ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	5.56124818
2	behavioral response to nicotine (GO:0035095)	5.45164223
3	adult feeding behavior (GO:0008343)	5.06795825
4	water-soluble vitamin biosynthetic process (GO:0042364)	5.06050566
5	negative regulation of interleukin-1 beta production (GO:0032691)	4.98686673
6	indolalkylamine metabolic process (GO:0006586)	4.54841889
7	positive regulation of sodium ion transmembrane transport (GO:1902307)	4.51731352
8	DNA deamination (GO:0045006)	4.31444711
9	negative regulation of interleukin-1 production (GO:0032692)	4.27075396
10	adaptation of signaling pathway (GO:0023058)	4.20272378
11	indolalkylamine catabolic process (GO:0046218)	4.08620649
12	tryptophan catabolic process (GO:0006569)	4.08620649
13	indole-containing compound catabolic process (GO:0042436)	4.08620649
14	growth hormone secretion (GO:0030252)	4.07918831
15	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	4.03895308
16	kynurenine metabolic process (GO:0070189)	3.89286370
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.85748772
18	hindbrain development (GO:0030902)	3.83120542
19	L-fucose catabolic process (GO:0042355)	3.74474759
20	fucose catabolic process (GO:0019317)	3.74474759
21	L-fucose metabolic process (GO:0042354)	3.74474759
22	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	3.65351068
23	auditory receptor cell stereocilium organization (GO:0060088)	3.62378821
24	tryptophan metabolic process (GO:0006568)	3.55207067
25	negative regulation of telomere maintenance (GO:0032205)	3.53830855
26	regulation of cilium movement (GO:0003352)	3.53464024
27	regulation of response to food (GO:0032095)	3.50523045
28	platelet dense granule organization (GO:0060155)	3.49308879
29	multicellular organism reproduction (GO:0032504)	3.45611090
30	regulation of appetite (GO:0032098)	3.40677164
31	indole-containing compound metabolic process (GO:0042430)	3.40365326
32	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.33269838
33	response to pheromone (GO:0019236)	3.19539170
34	protein complex biogenesis (GO:0070271)	3.17444904
35	piRNA metabolic process (GO:0034587)	3.15733108
36	protein import into peroxisome matrix (GO:0016558)	3.12163974
37	inner ear receptor stereocilium organization (GO:0060122)	3.09918201
38	regulation of interleukin-6 biosynthetic process (GO:0045408)	3.07386354
39	mitochondrial respiratory chain complex assembly (GO:0033108)	3.04977018
40	neuronal action potential (GO:0019228)	3.04893977
41	respiratory chain complex IV assembly (GO:0008535)	3.03865090
42	nephron epithelium morphogenesis (GO:0072088)	3.02644588
43	nephron tubule morphogenesis (GO:0072078)	3.02644588
44	cytochrome complex assembly (GO:0017004)	3.01725053
45	sulfation (GO:0051923)	3.01349127
46	NAD biosynthetic process (GO:0009435)	3.00375088
47	protein polyglutamylation (GO:0018095)	3.00012130
48	protein K11-linked deubiquitination (GO:0035871)	2.94776833
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.82626533
50	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.82626533
51	NADH dehydrogenase complex assembly (GO:0010257)	2.82626533
52	spinal cord development (GO:0021510)	2.80318231
53	response to food (GO:0032094)	2.79948668
54	glycerophospholipid catabolic process (GO:0046475)	2.79499672
55	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.78737552
56	amine catabolic process (GO:0009310)	2.78045988
57	cellular biogenic amine catabolic process (GO:0042402)	2.78045988
58	somite development (GO:0061053)	2.76789856
59	negative regulation of T cell differentiation in thymus (GO:0033085)	2.72811509
60	cornea development in camera-type eye (GO:0061303)	2.72462850
61	axoneme assembly (GO:0035082)	2.71847078
62	negative regulation of mast cell activation (GO:0033004)	2.71603480
63	sperm motility (GO:0030317)	2.69325806
64	axonemal dynein complex assembly (GO:0070286)	2.65941221
65	cilium organization (GO:0044782)	2.65924746
66	mannosylation (GO:0097502)	2.65452890
67	regulation of hexokinase activity (GO:1903299)	2.64027403
68	regulation of glucokinase activity (GO:0033131)	2.64027403
69	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.61082216
70	one-carbon compound transport (GO:0019755)	2.60067385
71	ATP synthesis coupled proton transport (GO:0015986)	2.58700564
72	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.58700564
