ETFA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)5.80298560
2lysine catabolic process (GO:0006554)5.80298560
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.70414104
4L-phenylalanine catabolic process (GO:0006559)5.70414104
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.66529390
6L-phenylalanine metabolic process (GO:0006558)5.66529390
7glyoxylate metabolic process (GO:0046487)5.36463275
8aromatic amino acid family catabolic process (GO:0009074)5.16196708
9fatty acid beta-oxidation (GO:0006635)5.13490005
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.06675250
11amino-acid betaine metabolic process (GO:0006577)4.93920807
12cysteine metabolic process (GO:0006534)4.83366085
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.82139127
14kynurenine metabolic process (GO:0070189)4.81418440
15alpha-linolenic acid metabolic process (GO:0036109)4.79940809
16tricarboxylic acid cycle (GO:0006099)4.74672160
17tryptophan catabolic process (GO:0006569)4.71741316
18indole-containing compound catabolic process (GO:0042436)4.71741316
19indolalkylamine catabolic process (GO:0046218)4.71741316
20regulation of triglyceride catabolic process (GO:0010896)4.71176907
21fatty acid oxidation (GO:0019395)4.71095018
22branched-chain amino acid catabolic process (GO:0009083)4.70797522
23regulation of sequestering of triglyceride (GO:0010889)4.63448223
24lipid oxidation (GO:0034440)4.63409722
25valine metabolic process (GO:0006573)4.62792014
262-oxoglutarate metabolic process (GO:0006103)4.57006105
27fatty acid catabolic process (GO:0009062)4.56435263
28sulfur amino acid catabolic process (GO:0000098)4.55767997
29cellular ketone body metabolic process (GO:0046950)4.52034188
30fatty acid transmembrane transport (GO:1902001)4.48471602
31bile acid biosynthetic process (GO:0006699)4.46374128
32tryptophan metabolic process (GO:0006568)4.46284395
33carnitine metabolic process (GO:0009437)4.44573264
34serine family amino acid catabolic process (GO:0009071)4.42222168
35acetyl-CoA metabolic process (GO:0006084)4.41441784
36short-chain fatty acid metabolic process (GO:0046459)4.35364949
37branched-chain amino acid metabolic process (GO:0009081)4.35080263
38carnitine shuttle (GO:0006853)4.30563651
39aspartate family amino acid catabolic process (GO:0009068)4.29810419
40monocarboxylic acid catabolic process (GO:0072329)4.23588158
41homocysteine metabolic process (GO:0050667)4.20911583
42urea metabolic process (GO:0019627)4.17818422
43urea cycle (GO:0000050)4.17818422
44proline biosynthetic process (GO:0006561)4.10118871
45alpha-amino acid catabolic process (GO:1901606)4.07939507
46complement activation, alternative pathway (GO:0006957)4.03751474
47positive regulation of fatty acid beta-oxidation (GO:0032000)4.02599307
48biotin metabolic process (GO:0006768)4.00548249
49ethanol oxidation (GO:0006069)3.99957822
50acylglycerol homeostasis (GO:0055090)3.91512318
51triglyceride homeostasis (GO:0070328)3.91512318
52negative regulation of fibrinolysis (GO:0051918)3.90438786
53nitrogen cycle metabolic process (GO:0071941)3.90278992
54positive regulation of fatty acid oxidation (GO:0046321)3.90250303
55negative regulation of fatty acid biosynthetic process (GO:0045717)3.90180322
56cellular amino acid catabolic process (GO:0009063)3.88978311
57NADH metabolic process (GO:0006734)3.88623606
58regulation of fatty acid oxidation (GO:0046320)3.87969421
59protein carboxylation (GO:0018214)3.87906720
60peptidyl-glutamic acid carboxylation (GO:0017187)3.87906720
61organic acid catabolic process (GO:0016054)3.87886427
62carboxylic acid catabolic process (GO:0046395)3.87886427
63ketone body metabolic process (GO:1902224)3.87869249
64high-density lipoprotein particle remodeling (GO:0034375)3.87717981
65proteasome assembly (GO:0043248)3.86803127
66regulation of protein activation cascade (GO:2000257)3.86632229
67aromatic amino acid family metabolic process (GO:0009072)3.84410250
68tricarboxylic acid metabolic process (GO:0072350)3.82338793
69glycine metabolic process (GO:0006544)3.78506270
70bile acid metabolic process (GO:0008206)3.76187805
71oxidative phosphorylation (GO:0006119)3.74283001
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.73630642
73serine family amino acid metabolic process (GO:0009069)3.71476177
74succinate metabolic process (GO:0006105)3.69403762
75regulation of fibrinolysis (GO:0051917)3.69001982
76positive regulation of lipid catabolic process (GO:0050996)3.68362219
77plasma lipoprotein particle clearance (GO:0034381)3.66312050
78regulation of complement activation (GO:0030449)3.64701563
79cellular glucuronidation (GO:0052695)3.58501934
80protein-lipid complex remodeling (GO:0034368)3.57061819
81macromolecular complex remodeling (GO:0034367)3.57061819
82plasma lipoprotein particle remodeling (GO:0034369)3.57061819
83coenzyme catabolic process (GO:0009109)3.48176595
84regulation of cholesterol esterification (GO:0010872)3.46210370
85oxaloacetate metabolic process (GO:0006107)3.45427367
86amino-acid betaine transport (GO:0015838)3.45347325
87carnitine transport (GO:0015879)3.45347325
88tyrosine metabolic process (GO:0006570)3.45036784
89regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.44567332
90carnitine transmembrane transport (GO:1902603)3.44491236
91nucleobase-containing small molecule interconversion (GO:0015949)3.42871512
92reverse cholesterol transport (GO:0043691)3.42074563
93regulation of cholesterol metabolic process (GO:0090181)3.40022039
94serine family amino acid biosynthetic process (GO:0009070)3.38854795
