ETF1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1basic amino acid transport (GO:0015802)7.54344515
2sulfation (GO:0051923)7.05684845
3chemosensory behavior (GO:0007635)7.01533868
4negative regulation of axon extension involved in axon guidance (GO:0048843)6.80988461
5inner cell mass cell proliferation (GO:0001833)6.62683710
6G-protein coupled receptor internalization (GO:0002031)6.46159663
7heart valve formation (GO:0003188)6.43491557
8mRNA polyadenylation (GO:0006378)6.24709407
9Notch signaling involved in heart development (GO:0061314)5.99506059
10cellular response to ATP (GO:0071318)5.89860515
11negative regulation of axon guidance (GO:1902668)5.74916527
12response to pheromone (GO:0019236)5.73732514
13RNA polyadenylation (GO:0043631)5.66466045
14negative regulation of platelet activation (GO:0010544)5.46294409
15post-anal tail morphogenesis (GO:0036342)5.41142918
16primitive streak formation (GO:0090009)5.23694793
17negative regulation of homotypic cell-cell adhesion (GO:0034111)5.20338598
18cardiac right ventricle morphogenesis (GO:0003215)5.06393443
19ventricular trabecula myocardium morphogenesis (GO:0003222)5.04895752
203-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.98735573
21purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.98735573
22cardiac epithelial to mesenchymal transition (GO:0060317)4.93329279
23negative regulation of smooth muscle cell differentiation (GO:0051151)4.78843859
24negative regulation of transcription regulatory region DNA binding (GO:2000678)4.77297403
25histone mRNA metabolic process (GO:0008334)4.77209714
26heart trabecula morphogenesis (GO:0061384)4.21286768
27coronary vasculature morphogenesis (GO:0060977)3.99070137
28negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.94283546
29cell morphogenesis involved in neuron differentiation (GO:0048667)3.88028571
30epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.81850252
31negative regulation of digestive system process (GO:0060457)3.80816455
32dopamine transport (GO:0015872)3.78196542
33regulation of vasculogenesis (GO:2001212)3.72109678
34retinal cone cell development (GO:0046549)3.67183287
35forebrain neuron development (GO:0021884)3.64721995
36regulation of metalloenzyme activity (GO:0048552)3.62362956
37cell surface receptor signaling pathway involved in heart development (GO:0061311)3.61005942
38cardiac left ventricle morphogenesis (GO:0003214)3.60031679
39amyloid precursor protein catabolic process (GO:0042987)3.58800851
40regulation of axon extension involved in axon guidance (GO:0048841)3.58173439
41estrogen biosynthetic process (GO:0006703)3.57604943
42nonmotile primary cilium assembly (GO:0035058)3.53755416
43vagina development (GO:0060068)3.41460822
44negative regulation by host of viral transcription (GO:0043922)3.40485578
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.32757260
46ATP synthesis coupled proton transport (GO:0015986)3.32757260
47positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.31548531
48negative regulation of striated muscle cell apoptotic process (GO:0010664)3.30413111
49positive regulation of prostaglandin secretion (GO:0032308)3.28730854
50regulation of axon guidance (GO:1902667)3.27516896
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.25682317
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.25682317
53receptor guanylyl cyclase signaling pathway (GO:0007168)3.24707868
54uterus development (GO:0060065)3.23128210
55transmission of nerve impulse (GO:0019226)3.22019790
56regulation of platelet aggregation (GO:0090330)3.20609417
57rRNA methylation (GO:0031167)3.20071826
58positive regulation of gastrulation (GO:2000543)3.20057230
59negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19756516
60endocardial cushion morphogenesis (GO:0003203)3.19094388
61regulation of cGMP metabolic process (GO:0030823)3.18268920
62positive regulation of fatty acid transport (GO:2000193)3.17994913
63aorta morphogenesis (GO:0035909)3.16029933
64iron ion import (GO:0097286)3.15271678
65positive regulation of protein kinase C signaling (GO:0090037)3.14794562
66negative regulation of mast cell activation (GO:0033004)3.12648559
