ETFDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the electron-transfer system in mitochondria and is essential for electron transfer from a number of mitochondrial flavin-containing dehydrogenases to the main respiratory chain. Mutations in this gene are associated with glutaric acidemia. Alternatively spliced transcript variants that encode distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.94079233
2L-phenylalanine catabolic process (GO:0006559)5.94079233
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.76183196
4L-phenylalanine metabolic process (GO:0006558)5.76183196
5lysine metabolic process (GO:0006553)5.60795345
6lysine catabolic process (GO:0006554)5.60795345
7muscle filament sliding (GO:0030049)5.53554039
8actin-myosin filament sliding (GO:0033275)5.53554039
9aromatic amino acid family catabolic process (GO:0009074)5.39260744
10glyoxylate metabolic process (GO:0046487)5.30152965
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.19012746
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.19011040
13alpha-linolenic acid metabolic process (GO:0036109)5.12009487
14kynurenine metabolic process (GO:0070189)5.11319198
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.10387413
16* fatty acid beta-oxidation (GO:0006635)4.96150637
17indole-containing compound catabolic process (GO:0042436)4.95039862
18indolalkylamine catabolic process (GO:0046218)4.95039862
19tryptophan catabolic process (GO:0006569)4.95039862
20amino-acid betaine metabolic process (GO:0006577)4.84901295
21cellular ketone body metabolic process (GO:0046950)4.82819081
22fatty acid transmembrane transport (GO:1902001)4.78671061
23regulation of triglyceride catabolic process (GO:0010896)4.76860396
24bile acid biosynthetic process (GO:0006699)4.74495960
25actin-mediated cell contraction (GO:0070252)4.73589671
26tryptophan metabolic process (GO:0006568)4.68784792
27carnitine shuttle (GO:0006853)4.68225217
28exogenous drug catabolic process (GO:0042738)4.64345006
292-oxoglutarate metabolic process (GO:0006103)4.62775375
30* fatty acid oxidation (GO:0019395)4.58937551
31* lipid oxidation (GO:0034440)4.50271215
32acetyl-CoA metabolic process (GO:0006084)4.47325832
33* fatty acid catabolic process (GO:0009062)4.46901760
34regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.43611550
35sulfur amino acid catabolic process (GO:0000098)4.43581260
36urea metabolic process (GO:0019627)4.39380759
37urea cycle (GO:0000050)4.39380759
38cysteine metabolic process (GO:0006534)4.37731677
39homocysteine metabolic process (GO:0050667)4.36745581
40short-chain fatty acid metabolic process (GO:0046459)4.35902052
41regulation of sequestering of triglyceride (GO:0010889)4.33042480
42drug catabolic process (GO:0042737)4.32968456
43aspartate family amino acid catabolic process (GO:0009068)4.32585887
44carnitine metabolic process (GO:0009437)4.30926927
45sarcoplasmic reticulum calcium ion transport (GO:0070296)4.29647480
46serine family amino acid catabolic process (GO:0009071)4.21342869
47high-density lipoprotein particle remodeling (GO:0034375)4.20396678
48branched-chain amino acid catabolic process (GO:0009083)4.20024994
49* monocarboxylic acid catabolic process (GO:0072329)4.19957732
50heart contraction (GO:0060047)4.19073240
51heart process (GO:0003015)4.19073240
52tricarboxylic acid cycle (GO:0006099)4.17547717
53ketone body metabolic process (GO:1902224)4.17158000
54positive regulation of fatty acid beta-oxidation (GO:0032000)4.16713260
55complement activation, alternative pathway (GO:0006957)4.11714599
56negative regulation of fibrinolysis (GO:0051918)4.10867914
57alpha-amino acid catabolic process (GO:1901606)4.10281714
58valine metabolic process (GO:0006573)4.08658874
59epoxygenase P450 pathway (GO:0019373)4.07850408
60regulation of relaxation of muscle (GO:1901077)4.06781347
61peptidyl-glutamic acid carboxylation (GO:0017187)4.06658944
62protein carboxylation (GO:0018214)4.06658944
63nitrogen cycle metabolic process (GO:0071941)4.05750563
64triglyceride homeostasis (GO:0070328)4.05444688
65acylglycerol homeostasis (GO:0055090)4.05444688
66regulation of protein activation cascade (GO:2000257)4.04569763
67bile acid metabolic process (GO:0008206)4.04493295
68regulation of fibrinolysis (GO:0051917)3.96428175
69ethanol oxidation (GO:0006069)3.93804202
70sarcomere organization (GO:0045214)3.91242696
71aromatic amino acid family metabolic process (GO:0009072)3.90543144
72positive regulation of fatty acid oxidation (GO:0046321)3.89087302
73branched-chain amino acid metabolic process (GO:0009081)3.88693950
74cellular amino acid catabolic process (GO:0009063)3.85918269
75phospholipid homeostasis (GO:0055091)3.85495268
76regulation of fatty acid oxidation (GO:0046320)3.81537580
77* carboxylic acid catabolic process (GO:0046395)3.81138754
78* organic acid catabolic process (GO:0016054)3.81138754
79plasma lipoprotein particle clearance (GO:0034381)3.81109927
80biotin metabolic process (GO:0006768)3.80358458
81regulation of complement activation (GO:0030449)3.78725407
82myofibril assembly (GO:0030239)3.78081322
83positive regulation of lipid catabolic process (GO:0050996)3.74009953
84reverse cholesterol transport (GO:0043691)3.73586970
85protein-lipid complex remodeling (GO:0034368)3.72856213
86macromolecular complex remodeling (GO:0034367)3.72856213
87plasma lipoprotein particle remodeling (GO:0034369)3.72856213