73	endocrine pancreas development (GO:0031018)	2.56669806
74	nonmotile primary cilium assembly (GO:0035058)	2.54491195
75	detection of light stimulus involved in sensory perception (GO:0050962)	2.53790596
76	detection of light stimulus involved in visual perception (GO:0050908)	2.53790596
77	pseudouridine synthesis (GO:0001522)	2.53599182
78	kidney morphogenesis (GO:0060993)	2.52733879
79	positive regulation of defense response to virus by host (GO:0002230)	2.52503469
80	DNA demethylation (GO:0080111)	2.50928344
81	regulation of microtubule-based movement (GO:0060632)	2.50107211
82	gamma-aminobutyric acid transport (GO:0015812)	2.49562711
83	neuron fate determination (GO:0048664)	2.49134304
84	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.48286947
85	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.47521120
86	cysteine metabolic process (GO:0006534)	2.47128379
87	behavioral response to ethanol (GO:0048149)	2.46746946
88	preassembly of GPI anchor in ER membrane (GO:0016254)	2.46692731
89	cilium assembly (GO:0042384)	2.46166558
90	intracellular protein transmembrane import (GO:0044743)	2.46105928
91	regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)	2.45578043
92	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.45385436
93	rRNA catabolic process (GO:0016075)	2.45242800
94	neural tube formation (GO:0001841)	2.43499618
95	positive regulation of fatty acid transport (GO:2000193)	2.43150788
96	vitamin biosynthetic process (GO:0009110)	2.42129491
97	cellular ketone body metabolic process (GO:0046950)	2.40464601
98	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.38023924
99	positive thymic T cell selection (GO:0045059)	2.36913930
100	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.36201167

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.53937683
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.06119847
3	VDR_22108803_ChIP-Seq_LS180_Human	3.20230874
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.89278852
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.65270179
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.49354549
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.37686056
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.36143718
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.30077690
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.18254263
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.15797124
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14159860
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08906602
14	FUS_26573619_Chip-Seq_HEK293_Human	2.06332815
15	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.05564099
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.01584413
17	P300_19829295_ChIP-Seq_ESCs_Human	2.01510218
18	EWS_26573619_Chip-Seq_HEK293_Human	1.95123957
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.85256577
20	AR_21572438_ChIP-Seq_LNCaP_Human	1.76639337
21	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.74643601
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73461617
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.73438862
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.71132455
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.69032811
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.68756672
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.61816811
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59889359
29	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.59821847
30	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.59678761
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.53231571
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46445412
33	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.46445412
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.44962982
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.42361507
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.41427664
37	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.41246617
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.38513134
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.38499929
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.38478997
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.34752589
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34402245