95benzene-containing compound metabolic process (GO:0042537)3.36681998
96cellular modified amino acid catabolic process (GO:0042219)3.35700538
97negative regulation of fatty acid metabolic process (GO:0045922)3.34076046
98regulation of fatty acid beta-oxidation (GO:0031998)3.32631398
99DNA strand elongation involved in DNA replication (GO:0006271)3.31673305
100aldehyde catabolic process (GO:0046185)3.30485000
101phospholipid homeostasis (GO:0055091)3.25940240
102indolalkylamine metabolic process (GO:0006586)3.25342850
103phospholipid efflux (GO:0033700)3.25071078
104negative regulation of sterol transport (GO:0032372)3.24924075
105negative regulation of cholesterol transport (GO:0032375)3.24924075
106small molecule catabolic process (GO:0044282)3.23478565
107DNA strand elongation (GO:0022616)3.22749907
108formation of translation preinitiation complex (GO:0001731)3.19010905
109telomere maintenance via semi-conservative replication (GO:0032201)3.16527912
110ribosome assembly (GO:0042255)3.15436845
111proline metabolic process (GO:0006560)3.14443455
112COPI coating of Golgi vesicle (GO:0048205)3.10492787
113Golgi transport vesicle coating (GO:0048200)3.10492787
114polyketide metabolic process (GO:0030638)3.03094507
115doxorubicin metabolic process (GO:0044598)3.03094507
116daunorubicin metabolic process (GO:0044597)3.03094507
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01169461
118regulation of translational fidelity (GO:0006450)2.97843040
119negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96338132
120ATP synthesis coupled proton transport (GO:0015986)2.95824947
121energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95824947
122tetrahydrofolate metabolic process (GO:0046653)2.92525984
123mitotic chromosome condensation (GO:0007076)2.91079645
124folic acid-containing compound biosynthetic process (GO:0009396)2.90189852
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.85737797
126regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85580137
127aminoglycoside antibiotic metabolic process (GO:0030647)2.85146246
128regulation of cellular amino acid metabolic process (GO:0006521)2.82509898
129maturation of SSU-rRNA (GO:0030490)2.80641091
130protein maturation by protein folding (GO:0022417)2.78036812
131* respiratory electron transport chain (GO:0022904)2.76552152
132purine nucleobase biosynthetic process (GO:0009113)2.72085129
133pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.71492193
134positive regulation of cellular amine metabolic process (GO:0033240)2.71354446
135negative regulation of ligase activity (GO:0051352)2.71058046
136negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71058046
137deoxyribonucleotide biosynthetic process (GO:0009263)2.69535568
138* electron transport chain (GO:0022900)2.69516464
139mitotic metaphase plate congression (GO:0007080)2.67928721
140folic acid-containing compound metabolic process (GO:0006760)2.63810625
141regulation of mitochondrial translation (GO:0070129)2.63655579
142ribosomal small subunit biogenesis (GO:0042274)2.63543891
143pteridine-containing compound biosynthetic process (GO:0042559)2.63469521
144telomere maintenance via recombination (GO:0000722)2.61978831
145very-low-density lipoprotein particle assembly (GO:0034379)2.61458142
146glucuronate metabolic process (GO:0019585)2.59686806
147uronic acid metabolic process (GO:0006063)2.59686806
148blood coagulation, intrinsic pathway (GO:0007597)2.59311435
149CENP-A containing nucleosome assembly (GO:0034080)2.58761219
150ribosomal large subunit biogenesis (GO:0042273)2.58448146
151glutamine family amino acid biosynthetic process (GO:0009084)2.57215023
152deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56579235
153negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.55613088
154protein localization to chromosome, centromeric region (GO:0071459)2.54056583
155amino acid salvage (GO:0043102)2.54028822
156L-methionine salvage (GO:0071267)2.54028822
157L-methionine biosynthetic process (GO:0071265)2.54028822
158AMP metabolic process (GO:0046033)2.53866200
159gluconeogenesis (GO:0006094)2.53489856
160protein neddylation (GO:0045116)2.51055638
161aerobic respiration (GO:0009060)2.50957760
1622-deoxyribonucleotide biosynthetic process (GO:0009265)2.50220832
163deoxyribose phosphate biosynthetic process (GO:0046385)2.50220832
164positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.49428606
165glycoside metabolic process (GO:0016137)2.48566407
166pteridine-containing compound metabolic process (GO:0042558)2.47515173
167nuclear pore organization (GO:0006999)2.47276957
168methionine metabolic process (GO:0006555)2.43846797
169positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.43259161
170epoxygenase P450 pathway (GO:0019373)2.42292096
171alpha-amino acid biosynthetic process (GO:1901607)2.42220711
172monosaccharide biosynthetic process (GO:0046364)2.42086944
173tRNA aminoacylation for protein translation (GO:0006418)2.42069220
174protein localization to kinetochore (GO:0034501)2.42061061
175nucleobase biosynthetic process (GO:0046112)2.41934645
176mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41483276
177folic acid metabolic process (GO:0046655)2.40793664
178L-serine metabolic process (GO:0006563)2.40698132
179positive regulation of ligase activity (GO:0051351)2.40193509
180amino acid activation (GO:0043038)2.38820911
181tRNA aminoacylation (GO:0043039)2.38820911

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.56608642
