ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	meiotic chromosome segregation (GO:0045132)	5.82240765
2	regulation of memory T cell differentiation (GO:0043380)	5.14259505
3	rRNA catabolic process (GO:0016075)	5.11055420
4	C-terminal protein lipidation (GO:0006501)	4.90967943
5	preassembly of GPI anchor in ER membrane (GO:0016254)	4.80127690
6	C-terminal protein amino acid modification (GO:0018410)	4.64811770
7	cell wall macromolecule catabolic process (GO:0016998)	4.61092401
8	protein K11-linked deubiquitination (GO:0035871)	4.51848094
9	fatty acid elongation (GO:0030497)	4.22873699
10	adenosine metabolic process (GO:0046085)	4.21939036
11	peptidyl-threonine dephosphorylation (GO:0035970)	4.20257386
12	positive regulation of T cell cytokine production (GO:0002726)	4.13205781
13	positive regulation of prostaglandin secretion (GO:0032308)	4.03953971
14	cell wall macromolecule metabolic process (GO:0044036)	4.03144934
15	regulation of transmission of nerve impulse (GO:0051969)	3.85695558
16	protein deneddylation (GO:0000338)	3.84340246
17	ncRNA catabolic process (GO:0034661)	3.82473435
18	snRNA processing (GO:0016180)	3.78369039
19	cullin deneddylation (GO:0010388)	3.76327961
20	peptidyl-histidine modification (GO:0018202)	3.69542712
21	rRNA methylation (GO:0031167)	3.69182567
22	reciprocal meiotic recombination (GO:0007131)	3.60406817
23	reciprocal DNA recombination (GO:0035825)	3.60406817
24	regulation of meiosis I (GO:0060631)	3.58875468
25	mitochondrial RNA metabolic process (GO:0000959)	3.58469009
26	tryptophan catabolic process (GO:0006569)	3.57106284
27	indole-containing compound catabolic process (GO:0042436)	3.57106284
28	indolalkylamine catabolic process (GO:0046218)	3.57106284
29	negative regulation of DNA recombination (GO:0045910)	3.56209714
30	regulation of neuron projection regeneration (GO:0070570)	3.53727209
31	regulation of axon regeneration (GO:0048679)	3.53727209
32	histone mRNA metabolic process (GO:0008334)	3.51975149
33	acrosome assembly (GO:0001675)	3.30831209
34	mitochondrion degradation (GO:0000422)	3.30270237
35	iron-sulfur cluster assembly (GO:0016226)	3.30119421
36	metallo-sulfur cluster assembly (GO:0031163)	3.30119421
37	histone H2A acetylation (GO:0043968)	3.28455974
38	mismatch repair (GO:0006298)	3.27893844
39	rRNA modification (GO:0000154)	3.26419521
40	tryptophan metabolic process (GO:0006568)	3.21314137
41	regulation of prostaglandin secretion (GO:0032306)	3.21040344
42	kynurenine metabolic process (GO:0070189)	3.16987650
43	positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)	3.14588551
44	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.14131319
45	response to pheromone (GO:0019236)	3.10126699
46	cornea development in camera-type eye (GO:0061303)	3.09057866
47	snRNA metabolic process (GO:0016073)	3.08851951
48	regulation of heat generation (GO:0031650)	3.07930764
49	lysine metabolic process (GO:0006553)	3.07681275
50	lysine catabolic process (GO:0006554)	3.07681275
51	intraciliary transport (GO:0042073)	3.06999198
52	signal peptide processing (GO:0006465)	2.98695304
53	resolution of meiotic recombination intermediates (GO:0000712)	2.98302668
54	somite development (GO:0061053)	2.95361561
55	GPI anchor metabolic process (GO:0006505)	2.94858983
56	L-fucose catabolic process (GO:0042355)	2.93751330
57	fucose catabolic process (GO:0019317)	2.93751330
58	L-fucose metabolic process (GO:0042354)	2.93751330
59	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.91715324
60	mRNA cleavage (GO:0006379)	2.84606790
61	indolalkylamine metabolic process (GO:0006586)	2.83842585
62	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.82729520
63	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.82729520
64	male meiosis (GO:0007140)	2.82215831
65	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.81830133
66	folic acid metabolic process (GO:0046655)	2.81751610
67	termination of RNA polymerase I transcription (GO:0006363)	2.77124981
68	negative regulation of meiosis (GO:0045835)	2.76132034
69	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.75846130
70	DNA double-strand break processing (GO:0000729)	2.75663421
71	DNA ligation (GO:0006266)	2.75034346
72	negative regulation of defense response to virus (GO:0050687)	2.74394561
73	sleep (GO:0030431)	2.73865667
74	positive regulation of histone H3-K4 methylation (GO:0051571)	2.73454574
