ETNK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of choline/ethanolamine kinase family which catalyzes the first step of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine diphosphate (CDP) ethanolamine pathway. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.75747054
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.75747054
3L-phenylalanine metabolic process (GO:0006558)7.40908430
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.40908430
5aromatic amino acid family catabolic process (GO:0009074)6.96533841
6exogenous drug catabolic process (GO:0042738)6.50001395
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.27229962
8tryptophan catabolic process (GO:0006569)6.25305230
9indole-containing compound catabolic process (GO:0042436)6.25305230
10indolalkylamine catabolic process (GO:0046218)6.25305230
11kynurenine metabolic process (GO:0070189)6.10410864
12epoxygenase P450 pathway (GO:0019373)6.07103063
13bile acid biosynthetic process (GO:0006699)6.02440519
14sperm motility (GO:0030317)5.97753181
15omega-hydroxylase P450 pathway (GO:0097267)5.93591654
16fusion of sperm to egg plasma membrane (GO:0007342)5.88781585
17urea cycle (GO:0000050)5.88748690
18urea metabolic process (GO:0019627)5.88748690
19tryptophan metabolic process (GO:0006568)5.88571469
20glyoxylate metabolic process (GO:0046487)5.77936187
21acrosome reaction (GO:0007340)5.75769040
22alpha-linolenic acid metabolic process (GO:0036109)5.59472120
23negative regulation of fibrinolysis (GO:0051918)5.58633652
24high-density lipoprotein particle remodeling (GO:0034375)5.55032545
25nitrogen cycle metabolic process (GO:0071941)5.41652381
26sulfur amino acid catabolic process (GO:0000098)5.40855795
27regulation of fibrinolysis (GO:0051917)5.38971962
28peptidyl-glutamic acid carboxylation (GO:0017187)5.38564571
29protein carboxylation (GO:0018214)5.38564571
30complement activation, alternative pathway (GO:0006957)5.38498413
31cysteine metabolic process (GO:0006534)5.37459505
32regulation of protein activation cascade (GO:2000257)5.33062366
33serine family amino acid catabolic process (GO:0009071)5.22012049
34bile acid metabolic process (GO:0008206)5.11662150
35aromatic amino acid family metabolic process (GO:0009072)5.06112260
36regulation of complement activation (GO:0030449)4.98535850
37homocysteine metabolic process (GO:0050667)4.95669054
38tyrosine metabolic process (GO:0006570)4.95666328
39reverse cholesterol transport (GO:0043691)4.87027628
40regulation of triglyceride catabolic process (GO:0010896)4.84780060
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.81865859
42regulation of cholesterol esterification (GO:0010872)4.79769383
43alpha-amino acid catabolic process (GO:1901606)4.73809639
44protein-lipid complex remodeling (GO:0034368)4.73312549
45macromolecular complex remodeling (GO:0034367)4.73312549
46plasma lipoprotein particle remodeling (GO:0034369)4.73312549
47lysine catabolic process (GO:0006554)4.67218453
48lysine metabolic process (GO:0006553)4.67218453
49amino-acid betaine metabolic process (GO:0006577)4.66045602
50drug metabolic process (GO:0017144)4.62528900
51triglyceride homeostasis (GO:0070328)4.61323641
52acylglycerol homeostasis (GO:0055090)4.61323641
53negative regulation of sterol transport (GO:0032372)4.57440833
54negative regulation of cholesterol transport (GO:0032375)4.57440833
55phospholipid efflux (GO:0033700)4.49789452
56coenzyme catabolic process (GO:0009109)4.48912967
57glycine metabolic process (GO:0006544)4.44355664
58indolalkylamine metabolic process (GO:0006586)4.42848809
59oxidative demethylation (GO:0070989)4.42645498
60cellular ketone body metabolic process (GO:0046950)4.40294673
61bile acid and bile salt transport (GO:0015721)4.38612582
62imidazole-containing compound metabolic process (GO:0052803)4.38411275
63plasma membrane fusion (GO:0045026)4.37295958
64cellular amino acid catabolic process (GO:0009063)4.34844887
65cellular biogenic amine catabolic process (GO:0042402)4.33275780
66amine catabolic process (GO:0009310)4.33275780
67plasma lipoprotein particle clearance (GO:0034381)4.31650857
68glutamate metabolic process (GO:0006536)4.29570899
69cellular glucuronidation (GO:0052695)4.26663616
70sperm capacitation (GO:0048240)4.25768584
71benzene-containing compound metabolic process (GO:0042537)4.22879686
72serine family amino acid metabolic process (GO:0009069)4.22582516
73intestinal cholesterol absorption (GO:0030299)4.21417097
74ethanol metabolic process (GO:0006067)4.19316533
75cholesterol efflux (GO:0033344)4.18556645
76arginine metabolic process (GO:0006525)4.14381349
77cellular modified amino acid catabolic process (GO:0042219)4.11446409
78regulation of plasminogen activation (GO:0010755)4.10817148
79ethanol oxidation (GO:0006069)4.09611550
80phenylpropanoid metabolic process (GO:0009698)4.08823389
81dicarboxylic acid biosynthetic process (GO:0043650)4.05860555
82serine family amino acid biosynthetic process (GO:0009070)4.02820189
83aldehyde catabolic process (GO:0046185)4.00363786
84fibrinolysis (GO:0042730)3.98616703
85drug catabolic process (GO:0042737)3.97618131
86chromosome condensation (GO:0030261)3.96653235
