ESYT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.32159265
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.32159265
3positive regulation of gamma-delta T cell activation (GO:0046645)6.02616843
4antigen processing and presentation of endogenous antigen (GO:0019883)5.67180739
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.28656328
6COPI coating of Golgi vesicle (GO:0048205)5.01713044
7Golgi transport vesicle coating (GO:0048200)5.01713044
8regulation of gamma-delta T cell differentiation (GO:0045586)4.66961338
9hemidesmosome assembly (GO:0031581)4.41931259
10regulation of gamma-delta T cell activation (GO:0046643)4.36494255
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.28475750
12negative regulation of cell killing (GO:0031342)4.28475750
13positive thymic T cell selection (GO:0045059)4.22115256
14regulation of B cell receptor signaling pathway (GO:0050855)3.94718729
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.88856057
16cell-substrate junction assembly (GO:0007044)3.75249366
17negative T cell selection (GO:0043383)3.74344533
18negative thymic T cell selection (GO:0045060)3.74110284
19T cell migration (GO:0072678)3.70351970
20positive regulation of B cell differentiation (GO:0045579)3.68752093
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.63418220
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.63418220
23modulation by symbiont of host immune response (GO:0052553)3.63418220
24positive regulation by symbiont of host defense response (GO:0052509)3.63418220
25modulation by symbiont of host defense response (GO:0052031)3.63418220
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.63418220
27negative regulation of phagocytosis (GO:0050765)3.62259103
28interferon-gamma production (GO:0032609)3.62071261
29protein localization to endosome (GO:0036010)3.57897836
30response to interleukin-15 (GO:0070672)3.55692789
31JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.51993528
32antigen processing and presentation via MHC class Ib (GO:0002475)3.50417460
33leukocyte aggregation (GO:0070486)3.49855283
34thymic T cell selection (GO:0045061)3.48671780
35regulation of B cell differentiation (GO:0045577)3.44875906
36B cell receptor signaling pathway (GO:0050853)3.43259150
37regulation of interleukin-12 biosynthetic process (GO:0045075)3.41371641
38Arp2/3 complex-mediated actin nucleation (GO:0034314)3.39551530
39tolerance induction (GO:0002507)3.38025264
40mannose metabolic process (GO:0006013)3.37130853
41regulation of interferon-beta biosynthetic process (GO:0045357)3.36186341
42positive regulation of histone deacetylation (GO:0031065)3.29018238
43positive T cell selection (GO:0043368)3.27997717
44barbed-end actin filament capping (GO:0051016)3.16142696
45retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.15496037
46T cell selection (GO:0045058)3.12959964
47immunoglobulin mediated immune response (GO:0016064)3.12796105
48leukocyte cell-cell adhesion (GO:0007159)3.11312570
49focal adhesion assembly (GO:0048041)3.09470972
50cell-substrate adherens junction assembly (GO:0007045)3.09470972
51regulation of histone H3-K27 methylation (GO:0061085)3.06394594
52DNA unwinding involved in DNA replication (GO:0006268)3.06106651
53maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.05709799
54cellular extravasation (GO:0045123)3.03979999
55pentose-phosphate shunt (GO:0006098)3.02419724
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00887258
57regulation of type I interferon-mediated signaling pathway (GO:0060338)2.98634392
58neutrophil activation involved in immune response (GO:0002283)2.98195149
59nuclear pore complex assembly (GO:0051292)2.97625218
60protein retention in ER lumen (GO:0006621)2.97088935
61regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.96767655
62positive regulation of isotype switching (GO:0045830)2.94720780
63positive regulation of interferon-alpha production (GO:0032727)2.93239782
64regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92490302
65adherens junction assembly (GO:0034333)2.91907993
66hypotonic response (GO:0006971)2.91559563
67natural killer cell differentiation (GO:0001779)2.91231252
68regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.87784165
69negative regulation of interleukin-12 production (GO:0032695)2.87158038
70response to type I interferon (GO:0034340)2.85293832
71regulation of response to interferon-gamma (GO:0060330)2.85215868
72regulation of interferon-alpha production (GO:0032647)2.82249407
73respiratory burst (GO:0045730)2.81708149
74cellular response to interleukin-15 (GO:0071350)2.81225366
75cellular response to type I interferon (GO:0071357)2.78031201
76type I interferon signaling pathway (GO:0060337)2.78031201
77embryonic process involved in female pregnancy (GO:0060136)2.77977053
78positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.77636994
79pinocytosis (GO:0006907)2.77101502
80regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.76147620
81proline biosynthetic process (GO:0006561)2.75318107
82T cell costimulation (GO:0031295)2.75268093
83negative regulation of granulocyte differentiation (GO:0030853)2.73357717
84stress fiber assembly (GO:0043149)2.72892181
85skin morphogenesis (GO:0043589)2.71540688
86cell adhesion mediated by integrin (GO:0033627)2.71508362
87positive regulation of natural killer cell differentiation (GO:0032825)2.71427800