75	granulocyte differentiation (GO:0030851)	2.71806778
76	microtubule depolymerization (GO:0007019)	2.71640693
77	receptor recycling (GO:0001881)	2.70616941
78	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.67464973
79	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.67464973
80	isotype switching (GO:0045190)	2.67464973
81	monoubiquitinated protein deubiquitination (GO:0035520)	2.67028282
82	regulation of mitotic spindle checkpoint (GO:1903504)	2.63922612
83	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.63922612
84	cilium morphogenesis (GO:0060271)	2.63387333
85	protein neddylation (GO:0045116)	2.63261812
86	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.63017726
87	synapsis (GO:0007129)	2.61304250
88	auditory receptor cell stereocilium organization (GO:0060088)	2.59280844
89	GPI anchor biosynthetic process (GO:0006506)	2.57105578
90	positive regulation of heat generation (GO:0031652)	2.56831873
91	nephron tubule formation (GO:0072079)	2.56812130
92	aspartate family amino acid catabolic process (GO:0009068)	2.53938477
93	auditory behavior (GO:0031223)	2.51468580
94	spliceosomal snRNP assembly (GO:0000387)	2.50580920
95	meiosis I (GO:0007127)	2.48429235
96	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.48008199
97	negative regulation of B cell apoptotic process (GO:0002903)	2.47390343
98	coenzyme catabolic process (GO:0009109)	2.47192918
99	maturation of 5.8S rRNA (GO:0000460)	2.46518422
100	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.45406296

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	5.10729270
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.68176367
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.40168890
4	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.18979707
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.03241132
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.02232737
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.95702559
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.65520239
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.60439094
10	EWS_26573619_Chip-Seq_HEK293_Human	2.55536748
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.34044374
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.29832262
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.27621588
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.27377282
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.18725228
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.16478199
17	FUS_26573619_Chip-Seq_HEK293_Human	2.14488242
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06841111
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.02616137
20	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.94477785
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.87298750
22	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.77420701
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.77007212
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.75409979
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.73895279
26	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.73555121
27	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.71771129
28	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.68347875
29	VDR_22108803_ChIP-Seq_LS180_Human	1.64632987
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61335540
31	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.57795516
32	CIITA_25753668_ChIP-Seq_RAJI_Human	1.52089559
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.51797679
34	P300_19829295_ChIP-Seq_ESCs_Human	1.51251043
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.50617570
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.50422349
37	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.48042036
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43541526
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.41152792
40	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.40377633
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.38874008
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38845113
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.38845113
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.38718293
45	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.37640925