88tyrosine metabolic process (GO:0006570)3.72122414
89coenzyme catabolic process (GO:0009109)3.71816669
90negative regulation of fatty acid biosynthetic process (GO:0045717)3.68945197
91regulation of cholesterol esterification (GO:0010872)3.68885037
92regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.67885277
93carnitine transmembrane transport (GO:1902603)3.66043125
94dicarboxylic acid biosynthetic process (GO:0043650)3.65956696
95S-adenosylmethionine metabolic process (GO:0046500)3.65675616
96response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.61269366
97detection of calcium ion (GO:0005513)3.58885468
98phospholipid efflux (GO:0033700)3.58707245
99carnitine transport (GO:0015879)3.58292651
100amino-acid betaine transport (GO:0015838)3.58292651
101cardiac myofibril assembly (GO:0055003)3.54528058
102cellular glucuronidation (GO:0052695)3.53753934
103negative regulation of lipase activity (GO:0060192)3.49954062
104omega-hydroxylase P450 pathway (GO:0097267)3.48405348
105indolalkylamine metabolic process (GO:0006586)3.47675390
106regulation of cholesterol metabolic process (GO:0090181)3.47500578
107xenobiotic catabolic process (GO:0042178)3.47498963
108NADH metabolic process (GO:0006734)3.45219100
109cellular modified amino acid catabolic process (GO:0042219)3.44823409
110regulation of skeletal muscle contraction (GO:0014819)3.43524121
111oxidative demethylation (GO:0070989)3.43142307
112tricarboxylic acid metabolic process (GO:0072350)3.42823821
113regulation of fatty acid beta-oxidation (GO:0031998)3.42607232
114benzene-containing compound metabolic process (GO:0042537)3.40065752
115glutamate metabolic process (GO:0006536)3.39504219
116regulation of cell communication by electrical coupling (GO:0010649)3.37417940
117amine catabolic process (GO:0009310)3.36004309
118cellular biogenic amine catabolic process (GO:0042402)3.36004309
119succinate metabolic process (GO:0006105)3.34756093
120bile acid and bile salt transport (GO:0015721)3.34650718
121regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.33340321
122negative regulation of sterol transport (GO:0032372)3.31906972
123negative regulation of cholesterol transport (GO:0032375)3.31906972
124cardiac muscle contraction (GO:0060048)3.30528989
125regulation of actin filament-based movement (GO:1903115)3.29029342
126regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.28494935
127glycine metabolic process (GO:0006544)3.28339925
128regulation of hexokinase activity (GO:1903299)3.28102280
129regulation of glucokinase activity (GO:0033131)3.28102280
130acyl-CoA metabolic process (GO:0006637)3.26143947
131drug metabolic process (GO:0017144)3.18346307
132actin filament-based movement (GO:0030048)3.18235963
133glucuronate metabolic process (GO:0019585)3.16772977
134uronic acid metabolic process (GO:0006063)3.16772977
135striated muscle contraction (GO:0006941)3.14473606
136oxaloacetate metabolic process (GO:0006107)3.14138076
137actomyosin structure organization (GO:0031032)3.10965510
138amino acid salvage (GO:0043102)3.10514044
139L-methionine salvage (GO:0071267)3.10514044
140L-methionine biosynthetic process (GO:0071265)3.10514044
141regulation of striated muscle contraction (GO:0006942)3.09568832
142creatine metabolic process (GO:0006600)3.03210450
143regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.97230058
144phenylpropanoid metabolic process (GO:0009698)2.90456463
145cardiac muscle hypertrophy (GO:0003300)2.88271284
146cardiac muscle tissue morphogenesis (GO:0055008)2.86735148
147negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.85342828
148regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.82922721
149ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.82738754
150quinone biosynthetic process (GO:1901663)2.80860086
151regulation of acyl-CoA biosynthetic process (GO:0050812)2.80590177
152positive regulation of glycolytic process (GO:0045821)2.79801664
153glycogen catabolic process (GO:0005980)2.77618024
154macroautophagy (GO:0016236)2.75112640
155striated muscle hypertrophy (GO:0014897)2.74252139
156peroxisome fission (GO:0016559)2.73207533
157regulation of type B pancreatic cell apoptotic process (GO:2000674)2.69532715
158water-soluble vitamin biosynthetic process (GO:0042364)2.68652064
159quaternary ammonium group transport (GO:0015697)2.68427697
160C4-dicarboxylate transport (GO:0015740)2.66302855
161lipid particle organization (GO:0034389)2.63668769
162glucan catabolic process (GO:0009251)2.63203910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.21345545
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.18660564
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.27605786
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.77037054
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.54448332
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.65744102
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.99691279
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.90344195
9* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.57725071
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.89113417
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.83254557
12IGF1R_20145208_ChIP-Seq_DFB_Human2.71063005
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.66839437
14VDR_22108803_ChIP-Seq_LS180_Human2.52091316