88response to muramyl dipeptide (GO:0032495)2.70461351
89basement membrane organization (GO:0071711)2.69442876
90lymphocyte costimulation (GO:0031294)2.69186426
91regulation of T cell tolerance induction (GO:0002664)2.68545819
92regulation of translational fidelity (GO:0006450)2.68177426
93antigen receptor-mediated signaling pathway (GO:0050851)2.67571626
94positive regulation of protein deacetylation (GO:0090312)2.67348904
95epithelial cell differentiation involved in prostate gland development (GO:0060742)2.64979782
96hyaluronan catabolic process (GO:0030214)2.64689962
97NIK/NF-kappaB signaling (GO:0038061)2.63547188
98negative regulation of cell size (GO:0045792)2.62327681
99regulation of natural killer cell mediated immunity (GO:0002715)2.62053619
100regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.62053619
101protein maturation by protein folding (GO:0022417)2.61834058
102natural killer cell activation (GO:0030101)2.61799108
103interferon-gamma-mediated signaling pathway (GO:0060333)2.61684653
104regulation of alpha-beta T cell proliferation (GO:0046640)2.61191441
105macrophage activation involved in immune response (GO:0002281)2.60956659
106T cell proliferation (GO:0042098)2.60208097
107regulation of extracellular matrix disassembly (GO:0010715)2.60196975
108T cell homeostasis (GO:0043029)2.59528587
109heterotypic cell-cell adhesion (GO:0034113)2.58727173
110negative regulation of erythrocyte differentiation (GO:0045647)2.58720513
111myeloid dendritic cell activation (GO:0001773)2.58700330
112response to laminar fluid shear stress (GO:0034616)2.58570794
113positive regulation of blood vessel endothelial cell migration (GO:0043536)2.58435870
114positive regulation of antigen processing and presentation (GO:0002579)2.58096288
115positive regulation of macrophage differentiation (GO:0045651)2.55583997
116response to protozoan (GO:0001562)2.54767195
117T cell receptor signaling pathway (GO:0050852)2.54316150
118cellular response to zinc ion (GO:0071294)2.54233418
119neutrophil activation (GO:0042119)2.54180370
120tyrosine phosphorylation of STAT protein (GO:0007260)2.54175072
121actin nucleation (GO:0045010)2.54120281
122positive regulation of lamellipodium assembly (GO:0010592)2.53702184
123positive regulation of interleukin-2 production (GO:0032743)2.53277071
124low-density lipoprotein particle clearance (GO:0034383)2.52927837
125regulation of defense response to virus by virus (GO:0050690)2.52794768
126myeloid cell activation involved in immune response (GO:0002275)2.51698002
127regulation of T cell receptor signaling pathway (GO:0050856)2.49896936
128positive regulation of immunoglobulin mediated immune response (GO:0002891)2.49765157
129positive regulation of B cell mediated immunity (GO:0002714)2.49765157
130NADPH regeneration (GO:0006740)2.49763687
131glucose catabolic process (GO:0006007)2.49178872
132activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.48802815
133membrane raft organization (GO:0031579)2.48226382
134positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.48150581
135vesicle coating (GO:0006901)2.47100174
136lymphocyte homeostasis (GO:0002260)2.46952324
137cortical actin cytoskeleton organization (GO:0030866)2.46821052
138apoptotic process involved in morphogenesis (GO:0060561)2.46129081
139mast cell activation (GO:0045576)2.45989631
140regulation of early endosome to late endosome transport (GO:2000641)2.43752677
141membrane protein ectodomain proteolysis (GO:0006509)2.42520450
1423-UTR-mediated mRNA stabilization (GO:0070935)2.41328843
143positive regulation of nuclease activity (GO:0032075)2.41128551
144platelet aggregation (GO:0070527)2.39139532
145endoplasmic reticulum unfolded protein response (GO:0030968)2.36808874
146positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.34277196
147endodermal cell differentiation (GO:0035987)2.34233158
148cellular response to interleukin-4 (GO:0071353)2.33985925
149positive regulation of endothelial cell apoptotic process (GO:2000353)2.33806464
150positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.33577962
151negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.31766293
152mammary gland epithelial cell proliferation (GO:0033598)2.30610413
153peptidyl-proline hydroxylation (GO:0019511)2.29585054
154activation of Rac GTPase activity (GO:0032863)2.29410810
155negative regulation of stress fiber assembly (GO:0051497)2.28992043
156cellular response to epidermal growth factor stimulus (GO:0071364)2.28649651
157negative regulation of viral release from host cell (GO:1902187)2.27041729
158modulation by symbiont of host cellular process (GO:0044068)2.26945184
159tricarboxylic acid metabolic process (GO:0072350)2.26881568
160spliceosomal tri-snRNP complex assembly (GO:0000244)2.24999583
161definitive hemopoiesis (GO:0060216)2.24558869
162nuclear pore organization (GO:0006999)2.24345833
163ER-nucleus signaling pathway (GO:0006984)2.23552460
164negative regulation of fatty acid transport (GO:2000192)2.19261592
165protein hydroxylation (GO:0018126)2.18886510
166regulation of nuclease activity (GO:0032069)2.18801183
167insulin-like growth factor receptor signaling pathway (GO:0048009)2.18514328
168mitotic chromosome condensation (GO:0007076)2.17235765
169cellular response to unfolded protein (GO:0034620)2.17146560
170maternal placenta development (GO:0001893)2.16801134
