ETHE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the metallo beta-lactamase family of iron-containing proteins involved in the mitochondrial sulfide oxidation pathway. The encoded protein catalyzes the oxidation of a persulfide substrate to sulfite. Certain mutations in this gene cause ethylmalonic encephalopathy, an infantile metabolic disorder affecting the brain, gastrointestinal tract and peripheral vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.31676951
2L-phenylalanine catabolic process (GO:0006559)5.31676951
3L-phenylalanine metabolic process (GO:0006558)5.30909567
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.30909567
5glyoxylate metabolic process (GO:0046487)5.17600840
6aromatic amino acid family catabolic process (GO:0009074)5.08203947
7* sulfur amino acid catabolic process (GO:0000098)5.02173642
8indole-containing compound catabolic process (GO:0042436)4.89799248
9indolalkylamine catabolic process (GO:0046218)4.89799248
10tryptophan catabolic process (GO:0006569)4.89799248
11cysteine metabolic process (GO:0006534)4.78079501
12cellular ketone body metabolic process (GO:0046950)4.65585575
13regulation of vitamin metabolic process (GO:0030656)4.59791699
14tryptophan metabolic process (GO:0006568)4.54331229
15kynurenine metabolic process (GO:0070189)4.52900919
16bile acid and bile salt transport (GO:0015721)4.38821772
17flavonoid metabolic process (GO:0009812)4.38661006
18bile acid biosynthetic process (GO:0006699)4.22050013
19serine family amino acid catabolic process (GO:0009071)4.20754814
20lysine metabolic process (GO:0006553)4.19708101
21lysine catabolic process (GO:0006554)4.19708101
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.15455073
23homocysteine metabolic process (GO:0050667)4.15395202
24cellular glucuronidation (GO:0052695)4.14701291
25drug transmembrane transport (GO:0006855)4.09225524
26amino-acid betaine metabolic process (GO:0006577)4.09066300
27ketone body metabolic process (GO:1902224)4.00486937
28serine family amino acid biosynthetic process (GO:0009070)3.96119627
29urate metabolic process (GO:0046415)3.87409090
30serine family amino acid metabolic process (GO:0009069)3.84741560
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.83126372
32regulation of vitamin D biosynthetic process (GO:0060556)3.81484426
33glycine metabolic process (GO:0006544)3.80053959
34bile acid metabolic process (GO:0008206)3.77342306
35aromatic amino acid family metabolic process (GO:0009072)3.75838541
36urea cycle (GO:0000050)3.75768628
37urea metabolic process (GO:0019627)3.75768628
38glucuronate metabolic process (GO:0019585)3.74719863
39uronic acid metabolic process (GO:0006063)3.74719863
40drug transport (GO:0015893)3.73749162
41positive regulation of triglyceride lipase activity (GO:0061365)3.67784681
42positive regulation of lipoprotein lipase activity (GO:0051006)3.67784681
43killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.61937694
44disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.61937694
45GDP-mannose metabolic process (GO:0019673)3.60355708
46alpha-amino acid catabolic process (GO:1901606)3.55337096
47negative regulation of cholesterol transport (GO:0032375)3.54473506
48negative regulation of sterol transport (GO:0032372)3.54473506
49drug catabolic process (GO:0042737)3.54155321
50negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.52003904
51nitrogen cycle metabolic process (GO:0071941)3.52002784
52short-chain fatty acid metabolic process (GO:0046459)3.51797288
53valine metabolic process (GO:0006573)3.49339007
54ethanol oxidation (GO:0006069)3.45994943
55alpha-linolenic acid metabolic process (GO:0036109)3.45830692
56aldehyde catabolic process (GO:0046185)3.44396720
57* cellular amino acid catabolic process (GO:0009063)3.40917921
58glycosphingolipid catabolic process (GO:0046479)3.40179948
59benzene-containing compound metabolic process (GO:0042537)3.38736215
60adhesion of symbiont to host cell (GO:0044650)3.38079808
61virion attachment to host cell (GO:0019062)3.38079808
62complement activation, alternative pathway (GO:0006957)3.37510218
63negative regulation of fibrinolysis (GO:0051918)3.37204516
64fatty acid beta-oxidation (GO:0006635)3.36238642
65exogenous drug catabolic process (GO:0042738)3.34864097
66fatty acid oxidation (GO:0019395)3.34845735
67cellular biogenic amine catabolic process (GO:0042402)3.34152443
68amine catabolic process (GO:0009310)3.34152443
69indolalkylamine metabolic process (GO:0006586)3.32606956
70protein carboxylation (GO:0018214)3.32172444
71peptidyl-glutamic acid carboxylation (GO:0017187)3.32172444
72regulation of triglyceride catabolic process (GO:0010896)3.31939674
73NAD biosynthetic process (GO:0009435)3.30851489
74regulation of protein activation cascade (GO:2000257)3.30781670
75carnitine metabolic process (GO:0009437)3.30231703
76lipid oxidation (GO:0034440)3.28494876
77nicotinamide nucleotide biosynthetic process (GO:0019359)3.27203870
78pyridine nucleotide biosynthetic process (GO:0019363)3.27203870
79high-density lipoprotein particle remodeling (GO:0034375)3.25086157
80regulation of cytokine secretion involved in immune response (GO:0002739)3.23132861
81angiotensin maturation (GO:0002003)3.21086680
82* carboxylic acid catabolic process (GO:0046395)3.17181122
83* organic acid catabolic process (GO:0016054)3.17181122
84cellular modified amino acid catabolic process (GO:0042219)3.16606709
852-oxoglutarate metabolic process (GO:0006103)3.16580427
86glycolipid catabolic process (GO:0019377)3.13844811
87regulation of fibrinolysis (GO:0051917)3.12749914
88imidazole-containing compound metabolic process (GO:0052803)3.11547113
89regulation of complement activation (GO:0030449)3.10994708
90negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.10380267
