ESX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)8.88528494
2deoxyribonucleoside monophosphate metabolic process (GO:0009162)8.68913740
3viral transcription (GO:0019083)7.13809628
4translational termination (GO:0006415)6.81945069
5translational elongation (GO:0006414)5.89456658
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.81748456
7histone H4-K12 acetylation (GO:0043983)5.74562045
8cotranslational protein targeting to membrane (GO:0006613)5.72200175
9protein targeting to ER (GO:0045047)5.70556694
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.50020000
11chaperone-mediated protein transport (GO:0072321)5.49634856
12pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.41397151
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.37008821
14cellular protein complex disassembly (GO:0043624)5.36732146
15protein localization to endoplasmic reticulum (GO:0070972)5.32145407
16regulation of meiosis I (GO:0060631)5.26784581
17heterochromatin organization (GO:0070828)5.22261124
18fusion of sperm to egg plasma membrane (GO:0007342)5.14889013
19piRNA metabolic process (GO:0034587)5.07186392
20viral life cycle (GO:0019058)5.05515883
21deoxyribonucleoside triphosphate metabolic process (GO:0009200)5.04020327
22deoxyribose phosphate biosynthetic process (GO:0046385)5.00031219
232-deoxyribonucleotide biosynthetic process (GO:0009265)5.00031219
24translational initiation (GO:0006413)4.99753747
25pre-miRNA processing (GO:0031054)4.99701785
26ribonucleoprotein complex biogenesis (GO:0022613)4.98753389
27pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.95692023
28rRNA modification (GO:0000154)4.81121375
29nuclear pore complex assembly (GO:0051292)4.75626529
30protein targeting to mitochondrion (GO:0006626)4.75165798
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.73436596
32ribosomal small subunit assembly (GO:0000028)4.72272436
33rRNA processing (GO:0006364)4.66229517
34pyrimidine nucleotide catabolic process (GO:0006244)4.65307872
35nuclear pore organization (GO:0006999)4.63730117
36protein neddylation (GO:0045116)4.61092962
37protein complex disassembly (GO:0043241)4.59641599
38ribosomal large subunit biogenesis (GO:0042273)4.59443833
39translation (GO:0006412)4.58557706
40rRNA metabolic process (GO:0016072)4.51501732
41energy coupled proton transport, down electrochemical gradient (GO:0015985)4.48836606
42ATP synthesis coupled proton transport (GO:0015986)4.48836606
43regulation of posttranscriptional gene silencing (GO:0060147)4.43812996
44regulation of gene silencing by miRNA (GO:0060964)4.43812996
45regulation of gene silencing by RNA (GO:0060966)4.43812996
46cellular component biogenesis (GO:0044085)4.42663025
47spliceosomal snRNP assembly (GO:0000387)4.37158851
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.34700766
49mitochondrial respiratory chain complex I assembly (GO:0032981)4.34700766
50NADH dehydrogenase complex assembly (GO:0010257)4.34700766
51regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.34306930
52macromolecular complex disassembly (GO:0032984)4.25508647
53establishment of protein localization to mitochondrial membrane (GO:0090151)4.25174060
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.24776638
55pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.19227039
56protein localization to mitochondrion (GO:0070585)4.19041444
57protein localization to kinetochore (GO:0034501)4.16246736
58mitochondrial respiratory chain complex assembly (GO:0033108)4.15626184
59synaptonemal complex assembly (GO:0007130)4.13247572
60establishment of protein localization to mitochondrion (GO:0072655)4.13195749
61protein complex biogenesis (GO:0070271)4.12599562
62prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.09683837
63regulation of mitochondrial translation (GO:0070129)4.08855256
64peptidyl-histidine modification (GO:0018202)4.08700095
65establishment of apical/basal cell polarity (GO:0035089)4.06232049
66respiratory electron transport chain (GO:0022904)4.05621540
67transcription elongation from RNA polymerase III promoter (GO:0006385)4.04940038
68termination of RNA polymerase III transcription (GO:0006386)4.04940038
69purine nucleobase biosynthetic process (GO:0009113)4.03875249
70cell wall macromolecule catabolic process (GO:0016998)3.98508481
71cell wall macromolecule metabolic process (GO:0044036)3.98508481
72histone H4-K5 acetylation (GO:0043981)3.96515573
73histone H4-K8 acetylation (GO:0043982)3.96515573
74mitotic sister chromatid segregation (GO:0000070)3.93376204
75male meiosis (GO:0007140)3.91965740
76electron transport chain (GO:0022900)3.91802813
77synaptonemal complex organization (GO:0070193)3.90939085
78uterus development (GO:0060065)3.85811646
79protein targeting to membrane (GO:0006612)3.81316558
80proline biosynthetic process (GO:0006561)3.79940755
81mitotic metaphase plate congression (GO:0007080)3.79906299
82trophectodermal cell differentiation (GO:0001829)3.78625265
83pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.77172750
84plasma membrane fusion (GO:0045026)3.75575823
85purine nucleotide salvage (GO:0032261)3.74415295
86chromatin assembly (GO:0031497)3.73652634
87respiratory chain complex IV assembly (GO:0008535)3.72289863
88nuclear-transcribed mRNA catabolic process (GO:0000956)3.71961468
89pseudouridine synthesis (GO:0001522)3.70828480
90deoxyribonucleotide biosynthetic process (GO:0009263)3.70727948
91rRNA methylation (GO:0031167)3.70328921
92maturation of 5.8S rRNA (GO:0000460)3.68426484
93DNA methylation involved in gamete generation (GO:0043046)3.67797847
94pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.67676490
95regulation of hippo signaling (GO:0035330)3.66767758
96mitotic G1 DNA damage checkpoint (GO:0031571)3.62319999
97nucleobase biosynthetic process (GO:0046112)3.61009056
98oxidative phosphorylation (GO:0006119)3.58899900
99nucleobase-containing small molecule interconversion (GO:0015949)3.57842541
100regulation of translational fidelity (GO:0006450)3.57263392
101mitotic nuclear envelope disassembly (GO:0007077)3.56638407
102gene silencing by RNA (GO:0031047)3.55011332
103inner mitochondrial membrane organization (GO:0007007)3.53091174
104mRNA catabolic process (GO:0006402)3.52891451
