ETAA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.39006574
2mitotic metaphase plate congression (GO:0007080)5.32506961
3DNA unwinding involved in DNA replication (GO:0006268)5.24365376
4protein localization to chromosome, centromeric region (GO:0071459)4.95254534
5mitotic chromosome condensation (GO:0007076)4.78270711
6nuclear pore complex assembly (GO:0051292)4.78172613
7kinetochore organization (GO:0051383)4.76592496
8nuclear pore organization (GO:0006999)4.76128640
9metaphase plate congression (GO:0051310)4.68080366
10regulation of centriole replication (GO:0046599)4.53930327
11DNA replication initiation (GO:0006270)4.52288570
12mitotic sister chromatid segregation (GO:0000070)4.51889299
13DNA replication checkpoint (GO:0000076)4.49647495
14DNA strand elongation involved in DNA replication (GO:0006271)4.38876834
15chromatin remodeling at centromere (GO:0031055)4.33940685
16sister chromatid segregation (GO:0000819)4.30113641
17CENP-A containing nucleosome assembly (GO:0034080)4.29521657
18meiotic chromosome segregation (GO:0045132)4.23511192
19DNA strand elongation (GO:0022616)4.20900338
20kinetochore assembly (GO:0051382)4.19949931
21mitotic nuclear envelope disassembly (GO:0007077)4.19029834
22attachment of spindle microtubules to kinetochore (GO:0008608)4.18153156
23regulation of spindle organization (GO:0090224)4.09195684
24establishment of chromosome localization (GO:0051303)4.08967169
25mitotic G2/M transition checkpoint (GO:0044818)4.07363848
26DNA replication-independent nucleosome assembly (GO:0006336)4.03008860
27DNA replication-independent nucleosome organization (GO:0034724)4.03008860
28DNA replication-dependent nucleosome organization (GO:0034723)4.00449839
29DNA replication-dependent nucleosome assembly (GO:0006335)4.00449839
30mitotic sister chromatid cohesion (GO:0007064)4.00347785
31telomere maintenance via semi-conservative replication (GO:0032201)3.97066121
32nuclear envelope disassembly (GO:0051081)3.92369285
33membrane disassembly (GO:0030397)3.92369285
34DNA double-strand break processing (GO:0000729)3.91279264
35mitotic recombination (GO:0006312)3.88072063
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.83810095
37non-recombinational repair (GO:0000726)3.79923948
38double-strand break repair via nonhomologous end joining (GO:0006303)3.79923948
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.79884111
40telomere maintenance via recombination (GO:0000722)3.76908022
41histone exchange (GO:0043486)3.71596372
42DNA duplex unwinding (GO:0032508)3.68124981
43positive regulation of chromosome segregation (GO:0051984)3.67348305
44DNA geometric change (GO:0032392)3.66564172
45protein localization to chromosome (GO:0034502)3.64650246
46negative regulation of DNA-dependent DNA replication (GO:2000104)3.60438009
47mitotic G2 DNA damage checkpoint (GO:0007095)3.60350752
48nucleobase biosynthetic process (GO:0046112)3.59724767
49pore complex assembly (GO:0046931)3.59433797
50regulation of mitotic spindle organization (GO:0060236)3.57821657
51spindle checkpoint (GO:0031577)3.55103204
52IMP biosynthetic process (GO:0006188)3.53703373
53regulation of double-strand break repair via homologous recombination (GO:0010569)3.53177696
54regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.51948399
55regulation of mitotic spindle checkpoint (GO:1903504)3.51948399
56folic acid-containing compound biosynthetic process (GO:0009396)3.49637429
57regulation of chromosome segregation (GO:0051983)3.48175723
58somatic hypermutation of immunoglobulin genes (GO:0016446)3.45649472
59somatic diversification of immune receptors via somatic mutation (GO:0002566)3.45649472
60protein K6-linked ubiquitination (GO:0085020)3.44922771
61purine nucleobase biosynthetic process (GO:0009113)3.44701429
62negative regulation of DNA recombination (GO:0045910)3.44425106
63chromosome segregation (GO:0007059)3.42973899
64regulation of sister chromatid cohesion (GO:0007063)3.42633294
65chromatin assembly or disassembly (GO:0006333)3.41560062
66negative regulation of chromosome segregation (GO:0051985)3.41394072
67regulation of mitotic metaphase/anaphase transition (GO:0030071)3.40631662
68regulation of centrosome duplication (GO:0010824)3.38813004
69maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.38757772
70spindle assembly checkpoint (GO:0071173)3.37492229
71negative regulation of mitotic sister chromatid separation (GO:2000816)3.36530079
72negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36530079
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36530079
74negative regulation of sister chromatid segregation (GO:0033046)3.36530079
75regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.33592881
76telomere maintenance via telomere lengthening (GO:0010833)3.31756981
77mitotic spindle assembly checkpoint (GO:0007094)3.31334636
78regulation of telomere maintenance via telomerase (GO:0032210)3.30426071
79mitotic spindle checkpoint (GO:0071174)3.30266078
80regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.30222883
81regulation of histone H3-K9 methylation (GO:0051570)3.27793401
82negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.27541704
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.26586156
84positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.26586156