46	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36845753
47	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.35731541
48	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.34632056
49	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.33103033
50	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.32485151
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30990500
52	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30990500
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30549462
54	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.30101797
55	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.25086314
56	ER_23166858_ChIP-Seq_MCF-7_Human	1.25049560
57	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.24652198
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23845770
59	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.23731703
60	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.22540467
61	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21701014
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21275436
63	GABP_19822575_ChIP-Seq_HepG2_Human	1.19739265
64	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.17168852
65	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.17158222
66	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.16595404
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16352856
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15540481
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15496268
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15496268
71	RBPJ_21746931_ChIP-Seq_IB4_Human	1.14827423
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14759437
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14759437
74	DCP1A_22483619_ChIP-Seq_HELA_Human	1.14667185
75	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.14243465
76	TCF4_23295773_ChIP-Seq_U87_Human	1.13889319
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13784548
78	GBX2_23144817_ChIP-Seq_PC3_Human	1.13520324
79	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.12756443
80	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.12631681
81	HTT_18923047_ChIP-ChIP_STHdh_Human	1.12515289
82	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.10490031
83	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.10234396
84	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.10094048
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05549304
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05184872
87	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04126324
88	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01046912
89	GATA3_26560356_Chip-Seq_TH2_Human	0.99802199
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.99564380
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98796585
92	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.97189602
93	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96812815
94	PHF8_20622853_ChIP-Seq_HELA_Human	0.94074834
95	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.93833983
96	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.92804580
97	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.92427158
98	AR_20517297_ChIP-Seq_VCAP_Human	0.92216550
99	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.91861478
100	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.91129645

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	4.16423880
2	MP0005075_abnormal_melanosome_morpholog	3.13038118
3	MP0004782_abnormal_surfactant_physiolog	3.05333945
4	MP0000372_irregular_coat_pigmentation	3.00508155
5	MP0002736_abnormal_nociception_after	2.80482641
6	MP0004147_increased_porphyrin_level	2.79319423
7	MP0002254_reproductive_system_inflammat	2.67932583
8	MP0008058_abnormal_DNA_repair	2.57261373
9	MP0004381_abnormal_hair_follicle	2.40328244
10	MP0003806_abnormal_nucleotide_metabolis	2.22329780
11	MP0003786_premature_aging	2.20270327
12	MP0001986_abnormal_taste_sensitivity	2.19220589
13	MP0002102_abnormal_ear_morphology	2.14054607
14	MP0001968_abnormal_touch/_nociception	2.01629468
15	MP0001984_abnormal_olfaction	1.92216067
16	MP0004043_abnormal_pH_regulation	1.84239201
17	MP0005551_abnormal_eye_electrophysiolog	1.82453604
18	MP0006054_spinal_hemorrhage	1.78485041
19	MP0005310_abnormal_salivary_gland	1.77975193