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.26027731
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.69858117
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.04070861
5E2F7_22180533_ChIP-Seq_HELA_Human5.90620966
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.11817808
7EGR1_23403033_ChIP-Seq_LIVER_Mouse5.00833401
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.23154367
9* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.07854855
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.03928192
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.20615013
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.10543655
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.02078971
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59884424
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54818186
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53602560
17* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.43428825
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.42126511
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42099000
20CLOCK_20551151_ChIP-Seq_293T_Human2.38574102
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34071128
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.30854727
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.15890726
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11840009
25* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.09399231
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02159308
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99863089
28XRN2_22483619_ChIP-Seq_HELA_Human1.91709716
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.81713879
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.78631390
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77323878
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75224409
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74805098
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71679753
35ELK1_19687146_ChIP-ChIP_HELA_Human1.71519289
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.69938294
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69302493
38GABP_19822575_ChIP-Seq_HepG2_Human1.68329833
39FOXP3_21729870_ChIP-Seq_TREG_Human1.64389056
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62981697
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.61040667
42VDR_23849224_ChIP-Seq_CD4+_Human1.60768926
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60693968
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60349903
45TTF2_22483619_ChIP-Seq_HELA_Human1.59694067
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56478003
47GATA1_22025678_ChIP-Seq_K562_Human1.52548322
48ZNF263_19887448_ChIP-Seq_K562_Human1.51739249
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50026238
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49592180
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40018824
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37095186
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33365212
54KDM5A_27292631_Chip-Seq_BREAST_Human1.32937306
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29623139
56TFEB_21752829_ChIP-Seq_HELA_Human1.28920712
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26233362
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25760787
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25484906
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25110054
61* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24841154
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23501948
63KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21998938
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19447593
65* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17870841
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16090552
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15158186
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15126014
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13354659
70CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12457420
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12344272
72* HNF4A_19822575_ChIP-Seq_HepG2_Human1.11588636
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11444090
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08670599
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.06196470
76* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05988220
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02730817
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01876931
79SOX17_20123909_ChIP-Seq_XEN_Mouse1.01439458
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.01303766
81GATA4_25053715_ChIP-Seq_YYC3_Human1.00489662
82FOXA2_19822575_ChIP-Seq_HepG2_Human0.99320694
83IRF8_22096565_ChIP-ChIP_GC-B_Human0.98613562
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97939894
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94633288
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94117510
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93541197
88* TBX20_22328084_ChIP-Seq_HEART_Mouse0.93401873
89* TBX20_22080862_ChIP-Seq_HEART_Mouse0.93401873
90AR_21909140_ChIP-Seq_LNCAP_Human0.93314602
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93113683
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91112054
93RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90414358
94E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90037065
95SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89406349
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87957495
97CHD1_26751641_Chip-Seq_LNCaP_Human0.87586094
98* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86392717
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85910244
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85649599
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85032182
102* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.83549291
103NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83325008
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83173657
105HTT_18923047_ChIP-ChIP_STHdh_Human0.82886695
106TP63_17297297_ChIP-ChIP_HaCaT_Human0.81978295
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81681919
108JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.80697913
109AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80037993
110GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79660959
111TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.79024668
112* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78778599
113GATA4_21415370_ChIP-Seq_HL-1_Mouse0.78453557
114CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78262746
115ELF1_17652178_ChIP-ChIP_JURKAT_Human0.73617286
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73316788
117* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72939166
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70081187
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69677440
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.69377355
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.68694699
122CEBPB_22108803_ChIP-Seq_LS180_Human0.66969437
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.66782602
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66589789
125* ATF3_27146783_Chip-Seq_COLON_Human0.65491137
126MYC_18358816_ChIP-ChIP_MESCs_Mouse0.64816658
127* AR_20517297_ChIP-Seq_VCAP_Human0.63744449
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.62648227
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62273147
130KAP1_22055183_ChIP-Seq_ESCs_Mouse0.62106281
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61502982
132ZFX_18555785_ChIP-Seq_MESCs_Mouse0.61465382
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.60950767
134SOX2_18692474_ChIP-Seq_MEFs_Mouse0.60758103
135GABP_17652178_ChIP-ChIP_JURKAT_Human0.60636127
136CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.60186121
137* GATA6_25053715_ChIP-Seq_YYC3_Human0.58994193
138EGR1_19032775_ChIP-ChIP_M12_Human0.58891175
139DCP1A_22483619_ChIP-Seq_HELA_Human0.58858514
140ESR1_21235772_ChIP-Seq_MCF-7_Human0.57889996
141GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.55968601
142GATA3_24758297_ChIP-Seq_MCF-7_Human0.55702026
143RAD21_21589869_ChIP-Seq_MESCs_Mouse0.55069995
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.54273997
145ERG_20517297_ChIP-Seq_VCAP_Human0.54251972
146MYC_18555785_ChIP-Seq_MESCs_Mouse0.53860928
147TBX5_21415370_ChIP-Seq_HL-1_Mouse0.53463522
148RARB_24833708_ChIP-Seq_LIVER_Mouse0.53265420
149OCT4_18692474_ChIP-Seq_MEFs_Mouse0.53010934
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.52870912
151TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.52341275
152NELFA_20434984_ChIP-Seq_ESCs_Mouse0.52223940
153* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.51382564
154* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.50944915
155TAF2_19829295_ChIP-Seq_ESCs_Human0.50619173
156* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.50046937
157HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.49876024

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.27628227
2MP0005360_urolithiasis6.03823717
3MP0005085_abnormal_gallbladder_physiolo5.04323959
4MP0005365_abnormal_bile_salt4.82042411
5MP0003806_abnormal_nucleotide_metabolis4.03900581
6MP0008875_abnormal_xenobiotic_pharmacok3.84835424
7MP0003693_abnormal_embryo_hatching3.10303598
8MP0010329_abnormal_lipoprotein_level3.04264942
9MP0003252_abnormal_bile_duct2.95560839
10MP0005332_abnormal_amino_acid2.90993376
11MP0003718_maternal_effect2.83960615
12MP0003195_calcinosis2.82048785
13MP0010234_abnormal_vibrissa_follicle2.79336327
14MP0009840_abnormal_foam_cell2.74644098
15MP0010094_abnormal_chromosome_stability2.74031393
16MP0004957_abnormal_blastocyst_morpholog2.71827943
17MP0003111_abnormal_nucleus_morphology2.44993528
18MP0005670_abnormal_white_adipose2.43137990
19MP0003646_muscle_fatigue2.30254102
20MP0002837_dystrophic_cardiac_calcinosis2.30182603
21MP0004130_abnormal_muscle_cell2.25428679
22MP0005083_abnormal_biliary_tract2.18005173
23MP0006036_abnormal_mitochondrial_physio2.17440686
24MP0003077_abnormal_cell_cycle2.15836475
25MP0001666_abnormal_nutrient_absorption2.10742326
26MP0003191_abnormal_cellular_cholesterol2.10214568
27MP0002118_abnormal_lipid_homeostasis2.02973235
28MP0000609_abnormal_liver_physiology1.98779593
29MP0005319_abnormal_enzyme/_coenzyme1.91533550
30MP0003186_abnormal_redox_activity1.90206636
31MP0008932_abnormal_embryonic_tissue1.89865073
32MP0004019_abnormal_vitamin_homeostasis1.86895408
33MP0005666_abnormal_adipose_tissue1.85632821
34MP0008058_abnormal_DNA_repair1.81452157
35MP0004233_abnormal_muscle_weight1.71402953
36MP0005464_abnormal_platelet_physiology1.70464464
37MP0003941_abnormal_skin_development1.68529053
38MP0005330_cardiomyopathy1.66013719
39MP0005584_abnormal_enzyme/coenzyme_acti1.62162813
40MP0009643_abnormal_urine_homeostasis1.61239266