85positive regulation of mitotic sister chromatid separation (GO:1901970)3.26586156
86regulation of centrosome cycle (GO:0046605)3.26360198
87establishment of integrated proviral latency (GO:0075713)3.25552541
88regulation of DNA endoreduplication (GO:0032875)3.25248178
89DNA ligation (GO:0006266)3.24605968
90nucleotide-excision repair, DNA gap filling (GO:0006297)3.23794821
91regulation of mitotic sister chromatid separation (GO:0010965)3.23726657
92regulation of mitotic sister chromatid segregation (GO:0033047)3.23726657
93regulation of sister chromatid segregation (GO:0033045)3.23726657
94negative regulation of histone methylation (GO:0031061)3.23264384
95regulation of double-strand break repair (GO:2000779)3.22915267
96ribosome assembly (GO:0042255)3.22862307
97ribosome biogenesis (GO:0042254)3.20880351
98formation of translation preinitiation complex (GO:0001731)3.19171105
99IMP metabolic process (GO:0046040)3.18740363
100DNA conformation change (GO:0071103)3.17588895
101ATP-dependent chromatin remodeling (GO:0043044)3.17207293
102sister chromatid cohesion (GO:0007062)3.15910245
103nuclear envelope organization (GO:0006998)3.14740827
104mismatch repair (GO:0006298)3.13826464
105regulation of RNA export from nucleus (GO:0046831)3.13785885
106regulation of nuclear cell cycle DNA replication (GO:0033262)3.11705278
107paraxial mesoderm development (GO:0048339)3.08809834
108regulation of helicase activity (GO:0051095)3.08732503
109maturation of SSU-rRNA (GO:0030490)3.07884751
110translesion synthesis (GO:0019985)3.07071792
111negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06053458
112replication fork processing (GO:0031297)3.05869009
113somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.04648430
114somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.04648430
115isotype switching (GO:0045190)3.04648430
116dosage compensation (GO:0007549)3.04300275
117chromosome condensation (GO:0030261)3.03348047
118DNA strand renaturation (GO:0000733)3.00413016
119response to X-ray (GO:0010165)2.99771949
120proteasome assembly (GO:0043248)2.98279548
121RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.97540910
122prenylation (GO:0097354)2.97169839
123protein prenylation (GO:0018342)2.97169839
124mitochondrial DNA replication (GO:0006264)2.96151535
125telomere maintenance (GO:0000723)2.94223661
126DNA topological change (GO:0006265)2.91344874
127dorsal/ventral axis specification (GO:0009950)2.87459943
128resolution of meiotic recombination intermediates (GO:0000712)2.87308258
129somatic recombination of immunoglobulin gene segments (GO:0016447)2.85332039
130synapsis (GO:0007129)2.83617618
131regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.83581867
132centriole replication (GO:0007099)2.82372307
133anterior/posterior axis specification, embryo (GO:0008595)2.81306674
134DNA-dependent DNA replication (GO:0006261)2.76777607
135telomere maintenance via telomerase (GO:0007004)2.74298503
136postreplication repair (GO:0006301)2.73490521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.60632767
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.44935777
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.91074656
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.70544874
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.81483014
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81311479
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74980270
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63556232
9AR_21909140_ChIP-Seq_LNCAP_Human2.61620480
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.45750099
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.39746812
12* FUS_26573619_Chip-Seq_HEK293_Human2.39681432
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34709942
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32541719
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.29250667
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28783223
17* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28176114
18EWS_26573619_Chip-Seq_HEK293_Human2.20482344
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.19415355
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11784735
21XRN2_22483619_ChIP-Seq_HELA_Human2.10093242
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03304149
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03223673
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.02430296
25E2F7_22180533_ChIP-Seq_HELA_Human10.6403843
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.98129272
27* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95332506
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.89694316
29VDR_23849224_ChIP-Seq_CD4+_Human1.89162288
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87079741
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80792534
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.80380314
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77852786
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76427874
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74078634
36MYC_22102868_ChIP-Seq_BL_Human1.73537506
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72073913
38IGF1R_20145208_ChIP-Seq_DFB_Human1.69939500
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69407869
