ETFB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.85156506
2L-phenylalanine metabolic process (GO:0006558)4.85156506
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.81709475
4L-phenylalanine catabolic process (GO:0006559)4.81709475
5glyoxylate metabolic process (GO:0046487)4.80288963
6lysine catabolic process (GO:0006554)4.59953397
7lysine metabolic process (GO:0006553)4.59953397
8fatty acid beta-oxidation (GO:0006635)4.43998828
9aromatic amino acid family catabolic process (GO:0009074)4.32771614
10tricarboxylic acid cycle (GO:0006099)4.27433886
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.21705915
12branched-chain amino acid catabolic process (GO:0009083)4.20682747
13valine metabolic process (GO:0006573)4.14026331
14amino-acid betaine metabolic process (GO:0006577)4.08005036
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.04444301
16fatty acid oxidation (GO:0019395)4.03745479
172-oxoglutarate metabolic process (GO:0006103)4.02840606
18sulfur amino acid catabolic process (GO:0000098)4.02615524
19oxidative phosphorylation (GO:0006119)3.99682488
20kynurenine metabolic process (GO:0070189)3.98418846
21lipid oxidation (GO:0034440)3.96197323
22fatty acid catabolic process (GO:0009062)3.95103844
23tryptophan catabolic process (GO:0006569)3.93472978
24indole-containing compound catabolic process (GO:0042436)3.93472978
25indolalkylamine catabolic process (GO:0046218)3.93472978
26ATP synthesis coupled proton transport (GO:0015986)3.89005523
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.89005523
28branched-chain amino acid metabolic process (GO:0009081)3.88704352
29intestinal cholesterol absorption (GO:0030299)3.84439507
30carnitine metabolic process (GO:0009437)3.82351733
31very-low-density lipoprotein particle assembly (GO:0034379)3.81856338
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.81661252
33cellular ketone body metabolic process (GO:0046950)3.78838631
34regulation of triglyceride catabolic process (GO:0010896)3.77609131
35cysteine metabolic process (GO:0006534)3.77094775
36short-chain fatty acid metabolic process (GO:0046459)3.76311779
37tryptophan metabolic process (GO:0006568)3.72454071
38low-density lipoprotein particle remodeling (GO:0034374)3.69766603
39cholesterol efflux (GO:0033344)3.68156078
40* respiratory electron transport chain (GO:0022904)3.67302859
41regulation of sequestering of triglyceride (GO:0010889)3.66420209
42aldehyde catabolic process (GO:0046185)3.64185292
43alpha-linolenic acid metabolic process (GO:0036109)3.62616529
44monocarboxylic acid catabolic process (GO:0072329)3.62315967
45acetyl-CoA metabolic process (GO:0006084)3.60791222
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.59941397
47regulation of fibrinolysis (GO:0051917)3.59672940
48tricarboxylic acid metabolic process (GO:0072350)3.59381960
49NADH metabolic process (GO:0006734)3.58854651
50* electron transport chain (GO:0022900)3.57076842
51bile acid biosynthetic process (GO:0006699)3.52101943
52serine family amino acid catabolic process (GO:0009071)3.51513483
53plasma lipoprotein particle assembly (GO:0034377)3.50564102
54aspartate family amino acid catabolic process (GO:0009068)3.50114032
55arginine metabolic process (GO:0006525)3.47648587
56fatty acid transmembrane transport (GO:1902001)3.46058161
57regulation of complement activation (GO:0030449)3.45986438
58protein complex biogenesis (GO:0070271)3.45289373
59reverse cholesterol transport (GO:0043691)3.42766320
60ethanol oxidation (GO:0006069)3.39643277
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38349476
62mitochondrial respiratory chain complex I assembly (GO:0032981)3.38349476
63NADH dehydrogenase complex assembly (GO:0010257)3.38349476
64glycine metabolic process (GO:0006544)3.37455282
65alpha-amino acid catabolic process (GO:1901606)3.36633722
66carnitine shuttle (GO:0006853)3.35935633
67organic acid catabolic process (GO:0016054)3.31702410
68carboxylic acid catabolic process (GO:0046395)3.31702410
69exogenous drug catabolic process (GO:0042738)3.31600568
70serine family amino acid biosynthetic process (GO:0009070)3.29922365
71aromatic amino acid family metabolic process (GO:0009072)3.27491777
72ketone body metabolic process (GO:1902224)3.26639973
73drug catabolic process (GO:0042737)3.24746420
74negative regulation of cholesterol transport (GO:0032375)3.24623944
75negative regulation of sterol transport (GO:0032372)3.24623944
76cellular amino acid catabolic process (GO:0009063)3.23595651
77oxaloacetate metabolic process (GO:0006107)3.23369083
78homocysteine metabolic process (GO:0050667)3.23177323
79serine family amino acid metabolic process (GO:0009069)3.21968554
80succinate metabolic process (GO:0006105)3.16695890
81blood coagulation, intrinsic pathway (GO:0007597)3.15870131
82plasma lipoprotein particle organization (GO:0071827)3.15256423
83killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.14601085
84disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.14601085
85biotin metabolic process (GO:0006768)3.12988270
86mitochondrial respiratory chain complex assembly (GO:0033108)3.10681722
87quinone biosynthetic process (GO:1901663)3.10616685
88ubiquinone biosynthetic process (GO:0006744)3.10616685
89regulation of mitochondrial translation (GO:0070129)3.08660226
90protein carboxylation (GO:0018214)3.08507490
91peptidyl-glutamic acid carboxylation (GO:0017187)3.08507490