41MP0001764_abnormal_homeostasis1.57744057
42MP0002971_abnormal_brown_adipose1.54770121
43MP0005451_abnormal_body_composition1.51637876
44MP0001730_embryonic_growth_arrest1.50485581
45MP0002877_abnormal_melanocyte_morpholog1.47822761
46MP0004084_abnormal_cardiac_muscle1.46600906
47MP0002138_abnormal_hepatobiliary_system1.45091742
48MP0005058_abnormal_lysosome_morphology1.40608378
49MP0004185_abnormal_adipocyte_glucose1.35105700
50MP0003705_abnormal_hypodermis_morpholog1.34096094
51MP0008007_abnormal_cellular_replicative1.32057992
52MP0004215_abnormal_myocardial_fiber1.24831872
53MP0006035_abnormal_mitochondrial_morpho1.21237647
54MP0003221_abnormal_cardiomyocyte_apopto1.20573242
55MP0005501_abnormal_skin_physiology1.19103127
56MP0000372_irregular_coat_pigmentation1.18804835
57MP0003950_abnormal_plasma_membrane1.18698782
58MP0009697_abnormal_copulation1.17448567
59MP0004036_abnormal_muscle_relaxation1.16022037
60MP0001881_abnormal_mammary_gland1.15260336
61MP0008775_abnormal_heart_ventricle1.11239657
62MP0003656_abnormal_erythrocyte_physiolo1.11223473
63MP0000598_abnormal_liver_morphology1.10632716
64MP0000350_abnormal_cell_proliferation1.09356000
65MP0000749_muscle_degeneration1.09208224
66MP0005385_cardiovascular_system_phenoty1.07163416
67MP0001544_abnormal_cardiovascular_syste1.07163416
68MP0000358_abnormal_cell_content/1.05663129
69MP0003868_abnormal_feces_composition1.03143103
70MP0002078_abnormal_glucose_homeostasis1.02709064
71MP0005266_abnormal_metabolism1.02375864
72MP0005535_abnormal_body_temperature1.01787395
73MP0005375_adipose_tissue_phenotype1.01562805
74MP0004087_abnormal_muscle_fiber1.00360605
75MP0004043_abnormal_pH_regulation0.99416277
76MP0001727_abnormal_embryo_implantation0.98951267
77MP0005636_abnormal_mineral_homeostasis0.98504613
78MP0001756_abnormal_urination0.98282313
79MP0003786_premature_aging0.97349000
80MP0001697_abnormal_embryo_size0.97181456
81MP0005334_abnormal_fat_pad0.96197362
82MP0004145_abnormal_muscle_electrophysio0.95566366
83MP0002972_abnormal_cardiac_muscle0.95442775
84MP0010352_gastrointestinal_tract_polyps0.94755518
85MP0009763_increased_sensitivity_to0.93408991
86MP0006138_congestive_heart_failure0.92689759
87MP0002269_muscular_atrophy0.92434251
88MP0005380_embryogenesis_phenotype0.92096026
89MP0001672_abnormal_embryogenesis/_devel0.92096026
90MP0000751_myopathy0.91818039
91MP0010368_abnormal_lymphatic_system0.88991349
92MP0010630_abnormal_cardiac_muscle0.88786833
93MP0003011_delayed_dark_adaptation0.88194409
94MP0002080_prenatal_lethality0.87789972
95MP0005376_homeostasis/metabolism_phenot0.86594724
96MP0009764_decreased_sensitivity_to0.86130996
97MP0003984_embryonic_growth_retardation0.84849008
98MP0001661_extended_life_span0.84713667
99MP0009115_abnormal_fat_cell0.83361993
100MP0000313_abnormal_cell_death0.82474604
101MP0008469_abnormal_protein_level0.81823561
102MP0001853_heart_inflammation0.81741854
103MP0009642_abnormal_blood_homeostasis0.81544215
104MP0005620_abnormal_muscle_contractility0.81494313
105MP0002088_abnormal_embryonic_growth/wei0.81133047
106MP0000490_abnormal_crypts_of0.80793182
107MP0002332_abnormal_exercise_endurance0.80176798
108MP0002970_abnormal_white_adipose0.78944073
109MP0005084_abnormal_gallbladder_morpholo0.76866718
110MP0005647_abnormal_sex_gland0.76011892
111MP0002160_abnormal_reproductive_system0.75586416
112MP0000750_abnormal_muscle_regeneration0.75216213
113MP0005187_abnormal_penis_morphology0.75180243
114MP0003315_abnormal_perineum_morphology0.74361599
115MP0004264_abnormal_extraembryonic_tissu0.73970985
116MP0000759_abnormal_skeletal_muscle0.73487563
117MP0010307_abnormal_tumor_latency0.72676828
118MP0003724_increased_susceptibility_to0.72005656
119MP0002019_abnormal_tumor_incidence0.71155027
120MP0002254_reproductive_system_inflammat0.69630307
121MP0002876_abnormal_thyroid_physiology0.69578723
122MP0008057_abnormal_DNA_replication0.69274922
123MP0000343_altered_response_to0.69058716
124MP0000230_abnormal_systemic_arterial0.66802345
125MP0002136_abnormal_kidney_physiology0.65893610
126MP0005448_abnormal_energy_balance0.63748760
127MP0004147_increased_porphyrin_level0.59821140
128MP0003828_pulmonary_edema0.57635427
129MP0005165_increased_susceptibility_to0.57153037
130MP0002796_impaired_skin_barrier0.53744371
131MP0000747_muscle_weakness0.53125571
132MP0003137_abnormal_impulse_conducting0.52481569
133MP0005220_abnormal_exocrine_pancreas0.52222199
134MP0008438_abnormal_cutaneous_collagen0.51144554
135MP0002106_abnormal_muscle_physiology0.51052381
136MP0000604_amyloidosis0.50003540
137MP0004782_abnormal_surfactant_physiolog0.49859511
138MP0005408_hypopigmentation0.48490154
139MP0003567_abnormal_fetal_cardiomyocyte0.46744242
140MP0004484_altered_response_of0.45915697
141MP0005395_other_phenotype0.45690871
142MP0005275_abnormal_skin_tensile0.45456773

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)5.35357893
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.07134828
3Hyperammonemia (HP:0001987)5.00689209
4Abnormality of serine family amino acid metabolism (HP:0010894)4.79177660
5Abnormality of glycine metabolism (HP:0010895)4.79177660
6Intrahepatic cholestasis (HP:0001406)4.78025385
7* Abnormality of fatty-acid metabolism (HP:0004359)4.75408097
8Xanthomatosis (HP:0000991)4.66393728
9* Hypoglycemic coma (HP:0001325)4.59666043
10Deep venous thrombosis (HP:0002625)4.57973780
11Ketosis (HP:0001946)4.57648604
12Hyperglycinemia (HP:0002154)4.49320204
13Abnormality of monocarboxylic acid metabolism (HP:0010996)4.35631266