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34402245
44	TAF15_26573619_Chip-Seq_HEK293_Human	1.34306554
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32826545
46	STAT3_23295773_ChIP-Seq_U87_Human	1.32442964
47	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32352221
48	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.32309191
49	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.30203640
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.28627573
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27786246
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27037071
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27037071
54	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.26954227
55	AR_25329375_ChIP-Seq_VCAP_Human	1.25982312
56	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25914113
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.24875907
58	TCF4_23295773_ChIP-Seq_U87_Human	1.22930634
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21980394
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.18211613
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18211613
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17320891
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17264381
64	VDR_23849224_ChIP-Seq_CD4+_Human	1.16977318
65	NCOR_22424771_ChIP-Seq_293T_Human	1.16840521
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16655474
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16245773
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16219431
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15557454
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14695950
71	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13786628
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13123158
73	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10387587
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10314037
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.09138433
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08436065
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.08363750
78	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.08036020
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07716976
80	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.05878298
81	AR_20517297_ChIP-Seq_VCAP_Human	1.05858629
82	TCF4_22108803_ChIP-Seq_LS180_Human	1.05711862
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05388360
84	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.04193382
85	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04015336
86	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03098391
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02873124
88	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02552454
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01927069
90	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.01673841
91	ELK1_19687146_ChIP-ChIP_HELA_Human	1.01489280
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.99904588
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99271098
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98973063
95	MYC_19829295_ChIP-Seq_ESCs_Human	0.97925650
96	GATA3_26560356_Chip-Seq_TH2_Human	0.97409875
97	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96583283
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.96331908
99	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96259758
100	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.93222935

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.15503532
2	MP0008872_abnormal_physiological_respon	2.80868401
3	MP0008877_abnormal_DNA_methylation	2.45475022
4	MP0000569_abnormal_digit_pigmentation	2.38648488
5	MP0006072_abnormal_retinal_apoptosis	2.31827068
6	MP0003646_muscle_fatigue	2.31717109
7	MP0002876_abnormal_thyroid_physiology	2.31017441
8	MP0002837_dystrophic_cardiac_calcinosis	2.25103597
9	MP0001986_abnormal_taste_sensitivity	2.22376843
10	MP0005551_abnormal_eye_electrophysiolog	2.20999230
11	MP0002102_abnormal_ear_morphology	2.18542098
12	MP0001968_abnormal_touch/_nociception	2.16303924
13	MP0006292_abnormal_olfactory_placode	2.13533642
14	MP0002736_abnormal_nociception_after	2.09534533
15	MP0008875_abnormal_xenobiotic_pharmacok	2.05164905
16	MP0002653_abnormal_ependyma_morphology	1.98396434
17	MP0001984_abnormal_olfaction	1.97546902