91low-density lipoprotein particle remodeling (GO:0034374)3.08606041
92fatty acid catabolic process (GO:0009062)3.08516644
93protein-lipid complex remodeling (GO:0034368)3.08062803
94macromolecular complex remodeling (GO:0034367)3.08062803
95plasma lipoprotein particle remodeling (GO:0034369)3.08062803
96branched-chain amino acid metabolic process (GO:0009081)3.05251059
97monocarboxylic acid catabolic process (GO:0072329)3.04351890
98killing of cells of other organism (GO:0031640)3.04054990
99disruption of cells of other organism (GO:0044364)3.04054990
100branched-chain amino acid catabolic process (GO:0009083)3.03799108
101NIK/NF-kappaB signaling (GO:0038061)3.02916630
102fat-soluble vitamin biosynthetic process (GO:0042362)3.02590234
103tyrosine metabolic process (GO:0006570)3.01917866
104heme transport (GO:0015886)3.01202844
105drug metabolic process (GO:0017144)3.00968440
106intestinal absorption (GO:0050892)2.99640461
107regulation of cholesterol esterification (GO:0010872)2.98006302
108fructose metabolic process (GO:0006000)2.97998236
109immunoglobulin mediated immune response (GO:0016064)2.97232577
110* sulfur amino acid metabolic process (GO:0000096)2.95941954
111regulation of cholesterol metabolic process (GO:0090181)2.95780654
112phospholipid efflux (GO:0033700)2.95308833
113pinocytosis (GO:0006907)2.94953296
114eosinophil chemotaxis (GO:0048245)2.94762609
115adhesion of symbiont to host (GO:0044406)2.94092812
116coenzyme catabolic process (GO:0009109)2.93212557
117pyrimidine nucleoside catabolic process (GO:0046135)2.92755387
118NAD metabolic process (GO:0019674)2.91869779
119positive regulation of pseudopodium assembly (GO:0031274)2.90915974
120response to nitrosative stress (GO:0051409)2.89772190
121L-serine metabolic process (GO:0006563)2.89724457
122barbed-end actin filament capping (GO:0051016)2.89466888
123regulation of respiratory burst (GO:0060263)2.86933524
124negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.86249441
125cellular response to zinc ion (GO:0071294)2.77239030
126regulation of metalloenzyme activity (GO:0048552)2.77065097
127neutrophil activation involved in immune response (GO:0002283)2.76658577
128antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73821599
129mature B cell differentiation involved in immune response (GO:0002313)2.73104368
130regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.71543152
131regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.71463345
132ceramide catabolic process (GO:0046514)2.68502877
133desmosome organization (GO:0002934)2.68036438
134antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.67617970
135antigen processing and presentation of endogenous antigen (GO:0019883)2.65569503
136sphingolipid catabolic process (GO:0030149)2.64108365
137regulation of mononuclear cell migration (GO:0071675)2.63395130
138eosinophil migration (GO:0072677)2.62620072
139response to peptidoglycan (GO:0032494)2.60830074
140positive regulation of respiratory burst (GO:0060267)2.59366787
141oligosaccharide catabolic process (GO:0009313)2.59268951
142regulation of cellular extravasation (GO:0002691)2.57266646
143negative regulation of nitric oxide biosynthetic process (GO:0045019)2.56763406
144regulation of podosome assembly (GO:0071801)2.54778340
145NADH metabolic process (GO:0006734)2.54357575
146membrane lipid catabolic process (GO:0046466)2.53156101
147cyclooxygenase pathway (GO:0019371)2.51706750
148regulation of pseudopodium assembly (GO:0031272)2.51395478
149negative regulation of protein tyrosine kinase activity (GO:0061099)2.48793168
150oligosaccharide biosynthetic process (GO:0009312)2.44118716
151regulation of monocyte chemotaxis (GO:0090025)2.42077439
152renal system process involved in regulation of blood volume (GO:0001977)2.41621854
153regulation of chemokine biosynthetic process (GO:0045073)2.40943877
154positive regulation of chemokine biosynthetic process (GO:0045080)2.38165320
155transcytosis (GO:0045056)2.35752722
156antimicrobial humoral response (GO:0019730)2.34877685
157purine nucleotide salvage (GO:0032261)2.34791809
158regulation of antigen processing and presentation (GO:0002577)2.32839491
159positive regulation of Cdc42 GTPase activity (GO:0043089)2.32442403
160regulation of dendritic cell antigen processing and presentation (GO:0002604)2.32325847
161regulation of superoxide anion generation (GO:0032928)2.31217405
162negative regulation of receptor activity (GO:2000272)2.29303894
163B cell mediated immunity (GO:0019724)2.26798306
164positive regulation of antigen processing and presentation (GO:0002579)2.23824533
165cellular response to pH (GO:0071467)2.23211365
166type I interferon signaling pathway (GO:0060337)2.22962715
167cellular response to type I interferon (GO:0071357)2.22962715
168positive regulation of monocyte chemotaxis (GO:0090026)2.22878591
169antibacterial humoral response (GO:0019731)2.21979370
170hyaluronan catabolic process (GO:0030214)2.20438454
171nucleotide-sugar biosynthetic process (GO:0009226)2.19681865
172interferon-gamma-mediated signaling pathway (GO:0060333)2.19584281
173response to type I interferon (GO:0034340)2.18292901
174regulation of intracellular pH (GO:0051453)2.18022178
175Arp2/3 complex-mediated actin nucleation (GO:0034314)2.18008440
176sulfate transmembrane transport (GO:1902358)2.17894303
177regulation of RIG-I signaling pathway (GO:0039535)2.16888174
178regulation of guanylate cyclase activity (GO:0031282)2.16066856
179glycoside metabolic process (GO:0016137)2.13912249
180regulation of inflammatory response to antigenic stimulus (GO:0002861)2.13503725
181nucleotide salvage (GO:0043173)2.13166932
182decidualization (GO:0046697)2.13098997
183epoxygenase P450 pathway (GO:0019373)2.11958040