40FOXP3_21729870_ChIP-Seq_TREG_Human1.69081102
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68786243
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65403032
43TAF15_26573619_Chip-Seq_HEK293_Human1.63941800
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.62325935
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.61603472
46TTF2_22483619_ChIP-Seq_HELA_Human1.59780727
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58720112
48ZNF274_21170338_ChIP-Seq_K562_Hela1.56847289
49* P300_19829295_ChIP-Seq_ESCs_Human1.55800179
50DCP1A_22483619_ChIP-Seq_HELA_Human1.54331213
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53335632
52* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53078341
53* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51562238
54ELK1_19687146_ChIP-ChIP_HELA_Human1.50758437
55CIITA_25753668_ChIP-Seq_RAJI_Human1.50311079
56GABP_19822575_ChIP-Seq_HepG2_Human1.49831721
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.49312022
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.48111974
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44867775
60KDM5A_27292631_Chip-Seq_BREAST_Human1.43300515
61VDR_22108803_ChIP-Seq_LS180_Human1.42455497
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.40720168
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39658044
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39658044
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39658044
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36997506
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36484138
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35514303
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33255724
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33226820
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33074870
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31912815
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31851906
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28258642
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28128120
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27869760
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26763051
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23856020
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23645965
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21256544
81IRF1_19129219_ChIP-ChIP_H3396_Human1.20512736
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19446350
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18328482
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18242712
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18140770
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.15823722
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14777342
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14527914
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13912111
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.12374146
91* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11895024
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11161308
93* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10999093
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07991841
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.07886539
96TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06634139
97GBX2_23144817_ChIP-Seq_PC3_Human1.05308046
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05161929
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04844277
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04578224
101TFEB_21752829_ChIP-Seq_HELA_Human1.04144320
102FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03030282
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01877420
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01229619
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00913897
106NANOG_21062744_ChIP-ChIP_HESCs_Human1.00280629
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98557357
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97273817
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97047982
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96940329
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95554875
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94914817
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94586194
114SMAD3_21741376_ChIP-Seq_EPCs_Human0.93390147
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93363821
116TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93195196
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93175936
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93061172
119PIAS1_25552417_ChIP-Seq_VCAP_Human0.92894609
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.92761784
121ER_23166858_ChIP-Seq_MCF-7_Human0.92312054
122* MYC_18940864_ChIP-ChIP_HL60_Human0.91908521
123SRF_21415370_ChIP-Seq_HL-1_Mouse0.91436050
124HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91207230
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.91067943
126ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90326741
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90229807
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88329316
129ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87824641
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87065282
131TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86616757
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85937342
133NOTCH1_21737748_ChIP-Seq_TLL_Human0.85773298
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85694248
135NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.85591244
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85517690
137BCAT_22108803_ChIP-Seq_LS180_Human0.85464821
138TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85389847
139UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84676636
140TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84342425
141* SOX9_26525672_Chip-Seq_HEART_Mouse0.83774288
142SMAD4_21799915_ChIP-Seq_A2780_Human0.82511737
143KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81788795
144BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81627555
145SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81418805
146VDR_21846776_ChIP-Seq_THP-1_Human0.81263721
147ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81133955
148GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80185643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.23103679
2MP0010094_abnormal_chromosome_stability4.98491194
3MP0003111_abnormal_nucleus_morphology4.56760498
4MP0004957_abnormal_blastocyst_morpholog4.37112599
5MP0008057_abnormal_DNA_replication4.28539136
6MP0003077_abnormal_cell_cycle4.10838733
7MP0006054_spinal_hemorrhage3.04244520
8MP0008058_abnormal_DNA_repair3.02391668
9MP0008007_abnormal_cellular_replicative2.92055149
10MP0000350_abnormal_cell_proliferation2.51294445
11MP0001730_embryonic_growth_arrest2.50063237
12MP0003123_paternal_imprinting2.46961855
13MP0008932_abnormal_embryonic_tissue2.45689727
14MP0008877_abnormal_DNA_methylation2.37780845
15MP0010307_abnormal_tumor_latency2.26000535
16MP0002396_abnormal_hematopoietic_system2.19534906
17MP0010352_gastrointestinal_tract_polyps2.12966742
18MP0002653_abnormal_ependyma_morphology1.99828066
19MP0001672_abnormal_embryogenesis/_devel1.99060347
20MP0005380_embryogenesis_phenotype1.99060347
21MP0001697_abnormal_embryo_size1.97746380
22MP0002085_abnormal_embryonic_tissue1.83114179
23MP0002938_white_spotting1.80064716
24MP0002084_abnormal_developmental_patter1.76512862
25MP0003984_embryonic_growth_retardation1.74801405
26MP0002088_abnormal_embryonic_growth/wei1.72270728
27MP0002086_abnormal_extraembryonic_tissu1.71844167
28MP0002080_prenatal_lethality1.64243337
29MP0002254_reproductive_system_inflammat1.63226823
30MP0004197_abnormal_fetal_growth/weight/1.62678534
31MP0004808_abnormal_hematopoietic_stem1.59553060
32MP0005076_abnormal_cell_differentiation1.58416949
33MP0003786_premature_aging1.57605363
34MP0000490_abnormal_crypts_of1.55336723
35MP0003718_maternal_effect1.54872674
36MP0003121_genomic_imprinting1.51793246
37MP0005394_taste/olfaction_phenotype1.49567273
38MP0005499_abnormal_olfactory_system1.49567273
39MP0000313_abnormal_cell_death1.48647725
40MP0003890_abnormal_embryonic-extraembry1.48421947
41MP0006072_abnormal_retinal_apoptosis1.45804603
42MP0001293_anophthalmia1.40834534
43MP0002019_abnormal_tumor_incidence1.39598707
44MP0002210_abnormal_sex_determination1.39277182
45MP0002233_abnormal_nose_morphology1.37611514
46MP0003567_abnormal_fetal_cardiomyocyte1.35135538
47MP0009672_abnormal_birth_weight1.34553486
48MP0001984_abnormal_olfaction1.30446192
49MP0000569_abnormal_digit_pigmentation1.30279017
50MP0000647_abnormal_sebaceous_gland1.29712680
51MP0003385_abnormal_body_wall1.26137079
52MP0009053_abnormal_anal_canal1.23608280
53MP0005187_abnormal_penis_morphology1.21240475
54MP0008789_abnormal_olfactory_epithelium1.20590497
55MP0001145_abnormal_male_reproductive1.18645551
56MP0009703_decreased_birth_body1.17142593
57MP0003119_abnormal_digestive_system1.16977948
58MP0001545_abnormal_hematopoietic_system1.15030688
59MP0005397_hematopoietic_system_phenotyp1.15030688
60MP0001929_abnormal_gametogenesis1.13458888
61MP0006292_abnormal_olfactory_placode1.11848740
62MP0003705_abnormal_hypodermis_morpholog1.11631290
63MP0000653_abnormal_sex_gland1.11210103
64MP0003122_maternal_imprinting1.10636967
65MP0003937_abnormal_limbs/digits/tail_de1.09572489
66MP0010030_abnormal_orbit_morphology1.08471024
67MP0002160_abnormal_reproductive_system1.07953663
68MP0000703_abnormal_thymus_morphology1.07235133
69MP0003315_abnormal_perineum_morphology1.06856291
70MP0003943_abnormal_hepatobiliary_system1.06118003
71MP0000372_irregular_coat_pigmentation1.05212383
72MP0003763_abnormal_thymus_physiology1.04112145
73MP0001119_abnormal_female_reproductive1.03955721
74MP0003941_abnormal_skin_development1.03487913
75MP0002751_abnormal_autonomic_nervous1.02923046
76MP0001299_abnormal_eye_distance/1.02617878
77MP0001661_extended_life_span1.02316550
78MP0005391_vision/eye_phenotype1.01179988
79MP0006035_abnormal_mitochondrial_morpho1.00536295
80MP0001177_atelectasis1.00333309
81MP0004147_increased_porphyrin_level0.98540875
82MP0002398_abnormal_bone_marrow0.95698307
83MP0001666_abnormal_nutrient_absorption0.94294038
84MP0005075_abnormal_melanosome_morpholog0.93814493
85MP0005248_abnormal_Harderian_gland0.93460441
86MP0005220_abnormal_exocrine_pancreas0.91982838