18	MP0009046_muscle_twitch	1.94942970
19	MP0005220_abnormal_exocrine_pancreas	1.93957565
20	MP0004142_abnormal_muscle_tone	1.92319255
21	MP0001529_abnormal_vocalization	1.88984112
22	MP0004147_increased_porphyrin_level	1.88748705
23	MP0005084_abnormal_gallbladder_morpholo	1.73462993
24	MP0003011_delayed_dark_adaptation	1.68041069
25	MP0003880_abnormal_central_pattern	1.59378252
26	MP0009745_abnormal_behavioral_response	1.58937262
27	MP0002272_abnormal_nervous_system	1.56840611
28	MP0001486_abnormal_startle_reflex	1.55639624
29	MP0005253_abnormal_eye_physiology	1.55604604
30	MP0000427_abnormal_hair_cycle	1.55090309
31	MP0003136_yellow_coat_color	1.51237010
32	MP0002160_abnormal_reproductive_system	1.50698515
33	MP0005646_abnormal_pituitary_gland	1.50626843
34	MP0000015_abnormal_ear_pigmentation	1.49114024
35	MP0003119_abnormal_digestive_system	1.48072589
36	MP0005174_abnormal_tail_pigmentation	1.44466722
37	MP0004133_heterotaxia	1.44281587
38	MP0002928_abnormal_bile_duct	1.43014064
39	MP0004742_abnormal_vestibular_system	1.42391572
40	MP0002095_abnormal_skin_pigmentation	1.40323980
41	MP0006276_abnormal_autonomic_nervous	1.39678510
42	MP0001501_abnormal_sleep_pattern	1.37509202
43	MP0000631_abnormal_neuroendocrine_gland	1.36262620
44	MP0000538_abnormal_urinary_bladder	1.33744417
45	MP0004924_abnormal_behavior	1.33064944
46	MP0005386_behavior/neurological_phenoty	1.33064944
47	MP0005389_reproductive_system_phenotype	1.31855805
48	MP0001919_abnormal_reproductive_system	1.28343581
49	MP0002638_abnormal_pupillary_reflex	1.27268514
50	MP0002557_abnormal_social/conspecific_i	1.26969935
51	MP0002572_abnormal_emotion/affect_behav	1.26785590
52	MP0003283_abnormal_digestive_organ	1.21244588
53	MP0004130_abnormal_muscle_cell	1.19377658
54	MP0003890_abnormal_embryonic-extraembry	1.18482359
55	MP0003787_abnormal_imprinting	1.18044451
56	MP0002938_white_spotting	1.17555414
57	MP0002067_abnormal_sensory_capabilities	1.16393427
58	MP0001485_abnormal_pinna_reflex	1.13094332
59	MP0002735_abnormal_chemical_nociception	1.12019307
60	MP0002163_abnormal_gland_morphology	1.11718440
61	MP0002064_seizures	1.11495195
62	MP0002234_abnormal_pharynx_morphology	1.10865449
63	MP0002693_abnormal_pancreas_physiology	1.09494353
64	MP0005645_abnormal_hypothalamus_physiol	1.07831662
65	MP0001905_abnormal_dopamine_level	1.07499537
66	MP0000372_irregular_coat_pigmentation	1.06756026
67	MP0002063_abnormal_learning/memory/cond	1.06654324
68	MP0003868_abnormal_feces_composition	1.06622318
69	MP0004043_abnormal_pH_regulation	1.05782274
70	MP0001664_abnormal_digestion	1.01585259
71	MP0005499_abnormal_olfactory_system	1.01582248
72	MP0005394_taste/olfaction_phenotype	1.01582248
73	MP0004885_abnormal_endolymph	1.00313858
74	MP0002751_abnormal_autonomic_nervous	0.99482662
75	MP0002277_abnormal_respiratory_mucosa	0.99161118
76	MP0004145_abnormal_muscle_electrophysio	0.99066788
77	MP0001502_abnormal_circadian_rhythm	0.98835685
78	MP0001970_abnormal_pain_threshold	0.98472806
79	MP0001293_anophthalmia	0.98221184
80	MP0005423_abnormal_somatic_nervous	0.98052113
81	MP0003638_abnormal_response/metabolism_	0.96555378
82	MP0005195_abnormal_posterior_eye	0.95965357
83	MP0002734_abnormal_mechanical_nocicepti	0.94573219
84	MP0000026_abnormal_inner_ear	0.91931116
85	MP0005379_endocrine/exocrine_gland_phen	0.91530652
86	MP0000470_abnormal_stomach_morphology	0.91321309
87	MP0010386_abnormal_urinary_bladder	0.90847189
88	MP0008995_early_reproductive_senescence	0.90822344
89	MP0010329_abnormal_lipoprotein_level	0.87082896
90	MP0002733_abnormal_thermal_nociception	0.87055215
91	MP0001944_abnormal_pancreas_morphology	0.86586767
92	MP0005448_abnormal_energy_balance	0.85289617
93	MP0003878_abnormal_ear_physiology	0.84086367
94	MP0005377_hearing/vestibular/ear_phenot	0.84086367
95	MP0001663_abnormal_digestive_system	0.82527506
96	MP0003866_abnormal_defecation	0.82493625
97	MP0009379_abnormal_foot_pigmentation	0.81551977
98	MP0002752_abnormal_somatic_nervous	0.80524374
99	MP0005075_abnormal_melanosome_morpholog	0.80111890
100	MP0003937_abnormal_limbs/digits/tail_de	0.78433211

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.73060657
2	Pancreatic fibrosis (HP:0100732)	4.35496209
3	Pancreatic cysts (HP:0001737)	4.31304210
4	True hermaphroditism (HP:0010459)	3.80029890
5	Molar tooth sign on MRI (HP:0002419)	3.51504002