87spermatid development (GO:0007286)3.93900269
88plasma lipoprotein particle assembly (GO:0034377)3.92339184
89binding of sperm to zona pellucida (GO:0007339)3.91690497
90low-density lipoprotein particle remodeling (GO:0034374)3.89718649
91regulation of bile acid biosynthetic process (GO:0070857)3.83769545
92cofactor catabolic process (GO:0051187)3.81916553
93ketone body metabolic process (GO:1902224)3.80721725
94complement activation, classical pathway (GO:0006958)3.78964861
95uronic acid metabolic process (GO:0006063)3.78901057
96glucuronate metabolic process (GO:0019585)3.78901057
97blood coagulation, intrinsic pathway (GO:0007597)3.78333881
98organic acid catabolic process (GO:0016054)3.77210368
99carboxylic acid catabolic process (GO:0046395)3.77210368
100DNA packaging (GO:0006323)3.76549940
101negative regulation of lipase activity (GO:0060192)3.76437955
102sperm-egg recognition (GO:0035036)3.75448459
103complement activation (GO:0006956)3.73656470
104sexual reproduction (GO:0019953)3.73565309
105acetyl-CoA metabolic process (GO:0006084)3.73510972
106positive regulation of triglyceride lipase activity (GO:0061365)3.73393662
107positive regulation of lipoprotein lipase activity (GO:0051006)3.73393662
108cholesterol homeostasis (GO:0042632)3.72676842
109cytolysis (GO:0019835)3.72419557
110positive regulation of lipid catabolic process (GO:0050996)3.70871079
111very-low-density lipoprotein particle assembly (GO:0034379)3.69373622
112protein activation cascade (GO:0072376)3.69317733
113phospholipid homeostasis (GO:0055091)3.68922556
114hormone catabolic process (GO:0042447)3.68564010
115negative regulation of hemostasis (GO:1900047)3.67064680
116negative regulation of blood coagulation (GO:0030195)3.67064680
117sterol homeostasis (GO:0055092)3.66494551
118regulation of cholesterol homeostasis (GO:2000188)3.63105933
119short-chain fatty acid metabolic process (GO:0046459)3.62071092
120NAD biosynthetic process (GO:0009435)3.58092662
121response to nitrosative stress (GO:0051409)3.57601294
122plasma lipoprotein particle organization (GO:0071827)3.57599757
123nicotinamide nucleotide biosynthetic process (GO:0019359)3.57439539
124peptidyl-glutamic acid modification (GO:0018200)3.39348529
125organic cation transport (GO:0015695)3.37039960
126flavonoid metabolic process (GO:0009812)3.32699020
127negative regulation of wound healing (GO:0061045)3.32245205
128negative regulation of coagulation (GO:0050819)3.31558894
129S-adenosylmethionine metabolic process (GO:0046500)3.31069727
130spermatid nucleus differentiation (GO:0007289)3.26524328
131opsonization (GO:0008228)3.24485669
132response to mercury ion (GO:0046689)3.22830381
133response to pheromone (GO:0019236)3.22222749
134alkaloid metabolic process (GO:0009820)3.21856481
135single strand break repair (GO:0000012)3.16190880
136reproduction (GO:0000003)3.15646627
137multicellular organism reproduction (GO:0032504)3.09167300
138rRNA methylation (GO:0031167)3.03868849
139acute-phase response (GO:0006953)3.02961370
140heme transport (GO:0015886)3.02322898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.44039716
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.20000458
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.98098258
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.52454833
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.43338581
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.08549423
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.76088607
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.19033590
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.09240046
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.00202133
11* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.69047461
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32552609
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09460665
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03412604
15* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9821443
16* CTCF_27219007_Chip-Seq_Bcells_Human1.96804092
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95499960
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94759850
19ESR1_20079471_ChIP-ChIP_T-47D_Human1.88488746
20SMC4_20622854_ChIP-Seq_HELA_Human1.80380808
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79865159
22RAC3_21632823_ChIP-Seq_H3396_Human1.75577298
23ELF1_20517297_ChIP-Seq_JURKAT_Human1.67068953
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.63495785
25CLOCK_20551151_ChIP-Seq_293T_Human1.60977894
26ERA_21632823_ChIP-Seq_H3396_Human1.60610726
27HTT_18923047_ChIP-ChIP_STHdh_Human1.57384900
28ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53778374
29EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.47392493
30P68_20966046_ChIP-Seq_HELA_Human1.47378465
31CTCF_20526341_ChIP-Seq_ESCs_Human1.43571208
32* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41604117
33PHF8_20622854_ChIP-Seq_HELA_Human1.39323235
34GATA1_22025678_ChIP-Seq_K562_Human1.39029681
35E2F1_20622854_ChIP-Seq_HELA_Human1.36197022
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32107540
37CBP_20019798_ChIP-Seq_JUKART_Human1.32107540