14Hypobetalipoproteinemia (HP:0003563)4.23074163
15* Abnormality of dicarboxylic acid metabolism (HP:0010995)4.22855321
16* Dicarboxylic aciduria (HP:0003215)4.22855321
17Ketoacidosis (HP:0001993)4.19952037
18Hyperlipoproteinemia (HP:0010980)4.11555549
19Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.04099629
20Prolonged partial thromboplastin time (HP:0003645)3.87653702
21Myoglobinuria (HP:0002913)3.82939325
22Hypolipoproteinemia (HP:0010981)3.77692952
23Hypoalphalipoproteinemia (HP:0003233)3.75064159
24Cerebral edema (HP:0002181)3.65013840
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.60441242
26Complement deficiency (HP:0004431)3.53761958
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.53147054
28Abnormality of serum amino acid levels (HP:0003112)3.46605705
29Lethargy (HP:0001254)3.45121576
30Abnormal gallbladder physiology (HP:0012438)3.42370286
31Cholecystitis (HP:0001082)3.42370286
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.41823036
33Rhabdomyolysis (HP:0003201)3.40878637
34Metabolic acidosis (HP:0001942)3.29183706
35Epidermoid cyst (HP:0200040)3.26395996
36* Hepatic necrosis (HP:0002605)3.22984312
37Increased muscle lipid content (HP:0009058)3.03252755
38Abnormality of sulfur amino acid metabolism (HP:0004339)3.01790626
39Acute encephalopathy (HP:0006846)2.98504771
40Abnormality of methionine metabolism (HP:0010901)2.95173584
41* Generalized aminoaciduria (HP:0002909)2.88862487
42Nemaline bodies (HP:0003798)2.88674303
43Abnormality of the common coagulation pathway (HP:0010990)2.84600584
44Joint hemorrhage (HP:0005261)2.80239602
45Abnormality of purine metabolism (HP:0004352)2.75742538
46Fat malabsorption (HP:0002630)2.75542620
47Microvesicular hepatic steatosis (HP:0001414)2.74871811
48Gout (HP:0001997)2.74472488
49* Vomiting (HP:0002013)2.73009562
50Muscle fiber inclusion bodies (HP:0100299)2.70983693
51Delayed CNS myelination (HP:0002188)2.70795659
52Progressive muscle weakness (HP:0003323)2.69258031
53Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.68153109
54Abnormality of nucleobase metabolism (HP:0010932)2.67810128
55Hyperbilirubinemia (HP:0002904)2.64643760
56Palpitations (HP:0001962)2.64253271
57* Nausea (HP:0002018)2.64046133
58Reduced antithrombin III activity (HP:0001976)2.63353140
59Increased serum pyruvate (HP:0003542)2.62900905
60Abnormality of glycolysis (HP:0004366)2.62900905
61Abnormality of the intrinsic pathway (HP:0010989)2.60051589
62Hypercholesterolemia (HP:0003124)2.59632269
63Abnormality of complement system (HP:0005339)2.56192166
64Lactic acidosis (HP:0003128)2.55198654
65Exercise intolerance (HP:0003546)2.54775276
66Abnormality of pyrimidine metabolism (HP:0004353)2.51945308
67Abnormal mitochondria in muscle tissue (HP:0008316)2.51470526
68Hepatocellular necrosis (HP:0001404)2.49580528
69* Proximal tubulopathy (HP:0000114)2.49075926
70Increased serum lactate (HP:0002151)2.47761991
71Hydroxyprolinuria (HP:0003080)2.39272597
72Abnormality of proline metabolism (HP:0010907)2.39272597
73Methylmalonic aciduria (HP:0012120)2.38340894
74Hyperuricemia (HP:0002149)2.35930846
75Increased purine levels (HP:0004368)2.35930846
76Right ventricular cardiomyopathy (HP:0011663)2.34299527
77Skin nodule (HP:0200036)2.34293202
78Acute necrotizing encephalopathy (HP:0006965)2.33931790
79Abnormal cartilage morphology (HP:0002763)2.29293949
80Hypoglycemic seizures (HP:0002173)2.27804358
81Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27223422
82Increased intramyocellular lipid droplets (HP:0012240)2.25672739
83Exercise-induced myalgia (HP:0003738)2.25515177
84Type I transferrin isoform profile (HP:0003642)2.25307708
85Progressive macrocephaly (HP:0004481)2.25047472
86Chromsome breakage (HP:0040012)2.23424350
87Abnormality of alanine metabolism (HP:0010916)2.20679674
88Hyperalaninemia (HP:0003348)2.20679674
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20679674
90Conjunctival hamartoma (HP:0100780)2.20625965
91Ragged-red muscle fibers (HP:0003200)2.20171842
92Hyperinsulinemic hypoglycemia (HP:0000825)2.19461466
93Ventricular tachycardia (HP:0004756)2.18995425
94Multiple enchondromatosis (HP:0005701)2.17958270
95Increased CSF lactate (HP:0002490)2.17714558
96Progressive external ophthalmoplegia (HP:0000590)2.16862214
97Pancreatitis (HP:0001733)2.16835644
98Hyperglycemia (HP:0003074)2.16385957
99* Glycosuria (HP:0003076)2.16088384
100* Abnormality of urine glucose concentration (HP:0011016)2.16088384
101Hepatocellular carcinoma (HP:0001402)2.16030336
102Increased hepatocellular lipid droplets (HP:0006565)2.15381837
103Myocardial infarction (HP:0001658)2.14080209
104Cholelithiasis (HP:0001081)2.13084758
105Conjugated hyperbilirubinemia (HP:0002908)2.10918107
106Exercise-induced muscle cramps (HP:0003710)2.10913376
107Increased mean platelet volume (HP:0011877)2.10651076
108Hypertriglyceridemia (HP:0002155)2.10484951
109Abnormal gallbladder morphology (HP:0012437)2.09734622
110Steatorrhea (HP:0002570)2.09659278
111Late onset (HP:0003584)2.09378700
112Sudden death (HP:0001699)2.09107558
113Petechiae (HP:0000967)2.08023438
114Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07730990
115Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07730990
116Renal Fanconi syndrome (HP:0001994)2.07390092
117Abnormality of the anterior horn cell (HP:0006802)2.05914773
118Degeneration of anterior horn cells (HP:0002398)2.05914773
119Muscle stiffness (HP:0003552)2.03862869
120Megaloblastic anemia (HP:0001889)2.03463848
121Macrocytic anemia (HP:0001972)2.03021898