171glucose 6-phosphate metabolic process (GO:0051156)2.16744096
172positive regulation of keratinocyte differentiation (GO:0045618)2.16205673
173COPII vesicle coating (GO:0048208)2.16081334
174protein export from nucleus (GO:0006611)2.16003907
175regulation of glucose import in response to insulin stimulus (GO:2001273)2.15037205

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.21982885
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.89384874
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.86753480
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.46990179
5* E2F7_22180533_ChIP-Seq_HELA_Human3.37746862
6MYC_22102868_ChIP-Seq_BL_Human3.27062583
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.23952715
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.13754472
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12680439
10VDR_21846776_ChIP-Seq_THP-1_Human2.88594176
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.81098387
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.79464511
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.66390420
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62792271
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57138133
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.50410420
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48116258
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47255189
19MYB_26560356_Chip-Seq_TH2_Human2.39046260
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38903910
21* MAF_26560356_Chip-Seq_TH1_Human2.36857072
22RUNX_20019798_ChIP-Seq_JUKART_Human2.23951127
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23710834
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.18394700
25* UTX_26944678_Chip-Seq_JUKART_Human2.12944023
26* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12866946
27VDR_24763502_ChIP-Seq_THP-1_Human2.12007423
28* MYB_26560356_Chip-Seq_TH1_Human2.09066264
29TCF7_22412390_ChIP-Seq_EML_Mouse2.06172584
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05839796
31SCL_19346495_ChIP-Seq_HPC-7_Human2.03921784
32* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.03561846
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.98362097
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.98348851
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98128144
36SPI1_23547873_ChIP-Seq_NB4_Human1.97766895
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94587413
38ZNF263_19887448_ChIP-Seq_K562_Human1.92193285
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92167874
40* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83710370
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.78614651
42SPI1_23127762_ChIP-Seq_K562_Human1.77967391
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75272432
44KDM2B_26808549_Chip-Seq_DND41_Human1.73847722
45* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72167872
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64665048
47* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59291722
48MAF_26560356_Chip-Seq_TH2_Human1.55271465
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54748482
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53335853
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49255675
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48259093
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45867809
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45670446
55GATA3_27048872_Chip-Seq_THYMUS_Human1.44656884
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43715097
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42579676
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40737751
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39846835
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36303391
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33717830
62* PU_27001747_Chip-Seq_BMDM_Mouse1.31232472
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31029732
64GATA1_22025678_ChIP-Seq_K562_Human1.30661413
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28254025
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28136792
67* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25139547
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25098012
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.23708267
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23599877
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22862767
72TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22770724
73* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20060287
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18632655
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18481508
76ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17366942
77* ATF3_27146783_Chip-Seq_COLON_Human1.16884354
78* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16267153
79* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16184613
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16053214
81CIITA_25753668_ChIP-Seq_RAJI_Human1.15756582
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15606196
83CLOCK_20551151_ChIP-Seq_293T_Human1.15421929
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14538577
85* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14030759
86* NCOR1_26117541_ChIP-Seq_K562_Human1.11894418