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45839968
16GBX2_23144817_ChIP-Seq_PC3_Human2.36176937
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33732816
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27536810
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.23239109
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19929927
21ZNF274_21170338_ChIP-Seq_K562_Hela2.03892323
22CLOCK_20551151_ChIP-Seq_293T_Human2.02793293
23GATA1_22025678_ChIP-Seq_K562_Human2.00723191
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2560934
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98167952
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96718282
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.90563578
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.89873889
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.86022161
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.84701093
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.83345446
32* FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77003478
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.75615554
34FUS_26573619_Chip-Seq_HEK293_Human1.71316951
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67877938
36TAF15_26573619_Chip-Seq_HEK293_Human1.63957072
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63448909
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.60615242
39ER_23166858_ChIP-Seq_MCF-7_Human1.59708798
40P300_19829295_ChIP-Seq_ESCs_Human1.55543641
41EZH2_22144423_ChIP-Seq_EOC_Human1.54667663
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52879618
43CRX_20693478_ChIP-Seq_RETINA_Mouse1.49095190
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47933166
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.47737139
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47329071
47TBX20_22328084_ChIP-Seq_HEART_Mouse1.44516926
48TBX20_22080862_ChIP-Seq_HEART_Mouse1.44516926
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44402071
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44371110
51SMAD4_21799915_ChIP-Seq_A2780_Human1.44287029
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40900840
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.39719593
54NANOG_19829295_ChIP-Seq_ESCs_Human1.38795196
55SOX2_19829295_ChIP-Seq_ESCs_Human1.38795196
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38512210
57P53_22387025_ChIP-Seq_ESCs_Mouse1.36859591
58* STAT3_23295773_ChIP-Seq_U87_Human1.35926226
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.35636848
60* TCF4_23295773_ChIP-Seq_U87_Human1.33377265
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31953445
62CBP_20019798_ChIP-Seq_JUKART_Human1.31531508
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31531508
64OCT4_21477851_ChIP-Seq_ESCs_Mouse1.31061175
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30480520
66STAT3_18555785_Chip-Seq_ESCs_Mouse1.30407599
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30076236
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29845232
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29567931
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.28906673
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28356940
72* HNF4A_19822575_ChIP-Seq_HepG2_Human1.28334474
73HTT_18923047_ChIP-ChIP_STHdh_Human1.27385571
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25906515
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25823403
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25479005
77PHF8_20622853_ChIP-Seq_HELA_Human1.25352958
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24443908
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22621745
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21793069
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21265397
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.20190390
83TP53_22573176_ChIP-Seq_HFKS_Human1.19029906
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18682899
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18670252
86AR_25329375_ChIP-Seq_VCAP_Human1.18001816
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17271184
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16859315
89SOX2_18555785_Chip-Seq_ESCs_Mouse1.16147871
90HNFA_21074721_ChIP-Seq_CACO-2_Human1.15607936
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15279706
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14359816
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14089994
94NFYB_21822215_ChIP-Seq_K562_Human1.13010793
95P300_18555785_Chip-Seq_ESCs_Mouse1.12902108
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.12862767
97ZNF263_19887448_ChIP-Seq_K562_Human1.12148442
98CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.11393080
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10919401
100OCT4_18555785_Chip-Seq_ESCs_Mouse1.10855000
101CTCF_18555785_Chip-Seq_ESCs_Mouse1.10801322
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10102894
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.09912363
104ETV1_20927104_ChIP-Seq_GIST48_Human1.09356784
105PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09159515
106NFYA_21822215_ChIP-Seq_K562_Human1.08977554
107TCF4_22108803_ChIP-Seq_LS180_Human1.08798068
108PU1_27457419_Chip-Seq_LIVER_Mouse1.07399140
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05109062
110* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02340205
111* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95636235
112SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94823926
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92890472
114AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91901455
115* GATA4_25053715_ChIP-Seq_YYC3_Human0.90170493
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89116294
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89116294
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87023596
119ESR2_21235772_ChIP-Seq_MCF-7_Human0.87009805
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85456421
121PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82700098
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81967130
123IRF8_22096565_ChIP-ChIP_GC-B_Human0.80526765
124RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79135236
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79025412
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76066969
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.74755541
128BCAT_22108803_ChIP-Seq_LS180_Human0.74254713
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73469265
130GATA4_21415370_ChIP-Seq_HL-1_Mouse0.72693785
131* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.71651059
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69871514
133* GATA2_21666600_ChIP-Seq_HMVEC_Human0.69010885
134FOXO3_23340844_ChIP-Seq_DLD1_Human0.68631717
135CEBPB_22108803_ChIP-Seq_LS180_Human0.68593258
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.67315623
137EGR1_19032775_ChIP-ChIP_M12_Human0.67216519
138GATA2_19941826_ChIP-Seq_K562_Human0.66501295
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.64455887
140AR_20517297_ChIP-Seq_VCAP_Human0.62950819
141GATA1_19941826_ChIP-Seq_K562_Human0.61920582
142FOXA1_25552417_ChIP-Seq_VCAP_Human0.61393275
143CBP_21632823_ChIP-Seq_H3396_Human0.61373319
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.61000732
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.60851131
146NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.60542907
147FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60542030
148BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58571487
149CDX2_22108803_ChIP-Seq_LS180_Human0.57812223
150FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.57100354
151MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.56243748
152ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.56029599
153STAT3_1855785_ChIP-Seq_MESCs_Mouse0.55902697
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55244551
155GATA1_19941827_ChIP-Seq_MEL_Mouse0.54949488
156KAP1_22055183_ChIP-Seq_ESCs_Mouse0.53789724
157RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53770772
158RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.53405636
159ESET_19884257_ChIP-Seq_ESCs_Mouse0.50142676
160STAT1_17558387_ChIP-Seq_HELA_Human0.50038850
161NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.50001977
162CDX2_20551321_ChIP-Seq_CACO-2_Human0.49957161
163LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.49867441
164ERG_20517297_ChIP-Seq_VCAP_Human0.49330109
165CJUN_26792858_Chip-Seq_BT549_Human0.48725148
166SOX9_24532713_ChIP-Seq_HFSC_Mouse0.46962712
167SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.46837393
168* GATA3_24758297_ChIP-Seq_MCF-7_Human0.46426353
169SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.46004382
170SOX2_20726797_ChIP-Seq_SW620_Human0.45484867
171TAF2_19829295_ChIP-Seq_ESCs_Human0.45306214
172TRIM28_21343339_ChIP-Seq_HEK293_Human0.45162624
173CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.44993101
174PIAS1_25552417_ChIP-Seq_VCAP_Human0.44655746
175GATA6_25053715_ChIP-Seq_YYC3_Human0.44110579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.52641459
2MP0005360_urolithiasis5.98357817
3MP0005085_abnormal_gallbladder_physiolo5.35463343
4MP0005365_abnormal_bile_salt5.16521762
5MP0008875_abnormal_xenobiotic_pharmacok3.87505785
6MP0003806_abnormal_nucleotide_metabolis3.50213467
7MP0002837_dystrophic_cardiac_calcinosis3.46272605
8MP0003252_abnormal_bile_duct3.29252817
9MP0004145_abnormal_muscle_electrophysio3.12981847
10MP0010329_abnormal_lipoprotein_level3.05118663
11MP0005332_abnormal_amino_acid2.66960957
12MP0003195_calcinosis2.61728493
13MP0003646_muscle_fatigue2.55526342
14MP0009840_abnormal_foam_cell2.46575702
15MP0004130_abnormal_muscle_cell2.31266746
16MP0005670_abnormal_white_adipose2.29167325
17MP0005083_abnormal_biliary_tract2.27178435
18MP0001666_abnormal_nutrient_absorption2.14324118
19MP0002118_abnormal_lipid_homeostasis2.06328014
20MP0004084_abnormal_cardiac_muscle2.04963357
21MP0003191_abnormal_cellular_cholesterol2.03558433
22MP0005330_cardiomyopathy1.99278226
23MP0000609_abnormal_liver_physiology1.90720098
24MP0004215_abnormal_myocardial_fiber1.90630722
25MP0005319_abnormal_enzyme/_coenzyme1.83056906
26MP0006036_abnormal_mitochondrial_physio1.80237841
27MP0005666_abnormal_adipose_tissue1.75341128
28MP0005451_abnormal_body_composition1.71631087
29MP0004019_abnormal_vitamin_homeostasis1.67970225
30MP0004036_abnormal_muscle_relaxation1.65010049
31MP0002138_abnormal_hepatobiliary_system1.64418367
32MP0000751_myopathy1.62258549
33MP0000013_abnormal_adipose_tissue1.60959697
34MP0005584_abnormal_enzyme/coenzyme_acti1.56991382