122Neoplasm of head and neck (HP:0012288)2.01308993
123Esophageal neoplasm (HP:0100751)2.01308993
124Respiratory failure (HP:0002878)2.01149399
1253-Methylglutaconic aciduria (HP:0003535)1.98453521
126* Renal cortical cysts (HP:0000803)1.96143750
127Mitochondrial inheritance (HP:0001427)1.95831410
128Paralysis (HP:0003470)1.95765464
129Bundle branch block (HP:0011710)1.94729052
130Lipid accumulation in hepatocytes (HP:0006561)1.93914618
131Aplastic anemia (HP:0001915)1.93897495
132Menorrhagia (HP:0000132)1.89687934
133Acanthocytosis (HP:0001927)1.87050755
134Spontaneous abortion (HP:0005268)1.84033566
135Fasciculations (HP:0002380)1.82788479
136Reticulocytopenia (HP:0001896)1.82051448
137Hypokinesia (HP:0002375)1.80988432
138Testicular atrophy (HP:0000029)1.79831959
139Neck muscle weakness (HP:0000467)1.79354638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.27938174
2PDK43.54276259
3PDK33.54276259
4BUB13.48969710
5SCYL23.24859704
6TRIB33.09093792
7ERN12.86843844
8PKN22.71363445
9EIF2AK32.62093454
10SIK12.48084781
11ARAF2.41429502
12FGFR42.41304297
13MST42.33108493
14PDK22.21025220
15SRPK12.20788438
16TTN2.20316322
17NEK12.19067773
18TESK22.08750515
19OBSCN2.01172944
20NEK91.96483076
21FLT31.92689735
22STK38L1.91580966
23NME21.89139240
24CDC71.85090715
25MAP3K121.83438204
26VRK21.82101373
27MYLK1.78857748
28LMTK21.77808579
29RPS6KB21.73028739
30INSRR1.60606315
31PINK11.59712150
32PIM21.48188501
33TIE11.46956665
34MST1R1.45349208
35WEE11.42564369
36KDR1.41889762
37TESK11.39262067
38PIK3CG1.38195201
39MAP2K31.33488490
40PAK41.24793579
41MAPK111.24579681
42EEF2K1.23037195
43EIF2AK11.21233344
44LATS11.21004973
45MAP3K31.19449572
46CDK81.17001424
47PRKAA21.15838602
48IRAK31.14815919
49ABL21.13900087
50STK241.13434163
51CDK71.08942799
52TYK21.08309661
53PIK3CA1.07069286
54NME11.03268517
55AURKB1.03248937
56MAP3K91.01620938
57ERBB41.01294738
58TSSK61.01220458
59VRK11.00817606
60BRAF1.00585785
61AURKA0.98073673
62PHKG20.96697043
63PHKG10.96697043
64CCNB10.95690345
65TGFBR20.95552858
66LIMK10.94882558
67TRIM280.94848594
68PLK10.94629076
69MAP3K110.93471026
70WNK40.90297238
71RAF10.82488265
72PTK60.82412005
73CDK40.79321142
74PLK40.78572269
75PLK30.78517635
76PRKAA10.77785467
77TBK10.77428724
78MUSK0.74086506
79MAP3K80.72751410
80BRSK10.72723209
81CHEK20.71580465
82TLK10.71389055
83FRK0.70990951
84JAK20.67492179
85CDK90.67116693
86CDK60.67070212
87BMPR20.66380572
88EPHA30.66279395
89MAP3K50.64792549
90ZAK0.64683358
91MAPKAPK30.64668254
92MAP3K70.63367276
93TAOK30.63301720
94WNK30.62825362
95PRKCI0.60262390
96CHEK10.59369452
97MAPK120.58921388
98BMPR1B0.58572728
99CAMK1D0.57977539
100JAK10.56819888
101ACVR1B0.56373670
102ATR0.56258088
103MAP2K60.56048192
104STK40.53855312
105PRKACG0.53800927
106KSR20.53189045
107CSNK2A20.53153701
108DAPK30.52804220
109SMG10.52432240
110CSNK2A10.52305182
111EIF2AK20.52069509
112MAP2K10.51981248
113LRRK20.51794335
114TAOK20.51242665
115DAPK10.51198431
116CLK10.49481425
117MAPKAPK50.48042898
118ILK0.46833425
119STK30.44710450
120PAK10.44382840
121MAP2K40.44338199
122RPS6KA50.43477797
123MAP3K140.43218593
124TTK0.42425491
125RPS6KA40.40141422
126EPHB20.39812113
127EPHA20.39679330
128STK160.39392537
129TRPM70.39122706
130BRSK20.38964996
131GRK70.38891694
132PDPK10.38450470
133DYRK1B0.38377924
134PRKD10.37984012
135MAPK40.37528763
136TGFBR10.37522884
137CSNK1G30.36991235
138PBK0.36721157
139MET0.36482343
140FER0.36005702
141RIPK10.34671259
142ERBB30.32414349
143CAMK2D0.32303786
144IRAK10.32270571
145CAMK2G0.31483601
146GSK3A0.29664762
147AKT20.28539143
148PAK30.28006763
149LATS20.27796659
150NUAK10.27718578
151PRKG20.27565943
152IGF1R0.24694899
153FGFR30.24142776
154EPHB10.23114686
155MAPK150.22889689
156STK100.22881002
157MTOR0.22732501
158ERBB20.22103366
159PDK10.21846176

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000713.37061523
2Propanoate metabolism_Homo sapiens_hsa006403.30868253
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.26753091
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.20985858
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.13807018
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.09394112
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.91404673
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81729473
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.63484501
10Fatty acid metabolism_Homo sapiens_hsa012122.53925670
11Tryptophan metabolism_Homo sapiens_hsa003802.43926154
12Mismatch repair_Homo sapiens_hsa034302.42424525
13DNA replication_Homo sapiens_hsa030302.37929405
14Butanoate metabolism_Homo sapiens_hsa006502.29466362
15Nitrogen metabolism_Homo sapiens_hsa009102.29427788
16Arginine biosynthesis_Homo sapiens_hsa002202.21559265
17PPAR signaling pathway_Homo sapiens_hsa033202.19396502
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14796431
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.12495148
20Peroxisome_Homo sapiens_hsa041462.11156391
21Carbon metabolism_Homo sapiens_hsa012002.08362261
22Pyruvate metabolism_Homo sapiens_hsa006202.04958507
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99417817
24beta-Alanine metabolism_Homo sapiens_hsa004101.87113600
25Complement and coagulation cascades_Homo sapiens_hsa046101.76565229
26Ribosome_Homo sapiens_hsa030101.75643532
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74031408
28Fatty acid elongation_Homo sapiens_hsa000621.71643565
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65497768
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54155859