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27424954
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26106078
40YY1_22570637_ChIP-Seq_MALME-3M_Human1.25512875
41BCOR_27268052_Chip-Seq_Bcells_Human1.23149015
42* TP63_22573176_ChIP-Seq_HFKS_Human1.21705529
43NANOG_20526341_ChIP-Seq_ESCs_Human1.21432559
44* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18754722
45BCL6_27268052_Chip-Seq_Bcells_Human1.18440307
46OCT4_20526341_ChIP-Seq_ESCs_Human1.16188745
47TP53_18474530_ChIP-ChIP_U2OS_Human1.15215651
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14767514
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14280164
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14280164
51MYC_19829295_ChIP-Seq_ESCs_Human1.13255291
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.12831180
53HNFA_21074721_ChIP-Seq_CACO-2_Human1.12482469
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.12285400
55SOX2_22085726_ChIP-Seq_NPCs_Mouse1.11433166
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11406019
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.11310408
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10616517
59* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09511141
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07068624
61SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06695169
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04643412
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03361926
64ERG_20517297_ChIP-Seq_VCAP_Human1.03033565
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.02925350
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01249044
67P300_27268052_Chip-Seq_Bcells_Human1.01011749
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00725121
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99548464
70SOX2_21211035_ChIP-Seq_LN229_Human0.98411525
71MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98186127
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97490679
73* SA1_27219007_Chip-Seq_Bcells_Human0.97426986
74ER_23166858_ChIP-Seq_MCF-7_Human0.97142568
75PHF8_20622853_ChIP-Seq_HELA_Human0.95555280
76* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.95376540
77RUNX1_27514584_Chip-Seq_MCF-7_Human0.94839687
78SOX11_22085726_ChIP-Seq_ESNs_Mouse0.94422199
79SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93972869
80DROSHA_22980978_ChIP-Seq_HELA_Human0.92681903
81SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92661141
82ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91220276
83JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.89959651
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89891832
85* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.89839952
86GATA3_21867929_ChIP-Seq_CD8_Mouse0.89735519
87RBPJ_21746931_ChIP-Seq_IB4_Human0.89345980
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87395242
89SMAD4_21741376_ChIP-Seq_EPCs_Human0.87306061
90* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87054836
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87048192
92GATA6_21074721_ChIP-Seq_CACO-2_Human0.86190613
93NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85821686
94CTCF_21964334_Chip-Seq_Bcells_Human0.85256427
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84880697
96NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83843996
97* TET1_21490601_ChIP-Seq_MESCs_Mouse0.83642586
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82066403
99ZNF263_19887448_ChIP-Seq_K562_Human0.80223575
100GATA4_25053715_ChIP-Seq_YYC3_Human0.78609712
101RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78248212
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77756899
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77617355
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75144234
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75064625
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74718904
107KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73312287
108* RARA_24833708_ChIP-Seq_LIVER_Mouse0.73011109
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69251316
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68986721
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.65970695
112RARB_24833708_ChIP-Seq_LIVER_Mouse0.65689042
113* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65391785
114ESR2_21235772_ChIP-Seq_MCF-7_Human0.64953772
115RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63977023
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.63949820
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.63619265
118IRF8_22096565_ChIP-ChIP_GC-B_Human0.62377935
119NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61116489
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61116489
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.58132125
122CEBPB_22108803_ChIP-Seq_LS180_Human0.56881048
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56729941
124* LXR_22292898_ChIP-Seq_THP-1_Human0.54021908
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52837725
126* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.52503927