20	MP0009697_abnormal_copulation	1.77272788
21	MP0005360_urolithiasis	1.76999248
22	MP0003011_delayed_dark_adaptation	1.72206091
23	MP0005408_hypopigmentation	1.66191021
24	MP0002876_abnormal_thyroid_physiology	1.64267078
25	MP0008875_abnormal_xenobiotic_pharmacok	1.60645708
26	MP0008995_early_reproductive_senescence	1.58645942
27	MP0010094_abnormal_chromosome_stability	1.56877049
28	MP0003718_maternal_effect	1.56479030
29	MP0005253_abnormal_eye_physiology	1.51859819
30	MP0003221_abnormal_cardiomyocyte_apopto	1.47717568
31	MP0001764_abnormal_homeostasis	1.46302099
32	MP0001502_abnormal_circadian_rhythm	1.43915722
33	MP0004484_altered_response_of	1.40601901
34	MP0002090_abnormal_vision	1.38653391
35	MP0000631_abnormal_neuroendocrine_gland	1.36791569
36	MP0002928_abnormal_bile_duct	1.36675898
37	MP0004957_abnormal_blastocyst_morpholog	1.36443111
38	MP0005671_abnormal_response_to	1.33621036
39	MP0001188_hyperpigmentation	1.30305363
40	MP0001727_abnormal_embryo_implantation	1.27991494
41	MP0005410_abnormal_fertilization	1.26636947
42	MP0000685_abnormal_immune_system	1.23833136
43	MP0003195_calcinosis	1.21285173
44	MP0008872_abnormal_physiological_respon	1.21082899
45	MP0004215_abnormal_myocardial_fiber	1.19126345
46	MP0009384_cardiac_valve_regurgitation	1.18149974
47	MP0001929_abnormal_gametogenesis	1.14391666
48	MP0003186_abnormal_redox_activity	1.12847439
49	MP0002638_abnormal_pupillary_reflex	1.11099416
50	MP0005332_abnormal_amino_acid	1.09563819
51	MP0008007_abnormal_cellular_replicative	1.08449157
52	MP0008961_abnormal_basal_metabolism	1.07889771
53	MP0003111_abnormal_nucleus_morphology	1.07701416
54	MP0001486_abnormal_startle_reflex	1.05070798
55	MP0003698_abnormal_male_reproductive	1.03749976
56	MP0004742_abnormal_vestibular_system	1.03748777
57	MP0004145_abnormal_muscle_electrophysio	1.01458893
58	MP0006035_abnormal_mitochondrial_morpho	1.01252462
59	MP0005646_abnormal_pituitary_gland	1.00754935
60	MP0002277_abnormal_respiratory_mucosa	0.99448406
61	MP0006072_abnormal_retinal_apoptosis	0.98553655
62	MP0005085_abnormal_gallbladder_physiolo	0.98064516
63	MP0000647_abnormal_sebaceous_gland	0.93000898
64	MP0002405_respiratory_system_inflammati	0.92368656
65	MP0003693_abnormal_embryo_hatching	0.92295075
66	MP0002166_altered_tumor_susceptibility	0.91469524
67	MP0001324_abnormal_eye_pigmentation	0.91231119
68	MP0005084_abnormal_gallbladder_morpholo	0.89474616
69	MP0002006_tumorigenesis	0.88025050
70	MP0000569_abnormal_digit_pigmentation	0.87948079
71	MP0003136_yellow_coat_color	0.87599503
72	MP0002210_abnormal_sex_determination	0.86328354
73	MP0008877_abnormal_DNA_methylation	0.84355097
74	MP0004133_heterotaxia	0.84035587
75	MP0002163_abnormal_gland_morphology	0.83386506
76	MP0009764_decreased_sensitivity_to	0.83213439
77	MP0003880_abnormal_central_pattern	0.81652846
78	MP0008260_abnormal_autophagy	0.81372903
79	MP0005167_abnormal_blood-brain_barrier	0.81364990
80	MP0000015_abnormal_ear_pigmentation	0.81096282
81	MP0005266_abnormal_metabolism	0.79577897
82	MP0001119_abnormal_female_reproductive	0.79329377
83	MP0000653_abnormal_sex_gland	0.79020761
84	MP0006276_abnormal_autonomic_nervous	0.77527689
85	MP0008932_abnormal_embryonic_tissue	0.77444777
86	MP0008873_increased_physiological_sensi	0.77247310
87	MP0002751_abnormal_autonomic_nervous	0.76412885
88	MP0004085_abnormal_heartbeat	0.75940874
89	MP0006036_abnormal_mitochondrial_physio	0.75757977
90	MP0002938_white_spotting	0.74349607
91	MP0002229_neurodegeneration	0.73488838
92	MP0001835_abnormal_antigen_presentation	0.73109568
93	MP0003724_increased_susceptibility_to	0.72912001
94	MP0001501_abnormal_sleep_pattern	0.71335454
95	MP0009115_abnormal_fat_cell	0.71051046
96	MP0002272_abnormal_nervous_system	0.70996249
97	MP0001485_abnormal_pinna_reflex	0.69328473
98	MP0001346_abnormal_lacrimal_gland	0.68687579
99	MP0002095_abnormal_skin_pigmentation	0.67483555
100	MP0000427_abnormal_hair_cycle	0.67163527

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.38972541
2	Septo-optic dysplasia (HP:0100842)	4.32817194
3	Pancreatic fibrosis (HP:0100732)	4.05710824
4	Medial flaring of the eyebrow (HP:0010747)	3.87901246
5	True hermaphroditism (HP:0010459)	3.87603224
6	Congenital primary aphakia (HP:0007707)	3.77437120
7	Gait imbalance (HP:0002141)	3.67765110
8	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.55356587