67response to gravity (GO:0009629)3.12382287
68regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.12050791
69negative regulation of axon extension (GO:0030517)3.06825384
70regulation of prostaglandin secretion (GO:0032306)3.01979429
71positive regulation of cGMP metabolic process (GO:0030825)3.01868409
72intracellular pH reduction (GO:0051452)2.99721291
73regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)2.99016876
74positive regulation of chemokine biosynthetic process (GO:0045080)2.98227655
75regulation of integrin-mediated signaling pathway (GO:2001044)2.98075280
76embryonic axis specification (GO:0000578)2.97898820
77cGMP biosynthetic process (GO:0006182)2.97478885
78trabecula morphogenesis (GO:0061383)2.97206845
79ventricular septum morphogenesis (GO:0060412)2.95901787
80regulation of cell maturation (GO:1903429)2.93255421
81establishment of tissue polarity (GO:0007164)2.93060402
82establishment of planar polarity (GO:0001736)2.93060402
83positive regulation of T-helper 1 type immune response (GO:0002827)2.87582921
84regulation of thymocyte apoptotic process (GO:0070243)2.86132443
85post-embryonic morphogenesis (GO:0009886)2.85861747
86type B pancreatic cell development (GO:0003323)2.83609959
87cardiac ventricle morphogenesis (GO:0003208)2.82047511
88heart trabecula formation (GO:0060347)2.81532529
89regulation of mitochondrial translation (GO:0070129)2.81380137
90somitogenesis (GO:0001756)2.79370070
91ventricular cardiac muscle cell development (GO:0055015)2.79300021
92positive regulation of macrophage cytokine production (GO:0060907)2.78084198
93heart valve morphogenesis (GO:0003179)2.77900624
94maternal behavior (GO:0042711)2.77789382
95ganglion development (GO:0061548)2.76713679
96rRNA modification (GO:0000154)2.76195191
97regulation of homotypic cell-cell adhesion (GO:0034110)2.75496379
98convergent extension (GO:0060026)2.73781993
99regulation of transcription regulatory region DNA binding (GO:2000677)2.72217790
100histone mRNA catabolic process (GO:0071044)10.0918872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.57326219
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.27413902
3VDR_22108803_ChIP-Seq_LS180_Human3.56268156
4GBX2_23144817_ChIP-Seq_PC3_Human3.20134420
5ZNF274_21170338_ChIP-Seq_K562_Hela2.94437050
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.78790682
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78779793
8TAF15_26573619_Chip-Seq_HEK293_Human2.77128662
9EZH2_22144423_ChIP-Seq_EOC_Human2.34756876
10FOXA1_21572438_ChIP-Seq_LNCaP_Human2.06613701
11BCAT_22108803_ChIP-Seq_LS180_Human2.05994231
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03763528
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.03638681
14STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.00460828
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.98034190
16IGF1R_20145208_ChIP-Seq_DFB_Human1.95514305
17AR_21572438_ChIP-Seq_LNCaP_Human1.93390673
18ER_23166858_ChIP-Seq_MCF-7_Human1.92887597
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.81756543
20TP53_22573176_ChIP-Seq_HFKS_Human1.80220493
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.72359270
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67699321
23RXR_22108803_ChIP-Seq_LS180_Human1.67645664
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.65674125
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65499116
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57241765
27NANOG_20526341_ChIP-Seq_ESCs_Human1.55105415
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54475998
29TP53_16413492_ChIP-PET_HCT116_Human1.50454785
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47652950
31RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45464543
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45436877
33P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.44684494
34SMAD3_21741376_ChIP-Seq_HESCs_Human1.44651078
35HOXB7_26014856_ChIP-Seq_BT474_Human1.44630386
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44505219
37FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42855401
38FOXA1_25329375_ChIP-Seq_VCAP_Human1.42855401
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41443379