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52322987
128FOXA1_25552417_ChIP-Seq_VCAP_Human0.52253049
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51902451
130MYC_19915707_ChIP-ChIP_AK7_Human0.51868300
131AR_20517297_ChIP-Seq_VCAP_Human0.51463075
132EGR1_19032775_ChIP-ChIP_M12_Human0.50748561
133FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49971361
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.49451820
135ESET_19884257_ChIP-Seq_ESCs_Mouse0.48748473
136P53_21459846_ChIP-Seq_SAOS-2_Human0.48480839
137CBP_21632823_ChIP-Seq_H3396_Human0.47914936
138GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.47428672
139STAT1_17558387_ChIP-Seq_HELA_Human0.47380716
140E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.46978078
141TAF15_26573619_Chip-Seq_HEK293_Human0.46969541
142ESR1_21235772_ChIP-Seq_MCF-7_Human0.46347666
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43690155
144PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43133285
145BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.42428671
146* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42008648
147MYC_27129775_Chip-Seq_CORNEA_Mouse0.42007358
148STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.41064068
149TAF2_19829295_ChIP-Seq_ESCs_Human0.39740800
150GATA1_19941826_ChIP-Seq_K562_Human0.39315379
151CDX2_20551321_ChIP-Seq_CACO-2_Human0.38830074
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.38798497
153GATA1_19941827_ChIP-Seq_MEL_Mouse0.38622574
154FOXO3_23340844_ChIP-Seq_DLD1_Human0.38442313
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38013995
156GATA6_25053715_ChIP-Seq_YYC3_Human0.37781836
157BCAT_22108803_ChIP-Seq_LS180_Human0.37741579
158SPI1_26923725_Chip-Seq_HPCs_Mouse0.37180442
159GATA2_19941826_ChIP-Seq_K562_Human0.37074338
160GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.36546673
161LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36404221
162* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.35931356
163PPAR_26484153_Chip-Seq_NCI-H1993_Human0.35598072
164NCOR_22424771_ChIP-Seq_293T_Human0.35436315
165FOXH1_21741376_ChIP-Seq_EPCs_Human0.33858786
166P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.33486118
167CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33267472
168CDX2_22108803_ChIP-Seq_LS180_Human0.33062141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.36545469
2MP0005360_urolithiasis7.60662104
3MP0005085_abnormal_gallbladder_physiolo6.52902016
4MP0005365_abnormal_bile_salt6.20719291
5MP0005410_abnormal_fertilization5.78284388
6MP0008875_abnormal_xenobiotic_pharmacok5.26597736
7MP0003806_abnormal_nucleotide_metabolis4.13326562
8MP0003252_abnormal_bile_duct3.94892384
9MP0010329_abnormal_lipoprotein_level3.57578525
10MP0009840_abnormal_foam_cell3.23227583
11MP0003195_calcinosis3.05927630
12MP0005083_abnormal_biliary_tract3.01431541
13MP0005332_abnormal_amino_acid2.82711643
14MP0001666_abnormal_nutrient_absorption2.58857169
15MP0003878_abnormal_ear_physiology2.51638189
16MP0005377_hearing/vestibular/ear_phenot2.51638189
17MP0003191_abnormal_cellular_cholesterol2.26481449
18MP0000609_abnormal_liver_physiology2.16226068
19MP0004019_abnormal_vitamin_homeostasis2.16034808
20MP0002118_abnormal_lipid_homeostasis2.09833413
21MP0003698_abnormal_male_reproductive2.03794459
22MP0003868_abnormal_feces_composition1.98054417
23MP0002138_abnormal_hepatobiliary_system1.94373860
24MP0005319_abnormal_enzyme/_coenzyme1.83700129
25MP0001929_abnormal_gametogenesis1.73507881
26MP0001764_abnormal_homeostasis1.68290976
27MP0002132_abnormal_respiratory_system1.65448993
28MP0005584_abnormal_enzyme/coenzyme_acti1.55151554
29MP0009697_abnormal_copulation1.51375321
30MP0002249_abnormal_larynx_morphology1.49751857
31MP0000678_abnormal_parathyroid_gland1.49248602
32MP0005451_abnormal_body_composition1.46698765
33MP0003011_delayed_dark_adaptation1.34069632
34MP0002282_abnormal_trachea_morphology1.30918349
35MP0003879_abnormal_hair_cell1.25263657
36MP0005647_abnormal_sex_gland1.24951843
37MP0003656_abnormal_erythrocyte_physiolo1.23501169
38MP0003186_abnormal_redox_activity1.22840064
39* MP0002161_abnormal_fertility/fecundity1.22473215
40MP0009643_abnormal_urine_homeostasis1.22401618
41MP0003705_abnormal_hypodermis_morpholog1.18210537
42MP0000598_abnormal_liver_morphology1.18129097
43MP0000604_amyloidosis1.04717954
44MP0002254_reproductive_system_inflammat1.00333905
45MP0009764_decreased_sensitivity_to0.99712307
46MP0009763_increased_sensitivity_to0.99610344
47MP0005670_abnormal_white_adipose0.98013939
48MP0000566_synostosis0.97736038
49MP0001348_abnormal_lacrimal_gland0.97588553
50MP0005379_endocrine/exocrine_gland_phen0.91234365
51MP0005636_abnormal_mineral_homeostasis0.89253990
52MP0005408_hypopigmentation0.86804748
53MP0010368_abnormal_lymphatic_system0.86440267
54MP0009642_abnormal_blood_homeostasis0.86303904
55MP0008469_abnormal_protein_level0.84618366
56MP0005187_abnormal_penis_morphology0.80649706
57MP0005376_homeostasis/metabolism_phenot0.79017580
58MP0006036_abnormal_mitochondrial_physio0.78903228
59MP0001661_extended_life_span0.78651103
60MP0009765_abnormal_xenobiotic_induced0.77387514
61MP0002078_abnormal_glucose_homeostasis0.76101360