92urea cycle (GO:0000050)3.06734352
93urea metabolic process (GO:0019627)3.06734352
94arginine catabolic process (GO:0006527)3.03414246
95nitrogen cycle metabolic process (GO:0071941)2.98072622
96oxidative demethylation (GO:0070989)2.96597339
97sequestering of actin monomers (GO:0042989)2.96132423
98complement activation, alternative pathway (GO:0006957)2.95938396
99high-density lipoprotein particle remodeling (GO:0034375)2.95805921
100flavonoid metabolic process (GO:0009812)2.95495445
101NAD metabolic process (GO:0019674)2.95285748
102coenzyme catabolic process (GO:0009109)2.94880602
103protein-lipid complex remodeling (GO:0034368)2.94830329
104macromolecular complex remodeling (GO:0034367)2.94830329
105plasma lipoprotein particle remodeling (GO:0034369)2.94830329
106regulation of cholesterol esterification (GO:0010872)2.93700694
107protein-lipid complex assembly (GO:0065005)2.93250418
108bile acid metabolic process (GO:0008206)2.93178379
109acylglycerol homeostasis (GO:0055090)2.93128126
110triglyceride homeostasis (GO:0070328)2.93128126
111polyketide metabolic process (GO:0030638)2.93122837
112doxorubicin metabolic process (GO:0044598)2.93122837
113daunorubicin metabolic process (GO:0044597)2.93122837
114behavioral response to nicotine (GO:0035095)2.92133908
115negative regulation of fibrinolysis (GO:0051918)2.92003222
116tyrosine metabolic process (GO:0006570)2.91627043
117pyrimidine nucleobase catabolic process (GO:0006208)2.91421968
118regulation of cholesterol metabolic process (GO:0090181)2.91245547
119positive regulation of lipoprotein lipase activity (GO:0051006)2.88247067
120positive regulation of triglyceride lipase activity (GO:0061365)2.88247067
121regulation of protein activation cascade (GO:2000257)2.86397960
122protein-lipid complex subunit organization (GO:0071825)2.86134273
123heart process (GO:0003015)2.85619110
124heart contraction (GO:0060047)2.85619110
125xenobiotic catabolic process (GO:0042178)2.84764394
126cellular biogenic amine catabolic process (GO:0042402)2.83641766
127amine catabolic process (GO:0009310)2.83641766
128response to mercury ion (GO:0046689)2.83423047
129regulation of plasminogen activation (GO:0010755)2.83397601
130plasma lipoprotein particle clearance (GO:0034381)2.83188733
131drug transmembrane transport (GO:0006855)2.82708416
132thioester metabolic process (GO:0035383)2.82436857
133acyl-CoA metabolic process (GO:0006637)2.82436857
134regulation of hexokinase activity (GO:1903299)2.82236710
135regulation of glucokinase activity (GO:0033131)2.82236710
136regulation of fatty acid oxidation (GO:0046320)2.82162827
137benzene-containing compound metabolic process (GO:0042537)2.81937690
138amino-acid betaine transport (GO:0015838)2.81771635
139quinone metabolic process (GO:1901661)2.79343530
140water-soluble vitamin biosynthetic process (GO:0042364)2.79306130
141cofactor catabolic process (GO:0051187)2.78015937
142phospholipid efflux (GO:0033700)2.77341912
143diacylglycerol metabolic process (GO:0046339)2.76578619
144hydrogen ion transmembrane transport (GO:1902600)2.76294250
145ATP biosynthetic process (GO:0006754)2.75738702
146neurotransmitter catabolic process (GO:0042135)2.71448789
147negative regulation of lipase activity (GO:0060192)2.63241747
148aminoglycoside antibiotic metabolic process (GO:0030647)2.63102275
149drug metabolic process (GO:0017144)2.61762226
150epoxygenase P450 pathway (GO:0019373)2.59854855
151protein-cofactor linkage (GO:0018065)2.57483820
152glutamate metabolic process (GO:0006536)2.57433227
153regulation of cholesterol biosynthetic process (GO:0045540)2.54573121
154viral transcription (GO:0019083)2.52766131
155L-ascorbic acid metabolic process (GO:0019852)2.52311919
156cholesterol homeostasis (GO:0042632)2.52205009
157indolalkylamine metabolic process (GO:0006586)2.52158732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.75988161
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.11769000
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.48742426
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.13848998
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.63950262
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.39271166
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.32081505
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.19269280
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.17691191
10EZH2_22144423_ChIP-Seq_EOC_Human3.07571576
11* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.84218395
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.81310536
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73911693
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.66616711
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.60951362
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49856012
17ZNF274_21170338_ChIP-Seq_K562_Hela2.42480601
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35988653
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24997425
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.18656025
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.15397072
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.13577082
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11314382
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.09889108
25* SRF_21415370_ChIP-Seq_HL-1_Mouse2.07311394