9	Abnormality of alanine metabolism (HP:0010916)	3.55356587
10	Hyperalaninemia (HP:0003348)	3.55356587
11	Abnormal biliary tract physiology (HP:0012439)	3.42525750
12	Bile duct proliferation (HP:0001408)	3.42525750
13	Nephrogenic diabetes insipidus (HP:0009806)	3.39152712
14	Abnormality of midbrain morphology (HP:0002418)	3.21663688
15	Molar tooth sign on MRI (HP:0002419)	3.21663688
16	Nephronophthisis (HP:0000090)	3.19769514
17	Attenuation of retinal blood vessels (HP:0007843)	3.14872777
18	Chronic hepatic failure (HP:0100626)	3.10623708
19	Renal cortical cysts (HP:0000803)	3.00152129
20	Occipital encephalocele (HP:0002085)	2.95910084
21	Abnormality of the renal cortex (HP:0011035)	2.93908100
22	Poor coordination (HP:0002370)	2.92730997
23	Optic nerve hypoplasia (HP:0000609)	2.92352283
24	Vaginal atresia (HP:0000148)	2.86642583
25	Severe combined immunodeficiency (HP:0004430)	2.86622130
26	Genital tract atresia (HP:0001827)	2.84373519
27	Chronic bronchitis (HP:0004469)	2.78053099
28	Cerebellar dysplasia (HP:0007033)	2.75953088
29	Tubular atrophy (HP:0000092)	2.60923695
30	Type II lissencephaly (HP:0007260)	2.60772304
31	Biliary tract neoplasm (HP:0100574)	2.59298648
32	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.58773496
33	Postaxial foot polydactyly (HP:0001830)	2.58715500
34	Abnormality of B cell number (HP:0010975)	2.55820737
35	Abnormality of the renal medulla (HP:0100957)	2.49905963
36	Cystic liver disease (HP:0006706)	2.45897640
37	Combined immunodeficiency (HP:0005387)	2.39039973
38	Decreased circulating renin level (HP:0003351)	2.37472692
39	Atonic seizures (HP:0010819)	2.36019902
40	Alveolar cell carcinoma (HP:0006519)	2.32944723
41	Decreased central vision (HP:0007663)	2.32099089
42	Thyroiditis (HP:0100646)	2.30268899
43	Clumsiness (HP:0002312)	2.28750346
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.28462110
45	IgG deficiency (HP:0004315)	2.28196581
46	3-Methylglutaconic aciduria (HP:0003535)	2.27909427
47	Absent septum pellucidum (HP:0001331)	2.26598638
48	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.25615213
49	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.25615213
50	B lymphocytopenia (HP:0010976)	2.25095395
51	Broad-based gait (HP:0002136)	2.23893814
52	Abnormality of the septum pellucidum (HP:0007375)	2.23018712
53	Abnormality of the sella turcica (HP:0002679)	2.22461558
54	Sclerocornea (HP:0000647)	2.21104364
55	Bronchitis (HP:0012387)	2.17143300
56	Supernumerary spleens (HP:0009799)	2.15842310
57	Neoplasm of the tracheobronchial system (HP:0100552)	2.14101879
58	Abnormality of T cell number (HP:0011839)	2.13827011
59	Hypoplasia of the thymus (HP:0000778)	2.13231986
60	Broad foot (HP:0001769)	2.12084218
61	Rhinitis (HP:0012384)	2.09612511
62	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.08898171
63	Abnormality of serum amino acid levels (HP:0003112)	2.08860413
64	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.06881590
65	Ependymoma (HP:0002888)	2.05348084
66	Polydipsia (HP:0001959)	2.03690154
67	Abnormal drinking behavior (HP:0030082)	2.03690154
68	Gaze-evoked nystagmus (HP:0000640)	2.02565588
69	Anencephaly (HP:0002323)	2.01365662
70	Abnormality of eosinophils (HP:0001879)	2.00639114
71	Abnormal rod and cone electroretinograms (HP:0008323)	1.98702095
72	Specific learning disability (HP:0001328)	1.96546759
73	Hypoproteinemia (HP:0003075)	1.96527035
74	Postaxial hand polydactyly (HP:0001162)	1.93154351
75	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.92163049
76	Progressive inability to walk (HP:0002505)	1.91642961
77	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.90950068
78	Hypomagnesemia (HP:0002917)	1.90697812
79	Aplasia/Hypoplasia of the lens (HP:0008063)	1.90120025
80	Retinitis pigmentosa (HP:0000510)	1.89554211
81	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.89102943
82	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.88483142
83	Stomach cancer (HP:0012126)	1.87117170
84	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.85863038
85	Primary adrenal insufficiency (HP:0008207)	1.85358885
86	Constricted visual fields (HP:0001133)	1.84937548
87	Increased serum lactate (HP:0002151)	1.83663140
88	Flat occiput (HP:0005469)	1.80261879
89	Abnormality of T cell physiology (HP:0011840)	1.79918493
90	Bony spicule pigmentary retinopathy (HP:0007737)	1.77686296
