ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-phenylalanine catabolic process (GO:0006559)	7.24154940
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.24154940
3	L-phenylalanine metabolic process (GO:0006558)	6.84247802
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.84247802
5	aromatic amino acid family catabolic process (GO:0009074)	6.58878307
6	glyoxylate metabolic process (GO:0046487)	6.05947865
7	tryptophan catabolic process (GO:0006569)	5.99122271
8	indole-containing compound catabolic process (GO:0042436)	5.99122271
9	indolalkylamine catabolic process (GO:0046218)	5.99122271
10	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.95518634
11	kynurenine metabolic process (GO:0070189)	5.81013287
12	bile acid biosynthetic process (GO:0006699)	5.73467616
13	synaptic vesicle docking involved in exocytosis (GO:0016081)	5.65301366
14	tryptophan metabolic process (GO:0006568)	5.59809659
15	L-amino acid import (GO:0043092)	5.58556168
16	urea metabolic process (GO:0019627)	5.56979057
17	urea cycle (GO:0000050)	5.56979057
18	cellular potassium ion homeostasis (GO:0030007)	5.55332522
19	alpha-linolenic acid metabolic process (GO:0036109)	5.30076333
20	glutamate secretion (GO:0014047)	5.29621046
21	high-density lipoprotein particle remodeling (GO:0034375)	5.27595002
22	synaptic vesicle maturation (GO:0016188)	5.26350794
23	sulfur amino acid catabolic process (GO:0000098)	5.20179266
24	amino-acid betaine metabolic process (GO:0006577)	5.18003801
25	amino acid import (GO:0043090)	5.17955962
26	cysteine metabolic process (GO:0006534)	5.16331759
27	amine catabolic process (GO:0009310)	5.15896306
28	cellular biogenic amine catabolic process (GO:0042402)	5.15896306
29	central nervous system myelination (GO:0022010)	5.14256064
30	axon ensheathment in central nervous system (GO:0032291)	5.14256064
31	nitrogen cycle metabolic process (GO:0071941)	5.08327622
32	sodium ion export (GO:0071436)	5.07287867
33	serine family amino acid catabolic process (GO:0009071)	5.04645201
34	complement activation, alternative pathway (GO:0006957)	5.03723909
35	regulation of protein activation cascade (GO:2000257)	5.03165682
36	negative regulation of fibrinolysis (GO:0051918)	5.02652891
37	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.93556906
38	protein carboxylation (GO:0018214)	4.88621902
39	peptidyl-glutamic acid carboxylation (GO:0017187)	4.88621902
40	regulation of fibrinolysis (GO:0051917)	4.87139064
41	homocysteine metabolic process (GO:0050667)	4.85338379
42	bile acid metabolic process (GO:0008206)	4.84275001
43	regulation of cholesterol esterification (GO:0010872)	4.81326766
44	protein-lipid complex remodeling (GO:0034368)	4.75224615
45	macromolecular complex remodeling (GO:0034367)	4.75224615
46	plasma lipoprotein particle remodeling (GO:0034369)	4.75224615
47	aromatic amino acid family metabolic process (GO:0009072)	4.73893426
48	regulation of complement activation (GO:0030449)	4.73732983
49	reverse cholesterol transport (GO:0043691)	4.71513537
50	synaptic vesicle exocytosis (GO:0016079)	4.69309853
51	tyrosine metabolic process (GO:0006570)	4.65584811
52	postsynaptic membrane organization (GO:0001941)	4.59417647
53	alpha-amino acid catabolic process (GO:1901606)	4.56849018
54	regulation of synaptic vesicle exocytosis (GO:2000300)	4.53965863
55	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.53632941
56	regulation of triglyceride catabolic process (GO:0010896)	4.49875010
57	low-density lipoprotein particle remodeling (GO:0034374)	4.45459023
58	glutamate metabolic process (GO:0006536)	4.45255357
59	potassium ion import (GO:0010107)	4.44743108
60	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.33873493
61	lysine catabolic process (GO:0006554)	4.33798424
62	lysine metabolic process (GO:0006553)	4.33798424
63	dicarboxylic acid biosynthetic process (GO:0043650)	4.33702629
64	locomotory exploration behavior (GO:0035641)	4.27414534
65	coenzyme catabolic process (GO:0009109)	4.27329415
66	potassium ion homeostasis (GO:0055075)	4.24291312
67	acylglycerol homeostasis (GO:0055090)	4.24202826
68	triglyceride homeostasis (GO:0070328)	4.24202826
69	neurotransmitter uptake (GO:0001504)	4.23914342
70	cellular amino acid catabolic process (GO:0009063)	4.23203665
71	carnitine metabolic process (GO:0009437)	4.21549353
72	cellular modified amino acid catabolic process (GO:0042219)	4.20705524
73	phospholipid efflux (GO:0033700)	4.20446740
74	indolalkylamine metabolic process (GO:0006586)	4.20404270
75	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	4.19607390
76	neurotransmitter secretion (GO:0007269)	4.18101130
77	negative regulation of cholesterol transport (GO:0032375)	4.14457198
78	negative regulation of sterol transport (GO:0032372)	4.14457198