40ERG_20517297_ChIP-Seq_VCAP_Human1.40422270
41AR_20517297_ChIP-Seq_VCAP_Human1.39003894
42ERA_21632823_ChIP-Seq_H3396_Human1.36495139
43GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36335689
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.35613220
45PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.33063953
46ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33016271
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32576420
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32576420
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.32175932
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31637597
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31479836
52SPI1_20517297_ChIP-Seq_HL60_Human1.31420905
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.25976031
54MYC_18940864_ChIP-ChIP_HL60_Human1.24116186
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23288599
56GATA3_26560356_Chip-Seq_TH2_Human1.22339649
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.20997538
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18739012
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17924515
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17819595
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17536358
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17185595
63CJUN_26792858_Chip-Seq_BT549_Human1.16640082
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15694404
65CBP_21632823_ChIP-Seq_H3396_Human1.15099762
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13404589
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.13333452
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13308384
69EWS_26573619_Chip-Seq_HEK293_Human1.13072011
70STAT3_23295773_ChIP-Seq_U87_Human1.13020206
71GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.12809180
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12645890
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11611788
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.11487284
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.11162562
76TAF2_19829295_ChIP-Seq_ESCs_Human1.09847610
77FOXH1_21741376_ChIP-Seq_ESCs_Human1.09713359
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09429185
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08396373
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07641570
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07211573
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07163710
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07158340
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06777045
85P300_19829295_ChIP-Seq_ESCs_Human1.06369399
86SOX2_21211035_ChIP-Seq_LN229_Human1.05984140
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05835472
88RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04821359
89JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04564329
90AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04025321
91TBL1_22424771_ChIP-Seq_293T_Human1.03723871
92NANOG_19829295_ChIP-Seq_ESCs_Human1.01609558
93SOX2_19829295_ChIP-Seq_ESCs_Human1.01609558
94YY1_22570637_ChIP-Seq_MALME-3M_Human1.00886224
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98783604
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98333458
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.97713810
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97091243
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97038504
100CBX2_27304074_Chip-Seq_ESCs_Mouse0.96843387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry7.63597901
2MP0004147_increased_porphyrin_level5.13563285
3MP0003011_delayed_dark_adaptation4.33961327
4MP0003252_abnormal_bile_duct3.09548227
5MP0006054_spinal_hemorrhage3.00646380
6MP0004145_abnormal_muscle_electrophysio2.93895133
7MP0003279_aneurysm2.76047628
8MP0006072_abnormal_retinal_apoptosis2.67349543
9MP0009384_cardiac_valve_regurgitation2.58421335
10MP0002938_white_spotting2.31591005
11MP0008058_abnormal_DNA_repair2.19199585
12MP0002653_abnormal_ependyma_morphology2.16627056
13MP0002089_abnormal_postnatal_growth/wei2.14967068
14MP0003195_calcinosis2.09565093