91	Congenital hepatic fibrosis (HP:0002612)	1.77094040
92	Neoplasm of the rectum (HP:0100743)	1.75530609
93	Recurrent bronchitis (HP:0002837)	1.75267813
94	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.73686887
95	Furrowed tongue (HP:0000221)	1.73337284
96	Hyperventilation (HP:0002883)	1.73228390
97	Congenital stationary night blindness (HP:0007642)	1.73018718
98	Oculomotor apraxia (HP:0000657)	1.72786829
99	Astigmatism (HP:0000483)	1.72698209
100	Abnormality of the anterior horn cell (HP:0006802)	1.69808732

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.85485248
2	MAP4K2	3.82319762
3	CASK	3.52453126
4	DYRK3	3.29130833
5	NUAK1	2.94233203
6	MKNK2	2.87154369
7	FRK	2.66945708
8	PRKD3	2.41561382
9	MKNK1	2.38921239
10	BLK	2.38006296
11	TAOK3	2.20974824
12	BCR	2.18909825
13	ACVR1B	2.14677390
14	FES	2.04901433
15	MST4	1.87221953
16	MAPKAPK3	1.81350104
17	EIF2AK3	1.78790298
18	SRPK1	1.76227461
19	TLK1	1.61874359
20	MAPK13	1.53851621
21	MAP3K5	1.52039458
22	BMPR1B	1.48195675
23	PBK	1.47573356
24	ADRBK2	1.42905793
25	MAP2K7	1.39336964
26	NEK2	1.39251221
27	RPS6KA4	1.32516976
28	NEK1	1.27934335
29	PLK3	1.24976772
30	WNK4	1.24521479
31	MAP3K4	1.20391278
32	WNK3	1.19392072
33	BMPR2	1.11419727
34	ERBB4	1.07834906
35	TRIM28	1.07758716
36	BUB1	1.02704545
37	VRK1	1.00664320
38	PINK1	0.96335761
39	CSNK1G3	0.94256491
40	LATS1	0.94036456
41	ATR	0.93060178
42	TXK	0.88061616
43	STK16	0.87456449
44	CCNB1	0.87172287
45	PLK1	0.86011683
46	TTK	0.80125312
47	CSNK1G2	0.78096084
48	CSNK1G1	0.77467473
49	WEE1	0.76426967
50	TNIK	0.74833496
51	EPHA4	0.73758547
52	OXSR1	0.72360968
53	PLK4	0.72116449
54	PLK2	0.69231985
55	GRK1	0.69202481
56	MARK3	0.66203744
57	STK38L	0.65566587
58	CSNK1A1L	0.65133685
59	TSSK6	0.64245000
60	CDK19	0.64148151
61	ERBB3	0.62490185
62	AKT3	0.61365325
63	NLK	0.59871618
64	PRKCQ	0.59805508
65	INSRR	0.58439657
66	ERBB2	0.56695420
67	MATK	0.56373316
68	PKN1	0.54163322
69	SIK3	0.51846530
70	IKBKB	0.50985155
71	CAMK1D	0.49145861
72	STK39	0.47629918
73	RPS6KA5	0.45802034
74	CAMK4	0.45090666
75	FER	0.44743978
76	BMX	0.43254688
77	MAPKAPK5	0.42355017
78	FLT3	0.41503176
79	MARK1	0.40898843
80	DYRK2	0.39851380
81	PIK3CG	0.39668204
82	CSNK1A1	0.39462650
83	AURKB	0.39037215
84	BRD4	0.37709580
85	TNK2	0.37327181
86	ATM	0.36960017
87	PIM1	0.36455653
88	MAP3K9	0.34833311
89	CAMK2A	0.34681757
90	PRKACB	0.34031384
91	CSNK2A1	0.33906143
92	CHUK	0.33206614
93	NEK6	0.33164652
94	PDK1	0.32138541
95	CSNK1E	0.31316618
96	PRKCE	0.31164102
97	MAP3K6	0.30935217
98	PAK3	0.29561415
99	ABL2	0.29111668
100	CAMK1	0.28952371

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.85799289
2	Proteasome_Homo sapiens_hsa03050	3.42105293
3	Non-homologous end-joining_Homo sapiens_hsa03450	3.02388489
4	Regulation of autophagy_Homo sapiens_hsa04140	2.98674588
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.96308356
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.73288086
7	Basal transcription factors_Homo sapiens_hsa03022	2.44075784
8	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.29898681
9	Propanoate metabolism_Homo sapiens_hsa00640	2.22229654
10	One carbon pool by folate_Homo sapiens_hsa00670	2.20729732
11	RNA polymerase_Homo sapiens_hsa03020	2.12288234
12	Mismatch repair_Homo sapiens_hsa03430	2.07651646
13	Primary immunodeficiency_Homo sapiens_hsa05340	1.92078652
14	Sulfur metabolism_Homo sapiens_hsa00920	1.90303614
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.84104988
16	Olfactory transduction_Homo sapiens_hsa04740	1.74895845
17	Protein export_Homo sapiens_hsa03060	1.72851429
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.69104095
19	RNA degradation_Homo sapiens_hsa03018	1.65140104
20	Fatty acid elongation_Homo sapiens_hsa00062	1.61927529
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.61264124
22	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.55112304
23	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.53605304
24	Alcoholism_Homo sapiens_hsa05034	1.50842228
25	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.49481694
26	Homologous recombination_Homo sapiens_hsa03440	1.45112564
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.37345923
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.35456320
29	RNA transport_Homo sapiens_hsa03013	1.35173784
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.34338704