62MP0009780_abnormal_chondrocyte_physiolo0.75538969
63MP0000534_abnormal_ureter_morphology0.75060550
64MP0002876_abnormal_thyroid_physiology0.74670471
65MP0000467_abnormal_esophagus_morphology0.74113059
66MP0002234_abnormal_pharynx_morphology0.72519694
67MP0004233_abnormal_muscle_weight0.72501948
68MP0002971_abnormal_brown_adipose0.71401043
69MP0005220_abnormal_exocrine_pancreas0.70184618
70MP0005084_abnormal_gallbladder_morpholo0.69695070
71MP0003690_abnormal_glial_cell0.69092632
72MP0005334_abnormal_fat_pad0.68067414
73MP0004130_abnormal_muscle_cell0.67980802
74MP0009053_abnormal_anal_canal0.67442900
75MP0005535_abnormal_body_temperature0.66431201
76MP0000639_abnormal_adrenal_gland0.66000587
77MP0003329_amyloid_beta_deposits0.64942511
78MP0005266_abnormal_metabolism0.64644024
79MP0002210_abnormal_sex_determination0.64521786
80MP0000653_abnormal_sex_gland0.63686791
81MP0001145_abnormal_male_reproductive0.63445196
82MP0001756_abnormal_urination0.59840014
83MP0005375_adipose_tissue_phenotype0.58283174
84MP0006035_abnormal_mitochondrial_morpho0.55598541
85MP0000003_abnormal_adipose_tissue0.55384032
86MP0003941_abnormal_skin_development0.54947031
87MP0002089_abnormal_postnatal_growth/wei0.54798083
88MP0003315_abnormal_perineum_morphology0.53793133
89MP0005448_abnormal_energy_balance0.53698566
90MP0003942_abnormal_urinary_system0.52447067
91MP0005423_abnormal_somatic_nervous0.51135275
92MP0003638_abnormal_response/metabolism_0.47420813
93MP0004272_abnormal_basement_membrane0.46952446
94MP0002822_catalepsy0.46761167
95MP0008874_decreased_physiological_sensi0.45937733
96MP0002928_abnormal_bile_duct0.45279412
97MP0005464_abnormal_platelet_physiology0.45246638
98MP0005248_abnormal_Harderian_gland0.44873244
99MP0002127_abnormal_cardiovascular_syste0.44567312
100MP0000462_abnormal_digestive_system0.43218392
101MP0008873_increased_physiological_sensi0.42969901
102MP0002136_abnormal_kidney_physiology0.42932570
103MP0005058_abnormal_lysosome_morphology0.42748466
104MP0002160_abnormal_reproductive_system0.42438374
105MP0003953_abnormal_hormone_level0.41941426
106MP0009384_cardiac_valve_regurgitation0.41905333
107MP0005666_abnormal_adipose_tissue0.41800962
108MP0009672_abnormal_birth_weight0.40379903
109MP0008872_abnormal_physiological_respon0.40264121
110MP0002697_abnormal_eye_size0.40020851
111MP0000681_abnormal_thyroid_gland0.39403242
112MP0004782_abnormal_surfactant_physiolog0.39143720
113* MP0005395_other_phenotype0.38264330
114MP0002168_other_aberrant_phenotype0.38197939
115MP0002837_dystrophic_cardiac_calcinosis0.37202853
116MP0003119_abnormal_digestive_system0.37121117
117MP0003936_abnormal_reproductive_system0.36570368
118MP0000955_abnormal_spinal_cord0.35992289
119MP0001944_abnormal_pancreas_morphology0.35544767
120MP0005166_decreased_susceptibility_to0.34551006
121MP0003632_abnormal_nervous_system0.33799979
122MP0003699_abnormal_female_reproductive0.33617891
123MP0000579_abnormal_nail_morphology0.33606297
124MP0003075_altered_response_to0.33491335
125MP0003436_decreased_susceptibility_to0.33283168
126MP0000516_abnormal_urinary_system0.33195614
127MP0000230_abnormal_systemic_arterial0.31586512
128MP0004381_abnormal_hair_follicle0.31278002
129MP0003724_increased_susceptibility_to0.31189565
130MP0009115_abnormal_fat_cell0.30456047
131MP0001243_abnormal_dermal_layer0.30114184
132MP0004883_abnormal_blood_vessel0.29849323
133MP0002090_abnormal_vision0.29097599
134MP0002970_abnormal_white_adipose0.28865337
135MP0000249_abnormal_blood_vessel0.28859415
136MP0002796_impaired_skin_barrier0.28663633
137MP0001881_abnormal_mammary_gland0.27127140
138MP0001853_heart_inflammation0.26709291
139MP0000427_abnormal_hair_cycle0.24051115
140MP0002060_abnormal_skin_morphology0.22504854
141MP0001845_abnormal_inflammatory_respons0.22486661
142MP0006082_CNS_inflammation0.21922830
143MP0002135_abnormal_kidney_morphology0.21133016
144MP0005164_abnormal_response_to0.20658530

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.62612863
2Deep venous thrombosis (HP:0002625)7.48232020
3Intrahepatic cholestasis (HP:0001406)7.31122761
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.90881075
5Prolonged partial thromboplastin time (HP:0003645)6.54530624
6Hypobetalipoproteinemia (HP:0003563)6.45838510
7Xanthomatosis (HP:0000991)6.31431365
8Hyperlipoproteinemia (HP:0010980)5.68171422
9Complement deficiency (HP:0004431)5.44382389
10Hypolipoproteinemia (HP:0010981)4.81381110
11Joint hemorrhage (HP:0005261)4.71713513
12Hyperammonemia (HP:0001987)4.68103645
13Epidermoid cyst (HP:0200040)4.60502978
14Abnormality of methionine metabolism (HP:0010901)4.50108986
15Abnormality of sulfur amino acid metabolism (HP:0004339)4.41278881
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.40696764
17Hyperglycinemia (HP:0002154)4.38652477
18Abnormality of the common coagulation pathway (HP:0010990)4.38198700
19Ketosis (HP:0001946)4.29630060
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.29231359
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.28081800
22Hypoalphalipoproteinemia (HP:0003233)4.22851347
23Fat malabsorption (HP:0002630)4.06890893
24Abnormality of pyrimidine metabolism (HP:0004353)4.03570679