26VDR_22108803_ChIP-Seq_LS180_Human1.98838878
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92628035
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92363095
29* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.88961148
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87685260
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.87675815
32GATA1_22025678_ChIP-Seq_K562_Human1.87428056
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79633140
34* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.75728416
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68583396
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.65508165
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64571341
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59424392
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.56417061
40IGF1R_20145208_ChIP-Seq_DFB_Human1.55788756
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.49351055
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49290142
43ERA_21632823_ChIP-Seq_H3396_Human1.45289630
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43937371
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43808411
46E2F7_22180533_ChIP-Seq_HELA_Human1.43331994
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43001032
48* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40917323
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39464508
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.39425992
51DCP1A_22483619_ChIP-Seq_HELA_Human1.37997738
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37448295
53* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36841732
54* REST_18959480_ChIP-ChIP_MESCs_Mouse1.35766529
55* HNF4A_19822575_ChIP-Seq_HepG2_Human1.35683209
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34036966
57REST_21632747_ChIP-Seq_MESCs_Mouse1.33203911
58* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31009833
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27592935
60* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27013314
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.26807704
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24694333
63OCT4_20526341_ChIP-Seq_ESCs_Human1.24445755
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.23983552
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22545203
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22193607
67VDR_23849224_ChIP-Seq_CD4+_Human1.21125150
68FOXP3_21729870_ChIP-Seq_TREG_Human1.17710453
69* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17266861
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17200024
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17111325
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14183266
73* TAF2_19829295_ChIP-Seq_ESCs_Human1.13859611
74XRN2_22483619_ChIP-Seq_HELA_Human1.13177932
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13163428
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13053792
77GBX2_23144817_ChIP-Seq_PC3_Human1.12702339
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12625630
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11651642
80PHF8_20622854_ChIP-Seq_HELA_Human1.10849301
81E2F1_20622854_ChIP-Seq_HELA_Human1.10805370
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09056555
83* RAC3_21632823_ChIP-Seq_H3396_Human1.08791825
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08476429
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08102128
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08058232
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06687320
88CLOCK_20551151_ChIP-Seq_293T_Human1.06455769
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06379333
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06296064
91GABP_19822575_ChIP-Seq_HepG2_Human1.05989258
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05398632
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05271504
94TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04888918
95CTCF_20526341_ChIP-Seq_ESCs_Human1.04186238
96* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04115594
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04091507
98* MYC_19829295_ChIP-Seq_ESCs_Human1.04059135
99CTCF_27219007_Chip-Seq_Bcells_Human1.04014395
100* FOXA2_19822575_ChIP-Seq_HepG2_Human1.03739951
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03555921
102PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02519773
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.01311591
104SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01266462
105MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00973115
106RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00641958
107EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00564013
108P53_21459846_ChIP-Seq_SAOS-2_Human1.00523442
109P68_20966046_ChIP-Seq_HELA_Human0.99620697
110FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99581572
111NANOG_20526341_ChIP-Seq_ESCs_Human0.99225243
112TP53_22573176_ChIP-Seq_HFKS_Human0.98748635
113FOXP1_21924763_ChIP-Seq_HESCs_Human0.96782938
114GATA3_21878914_ChIP-Seq_MCF-7_Human0.96394274
115ZNF263_19887448_ChIP-Seq_K562_Human0.95270226
116EZH2_27294783_Chip-Seq_ESCs_Mouse0.95136705
117NCOR_22424771_ChIP-Seq_293T_Human0.94810086
118ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94758326
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94746051