87MP0009333_abnormal_splenocyte_physiolog0.91113180
88MP0003136_yellow_coat_color0.90448375
89MP0004272_abnormal_basement_membrane0.89643747
90MP0009697_abnormal_copulation0.88182449
91MP0002092_abnormal_eye_morphology0.87859004
92MP0000427_abnormal_hair_cycle0.87544341
93MP0005253_abnormal_eye_physiology0.87215855
94MP0004133_heterotaxia0.87106053
95MP0001188_hyperpigmentation0.86565757
96MP0001915_intracranial_hemorrhage0.86373326
97MP0002722_abnormal_immune_system0.85656841
98MP0002111_abnormal_tail_morphology0.84751878
99MP0005623_abnormal_meninges_morphology0.83409199
100MP0000689_abnormal_spleen_morphology0.83359059
101MP0005621_abnormal_cell_physiology0.80432503
102MP0002282_abnormal_trachea_morphology0.79667460
103MP0005395_other_phenotype0.79355101
104MP0009250_abnormal_appendicular_skeleto0.78890331
105MP0005384_cellular_phenotype0.77942972
106MP0001286_abnormal_eye_development0.76991713
107MP0004264_abnormal_extraembryonic_tissu0.76739964
108MP0005408_hypopigmentation0.76566538
109MP0009278_abnormal_bone_marrow0.75863617
110MP0000733_abnormal_muscle_development0.74986643
111MP0003115_abnormal_respiratory_system0.74279523
112MP0003935_abnormal_craniofacial_develop0.73004483
113MP0003699_abnormal_female_reproductive0.71428885
114MP0001849_ear_inflammation0.68790440
115MP0000432_abnormal_head_morphology0.68156920
116MP0003806_abnormal_nucleotide_metabolis0.67175161
117MP0002095_abnormal_skin_pigmentation0.65945300
118MP0005367_renal/urinary_system_phenotyp0.65041856
119MP0000516_abnormal_urinary_system0.65041856
120MP0002429_abnormal_blood_cell0.64091373
121MP0003787_abnormal_imprinting0.63705433
122MP0002009_preneoplasia0.63685597
123MP0002697_abnormal_eye_size0.63674301
124MP0002006_tumorigenesis0.63239536
125MP0000537_abnormal_urethra_morphology0.62813508
126MP0000477_abnormal_intestine_morphology0.62272825
127MP0003221_abnormal_cardiomyocyte_apopto0.62141499
128MP0002925_abnormal_cardiovascular_devel0.60744045
129MP0003755_abnormal_palate_morphology0.60573952
130MP0000371_diluted_coat_color0.59816655
131MP0003861_abnormal_nervous_system0.59181570
132MP0002075_abnormal_coat/hair_pigmentati0.58953739
133MP0000428_abnormal_craniofacial_morphol0.58371257
134MP0002102_abnormal_ear_morphology0.55618086
135MP0000358_abnormal_cell_content/0.54571558
136MP0000858_altered_metastatic_potential0.53901555
137MP0003566_abnormal_cell_adhesion0.53820423
138MP0003448_altered_tumor_morphology0.53195439
139MP0000716_abnormal_immune_system0.53159293

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.73607381
2Birth length less than 3rd percentile (HP:0003561)4.70916689
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.51177511
4Breast hypoplasia (HP:0003187)3.74261610
5Aplasia/Hypoplasia of the patella (HP:0006498)3.72610614
6Abnormality of the anterior horn cell (HP:0006802)3.69766757
7Degeneration of anterior horn cells (HP:0002398)3.69766757
8Medulloblastoma (HP:0002885)3.63007013
9Abnormality of chromosome stability (HP:0003220)3.60880022
10Impulsivity (HP:0100710)3.60096635
11Ependymoma (HP:0002888)3.59321531
12Patellar aplasia (HP:0006443)3.49228959
13Colon cancer (HP:0003003)3.45529481
14Abnormality of the labia minora (HP:0012880)3.36583471
15Meckel diverticulum (HP:0002245)3.34378032
16Facial hemangioma (HP:0000329)3.24503432
17Bifid tongue (HP:0010297)3.21963762
18Abnormality of the preputium (HP:0100587)3.17556457
19Abnormality of the ileum (HP:0001549)3.14093115
20Aplasia/Hypoplasia of the uvula (HP:0010293)3.09743355
21Rhabdomyosarcoma (HP:0002859)3.09430552
22Selective tooth agenesis (HP:0001592)3.08027242
23Reticulocytopenia (HP:0001896)3.04935070
24Myelodysplasia (HP:0002863)2.99484196
25Volvulus (HP:0002580)2.98593278
26Ectopic kidney (HP:0000086)2.96143208
27Intestinal atresia (HP:0011100)2.95737146
28Basal cell carcinoma (HP:0002671)2.93340164
29Oral leukoplakia (HP:0002745)2.90035108
30Agnosia (HP:0010524)2.84464825
31Rib fusion (HP:0000902)2.84142273
32Absent radius (HP:0003974)2.82951047
33Duodenal stenosis (HP:0100867)2.80980225
34Small intestinal stenosis (HP:0012848)2.80980225
35Supernumerary spleens (HP:0009799)2.72845751
36Carpal bone hypoplasia (HP:0001498)2.70371365
37Absent forearm bone (HP:0003953)2.64328079
38Aplasia involving forearm bones (HP:0009822)2.64328079
39Absent thumb (HP:0009777)2.64130774
40Aplastic anemia (HP:0001915)2.56136342
41Proximal placement of thumb (HP:0009623)2.55192247
42Increased nuchal translucency (HP:0010880)2.53949835
43Abnormal lung lobation (HP:0002101)2.51521019
44Neoplasm of the oral cavity (HP:0100649)2.50873222
45Neoplasm of the adrenal cortex (HP:0100641)2.47077215
46Abnormality of methionine metabolism (HP:0010901)2.46075841
47Deviation of the thumb (HP:0009603)2.45735223
48Hyperglycinemia (HP:0002154)2.44135793
49Sloping forehead (HP:0000340)2.43126364
50Nephroblastoma (Wilms tumor) (HP:0002667)2.41798885
51Neoplasm of striated muscle (HP:0009728)2.39140687
52Abnormal number of incisors (HP:0011064)2.38912816
53Neoplasm of the pancreas (HP:0002894)2.38440645
54Abnormality of the astrocytes (HP:0100707)2.37173336
55Astrocytoma (HP:0009592)2.37173336
56Abnormality of the duodenum (HP:0002246)2.35543461
57Biliary tract neoplasm (HP:0100574)2.33994659
58Cafe-au-lait spot (HP:0000957)2.33759319
59Prominent nose (HP:0000448)2.31495509