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34091965
32	Phototransduction_Homo sapiens_hsa04744	1.32082027
33	Base excision repair_Homo sapiens_hsa03410	1.26825990
34	Spliceosome_Homo sapiens_hsa03040	1.25994334
35	Caffeine metabolism_Homo sapiens_hsa00232	1.25359673
36	Nicotine addiction_Homo sapiens_hsa05033	1.25155916
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.18471656
38	Graft-versus-host disease_Homo sapiens_hsa05332	1.18127351
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16874731
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.10302223
41	Fatty acid metabolism_Homo sapiens_hsa01212	1.09870235
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.08932422
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.08704889
44	Allograft rejection_Homo sapiens_hsa05330	1.07937230
45	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.06858924
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06361511
47	Fat digestion and absorption_Homo sapiens_hsa04975	1.00683725
48	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.99806027
49	Steroid biosynthesis_Homo sapiens_hsa00100	0.99423810
50	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.92842736
51	Pyruvate metabolism_Homo sapiens_hsa00620	0.91804320
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.91774440
53	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.90696370
54	Fatty acid degradation_Homo sapiens_hsa00071	0.87596425
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.87385966
56	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.86619866
57	mRNA surveillance pathway_Homo sapiens_hsa03015	0.86542686
58	Herpes simplex infection_Homo sapiens_hsa05168	0.83392595
59	Purine metabolism_Homo sapiens_hsa00230	0.82162197
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.77757981
61	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.77214662
62	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.76374643
63	Circadian rhythm_Homo sapiens_hsa04710	0.76109633
64	Sulfur relay system_Homo sapiens_hsa04122	0.74766311
65	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.74527216
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.73181153
67	Viral carcinogenesis_Homo sapiens_hsa05203	0.71979526
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.71392581
69	p53 signaling pathway_Homo sapiens_hsa04115	0.67422545
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.65500713
71	Oxidative phosphorylation_Homo sapiens_hsa00190	0.64261566
72	Butanoate metabolism_Homo sapiens_hsa00650	0.61261132
73	Peroxisome_Homo sapiens_hsa04146	0.58205791
74	Morphine addiction_Homo sapiens_hsa05032	0.54530255
75	Taste transduction_Homo sapiens_hsa04742	0.54297328
76	Huntingtons disease_Homo sapiens_hsa05016	0.53446287
77	Type I diabetes mellitus_Homo sapiens_hsa04940	0.52872315
78	Lysine degradation_Homo sapiens_hsa00310	0.51261165
79	Oocyte meiosis_Homo sapiens_hsa04114	0.50600083
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49432609
81	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.49378424
82	Cell cycle_Homo sapiens_hsa04110	0.47291164
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.45529943
84	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.45335035
85	DNA replication_Homo sapiens_hsa03030	0.43891102
86	Parkinsons disease_Homo sapiens_hsa05012	0.43793710
87	Metabolic pathways_Homo sapiens_hsa01100	0.43163364
88	Antigen processing and presentation_Homo sapiens_hsa04612	0.42631144
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40412072
90	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.37921598
91	Renin-angiotensin system_Homo sapiens_hsa04614	0.37507955
92	Chemical carcinogenesis_Homo sapiens_hsa05204	0.36083345
93	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.32322971
94	Measles_Homo sapiens_hsa05162	0.31883521
95	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.30331627
96	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.30044108
97	Glutathione metabolism_Homo sapiens_hsa00480	0.29846442
98	PPAR signaling pathway_Homo sapiens_hsa03320	0.29053497
99	Retinol metabolism_Homo sapiens_hsa00830	0.28987745
100	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.28767614

ETF1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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