120ERG_21242973_ChIP-ChIP_JURKAT_Human0.94697821
121RNF2_27304074_Chip-Seq_NSC_Mouse0.94323063
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93820497
123* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93154610
124THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93097835
125PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92722350
126HTT_18923047_ChIP-ChIP_STHdh_Human0.92484966
127SOX2_21211035_ChIP-Seq_LN229_Human0.92456206
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92344553
129EED_16625203_ChIP-ChIP_MESCs_Mouse0.91821640
130* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91172548
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90101208
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89868475
133* FOXH1_21741376_ChIP-Seq_ESCs_Human0.88525422
134SOX2_22085726_ChIP-Seq_NPCs_Mouse0.88301281
135AR_21909140_ChIP-Seq_LNCAP_Human0.88249781
136MYC_18940864_ChIP-ChIP_HL60_Human0.87635702
137SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86996984
138AR_20517297_ChIP-Seq_VCAP_Human0.86596329
139IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86291729
140* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85955577
141KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85698616
142FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85532423
143ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84146046
144NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83977867
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83073789
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80846031
147* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.80559741
148RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80304251
149* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80155239
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79474193
151* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79309637
152LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78236456
153STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78029860
154* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77828389
155SPI1_23547873_ChIP-Seq_NB4_Human0.76513963
156THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75663374
157GATA2_22383799_ChIP-Seq_G1ME_Mouse0.74954261
158SCL_19346495_ChIP-Seq_HPC-7_Human0.74517813
159IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.74262645
160BCL6_27268052_Chip-Seq_Bcells_Human0.73979043
161POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73425255
162CTCF_18555785_ChIP-Seq_MESCs_Mouse0.73346862
163CTCF_26484167_Chip-Seq_Bcells_Mouse0.72580103
164VDR_21846776_ChIP-Seq_THP-1_Human0.70886909

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.13117913
2MP0005360_urolithiasis4.91646510
3MP0003806_abnormal_nucleotide_metabolis4.35681904
4MP0005085_abnormal_gallbladder_physiolo4.21930823
5MP0005365_abnormal_bile_salt4.03107276
6MP0008875_abnormal_xenobiotic_pharmacok3.41424067
7MP0003122_maternal_imprinting3.29895083
8MP0002837_dystrophic_cardiac_calcinosis2.85308053
9MP0003646_muscle_fatigue2.81775914
10MP0009840_abnormal_foam_cell2.72543788
11MP0006036_abnormal_mitochondrial_physio2.65884645
12MP0005332_abnormal_amino_acid2.64420656
13MP0003186_abnormal_redox_activity2.43730932
14MP0000566_synostosis2.41510029
15MP0010329_abnormal_lipoprotein_level2.39516848
16MP0003195_calcinosis2.37067254
17MP0003252_abnormal_bile_duct2.26568987
18MP0001529_abnormal_vocalization2.16991548
19MP0003191_abnormal_cellular_cholesterol2.14285417
20MP0004084_abnormal_cardiac_muscle2.13330931
21MP0005670_abnormal_white_adipose2.13125386
22MP0002822_catalepsy2.08395837
23MP0005083_abnormal_biliary_tract2.03814459
24MP0005330_cardiomyopathy2.00373285
25MP0005319_abnormal_enzyme/_coenzyme1.89473610
26MP0001764_abnormal_homeostasis1.81839835
27MP0001666_abnormal_nutrient_absorption1.78076015
28MP0000749_muscle_degeneration1.77080285
29MP0005451_abnormal_body_composition1.73746355
30MP0003123_paternal_imprinting1.73153818
31MP0002638_abnormal_pupillary_reflex1.72230138
32MP0002118_abnormal_lipid_homeostasis1.71515458
33MP0009643_abnormal_urine_homeostasis1.69167442
34MP0005584_abnormal_enzyme/coenzyme_acti1.67104234
35MP0005551_abnormal_eye_electrophysiolog1.65569570
36MP0000609_abnormal_liver_physiology1.65012791
37MP0004130_abnormal_muscle_cell1.63910698
38MP0004019_abnormal_vitamin_homeostasis1.62848677
39MP0004036_abnormal_muscle_relaxation1.61794006
40MP0003121_genomic_imprinting1.58164641
41MP0004142_abnormal_muscle_tone1.54513937
42MP0009046_muscle_twitch1.53592167
43MP0002938_white_spotting1.51785480
44MP0004215_abnormal_myocardial_fiber1.51024814
45MP0006035_abnormal_mitochondrial_morpho1.48609693
46MP0005423_abnormal_somatic_nervous1.43009000
47MP0004145_abnormal_muscle_electrophysio1.42286522
48MP0009697_abnormal_copulation1.37751856
49MP0001984_abnormal_olfaction1.36665122
50MP0003879_abnormal_hair_cell1.36605415
51MP0005666_abnormal_adipose_tissue1.36432731
52MP0001905_abnormal_dopamine_level1.34395903
53MP0003221_abnormal_cardiomyocyte_apopto1.33278871
54MP0003724_increased_susceptibility_to1.32830174
55MP0003136_yellow_coat_color1.28898495
56MP0002234_abnormal_pharynx_morphology1.28247380
57MP0000751_myopathy1.27354169
58MP0001544_abnormal_cardiovascular_syste1.26431622
59MP0005385_cardiovascular_system_phenoty1.26431622
60MP0003656_abnormal_erythrocyte_physiolo1.24715034