60Hepatoblastoma (HP:0002884)2.30782690
61Papillary thyroid carcinoma (HP:0002895)2.30283103
62Tubulointerstitial nephritis (HP:0001970)2.26755092
63Embryonal renal neoplasm (HP:0011794)2.25607353
64Abnormality of the carotid arteries (HP:0005344)2.25543999
65Squamous cell carcinoma (HP:0002860)2.25168309
66Bone marrow hypocellularity (HP:0005528)2.23551472
67Short thumb (HP:0009778)2.23235074
68Atresia of the external auditory canal (HP:0000413)2.22594300
69Septo-optic dysplasia (HP:0100842)2.21151092
70Horseshoe kidney (HP:0000085)2.18872560
71Aplasia/Hypoplasia of the tibia (HP:0005772)2.18696214
72Long eyelashes (HP:0000527)2.18545782
73Median cleft lip (HP:0000161)2.18297210
74Glioma (HP:0009733)2.18159321
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18155127
76Amaurosis fugax (HP:0100576)2.17618983
77Premature graying of hair (HP:0002216)2.16841377
78Aplasia/Hypoplasia of the sternum (HP:0006714)2.16224257
79Abnormality of serum amino acid levels (HP:0003112)2.15571954
80Short tibia (HP:0005736)2.15424342
81Abnormality of the parathyroid morphology (HP:0011766)2.13606439
82Abnormality of cells of the erythroid lineage (HP:0012130)2.10389385
83Pancreatic islet-cell hyperplasia (HP:0004510)2.10252294
84Atrophy/Degeneration involving motor neurons (HP:0007373)2.10213644
85Clubbing of toes (HP:0100760)2.10192332
86Gonadotropin excess (HP:0000837)2.09717395
87Short 4th metacarpal (HP:0010044)2.06369032
88Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06369032
89Methylmalonic acidemia (HP:0002912)2.04272176
90Abnormality of the fingertips (HP:0001211)2.04178079
91Hypoplastic pelvis (HP:0008839)2.03667088
92Tracheoesophageal fistula (HP:0002575)2.03035511
93Shawl scrotum (HP:0000049)2.02289896
94Abnormal number of erythroid precursors (HP:0012131)2.01829735
95Pseudobulbar signs (HP:0002200)2.01707047
96Molar tooth sign on MRI (HP:0002419)2.01144363
97Abnormality of midbrain morphology (HP:0002418)2.01144363
98Capillary hemangiomas (HP:0005306)2.00564059
99Anal stenosis (HP:0002025)2.00471881
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.00274497
101Triphalangeal thumb (HP:0001199)2.00153340
102Acute myeloid leukemia (HP:0004808)1.99200638
103Rough bone trabeculation (HP:0100670)1.98785057
104Abnormal pancreas size (HP:0012094)1.95070196
105Neoplasm of the small intestine (HP:0100833)1.94211756
106Neoplasm of the adrenal gland (HP:0100631)1.93614396
107Thyroid carcinoma (HP:0002890)1.92740564
108Gastrointestinal atresia (HP:0002589)1.92349848
109Sandal gap (HP:0001852)1.90510636
11011 pairs of ribs (HP:0000878)1.89344847
111Abnormal auditory evoked potentials (HP:0006958)1.89265363
112Embryonal neoplasm (HP:0002898)1.89170084
113Genital tract atresia (HP:0001827)1.88520410
114Cellular immunodeficiency (HP:0005374)1.85137737
115Microvesicular hepatic steatosis (HP:0001414)1.84998589
116Neoplasm of the colon (HP:0100273)1.84298510
117High pitched voice (HP:0001620)1.82919692
118Missing ribs (HP:0000921)1.82062946
119Absent eyebrow (HP:0002223)1.81252979
120Abnormality of DNA repair (HP:0003254)1.81248431
121Hypoglycemic seizures (HP:0002173)1.81233042
122Aplasia/hypoplasia of the humerus (HP:0006507)1.80723344
123Abnormality of alanine metabolism (HP:0010916)1.79724716
124Hyperalaninemia (HP:0003348)1.79724716
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79724716
126Malignant gastrointestinal tract tumors (HP:0006749)1.79518481
127Gastrointestinal carcinoma (HP:0002672)1.79518481
128Hemivertebrae (HP:0002937)1.78657212
129Microretrognathia (HP:0000308)1.77997451
130Myelomeningocele (HP:0002475)1.77157828
131Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.75753253
132Abdominal situs inversus (HP:0003363)1.74893377
133Abnormality of abdominal situs (HP:0011620)1.74893377
134Vaginal atresia (HP:0000148)1.74749424
135Ovarian neoplasm (HP:0100615)1.74015390
136Slender long bone (HP:0003100)1.73978839
137Choanal atresia (HP:0000453)1.73570679
138Lymphoma (HP:0002665)1.73404856
139Rectovaginal fistula (HP:0000143)1.72815371
140Rectal fistula (HP:0100590)1.72815371
141Thrombocytosis (HP:0001894)1.72604950
142Facial cleft (HP:0002006)1.71782742
143Type 2 muscle fiber atrophy (HP:0003554)1.71599105
144Stenosis of the external auditory canal (HP:0000402)1.70945390
145Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.70202150
146Microtia (HP:0008551)1.70133290
147Patchy hypopigmentation of hair (HP:0011365)1.66416325
148Renal hypoplasia (HP:0000089)1.65527766
149Nephronophthisis (HP:0000090)1.61889018
150Enlarged kidneys (HP:0000105)1.61065214
151Preaxial foot polydactyly (HP:0001841)1.60616602
152Scrotal hypoplasia (HP:0000046)1.58833760
153Cortical dysplasia (HP:0002539)1.58222018
154Gonadal dysgenesis (HP:0000133)1.57921915
155Oculomotor apraxia (HP:0000657)1.57665829
156Decreased muscle mass (HP:0003199)1.57122213
157Astigmatism (HP:0000483)1.56838231
158Anal atresia (HP:0002023)1.56497273
159Bile duct proliferation (HP:0001408)1.55171400
160Abnormal biliary tract physiology (HP:0012439)1.55171400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.86860635
2WEE14.23076117
3NEK23.94633229
4BUB13.25229046
5CDK122.99042006
6TRIM282.89654098
7BMPR1B2.78293444
8SRPK12.77294101
9BRSK22.62534099
10TTK2.60985994
11MKNK12.57839781
12PBK2.48602451