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11825851
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10489561
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10349003
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09578664
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09552864
92* TFEB_21752829_ChIP-Seq_HELA_Human1.08845915
93MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08228610
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07971250
95KDM2B_26808549_Chip-Seq_K562_Human1.06931624
96NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06725986
97* LXR_22292898_ChIP-Seq_THP-1_Human1.05749390
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05332884
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04563688
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04563688
101* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04103714
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01941528
103* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01875599
104TP63_17297297_ChIP-ChIP_HaCaT_Human1.01497009
105TET1_21451524_ChIP-Seq_MESCs_Mouse0.99582413
106* SA1_27219007_Chip-Seq_ERYTHROID_Human0.99376379
107* KDM2B_26808549_Chip-Seq_JURKAT_Human0.97719481
108UBF1/2_26484160_Chip-Seq_HMECs_Human0.97621921
109HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97558133
110ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95751210
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.94850677
112ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94332735
113GATA3_26560356_Chip-Seq_TH2_Human0.93657046
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93429372
115GATA1_19941826_ChIP-Seq_K562_Human0.92095230
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92056614
117* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91687779
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89585686
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.88653613
120RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88108341
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.87715863
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87188478
123* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86874606
124VDR_24787735_ChIP-Seq_THP-1_Human0.85183212
125STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84807106
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84769218
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84193485
128* RACK7_27058665_Chip-Seq_MCF-7_Human0.83893785
129* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83866108
130FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83476477
131CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81863676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.35222934
2MP0003436_decreased_susceptibility_to2.87651849
3MP0003303_peritoneal_inflammation2.84937711
4MP0000685_abnormal_immune_system2.79655091
5MP0003300_gastrointestinal_ulcer2.78594507
6MP0001800_abnormal_humoral_immune2.64964872
7MP0005387_immune_system_phenotype2.64685323
8MP0001790_abnormal_immune_system2.64685323
9MP0005671_abnormal_response_to2.63160897
10MP0005000_abnormal_immune_tolerance2.54099728
11MP0003763_abnormal_thymus_physiology2.46022445
12MP0002452_abnormal_antigen_presenting2.39993259
13MP0005451_abnormal_body_composition2.37908168
14MP0002723_abnormal_immune_serum2.27100977
15MP0002166_altered_tumor_susceptibility2.26330460
16MP0002420_abnormal_adaptive_immunity2.26251937
17MP0001819_abnormal_immune_cell2.23935183
18MP0009785_altered_susceptibility_to2.21108470
19MP0005025_abnormal_response_to2.20340694
20MP0002396_abnormal_hematopoietic_system2.16998311
21MP0006082_CNS_inflammation2.16647198
22MP0002419_abnormal_innate_immunity2.16622015
23MP0004272_abnormal_basement_membrane2.16006148
24MP0002398_abnormal_bone_marrow2.09677262
25MP0008260_abnormal_autophagy2.08699679
26MP0005464_abnormal_platelet_physiology1.98431643
27MP0005058_abnormal_lysosome_morphology1.97356772
28MP0002405_respiratory_system_inflammati1.95763438
29MP0010352_gastrointestinal_tract_polyps1.90265400
30MP0002006_tumorigenesis1.89323882
31MP0000716_abnormal_immune_system1.87962290
32MP0003724_increased_susceptibility_to1.86723864
33MP0001849_ear_inflammation1.86206422
34MP0009333_abnormal_splenocyte_physiolog1.84503097
35MP0004947_skin_inflammation1.78382456
36MP0009278_abnormal_bone_marrow1.78004113
37MP0004808_abnormal_hematopoietic_stem1.76740119
38MP0003566_abnormal_cell_adhesion1.76439051
39MP0000689_abnormal_spleen_morphology1.75430059
40MP0002148_abnormal_hypersensitivity_rea1.75296546
41MP0002722_abnormal_immune_system1.72404933
42MP0003172_abnormal_lysosome_physiology1.71529744
43MP0010155_abnormal_intestine_physiology1.69239372
44MP0010307_abnormal_tumor_latency1.66081857
45MP0008438_abnormal_cutaneous_collagen1.62704985
46MP0003448_altered_tumor_morphology1.61196211
47MP0002429_abnormal_blood_cell1.60250896
48MP0001533_abnormal_skeleton_physiology1.59625793
49MP0000858_altered_metastatic_potential1.59339019
50MP0002060_abnormal_skin_morphology1.59289206
51MP0005397_hematopoietic_system_phenotyp1.57786044
52MP0001545_abnormal_hematopoietic_system1.57786044
53MP0001845_abnormal_inflammatory_respons1.57453367
54MP0003705_abnormal_hypodermis_morpholog1.54830683
55MP0000703_abnormal_thymus_morphology1.53148606
56MP0001873_stomach_inflammation1.48017233
57MP0004510_myositis1.46545704