61MP0001853_heart_inflammation1.21564728
62MP0005266_abnormal_metabolism1.20595277
63MP0002557_abnormal_social/conspecific_i1.20015157
64MP0002972_abnormal_cardiac_muscle1.19709669
65MP0008775_abnormal_heart_ventricle1.18601585
66MP0006276_abnormal_autonomic_nervous1.18450084
67MP0005636_abnormal_mineral_homeostasis1.16622934
68MP0002064_seizures1.14903459
69MP0004147_increased_porphyrin_level1.13001807
70MP0002909_abnormal_adrenal_gland1.12761347
71MP0005058_abnormal_lysosome_morphology1.12092839
72MP0004087_abnormal_muscle_fiber1.11372313
73MP0005646_abnormal_pituitary_gland1.10012224
74MP0002138_abnormal_hepatobiliary_system1.09050849
75MP0002272_abnormal_nervous_system1.09010637
76MP0008872_abnormal_physiological_respon1.08333358
77MP0004133_heterotaxia1.08294955
78MP0008469_abnormal_protein_level1.08077054
79MP0000343_altered_response_to1.06186098
80MP0009745_abnormal_behavioral_response1.05939169
81MP0001756_abnormal_urination1.05674859
82MP0005448_abnormal_energy_balance1.05452450
83MP0005386_behavior/neurological_phenoty1.05387371
84MP0004924_abnormal_behavior1.05387371
85MP0000598_abnormal_liver_morphology1.05235861
86MP0002269_muscular_atrophy1.03656531
87MP0010630_abnormal_cardiac_muscle1.03256114
88MP0005376_homeostasis/metabolism_phenot1.02312026
89MP0005645_abnormal_hypothalamus_physiol1.00736622
90MP0002971_abnormal_brown_adipose0.98953375
91MP0009763_increased_sensitivity_to0.98733265
92MP0009379_abnormal_foot_pigmentation0.96867131
93MP0002735_abnormal_chemical_nociception0.96639289
94MP0001968_abnormal_touch/_nociception0.96539880
95MP0004043_abnormal_pH_regulation0.96208136
96MP0009764_decreased_sensitivity_to0.96192236
97MP0006138_congestive_heart_failure0.96136691
98MP0005377_hearing/vestibular/ear_phenot0.94774896
99MP0003878_abnormal_ear_physiology0.94774896
100MP0000750_abnormal_muscle_regeneration0.93260197
101MP0005167_abnormal_blood-brain_barrier0.92808609
102MP0003011_delayed_dark_adaptation0.92501189
103MP0009785_altered_susceptibility_to0.92031433
104MP0002572_abnormal_emotion/affect_behav0.91348405
105MP0006292_abnormal_olfactory_placode0.90089310
106MP0005620_abnormal_muscle_contractility0.89329524
107MP0004270_analgesia0.85482624
108MP0003953_abnormal_hormone_level0.84839136
109MP0004742_abnormal_vestibular_system0.83903604
110MP0003315_abnormal_perineum_morphology0.83636899
111MP0005535_abnormal_body_temperature0.83437280
112MP0003828_pulmonary_edema0.83131766
113MP0009642_abnormal_blood_homeostasis0.82942786
114MP0004858_abnormal_nervous_system0.82264704
115MP0005165_increased_susceptibility_to0.82123058
116MP0002067_abnormal_sensory_capabilities0.81645080
117MP0000372_irregular_coat_pigmentation0.80744272
118MP0005408_hypopigmentation0.79123909
119MP0002063_abnormal_learning/memory/cond0.78377086
120MP0002078_abnormal_glucose_homeostasis0.77962691
121MP0002736_abnormal_nociception_after0.77932039
122MP0000230_abnormal_systemic_arterial0.77845353
123MP0000955_abnormal_spinal_cord0.77483742
124MP0003868_abnormal_feces_composition0.75514841
125MP0003567_abnormal_fetal_cardiomyocyte0.73993343
126MP0002106_abnormal_muscle_physiology0.73835091
127MP0002102_abnormal_ear_morphology0.73482888
128MP0001661_extended_life_span0.72464145
129MP0003137_abnormal_impulse_conducting0.72347830
130MP0004782_abnormal_surfactant_physiolog0.72122807
131MP0003436_decreased_susceptibility_to0.72097490
132MP0002136_abnormal_kidney_physiology0.70949910
133MP0005334_abnormal_fat_pad0.70447532
134MP0003635_abnormal_synaptic_transmissio0.70243834
135MP0002229_neurodegeneration0.69173133
136MP0004185_abnormal_adipocyte_glucose0.69106541
137MP0002184_abnormal_innervation0.68792052
138MP0001486_abnormal_startle_reflex0.68602747
139MP0005025_abnormal_response_to0.68353769
140MP0010368_abnormal_lymphatic_system0.68042140
141MP0001970_abnormal_pain_threshold0.67589373
142MP0000538_abnormal_urinary_bladder0.67487697
143MP0005195_abnormal_posterior_eye0.66428162
144MP0001501_abnormal_sleep_pattern0.66422064
145MP0002876_abnormal_thyroid_physiology0.66411783
146MP0003880_abnormal_central_pattern0.66183589
147MP0005464_abnormal_platelet_physiology0.63778018
148MP0002332_abnormal_exercise_endurance0.62022905
149MP0003950_abnormal_plasma_membrane0.61590014
150MP0005084_abnormal_gallbladder_morpholo0.61480824
151MP0002132_abnormal_respiratory_system0.60433383
152MP0000747_muscle_weakness0.59947954
153MP0002970_abnormal_white_adipose0.59249918
154MP0001835_abnormal_antigen_presentation0.58987261
155MP0003693_abnormal_embryo_hatching0.58592450
156MP0005375_adipose_tissue_phenotype0.57749166
157MP0002419_abnormal_innate_immunity0.56282718
158MP0001845_abnormal_inflammatory_respons0.55735418

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.46463958
2* Hepatic necrosis (HP:0002605)4.33835854
3* Abnormality of fatty-acid metabolism (HP:0004359)4.33531685
4Hyperglycinuria (HP:0003108)4.23259082
5* Dicarboxylic aciduria (HP:0003215)4.20501054
6* Abnormality of dicarboxylic acid metabolism (HP:0010995)4.20501054
7Hyperammonemia (HP:0001987)4.15794569
8Cerebral edema (HP:0002181)3.93597410
9Ketosis (HP:0001946)3.88664452
10Hepatocellular necrosis (HP:0001404)3.85611243
11Abnormality of glycine metabolism (HP:0010895)3.85228146
12Abnormality of serine family amino acid metabolism (HP:0010894)3.85228146
13* Hypoglycemic coma (HP:0001325)3.80003341
14Acute encephalopathy (HP:0006846)3.78956553