13EIF2AK12.31709945
14PLK12.31257848
15PLK42.22320238
16CHEK22.15484885
17MKNK22.09952216
18MST42.07789725
19ACVR1B2.02580616
20NEK11.99068222
21WNK31.92713895
22TNIK1.89930304
23RPS6KA41.89909146
24CDK71.87639228
25AURKB1.87615270
26CDK41.78018675
27ATR1.78007271
28PLK31.68460711
29DYRK31.64989523
30FRK1.64650793
31TSSK61.58535482
32BCR1.57428657
33CHEK11.55446206
34LATS11.48710220
35CDK61.47964002
36BRSK11.47958411
37MAP3K81.45335633
38STK101.42717248
39AKT31.40301986
40AURKA1.39481624
41PASK1.38315955
42EEF2K1.37817576
43RPS6KB21.34463173
44MAP4K21.29607958
45EIF2AK31.29579480
46TLK11.29422829
47ATM1.26916908
48PDK21.25499711
49STK41.25442188
50VRK11.24694978
51TAF11.22829151
52STK31.19174594
53CDK81.15577616
54GRK11.13561829
55CDK21.09422310
56BRD41.08690356
57CASK1.07128809
58SCYL21.06344664
59MELK1.05102609
60LATS21.04936868
61NME21.03523067
62MAP3K101.02333495
63TGFBR10.99729770
64FGFR20.97422918
65EIF2AK20.95374623
66PIM10.94650938
67TESK20.94274646
68STK38L0.93170674
69PLK20.90876969
70ALK0.89811243
71CCNB10.88137253
72NLK0.84616848
73CDK10.81572096
74MAP3K40.81523875
75CSNK1G20.78887998
76CDK90.77502949
77FER0.73612769
78PAK40.71267102
79CSNK1G30.71180556
80PNCK0.70701628
81CSNK2A20.66795106
82STK390.66491852
83STK240.64743949
84MAPK130.60654986
85ZAK0.59331877
86JAK30.59305530
87CSNK1A1L0.59205941
88CSNK2A10.57503856
89RPS6KA50.57388521
90PKN20.56968438
91EPHA20.56576896
92YES10.54716868
93MAP3K60.52363125
94NUAK10.51561007
95MAP4K10.49076244
96PRKDC0.48010990
97MAP2K70.47709441
98MARK30.47479899
99PRKD30.47444469
100MTOR0.46382930
101CAMK1G0.45703288
102OXSR10.45325006
103CSNK1E0.44421191
104MAPK140.44194169
105PAK10.42066255
106PRKCE0.41012126
107SIK30.40245252
108RAF10.36667758
109NEK60.36380402
110CSNK1D0.35460396
111AKT10.32812499
112PRKCI0.31730151
113STK160.31514400
114BRAF0.30892163
115FLT30.30148899
116ERBB30.29942522
117MAPK10.29538581
118PRKACB0.27893791
119LRRK20.27714364
120GSK3B0.27274885
121MET0.26992530
122FGFR10.24458826
123CHUK0.23947794
124CDK30.23243248
125ERBB40.22347016
126TEC0.20957435
127RPS6KB10.20054591
128CSNK1G10.19507783
129ADRBK20.17281614
130GRK60.17183216
131MAPK110.17128075
132AKT20.14605601
133RPS6KA10.14473802
134MAPK100.14447170
135MAP2K30.14179811
136NEK90.12639324

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.96706555
2Mismatch repair_Homo sapiens_hsa034304.44816830
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.64622579
4Cell cycle_Homo sapiens_hsa041103.50439019
5Homologous recombination_Homo sapiens_hsa034403.42022512
6RNA transport_Homo sapiens_hsa030133.32306936
7Spliceosome_Homo sapiens_hsa030403.28108684
8Base excision repair_Homo sapiens_hsa034103.01752384
9Propanoate metabolism_Homo sapiens_hsa006402.96445517
10Protein export_Homo sapiens_hsa030602.95550583
11Nucleotide excision repair_Homo sapiens_hsa034202.88604130
12RNA polymerase_Homo sapiens_hsa030202.87163295
13Fanconi anemia pathway_Homo sapiens_hsa034602.77320122
14One carbon pool by folate_Homo sapiens_hsa006702.62868469
15Basal transcription factors_Homo sapiens_hsa030222.39871247
16Non-homologous end-joining_Homo sapiens_hsa034502.34395042
17mRNA surveillance pathway_Homo sapiens_hsa030152.28988718
18RNA degradation_Homo sapiens_hsa030182.11196355
19Ribosome_Homo sapiens_hsa030102.10356526
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03833409
21Pyrimidine metabolism_Homo sapiens_hsa002402.02609301
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96950235
23Steroid biosynthesis_Homo sapiens_hsa001001.95804616
24p53 signaling pathway_Homo sapiens_hsa041151.90075006
25Pyruvate metabolism_Homo sapiens_hsa006201.85039642
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69280112
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67999577
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62456394
29Proteasome_Homo sapiens_hsa030501.54054310
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48840984
31Oocyte meiosis_Homo sapiens_hsa041141.48829321
32Systemic lupus erythematosus_Homo sapiens_hsa053221.48579895
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41914556
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36606790
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30699338
36Fatty acid elongation_Homo sapiens_hsa000621.25740224
37Herpes simplex infection_Homo sapiens_hsa051681.23315634
38Viral carcinogenesis_Homo sapiens_hsa052031.13223016
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12864178
40Epstein-Barr virus infection_Homo sapiens_hsa051691.11026705
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08650844
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07735013
43MicroRNAs in cancer_Homo sapiens_hsa052061.06615564
44Purine metabolism_Homo sapiens_hsa002301.03296680
45Antigen processing and presentation_Homo sapiens_hsa046121.01908555
46Butanoate metabolism_Homo sapiens_hsa006501.01223549
47Vitamin B6 metabolism_Homo sapiens_hsa007500.98307666
48Fatty acid metabolism_Homo sapiens_hsa012120.96559257
49HTLV-I infection_Homo sapiens_hsa051660.92884379
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.90034305
51Thyroid cancer_Homo sapiens_hsa052160.89755826
52Fatty acid degradation_Homo sapiens_hsa000710.87384893
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86668157