35MP0004510_myositis1.51301807
36MP0000749_muscle_degeneration1.42370797
37MP0002638_abnormal_pupillary_reflex1.40395528
38MP0002971_abnormal_brown_adipose1.39895498
39MP0008775_abnormal_heart_ventricle1.37074563
40MP0001764_abnormal_homeostasis1.35125787
41MP0009643_abnormal_urine_homeostasis1.34116112
42MP0009697_abnormal_copulation1.33222155
43MP0003186_abnormal_redox_activity1.30582129
44MP0002972_abnormal_cardiac_muscle1.29910391
45MP0009780_abnormal_chondrocyte_physiolo1.29897951
46MP0004087_abnormal_muscle_fiber1.27902612
47MP0003868_abnormal_feces_composition1.25689801
48MP0005385_cardiovascular_system_phenoty1.23736278
49MP0001544_abnormal_cardiovascular_syste1.23736278
50MP0010368_abnormal_lymphatic_system1.20195304
51MP0002269_muscular_atrophy1.15861473
52MP0005379_endocrine/exocrine_gland_phen1.15731945
53MP0010630_abnormal_cardiac_muscle1.13703454
54MP0005620_abnormal_muscle_contractility1.11638655
55MP0006138_congestive_heart_failure1.09808620
56MP0005645_abnormal_hypothalamus_physiol1.09509525
57MP0002909_abnormal_adrenal_gland1.08318086
58MP0003705_abnormal_hypodermis_morpholog1.06012744
59MP0005535_abnormal_body_temperature1.06002357
60MP0002078_abnormal_glucose_homeostasis1.05965174
61MP0003011_delayed_dark_adaptation1.04505323
62MP0005551_abnormal_eye_electrophysiolog1.03730045
63MP0006072_abnormal_retinal_apoptosis1.02632838
64MP0003221_abnormal_cardiomyocyte_apopto1.00807077
65MP0001984_abnormal_olfaction0.99095935
66MP0006035_abnormal_mitochondrial_morpho0.98755019
67MP0005334_abnormal_fat_pad0.98575796
68MP0003137_abnormal_impulse_conducting0.97792226
69MP0003656_abnormal_erythrocyte_physiolo0.96573166
70MP0000598_abnormal_liver_morphology0.95601503
71MP0004185_abnormal_adipocyte_glucose0.95156418
72MP0005375_adipose_tissue_phenotype0.94963958
73MP0009763_increased_sensitivity_to0.92096434
74MP0005646_abnormal_pituitary_gland0.90980519
75MP0004484_altered_response_of0.90439842
76MP0005266_abnormal_metabolism0.90157891
77MP0005647_abnormal_sex_gland0.88541193
78MP0009764_decreased_sensitivity_to0.87875864
79MP0000372_irregular_coat_pigmentation0.81097452
80MP0001501_abnormal_sleep_pattern0.80030936
81MP0004043_abnormal_pH_regulation0.79977643
82MP0005253_abnormal_eye_physiology0.79681945
83MP0009642_abnormal_blood_homeostasis0.79282328
84MP0002106_abnormal_muscle_physiology0.77754056
85MP0004142_abnormal_muscle_tone0.77638340
86MP0005636_abnormal_mineral_homeostasis0.77153863
87MP0001661_extended_life_span0.75319228
88MP0004085_abnormal_heartbeat0.75244821
89MP0000750_abnormal_muscle_regeneration0.74972620
90MP0009115_abnormal_fat_cell0.74292141
91MP0000230_abnormal_systemic_arterial0.74171528
92MP0005376_homeostasis/metabolism_phenot0.74078495
93MP0008877_abnormal_DNA_methylation0.73159133
94MP0002332_abnormal_exercise_endurance0.73003754
95MP0008469_abnormal_protein_level0.72113663
96MP0001756_abnormal_urination0.72012370
97MP0002693_abnormal_pancreas_physiology0.71561498
98MP0000003_abnormal_adipose_tissue0.69415509
99MP0002102_abnormal_ear_morphology0.69360576
100MP0000747_muscle_weakness0.69104572
101MP0003950_abnormal_plasma_membrane0.68867289
102MP0000538_abnormal_urinary_bladder0.68814576
103MP0005448_abnormal_energy_balance0.68046347
104MP0004147_increased_porphyrin_level0.67655929
105MP0002254_reproductive_system_inflammat0.66899897
106MP0003828_pulmonary_edema0.66239895
107MP0005165_increased_susceptibility_to0.65824044
108MP0001944_abnormal_pancreas_morphology0.64751784
109MP0002876_abnormal_thyroid_physiology0.64508857
110MP0002127_abnormal_cardiovascular_syste0.63066345
111MP0002970_abnormal_white_adipose0.61339472
112MP0010386_abnormal_urinary_bladder0.61253489
113MP0005369_muscle_phenotype0.60384708
114MP0000759_abnormal_skeletal_muscle0.60251042
115MP0005084_abnormal_gallbladder_morpholo0.59900367
116MP0001765_abnormal_ion_homeostasis0.59068614
117MP0000343_altered_response_to0.59011377
118MP0001853_heart_inflammation0.52152271
119MP0000604_amyloidosis0.51852981
120MP0009384_cardiac_valve_regurgitation0.51586752
121MP0002136_abnormal_kidney_physiology0.48795059
122MP0003953_abnormal_hormone_level0.48504487
123MP0003724_increased_susceptibility_to0.46732569
124MP0002128_abnormal_blood_circulation0.43288590
125MP0005408_hypopigmentation0.41273054

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.30658064
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.11438721
3Deep venous thrombosis (HP:0002625)5.02330722
4Xanthomatosis (HP:0000991)4.79663712
5Hyperammonemia (HP:0001987)4.79514146
6Ketosis (HP:0001946)4.67827958
7Hyperglycinuria (HP:0003108)4.66984004
8* Hypoglycemic coma (HP:0001325)4.61241898
9Muscle fiber inclusion bodies (HP:0100299)4.50985619
10* Abnormality of fatty-acid metabolism (HP:0004359)4.48893525
11Abnormality of monocarboxylic acid metabolism (HP:0010996)4.41188301
12Prolonged partial thromboplastin time (HP:0003645)4.35522963
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.32399197
14Hypobetalipoproteinemia (HP:0003563)4.31088991
15Hyperlipoproteinemia (HP:0010980)4.30606142
16Ketoacidosis (HP:0001993)4.29922420
17Nemaline bodies (HP:0003798)4.27912250
18Abnormality of serine family amino acid metabolism (HP:0010894)4.27834692
19Abnormality of glycine metabolism (HP:0010895)4.27834692
20Hypoalphalipoproteinemia (HP:0003233)4.06014206
21Hyperglycinemia (HP:0002154)4.03861738