58MP0004233_abnormal_muscle_weight1.44680864
59MP0002933_joint_inflammation1.43394702
60MP0005076_abnormal_cell_differentiation1.42586321
61MP0000465_gastrointestinal_hemorrhage1.38607099
62MP0002796_impaired_skin_barrier1.37335918
63MP0001853_heart_inflammation1.34770672
64MP0003866_abnormal_defecation1.32345806
65MP0010234_abnormal_vibrissa_follicle1.31483270
66MP0005409_darkened_coat_color1.29714639
67MP0003191_abnormal_cellular_cholesterol1.27176846
68MP0001661_extended_life_span1.24840161
69MP0002877_abnormal_melanocyte_morpholog1.24232783
70MP0000490_abnormal_crypts_of1.24068355
71MP0004185_abnormal_adipocyte_glucose1.20942331
72MP0005310_abnormal_salivary_gland1.17145224
73MP0005257_abnormal_intraocular_pressure1.15643060
74MP0005023_abnormal_wound_healing1.14551023
75MP0005670_abnormal_white_adipose1.14087379
76MP0008469_abnormal_protein_level1.13426021
77MP0002998_abnormal_bone_remodeling1.09841623
78MP0003828_pulmonary_edema1.07591030
79MP0005501_abnormal_skin_physiology1.07296089
80MP0005621_abnormal_cell_physiology1.06371957
81MP0003091_abnormal_cell_migration1.06041206
82MP0001216_abnormal_epidermal_layer1.04831485
83MP0001348_abnormal_lacrimal_gland1.04826890
84MP0000343_altered_response_to1.04086290
85MP0004264_abnormal_extraembryonic_tissu1.03225368
86MP0000569_abnormal_digit_pigmentation1.02908150
87MP0006054_spinal_hemorrhage1.00297319
88MP0003279_aneurysm1.00044189
89MP0009840_abnormal_foam_cell0.99563215
90MP0003045_fibrosis0.98774937
91MP0001730_embryonic_growth_arrest0.96917148
92MP0002019_abnormal_tumor_incidence0.95118999
93MP0004381_abnormal_hair_follicle0.94420815
94MP0001851_eye_inflammation0.94274591
95MP0004858_abnormal_nervous_system0.93372302
96MP0009931_abnormal_skin_appearance0.93213048
97MP0003950_abnormal_plasma_membrane0.93127693
98MP0001958_emphysema0.92994943
99MP0005623_abnormal_meninges_morphology0.89810523
100MP0003111_abnormal_nucleus_morphology0.89510814
101MP0010368_abnormal_lymphatic_system0.88858803
102MP0004130_abnormal_muscle_cell0.87520461
103MP0005666_abnormal_adipose_tissue0.86653338
104MP0002086_abnormal_extraembryonic_tissu0.86057019
105MP0000678_abnormal_parathyroid_gland0.86011131
106MP0002009_preneoplasia0.85980981
107MP0000350_abnormal_cell_proliferation0.84103257
108MP0005174_abnormal_tail_pigmentation0.83549044
109MP0000733_abnormal_muscle_development0.81084368
110MP0001243_abnormal_dermal_layer0.80388278
111MP0009115_abnormal_fat_cell0.80214782
112MP0005390_skeleton_phenotype0.78426242
113MP0008961_abnormal_basal_metabolism0.77872701
114MP0005375_adipose_tissue_phenotype0.77419169
115MP0002080_prenatal_lethality0.74996331
116MP0000249_abnormal_blood_vessel0.74866147
117MP0003656_abnormal_erythrocyte_physiolo0.74767547
118MP0009384_cardiac_valve_regurgitation0.74676910
119MP0001881_abnormal_mammary_gland0.74529937
120MP0003959_abnormal_lean_body0.74050063
121MP0003183_abnormal_peptide_metabolism0.73752634
122MP0003795_abnormal_bone_structure0.72402404
123MP0009763_increased_sensitivity_to0.71752325
124MP0002970_abnormal_white_adipose0.68348466
125MP0000767_abnormal_smooth_muscle0.62413279
126MP0000371_diluted_coat_color0.62403925
127MP0000609_abnormal_liver_physiology0.61362157
128MP0002136_abnormal_kidney_physiology0.60994405
129MP0000003_abnormal_adipose_tissue0.60093115
130MP0005275_abnormal_skin_tensile0.59923376
131MP0000604_amyloidosis0.59642080
132MP0001915_intracranial_hemorrhage0.58684468
133MP0005166_decreased_susceptibility_to0.58417876
134MP0003453_abnormal_keratinocyte_physiol0.57846988

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.37925280
2Recurrent abscess formation (HP:0002722)4.20785176
3Premature rupture of membranes (HP:0001788)3.96991126
4Protrusio acetabuli (HP:0003179)3.78026192
5Recurrent viral infections (HP:0004429)3.64437641
6Recurrent fungal infections (HP:0002841)3.61727312
7Elevated erythrocyte sedimentation rate (HP:0003565)3.54795973
8Myositis (HP:0100614)3.53558390
9Recurrent bacterial skin infections (HP:0005406)3.50135309
10Chronic otitis media (HP:0000389)3.48206047
11Cellulitis (HP:0100658)3.47817200
12T lymphocytopenia (HP:0005403)3.46631006
13Recurrent bronchitis (HP:0002837)3.46336394
14Nasal polyposis (HP:0100582)3.30947126
15Abnormality of T cell number (HP:0011839)3.27889389
16IgM deficiency (HP:0002850)3.26565498
17Vertebral compression fractures (HP:0002953)3.14490172
18Autoimmune thrombocytopenia (HP:0001973)3.09576394
19Abnormality of the nasal mucosa (HP:0000433)3.07052911
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.00768728
21Abnormality of T cells (HP:0002843)2.92107618
22Abnormality of macrophages (HP:0004311)2.89553175
23Vacuolated lymphocytes (HP:0001922)2.88252663
24Spontaneous hematomas (HP:0007420)2.88153540
25Inflammation of the large intestine (HP:0002037)2.88070401
26Gastrointestinal inflammation (HP:0004386)2.86985505
27Atrophic scars (HP:0001075)2.83478423
28Cerebral aneurysm (HP:0004944)2.83285411
29Meningitis (HP:0001287)2.79508128
30Increased cerebral lipofuscin (HP:0011813)2.79322962
31Increased density of long bones (HP:0006392)2.76949087
32Chronic mucocutaneous candidiasis (HP:0002728)2.74701709
33Recurrent cutaneous fungal infections (HP:0011370)2.74701709
34Recurrent gram-negative bacterial infections (HP:0005420)2.72038023
35Orchitis (HP:0100796)2.70064854
36Pustule (HP:0200039)2.69970414
37Abnormality of oral frenula (HP:0000190)2.68986068