25Abnormality of complement system (HP:0005339)3.95071899
26Hyperglycinuria (HP:0003108)3.91140127
27Abnormality of serine family amino acid metabolism (HP:0010894)3.90074168
28Abnormality of glycine metabolism (HP:0010895)3.90074168
29Osteomalacia (HP:0002749)3.78222086
30Hypoglycemic coma (HP:0001325)3.74060025
31Abnormality of the intrinsic pathway (HP:0010989)3.72934925
32Conjugated hyperbilirubinemia (HP:0002908)3.67458833
33Hypercholesterolemia (HP:0003124)3.63578353
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38646547
35Severe visual impairment (HP:0001141)3.31116060
36Abnormality of fatty-acid metabolism (HP:0004359)3.30953717
37Hyperbilirubinemia (HP:0002904)3.30527965
38Tubulointerstitial nephritis (HP:0001970)3.18868324
39Abnormality of serum amino acid levels (HP:0003112)3.13442171
40Delayed CNS myelination (HP:0002188)3.11948475
41Abnormality of nucleobase metabolism (HP:0010932)3.11403063
42Steatorrhea (HP:0002570)3.08126893
43Spontaneous abortion (HP:0005268)3.00200328
44Hepatocellular carcinoma (HP:0001402)2.98814394
45Ketoacidosis (HP:0001993)2.95622034
46Myocardial infarction (HP:0001658)2.92695585
47Hypochromic microcytic anemia (HP:0004840)2.92269868
48Skin nodule (HP:0200036)2.85668475
49Facial shape deformation (HP:0011334)2.79603108
50Potter facies (HP:0002009)2.79603108
51Metabolic acidosis (HP:0001942)2.74793296
52Chronic hepatic failure (HP:0100626)2.72104436
53Systemic lupus erythematosus (HP:0002725)2.71500482
54Abnormality of purine metabolism (HP:0004352)2.65319255
55Lethargy (HP:0001254)2.61363031
56Resting tremor (HP:0002322)2.58217515
57Vascular calcification (HP:0004934)2.57299025
58Asymmetric septal hypertrophy (HP:0001670)2.55838645
59Hyperphosphaturia (HP:0003109)2.53870932
60Spastic diplegia (HP:0001264)2.53321298
61Dicarboxylic aciduria (HP:0003215)2.52592223
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52592223
63Glycosuria (HP:0003076)2.51408273
64Abnormality of urine glucose concentration (HP:0011016)2.51408273
65Acanthocytosis (HP:0001927)2.48249622
66Mitral stenosis (HP:0001718)2.47173730
67Cerebral edema (HP:0002181)2.46703990
68Gout (HP:0001997)2.46514053
69Abnormal gallbladder morphology (HP:0012437)2.45076181
70Neonatal onset (HP:0003623)2.43355506
71Irritability (HP:0000737)2.42312234
72Reduced antithrombin III activity (HP:0001976)2.40413024
73Glomerulonephritis (HP:0000099)2.40124767
74Cholelithiasis (HP:0001081)2.38634060
75Hypoglycemic seizures (HP:0002173)2.38332629
76Infertility (HP:0000789)2.37668200
77Cholecystitis (HP:0001082)2.33257664
78Abnormal gallbladder physiology (HP:0012438)2.33257664
79Male infertility (HP:0003251)2.32710663
80Recurrent gram-negative bacterial infections (HP:0005420)2.30529273
81Cardiovascular calcification (HP:0011915)2.28619690
82Hyperuricemia (HP:0002149)2.25561766
83Increased purine levels (HP:0004368)2.25561766
84Amyloidosis (HP:0011034)2.25113371
85Focal segmental glomerulosclerosis (HP:0000097)2.22515923
86Renovascular hypertension (HP:0100817)2.19550479
87Malnutrition (HP:0004395)2.18190148
88Brushfield spots (HP:0001088)2.17889234
89Abnormality of the Achilles tendon (HP:0005109)2.17298550
90Retinal atrophy (HP:0001105)2.15901736
91Esophageal varix (HP:0002040)2.13980276
92Impulsivity (HP:0100710)2.13536402
93Enlarged kidneys (HP:0000105)2.13467214
94Abnormal urine phosphate concentration (HP:0012599)2.12395481
95Gingival bleeding (HP:0000225)2.09310308
96Late onset (HP:0003584)2.08995644
97Sensorimotor neuropathy (HP:0007141)2.08971437
98Pancreatitis (HP:0001733)2.08873018
99Unilateral renal agenesis (HP:0000122)2.08642332
100Menorrhagia (HP:0000132)2.07464091
101Vomiting (HP:0002013)2.05099426
102Azoospermia (HP:0000027)2.04880764
103Thrombophlebitis (HP:0004418)2.03131237
104Glomerulosclerosis (HP:0000096)2.00369203
105Abnormality of the gallbladder (HP:0005264)2.00012831
106Absent/shortened dynein arms (HP:0200106)1.99433113
107Dynein arm defect of respiratory motile cilia (HP:0012255)1.99433113
108Hemorrhage of the eye (HP:0011885)1.98806170
109Opisthotonus (HP:0002179)1.98788048
110Bony spicule pigmentary retinopathy (HP:0007737)1.97223363
111Poikilocytosis (HP:0004447)1.96679687
112Progressive sensorineural hearing impairment (HP:0000408)1.95637278
113Rickets (HP:0002748)1.93851840
114Hyperinsulinemic hypoglycemia (HP:0000825)1.93582789
115Bifid scrotum (HP:0000048)1.92897309
116Alkalosis (HP:0001948)1.92807427
117Generalized aminoaciduria (HP:0002909)1.92610423
118Abnormal cartilage morphology (HP:0002763)1.89951455
119Status epilepticus (HP:0002133)1.87472311
120Hydroxyprolinuria (HP:0003080)1.86631538
121Abnormality of proline metabolism (HP:0010907)1.86631538
122Abnormality of transition element cation homeostasis (HP:0011030)1.85012128
123Hypophosphatemic rickets (HP:0004912)1.84917435
124Abnormality of iron homeostasis (HP:0011031)1.83918798
125Abnormal enzyme/coenzyme activity (HP:0012379)1.80709952
126Renal cortical cysts (HP:0000803)1.78788882
127Elevated hepatic transaminases (HP:0002910)1.78751525
128Abnormality of vitamin metabolism (HP:0100508)1.75932673
129Nephritis (HP:0000123)1.74651936