184regulation of plasminogen activation (GO:0010755)2.11948556
185lipopolysaccharide-mediated signaling pathway (GO:0031663)2.11533871
186regulation of T-helper 1 cell differentiation (GO:0045625)2.11257769
187deoxyribonucleotide catabolic process (GO:0009264)2.09244886
188arginine catabolic process (GO:0006527)2.09229250
189regulation of apoptotic process involved in morphogenesis (GO:1902337)2.08779789
190response to interferon-beta (GO:0035456)2.07650378
191positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.07287481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.42723328
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.08988897
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.75815285
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.48517742
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.48487335
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.61490202
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.49219357
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.97241884
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.77075093
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.74803200
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73673972
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.54310166
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.48862653
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.14926936
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00057126
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78318319
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77384186
18STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71705268
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71560752
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70400543
21* ELK3_25401928_ChIP-Seq_HUVEC_Human1.68832228
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67274419
23IRF8_27001747_Chip-Seq_BMDM_Mouse1.59891086
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58611669
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58121219
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57911834
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57643525
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.55981784
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55912589
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54036417
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53849708
32SOX2_20726797_ChIP-Seq_SW620_Human1.53450910
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52826235
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52512920
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52357200
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49151122
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46624696
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46408917
39RACK7_27058665_Chip-Seq_MCF-7_Human1.43382541
40P63_26484246_Chip-Seq_KERATINOCYTES_Human1.38339904
41* BCOR_27268052_Chip-Seq_Bcells_Human1.35074280
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.34563897
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33792590
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.30531409
45PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28678607
46VDR_21846776_ChIP-Seq_THP-1_Human1.28261161
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26232172
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.25316717
49* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24822771
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24292460
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23753137
52SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23630383
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23592905
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.23241145
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22845020
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22329770
57CDX2_20551321_ChIP-Seq_CACO-2_Human1.21286009
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21086140
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20793897
60GATA1_22025678_ChIP-Seq_K562_Human1.19684120
61ATF3_27146783_Chip-Seq_COLON_Human1.17839512
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.17735500
63TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.16897047
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16248664
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.15596828
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13512338
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12934209
68ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12296068
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12049122
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11960973
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11948490
72STAT1_20625510_ChIP-Seq_HELA_Human1.11725249
73AR_21909140_ChIP-Seq_LNCAP_Human1.11412978
74EST1_17652178_ChIP-ChIP_JURKAT_Human1.11372977
75E2F7_22180533_ChIP-Seq_HELA_Human1.10645474
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10213470
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.10098824
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08855686
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08324452
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08323714
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08164467
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.07374108
83GATA4_25053715_ChIP-Seq_YYC3_Human1.06899334
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06853195
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.06609948
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05862136
87BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02954437
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02772116
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02449954
90RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02134700
91E2F1_20622854_ChIP-Seq_HELA_Human1.02122496
92CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01607022
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01352086
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.00765756
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99686966
96* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99350561
97SPI1_23547873_ChIP-Seq_NB4_Human0.99279468
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98799705
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98522489
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98500212
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98500212
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98066362
103* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97997580
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97058252
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96975916
106GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96642235
107ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96508032
108SA1_27219007_Chip-Seq_Bcells_Human0.96036025
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95970459
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94658547
111ZNF263_19887448_ChIP-Seq_K562_Human0.94199241
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93364122
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93238964
114SCL_19346495_ChIP-Seq_HPC-7_Human0.92391811
115KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89937833
116MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89653701
117* BCL6_27268052_Chip-Seq_Bcells_Human0.89599586
118VDR_24763502_ChIP-Seq_THP-1_Human0.89134430
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89045114
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88119576
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86647221
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.85514308
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85009749
124XRN2_22483619_ChIP-Seq_HELA_Human0.84855793
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84246242
126* HNF4A_19822575_ChIP-Seq_HepG2_Human0.84236592
127CTCF_26484167_Chip-Seq_Bcells_Mouse0.84127412
128* GATA6_25053715_ChIP-Seq_YYC3_Human0.83830249
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83408000
130LXR_22292898_ChIP-Seq_THP-1_Human0.83072220
131CTCF_18555785_ChIP-Seq_MESCs_Mouse0.82980429
132CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82588628
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82485068
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82041520
135KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81869447
136VDR_23849224_ChIP-Seq_CD4+_Human0.81850694
137SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81619407
138PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81276664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.00761806
2MP0005360_urolithiasis5.96023550
3MP0005085_abnormal_gallbladder_physiolo4.87475392
4MP0005365_abnormal_bile_salt4.86841768
5MP0008875_abnormal_xenobiotic_pharmacok4.16469586
6MP0003806_abnormal_nucleotide_metabolis4.04003131
7MP0003252_abnormal_bile_duct2.66973381
8MP0001666_abnormal_nutrient_absorption2.62993328
9MP0005332_abnormal_amino_acid2.59985679
10MP0009840_abnormal_foam_cell2.49677069
11MP0010329_abnormal_lipoprotein_level2.35042755
12MP0006082_CNS_inflammation2.31385536
13MP0004019_abnormal_vitamin_homeostasis2.21710030
14MP0003303_peritoneal_inflammation2.16695211
15MP0003186_abnormal_redox_activity2.13463769
16MP0003191_abnormal_cellular_cholesterol2.13387223
17MP0005083_abnormal_biliary_tract2.03033826
18MP0002138_abnormal_hepatobiliary_system1.98085253
19* MP0009643_abnormal_urine_homeostasis1.86171954
20MP0005319_abnormal_enzyme/_coenzyme1.80156918
21MP0003195_calcinosis1.77044558
22MP0000609_abnormal_liver_physiology1.71036822
23MP0001764_abnormal_homeostasis1.70911875
24MP0003183_abnormal_peptide_metabolism1.68759209
25MP0006054_spinal_hemorrhage1.67708517
26MP0005451_abnormal_body_composition1.65002555
27MP0005387_immune_system_phenotype1.61790778
28MP0001790_abnormal_immune_system1.61790778
29MP0010155_abnormal_intestine_physiology1.59993050
30MP0009785_altered_susceptibility_to1.59192976
31* MP0005636_abnormal_mineral_homeostasis1.57269480
32MP0001533_abnormal_skeleton_physiology1.56911786
33MP0003868_abnormal_feces_composition1.52065664
34MP0002118_abnormal_lipid_homeostasis1.49966975
35* MP0005584_abnormal_enzyme/coenzyme_acti1.47440217
36MP0006036_abnormal_mitochondrial_physio1.44915851
37MP0008438_abnormal_cutaneous_collagen1.44443193
38MP0003866_abnormal_defecation1.38399518
39MP0003172_abnormal_lysosome_physiology1.37849640
40MP0005058_abnormal_lysosome_morphology1.37105289
41MP0003300_gastrointestinal_ulcer1.36568675
42MP0001873_stomach_inflammation1.32721592
43MP0009764_decreased_sensitivity_to1.32485966
44MP0003436_decreased_susceptibility_to1.32219660
45MP0005023_abnormal_wound_healing1.31771653
46MP0000858_altered_metastatic_potential1.31301142
47MP0008469_abnormal_protein_level1.30580179
48MP0003724_increased_susceptibility_to1.30346491
49MP0001663_abnormal_digestive_system1.28822799
50MP0005084_abnormal_gallbladder_morpholo1.28441584
51MP0004264_abnormal_extraembryonic_tissu1.27311484
52MP0003656_abnormal_erythrocyte_physiolo1.27298762
53MP0001853_heart_inflammation1.26036119
54MP0010352_gastrointestinal_tract_polyps1.24585623
55MP0001542_abnormal_bone_strength1.23517429
56MP0000343_altered_response_to1.23208927