15Intrahepatic cholestasis (HP:0001406)3.68957847
16Xanthomatosis (HP:0000991)3.58245373
17Increased muscle lipid content (HP:0009058)3.56660088
18Abnormality of monocarboxylic acid metabolism (HP:0010996)3.56268130
19Acute necrotizing encephalopathy (HP:0006965)3.55598842
20Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.55441555
21Abnormal mitochondria in muscle tissue (HP:0008316)3.52396048
22Ketoacidosis (HP:0001993)3.43714117
23Hyperglycinemia (HP:0002154)3.40348526
24Myoglobinuria (HP:0002913)3.38481754
25Mitochondrial inheritance (HP:0001427)3.36914821
26Hyperlipoproteinemia (HP:0010980)3.35054051
27Lethargy (HP:0001254)3.33131847
28Prolonged partial thromboplastin time (HP:0003645)3.31794953
29Hypobetalipoproteinemia (HP:0003563)3.29741244
30Increased CSF lactate (HP:0002490)3.26514486
31Rhabdomyolysis (HP:0003201)3.22488718
32* Generalized aminoaciduria (HP:0002909)3.14770831
33Lipid accumulation in hepatocytes (HP:0006561)3.12329253
34Deep venous thrombosis (HP:0002625)3.11709375
35Lactic acidosis (HP:0003128)3.09693295
36Abnormality of alanine metabolism (HP:0010916)3.08324593
37Hyperalaninemia (HP:0003348)3.08324593
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.08324593
39Increased intramyocellular lipid droplets (HP:0012240)3.06977267
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.97794805
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.97794805
42Metabolic acidosis (HP:0001942)2.97070855
43Ventricular tachycardia (HP:0004756)2.90583553
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.87314254
45Hypolipoproteinemia (HP:0010981)2.86397114
46Palpitations (HP:0001962)2.83366038
47Progressive macrocephaly (HP:0004481)2.80776980
48Abnormality of glutamine family amino acid metabolism (HP:0010902)2.78361197
49Abnormality of serum amino acid levels (HP:0003112)2.76449071
50Hypoalphalipoproteinemia (HP:0003233)2.76394157
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.72186509
52Increased serum lactate (HP:0002151)2.69210456
53* Vomiting (HP:0002013)2.64381303
54* Glycosuria (HP:0003076)2.63814552
55* Abnormality of urine glucose concentration (HP:0011016)2.63814552
56Abnormality of methionine metabolism (HP:0010901)2.62861024
57Abnormality of glycolysis (HP:0004366)2.60009253
58Increased serum pyruvate (HP:0003542)2.60009253
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59118613
60Abnormal number of erythroid precursors (HP:0012131)2.57756333
61* Nausea (HP:0002018)2.57666660
62Increased hepatocellular lipid droplets (HP:0006565)2.57198377
63Respiratory failure (HP:0002878)2.55825632
64Methylmalonic aciduria (HP:0012120)2.52170002
65Optic disc pallor (HP:0000543)2.51492296
66Multiple enchondromatosis (HP:0005701)2.49250622
67Lipoatrophy (HP:0100578)2.47869572
68* Proximal tubulopathy (HP:0000114)2.47626515
69Joint hemorrhage (HP:0005261)2.46392525
70Sudden death (HP:0001699)2.45733911
71Abnormality of sulfur amino acid metabolism (HP:0004339)2.45234055
72Exercise intolerance (HP:0003546)2.44019555
73Spontaneous abortion (HP:0005268)2.43702299
74Delayed CNS myelination (HP:0002188)2.43309965
75Hyperbilirubinemia (HP:0002904)2.43305319
76Abnormality of pyrimidine metabolism (HP:0004353)2.41434156
77Abnormality of cells of the erythroid lineage (HP:0012130)2.37406419
78Abnormality of the intrinsic pathway (HP:0010989)2.35625202
79Polyphagia (HP:0002591)2.33132079
80Abnormality of the common coagulation pathway (HP:0010990)2.32867735
81Hypothermia (HP:0002045)2.31756832
82Abnormality of complement system (HP:0005339)2.30690694
83Abnormality of nucleobase metabolism (HP:0010932)2.30601376
84Renal Fanconi syndrome (HP:0001994)2.30170107
85Glomerulonephritis (HP:0000099)2.25257204
86Dilated cardiomyopathy (HP:0001644)2.25246106
87Abnormality of purine metabolism (HP:0004352)2.25184986
88CNS demyelination (HP:0007305)2.22987778
89Complement deficiency (HP:0004431)2.22146647
90Gout (HP:0001997)2.20398723
91Ragged-red muscle fibers (HP:0003200)2.20262857
92Concave nail (HP:0001598)2.18348401
93Exercise-induced muscle cramps (HP:0003710)2.17594067
94Pancreatic cysts (HP:0001737)2.17241536
95Fat malabsorption (HP:0002630)2.16930967
963-Methylglutaconic aciduria (HP:0003535)2.11614350
97Hyperphosphaturia (HP:0003109)2.11084835
98Exercise-induced myalgia (HP:0003738)2.08810561
99Conjugated hyperbilirubinemia (HP:0002908)2.08257138
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06617439
101Lissencephaly (HP:0001339)2.04372717
102Conjunctival hamartoma (HP:0100780)2.03675641
103Epidermoid cyst (HP:0200040)2.02552840
104Pancreatitis (HP:0001733)2.00552078
105Abnormal cartilage morphology (HP:0002763)2.00490993
106Systemic lupus erythematosus (HP:0002725)1.99596634
107Late onset (HP:0003584)1.97685387
108Cerebral palsy (HP:0100021)1.97106063
109Emotional lability (HP:0000712)1.97092048
110X-linked dominant inheritance (HP:0001423)1.97068535
111Reduced antithrombin III activity (HP:0001976)1.96999633
112Neoplasm of head and neck (HP:0012288)1.96385522
113Esophageal neoplasm (HP:0100751)1.96385522
114Hypercholesterolemia (HP:0003124)1.95682052
115Right ventricular cardiomyopathy (HP:0011663)1.95452906
116Opisthotonus (HP:0002179)1.95039287
117True hermaphroditism (HP:0010459)1.94896075
118Hyperventilation (HP:0002883)1.94379137
119Hypertriglyceridemia (HP:0002155)1.90255697
120Type II lissencephaly (HP:0007260)1.90195638