79	cellular ketone body metabolic process (GO:0046950)	4.11693662
80	bile acid and bile salt transport (GO:0015721)	4.10975807
81	imidazole-containing compound metabolic process (GO:0052803)	4.10288201
82	regulation of synaptic vesicle transport (GO:1902803)	4.08776460
83	neuronal ion channel clustering (GO:0045161)	4.04571453
84	cholesterol efflux (GO:0033344)	4.02525688
85	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.99463737
86	very-low-density lipoprotein particle assembly (GO:0034379)	3.98076425
87	cellular glucuronidation (GO:0052695)	3.97828013
88	plasma lipoprotein particle clearance (GO:0034381)	3.95312647
89	serine family amino acid metabolic process (GO:0009069)	3.94775530
90	cellular sodium ion homeostasis (GO:0006883)	3.94651162
91	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.93832670
92	plasma lipoprotein particle assembly (GO:0034377)	3.91232137
93	glycine metabolic process (GO:0006544)	3.89414055
94	arginine metabolic process (GO:0006525)	3.88543112
95	exploration behavior (GO:0035640)	3.85286978
96	vocalization behavior (GO:0071625)	3.83921647
97	gamma-aminobutyric acid transport (GO:0015812)	3.83712225
98	phospholipid homeostasis (GO:0055091)	3.82884880
99	ethanol oxidation (GO:0006069)	3.82654249
100	neuronal action potential propagation (GO:0019227)	3.81898468
101	benzene-containing compound metabolic process (GO:0042537)	3.78265017
102	drug catabolic process (GO:0042737)	3.77037786
103	serine family amino acid biosynthetic process (GO:0009070)	3.73787361
104	C4-dicarboxylate transport (GO:0015740)	3.71801095
105	plasma lipoprotein particle organization (GO:0071827)	3.71662719
106	neuron cell-cell adhesion (GO:0007158)	3.71202248
107	regulation of neuronal synaptic plasticity (GO:0048168)	3.69902022
108	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.68896277
109	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.66771967
110	acidic amino acid transport (GO:0015800)	3.66559018
111	organic acid catabolic process (GO:0016054)	3.63882304
112	carboxylic acid catabolic process (GO:0046395)	3.63882304
113	neurotransmitter transport (GO:0006836)	3.63004524
114	cerebellar granule cell differentiation (GO:0021707)	3.60012091
115	regulation of bile acid biosynthetic process (GO:0070857)	3.59354673
116	negative regulation of lipase activity (GO:0060192)	3.57989299
117	ketone body metabolic process (GO:1902224)	3.53924381
118	complement activation, classical pathway (GO:0006958)	3.53786555
119	fibrinolysis (GO:0042730)	3.52985018
120	exogenous drug catabolic process (GO:0042738)	3.52419873
121	blood coagulation, intrinsic pathway (GO:0007597)	3.52168470
122	omega-hydroxylase P450 pathway (GO:0097267)	3.51721691
123	presynaptic membrane assembly (GO:0097105)	3.51492489
124	complement activation (GO:0006956)	3.50390010
125	cytolysis (GO:0019835)	3.49221760
126	cofactor catabolic process (GO:0051187)	3.49201501
127	neurotransmitter-gated ion channel clustering (GO:0072578)	3.48588063
128	protein activation cascade (GO:0072376)	3.48478734
129	protein-lipid complex assembly (GO:0065005)	3.48111148
130	protein-lipid complex subunit organization (GO:0071825)	3.47887268
131	2-oxoglutarate metabolic process (GO:0006103)	3.47035708
132	short-chain fatty acid metabolic process (GO:0046459)	3.46811214
133	uronic acid metabolic process (GO:0006063)	3.46719778
134	glucuronate metabolic process (GO:0019585)	3.46719778
135	urate metabolic process (GO:0046415)	3.45922618
136	regulation of neurotransmitter levels (GO:0001505)	3.43902368
137	epoxygenase P450 pathway (GO:0019373)	3.43590168
138	positive regulation of lipid catabolic process (GO:0050996)	3.42861824
139	presynaptic membrane organization (GO:0097090)	3.42480764
140	acetyl-CoA metabolic process (GO:0006084)	3.42426994
141	cholesterol homeostasis (GO:0042632)	3.41668270
142	aldehyde catabolic process (GO:0046185)	3.41529426
143	cell communication by electrical coupling (GO:0010644)	3.34984282
144	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.34240753
145	synaptic transmission, glutamatergic (GO:0035249)	3.32026758
146	regulation of long-term neuronal synaptic plasticity (GO:0048169)	3.28868575
147	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.23483116
148	L-glutamate transport (GO:0015813)	3.20622910
149	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.15592973
150	positive regulation of synapse maturation (GO:0090129)	3.15427817
151	regulation of glutamate receptor signaling pathway (GO:1900449)	3.05500439
152	positive regulation of dendritic spine development (GO:0060999)	3.02651268
153	neuron-neuron synaptic transmission (GO:0007270)	3.00628831
154	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.99161169
155	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.96959553