6	Abnormality of midbrain morphology (HP:0002418)	3.51504002
7	Congenital stationary night blindness (HP:0007642)	3.41129854
8	Nephronophthisis (HP:0000090)	3.32376368
9	Pendular nystagmus (HP:0012043)	3.31478630
10	Abnormality of alanine metabolism (HP:0010916)	3.29768946
11	Hyperalaninemia (HP:0003348)	3.29768946
12	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.29768946
13	Attenuation of retinal blood vessels (HP:0007843)	3.22205471
14	Birth length less than 3rd percentile (HP:0003561)	3.18974495
15	Hyperventilation (HP:0002883)	2.95056739
16	Abnormality of the renal cortex (HP:0011035)	2.93302427
17	Abolished electroretinogram (ERG) (HP:0000550)	2.83937499
18	Cerebellar dysplasia (HP:0007033)	2.83088952
19	Abnormality of the renal medulla (HP:0100957)	2.76770390
20	Inability to walk (HP:0002540)	2.75215990
21	Lissencephaly (HP:0001339)	2.73919621
22	Absent/shortened dynein arms (HP:0200106)	2.72454070
23	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.72454070
24	Chronic hepatic failure (HP:0100626)	2.72008654
25	Chorioretinal atrophy (HP:0000533)	2.69795625
26	Keratoconus (HP:0000563)	2.59642431
27	Increased corneal curvature (HP:0100692)	2.59642431
28	Anencephaly (HP:0002323)	2.58803402
29	Retinal dysplasia (HP:0007973)	2.54955802
30	Medial flaring of the eyebrow (HP:0010747)	2.50467383
31	Pachygyria (HP:0001302)	2.49078864
32	Global brain atrophy (HP:0002283)	2.47848665
33	Progressive inability to walk (HP:0002505)	2.46112734
34	Metaphyseal dysplasia (HP:0100255)	2.42501825
35	Renal cortical cysts (HP:0000803)	2.41611451
36	Methylmalonic acidemia (HP:0002912)	2.41037666
37	Cystic liver disease (HP:0006706)	2.40563456
38	Sclerocornea (HP:0000647)	2.38085316
39	Tubular atrophy (HP:0000092)	2.36662011
40	Disproportionate short-trunk short stature (HP:0003521)	2.36434498
41	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.30333488
42	Hyperglycinemia (HP:0002154)	2.29869441
43	Patellar aplasia (HP:0006443)	2.28648700
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.25582764
45	Abnormal respiratory epithelium morphology (HP:0012253)	2.23551259
46	Abnormal respiratory motile cilium morphology (HP:0005938)	2.23551259
47	Abnormal ciliary motility (HP:0012262)	2.22577894
48	Congenital, generalized hypertrichosis (HP:0004540)	2.21305865
49	Acute necrotizing encephalopathy (HP:0006965)	2.20605953
50	Bile duct proliferation (HP:0001408)	2.18420169
51	Abnormal biliary tract physiology (HP:0012439)	2.18420169
52	Optic disc pallor (HP:0000543)	2.15162278
53	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.15085321
54	Abnormality of macular pigmentation (HP:0008002)	2.14424897
55	Aplasia/Hypoplasia of the patella (HP:0006498)	2.12622103
56	Large for gestational age (HP:0001520)	2.12515728
57	Acute encephalopathy (HP:0006846)	2.12397195
58	Broad-based gait (HP:0002136)	2.11800138
59	Mitochondrial inheritance (HP:0001427)	2.10267967
60	Abnormality of the labia minora (HP:0012880)	2.08208831
61	Optic nerve hypoplasia (HP:0000609)	2.06276204
62	Abnormal rod and cone electroretinograms (HP:0008323)	2.03248959
63	Tachypnea (HP:0002789)	2.02768661
64	Abnormal respiratory motile cilium physiology (HP:0012261)	2.01426979
65	Hypothermia (HP:0002045)	2.00672344
66	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.99421833
67	Furrowed tongue (HP:0000221)	1.99012257
68	Progressive macrocephaly (HP:0004481)	1.98990651
69	Short tibia (HP:0005736)	1.98954571
70	Abnormal drinking behavior (HP:0030082)	1.97097018
71	Polydipsia (HP:0001959)	1.97097018
72	Ketosis (HP:0001946)	1.96066061
73	Male pseudohermaphroditism (HP:0000037)	1.95812863
74	Postaxial foot polydactyly (HP:0001830)	1.95172048
75	Abnormality of the pons (HP:0007361)	1.93926860
76	Hepatic necrosis (HP:0002605)	1.91729067
77	Abnormal number of erythroid precursors (HP:0012131)	1.91501149
78	Ketoacidosis (HP:0001993)	1.89898635
79	Decreased central vision (HP:0007663)	1.89691189
80	Increased CSF lactate (HP:0002490)	1.89581226
81	Rib fusion (HP:0000902)	1.88856627
82	Bilateral microphthalmos (HP:0007633)	1.87338618
83	Hypoplasia of the pons (HP:0012110)	1.86754203
84	Clumsiness (HP:0002312)	1.84156645
85	Occipital encephalocele (HP:0002085)	1.83097661
86	Rectal prolapse (HP:0002035)	1.82279457
87	Progressive cerebellar ataxia (HP:0002073)	1.81358377
88	Small hand (HP:0200055)	1.80929721
89	Genital tract atresia (HP:0001827)	1.80365089