57MP0005165_increased_susceptibility_to1.20406788
58MP0001756_abnormal_urination1.16469380
59MP0005025_abnormal_response_to1.16426655
60MP0004510_myositis1.14801671
61MP0000490_abnormal_crypts_of1.14473243
62MP0001835_abnormal_antigen_presentation1.12940286
63MP0000598_abnormal_liver_morphology1.12613650
64MP0002796_impaired_skin_barrier1.11161965
65MP0005670_abnormal_white_adipose1.09075641
66MP0001845_abnormal_inflammatory_respons1.08503125
67MP0001765_abnormal_ion_homeostasis1.06760820
68MP0003448_altered_tumor_morphology1.06646009
69MP0005257_abnormal_intraocular_pressure1.06594117
70MP0002136_abnormal_kidney_physiology1.03590321
71MP0005464_abnormal_platelet_physiology1.02956083
72MP0000604_amyloidosis1.02317462
73MP0005381_digestive/alimentary_phenotyp1.01922636
74MP0010234_abnormal_vibrissa_follicle1.00133449
75MP0008004_abnormal_stomach_pH0.99163061
76MP0004147_increased_porphyrin_level0.98081000
77MP0003878_abnormal_ear_physiology0.97108807
78MP0005377_hearing/vestibular/ear_phenot0.97108807
79MP0008260_abnormal_autophagy0.96902455
80MP0002060_abnormal_skin_morphology0.96292277
81MP0002419_abnormal_innate_immunity0.95391091
82MP0003453_abnormal_keratinocyte_physiol0.94231736
83MP0003693_abnormal_embryo_hatching0.92755527
84MP0001849_ear_inflammation0.92556083
85MP0000477_abnormal_intestine_morphology0.92289385
86MP0001216_abnormal_epidermal_layer0.91141166
87MP0006035_abnormal_mitochondrial_morpho0.90356763
88MP0003950_abnormal_plasma_membrane0.90019362
89MP0009379_abnormal_foot_pigmentation0.89402691
90MP0004043_abnormal_pH_regulation0.89145747
91MP0003279_aneurysm0.88861859
92MP0002822_catalepsy0.88211355
93MP0002998_abnormal_bone_remodeling0.88025976
94* MP0009642_abnormal_blood_homeostasis0.88012847
95MP0009763_increased_sensitivity_to0.87764011
96MP0000678_abnormal_parathyroid_gland0.87157974
97MP0002148_abnormal_hypersensitivity_rea0.86592352
98MP0002396_abnormal_hematopoietic_system0.86522233
99MP0001664_abnormal_digestion0.85658532
100MP0005390_skeleton_phenotype0.84275984
101MP0000685_abnormal_immune_system0.83126052
102MP0005164_abnormal_response_to0.82816889
103MP0005310_abnormal_salivary_gland0.82437313
104MP0005167_abnormal_blood-brain_barrier0.81899485
105MP0002876_abnormal_thyroid_physiology0.79730375
106MP0005501_abnormal_skin_physiology0.79631921
107MP0005166_decreased_susceptibility_to0.79470522
108MP0008873_increased_physiological_sensi0.78639029
109MP0002254_reproductive_system_inflammat0.78365375
110MP0001800_abnormal_humoral_immune0.76155613
111* MP0005376_homeostasis/metabolism_phenot0.75038374
112MP0003705_abnormal_hypodermis_morpholog0.73702792
113MP0002132_abnormal_respiratory_system0.72935977
114MP0004947_skin_inflammation0.72886399
115MP0000465_gastrointestinal_hemorrhage0.72619079
116MP0002166_altered_tumor_susceptibility0.68530095
117MP0002452_abnormal_antigen_presenting0.67850247
118MP0009333_abnormal_splenocyte_physiolog0.67723235
119MP0005397_hematopoietic_system_phenotyp0.67643409
120MP0001545_abnormal_hematopoietic_system0.67643409
121MP0002723_abnormal_immune_serum0.67562725
122MP0003646_muscle_fatigue0.65920273
123MP0005408_hypopigmentation0.65326251
124MP0009765_abnormal_xenobiotic_induced0.64395669
125MP0005671_abnormal_response_to0.64307669
126MP0003638_abnormal_response/metabolism_0.62541692
127* MP0005266_abnormal_metabolism0.62332610
128MP0009697_abnormal_copulation0.62235268
129MP0003718_maternal_effect0.62015086
130MP0001819_abnormal_immune_cell0.61379822
131MP0005000_abnormal_immune_tolerance0.61051950
132MP0000689_abnormal_spleen_morphology0.60873303
133MP0002420_abnormal_adaptive_immunity0.60129952
134MP0004782_abnormal_surfactant_physiolog0.58524829
135MP0003075_altered_response_to0.58483320
136MP0003011_delayed_dark_adaptation0.58195893
137MP0005647_abnormal_sex_gland0.57004063

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.05443658
2Intrahepatic cholestasis (HP:0001406)4.85741152
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.74591427
4Xanthomatosis (HP:0000991)4.06669744
5Hyperammonemia (HP:0001987)3.92561685
6Abnormality of glycolipid metabolism (HP:0010969)3.88395102
7Abnormality of liposaccharide metabolism (HP:0010968)3.88395102
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.88395102
9Deep venous thrombosis (HP:0002625)3.84782462
10Prolonged partial thromboplastin time (HP:0003645)3.83734850
11Abnormality of fatty-acid metabolism (HP:0004359)3.77952748
12Hypobetalipoproteinemia (HP:0003563)3.77325819
13Hyperglycinuria (HP:0003108)3.77233338
14Abnormality of glutamine family amino acid metabolism (HP:0010902)3.56346543
15Hyperglycinemia (HP:0002154)3.54928112
16Hypoglycemic coma (HP:0001325)3.51843380
17Generalized aminoaciduria (HP:0002909)3.49959115
18Abnormality of serine family amino acid metabolism (HP:0010894)3.41312838
19Abnormality of glycine metabolism (HP:0010895)3.41312838
20* Abnormality of dicarboxylic acid metabolism (HP:0010995)3.34761485
21* Dicarboxylic aciduria (HP:0003215)3.34761485
22Hyperlipoproteinemia (HP:0010980)3.33383943
23Dysostosis multiplex (HP:0000943)3.23458295
24Ketosis (HP:0001946)3.22902685
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.15630673
26Abnormality of pyrimidine metabolism (HP:0004353)3.12860783
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.07253935
28Fat malabsorption (HP:0002630)3.05289902
29Proximal tubulopathy (HP:0000114)3.04882612
30Gout (HP:0001997)3.02872028
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.02867776
32Joint hemorrhage (HP:0005261)3.02737522
33Hepatic necrosis (HP:0002605)3.00558656
34Lethargy (HP:0001254)2.89487708
35Complement deficiency (HP:0004431)2.86825042
36Elevated erythrocyte sedimentation rate (HP:0003565)2.84319540
37Abnormality of nucleobase metabolism (HP:0010932)2.83036146