156	protein localization to synapse (GO:0035418)	2.94460023
157	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.92430864
158	regulation of synaptic plasticity (GO:0048167)	2.90561057
159	regulation of neurotransmitter secretion (GO:0046928)	2.90235496
160	regulation of synapse structural plasticity (GO:0051823)	2.89360396
161	regulation of neurotransmitter transport (GO:0051588)	2.86949344
162	positive regulation of membrane potential (GO:0045838)	2.85789015
163	glutamate receptor signaling pathway (GO:0007215)	2.84909428
164	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.83996529
165	regulation of female receptivity (GO:0045924)	2.82210361
166	neuromuscular process controlling balance (GO:0050885)	2.81723528
167	synaptic vesicle endocytosis (GO:0048488)	2.81014250
168	long-term synaptic potentiation (GO:0060291)	2.80892748
169	regulation of voltage-gated calcium channel activity (GO:1901385)	2.79015999
170	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.77640278
171	oxidative demethylation (GO:0070989)	2.76978992
172	drug metabolic process (GO:0017144)	2.76373136
173	auditory behavior (GO:0031223)	2.74913683
174	sodium ion homeostasis (GO:0055078)	2.74054719
175	regulation of excitatory postsynaptic membrane potential (GO:0060079)	2.68369314
176	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.67142686
177	steroid catabolic process (GO:0006706)	2.65937383
178	positive regulation of neurotransmitter transport (GO:0051590)	2.65403259
179	regulation of neurotransmitter uptake (GO:0051580)	2.64521607

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	7.28019456
2	PPARA_22158963_ChIP-Seq_LIVER_Mouse	6.10938595
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.03978596
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	5.73311939
5	EZH2_22144423_ChIP-Seq_EOC_Human	4.84998593
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.70900999
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.86700030
8	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	3.78408044
9	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.62160011
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.25360448
11	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.74159695
12	DROSHA_22980978_ChIP-Seq_HELA_Human	2.47192262
13	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.45959629
14	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.33903302
15	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.13788272
16	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.13788272
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.12431858
18	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.09617767
19	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.04890899
20	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.02233951
21	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.02106947
22	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	10.4464250
23	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.99933968
24	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.96432789
25	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.95150961
26	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.91016346
27	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.89281063
28	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.67425972
29	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.63968211
30	HTT_18923047_ChIP-ChIP_STHdh_Human	1.63525751
31	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.59210833
32	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.54471059
33	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.38203041
34	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.35474762
35	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.35191860
36	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.35109180
37	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.31015808
38	GBX2_23144817_ChIP-Seq_PC3_Human	1.28698998
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28619028
40	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.22857785
41	CLOCK_20551151_ChIP-Seq_293T_Human	1.22399463
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.21864424
43	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.21809792
44	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.17300940
45	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.14944910
46	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.14299227
47	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.13204523
48	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.13061144
49	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.09182030
50	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.07925950
51	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.07917805