90	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.80311906
91	Methylmalonic aciduria (HP:0012120)	1.80256574
92	Prominent supraorbital ridges (HP:0000336)	1.79217876
93	Hepatocellular necrosis (HP:0001404)	1.77691726
94	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.77195648
95	Abnormal mitochondria in muscle tissue (HP:0008316)	1.77152397
96	Congenital hepatic fibrosis (HP:0002612)	1.77099294
97	Gait imbalance (HP:0002141)	1.76991864
98	Polyuria (HP:0000103)	1.76974936
99	Concave nail (HP:0001598)	1.76233989
100	Fair hair (HP:0002286)	1.75524231

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	5.35600089
2	FRK	5.12489079
3	ZAK	3.38419369
4	TAOK3	3.36864856
5	TLK1	3.26145832
6	ADRBK2	2.60638265
7	BMPR1B	2.50411284
8	WNK3	2.40676939
9	PINK1	2.04030192
10	WNK4	2.02729647
11	GRK1	1.91878865
12	TXK	1.86290744
13	OXSR1	1.67672450
14	ACVR1B	1.61493006
15	MAP4K2	1.61140702
16	MAPK13	1.47602007
17	CASK	1.47484949
18	STK39	1.44530131
19	NUAK1	1.39063892
20	RPS6KA5	1.27245525
21	PNCK	1.26424173
22	MARK1	1.23588709
23	MAP3K4	1.21971717
24	DAPK2	1.20114346
25	ADRBK1	1.17174379
26	MKNK2	1.15915828
27	PIK3CA	1.11712550
28	CAMKK2	1.11209651
29	VRK1	1.10488516
30	STK11	1.10065986
31	NME1	1.02555239
32	MAPK15	0.93103877
33	TGFBR1	0.92951632
34	MAP2K7	0.88179265
35	CDK8	0.84083020
36	VRK2	0.83819930
37	PAK3	0.83663985
38	MKNK1	0.83608774
39	GRK7	0.78688104
40	DYRK2	0.75881221
41	IKBKB	0.75296040
42	PRKCE	0.74079081
43	TEC	0.73856765
44	PHKG1	0.72609225
45	PHKG2	0.72609225
46	CHUK	0.72425072
47	PKN1	0.68590169
48	PRKCG	0.66620937
49	KIT	0.64816769
50	MAPKAPK3	0.63334340
51	OBSCN	0.63181086
52	STK38L	0.61794929
53	FGFR2	0.60090551
54	PRKCZ	0.59631687
55	BRSK2	0.58535328
56	MAP4K1	0.58351240
57	MAPKAPK5	0.58248309
58	MAP3K11	0.56691334
59	EPHA3	0.56539822
60	STK16	0.55718452
61	RPS6KA6	0.55447080
62	BCKDK	0.55244242
63	TIE1	0.54967132
64	NTRK3	0.53870042
65	PRKCQ	0.51997046
66	ITK	0.51691698
67	PLK3	0.51578279
68	PLK2	0.50826984
69	SYK	0.50599162
70	CAMK2A	0.50396483
71	CSNK1G2	0.48841603
72	PTK2B	0.47853955
73	PRKACA	0.46245209
74	MUSK	0.45358658
75	CSNK1G3	0.44703712
76	NEK2	0.44351759
77	IRAK4	0.44096353
78	PDK2	0.43141281
79	LYN	0.43024187
80	CSNK1G1	0.42034868
81	CSNK1A1L	0.41168952
82	PRKG1	0.40992504
83	CSNK1A1	0.39050095
84	ABL2	0.38333847
85	WEE1	0.37270067
86	CDC7	0.37149046
87	SIK2	0.36998666
88	PRKCA	0.36925546
89	CAMK1	0.36716081
90	FES	0.36441393
91	CDK3	0.36105260
92	AKT3	0.35752812
93	MAP3K7	0.35626381
94	ABL1	0.35316471
95	CSNK1D	0.35064911
96	ATR	0.33931905
97	LCK	0.32433203
98	TNIK	0.32373626
99	PLK1	0.32217996
100	RPS6KA2	0.31525845

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.58392169
2	Caffeine metabolism_Homo sapiens_hsa00232	2.97756375
3	Butanoate metabolism_Homo sapiens_hsa00650	2.96780819
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.92932414
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.79555399
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.77074273
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.73350679
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.62578256
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.60691642
10	Phototransduction_Homo sapiens_hsa04744	2.31399410
11	Tryptophan metabolism_Homo sapiens_hsa00380	2.07433732
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.07069554
13	Parkinsons disease_Homo sapiens_hsa05012	2.03981329
14	Ether lipid metabolism_Homo sapiens_hsa00565	2.03165068
15	RNA polymerase_Homo sapiens_hsa03020	1.95398166
16	Homologous recombination_Homo sapiens_hsa03440	1.86565068
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.75073092
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.73128542
19	Nicotine addiction_Homo sapiens_hsa05033	1.71552855
20	Protein export_Homo sapiens_hsa03060	1.69510711
21	Basal transcription factors_Homo sapiens_hsa03022	1.68250247
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64717848
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.62888205
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.62830347
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.53963027
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.42298131
27	Taste transduction_Homo sapiens_hsa04742	1.37650110
28	Huntingtons disease_Homo sapiens_hsa05016	1.32548802
29	One carbon pool by folate_Homo sapiens_hsa00670	1.30888395