38Hyperbilirubinemia (HP:0002904)2.80524318
39Abnormality of polysaccharide metabolism (HP:0011012)2.77974501
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.77974501
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.77974501
42Abnormality of methionine metabolism (HP:0010901)2.77791599
43Hypolipoproteinemia (HP:0010981)2.77407469
44Abnormality of macrophages (HP:0004311)2.73471463
45Mucopolysacchariduria (HP:0008155)2.72057460
46Urinary glycosaminoglycan excretion (HP:0003541)2.72057460
47Glycosuria (HP:0003076)2.72042341
48Abnormality of urine glucose concentration (HP:0011016)2.72042341
49Alkalosis (HP:0001948)2.70991863
50Cerebral edema (HP:0002181)2.68680027
51Abnormality of purine metabolism (HP:0004352)2.68123828
52Delayed CNS myelination (HP:0002188)2.63022975
53Metabolic acidosis (HP:0001942)2.60469188
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.60335751
55Abnormality of the common coagulation pathway (HP:0010990)2.59262796
56Increased muscle lipid content (HP:0009058)2.56623761
57Vertebral compression fractures (HP:0002953)2.56545745
58Malnutrition (HP:0004395)2.54518955
59Conjugated hyperbilirubinemia (HP:0002908)2.54254410
60Nausea (HP:0002018)2.51826056
61Ketoacidosis (HP:0001993)2.51562967
62Abnormality of serum amino acid levels (HP:0003112)2.50317020
63Abnormal tarsal ossification (HP:0008369)2.48060705
64Vacuolated lymphocytes (HP:0001922)2.47234282
65Hepatocellular necrosis (HP:0001404)2.41021137
66Steatorrhea (HP:0002570)2.40539814
67Abnormality of proline metabolism (HP:0010907)2.40079875
68Hydroxyprolinuria (HP:0003080)2.40079875
69Loss of speech (HP:0002371)2.38725257
70Abnormal cartilage morphology (HP:0002763)2.37036362
71Increased intramyocellular lipid droplets (HP:0012240)2.36369978
72Acute encephalopathy (HP:0006846)2.35240472
73Vomiting (HP:0002013)2.33958563
74Reduced antithrombin III activity (HP:0001976)2.33059230
75Decreased circulating renin level (HP:0003351)2.33028887
76Abnormality of the intrinsic pathway (HP:0010989)2.32272758
77Hyperactive renin-angiotensin system (HP:0000841)2.31866960
78Hypoalphalipoproteinemia (HP:0003233)2.31424717
79Eczematoid dermatitis (HP:0000976)2.29200499
80Recurrent abscess formation (HP:0002722)2.28954477
81Pustule (HP:0200039)2.28286296
82Metabolic alkalosis (HP:0200114)2.28259990
83Spontaneous abortion (HP:0005268)2.27692480
84Ileus (HP:0002595)2.27068904
85Congenital sensorineural hearing impairment (HP:0008527)2.25431176
86Prolonged neonatal jaundice (HP:0006579)2.25417915
87Abnormality of complement system (HP:0005339)2.24022795
88Metaphyseal irregularity (HP:0003025)2.23730397
89Late onset (HP:0003584)2.22866623
90Amyloidosis (HP:0011034)2.21997748
91Recurrent bacterial skin infections (HP:0005406)2.21657999
92Hyperuricemia (HP:0002149)2.21611043
93Increased purine levels (HP:0004368)2.21611043
94Thin bony cortex (HP:0002753)2.20182265
95Lipid accumulation in hepatocytes (HP:0006561)2.19256317
96Pancreatitis (HP:0001733)2.19161428
97Hemorrhage of the eye (HP:0011885)2.18258660
98Recurrent gram-negative bacterial infections (HP:0005420)2.17793757
99Epidermoid cyst (HP:0200040)2.17112679
100Axonal loss (HP:0003447)2.14268814
101Abnormality of renin-angiotensin system (HP:0000847)2.14176952
102Systemic lupus erythematosus (HP:0002725)2.10736159
103Hypercholesterolemia (HP:0003124)2.10554347
104Abnormality of the vasculature of the conjunctiva (HP:0008054)2.09301034
105Myositis (HP:0100614)2.08204389
106Increased cerebral lipofuscin (HP:0011813)2.06973934
107Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06935392
108Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06935392
109Thrombocytosis (HP:0001894)2.06860683
110Abdominal distention (HP:0003270)2.03496538
111Methylmalonic aciduria (HP:0012120)2.03186024
112Spontaneous hematomas (HP:0007420)2.03087261
113* Lactic acidosis (HP:0003128)2.00774671
114Hepatocellular carcinoma (HP:0001402)2.00031224
115Glomerulonephritis (HP:0000099)1.99817014
116Hyperphosphaturia (HP:0003109)1.99627652
117Mitochondrial inheritance (HP:0001427)1.99548343
118Vascular calcification (HP:0004934)1.99092293
119Increased CSF lactate (HP:0002490)1.96819186
120Abnormal trabecular bone morphology (HP:0100671)1.95036341
121Purpura (HP:0000979)1.94135664
122Myocardial infarction (HP:0001658)1.91145645
123Increased IgM level (HP:0003496)1.90894908
124Abnormality of iron homeostasis (HP:0011031)1.90893007
125Increased neuronal autofluorescent lipopigment (HP:0002074)1.90885372
126Symptomatic seizures (HP:0011145)1.90219551
127* Petechiae (HP:0000967)1.89160856
128Abnormality of the costochondral junction (HP:0000919)1.88638141
129Renal cortical cysts (HP:0000803)1.88544789
130Hepatosplenomegaly (HP:0001433)1.88146453
131Irritability (HP:0000737)1.88052235
132Neonatal onset (HP:0003623)1.87439506
133Progressive neurologic deterioration (HP:0002344)1.87244072
134Abnormality of transition element cation homeostasis (HP:0011030)1.86829509
135Increased serum ferritin (HP:0003281)1.82999941
136Fragile skin (HP:0001030)1.82655134
137Joint stiffness (HP:0001387)1.82644679
138Renal Fanconi syndrome (HP:0001994)1.82538601
139Conjunctival telangiectasia (HP:0000524)1.81789307
140Bone pain (HP:0002653)1.81225671
141Abnormal enzyme/coenzyme activity (HP:0012379)1.80893604
142Rough bone trabeculation (HP:0100670)1.80401360
143Abnormal mitochondria in muscle tissue (HP:0008316)1.79817438
144Pili torti (HP:0003777)1.79352872
145Nephritis (HP:0000123)1.78751405
146Flat acetabular roof (HP:0003180)1.78439971
147Elevated hepatic transaminases (HP:0002910)1.77870892
148Increased hepatocellular lipid droplets (HP:0006565)1.77834035
149Hyperparathyroidism (HP:0000843)1.77759900
150Abnormal hair laboratory examination (HP:0003328)1.77015839