38Increased connective tissue (HP:0009025)2.67314412
39Mediastinal lymphadenopathy (HP:0100721)2.65831015
40Broad face (HP:0000283)2.65561820
41Interstitial pulmonary disease (HP:0006530)2.63307854
42Vasculitis (HP:0002633)2.61390167
43Recurrent skin infections (HP:0001581)2.61044151
44Dysostosis multiplex (HP:0000943)2.60742057
45Colitis (HP:0002583)2.60405966
46Papilloma (HP:0012740)2.53776383
47Verrucae (HP:0200043)2.53776383
48Prolonged bleeding time (HP:0003010)2.53004693
49Agammaglobulinemia (HP:0004432)2.52160488
50Centrally nucleated skeletal muscle fibers (HP:0003687)2.49747539
51Abnormality of the fingertips (HP:0001211)2.48200626
52Thrombocytosis (HP:0001894)2.48180197
53Abnormality of T cell physiology (HP:0011840)2.47369681
54Fragile skin (HP:0001030)2.46475387
55Hyperacusis (HP:0010780)2.44464657
56Panhypogammaglobulinemia (HP:0003139)2.43645313
57Ankyloglossia (HP:0010296)2.43463546
58Hematochezia (HP:0002573)2.42225329
59Increased variability in muscle fiber diameter (HP:0003557)2.41923449
60Obstructive lung disease (HP:0006536)2.41849174
61Chronic obstructive pulmonary disease (HP:0006510)2.41849174
62Abnormality of skeletal muscle fiber size (HP:0012084)2.41361730
63Distal lower limb amyotrophy (HP:0008944)2.40903945
64Osteomyelitis (HP:0002754)2.40790993
65Increased IgE level (HP:0003212)2.39870052
66Spinal rigidity (HP:0003306)2.39066680
67Mucopolysacchariduria (HP:0008155)2.37573367
68Urinary glycosaminoglycan excretion (HP:0003541)2.37573367
69Arterial thrombosis (HP:0004420)2.37006617
70Retrobulbar optic neuritis (HP:0100654)2.36673096
71Optic neuritis (HP:0100653)2.36673096
72Aortic aneurysm (HP:0004942)2.36590184
73Abnormal platelet volume (HP:0011876)2.36189217
74Periodontitis (HP:0000704)2.35468099
75Gingivitis (HP:0000230)2.33416893
76Emphysema (HP:0002097)2.33138304
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.29812743
78Osteolytic defects of the hand bones (HP:0009699)2.29812743
79Short nail (HP:0001799)2.27552162
80Lymphopenia (HP:0001888)2.24972850
81Myocardial infarction (HP:0001658)2.22236624
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21255425
83Abnormality of polysaccharide metabolism (HP:0011012)2.21255425
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21255425
85Wormian bones (HP:0002645)2.20851079
86Abnormality of cells of the lymphoid lineage (HP:0012140)2.19497842
87Stomatitis (HP:0010280)2.18812353
88Disproportionate tall stature (HP:0001519)2.18756991
89Increased neuronal autofluorescent lipopigment (HP:0002074)2.16526512
90Spinal cord lesions (HP:0100561)2.15433108
91Syringomyelia (HP:0003396)2.15433108
92Ankle contracture (HP:0006466)2.13767188
93Petechiae (HP:0000967)2.12434356
94Leukocytosis (HP:0001974)2.12202084
95Pulmonary infiltrates (HP:0002113)2.11539423
96Milia (HP:0001056)2.09708154
97Hemoptysis (HP:0002105)2.07487952
98Epistaxis (HP:0000421)2.06730791
99Impaired platelet aggregation (HP:0003540)2.06344446
100Abnormal platelet function (HP:0011869)2.06344446
101Back pain (HP:0003418)2.04489130
102Biconcave vertebral bodies (HP:0004586)2.04075335
103Achilles tendon contracture (HP:0001771)2.03952703
104Gastrointestinal stroma tumor (HP:0100723)2.01865996
105Onycholysis (HP:0001806)2.01482946
106Distal lower limb muscle weakness (HP:0009053)2.01246093
107IgA deficiency (HP:0002720)2.00937358
108Frequent falls (HP:0002359)2.00601913
109Blue sclerae (HP:0000592)1.99734947
110Dilatation of the ascending aorta (HP:0005111)1.98699611
111Chest pain (HP:0100749)1.98214600
112Arterial tortuosity (HP:0005116)1.96478885
113Increased mean platelet volume (HP:0011877)1.96387288
114Skin ulcer (HP:0200042)1.94736020
115Loss of speech (HP:0002371)1.94371972
116Selective tooth agenesis (HP:0001592)1.94235719
117Restrictive lung disease (HP:0002091)1.92864460
118Chronic sinusitis (HP:0011109)1.91607442
119Combined immunodeficiency (HP:0005387)1.91279916
120Flat acetabular roof (HP:0003180)1.91218212
121Aneurysm (HP:0002617)1.91062133
122Ulnar bowing (HP:0003031)1.90934255
123Thyroiditis (HP:0100646)1.90622613
124Vascular tortuosity (HP:0004948)1.90471352
125Persistence of primary teeth (HP:0006335)1.87014772
126Abnormality of the Achilles tendon (HP:0005109)1.86992316
127Thin bony cortex (HP:0002753)1.86636051
128Spondylolisthesis (HP:0003302)1.85884126
129Cervical subluxation (HP:0003308)1.85089186
130Cholecystitis (HP:0001082)1.85070518
131Abnormal gallbladder physiology (HP:0012438)1.85070518
132Mitral valve prolapse (HP:0001634)1.84398298
133Eosinophilia (HP:0001880)1.82592908
134Gingival bleeding (HP:0000225)1.82146661
135Aortic dissection (HP:0002647)1.80060205
136Mitral regurgitation (HP:0001653)1.79792788
137Upper limb amyotrophy (HP:0009129)1.79684913
138Distal upper limb amyotrophy (HP:0007149)1.79684913
139Thoracic kyphosis (HP:0002942)1.79321864
140Abnormality of glycolipid metabolism (HP:0010969)1.79088560
141Abnormality of liposaccharide metabolism (HP:0010968)1.79088560
142Abnormality of glycosphingolipid metabolism (HP:0004343)1.79088560
143Polycythemia (HP:0001901)1.78175098
144Natal tooth (HP:0000695)1.78083142
145Abnormality of the distal phalanges of the toes (HP:0010182)1.76180362
146Reticulocytosis (HP:0001923)1.73467281
147Premature skin wrinkling (HP:0100678)1.73298367
148Hypertriglyceridemia (HP:0002155)1.73118497
149Abnormality of the thoracic spine (HP:0100711)1.72239346