121Severe muscular hypotonia (HP:0006829)1.89916812
122Leukodystrophy (HP:0002415)1.89602631
123Pancreatic fibrosis (HP:0100732)1.89570550
124Myokymia (HP:0002411)1.89416759
125Potter facies (HP:0002009)1.88797312
126Facial shape deformation (HP:0011334)1.88797312
127Calf muscle hypertrophy (HP:0008981)1.86009721
128Exertional dyspnea (HP:0002875)1.85977975
129Increased purine levels (HP:0004368)1.85230001
130Hemorrhage of the eye (HP:0011885)1.85024649
131Prominent supraorbital ridges (HP:0000336)1.82346273
132Enlarged kidneys (HP:0000105)1.79750020
133Methylmalonic acidemia (HP:0002912)1.75751041
134Congenital stationary night blindness (HP:0007642)1.73349279
135Medial flaring of the eyebrow (HP:0010747)1.72205476
136Macrocytic anemia (HP:0001972)1.70875328
137Oligomenorrhea (HP:0000876)1.70522088
138Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68331182
139Retinal atrophy (HP:0001105)1.67810322
140Reticulocytopenia (HP:0001896)1.67009026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.38027042
2MYLK3.36857598
3NME23.28442431
4MARK13.15197482
5FRK3.12687971
6STK163.00726235
7OBSCN2.61755436
8VRK22.51018735
9ERN12.35953487
10PDK42.07427470
11PDK32.07427470
12WNK32.04824319
13DYRK22.04050298
14KDR1.98255293
15FLT31.97576078
16MST1R1.94365864
17MAP2K71.94296426
18MAPK131.93553221
19MAP2K31.92104398
20TTN1.90275411
21MAP4K21.87140532
22PIK3CA1.85160564
23STK391.79542455
24TIE11.78709570
25EIF2AK31.76347669
26NEK11.70693520
27EIF2AK11.68140117
28IRAK31.63377468
29SIK21.62551786
30PKN21.62315612
31ADRBK21.56877120
32GRK11.56738573
33BMPR1B1.54519701
34MAP3K41.54367913
35LIMK11.53675555
36CASK1.52635524
37PIM21.52274674
38WEE11.52055795
39BUB11.51585079
40ABL21.45408377
41TRIB31.44725151
42ZAK1.41294954
43PINK11.39343533
44MUSK1.35244854
45LMTK21.29821707
46PRKCG1.26024744
47MAP3K31.25585951
48PIK3CG1.22202855
49CSNK1A1L1.21420430
50NEK91.21248940
51PDK21.19727620
52FGFR41.11721090
53ILK1.10299895
54CAMKK21.07841067
55CSNK1G31.07276308
56TYK21.07251693
57STK241.04947100
58SIK11.03472519
59EPHA40.99561307
60CAMK1D0.98982073
61EPHB20.98789950
62MAP2K40.98332887
63IRAK40.96884545
64TEC0.96862899
65STK38L0.95689225
66WNK40.95252774
67CSNK1G20.93220895
68AKT30.92988587
69CCNB10.92188984
70TBK10.91846429
71BLK0.90480762
72MAP3K110.89307711
73NTRK30.88608376
74ICK0.88254714
75DAPK20.88051074
76ADRBK10.87231808
77MAPK110.85880386
78STK40.85267889
79BRSK20.85152789
80VRK10.84545530
81KIT0.82137498
82DYRK1B0.81828747
83ACVR1B0.81284634
84TESK10.80480060
85LRRK20.79126749
86TGFBR20.76592800
87MAP4K10.76531649
88MAPKAPK30.75573791
89CSNK1G10.74060515
90BTK0.73857715
91PHKG20.73813054
92PHKG10.73813054
93NTRK20.73624007
94PAK30.73485157
95NME10.73388479
96MAPKAPK50.72892953
97MAP2K60.72741186
98TGFBR10.72623037
99TYRO30.72056775
100CAMK10.70098107
101PRKACA0.69875640
102TAOK30.69414841
103INSRR0.69225478
104EIF2AK20.67818732
105EPHA30.64174575
106CAMK2A0.63811006
107PRKCE0.63288961
108PRKCZ0.61875042
109RPS6KB20.60633591
110BCR0.59485074
111MINK10.59398008
112ZAP700.59351312
113DAPK30.58330291
114PRKAA20.57256403
115PBK0.57166518
116MAPK40.56301381
117CSNK1E0.56014028
118CDK40.55768828
119TRPM70.54621279
120PRKG20.53595938
121MAP2K20.53357079
122PRKACB0.52276583
123RPS6KA50.51649832
124TESK20.51501589
125GRK70.50996516
126CAMK40.50561140
127CAMK2B0.48701987
128RPS6KA60.48077744
129EPHA20.47755781
130MET0.47736657
131CSNK2A20.47632903
132RPS6KL10.46736088
133RPS6KC10.46736088
134PRKG10.46399705
135PKN10.46155662
136MAPK120.45485358
137DAPK10.45322861
138CAMK1G0.43721931
139CDK80.43489668
140TLK10.42582007
141CDK50.41912188
142MAP3K50.41678469
143CAMK2G0.41404339
144CSNK2A10.41127812
145AURKB0.41105067
146CSNK1A10.40369077
147PIM10.39178532
148JAK20.36812979
149MAP3K80.36049319
150IKBKB0.34598874
151CAMK2D0.34008075
152TAOK20.33237538
153SRPK10.32500026
154JAK30.32459058
155RPS6KA40.32255164
156DYRK30.32228113
157PLK40.31848002
158PRKAA10.31164891
159PRKCD0.30175864
160PRKACG0.29420427
161ARAF0.29163381

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.05764693
2Fatty acid degradation_Homo sapiens_hsa000712.94717758
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.93756732
4Propanoate metabolism_Homo sapiens_hsa006402.91410523
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.81836458
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68360771
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.54659671
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.28851469
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17257350
10Fatty acid metabolism_Homo sapiens_hsa012122.14283007
11Tryptophan metabolism_Homo sapiens_hsa003802.12620768
12Carbon metabolism_Homo sapiens_hsa012002.07044878
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.04906720
14Oxidative phosphorylation_Homo sapiens_hsa001902.04694731
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02762151
16Peroxisome_Homo sapiens_hsa041462.02460617
17Parkinsons disease_Homo sapiens_hsa050121.91093257
18Butanoate metabolism_Homo sapiens_hsa006501.91065010
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87307553
20Fatty acid elongation_Homo sapiens_hsa000621.84678665
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.82633915
22Pyruvate metabolism_Homo sapiens_hsa006201.82418730
23PPAR signaling pathway_Homo sapiens_hsa033201.72384315
24Arginine biosynthesis_Homo sapiens_hsa002201.70703889