151Increased serum lactate (HP:0002151)1.76741664
152Gingival bleeding (HP:0000225)1.75597274
153Gastrointestinal dysmotility (HP:0002579)1.75538165
154Alopecia of scalp (HP:0002293)1.74204459
155Urticaria (HP:0001025)1.72554226
156Hypergammaglobulinemia (HP:0010702)1.71847249
157Cervical subluxation (HP:0003308)1.70315529
158Right ventricular cardiomyopathy (HP:0011663)1.69992113
159Flattened epiphyses (HP:0003071)1.69301771
160Hypertensive crisis (HP:0100735)1.68648026
161Basal ganglia calcification (HP:0002135)1.67409248
162Premature rupture of membranes (HP:0001788)1.66373336
163Elevated alkaline phosphatase (HP:0003155)1.64334364
164Obstructive lung disease (HP:0006536)1.64049524
165Chronic obstructive pulmonary disease (HP:0006510)1.64049524
166Autoimmune thrombocytopenia (HP:0001973)1.62760021
167Vasculitis (HP:0002633)1.61918994
168Hemoptysis (HP:0002105)1.61429026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.53370257
2TAOK34.32021994
3MST1R3.89792751
4EPHA23.13088399
5ERN13.10432679
6NME22.81972533
7MYLK2.30149546
8PIM22.25912977
9PIK3CA2.15647908
10STK162.08156628
11KDR1.97922166
12FLT31.91345463
13TESK21.70943554
14EIF2AK31.70432429
15MAP2K31.66251530
16MAP2K21.66049840
17MAP4K11.62206394
18MAP3K121.61717264
19TYK21.54860122
20ABL21.50380921
21TBK11.49435735
22IRAK31.48912472
23MAP3K111.45595770
24TAOK21.45365704
25VRK21.38501228
26BTK1.36224125
27EIF2AK11.35044257
28BUB11.34177494
29GRK61.33629437
30FGFR41.33561487
31KIT1.33521119
32IRAK41.33006103
33DDR21.32725150
34MAPK111.31995078
35PDK21.31660732
36WEE11.30919197
37PIK3CG1.28065279
38TEC1.27348836
39ARAF1.25875634
40BLK1.24555631
41GRK71.23273647
42NEK11.23260516
43LIMK11.22598148
44STK241.21344101
45BMPR20.98319329
46IKBKE0.97095519
47CDK190.96683909
48TESK10.96581828
49MAPKAPK30.96495782
50PKN20.93115176
51NEK90.93046184
52ERBB40.92508999
53MAP3K80.91939304
54MAP3K70.91700594
55PRKG20.91665875
56ZAP700.89823347
57MAP2K60.88123114
58CSK0.85557734
59SMG10.83818035
60MAP3K140.83205821
61TXK0.82497724
62PIM10.81466834
63ZAK0.81231760
64PRPF4B0.80561745
65MAP3K30.80012108
66LRRK20.79814582
67MET0.79151283
68RPS6KB20.78607161
69EPHB10.76953764
70SCYL20.76890390
71NME10.76597569
72FRK0.74866499
73MAPK40.74455254
74PTK20.73576100
75RIPK40.72756116
76CAMKK20.72555804
77MATK0.71952499
78PAK40.71810549
79BRSK20.70504842
80CSF1R0.69373291
81MOS0.68537267
82BRAF0.66594014
83TAOK10.62170935
84PTK60.61471428
85SYK0.60298930
86JAK20.60232657
87EEF2K0.59136341
88PRKAA20.57936086
89SIK10.55805814
90LYN0.55508781
91PRKD20.54646045
92STK100.54154428
93AURKB0.53097672
94DAPK30.52095041
95EPHB20.51744379
96PBK0.51465968
97CDC42BPA0.51453611
98ILK0.50801012
99VRK10.50715277
100ACVR1B0.48364976
101INSRR0.48223475
102DAPK10.47906446
103RIPK10.46875424
104FGR0.46008934
105PDPK10.45341790
106TGFBR10.45221785
107RPS6KA40.45075558
108TLK10.43658696
109MAP3K10.43423864
110PLK40.42156602
111LMTK20.42037279
112IKBKB0.41842664
113NLK0.41707327
114PINK10.41512992
115ADRBK20.41170285
116RPS6KA60.40755594
117MAPKAPK20.40700249
118TGFBR20.40125033
119WNK40.39972127
120TIE10.39609119
121JAK30.39557173
122SIK30.39307590
123DYRK30.39110606
124LCK0.39011099
125MAP3K50.38848824
126TTK0.37766184
127HCK0.37671491
128MAP2K10.37641696
129PRKCD0.37007612
130PRKCI0.36606358
131BMX0.36510091
132TRPM70.36184826
133MST40.35875747
134MAP3K60.35665713
135PAK10.34945691
136MAP4K20.32198701
137ADRBK10.32119802
138GRK10.31130029

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.38273668
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.31235337
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73539135
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.61926835
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.53368460
6Asthma_Homo sapiens_hsa053102.40943264
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.35764619
8Tryptophan metabolism_Homo sapiens_hsa003802.28152123
9Fatty acid degradation_Homo sapiens_hsa000712.27407683
10Allograft rejection_Homo sapiens_hsa053302.20801293
11Butanoate metabolism_Homo sapiens_hsa006502.13841662
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.13315108
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06472805
14* Sulfur metabolism_Homo sapiens_hsa009202.01344001
15Peroxisome_Homo sapiens_hsa041462.00468354
16Arginine biosynthesis_Homo sapiens_hsa002201.95184925
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92796954
18Propanoate metabolism_Homo sapiens_hsa006401.91768702
19Autoimmune thyroid disease_Homo sapiens_hsa053201.90511505
20Graft-versus-host disease_Homo sapiens_hsa053321.90288523
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.89207329
22Histidine metabolism_Homo sapiens_hsa003401.82244906
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79705204
24Nitrogen metabolism_Homo sapiens_hsa009101.79536550
25Chemical carcinogenesis_Homo sapiens_hsa052041.78937595
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76954399
27Sulfur relay system_Homo sapiens_hsa041221.74318708
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.72958226
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.72587815
30Folate biosynthesis_Homo sapiens_hsa007901.72153297
31Complement and coagulation cascades_Homo sapiens_hsa046101.71099120
32Lysosome_Homo sapiens_hsa041421.62355790
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57689646
34Carbon metabolism_Homo sapiens_hsa012001.57611844
35beta-Alanine metabolism_Homo sapiens_hsa004101.53769387
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.51803523
37Rheumatoid arthritis_Homo sapiens_hsa053231.51760725
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49380255
39Selenocompound metabolism_Homo sapiens_hsa004501.47182432