105DNA replication-dependent nucleosome assembly (GO:0006335)3.51144757
106DNA replication-dependent nucleosome organization (GO:0034723)3.51144757
107deoxyribonucleotide catabolic process (GO:0009264)3.50164439
108DNA damage response, detection of DNA damage (GO:0042769)3.49864836
109formation of translation preinitiation complex (GO:0001731)3.46303978
110pore complex assembly (GO:0046931)3.43128287
111establishment or maintenance of monopolar cell polarity (GO:0061339)3.42947727
112establishment of monopolar cell polarity (GO:0061162)3.42947727
113sister chromatid segregation (GO:0000819)3.40906777
114embryonic process involved in female pregnancy (GO:0060136)3.39258484
115protein localization to chromosome, centromeric region (GO:0071459)3.36627199
116folic acid metabolic process (GO:0046655)3.35417092
117embryonic skeletal joint morphogenesis (GO:0060272)3.34732289
118negative regulation of RNA splicing (GO:0033119)3.34584258
119rRNA transcription (GO:0009303)3.33193063
120nuclear envelope disassembly (GO:0051081)3.32553709
121membrane disassembly (GO:0030397)3.32553709
122regulation of cilium movement (GO:0003352)3.30863777
123regulation of RNA export from nucleus (GO:0046831)3.27673535
124chromatin remodeling at centromere (GO:0031055)3.27487737
125spliceosomal tri-snRNP complex assembly (GO:0000244)3.26648475
1262-deoxyribonucleotide metabolic process (GO:0009394)3.26163704
127dosage compensation (GO:0007549)3.25612995
128embryonic camera-type eye development (GO:0031076)3.25138040
129deoxyribose phosphate catabolic process (GO:0046386)3.24143911
130transcription from mitochondrial promoter (GO:0006390)3.23407993
131RNA catabolic process (GO:0006401)3.22861034
132mitochondrial transport (GO:0006839)3.22540090
133cullin deneddylation (GO:0010388)3.20187882
134CENP-A containing nucleosome assembly (GO:0034080)3.19079332
135meiotic nuclear division (GO:0007126)3.17716782
136mitotic G1/S transition checkpoint (GO:0044819)3.17425570
137kinetochore assembly (GO:0051382)3.14821585
138negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.13989168
139ncRNA processing (GO:0034470)3.12997753
140G1 DNA damage checkpoint (GO:0044783)3.10159975
141meiotic chromosome segregation (GO:0045132)3.07483345
142mitochondrial DNA metabolic process (GO:0032042)3.07127761
143ATP biosynthetic process (GO:0006754)3.06734098
144somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06037369
145somatic hypermutation of immunoglobulin genes (GO:0016446)3.06037369
146paraxial mesoderm development (GO:0048339)3.05861532
147ribonucleoside triphosphate biosynthetic process (GO:0009201)3.05850454
148pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.03984982
149deoxyribose phosphate metabolic process (GO:0019692)3.03215720
150positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.02348645
151positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.02348645
152positive regulation of mitotic sister chromatid separation (GO:1901970)3.02348645
153regulation of double-strand break repair (GO:2000779)3.01804314
154regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.01618614
155DNA replication checkpoint (GO:0000076)3.00220818
156negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99135246
157intracellular estrogen receptor signaling pathway (GO:0030520)2.98209001
158positive regulation of chromosome segregation (GO:0051984)2.97355412
159regulation of sister chromatid cohesion (GO:0007063)2.97007276
160mRNA cleavage (GO:0006379)2.96116002
161chromosome organization involved in meiosis (GO:0070192)2.94663010
162poly(A)+ mRNA export from nucleus (GO:0016973)2.94601017
163regulation of DNA damage checkpoint (GO:2000001)2.93448945
164histone arginine methylation (GO:0034969)2.93328727
165sex differentiation (GO:0007548)2.93167377
166ribosome biogenesis (GO:0042254)2.91870488
167gene silencing (GO:0016458)2.90683467
168DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.90018655
169oocyte development (GO:0048599)2.89887151
170replication fork processing (GO:0031297)2.89678263
171mRNA transport (GO:0051028)2.87895939
172histone H4-K16 acetylation (GO:0043984)2.85968901
173cell migration involved in gastrulation (GO:0042074)2.83659662
174multicellular organism reproduction (GO:0032504)2.83437507
175regulation of integrin activation (GO:0033623)2.83194433
176regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.82671731
177polarized epithelial cell differentiation (GO:0030859)2.81550853
178microtubule depolymerization (GO:0007019)2.81114333
179maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80697165
180negative regulation of meiosis (GO:0045835)2.80299055
181peptidyl-arginine omega-N-methylation (GO:0035247)2.80036349
182mitotic chromosome condensation (GO:0007076)2.78744102
183DNA duplex unwinding (GO:0032508)2.78085229
184histone H2A monoubiquitination (GO:0035518)2.76357428
185DNA geometric change (GO:0032392)2.74554814
186negative regulation of mRNA processing (GO:0050686)2.73186442
187regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.72648641
188regulation of histone H3-K9 methylation (GO:0051570)2.71779242
189DNA unwinding involved in DNA replication (GO:0006268)2.71608496
190somite rostral/caudal axis specification (GO:0032525)2.71546834
191spindle assembly (GO:0051225)2.70060114
192apoptotic process involved in morphogenesis (GO:0060561)2.69791835
193maturation of SSU-rRNA (GO:0030490)10.7548778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.78905466
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.78905466
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.78905466
4E2F7_22180533_ChIP-Seq_HELA_Human4.57612341
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse4.21399708
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.98368155
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.83197865
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.74211448
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.64413086
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.30868521
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.15849695
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.08873889
13MYC_18555785_ChIP-Seq_MESCs_Mouse3.05899239