22* Abnormality of dicarboxylic acid metabolism (HP:0010995)3.98041565
23* Dicarboxylic aciduria (HP:0003215)3.98041565
24Hypolipoproteinemia (HP:0010981)3.94966976
25Myoglobinuria (HP:0002913)3.94311275
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.88270271
27Bundle branch block (HP:0011710)3.82107052
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.68145758
29Complement deficiency (HP:0004431)3.66292648
30Epidermoid cyst (HP:0200040)3.56765920
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.50274408
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.42745210
33Cerebral edema (HP:0002181)3.35216945
34Sudden death (HP:0001699)3.33649372
35Abnormality of the calf musculature (HP:0001430)3.29918152
36Joint hemorrhage (HP:0005261)3.26183158
37Abnormality of methionine metabolism (HP:0010901)3.23698784
38Rhabdomyolysis (HP:0003201)3.23423183
39EMG: myopathic abnormalities (HP:0003458)3.22360788
40Metabolic acidosis (HP:0001942)3.20423428
41Abnormality of sulfur amino acid metabolism (HP:0004339)3.18271597
42Abnormality of serum amino acid levels (HP:0003112)3.11305985
43Abnormality of the common coagulation pathway (HP:0010990)3.07054572
44Ventricular tachycardia (HP:0004756)3.06682279
45Lethargy (HP:0001254)3.05201789
46Exercise-induced myalgia (HP:0003738)3.01547673
47Right ventricular cardiomyopathy (HP:0011663)2.97009707
48Type 1 muscle fiber predominance (HP:0003803)2.89624559
49Fat malabsorption (HP:0002630)2.85482855
50Rimmed vacuoles (HP:0003805)2.84197723
51Tongue fasciculations (HP:0001308)2.78663165
52Abnormality of the intrinsic pathway (HP:0010989)2.74737216
53Hypercholesterolemia (HP:0003124)2.73968188
54Palpitations (HP:0001962)2.71789293
55Hyperbilirubinemia (HP:0002904)2.70183342
56Skin nodule (HP:0200036)2.69379222
57Abnormality of purine metabolism (HP:0004352)2.67562977
58Exercise-induced muscle cramps (HP:0003710)2.61226147
59Hypoglycemic seizures (HP:0002173)2.59874539
60Hyperinsulinemic hypoglycemia (HP:0000825)2.58981776
61Abnormality of nucleobase metabolism (HP:0010932)2.57518451
62Conjugated hyperbilirubinemia (HP:0002908)2.56321063
63* Hepatic necrosis (HP:0002605)2.55043371
64Congenital stationary night blindness (HP:0007642)2.54495013
65Increased muscle lipid content (HP:0009058)2.52851229
66Lipoatrophy (HP:0100578)2.50920766
67Ventricular arrhythmia (HP:0004308)2.50739286
68Abnormality of complement system (HP:0005339)2.49638843
69Delayed CNS myelination (HP:0002188)2.49125440
70Muscle fibrillation (HP:0010546)2.48952173
71Acute necrotizing encephalopathy (HP:0006965)2.48170065
72* Vomiting (HP:0002013)2.47359213
73* Generalized aminoaciduria (HP:0002909)2.46330091
74Calf muscle hypertrophy (HP:0008981)2.39104679
75Acute encephalopathy (HP:0006846)2.38838758
76Gout (HP:0001997)2.37902397
77Abnormality of pyrimidine metabolism (HP:0004353)2.37429400
78Dilated cardiomyopathy (HP:0001644)2.37387180
79Cholelithiasis (HP:0001081)2.35811633
80Progressive macrocephaly (HP:0004481)2.34619573
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33456587
82Abnormality of alanine metabolism (HP:0010916)2.33456587
83Hyperalaninemia (HP:0003348)2.33456587
84Frequent falls (HP:0002359)2.33344137
85Hyperglycemia (HP:0003074)2.32950260
86Atrial fibrillation (HP:0005110)2.31240854
87Reduced antithrombin III activity (HP:0001976)2.31205703
88Abnormal gallbladder morphology (HP:0012437)2.30591385
89Increased CSF lactate (HP:0002490)2.30285098
90Hypothermia (HP:0002045)2.29204682
91Hepatocellular necrosis (HP:0001404)2.28346982
92Neck muscle weakness (HP:0000467)2.27937040
93Abnormality of vitamin B metabolism (HP:0004340)2.27690296
94Myocardial infarction (HP:0001658)2.26824856
95Abnormality of vitamin metabolism (HP:0100508)2.26716017
96* Abnormality of urine glucose concentration (HP:0011016)2.26469003
97* Glycosuria (HP:0003076)2.26469003
98Abnormal atrioventricular conduction (HP:0005150)2.26388571
99Hepatocellular carcinoma (HP:0001402)2.25529265
100Abnormal mitochondria in muscle tissue (HP:0008316)2.22999826
101Mitochondrial inheritance (HP:0001427)2.22124251
102Atrioventricular block (HP:0001678)2.21553872
103Vascular calcification (HP:0004934)2.17209138
104Hyporeflexia of lower limbs (HP:0002600)2.16806667
105Hyperuricemia (HP:0002149)2.16418220
106Increased purine levels (HP:0004368)2.16418220
107* Renal cortical cysts (HP:0000803)2.16323179
108* Proximal tubulopathy (HP:0000114)2.15219502
109Syncope (HP:0001279)2.14164295
110Methylmalonic aciduria (HP:0012120)2.11493874
111Muscle hypertrophy of the lower extremities (HP:0008968)2.11272362
112Hydroxyprolinuria (HP:0003080)2.11187979
113Abnormality of proline metabolism (HP:0010907)2.11187979
114Late onset (HP:0003584)2.08108410
115Lactic acidosis (HP:0003128)2.07305885
116Methylmalonic acidemia (HP:0002912)2.06665715
117Primary atrial arrhythmia (HP:0001692)2.06207962
118Prolonged QT interval (HP:0001657)2.05558105
119Steatorrhea (HP:0002570)2.04843820
120Left ventricular hypertrophy (HP:0001712)2.04237165
121Asymmetric septal hypertrophy (HP:0001670)2.04045464
122Pancreatitis (HP:0001733)2.03808288
123Subaortic stenosis (HP:0001682)2.03620108
124Abnormality of the left ventricular outflow tract (HP:0011103)2.03620108
125Heart block (HP:0012722)2.02532593
126* Nausea (HP:0002018)2.01789971
127Increased serum pyruvate (HP:0003542)2.01437761
128Abnormality of glycolysis (HP:0004366)2.01437761