15MP0009046_muscle_twitch1.97515179
16MP0003936_abnormal_reproductive_system1.87434130
17MP0005253_abnormal_eye_physiology1.85950932
18MP0005551_abnormal_eye_electrophysiolog1.84089127
19MP0008961_abnormal_basal_metabolism1.78214892
20MP0009053_abnormal_anal_canal1.68961869
21MP0000013_abnormal_adipose_tissue1.67762819
22MP0001986_abnormal_taste_sensitivity1.66395328
23MP0004043_abnormal_pH_regulation1.65758644
24MP0001529_abnormal_vocalization1.65726409
25MP0003123_paternal_imprinting1.64473492
26MP0001664_abnormal_digestion1.60548448
27MP0004142_abnormal_muscle_tone1.53975543
28MP0005085_abnormal_gallbladder_physiolo1.53813663
29MP0010368_abnormal_lymphatic_system1.51917438
30MP0000427_abnormal_hair_cycle1.50432225
31MP0000538_abnormal_urinary_bladder1.43235855
32MP0000343_altered_response_to1.42056114
33MP0002272_abnormal_nervous_system1.41408979
34MP0006138_congestive_heart_failure1.40262293
35MP0004019_abnormal_vitamin_homeostasis1.38644882
36MP0005084_abnormal_gallbladder_morpholo1.35013001
37MP0009745_abnormal_behavioral_response1.30867193
38MP0002282_abnormal_trachea_morphology1.27594791
39MP0001879_abnormal_lymphatic_vessel1.26515046
40MP0009379_abnormal_foot_pigmentation1.26091257
41MP0005330_cardiomyopathy1.23250532
42MP0004130_abnormal_muscle_cell1.22227780
43MP0008007_abnormal_cellular_replicative1.20802108
44MP0004085_abnormal_heartbeat1.20451886
45MP0005310_abnormal_salivary_gland1.18785140
46MP0008872_abnormal_physiological_respon1.17514762
47MP0008569_lethality_at_weaning1.13468658
48MP0008438_abnormal_cutaneous_collagen1.11837610
49MP0003937_abnormal_limbs/digits/tail_de1.10122416
50MP0008995_early_reproductive_senescence1.09162641
51MP0008875_abnormal_xenobiotic_pharmacok1.06413656
52MP0005595_abnormal_vascular_smooth1.05761551
53MP0002067_abnormal_sensory_capabilities1.04014230
54MP0005332_abnormal_amino_acid1.01358162
55MP0001501_abnormal_sleep_pattern1.01333479
56MP0002009_preneoplasia0.98120279
57MP0000569_abnormal_digit_pigmentation0.97568803
58MP0005266_abnormal_metabolism0.96168367
59MP0004133_heterotaxia0.95643928
60MP0010329_abnormal_lipoprotein_level0.93420433
61MP0002277_abnormal_respiratory_mucosa0.91863722
62MP0005171_absent_coat_pigmentation0.91433751
63MP0004883_abnormal_blood_vessel0.90826386
64MP0008932_abnormal_embryonic_tissue0.90160941
65MP0001853_heart_inflammation0.87694401
66MP0002928_abnormal_bile_duct0.86003121
67MP0002160_abnormal_reproductive_system0.84191450
68MP0000467_abnormal_esophagus_morphology0.84011404
69MP0003283_abnormal_digestive_organ0.80406103
70MP0005409_darkened_coat_color0.80143200
71MP0000003_abnormal_adipose_tissue0.79239506
72MP0005167_abnormal_blood-brain_barrier0.79183550
73MP0000230_abnormal_systemic_arterial0.78476137
74MP0003091_abnormal_cell_migration0.77623382
75MP0003950_abnormal_plasma_membrane0.77080454
76MP0003942_abnormal_urinary_system0.76921787
77MP0001119_abnormal_female_reproductive0.76429207
78MP0005376_homeostasis/metabolism_phenot0.74618624
79MP0008775_abnormal_heart_ventricle0.73638166
80MP0005164_abnormal_response_to0.73369396
81MP0002557_abnormal_social/conspecific_i0.71607188
82MP0005620_abnormal_muscle_contractility0.69279210
83MP0003191_abnormal_cellular_cholesterol0.68738799
84MP0005645_abnormal_hypothalamus_physiol0.68444545
85MP0008057_abnormal_DNA_replication0.68333830
86MP0005360_urolithiasis0.67674182
87MP0005584_abnormal_enzyme/coenzyme_acti0.67241043
88MP0005391_vision/eye_phenotype0.66865449
89MP0002837_dystrophic_cardiac_calcinosis0.66370653
90MP0002064_seizures0.65051840
91MP0002751_abnormal_autonomic_nervous0.63553504
92MP0000762_abnormal_tongue_morphology0.63445756
93MP0002752_abnormal_somatic_nervous0.60624910
94MP0006276_abnormal_autonomic_nervous0.59949975
95MP0002210_abnormal_sex_determination0.59076386
96MP0003638_abnormal_response/metabolism_0.56774820
97MP0002932_abnormal_joint_morphology0.55361884
98MP0005389_reproductive_system_phenotype0.54887853
99MP0002736_abnormal_nociception_after0.51316015
100MP0006035_abnormal_mitochondrial_morpho0.50619342

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)9.45954826
2Spastic paraparesis (HP:0002313)8.85741523
3Chromsome breakage (HP:0040012)8.27897397