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.94934235
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88388164
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.87688791
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.76625685
18DCP1A_22483619_ChIP-Seq_HELA_Human2.56602982
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55837917
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.49955229
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.49642950
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.42475502
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.40848412
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33705986
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.32361359
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24669643
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22269441
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.15098481
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.09139244
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09025008
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06502140
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04225637
33ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.03691003
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98974668
35TCF3_18692474_ChIP-Seq_MESCs_Mouse1.98358121
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96291912
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.94254966
38POU5F1_16518401_ChIP-PET_MESCs_Mouse1.91352852
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90268781
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87709527
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.87340579
42TCF3_18692474_ChIP-Seq_MEFs_Mouse1.87271074
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86158594
44VDR_23849224_ChIP-Seq_CD4+_Human1.85398366
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.84690284
46FOXP3_21729870_ChIP-Seq_TREG_Human1.81970120
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79190653
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.78798436
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78489883
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.78209634
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73298888
52CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.73227737
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.72427161
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71785596
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70145979
56NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.70099188
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68634608
58MYC_22102868_ChIP-Seq_BL_Human1.67247697
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.59752891
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59369657
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57732366
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56593079
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56446550
64* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54778730
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51272842
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50880261
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49098338
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45920837
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44487931
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.42951809
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41856249
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41275429
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39380601
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.38651591
75PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.37827567
76XRN2_22483619_ChIP-Seq_HELA_Human1.37807731
77CIITA_25753668_ChIP-Seq_RAJI_Human1.36414095
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.35659331
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34468324
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31905952
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31652519
82POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.31427746
83SOX2_18692474_ChIP-Seq_MESCs_Mouse1.30966739
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.30664612
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29734614
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28999641
87NANOG_18692474_ChIP-Seq_MESCs_Mouse1.28904275
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28134416
89NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.27279993
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27203174
91TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.27141850
92NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26744814
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24943858
94KDM5A_27292631_Chip-Seq_BREAST_Human1.24929877
95MYC_18940864_ChIP-ChIP_HL60_Human1.24220866
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.23653219
97AR_21909140_ChIP-Seq_LNCAP_Human1.22509189
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22317348
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21799557
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.21072908
101E2F1_21310950_ChIP-Seq_MCF-7_Human1.19396819
102HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19320192
103CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17646481
104CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17195097
105ELK1_19687146_ChIP-ChIP_HELA_Human1.14602379
106ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14060906
107ZNF263_19887448_ChIP-Seq_K562_Human1.13560966
108ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12223901
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.10844716
110FOXP1_21924763_ChIP-Seq_HESCs_Human1.10149067
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10111359
112SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08897182
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08737561
114* NANOG_16518401_ChIP-PET_MESCs_Mouse1.08643976
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08111357
116NANOG_18692474_ChIP-Seq_MEFs_Mouse1.07903170
117RACK7_27058665_Chip-Seq_MCF-7_Human1.07800044