129EMG: neuropathic changes (HP:0003445)2.00866498
130Muscle fiber splitting (HP:0003555)2.00361024
131Ragged-red muscle fibers (HP:0003200)1.99491839
132Cardiovascular calcification (HP:0011915)1.99334062
133Hypoplasia of the fovea (HP:0007750)1.99098252
134Aplasia/Hypoplasia of the fovea (HP:0008060)1.99098252
135Sensorimotor neuropathy (HP:0007141)1.98636947
136Supraventricular tachycardia (HP:0004755)1.95431198
137Exercise intolerance (HP:0003546)1.93495064
138Hypertriglyceridemia (HP:0002155)1.93019530
139Severe muscular hypotonia (HP:0006829)1.92531908
140Supraventricular arrhythmia (HP:0005115)1.91156845
141Abnormal rod and cone electroretinograms (HP:0008323)1.90749230
142Facial diplegia (HP:0001349)1.89769381
143Large for gestational age (HP:0001520)1.87888989
144Central scotoma (HP:0000603)1.85409251
145* Abnormality of the renal cortex (HP:0011035)1.84101317

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.07912228
2PDK43.14805322
3PDK33.14805322
4INSRR3.05644325
5TTN3.02884857
6SIK12.96758096
7OBSCN2.68845318
8BMPR1B2.66851643
9TRIB32.64247130
10PKN22.60934677
11FGFR42.45977849
12LMTK22.29645610
13TIE12.21500390
14MYLK2.12167785
15GRK12.11469806
16ACVR1B2.04415146
17PDK21.91823611
18PHKG11.91559492
19PHKG21.91559492
20WNK31.91150942
21ERN11.90862320
22ADRBK21.88093005
23PINK11.84727143
24MAP4K21.75931010
25PIK3CA1.72928515
26FLT31.70902783
27NEK91.67644636
28STK38L1.65041746
29PRKAA21.57140116
30MAP2K31.52744306
31LATS11.48807488
32PIK3CG1.47802985
33CAMK1D1.39272711
34CDC42BPA1.35481658
35ERBB31.31677489
36PRKCE1.23778824
37MAP3K71.23644735
38NEK11.21172880
39MST1R1.21111619
40MAP2K41.21037005
41AKT31.17005294
42TAOK31.16535402
43ERBB41.15187909
44MAPK111.14685156
45STK241.14605588
46PRKAA11.12724705
47FRK1.12655981
48STK391.12642033
49OXSR11.12558089
50DAPK21.07909896
51MAP3K41.05494977
52PTK61.00547714
53KDR1.00112763
54TYK20.97181531
55EIF2AK30.93758034
56MAPK120.91340836
57MST40.91140204
58JAK10.89618459
59GRK70.89168230
60MAP3K50.87527636
61DMPK0.86944119
62ZAK0.86768099
63CAMKK20.86536143
64MAP3K60.86366689
65CAMK2A0.85948866
66MAP3K30.84776361
67WNK40.84488824
68FER0.84017010
69PRKG10.83426379
70DAPK30.83267685
71LIMK10.82609480
72TGFBR20.82158678
73MAPK130.81935170
74PRKD10.80281299
75RIPK10.79930994
76PAK30.76347860
77SGK30.74581576
78ABL20.70383637
79JAK20.69796359
80SGK20.69690591
81PRKACG0.69096484
82MUSK0.68831102
83MAP2K60.67788665
84CAMK40.66787579
85CAMK1G0.66696226
86CSNK1G10.62792487
87TRPM70.61392026
88FGFR20.60329087
89BRSK20.58772155
90IRAK30.58559914
91EPHA30.57847812
92TBK10.56843214
93PKN10.56759994
94STK40.56317123
95CSNK1G30.56012273
96FGFR30.55152543
97PRKG20.55093929
98PDPK10.54542921
99CAMK2D0.53800492
100EPHB10.52887983
101NME10.51918585
102NTRK30.51789708
103PTK2B0.51143701
104NLK0.48752309
105PNCK0.48244142
106MAP3K140.48156042
107CSNK1G20.47918509
108CAMK2G0.47086894
109ADRBK10.46602881
110SGK2230.44420678
111SGK4940.44420678
112MAPK40.44212767
113PRKCG0.41897890
114TGFBR10.41828319
115CASK0.40508759
116PRKCQ0.40458445
117PDK10.40076958
118PDGFRA0.39980618
119TNK20.39553416
120GSK3A0.39079209
121MAPKAPK30.38886157
122NUAK10.37412406
123TEC0.36921591
124CSNK1A1L0.36260134
125STK380.34657415
126TNIK0.34160213
127ROCK10.33954352
128PRKACA0.33859357
129RET0.33388704
130CAMK10.33356308
131PRKCH0.33242295
132IKBKE0.33063808
133NME20.33043643
134PRKCA0.32775824
135RPS6KB10.32287828
136MKNK20.31915943
137STK30.31609215
138IGF1R0.31304199
139PRKACB0.30698557
140MAPK70.30112293
141PLK40.30007292
142ITK0.29860832
143MAP2K10.29816111
144ERBB20.28800306
145AKT20.28642330
146CDK60.28062239
147ILK0.27835919

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000713.50044648
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.46633220
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27200243
4Propanoate metabolism_Homo sapiens_hsa006403.27112262
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.21274488
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.81992845
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.77138090
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.70863804
9Fatty acid metabolism_Homo sapiens_hsa012122.69880650
10Tryptophan metabolism_Homo sapiens_hsa003802.63033056
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.62623664
12Nitrogen metabolism_Homo sapiens_hsa009102.56517436
13Butanoate metabolism_Homo sapiens_hsa006502.49911911
14Arginine biosynthesis_Homo sapiens_hsa002202.47703717
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47468110
16PPAR signaling pathway_Homo sapiens_hsa033202.23556959
17Peroxisome_Homo sapiens_hsa041462.12542612
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.97385696
19Complement and coagulation cascades_Homo sapiens_hsa046101.95590691
20beta-Alanine metabolism_Homo sapiens_hsa004101.95230141
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93345052
22Pyruvate metabolism_Homo sapiens_hsa006201.92608251
23Fatty acid elongation_Homo sapiens_hsa000621.87508181
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.87401253
25Carbon metabolism_Homo sapiens_hsa012001.84451311
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67175918
27Histidine metabolism_Homo sapiens_hsa003401.45873607
28Phenylalanine metabolism_Homo sapiens_hsa003601.45259932
29Chemical carcinogenesis_Homo sapiens_hsa052041.44964535