4Congenital stationary night blindness (HP:0007642)5.65888973
5Paraparesis (HP:0002385)5.16166259
6Posterior subcapsular cataract (HP:0007787)5.05491320
7Medulloblastoma (HP:0002885)4.55217140
8Aplasia/Hypoplasia of the uvula (HP:0010293)4.27604138
9Progressive inability to walk (HP:0002505)3.87719501
10Genetic anticipation (HP:0003743)3.72478602
11Nephroblastoma (Wilms tumor) (HP:0002667)3.57762992
12Meckel diverticulum (HP:0002245)3.54417671
13Abnormal biliary tract physiology (HP:0012439)3.48265424
14Bile duct proliferation (HP:0001408)3.48265424
15Embryonal renal neoplasm (HP:0011794)3.42185652
16Abnormality of the ileum (HP:0001549)3.36180911
17Abnormality of the preputium (HP:0100587)3.29729003
18Clubbing of toes (HP:0100760)3.28831239
19Emotional lability (HP:0000712)3.23066752
20Abnormality of chromosome stability (HP:0003220)2.92438098
21Pancytopenia (HP:0001876)2.85457693
22Neuroblastic tumors (HP:0004376)2.82172803
23Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.82172803
24Neuroblastoma (HP:0003006)2.82172803
25Primitive neuroectodermal tumor (HP:0030065)2.82172803
26Subcapsular cataract (HP:0000523)2.80582467
27Progressive cerebellar ataxia (HP:0002073)2.79880173
28Short middle phalanx of the 5th finger (HP:0004220)2.79159027
29Hemiparesis (HP:0001269)2.69819172
30Reticulocytopenia (HP:0001896)2.66377908
31Molar tooth sign on MRI (HP:0002419)2.66072735
32Abnormality of midbrain morphology (HP:0002418)2.66072735
33Testicular atrophy (HP:0000029)2.63934052
34Birth length less than 3rd percentile (HP:0003561)2.62444137
35Inability to walk (HP:0002540)2.61419080
36Increased number of teeth (HP:0011069)2.56249903
37Scotoma (HP:0000575)2.44328554
38Abnormality of the carotid arteries (HP:0005344)2.43455440
39Abnormality of alanine metabolism (HP:0010916)2.32511029
40Hyperalaninemia (HP:0003348)2.32511029
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32511029
42Muscle hypertrophy of the lower extremities (HP:0008968)2.30494235
43Pili torti (HP:0003777)2.29854688
44Horizontal nystagmus (HP:0000666)2.26965708
45Short thumb (HP:0009778)2.17294715
46Abnormal number of erythroid precursors (HP:0012131)2.14973140
47Small intestinal stenosis (HP:0012848)2.11587720
48Duodenal stenosis (HP:0100867)2.11587720
49Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10237179
50Concave nail (HP:0001598)2.08602379
51Embryonal neoplasm (HP:0002898)2.05984735
52Attenuation of retinal blood vessels (HP:0007843)2.04631976
53Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02398358
54Duplicated collecting system (HP:0000081)2.02156130
55Astigmatism (HP:0000483)2.02022207
56Aplastic anemia (HP:0001915)10.3830487
57Arthropathy (HP:0003040)1.99831279
58Triphalangeal thumb (HP:0001199)1.99438299
59Pendular nystagmus (HP:0012043)1.97297876
60Secondary amenorrhea (HP:0000869)1.95448249
61Azoospermia (HP:0000027)1.95426502
62Hyperglycinuria (HP:0003108)1.94869323
63Abnormality of the duodenum (HP:0002246)1.93826376
64Sex reversal (HP:0012245)1.91299123
65Abnormal sex determination (HP:0012244)1.91299123
66Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.90347538
67Mesomelia (HP:0003027)1.89419546
68Short 5th finger (HP:0009237)1.86835092
69Vacuolated lymphocytes (HP:0001922)1.84796599
70Abnormal gallbladder physiology (HP:0012438)1.84486163
71Cholecystitis (HP:0001082)1.84486163
72Breast hypoplasia (HP:0003187)1.83808310
73Abnormality of the renal collecting system (HP:0004742)1.80700456
74Abnormality of abdominal situs (HP:0011620)1.79446550
75Abdominal situs inversus (HP:0003363)1.79446550
76Macular degeneration (HP:0000608)1.79429063
77Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.78052707
78Brushfield spots (HP:0001088)1.76696207
79Nervous tissue neoplasm (HP:0030060)1.75971196
80Neuroectodermal neoplasm (HP:0030061)1.75971196
81Neuroepithelial neoplasm (HP:0030063)1.75971196
82Type II lissencephaly (HP:0007260)1.75906926
83Myotonia (HP:0002486)1.75814600
84Confusion (HP:0001289)1.74754386
85Hypoplastic labia majora (HP:0000059)1.73282043
86Abnormality of cells of the erythroid lineage (HP:0012130)1.73069304
87Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.71478268