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07263109
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07088376
120EGR1_19374776_ChIP-ChIP_THP-1_Human1.06079149
121TTF2_22483619_ChIP-Seq_HELA_Human1.05739367
122* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05582897
123OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04764875
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04254026
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03143539
126TCF7_22412390_ChIP-Seq_EML_Mouse1.01798714
127CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01204174
128TP53_22127205_ChIP-Seq_IMR90_Human1.00655090
129VDR_21846776_ChIP-Seq_THP-1_Human1.00191970
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99815405
131E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99040410
132KDM2B_26808549_Chip-Seq_DND41_Human0.98734288
133POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98056655
134CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97755707
135E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97201995
136EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96406115
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96400433
138EED_16625203_ChIP-ChIP_MESCs_Mouse0.96239963
139KAP1_27257070_Chip-Seq_ESCs_Mouse0.95838661
140KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95590566
141CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95222882
142NCOR1_26117541_ChIP-Seq_K562_Human0.94812677
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94496295
144CHD1_26751641_Chip-Seq_LNCaP_Human0.93383125
145ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92871300
146* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91253109
147TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90860328
148GABP_19822575_ChIP-Seq_HepG2_Human0.90229673
149YY1_21170310_ChIP-Seq_MESCs_Mouse0.89618944
150ELK3_25401928_ChIP-Seq_HUVEC_Human0.88484427
151LXR_22292898_ChIP-Seq_THP-1_Human0.87754194
152CTCF_26484167_Chip-Seq_Bcells_Mouse0.87322989
153ERG_21242973_ChIP-ChIP_JURKAT_Human0.87196080
154E2F1_17053090_ChIP-ChIP_MCF-7_Human0.86485185
155KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86125337
156SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84396672
157HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82591850
158TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79899805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.96815197
2MP0002160_abnormal_reproductive_system3.96703449
3MP0009053_abnormal_anal_canal3.96220243
4MP0008877_abnormal_DNA_methylation3.78396677
5MP0005187_abnormal_penis_morphology3.60877567
6MP0009379_abnormal_foot_pigmentation3.51941451
7MP0010030_abnormal_orbit_morphology3.32298710
8MP0002653_abnormal_ependyma_morphology3.29140046
9MP0001188_hyperpigmentation3.01009972
10MP0003315_abnormal_perineum_morphology2.92946060
11MP0004957_abnormal_blastocyst_morpholog2.88112013
12MP0000678_abnormal_parathyroid_gland2.87261652
13MP0008995_early_reproductive_senescence2.82602211
14MP0003890_abnormal_embryonic-extraembry2.71413571
15MP0010094_abnormal_chromosome_stability2.50419997
16MP0003111_abnormal_nucleus_morphology2.40368966
17MP0004264_abnormal_extraembryonic_tissu2.38700166
18MP0002163_abnormal_gland_morphology2.32200692
19MP0003119_abnormal_digestive_system2.30056889
20MP0003123_paternal_imprinting2.27484907
21MP0003786_premature_aging2.27451971
22MP0005410_abnormal_fertilization2.25379240
23MP0000049_abnormal_middle_ear2.14489120
24MP0001730_embryonic_growth_arrest2.12975219
25MP0001672_abnormal_embryogenesis/_devel2.09807874
26MP0005380_embryogenesis_phenotype2.09807874
27MP0003077_abnormal_cell_cycle2.09238827
28* MP0004197_abnormal_fetal_growth/weight/2.08302334
29MP0002084_abnormal_developmental_patter2.08061629
30MP0005389_reproductive_system_phenotype2.05242335
31MP0003705_abnormal_hypodermis_morpholog2.03954696
32MP0005623_abnormal_meninges_morphology2.00312029
33MP0005076_abnormal_cell_differentiation1.96686248
34MP0004133_heterotaxia1.94947784
35* MP0002086_abnormal_extraembryonic_tissu1.93068489
36MP0002210_abnormal_sex_determination1.92803931
37MP0003984_embryonic_growth_retardation1.92177113
38MP0004233_abnormal_muscle_weight1.91371855
39MP0001929_abnormal_gametogenesis1.89208128
40MP0002085_abnormal_embryonic_tissue1.88163997
41MP0002234_abnormal_pharynx_morphology1.88070317
42MP0002088_abnormal_embryonic_growth/wei1.88001108
43MP0010352_gastrointestinal_tract_polyps1.87174642
44MP0003121_genomic_imprinting1.85685218
45MP0006036_abnormal_mitochondrial_physio1.83917944
46MP0001145_abnormal_male_reproductive1.82437516
47MP0002277_abnormal_respiratory_mucosa1.81937286
48MP0001697_abnormal_embryo_size1.80514521
49MP0003567_abnormal_fetal_cardiomyocyte1.79843586
50MP0009250_abnormal_appendicular_skeleto1.76824106
51MP0000681_abnormal_thyroid_gland1.76588801
52MP0010368_abnormal_lymphatic_system1.69121685
53MP0009278_abnormal_bone_marrow1.67796661
54MP0003806_abnormal_nucleotide_metabolis1.65972746
55MP0002837_dystrophic_cardiac_calcinosis1.64641026
56MP0000350_abnormal_cell_proliferation1.63799904
57MP0003698_abnormal_male_reproductive1.63331375
58MP0008058_abnormal_DNA_repair1.62260639
59MP0005379_endocrine/exocrine_gland_phen1.54983956
60MP0008932_abnormal_embryonic_tissue1.52044491
61MP0001879_abnormal_lymphatic_vessel1.50005096
62MP0005503_abnormal_tendon_morphology1.49038659
63MP0001293_anophthalmia1.47905188
64MP0000653_abnormal_sex_gland1.47712547
65MP0002938_white_spotting1.47402558
66MP0009697_abnormal_copulation1.45274081
67MP0003693_abnormal_embryo_hatching1.41799344
68MP0002697_abnormal_eye_size1.40610641
69MP0002080_prenatal_lethality1.36757001
70MP0003283_abnormal_digestive_organ1.35399737
71MP0003935_abnormal_craniofacial_develop1.28133024
72MP0000534_abnormal_ureter_morphology1.27632389
73MP0009333_abnormal_splenocyte_physiolog1.27096989
74MP0003878_abnormal_ear_physiology1.25665936
75MP0005377_hearing/vestibular/ear_phenot1.25665936
76MP0003122_maternal_imprinting1.25350029
77MP0001881_abnormal_mammary_gland1.23764289
78MP0010307_abnormal_tumor_latency1.21367958
79MP0000432_abnormal_head_morphology1.20701618
80MP0004782_abnormal_surfactant_physiolog1.20672891
81MP0008007_abnormal_cellular_replicative1.15780186