130Hyperglycemia (HP:0003074)1.73220429
131Stage 5 chronic kidney disease (HP:0003774)1.70063772
132Renal dysplasia (HP:0000110)1.69819324
133Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69059219
134Widely patent fontanelles and sutures (HP:0004492)1.66837913
135Attenuation of retinal blood vessels (HP:0007843)1.65738024
136Abnormality of the aortic arch (HP:0012303)1.65597960
137Hyperkalemia (HP:0002153)1.64059491
138Proximal tubulopathy (HP:0000114)1.61332287
139Amelogenesis imperfecta (HP:0000705)1.59995609
140Reticulocytosis (HP:0001923)1.58742946
141Double outlet right ventricle (HP:0001719)1.58472706
142Congenital malformation of the right heart (HP:0011723)1.58472706
143Bell-shaped thorax (HP:0001591)1.57423558
144Hypophosphatemia (HP:0002148)1.56525103
145Abnormal spermatogenesis (HP:0008669)1.56048454

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.20174384
2PLK45.64175667
3TESK15.27138293
4FGFR44.56159632
5SIK14.49812994
6ERN14.42040650
7STK383.22118288
8ERBB43.02028328
9DDR22.96923979
10TAOK32.87023574
11INSRR2.86212566
12MAP2K42.55439838
13PRKD32.41841769
14BRD42.37473605
15PKN22.31469128
16PNCK2.08169567
17LATS12.00833889
18MST1R1.99493727
19MAP4K21.99203191
20TRIB31.93780359
21MAPK111.89433784
22FLT31.83773750
23CDK121.77111473
24DAPK21.66349680
25PTK61.61257011
26PLK21.60783131
27CDK71.58054329
28TYK21.55361705
29PIK3CG1.55243169
30ABL21.49283415
31FGFR21.43357969
32EPHA21.40718269
33MAP3K91.35206282
34LMTK21.25244160
35NEK91.25201417
36FRK1.22511397
37MUSK1.19162082
38MAP3K21.18653627
39PINK11.17248518
40JAK21.16766040
41MAP3K71.15103621
42KDR1.10627178
43ERBB21.08964931
44PRKAA21.08273740
45MAP3K101.07291112
46STK38L1.06138104
47GRK61.01863172
48MAPK40.99838286
49PRKCZ0.97043551
50KSR20.96656302
51MAP2K30.96512566
52TBK10.93838668
53MAPK150.93460120
54MAP2K70.93070507
55MET0.91642609
56EPHB10.91636489
57NEK60.88735419
58JAK10.87733053
59RPS6KA20.82261351
60MAP3K30.81528721
61MAP3K110.80940641
62CDK60.80806304
63MAPK120.80493707
64TYRO30.79238283
65PRKACG0.78101686
66ICK0.77901292
67MAP3K140.77466453
68RIPK10.75858337
69DYRK20.73230179
70CAMK2G0.72788230
71NTRK30.71911539
72MARK10.71246471
73MAP2K60.70544352
74GSK3A0.70479752
75MYLK0.69844949
76DYRK1B0.69440007
77CSK0.68935656
78ARAF0.67632555
79SGK30.67006761
80WNK10.66331471
81CAMK1D0.65531360
82AKT30.64671370
83PRKAA10.63535061
84PTK20.63435101
85PRKG20.62851542
86CSNK1G10.62339809
87BMPR1B0.61080115
88TIE10.60609966
89MAPK70.60447140
90BRAF0.60318124
91EPHA30.58928522
92PRKG10.58871562
93NTRK10.54523145
94RPS6KA10.53792956
95PDPK10.52841961
96FER0.52519752
97CDK40.52236658
98LATS20.51534964
99WNK40.50983150
100FGFR30.50980395
101EEF2K0.50334233
102EPHA40.48952565
103SGK20.48862099
104RET0.48477834
105MTOR0.46824306
106IKBKE0.46728030
107CSF1R0.45774610
108PRKCG0.45682737
109PRKCQ0.44875973
110MAP3K50.44283803
111MAP2K10.43588101
112CSNK1G20.43467779
113GSK3B0.42552652
114CSNK1G30.41701826
115PKN10.41466198
116TESK20.41464794
117PDK30.41022153
118PDK40.41022153
119IGF1R0.40570313
120TAOK20.40321011
121BRSK10.38942923
122IRAK30.38598116
123RPS6KA50.38474989
124AKT20.38083006
125GRK10.38078726
126TGFBR20.38036938
127EGFR0.38008502
128CDK30.37893224
129SGK2230.36846218
130SGK4940.36846218
131CSNK1A1L0.36566461
132MAPK10.36086534
133MAP3K60.35973308
134CDK10.34507686
135CSNK1D0.34135666
136CDK20.33604203
137MAPKAPK50.33197607
138CDK80.32094810
139ROCK10.32076678
140CAMK40.31083530
141PDK10.30093984
142MAPK80.29982884
143PAK30.29193402
144STK160.28006994
145MAP2K20.27011096
146SIK20.26509683
147PDGFRA0.25326355
148MAP3K10.24981351
149CAMK1G0.24816941
150PRKCA0.24391008
151PBK0.23925781
152MAP3K40.23864241
153BMX0.22912161

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.56348605
2Nitrogen metabolism_Homo sapiens_hsa009103.61774215
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.53237758
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33552444
5Arginine biosynthesis_Homo sapiens_hsa002203.17228078
6Complement and coagulation cascades_Homo sapiens_hsa046102.74870600
7Tryptophan metabolism_Homo sapiens_hsa003802.69479243
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66831982
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58795972
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58645844
11Fatty acid degradation_Homo sapiens_hsa000712.46573029
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35404020
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23173879
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13853817
15Butanoate metabolism_Homo sapiens_hsa006502.12004051
16Peroxisome_Homo sapiens_hsa041462.05258305
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.98233732
18Chemical carcinogenesis_Homo sapiens_hsa052041.94089738
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92409344
20Propanoate metabolism_Homo sapiens_hsa006401.89281820
21Histidine metabolism_Homo sapiens_hsa003401.88274562
22PPAR signaling pathway_Homo sapiens_hsa033201.86853326
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.79915885
24Caffeine metabolism_Homo sapiens_hsa002321.79175406
25Fatty acid metabolism_Homo sapiens_hsa012121.79113183