52	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.06412357
53	AR_19668381_ChIP-Seq_PC3_Human	1.06293329
54	TCF4_23295773_ChIP-Seq_U87_Human	1.04716872
55	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02511908
56	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.99837279
57	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.99701856
58	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.99492508
59	STAT3_23295773_ChIP-Seq_U87_Human	0.98330295
60	CTCF_27219007_Chip-Seq_Bcells_Human	0.97306458
61	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.97304751
62	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.97304751
63	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.96895736
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95251487
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.95038418
66	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.94614764
67	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.94386161
68	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.94299565
69	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.92827712
70	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.92644329
71	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92418154
72	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.90580186
73	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.89813708
74	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.87826028
75	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.87100118
76	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.86900058
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.86474561
78	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.86048032
79	TAF15_26573619_Chip-Seq_HEK293_Human	0.85453180
80	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.84056359
81	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.83399553
82	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.82995392
83	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.82576322
84	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.82276433
85	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.81769469
86	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.80795947
87	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.79946620
88	RNF2_27304074_Chip-Seq_NSC_Mouse	0.79789859
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.79529104
90	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.78939470
91	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.78913710
92	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.78534658
93	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.78028227
94	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.77243853
95	BCAT_22108803_ChIP-Seq_LS180_Human	0.76745399
96	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.76625422
97	GATA1_22025678_ChIP-Seq_K562_Human	0.75109982
98	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.73290401
99	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.71011992
100	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.70686740
101	GATA4_25053715_ChIP-Seq_YYC3_Human	0.69475562
102	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.69122470
103	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.68781733
104	AR_21572438_ChIP-Seq_LNCaP_Human	0.67045565
105	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.66823741
106	CBP_21632823_ChIP-Seq_H3396_Human	0.65835570
107	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.63310327
108	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.63301769
109	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.63244335
110	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.61998550
111	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.61950782
112	CEBPB_22108803_ChIP-Seq_LS180_Human	0.60697325
113	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.60415483
114	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.59989628
115	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.59851068
116	AR_20517297_ChIP-Seq_VCAP_Human	0.58965862
117	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.58645166
118	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.58502889
119	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.57368395
120	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.56814498
121	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.56278077
122	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.56022619
123	RXR_22108803_ChIP-Seq_LS180_Human	0.55216673
124	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.54937212
125	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.53782875
126	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.53680755