82MP0001764_abnormal_homeostasis1.15699892
83MP0002249_abnormal_larynx_morphology1.13536427
84MP0002092_abnormal_eye_morphology1.12491620
85MP0001270_distended_abdomen1.11493688
86MP0003279_aneurysm1.10608173
87MP0002111_abnormal_tail_morphology1.08093902
88MP0002161_abnormal_fertility/fecundity1.06018867
89MP0003937_abnormal_limbs/digits/tail_de1.05811644
90MP0003755_abnormal_palate_morphology1.05044607
91MP0005670_abnormal_white_adipose1.04581549
92MP0003936_abnormal_reproductive_system1.04089778
93MP0003186_abnormal_redox_activity1.03199763
94MP0002796_impaired_skin_barrier1.02744072
95MP0004858_abnormal_nervous_system0.98529934
96MP0003115_abnormal_respiratory_system0.97396538
97MP0003861_abnormal_nervous_system0.97144410
98MP0003941_abnormal_skin_development0.96616385
99MP0002114_abnormal_axial_skeleton0.95658068
100MP0005646_abnormal_pituitary_gland0.95168168
101MP0003453_abnormal_keratinocyte_physiol0.90394412
102MP0005171_absent_coat_pigmentation0.89822067
103MP0001915_intracranial_hemorrhage0.89371173
104MP0002932_abnormal_joint_morphology0.89054555
105MP0002925_abnormal_cardiovascular_devel0.89027899
106MP0000313_abnormal_cell_death0.88900302
107MP0000490_abnormal_crypts_of0.88869584
108MP0004272_abnormal_basement_membrane0.86813137
109MP0000537_abnormal_urethra_morphology0.86582593
110MP0002269_muscular_atrophy0.86575574
111MP0001849_ear_inflammation0.85822071
112MP0009703_decreased_birth_body0.85098973
113MP0001346_abnormal_lacrimal_gland0.84653169
114MP0003385_abnormal_body_wall0.84348735
115MP0004808_abnormal_hematopoietic_stem0.83704268
116MP0001661_extended_life_span0.83371816
117MP0006035_abnormal_mitochondrial_morpho0.82987094
118MP0002009_preneoplasia0.80799887
119MP0002116_abnormal_craniofacial_bone0.80764748
120MP0000538_abnormal_urinary_bladder0.79710660
121MP0000428_abnormal_craniofacial_morphol0.79656269
122MP0002177_abnormal_outer_ear0.79041903
123MP0001727_abnormal_embryo_implantation0.78917749
124MP0005501_abnormal_skin_physiology0.78672739
125MP0005508_abnormal_skeleton_morphology0.78039530
126MP0008873_increased_physiological_sensi0.77951181
127MP0000750_abnormal_muscle_regeneration0.77499118
128MP0003566_abnormal_cell_adhesion0.76963004
129MP0000762_abnormal_tongue_morphology0.73422956
130MP0000647_abnormal_sebaceous_gland0.73225233
131MP0003011_delayed_dark_adaptation0.71473975
132MP0002019_abnormal_tumor_incidence0.71423005
133MP0002127_abnormal_cardiovascular_syste0.70892782
134MP0003942_abnormal_urinary_system0.69204878
135MP0005647_abnormal_sex_gland0.68201765
136MP0005391_vision/eye_phenotype0.67765627
137MP0000749_muscle_degeneration0.67463376
138MP0005266_abnormal_metabolism0.67454048
139MP0002877_abnormal_melanocyte_morpholog0.67159205
140MP0001286_abnormal_eye_development0.66457498
141MP0008770_decreased_survivor_rate0.65702036
142MP0006292_abnormal_olfactory_placode0.65342662
143MP0003938_abnormal_ear_development0.65240076
144MP0003943_abnormal_hepatobiliary_system0.65203296
145MP0002282_abnormal_trachea_morphology0.65070765
146MP0006072_abnormal_retinal_apoptosis0.65008042
147MP0005220_abnormal_exocrine_pancreas0.61315176
148MP0001119_abnormal_female_reproductive0.60492442
149MP0000767_abnormal_smooth_muscle0.60039331
150MP0000372_irregular_coat_pigmentation0.59510788
151MP0002109_abnormal_limb_morphology0.59099464
152MP0000627_abnormal_mammary_gland0.58931098

Predicted human phenotypes

RankGene SetZ-score
1Decreased activity of mitochondrial respiratory chain (HP:0008972)6.16043884
2Abnormal activity of mitochondrial respiratory chain (HP:0011922)6.16043884
33-Methylglutaconic aciduria (HP:0003535)5.68729494
4Short middle phalanx of the 5th finger (HP:0004220)5.19438183
5Aplastic anemia (HP:0001915)5.13475206
6Broad distal phalanx of finger (HP:0009836)5.04878302
7Annular pancreas (HP:0001734)5.03487148
8Muscle fibrillation (HP:0010546)4.29690571
9Supernumerary spleens (HP:0009799)4.27233767
10Microvesicular hepatic steatosis (HP:0001414)4.16910335
11Tongue fasciculations (HP:0001308)4.16426795
12Abnormal mitochondria in muscle tissue (HP:0008316)4.06714275
13Intestinal atresia (HP:0011100)4.05666982
14Rib fusion (HP:0000902)3.91801270
15Acute necrotizing encephalopathy (HP:0006965)3.85304727
16Mitochondrial inheritance (HP:0001427)3.81947159
17Abnormality of the fetal cardiovascular system (HP:0010948)3.81690413
18Abnormal umbilical cord blood vessels (HP:0011403)3.81690413
19Single umbilical artery (HP:0001195)3.81690413
20Increased CSF lactate (HP:0002490)3.65214490
21Hepatocellular necrosis (HP:0001404)3.64379107
22Abnormality of the lower motor neuron (HP:0002366)3.61525552
23Hepatic necrosis (HP:0002605)3.57785788
24Ependymoma (HP:0002888)3.55453125
25Macrocytic anemia (HP:0001972)3.55144860
26Esophageal atresia (HP:0002032)3.47227099
27Dysphonia (HP:0001618)3.43520795
28Astrocytoma (HP:0009592)3.43497910
29Abnormality of the astrocytes (HP:0100707)3.43497910
30Double outlet right ventricle (HP:0001719)3.41398472
31Congenital malformation of the right heart (HP:0011723)3.41398472
32Abnormal number of erythroid precursors (HP:0012131)3.34817460
33Transposition of the great arteries (HP:0001669)3.33944089
34Abnormal connection of the cardiac segments (HP:0011545)3.33944089
35Abnormal ventriculo-arterial connection (HP:0011563)3.33944089
36Male infertility (HP:0003251)3.31142971
37Short humerus (HP:0005792)3.22839336
38Ragged-red muscle fibers (HP:0003200)3.22755962
39Selective tooth agenesis (HP:0001592)3.19027654
40Aplasia/hypoplasia of the humerus (HP:0006507)3.17219996
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.14908200
42Generalized aminoaciduria (HP:0002909)3.11074995
43Progressive macrocephaly (HP:0004481)3.10908123
44Impulsivity (HP:0100710)3.10448159
45Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.09417134
46Acute encephalopathy (HP:0006846)3.06230655
47Radial bowing (HP:0002986)3.04507060
48Testicular atrophy (HP:0000029)3.02883211
49Hypoplastic left heart (HP:0004383)3.02590237
50Abnormality of cells of the erythroid lineage (HP:0012130)2.99767378
51Hypochromic microcytic anemia (HP:0004840)2.99285712
52Hypoplasia of the uterus (HP:0000013)2.97482318
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.90959299