25beta-Alanine metabolism_Homo sapiens_hsa004101.67868654
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64353219
27Folate biosynthesis_Homo sapiens_hsa007901.55999787
28Sulfur metabolism_Homo sapiens_hsa009201.50038895
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49337967
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.48685290
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.46842305
32Ribosome_Homo sapiens_hsa030101.46311489
33Biosynthesis of amino acids_Homo sapiens_hsa012301.46013352
34Proteasome_Homo sapiens_hsa030501.42526634
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37851765
36Chemical carcinogenesis_Homo sapiens_hsa052041.35940440
37Complement and coagulation cascades_Homo sapiens_hsa046101.34909232
38Histidine metabolism_Homo sapiens_hsa003401.33342382
39Nitrogen metabolism_Homo sapiens_hsa009101.32745987
40Caffeine metabolism_Homo sapiens_hsa002321.32437369
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29192525
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.28726991
43Phenylalanine metabolism_Homo sapiens_hsa003601.27662309
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24497679
45Selenocompound metabolism_Homo sapiens_hsa004501.23995622
46Starch and sucrose metabolism_Homo sapiens_hsa005001.22445181
47Alzheimers disease_Homo sapiens_hsa050101.19880624
48Sulfur relay system_Homo sapiens_hsa041221.19764263
49Pentose phosphate pathway_Homo sapiens_hsa000301.19440103
50Huntingtons disease_Homo sapiens_hsa050161.17687918
51Glutathione metabolism_Homo sapiens_hsa004801.17088948
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16868889
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13719809
54Tyrosine metabolism_Homo sapiens_hsa003501.11345520
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09018103
56Retinol metabolism_Homo sapiens_hsa008301.03214643
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.02853215
58Arginine and proline metabolism_Homo sapiens_hsa003301.01052313
59Fat digestion and absorption_Homo sapiens_hsa049750.91806980
60DNA replication_Homo sapiens_hsa030300.91084916
61Cardiac muscle contraction_Homo sapiens_hsa042600.89743478
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88288700
63One carbon pool by folate_Homo sapiens_hsa006700.88201087
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.86990270
65Staphylococcus aureus infection_Homo sapiens_hsa051500.83892468
66Protein export_Homo sapiens_hsa030600.82878588
67Galactose metabolism_Homo sapiens_hsa000520.82872334
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82770014
69Metabolic pathways_Homo sapiens_hsa011000.81778939
70Nicotine addiction_Homo sapiens_hsa050330.78931419
71Fructose and mannose metabolism_Homo sapiens_hsa000510.78435139
72Pyrimidine metabolism_Homo sapiens_hsa002400.74665099
73Phototransduction_Homo sapiens_hsa047440.70893776
74ABC transporters_Homo sapiens_hsa020100.65110591
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61065570
76Vitamin digestion and absorption_Homo sapiens_hsa049770.60948555
77Bile secretion_Homo sapiens_hsa049760.60854981
78Glycerolipid metabolism_Homo sapiens_hsa005610.57322616
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.51259383
80Mismatch repair_Homo sapiens_hsa034300.50419284
81Ether lipid metabolism_Homo sapiens_hsa005650.49029573
82Steroid biosynthesis_Homo sapiens_hsa001000.47971727
83Lysine degradation_Homo sapiens_hsa003100.45324835
84Mineral absorption_Homo sapiens_hsa049780.44880281
85RNA polymerase_Homo sapiens_hsa030200.43443506
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40317327
87Collecting duct acid secretion_Homo sapiens_hsa049660.39906734
88N-Glycan biosynthesis_Homo sapiens_hsa005100.37751078
89Arachidonic acid metabolism_Homo sapiens_hsa005900.37399301
90GABAergic synapse_Homo sapiens_hsa047270.36338384
91Vitamin B6 metabolism_Homo sapiens_hsa007500.35801872
92Homologous recombination_Homo sapiens_hsa034400.35182374
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33616104
94Base excision repair_Homo sapiens_hsa034100.32103628
95Fatty acid biosynthesis_Homo sapiens_hsa000610.31402531
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.30792221
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30726816
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30197427
99Other glycan degradation_Homo sapiens_hsa005110.29982809
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29596420
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29587800
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29412528
103Linoleic acid metabolism_Homo sapiens_hsa005910.28558550
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26650847
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25698465
106Taste transduction_Homo sapiens_hsa047420.25343468
107Purine metabolism_Homo sapiens_hsa002300.24413668
108Synaptic vesicle cycle_Homo sapiens_hsa047210.23042616
109Ovarian steroidogenesis_Homo sapiens_hsa049130.19474278
110Insulin resistance_Homo sapiens_hsa049310.18000174
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.16811836
112Nucleotide excision repair_Homo sapiens_hsa034200.16214921
113Legionellosis_Homo sapiens_hsa051340.14533381
114Renin-angiotensin system_Homo sapiens_hsa046140.13856193
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.08754928

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