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51904547
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51210664
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49949946
34Chemical carcinogenesis_Homo sapiens_hsa052041.49000734
35Caffeine metabolism_Homo sapiens_hsa002321.48678685
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.48002308
37Biosynthesis of amino acids_Homo sapiens_hsa012301.42365549
38Nucleotide excision repair_Homo sapiens_hsa034201.40122883
39Base excision repair_Homo sapiens_hsa034101.37152854
40Sulfur metabolism_Homo sapiens_hsa009201.36402103
41Histidine metabolism_Homo sapiens_hsa003401.33552435
42Phenylalanine metabolism_Homo sapiens_hsa003601.33020899
43Starch and sucrose metabolism_Homo sapiens_hsa005001.32393541
44Selenocompound metabolism_Homo sapiens_hsa004501.31439509
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.27551038
46Retinol metabolism_Homo sapiens_hsa008301.25404860
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.22420253
48Folate biosynthesis_Homo sapiens_hsa007901.21479793
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19382253
50Homologous recombination_Homo sapiens_hsa034401.15958162
51Tyrosine metabolism_Homo sapiens_hsa003501.15830161
52Fat digestion and absorption_Homo sapiens_hsa049751.14345178
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10477764
54Staphylococcus aureus infection_Homo sapiens_hsa051501.09817826
55RNA transport_Homo sapiens_hsa030131.06257791
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98990696
57Bile secretion_Homo sapiens_hsa049760.96987694
58Arginine and proline metabolism_Homo sapiens_hsa003300.93666176
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92939690
60Cell cycle_Homo sapiens_hsa041100.92265937
61Spliceosome_Homo sapiens_hsa030400.91052990
62Oxidative phosphorylation_Homo sapiens_hsa001900.90288811
63Glutathione metabolism_Homo sapiens_hsa004800.90128872
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88809157
65Parkinsons disease_Homo sapiens_hsa050120.87476100
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.87039729
67Protein export_Homo sapiens_hsa030600.85164720
68Sulfur relay system_Homo sapiens_hsa041220.83916601
69Pentose phosphate pathway_Homo sapiens_hsa000300.82993441
70Lysine degradation_Homo sapiens_hsa003100.81265187
71Glycerolipid metabolism_Homo sapiens_hsa005610.80923203
72RNA polymerase_Homo sapiens_hsa030200.77426817
73ABC transporters_Homo sapiens_hsa020100.76829374
74Fatty acid biosynthesis_Homo sapiens_hsa000610.76203522
75Vitamin B6 metabolism_Homo sapiens_hsa007500.76199842
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74609395
77Purine metabolism_Homo sapiens_hsa002300.71699744
78Vitamin digestion and absorption_Homo sapiens_hsa049770.68046392
79Fanconi anemia pathway_Homo sapiens_hsa034600.66520853
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.65207454
81One carbon pool by folate_Homo sapiens_hsa006700.63443435
82Metabolic pathways_Homo sapiens_hsa011000.62694840
83Systemic lupus erythematosus_Homo sapiens_hsa053220.60941308
84Non-homologous end-joining_Homo sapiens_hsa034500.57758626
85Galactose metabolism_Homo sapiens_hsa000520.54712539
86Fructose and mannose metabolism_Homo sapiens_hsa000510.54405075
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53761395
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53334746
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.49338036
90RNA degradation_Homo sapiens_hsa030180.49333403
91Steroid biosynthesis_Homo sapiens_hsa001000.48967717
92Basal transcription factors_Homo sapiens_hsa030220.48828026
93Alzheimers disease_Homo sapiens_hsa050100.47969652
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45618910
95Huntingtons disease_Homo sapiens_hsa050160.44036418
96N-Glycan biosynthesis_Homo sapiens_hsa005100.42321382
97Insulin resistance_Homo sapiens_hsa049310.42204072
98Other glycan degradation_Homo sapiens_hsa005110.38210812
99Cardiac muscle contraction_Homo sapiens_hsa042600.34411502
100Thyroid cancer_Homo sapiens_hsa052160.33083671
101AMPK signaling pathway_Homo sapiens_hsa041520.26775172
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25320416
103Glucagon signaling pathway_Homo sapiens_hsa049220.24149073
104Oocyte meiosis_Homo sapiens_hsa041140.22749248
105Proteasome_Homo sapiens_hsa030500.21710110
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20067523
107Linoleic acid metabolism_Homo sapiens_hsa005910.18507010
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.12033502
109Insulin signaling pathway_Homo sapiens_hsa049100.10107210
110Arachidonic acid metabolism_Homo sapiens_hsa005900.06913926
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.05956902
112Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1389716
113Dilated cardiomyopathy_Homo sapiens_hsa05414-0.1351891
114Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1344132
115Protein digestion and absorption_Homo sapiens_hsa04974-0.1295923
116Renin-angiotensin system_Homo sapiens_hsa04614-0.0932695
117Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0439385
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0437274
119Legionellosis_Homo sapiens_hsa05134-0.0348366
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0314246
121Regulation of autophagy_Homo sapiens_hsa04140-0.0134548
122Prion diseases_Homo sapiens_hsa05020-0.0078616
123Pyrimidine metabolism_Homo sapiens_hsa00240-0.0019216

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