54Selenocompound metabolism_Homo sapiens_hsa004500.84873867
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80827002
56Small cell lung cancer_Homo sapiens_hsa052220.77482121
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76272998
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75854751
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75630781
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74777372
61TGF-beta signaling pathway_Homo sapiens_hsa043500.73832466
62Peroxisome_Homo sapiens_hsa041460.67243195
63Hippo signaling pathway_Homo sapiens_hsa043900.66243877
64Biosynthesis of amino acids_Homo sapiens_hsa012300.64950158
65Pentose phosphate pathway_Homo sapiens_hsa000300.64195624
66Colorectal cancer_Homo sapiens_hsa052100.63010806
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60529037
68Alcoholism_Homo sapiens_hsa050340.59559761
69Notch signaling pathway_Homo sapiens_hsa043300.59268108
70N-Glycan biosynthesis_Homo sapiens_hsa005100.58514593
71Vitamin digestion and absorption_Homo sapiens_hsa049770.56889134
72Folate biosynthesis_Homo sapiens_hsa007900.56230375
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55567940
74mTOR signaling pathway_Homo sapiens_hsa041500.55123431
75Lysine degradation_Homo sapiens_hsa003100.53942297
76Basal cell carcinoma_Homo sapiens_hsa052170.53768777
77Hepatitis B_Homo sapiens_hsa051610.52349908
78Chronic myeloid leukemia_Homo sapiens_hsa052200.51828351
79Primary immunodeficiency_Homo sapiens_hsa053400.49883330
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49331013
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.48841495
82beta-Alanine metabolism_Homo sapiens_hsa004100.47786485
83Metabolic pathways_Homo sapiens_hsa011000.47453526
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47388304
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47326870
86Pancreatic cancer_Homo sapiens_hsa052120.47295675
87Adherens junction_Homo sapiens_hsa045200.45576702
88Prostate cancer_Homo sapiens_hsa052150.42618231
89Sulfur relay system_Homo sapiens_hsa041220.42511556
90Measles_Homo sapiens_hsa051620.38535109
91Apoptosis_Homo sapiens_hsa042100.38038282
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37886267
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.37877427
94Pathways in cancer_Homo sapiens_hsa052000.37669412
95Tryptophan metabolism_Homo sapiens_hsa003800.36150937
96Non-small cell lung cancer_Homo sapiens_hsa052230.35668763
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.35374404
98Fat digestion and absorption_Homo sapiens_hsa049750.34503893
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33882137
100Bladder cancer_Homo sapiens_hsa052190.33867112
101Regulation of autophagy_Homo sapiens_hsa041400.32813124
102Shigellosis_Homo sapiens_hsa051310.31532142
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30618298
104FoxO signaling pathway_Homo sapiens_hsa040680.30147557
105Viral myocarditis_Homo sapiens_hsa054160.29428774
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.29327554
107Phototransduction_Homo sapiens_hsa047440.28710711
108Legionellosis_Homo sapiens_hsa051340.28691960
109Hedgehog signaling pathway_Homo sapiens_hsa043400.27763506
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27756894
111Tight junction_Homo sapiens_hsa045300.26896310
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26862508
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25787243
114Wnt signaling pathway_Homo sapiens_hsa043100.24519274
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.24362205
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23866490
117Influenza A_Homo sapiens_hsa051640.23440177
118Circadian rhythm_Homo sapiens_hsa047100.21874976
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.20904381
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.20071185
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.20061440
122Acute myeloid leukemia_Homo sapiens_hsa052210.19714383
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19425761
124HIF-1 signaling pathway_Homo sapiens_hsa040660.18275626
125Endometrial cancer_Homo sapiens_hsa052130.18263369
126Olfactory transduction_Homo sapiens_hsa047400.17514940
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17145525
128Inositol phosphate metabolism_Homo sapiens_hsa005620.16172004
129Sphingolipid metabolism_Homo sapiens_hsa006000.15075615
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14912303
131Melanoma_Homo sapiens_hsa052180.14278854
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13663032
133Proteoglycans in cancer_Homo sapiens_hsa052050.13620703
134Retinol metabolism_Homo sapiens_hsa008300.13007596
135Ether lipid metabolism_Homo sapiens_hsa005650.12672636
136ABC transporters_Homo sapiens_hsa020100.12360444
137T cell receptor signaling pathway_Homo sapiens_hsa046600.11994055
138Glutathione metabolism_Homo sapiens_hsa004800.11376287
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09339557
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08907738
141Hematopoietic cell lineage_Homo sapiens_hsa046400.08500299
142Carbon metabolism_Homo sapiens_hsa012000.07658063
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.06935994
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.06203069

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