88Arteriovenous malformation (HP:0100026)1.70692086
89Abnormal drinking behavior (HP:0030082)1.69078642
90Polydipsia (HP:0001959)1.69078642
91True hermaphroditism (HP:0010459)1.67422182
92Congenital, generalized hypertrichosis (HP:0004540)1.66518035
93Polyuria (HP:0000103)1.64038998
94Female pseudohermaphroditism (HP:0010458)1.62349234
95Spastic tetraparesis (HP:0001285)1.61336139
96Neonatal respiratory distress (HP:0002643)1.61135399
97Abnormal hair laboratory examination (HP:0003328)1.58017363
98Medial flaring of the eyebrow (HP:0010747)1.57635070
99Long nose (HP:0003189)1.56301438
100Renal duplication (HP:0000075)1.56276252

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK17.13246225
2TSSK64.55840001
3NME13.44215463
4EIF2AK12.85613133
5PASK2.61896328
6STK392.57943151
7WNK42.47093768
8DYRK32.45631575
9ADRBK22.41235494
10STK38L2.38557663
11TGFBR12.30363250
12BRSK22.29887379
13CAMKK22.22385909
14MAPK152.21540079
15ACVR1B2.11291868
16MAPKAPK32.07188031
17ERN12.04761314
18BMPR1B1.98764844
19EPHB21.97655292
20MKNK21.75542725
21EIF2AK31.75131588
22BRSK11.63856559
23FRK1.61003711
24WNK31.56386776
25OXSR11.52787514
26WEE11.49694231
27TAOK31.44575064
28STK241.36473992
29MAP3K101.32294877
30MST41.22645235
31ADRBK11.18043493
32ABL21.13693542
33MAP3K91.12645270
34BCKDK1.10110618
35STK31.06805052
36BMX1.02652301
37KIT1.01605448
38MKNK10.98685590
39NEK60.90087228
40GRK50.86351053
41CAMKK10.86305062
42ZAK0.86070145
43VRK20.85803943
44CHUK0.81907006
45IKBKB0.80382797
46TNK20.79709675
47MAP3K40.78792737
48MAPK130.76826493
49KSR10.73375310
50MAP4K20.71029785
51PRKD20.67630781
52NEK20.66939525
53VRK10.63963292
54PRKCI0.62455779
55MAP2K10.60076357
56MAP2K70.59659210
57STK160.55084406
58MUSK0.54263461
59DYRK1A0.52378997
60BMPR20.50303406
61MAP3K20.48865861
62PAK30.45798563
63MAPKAPK50.44232134
64CAMK1D0.43944564
65NEK10.43383774
66TLK10.43010814
67CSNK1G30.41430245
68PLK30.41409971
69SGK30.41079852
70PTK2B0.40202213
71CSNK1A1L0.39464878
72STK110.38888722
73SGK20.34566626
74RPS6KA10.34435839
75GRK70.34382937
76PLK10.32987850
77IRAK30.32513350
78PRKCQ0.31395570
79STK100.31095740
80CSNK1G20.30294179
81RPS6KA50.29552336
82CDK30.27714868
83INSRR0.26153559
84CSNK1D0.26114723
85SGK2230.25510261
86SGK4940.25510261
87MAP2K40.24957480
88PRKCG0.24430880
89PLK20.23524297
90PIK3CA0.23114833
91PINK10.22977579
92PRKD30.20882079
93RPS6KB20.20486428
94CSNK2A20.20402571
95KDR0.20142828
96ARAF0.18788794
97PRKACA0.16597721
98PIK3CG0.15022669
99ERBB20.14283250
100CSNK1G10.13930516

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000617.13963508
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.66283206
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.49260469
4Phototransduction_Homo sapiens_hsa047443.05693319
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.90796224
6Basal transcription factors_Homo sapiens_hsa030222.75903393
7Nitrogen metabolism_Homo sapiens_hsa009102.74638492
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.12131143
9Fanconi anemia pathway_Homo sapiens_hsa034601.89591606
10Ribosome_Homo sapiens_hsa030101.89480719
11Linoleic acid metabolism_Homo sapiens_hsa005911.85708263
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78093745
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.72145326
14Mineral absorption_Homo sapiens_hsa049781.59198112
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.58712182
16Arachidonic acid metabolism_Homo sapiens_hsa005901.58553328
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57281150
18Butanoate metabolism_Homo sapiens_hsa006501.56377631
19Fatty acid degradation_Homo sapiens_hsa000711.54816671
20Fat digestion and absorption_Homo sapiens_hsa049751.46502484
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38850332
22Protein export_Homo sapiens_hsa030601.34157289
23Ether lipid metabolism_Homo sapiens_hsa005651.29619846
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.28694134
25Sulfur relay system_Homo sapiens_hsa041221.25895250
26Propanoate metabolism_Homo sapiens_hsa006401.24195951
27Chemical carcinogenesis_Homo sapiens_hsa052041.23048056
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.20428915