54Bilateral microphthalmos (HP:0007633)2.90118322
55Missing ribs (HP:0000921)2.89348340
56Depressed nasal tip (HP:0000437)2.85257031
57Increased serum lactate (HP:0002151)2.83848830
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82885309
59Gout (HP:0001997)2.81567131
60Nausea (HP:0002018)2.78125552
61Rectal fistula (HP:0100590)2.77964617
62Rectovaginal fistula (HP:0000143)2.77964617
63Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.76616732
64Neoplasm of striated muscle (HP:0009728)2.72978848
65Lactic acidosis (HP:0003128)2.72960421
66Aplasia/hypoplasia of the uterus (HP:0008684)2.71506791
67Absent radius (HP:0003974)2.69776921
68Asplenia (HP:0001746)2.69342433
69Short clavicles (HP:0000894)2.68143816
70Respiratory failure (HP:0002878)2.66546734
71Increased intramyocellular lipid droplets (HP:0012240)2.61550484
72Intestinal fistula (HP:0100819)2.60743951
73Glioma (HP:0009733)2.60384464
74Gastrointestinal atresia (HP:0002589)2.59467359
75Progressive muscle weakness (HP:0003323)2.56048411
76Chromsome breakage (HP:0040012)2.55623583
77Nephroblastoma (Wilms tumor) (HP:0002667)2.54872600
78Exercise intolerance (HP:0003546)2.54205982
79Facial hemangioma (HP:0000329)2.53082687
80Abnormality of the phalanges of the 5th finger (HP:0004213)2.52160775
81Aplasia involving forearm bones (HP:0009822)2.51839498
82Absent forearm bone (HP:0003953)2.51839498
83Abnormality of the phalanges of the hallux (HP:0010057)2.51408248
84Abnormality of the umbilical cord (HP:0010881)2.49799899
85Aplasia/Hypoplasia of the clavicles (HP:0006710)2.47169942
86Progressive external ophthalmoplegia (HP:0000590)2.45026866
87Metaphyseal cupping (HP:0003021)2.44167516
88Abnormality of the middle phalanges of the toes (HP:0010183)2.43993497
89Abnormality of the distal phalanges of the toes (HP:0010182)2.42730839
90Shawl scrotum (HP:0000049)2.41040204
91Renal dysplasia (HP:0000110)2.40984721
92Bowed forearm bones (HP:0003956)2.38199577
93Bowing of the arm (HP:0006488)2.38199577
94Cerebral edema (HP:0002181)2.36413426
95Hypoplastic heart (HP:0001961)2.36394112
96Neoplasm of the oral cavity (HP:0100649)2.35375602
97Embryonal renal neoplasm (HP:0011794)2.34961235
98Vaginal fistula (HP:0004320)2.34056428
99Cleft eyelid (HP:0000625)2.32563504
100Occipital encephalocele (HP:0002085)2.32330945
101Ureteral stenosis (HP:0000071)2.32265579
102Increased muscle lipid content (HP:0009058)2.31989055
103Abnormality of the labia minora (HP:0012880)2.31758828
104Rhabdomyosarcoma (HP:0002859)2.31443880
105Concave nail (HP:0001598)2.30959921
106Microretrognathia (HP:0000308)2.30485202
107Medulloblastoma (HP:0002885)2.29689119
108Abnormality of the 4th metacarpal (HP:0010012)2.28400760
109Cerebral hypomyelination (HP:0006808)2.27977246
110Reticulocytopenia (HP:0001896)2.27068300
111Pseudobulbar signs (HP:0002200)2.26827199
112Heterotopia (HP:0002282)2.23800387
113Absent phalangeal crease (HP:0006109)2.23478983
114Renal Fanconi syndrome (HP:0001994)2.23330772
115Absent thumb (HP:0009777)2.22773913
116Truncus arteriosus (HP:0001660)2.17758733
117Abnormality of alanine metabolism (HP:0010916)2.15525136
118Hyperalaninemia (HP:0003348)2.15525136
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15525136
120Abnormal respiratory motile cilium morphology (HP:0005938)2.15440201
121Abnormal respiratory epithelium morphology (HP:0012253)2.15440201
122Hand muscle atrophy (HP:0009130)2.14565215
12311 pairs of ribs (HP:0000878)2.14066875
124Renal duplication (HP:0000075)2.12154195
125Spinal cord lesions (HP:0100561)2.11679643
126Syringomyelia (HP:0003396)2.11679643
127Pallor (HP:0000980)2.10375515
128Abnormality of the ileum (HP:0001549)2.10231644
129Fasciculations (HP:0002380)2.09867390
130Respiratory difficulties (HP:0002880)2.08016273
131Ureteral obstruction (HP:0006000)2.07487475
132Gonadotropin excess (HP:0000837)2.06541301
133Vertebral fusion (HP:0002948)2.06460996
134Unilateral renal agenesis (HP:0000122)2.06347040
135Spinal muscular atrophy (HP:0007269)2.06052160
136Type I transferrin isoform profile (HP:0003642)2.04785808
137Rough bone trabeculation (HP:0100670)2.04423649
138Increased hepatocellular lipid droplets (HP:0006565)2.03526596
139Redundant skin (HP:0001582)2.03422305
140Abnormality of the phalanges of the 2nd finger (HP:0009541)2.03244800
141Cutaneous melanoma (HP:0012056)2.03042217
142Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.02054161
143Hyperthyroidism (HP:0000836)2.01692528
144Ulnar bowing (HP:0003031)2.01420133
145Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00449415
146Patellar aplasia (HP:0006443)2.00342240
147Increased nuchal translucency (HP:0010880)1.98977247
148Recurrent corneal erosions (HP:0000495)1.98906792
149Pancytopenia (HP:0001876)1.98639732
150Multiple enchondromatosis (HP:0005701)1.97959274
151Preauricular pit (HP:0004467)1.95866506
152Periauricular skin pits (HP:0100277)1.95866506
153Esophageal neoplasm (HP:0100751)1.95584422
154Neoplasm of head and neck (HP:0012288)1.95584422
155Volvulus (HP:0002580)1.94943719
156Symphalangism affecting the phalanges of the hand (HP:0009773)1.94026665
157Squamous cell carcinoma (HP:0002860)1.92493955
158Orthostatic hypotension (HP:0001278)1.91714150
159Septate vagina (HP:0001153)1.91541695
160Broad alveolar ridges (HP:0000187)1.89842818
161Skin tags (HP:0010609)1.89511043
162Abnormal number of incisors (HP:0011064)1.88820911
163Upper limb amyotrophy (HP:0009129)1.88559309
164Distal upper limb amyotrophy (HP:0007149)1.88559309
165Premature ovarian failure (HP:0008209)1.86864426
166Supernumerary ribs (HP:0005815)1.86331287
167Megalocornea (HP:0000485)1.85581310
168Abnormality of the aortic arch (HP:0012303)1.85378412
169Abnormal hemoglobin (HP:0011902)1.85281058
170Vertebral clefting (HP:0008428)1.85131813
171Abnormality of the duodenum (HP:0002246)1.84199089
172Preauricular skin tag (HP:0000384)1.84049421
173Anal stenosis (HP:0002025)1.82802583
174Abnormal lung lobation (HP:0002101)1.82746866
175Meckel diverticulum (HP:0002245)1.81057829
176Aplasia/Hypoplasia of the uvula (HP:0010293)1.80708350
177Short 5th finger (HP:0009237)1.79746800
178Aplasia/Hypoplasia of the patella (HP:0006498)1.79355892
179Abnormal sex determination (HP:0012244)1.78454072