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24333961
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.21968703
32	Olfactory transduction_Homo sapiens_hsa04740	1.19261383
33	Alzheimers disease_Homo sapiens_hsa05010	1.18947639
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.14970202
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.13161853
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.10885326
37	Asthma_Homo sapiens_hsa05310	1.09942415
38	Ribosome_Homo sapiens_hsa03010	1.06830063
39	Peroxisome_Homo sapiens_hsa04146	1.06552709
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.00008959
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.99900814
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98666901
43	Insulin secretion_Homo sapiens_hsa04911	0.98393400
44	Retinol metabolism_Homo sapiens_hsa00830	0.95350220
45	RNA degradation_Homo sapiens_hsa03018	0.93961152
46	Morphine addiction_Homo sapiens_hsa05032	0.93116895
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.89606304
48	Primary immunodeficiency_Homo sapiens_hsa05340	0.87227003
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.86100795
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.83087490
51	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.81907460
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81799891
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81469478
54	Serotonergic synapse_Homo sapiens_hsa04726	0.79947487
55	ABC transporters_Homo sapiens_hsa02010	0.78332387
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.77409260
57	GABAergic synapse_Homo sapiens_hsa04727	0.74476528
58	Propanoate metabolism_Homo sapiens_hsa00640	0.73195788
59	Graft-versus-host disease_Homo sapiens_hsa05332	0.72838308
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.71831634
61	Purine metabolism_Homo sapiens_hsa00230	0.67868782
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63129741
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.62615063
64	Metabolic pathways_Homo sapiens_hsa01100	0.62101832
65	Type I diabetes mellitus_Homo sapiens_hsa04940	0.60855123
66	Regulation of autophagy_Homo sapiens_hsa04140	0.60443990
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.58565593
68	Sulfur metabolism_Homo sapiens_hsa00920	0.58271792
69	Nucleotide excision repair_Homo sapiens_hsa03420	0.58007586
70	Circadian entrainment_Homo sapiens_hsa04713	0.57101215
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.55367534
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.55250602
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54409483
74	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.52070469
75	Glutamatergic synapse_Homo sapiens_hsa04724	0.51776473
76	Mineral absorption_Homo sapiens_hsa04978	0.51225147
77	Allograft rejection_Homo sapiens_hsa05330	0.50772376
78	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49717025
79	Histidine metabolism_Homo sapiens_hsa00340	0.49386239
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49157708
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47971285
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.47626927
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46967099
84	Proteasome_Homo sapiens_hsa03050	0.46805647
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.45692420
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45418914
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45290383
88	Pyrimidine metabolism_Homo sapiens_hsa00240	0.43736972
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43598096
90	Sulfur relay system_Homo sapiens_hsa04122	0.39375763
91	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.39283187
92	Cocaine addiction_Homo sapiens_hsa05030	0.38741844
93	Rheumatoid arthritis_Homo sapiens_hsa05323	0.37236009
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.36729307
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.34632422
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.32900270
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.30287365
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.29570064
99	Salivary secretion_Homo sapiens_hsa04970	0.29272391
100	Long-term depression_Homo sapiens_hsa04730	0.28230392

ETF1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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