29Oxidative phosphorylation_Homo sapiens_hsa001901.16419972
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14355786
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13163722
32Steroid biosynthesis_Homo sapiens_hsa001001.11158739
33Fatty acid metabolism_Homo sapiens_hsa012121.09697694
34Parkinsons disease_Homo sapiens_hsa050121.08994704
35Glutathione metabolism_Homo sapiens_hsa004801.04431758
36Alzheimers disease_Homo sapiens_hsa050101.03742361
37Cardiac muscle contraction_Homo sapiens_hsa042601.02099706
38Calcium signaling pathway_Homo sapiens_hsa040200.99004042
39Histidine metabolism_Homo sapiens_hsa003400.97714861
40Tight junction_Homo sapiens_hsa045300.95195900
41Morphine addiction_Homo sapiens_hsa050320.93903243
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92435537
43One carbon pool by folate_Homo sapiens_hsa006700.92283230
44ABC transporters_Homo sapiens_hsa020100.91367387
45Tryptophan metabolism_Homo sapiens_hsa003800.86531609
46Taste transduction_Homo sapiens_hsa047420.85244380
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84160048
48PPAR signaling pathway_Homo sapiens_hsa033200.81184684
49Nucleotide excision repair_Homo sapiens_hsa034200.79392494
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79080973
51Salivary secretion_Homo sapiens_hsa049700.74657139
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72918699
53Homologous recombination_Homo sapiens_hsa034400.72508345
54Glutamatergic synapse_Homo sapiens_hsa047240.69770488
55Circadian entrainment_Homo sapiens_hsa047130.69546532
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69196869
57Retinol metabolism_Homo sapiens_hsa008300.68976994
58GABAergic synapse_Homo sapiens_hsa047270.67325422
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66484977
60ECM-receptor interaction_Homo sapiens_hsa045120.65234697
61Basal cell carcinoma_Homo sapiens_hsa052170.64011943
62Olfactory transduction_Homo sapiens_hsa047400.63854158
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59387922
64Cholinergic synapse_Homo sapiens_hsa047250.58956079
65Peroxisome_Homo sapiens_hsa041460.56843269
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56634602
67Legionellosis_Homo sapiens_hsa051340.56122888
68Vitamin digestion and absorption_Homo sapiens_hsa049770.55100596
69Ovarian steroidogenesis_Homo sapiens_hsa049130.54198405
70Selenocompound metabolism_Homo sapiens_hsa004500.53118393
71Long-term depression_Homo sapiens_hsa047300.52849824
72Huntingtons disease_Homo sapiens_hsa050160.52656039
73Oxytocin signaling pathway_Homo sapiens_hsa049210.52550076
74Hedgehog signaling pathway_Homo sapiens_hsa043400.51553240
75Glucagon signaling pathway_Homo sapiens_hsa049220.46867465
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.46309679
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.41046707
78Serotonergic synapse_Homo sapiens_hsa047260.40137390
79Hematopoietic cell lineage_Homo sapiens_hsa046400.36848299
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36543540
81Nicotine addiction_Homo sapiens_hsa050330.35977509
82Dopaminergic synapse_Homo sapiens_hsa047280.35137275
83Renin secretion_Homo sapiens_hsa049240.34859315
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34151273
85MAPK signaling pathway_Homo sapiens_hsa040100.33159539
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31756734
87Glycerolipid metabolism_Homo sapiens_hsa005610.31752669
88RNA polymerase_Homo sapiens_hsa030200.31589458
89Caffeine metabolism_Homo sapiens_hsa002320.31320968
90beta-Alanine metabolism_Homo sapiens_hsa004100.30315416
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30277161
92Dorso-ventral axis formation_Homo sapiens_hsa043200.30081000
93Hippo signaling pathway_Homo sapiens_hsa043900.29401925
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28829265
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27480087
96Metabolic pathways_Homo sapiens_hsa011000.27115997
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25642520
98Wnt signaling pathway_Homo sapiens_hsa043100.25559112
99Prion diseases_Homo sapiens_hsa050200.23916266
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23133282

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