180Sex reversal (HP:0012245)1.78454072
181Abnormality of the musculature of the hand (HP:0001421)1.75291425
182Infertility (HP:0000789)1.75263849
183Dynein arm defect of respiratory motile cilia (HP:0012255)1.75076648
184Absent/shortened dynein arms (HP:0200106)1.75076648
185Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.74548194
186Prominent nose (HP:0000448)1.74538807
187Trismus (HP:0000211)1.73758334
188Azoospermia (HP:0000027)1.73132015
189Turricephaly (HP:0000262)1.73125644
190Large earlobe (HP:0009748)1.72956840
191Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72479205
192Fused cervical vertebrae (HP:0002949)1.71865744
193Hypopigmentation of the fundus (HP:0007894)1.68968685

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.74559666
2NME27.54523214
3EIF2AK15.42025332
4ICK4.45446465
5TYRO33.04105688
6CDK72.48098292
7BRD42.37312092
8VRK22.18736029
9DDR22.16583622
10CDC72.16164119
11MAP3K61.98420539
12STK161.83007299
13MATK1.82768347
14BCKDK1.77621719
15TTK1.76760229
16SRPK11.72088481
17RPS6KB21.70307323
18MAP3K101.67674895
19MTOR1.65952202
20SMG11.62263242
21WEE11.58871325
22ABL21.54902735
23EEF2K1.52127008
24BMX1.51766431
25CHEK21.51507501
26LRRK21.50093109
27BRSK11.48574190
28NEK21.45747585
29LATS21.43980242
30PDK31.43468787
31PDK41.43468787
32PLK11.43158061
33IRAK31.42780849
34EPHA21.40649527
35CAMKK21.38576262
36FGR1.35740201
37PDGFRA1.33798027
38CDK81.30601144
39STK41.30376457
40TLK11.30008508
41DYRK21.29674181
42CHEK11.20470698
43RIPK41.20295634
44PLK41.15248401
45PAK41.12595441
46KDR1.12393118
47ILK1.10903829
48STK101.07263019
49CDK61.06114349
50ALK1.03587018
51LATS11.00980219
52GRK61.00517895
53BUB10.99885533
54PRKD30.97012696
55PNCK0.96846902
56RIPK10.96254423
57CDK40.95377068
58AKT30.93701200
59RPS6KA40.93660908
60GRK50.91894020
61PRPF4B0.91118856
62ERN10.90563314
63MAP3K110.88471738
64AKT20.86234100
65CAMK1G0.86053460
66CDK20.85934629
67MET0.85518686
68UHMK10.85071258
69MAPK150.85037981
70BRSK20.83345444
71WNK10.82313538
72ATR0.82024099
73CSK0.81671065
74DYRK1B0.80778464
75TIE10.77930912
76CSNK2A10.75721656
77PRKD20.75459086
78CDK90.74767161
79ATM0.74513358
80LIMK10.73272801
81CCNB10.71942807
82STK30.71361242
83MAPKAPK30.70932567
84ARAF0.69561788
85RPS6KA50.68737775
86DAPK10.68033089
87PTK20.68001138
88MAP3K80.67004721
89VRK10.65480562
90PDK20.64226226
91AURKB0.64045228
92YES10.63938370
93CDC42BPA0.63824391
94AURKA0.61853988
95PIM10.61802106
96TRIB30.60875682
97TAOK20.59776170
98CSNK1E0.59503740
99PAK20.56216227
100CDK10.55927625
101PRKG20.55198432
102DYRK30.54889015
103CSF1R0.53565209
104STK38L0.53335985
105PRKCI0.52731621
106PASK0.52259336
107CDK30.51920399
108CDK11A0.51241073
109MAPK10.51194397
110GSK3A0.50984289
111SCYL20.49843875
112GRK10.49065960
113TSSK60.48864393
114PAK10.48792184
115TESK10.48440765
116CDK150.48192665
117PLK30.47330020
118PDGFRB0.45403710
119CSNK1G30.44766974
120CAMK1D0.44756660
121MAPK140.44426620
122CSNK2A20.42369966
123ADRBK20.42073496
124CDK180.41484464
125NME10.40785642
126TESK20.40701952
127IKBKB0.39563312
128GSK3B0.39227492
129FES0.38349353
130PIM20.38223750
131RPS6KC10.38004481
132RPS6KL10.38004481
133RPS6KA10.37284754
134WNK40.37242336
135TRIM280.36440798
136BRAF0.36339765
137NEK10.35756255
138WNK30.35480751
139MARK20.35297355
140EGFR0.34550392
141CAMK2G0.34324277
142MOS0.34143197
143MAPK70.34122429
144MKNK20.34120227
145TAF10.33941145
146MAPK100.33806974
147MAPKAPK50.33056561
148PTK60.32532067
149AKT10.30892877
150PBK0.30570542
151PRKAA10.29869047
152RPS6KB10.28989602
153CDK140.28201762
154MAPKAPK20.28135092
155INSRR0.27996303
156CSNK1A1L0.25548007
157MAP2K30.25206086
158PRKDC0.24728171
159TYK20.24547513
160CAMK10.24266056
161CSNK1A10.18776088
162MAP3K40.18308399
163MINK10.17822547

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.43942647
2Oxidative phosphorylation_Homo sapiens_hsa001904.08144689
3Parkinsons disease_Homo sapiens_hsa050123.53835341
4RNA transport_Homo sapiens_hsa030133.48661193
5Sulfur relay system_Homo sapiens_hsa041223.09981543
6Mismatch repair_Homo sapiens_hsa034302.99648873
7mRNA surveillance pathway_Homo sapiens_hsa030152.85606788
8DNA replication_Homo sapiens_hsa030302.78070704
9Huntingtons disease_Homo sapiens_hsa050162.71107884
10Spliceosome_Homo sapiens_hsa030402.63763502
11Proteasome_Homo sapiens_hsa030502.59618606
12Fatty acid biosynthesis_Homo sapiens_hsa000612.58743206
13Base excision repair_Homo sapiens_hsa034102.52710384
14Fanconi anemia pathway_Homo sapiens_hsa034602.44256579
15Alzheimers disease_Homo sapiens_hsa050102.36278543
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.32316686
17One carbon pool by folate_Homo sapiens_hsa006702.31001317
18Basal transcription factors_Homo sapiens_hsa030222.27381434
19Cell cycle_Homo sapiens_hsa041102.23349121
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.17868245
21Homologous recombination_Homo sapiens_hsa034401.96715088
22Notch signaling pathway_Homo sapiens_hsa043301.93912255
23Nucleotide excision repair_Homo sapiens_hsa034201.93679385
24p53 signaling pathway_Homo sapiens_hsa041151.88196536
25Hedgehog signaling pathway_Homo sapiens_hsa043401.88097758
26Vitamin B6 metabolism_Homo sapiens_hsa007501.81620713
27Hippo signaling pathway_Homo sapiens_hsa043901.76520266
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.70502364
29Lysine degradation_Homo sapiens_hsa003101.62380011
30Purine metabolism_Homo sapiens_hsa002301.61441020
31RNA polymerase_Homo sapiens_hsa030201.58785962
32Adherens junction_Homo sapiens_hsa045201.55126246
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54255264
34mTOR signaling pathway_Homo sapiens_hsa041501.52692899
35Basal cell carcinoma_Homo sapiens_hsa052171.52050868
36Oocyte meiosis_Homo sapiens_hsa041141.49340071
37Dorso-ventral axis formation_Homo sapiens_hsa043201.43896351
38Cardiac muscle contraction_Homo sapiens_hsa042601.41663302
39Ribosome_Homo sapiens_hsa030101.40671668
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40021352
41Biosynthesis of amino acids_Homo sapiens_hsa012301.37754552
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37371461
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34275881
44* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34128651
45TGF-beta signaling pathway_Homo sapiens_hsa043501.30564060
