103Proximal tubulopathy (HP:0000114)2.02244113
104Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02174540
105Dysmetric saccades (HP:0000641)2.02165075
106Growth hormone deficiency (HP:0000824)2.01013215
107Decreased circulating renin level (HP:0003351)2.00247357
108Hypokalemia (HP:0002900)1.97934745
109Neuroendocrine neoplasm (HP:0100634)1.97900722
110Cystic liver disease (HP:0006706)1.97033668
111Ventricular arrhythmia (HP:0004308)1.96628130
112Polyphagia (HP:0002591)1.96222560
113Congenital primary aphakia (HP:0007707)1.92467330
114Broad-based gait (HP:0002136)1.92315917
115Poor coordination (HP:0002370)1.92165695
116Ulnar claw (HP:0001178)1.91465887
117Abnormal pupillary function (HP:0007686)1.90128545
118Palpitations (HP:0001962)1.89437608
119Generalized hypopigmentation (HP:0007513)1.88790625
120Abnormal eating behavior (HP:0100738)1.88648020
121Abnormality of vitamin B metabolism (HP:0004340)1.88339479
122Nephrogenic diabetes insipidus (HP:0009806)1.87982005
123Fetal akinesia sequence (HP:0001989)1.87899528
124Calf muscle hypertrophy (HP:0008981)1.86681642
125Double outlet right ventricle (HP:0001719)1.84987596
126Congenital malformation of the right heart (HP:0011723)1.84987596
127Postural instability (HP:0002172)1.82901112
128Photophobia (HP:0000613)1.82648047
129Cone-rod dystrophy (HP:0000548)1.82463228
130Abnormality of the ischium (HP:0003174)1.80941731
131Abnormality of chloride homeostasis (HP:0011422)1.79499249
132Type II diabetes mellitus (HP:0005978)1.78483034
133Abnormality of potassium homeostasis (HP:0011042)1.76882910
134Abnormal social behavior (HP:0012433)1.76723577
135Impaired social interactions (HP:0000735)1.76723577
136Medial flaring of the eyebrow (HP:0010747)1.76531395
137Muscle hypertrophy of the lower extremities (HP:0008968)1.76445460
138Short tibia (HP:0005736)1.76381488
139Gaze-evoked nystagmus (HP:0000640)1.76326042
140Scanning speech (HP:0002168)1.76109264
141Absent speech (HP:0001344)1.75129762
142Gout (HP:0001997)1.74691957
143Renal cortical cysts (HP:0000803)1.74338437
144Abnormality of urine glucose concentration (HP:0011016)1.73980088
145Glycosuria (HP:0003076)1.73980088
146Type II lissencephaly (HP:0007260)1.73751004
147EEG with generalized epileptiform discharges (HP:0011198)1.73420318
148Ketoacidosis (HP:0001993)1.72610350
149Epileptiform EEG discharges (HP:0011182)1.72461659
150Specific learning disability (HP:0001328)1.71467084
151Alacrima (HP:0000522)1.71118001
152Optic disc pallor (HP:0000543)1.70954002
153Status epilepticus (HP:0002133)1.70730178
154Exotropia (HP:0000577)1.69689696
155Abolished electroretinogram (ERG) (HP:0000550)1.69460670
156Unsteady gait (HP:0002317)1.69385437
157Cerebellar dysplasia (HP:0007033)1.68914948
158Abnormality of the corticospinal tract (HP:0002492)1.63459612
159Agitation (HP:0000713)1.63311781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.59849715
2PAK63.51337835
3MAP3K43.14935536
4WNK32.98784368
5PHKG22.80130839
6PHKG12.80130839
7NTRK32.75307415
8MARK12.75192665
9NEK12.61270220
10MAP4K22.29436527
11INSRR2.25952490
12PRPF4B2.25013705
13LMTK22.18174789
14ADRBK22.15504464
15MINK12.14482022
16STK382.11567161
17MAP2K72.09313085
18BMPR1B2.05897419
19GRK71.99827276
20MAP3K91.92584777
21PNCK1.88893060
22OBSCN1.87980301
23PINK11.77674853
24MAP2K41.74442218
25ACVR1B1.72197613
26EPHA41.67977246
27TRIM281.54651287
28TNIK1.52728199
29DYRK1A1.50685975
30KSR11.46834022
31SGK4941.44690807
32SGK2231.44690807
33AKT31.42213323
34OXSR11.39402894
35MAPK131.37905633
36NTRK21.36047530
37CASK1.32591693
38WNK11.27043303
39KSR21.22166727
40WNK41.21873310
41BCR1.20792508
42TAOK21.16074413
43MKNK21.15771546
44PAK31.12803839
45CDK51.12188416
46ZAK1.08758508
47SGK21.08682559
48EPHA31.08397952
49MAP3K71.07043323
50RIPK11.06691426
51CDK81.06468264
52FGFR21.05060518
53PRKCG1.05059102
54CAMKK21.02935582
55CDC42BPA0.99065474
56PRKD30.98627395
57NUAK10.98581039
58CAMKK10.97378044
59TNK20.94308276
60DAPK20.93747983
61PRKAA10.93706259
62PIK3CG0.88376778
63CAMK2A0.87763877
64SGK30.86975950
65MAP3K120.86866345
66CAMK2D0.86605781
67ADRBK10.84012768
68LATS20.82892674
69BCKDK0.81955662
70EIF2AK30.81244520
71LATS10.80993866
72PDK20.78892108
73STK38L0.78000330
74CAMK10.77682669
75TAOK10.75366152
76GRK10.75257497
77CSNK1G10.74611429
78CDK180.73778988
79STK390.72715054
80CDK150.72642754
81GRK50.72153363
82PRKCE0.71754469
83SGK10.71325342
84NME10.70599022
85FER0.70348369
86PIK3CA0.68281497
87CSNK1G20.66813269
88DYRK20.65469636