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.75219274
27Staphylococcus aureus infection_Homo sapiens_hsa051501.69508235
28Retinol metabolism_Homo sapiens_hsa008301.69502095
29beta-Alanine metabolism_Homo sapiens_hsa004101.68561354
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67015541
31Selenocompound metabolism_Homo sapiens_hsa004501.60170809
32Phenylalanine metabolism_Homo sapiens_hsa003601.59870634
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55708016
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55223534
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50915721
36Bile secretion_Homo sapiens_hsa049761.49433869
37Tyrosine metabolism_Homo sapiens_hsa003501.44511846
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.40029547
39Pyruvate metabolism_Homo sapiens_hsa006201.37558653
40Sulfur metabolism_Homo sapiens_hsa009201.32080233
41Fatty acid elongation_Homo sapiens_hsa000621.30443391
42Starch and sucrose metabolism_Homo sapiens_hsa005001.25698107
43Biosynthesis of amino acids_Homo sapiens_hsa012301.25313319
44Folate biosynthesis_Homo sapiens_hsa007901.20185985
45Steroid biosynthesis_Homo sapiens_hsa001001.18306086
46ABC transporters_Homo sapiens_hsa020101.16488240
47Fat digestion and absorption_Homo sapiens_hsa049751.13483415
48Carbon metabolism_Homo sapiens_hsa012001.11298661
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06330584
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.97687523
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.96888516
52Arginine and proline metabolism_Homo sapiens_hsa003300.96876184
53Sulfur relay system_Homo sapiens_hsa041220.94695004
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92907024
55Vitamin B6 metabolism_Homo sapiens_hsa007500.89926238
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87118448
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85777840
58Vitamin digestion and absorption_Homo sapiens_hsa049770.85457832
59Lysine degradation_Homo sapiens_hsa003100.83994472
60One carbon pool by folate_Homo sapiens_hsa006700.74011649
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69484660
62Glycerolipid metabolism_Homo sapiens_hsa005610.67210466
63Glutathione metabolism_Homo sapiens_hsa004800.64716417
64Pentose phosphate pathway_Homo sapiens_hsa000300.54832071
65Fatty acid biosynthesis_Homo sapiens_hsa000610.54271751
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45456391
67* Metabolic pathways_Homo sapiens_hsa011000.45141504
68Prion diseases_Homo sapiens_hsa050200.38213929
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35376876
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23809005
71Insulin resistance_Homo sapiens_hsa049310.23476456
72Fructose and mannose metabolism_Homo sapiens_hsa000510.22735499
73Linoleic acid metabolism_Homo sapiens_hsa005910.22680720
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.22235396
75Galactose metabolism_Homo sapiens_hsa000520.21051661
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19905660
77Type II diabetes mellitus_Homo sapiens_hsa049300.17196788
78Glucagon signaling pathway_Homo sapiens_hsa049220.11717521
79Hedgehog signaling pathway_Homo sapiens_hsa043400.09253151
80Olfactory transduction_Homo sapiens_hsa047400.09031023
81* Glycerophospholipid metabolism_Homo sapiens_hsa005640.08741824
82Sphingolipid metabolism_Homo sapiens_hsa006000.06335217
83AMPK signaling pathway_Homo sapiens_hsa041520.03742230
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2553602
85Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2253612
86Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2249112
87Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2163767
88Amoebiasis_Homo sapiens_hsa05146-0.2102595
89Renin-angiotensin system_Homo sapiens_hsa04614-0.2041461
90Hepatitis C_Homo sapiens_hsa05160-0.1922455
91Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1898135
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1897261
93Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1815767
94Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1788022
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1787332
96African trypanosomiasis_Homo sapiens_hsa05143-0.1711856
97Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1571932
98Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1434860
99Regulation of autophagy_Homo sapiens_hsa04140-0.1407554
100Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.1168527
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0988215
102Insulin signaling pathway_Homo sapiens_hsa04910-0.0952169
103Protein digestion and absorption_Homo sapiens_hsa04974-0.0755365
104Tight junction_Homo sapiens_hsa04530-0.0679229
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0649109
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0586163
107ECM-receptor interaction_Homo sapiens_hsa04512-0.0564565
108Serotonergic synapse_Homo sapiens_hsa04726-0.0562011
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0299595
110Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0221260
111N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0216934

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