150Menorrhagia (HP:0000132)1.72110111
151Elbow flexion contracture (HP:0002987)1.70849113
152Trismus (HP:0000211)1.68657729
153Bladder diverticulum (HP:0000015)1.67944290
154Advanced eruption of teeth (HP:0006288)1.67193880
155Shallow orbits (HP:0000586)1.67165040
156Dislocated radial head (HP:0003083)1.67122028
157Polygenic inheritance (HP:0010982)1.66753053
158Orthostatic hypotension (HP:0001278)1.65955633
159Hemorrhage of the eye (HP:0011885)1.65751455
160Joint laxity (HP:0001388)1.65616792
161Deep venous thrombosis (HP:0002625)1.63948852
162Long palpebral fissure (HP:0000637)1.63872230
163Nail dystrophy (HP:0008404)1.62838466
164Difficulty climbing stairs (HP:0003551)1.62623594
165J-shaped sella turcica (HP:0002680)1.62262541
166Fatigue (HP:0012378)1.62252770
167Genu recurvatum (HP:0002816)1.62075811
168Nonimmune hydrops fetalis (HP:0001790)1.60239439
169Entropion (HP:0000621)1.59725245
170Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.59569672
171Gastrointestinal dysmotility (HP:0002579)1.58347721
172Abnormality of the tricuspid valve (HP:0001702)1.57832556
173Thick nail (HP:0001805)1.56555416
174Glucose intolerance (HP:0000833)1.56157593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.34413641
2TRIB33.32310754
3SMG13.29369727
4EEF2K2.99850482
5PRPF4B2.93975683
6JAK32.71400697
7ERN12.54336030
8PKN22.54159681
9MAP3K102.53419780
10TYK22.36236645
11STK102.18051458
12ICK2.17443780
13ZAP702.13894058
14TXK2.04634173
15TTN1.97974899
16JAK11.91890115
17TBK11.87229012
18KIT1.82493729
19ITK1.76156058
20BLK1.75766172
21FGFR41.69917018
22LRRK21.67778217
23GRK61.64419922
24BTK1.62260938
25FGFR31.54707792
26MAP3K141.49111263
27TGFBR21.46653584
28IKBKE1.46640024
29EPHB11.39583062
30MAP2K31.38779670
31KSR21.37655942
32SYK1.37312294
33CDK121.35688231
34CSF1R1.33840201
35HCK1.33758760
36CSK1.32185954
37CAMK1D1.31231306
38LCK1.27292840
39TESK11.26344832
40IRAK41.24302060
41SIK11.24104647
42RPS6KA41.20184381
43TEC1.20101852
44EPHA21.16831715
45NME21.16771424
46TAOK31.15268378
47PTK61.12925449
48SCYL21.12122700
49FLT31.08717148
50RIPK11.08166488
51MAP3K11.05456634
52EPHA31.04825041
53PIM11.03909535
54RIPK41.02834176
55IKBKB1.01692604
56JAK21.01558896
57FES1.00945651
58SIK21.00268712
59TAOK21.00233835
60MST1R0.98615260
61PTK20.98586796
62PRKD20.94571059
63MARK30.93103206
64ARAF0.90405081
65TRPM70.88922260
66KDR0.87311642
67IRAK30.86807234
68PRKCH0.86792041
69NEK20.86263875
70CAMK1G0.82697297
71NLK0.82435877
72CDK40.81776616
73CDK60.80362203
74NTRK10.78828545
75MAP3K130.78651372
76MAP2K20.75618325
77LYN0.75466204
78NEK90.75121474
79HIPK20.74223055
80CHUK0.72950602
81STK380.72402894
82PASK0.71813520
83PIM20.70699387
84CDC42BPA0.70125774
85MAP3K60.69895277
86CLK10.69176986
87ALK0.66482173
88MAP3K30.66168804
89MOS0.63403812
90MAPKAPK30.62024112
91PDGFRA0.61615970
92MAP3K80.61159542
93PDGFRB0.60506664
94TESK20.60315809
95LMTK20.60247280
96RPS6KB20.60195420
97MARK20.59224582
98PDPK10.57760962
99CDK90.57056880
100CDK70.56616295
101MAP3K20.55496384
102TGFBR10.55223698
103BMX0.54401090
104STK40.54278619
105PAK40.53944960
106TNK20.52378042
107RAF10.51819828
108DMPK0.50812302
109MTOR0.50532355
110EIF2AK10.49386314
111MELK0.46789838
112RET0.46321965
113SIK30.46173627
114MAP3K110.45028457
115RPS6KA60.45022609
116ILK0.44899094
117PRKCQ0.44023261
118TAOK10.42902525
119MAPKAPK20.42754050
120PRKG20.41856910
121PDK10.40924995
122MAP3K70.40172499
123MAP3K90.40038909
124MET0.39878152
125EGFR0.39246609
126RPS6KL10.38412770
127RPS6KC10.38412770
128RPS6KA20.38284757
129ABL10.37666765
130PAK20.37281863
131MAPK110.35497494

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.87103308
2Leishmaniasis_Homo sapiens_hsa051402.54093317
3B cell receptor signaling pathway_Homo sapiens_hsa046622.38479944
4Osteoclast differentiation_Homo sapiens_hsa043802.25727258
5Antigen processing and presentation_Homo sapiens_hsa046122.21599025
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.15895842
7Measles_Homo sapiens_hsa051622.14203666
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05514993
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02792667
10T cell receptor signaling pathway_Homo sapiens_hsa046601.86714354
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78515712
12Pentose phosphate pathway_Homo sapiens_hsa000301.76630947
13Hematopoietic cell lineage_Homo sapiens_hsa046401.71672566
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.70376108
15Toxoplasmosis_Homo sapiens_hsa051451.69987641
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69111608
17Chronic myeloid leukemia_Homo sapiens_hsa052201.65565262
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.61292392
19Graft-versus-host disease_Homo sapiens_hsa053321.57959959
20Acute myeloid leukemia_Homo sapiens_hsa052211.55767326
21Viral myocarditis_Homo sapiens_hsa054161.55395258
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.50978652
23Apoptosis_Homo sapiens_hsa042101.49548128
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49398868
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.48809072
26Tuberculosis_Homo sapiens_hsa051521.44922625
27Staphylococcus aureus infection_Homo sapiens_hsa051501.44402968
28Malaria_Homo sapiens_hsa051441.43335088
29ECM-receptor interaction_Homo sapiens_hsa045121.42410599
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42382060
31Shigellosis_Homo sapiens_hsa051311.42380254