89PKN10.65289157
90SIK30.65207336
91ROCK10.65026862
92CDK140.64738818
93SIK20.64341758
94CDK11A0.63075079
95DMPK0.62564135
96RPS6KA30.62468954
97PRKCZ0.62249547
98PDK40.61526039
99PDK30.61526039
100ROCK20.61490547
101NLK0.60496968
102MAPK100.59580695
103CDK190.57683517
104STK110.57515933
105PRKACA0.57459258
106PRKACB0.57174191
107PLK20.55504071
108CAMK40.54762918
109ERBB30.54592782
110MARK20.54585113
111CAMK1G0.54193547
112PRKG10.51135196
113PTK2B0.50903362
114MAPK120.50500969
115CDK30.49847868
116PRKCH0.49108129
117UHMK10.48889823
118MYLK0.48888190
119PRKCA0.47067213
120CAMK2G0.45854895
121TAOK30.45430254
122PRKAA20.44687364
123MAP2K60.44269245
124CAMK2B0.43166770
125PRKD20.42906391
126CSNK1G30.42515775
127MUSK0.41397175
128PRKACG0.41351615
129MKNK10.41328473
130CLK10.41083499
131CSNK1A1L0.39288143
132IRAK10.38636642
133CSNK1A10.38085244
134STK30.34303010
135TLK10.33467447
136CSNK1D0.30534410
137MAP2K10.30349062

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.28344153
2Synaptic vesicle cycle_Homo sapiens_hsa047213.21419968
3GABAergic synapse_Homo sapiens_hsa047273.10151977
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.76759871
5Morphine addiction_Homo sapiens_hsa050322.64294473
6Phototransduction_Homo sapiens_hsa047442.52276764
7Cardiac muscle contraction_Homo sapiens_hsa042602.38311959
8Circadian entrainment_Homo sapiens_hsa047132.26648154
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.05607758
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.02078575
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.00688616
12Insulin secretion_Homo sapiens_hsa049111.93865209
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89095004
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86323701
15Olfactory transduction_Homo sapiens_hsa047401.82458436
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76587642
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.75275485
18Cholinergic synapse_Homo sapiens_hsa047251.73945718
19Glutamatergic synapse_Homo sapiens_hsa047241.73030259
20Dilated cardiomyopathy_Homo sapiens_hsa054141.68960058
21Salivary secretion_Homo sapiens_hsa049701.66497581
22Oxytocin signaling pathway_Homo sapiens_hsa049211.56971918
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54714189
24Collecting duct acid secretion_Homo sapiens_hsa049661.54241293
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53223583
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51250109
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50942656
28Renin secretion_Homo sapiens_hsa049241.48476744
29Linoleic acid metabolism_Homo sapiens_hsa005911.45566339
30Dopaminergic synapse_Homo sapiens_hsa047281.45514177
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45205594
32Tryptophan metabolism_Homo sapiens_hsa003801.43393306
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39107652
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35193987
35Circadian rhythm_Homo sapiens_hsa047101.32929783
36Serotonergic synapse_Homo sapiens_hsa047261.32058510
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27525662
38Calcium signaling pathway_Homo sapiens_hsa040201.26579567
39Taste transduction_Homo sapiens_hsa047421.25385827
40Gastric acid secretion_Homo sapiens_hsa049711.24102528
41Type II diabetes mellitus_Homo sapiens_hsa049301.19166556
42Selenocompound metabolism_Homo sapiens_hsa004501.17487474
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16292567
44Ether lipid metabolism_Homo sapiens_hsa005651.15911201
45Protein export_Homo sapiens_hsa030601.15545538
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13405206
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12701558
48Long-term potentiation_Homo sapiens_hsa047201.12021232
49Butanoate metabolism_Homo sapiens_hsa006501.10035107
50Amphetamine addiction_Homo sapiens_hsa050311.08551560
51Fructose and mannose metabolism_Homo sapiens_hsa000511.07908007
52cAMP signaling pathway_Homo sapiens_hsa040241.05826742
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05502216
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00932070
55ABC transporters_Homo sapiens_hsa020100.98536077
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97346298
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96134524
58beta-Alanine metabolism_Homo sapiens_hsa004100.93344581
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92776258
60Biosynthesis of amino acids_Homo sapiens_hsa012300.91738287