30Starch and sucrose metabolism_Homo sapiens_hsa005001.44100833
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43548591
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43159131
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38598949
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.38007980
35Caffeine metabolism_Homo sapiens_hsa002321.35743569
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32011147
37Retinol metabolism_Homo sapiens_hsa008301.31668578
38Tyrosine metabolism_Homo sapiens_hsa003501.25201372
39Sulfur metabolism_Homo sapiens_hsa009201.23575460
40Biosynthesis of amino acids_Homo sapiens_hsa012301.23288620
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.21040916
42Bile secretion_Homo sapiens_hsa049761.21027010
43Selenocompound metabolism_Homo sapiens_hsa004501.17141808
44Staphylococcus aureus infection_Homo sapiens_hsa051501.15767636
45Fat digestion and absorption_Homo sapiens_hsa049751.11619680
46Lysine degradation_Homo sapiens_hsa003101.07723899
47ABC transporters_Homo sapiens_hsa020101.06872586
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.03258107
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97622705
50Circadian rhythm_Homo sapiens_hsa047100.96042303
51Fatty acid biosynthesis_Homo sapiens_hsa000610.95563393
52Arginine and proline metabolism_Homo sapiens_hsa003300.94605086
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94401802
54Insulin secretion_Homo sapiens_hsa049110.92957692
55Folate biosynthesis_Homo sapiens_hsa007900.86314999
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82357541
57Protein export_Homo sapiens_hsa030600.81735651
58Mineral absorption_Homo sapiens_hsa049780.80628951
59Glycerolipid metabolism_Homo sapiens_hsa005610.78375135
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76333374
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74317759
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71703500
63Vitamin digestion and absorption_Homo sapiens_hsa049770.71417518
64Renin secretion_Homo sapiens_hsa049240.70353210
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63585427
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63225375
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.62527613
68Steroid biosynthesis_Homo sapiens_hsa001000.60097067
69Vitamin B6 metabolism_Homo sapiens_hsa007500.57860928
70Sulfur relay system_Homo sapiens_hsa041220.57840772
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.56960425
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.56770037
73Insulin resistance_Homo sapiens_hsa049310.56489427
74Glutathione metabolism_Homo sapiens_hsa004800.55392844
75Metabolic pathways_Homo sapiens_hsa011000.51736007
76Oxidative phosphorylation_Homo sapiens_hsa001900.51296385
77Parkinsons disease_Homo sapiens_hsa050120.50814029
78Pentose phosphate pathway_Homo sapiens_hsa000300.49280216
79Cardiac muscle contraction_Homo sapiens_hsa042600.46655911
80Ether lipid metabolism_Homo sapiens_hsa005650.46345680
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.44471249
82Glucagon signaling pathway_Homo sapiens_hsa049220.41261509
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40061144
84Galactose metabolism_Homo sapiens_hsa000520.39817223
85Calcium signaling pathway_Homo sapiens_hsa040200.39193451
86Fructose and mannose metabolism_Homo sapiens_hsa000510.38365891
87Serotonergic synapse_Homo sapiens_hsa047260.36880425
88Phototransduction_Homo sapiens_hsa047440.36549461
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36164659
90Collecting duct acid secretion_Homo sapiens_hsa049660.34898405
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34292867
92AMPK signaling pathway_Homo sapiens_hsa041520.33492339
93Dilated cardiomyopathy_Homo sapiens_hsa054140.32924445
94Purine metabolism_Homo sapiens_hsa002300.32670019
95Alzheimers disease_Homo sapiens_hsa050100.31051480
96Sphingolipid metabolism_Homo sapiens_hsa006000.29740100
97Pancreatic secretion_Homo sapiens_hsa049720.28330230
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27584222
99One carbon pool by folate_Homo sapiens_hsa006700.26706677
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26192108
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23575698
102Insulin signaling pathway_Homo sapiens_hsa049100.18151880
103Huntingtons disease_Homo sapiens_hsa050160.13900202
104Linoleic acid metabolism_Homo sapiens_hsa005910.11740921
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11438332
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.11286135
107Ovarian steroidogenesis_Homo sapiens_hsa049130.02472713
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.02137950
109Prion diseases_Homo sapiens_hsa050200.00450319
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1505781
111Protein digestion and absorption_Homo sapiens_hsa04974-0.1465536
112Type II diabetes mellitus_Homo sapiens_hsa04930-0.1357593
113Regulation of autophagy_Homo sapiens_hsa04140-0.1208162
114Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1003620
115Viral myocarditis_Homo sapiens_hsa05416-0.0742578
116Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0665289
117Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0654882
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0469737
119Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0139368

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