40Type I diabetes mellitus_Homo sapiens_hsa049401.45953874
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41614500
42Pyruvate metabolism_Homo sapiens_hsa006201.41185593
43PPAR signaling pathway_Homo sapiens_hsa033201.40890134
44Caffeine metabolism_Homo sapiens_hsa002321.40571918
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39532217
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.38737028
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37733700
48Starch and sucrose metabolism_Homo sapiens_hsa005001.37277343
49Retinol metabolism_Homo sapiens_hsa008301.37190899
50Pentose phosphate pathway_Homo sapiens_hsa000301.36296529
51Pertussis_Homo sapiens_hsa051331.35184683
52Fatty acid metabolism_Homo sapiens_hsa012121.34706545
53Leishmaniasis_Homo sapiens_hsa051401.31157262
54Glutathione metabolism_Homo sapiens_hsa004801.29823341
55Biosynthesis of amino acids_Homo sapiens_hsa012301.25101154
56Bile secretion_Homo sapiens_hsa049761.24453373
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.23319841
58Phenylalanine metabolism_Homo sapiens_hsa003601.19631087
59Staphylococcus aureus infection_Homo sapiens_hsa051501.17177357
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12544840
61Ribosome_Homo sapiens_hsa030101.11767806
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09869194
63Antigen processing and presentation_Homo sapiens_hsa046121.06770390
64Oxidative phosphorylation_Homo sapiens_hsa001901.06744606
65Fat digestion and absorption_Homo sapiens_hsa049751.06198812
66Fructose and mannose metabolism_Homo sapiens_hsa000511.02154859
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99233901
68Viral myocarditis_Homo sapiens_hsa054160.99214307
69Tyrosine metabolism_Homo sapiens_hsa003500.95827064
70Fatty acid elongation_Homo sapiens_hsa000620.95769100
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94980370
72Shigellosis_Homo sapiens_hsa051310.94471768
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91958098
74Parkinsons disease_Homo sapiens_hsa050120.91723938
75Salmonella infection_Homo sapiens_hsa051320.91707978
76Galactose metabolism_Homo sapiens_hsa000520.91494629
77Hematopoietic cell lineage_Homo sapiens_hsa046400.91437477
78Arginine and proline metabolism_Homo sapiens_hsa003300.90694041
79One carbon pool by folate_Homo sapiens_hsa006700.90478590
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88762483
81Vitamin digestion and absorption_Homo sapiens_hsa049770.87839812
82Tuberculosis_Homo sapiens_hsa051520.87371015
83Vibrio cholerae infection_Homo sapiens_hsa051100.87085472
84Osteoclast differentiation_Homo sapiens_hsa043800.86305223
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82814016
86Phagosome_Homo sapiens_hsa041450.80605576
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.80054109
88Sphingolipid metabolism_Homo sapiens_hsa006000.79695382
89Proteasome_Homo sapiens_hsa030500.77879150
90ABC transporters_Homo sapiens_hsa020100.76576623
91Toxoplasmosis_Homo sapiens_hsa051450.76375801
92Vitamin B6 metabolism_Homo sapiens_hsa007500.75593430
93Metabolic pathways_Homo sapiens_hsa011000.75459944
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75171842
95Pyrimidine metabolism_Homo sapiens_hsa002400.73227887
96Influenza A_Homo sapiens_hsa051640.71872643
97Collecting duct acid secretion_Homo sapiens_hsa049660.71871731
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.70142190
99DNA replication_Homo sapiens_hsa030300.68437973
100TNF signaling pathway_Homo sapiens_hsa046680.67908938
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67466288
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62928113
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62241484
104African trypanosomiasis_Homo sapiens_hsa051430.61682566
105Steroid biosynthesis_Homo sapiens_hsa001000.60151123
106Malaria_Homo sapiens_hsa051440.57013808
107Other glycan degradation_Homo sapiens_hsa005110.56575756
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56506895
109Glycerolipid metabolism_Homo sapiens_hsa005610.56383579
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53554224
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53524110
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52925221
113Primary immunodeficiency_Homo sapiens_hsa053400.52201863
114Herpes simplex infection_Homo sapiens_hsa051680.50085920
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49997375
116Alzheimers disease_Homo sapiens_hsa050100.48813980
117Mineral absorption_Homo sapiens_hsa049780.47930062
118Hepatitis C_Homo sapiens_hsa051600.44285614
119Linoleic acid metabolism_Homo sapiens_hsa005910.44122643
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43416243
121Huntingtons disease_Homo sapiens_hsa050160.42795336
122Arachidonic acid metabolism_Homo sapiens_hsa005900.35684213
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32511481
124Base excision repair_Homo sapiens_hsa034100.27750195
125RNA polymerase_Homo sapiens_hsa030200.23483184
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.20691103
127Regulation of autophagy_Homo sapiens_hsa041400.18556911
128Lysine degradation_Homo sapiens_hsa003100.17969577
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.17024594
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16362594
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15860148
132Mismatch repair_Homo sapiens_hsa034300.15154809
133Renin-angiotensin system_Homo sapiens_hsa046140.14957777
134Legionellosis_Homo sapiens_hsa051340.12961201
135Protein export_Homo sapiens_hsa030600.12887709
136Systemic lupus erythematosus_Homo sapiens_hsa053220.11250760
137Purine metabolism_Homo sapiens_hsa002300.11156544
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.09620863

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