61Carbon metabolism_Homo sapiens_hsa012000.91443107
62Cocaine addiction_Homo sapiens_hsa050300.89368894
63Ovarian steroidogenesis_Homo sapiens_hsa049130.88885922
64Long-term depression_Homo sapiens_hsa047300.84924305
65Gap junction_Homo sapiens_hsa045400.82200167
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82005220
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81702409
68Fatty acid biosynthesis_Homo sapiens_hsa000610.80997731
69Peroxisome_Homo sapiens_hsa041460.80707875
70Dorso-ventral axis formation_Homo sapiens_hsa043200.80095454
71Fat digestion and absorption_Homo sapiens_hsa049750.78911827
72Pyruvate metabolism_Homo sapiens_hsa006200.78096977
73Propanoate metabolism_Homo sapiens_hsa006400.77383513
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76607763
75Bile secretion_Homo sapiens_hsa049760.76195258
76Regulation of autophagy_Homo sapiens_hsa041400.72992488
77GnRH signaling pathway_Homo sapiens_hsa049120.72543726
78Caffeine metabolism_Homo sapiens_hsa002320.71594194
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.71261452
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.69725459
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.68740879
82Mineral absorption_Homo sapiens_hsa049780.67441354
83Huntingtons disease_Homo sapiens_hsa050160.67326456
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67281514
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67124949
86Oxidative phosphorylation_Homo sapiens_hsa001900.67019663
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.66452953
88Histidine metabolism_Homo sapiens_hsa003400.65330343
89Glucagon signaling pathway_Homo sapiens_hsa049220.64903709
90Alzheimers disease_Homo sapiens_hsa050100.64532532
91Vibrio cholerae infection_Homo sapiens_hsa051100.64392766
92Retinol metabolism_Homo sapiens_hsa008300.64131893
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63741982
94Arginine and proline metabolism_Homo sapiens_hsa003300.63178706
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62918219
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62855792
97Tight junction_Homo sapiens_hsa045300.61678092
98Pancreatic secretion_Homo sapiens_hsa049720.56136497
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56070440
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55285053
101Glycerolipid metabolism_Homo sapiens_hsa005610.55062870
102mTOR signaling pathway_Homo sapiens_hsa041500.54838557
103Galactose metabolism_Homo sapiens_hsa000520.53095185
104Arginine biosynthesis_Homo sapiens_hsa002200.52765638
105Protein digestion and absorption_Homo sapiens_hsa049740.47058032
106Axon guidance_Homo sapiens_hsa043600.46849679
107Endometrial cancer_Homo sapiens_hsa052130.46843670
108Chemical carcinogenesis_Homo sapiens_hsa052040.45817273
109Nitrogen metabolism_Homo sapiens_hsa009100.45037349
110Parkinsons disease_Homo sapiens_hsa050120.44881399
111ErbB signaling pathway_Homo sapiens_hsa040120.44260656
112PPAR signaling pathway_Homo sapiens_hsa033200.43949329
113MAPK signaling pathway_Homo sapiens_hsa040100.43821135
114Fatty acid metabolism_Homo sapiens_hsa012120.42834267
115Hedgehog signaling pathway_Homo sapiens_hsa043400.42259244
116Estrogen signaling pathway_Homo sapiens_hsa049150.41446067
117AMPK signaling pathway_Homo sapiens_hsa041520.41365312
118Vitamin digestion and absorption_Homo sapiens_hsa049770.40404008
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40015288
120Insulin signaling pathway_Homo sapiens_hsa049100.39413685
121Renal cell carcinoma_Homo sapiens_hsa052110.39279100
122Pentose phosphate pathway_Homo sapiens_hsa000300.39182407
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39124595
124Thyroid hormone synthesis_Homo sapiens_hsa049180.38558331
125HIF-1 signaling pathway_Homo sapiens_hsa040660.38481024
126Choline metabolism in cancer_Homo sapiens_hsa052310.38144441
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37794548
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37408474
129Inositol phosphate metabolism_Homo sapiens_hsa005620.35084435
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33914296
131Fatty acid degradation_Homo sapiens_hsa000710.33691466
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.31210394
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27371096
134Glioma_Homo sapiens_hsa052140.26602051
135Starch and sucrose metabolism_Homo sapiens_hsa005000.26528237

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