32Bladder cancer_Homo sapiens_hsa052191.41491111
33Lysosome_Homo sapiens_hsa041421.41474359
34Legionellosis_Homo sapiens_hsa051341.40663181
35Hepatitis B_Homo sapiens_hsa051611.38234091
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36014376
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34612816
38Pertussis_Homo sapiens_hsa051331.33689718
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33264335
40Other glycan degradation_Homo sapiens_hsa005111.32152827
41Pancreatic cancer_Homo sapiens_hsa052121.31756830
42Influenza A_Homo sapiens_hsa051641.31229515
43TNF signaling pathway_Homo sapiens_hsa046681.30254931
44Herpes simplex infection_Homo sapiens_hsa051681.29639661
45Allograft rejection_Homo sapiens_hsa053301.28386148
46Chemokine signaling pathway_Homo sapiens_hsa040621.26220468
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26056381
48Platelet activation_Homo sapiens_hsa046111.24858251
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21085353
50Galactose metabolism_Homo sapiens_hsa000521.12326259
51N-Glycan biosynthesis_Homo sapiens_hsa005101.10644483
52Biosynthesis of amino acids_Homo sapiens_hsa012301.07583581
53Small cell lung cancer_Homo sapiens_hsa052221.06867264
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.05471052
55Salmonella infection_Homo sapiens_hsa051321.04050307
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03779906
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00353547
58HTLV-I infection_Homo sapiens_hsa051660.99469073
59Viral carcinogenesis_Homo sapiens_hsa052030.96776568
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95406030
61Non-small cell lung cancer_Homo sapiens_hsa052230.94482505
62Prolactin signaling pathway_Homo sapiens_hsa049170.93685468
63Prion diseases_Homo sapiens_hsa050200.93531850
64VEGF signaling pathway_Homo sapiens_hsa043700.93525075
65Fructose and mannose metabolism_Homo sapiens_hsa000510.93489921
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93025066
67Insulin resistance_Homo sapiens_hsa049310.91712726
68Hepatitis C_Homo sapiens_hsa051600.89416173
69Inositol phosphate metabolism_Homo sapiens_hsa005620.89259590
70Asthma_Homo sapiens_hsa053100.88225391
71Epstein-Barr virus infection_Homo sapiens_hsa051690.86584021
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84809038
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81899117
74Carbon metabolism_Homo sapiens_hsa012000.81638513
75Focal adhesion_Homo sapiens_hsa045100.81481980
76mTOR signaling pathway_Homo sapiens_hsa041500.81324030
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.80784693
78Colorectal cancer_Homo sapiens_hsa052100.80084364
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79846822
80Proteoglycans in cancer_Homo sapiens_hsa052050.79140515
81ErbB signaling pathway_Homo sapiens_hsa040120.78713176
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78334735
83Autoimmune thyroid disease_Homo sapiens_hsa053200.76040456
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75738559
85Amoebiasis_Homo sapiens_hsa051460.75408752
86HIF-1 signaling pathway_Homo sapiens_hsa040660.74465786
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73236039
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72188197
89Phagosome_Homo sapiens_hsa041450.70015557
90Lysine degradation_Homo sapiens_hsa003100.69403062
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65956641
92DNA replication_Homo sapiens_hsa030300.65382148
93MicroRNAs in cancer_Homo sapiens_hsa052060.64091874
94Endocytosis_Homo sapiens_hsa041440.63287796
95Rheumatoid arthritis_Homo sapiens_hsa053230.62738865
96AMPK signaling pathway_Homo sapiens_hsa041520.60849939
97Notch signaling pathway_Homo sapiens_hsa043300.60673376
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60353251
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58932949
100p53 signaling pathway_Homo sapiens_hsa041150.58644820
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.58584099
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57984143
103FoxO signaling pathway_Homo sapiens_hsa040680.57027227
104Caffeine metabolism_Homo sapiens_hsa002320.56075815
105Type I diabetes mellitus_Homo sapiens_hsa049400.55669917
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.55660379
107Prostate cancer_Homo sapiens_hsa052150.55419584
108Renal cell carcinoma_Homo sapiens_hsa052110.54908337
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54541693
110Choline metabolism in cancer_Homo sapiens_hsa052310.53795898
111Type II diabetes mellitus_Homo sapiens_hsa049300.53739178
112Cell cycle_Homo sapiens_hsa041100.52901216
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51432203
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50849020
115Endometrial cancer_Homo sapiens_hsa052130.50172320
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49862330
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.49301859
118Thyroid cancer_Homo sapiens_hsa052160.47556306
119Insulin signaling pathway_Homo sapiens_hsa049100.47425015
120Glioma_Homo sapiens_hsa052140.46771113
121Adherens junction_Homo sapiens_hsa045200.46332254
122Renin-angiotensin system_Homo sapiens_hsa046140.42697516
123Base excision repair_Homo sapiens_hsa034100.40792480
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40544391
125Pathways in cancer_Homo sapiens_hsa052000.39260562

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