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22964287
47Tight junction_Homo sapiens_hsa045301.20054511
48Selenocompound metabolism_Homo sapiens_hsa004501.18288014
49RNA degradation_Homo sapiens_hsa030181.13699639
50Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13694255
51Small cell lung cancer_Homo sapiens_hsa052221.09226967
52MicroRNAs in cancer_Homo sapiens_hsa052061.06927669
53Linoleic acid metabolism_Homo sapiens_hsa005911.06390925
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05876296
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04627038
56Wnt signaling pathway_Homo sapiens_hsa043101.04327626
57Thyroid cancer_Homo sapiens_hsa052161.02730402
58Protein export_Homo sapiens_hsa030601.02178537
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96100339
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92229015
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.90312929
62Sulfur metabolism_Homo sapiens_hsa009200.90083771
63Bladder cancer_Homo sapiens_hsa052190.87454475
64Metabolic pathways_Homo sapiens_hsa011000.87412391
65Fructose and mannose metabolism_Homo sapiens_hsa000510.82968140
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82882386
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81837605
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81375551
69Phenylalanine metabolism_Homo sapiens_hsa003600.81275945
70Viral carcinogenesis_Homo sapiens_hsa052030.81071441
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80893297
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79683902
73VEGF signaling pathway_Homo sapiens_hsa043700.79389521
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77658780
75Pyrimidine metabolism_Homo sapiens_hsa002400.77444022
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77055991
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72951711
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.71698870
79Pyruvate metabolism_Homo sapiens_hsa006200.70924441
80Pathways in cancer_Homo sapiens_hsa052000.68761058
81AMPK signaling pathway_Homo sapiens_hsa041520.67114778
82Pentose phosphate pathway_Homo sapiens_hsa000300.66850012
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66337219
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65617537
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62838040
86Arginine and proline metabolism_Homo sapiens_hsa003300.62675654
87Proteoglycans in cancer_Homo sapiens_hsa052050.60970857
88Colorectal cancer_Homo sapiens_hsa052100.58845309
89HTLV-I infection_Homo sapiens_hsa051660.58342255
90Herpes simplex infection_Homo sapiens_hsa051680.58263958
91Galactose metabolism_Homo sapiens_hsa000520.57411623
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56496085
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55809123
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55195982
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.52418843
96Choline metabolism in cancer_Homo sapiens_hsa052310.51308387
97Epstein-Barr virus infection_Homo sapiens_hsa051690.51135605
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.51009980
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.50525126
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48439703
101Focal adhesion_Homo sapiens_hsa045100.44224389
102Acute myeloid leukemia_Homo sapiens_hsa052210.43838762
103ErbB signaling pathway_Homo sapiens_hsa040120.42376327
104Prostate cancer_Homo sapiens_hsa052150.41433595
105ECM-receptor interaction_Homo sapiens_hsa045120.41062936
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40709516
107Arachidonic acid metabolism_Homo sapiens_hsa005900.40532435
108Chronic myeloid leukemia_Homo sapiens_hsa052200.40203100
109Folate biosynthesis_Homo sapiens_hsa007900.39306505
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36730756
111Fatty acid elongation_Homo sapiens_hsa000620.35923388
112Vitamin digestion and absorption_Homo sapiens_hsa049770.33284788
113Prion diseases_Homo sapiens_hsa050200.31461572
114Inositol phosphate metabolism_Homo sapiens_hsa005620.31030863
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29421537
116Carbon metabolism_Homo sapiens_hsa012000.28605348
117Estrogen signaling pathway_Homo sapiens_hsa049150.28233744
118Rap1 signaling pathway_Homo sapiens_hsa040150.28114267
119Tyrosine metabolism_Homo sapiens_hsa003500.27529922
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27184244
121Melanoma_Homo sapiens_hsa052180.26810696
122Vibrio cholerae infection_Homo sapiens_hsa051100.26742111
123N-Glycan biosynthesis_Homo sapiens_hsa005100.26622401
124Glucagon signaling pathway_Homo sapiens_hsa049220.26522954
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25873359
126Endometrial cancer_Homo sapiens_hsa052130.25578978
127Ovarian steroidogenesis_Homo sapiens_hsa049130.25126496
128Non-small cell lung cancer_Homo sapiens_hsa052230.24348338
129Glutathione metabolism_Homo sapiens_hsa004800.23698359
130Glycerolipid metabolism_Homo sapiens_hsa005610.23260367
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23237765
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.22877126
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.22722196
134Antigen processing and presentation_Homo sapiens_hsa046120.22494201
135Collecting duct acid secretion_Homo sapiens_hsa049660.22201815
136Non-homologous end-joining_Homo sapiens_hsa034500.18374074
137Systemic lupus erythematosus_Homo sapiens_hsa053220.16979133
138Sphingolipid metabolism_Homo sapiens_hsa006000.16015903
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14738697
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13746582
141Synaptic vesicle cycle_Homo sapiens_hsa047210.13243023
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12337188
143Propanoate metabolism_Homo sapiens_hsa006400.04430550
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.00571405
145HIF-1 signaling pathway_Homo sapiens_hsa040660.00226047
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0337774
147Steroid biosynthesis_Homo sapiens_hsa00100-0.0313410
148Glioma_Homo sapiens_hsa05214-0.0226238
149Apoptosis_Homo sapiens_hsa04210-0.0091037

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