127	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.53551343
128	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.53481674
129	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.52852170
130	CDX2_22108803_ChIP-Seq_LS180_Human	0.52680131
131	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.52454702
132	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.52340861
133	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.51976911
134	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.51732720
135	ZNF263_19887448_ChIP-Seq_K562_Human	0.51333327
136	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.50852014
137	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.50750696
138	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.50454832
139	MYC_19915707_ChIP-ChIP_AK7_Human	0.50406372
140	EGR1_19032775_ChIP-ChIP_M12_Human	0.50236864
141	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.50049421
142	SMAD4_21799915_ChIP-Seq_A2780_Human	0.49932210
143	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.49714589
144	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.49621131
145	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.49581298
146	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.49347240
147	REST_21632747_ChIP-Seq_MESCs_Mouse	0.49232291
148	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.48773256
149	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.48736868
150	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.48678033
151	P300_19829295_ChIP-Seq_ESCs_Human	0.48308825
152	AR_25329375_ChIP-Seq_VCAP_Human	0.47896328
153	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.47832128
154	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.47733801
155	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.47653841
156	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.47459783
157	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.47375389
158	GATA1_19941826_ChIP-Seq_K562_Human	0.47182849

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	7.82837576
2	MP0005360_urolithiasis	7.31741966
3	MP0005085_abnormal_gallbladder_physiolo	6.31152755
4	MP0005365_abnormal_bile_salt	5.92374032
5	MP0004859_abnormal_synaptic_plasticity	4.80660734
6	MP0008875_abnormal_xenobiotic_pharmacok	4.79882008
7	MP0005423_abnormal_somatic_nervous	4.13177239
8	MP0003880_abnormal_central_pattern	4.12469496
9	MP0003252_abnormal_bile_duct	3.90154093
10	MP0003806_abnormal_nucleotide_metabolis	3.76428215
11	MP0010329_abnormal_lipoprotein_level	3.63588705
12	MP0003635_abnormal_synaptic_transmissio	3.32015799
13	MP0002064_seizures	3.30476156
14	MP0009745_abnormal_behavioral_response	3.02851845
15	MP0001486_abnormal_startle_reflex	2.94479835
16	MP0005670_abnormal_white_adipose	2.91182181
17	MP0005332_abnormal_amino_acid	2.90022209
18	MP0003195_calcinosis	2.84415269
19	MP0009840_abnormal_foam_cell	2.84220655
20	MP0005083_abnormal_biliary_tract	2.81400108
21	MP0002272_abnormal_nervous_system	2.75198584
22	MP0002063_abnormal_learning/memory/cond	2.68867547
23	MP0005451_abnormal_body_composition	2.58273192
24	MP0001666_abnormal_nutrient_absorption	2.56385793
25	MP0002734_abnormal_mechanical_nocicepti	2.44685698
26	MP0001968_abnormal_touch/_nociception	2.41334739
27	MP0003879_abnormal_hair_cell	2.34184680
28	MP0009046_muscle_twitch	2.30972869
29	MP0002572_abnormal_emotion/affect_behav	2.27986990
30	MP0004019_abnormal_vitamin_homeostasis	2.11462129
31	MP0002118_abnormal_lipid_homeostasis	2.10140497
32	MP0000609_abnormal_liver_physiology	2.02991464
33	MP0003868_abnormal_feces_composition	1.97242879
34	MP0009780_abnormal_chondrocyte_physiolo	1.96530086
35	MP0001501_abnormal_sleep_pattern	1.96251969
36	MP0002736_abnormal_nociception_after	1.93854336
37	MP0002735_abnormal_chemical_nociception	1.86988940
38	MP0000920_abnormal_myelination	1.85689320
39	MP0003191_abnormal_cellular_cholesterol	1.82972997
40	MP0008569_lethality_at_weaning	1.82930211
41	MP0001984_abnormal_olfaction	1.79397949
42	MP0001970_abnormal_pain_threshold	1.76741810
43	MP0005319_abnormal_enzyme/_coenzyme	1.74546528
44	MP0009697_abnormal_copulation	1.70541740
45	MP0002733_abnormal_thermal_nociception	1.62175803
46	MP0005584_abnormal_enzyme/coenzyme_acti	1.60142403
47	MP0001986_abnormal_taste_sensitivity	1.59695617
48	MP0002638_abnormal_pupillary_reflex	1.57876553
49	MP0002138_abnormal_hepatobiliary_system	1.57699610
50	MP0001905_abnormal_dopamine_level	1.56477123
51	MP0002067_abnormal_sensory_capabilities	1.44446532
52	MP0001764_abnormal_homeostasis	1.43234462
53	MP0002557_abnormal_social/conspecific_i	1.40117504
54	MP0005551_abnormal_eye_electrophysiolog	1.37559740
55	MP0005377_hearing/vestibular/ear_phenot	1.37190803
56	MP0003878_abnormal_ear_physiology	1.37190803
57	MP0003690_abnormal_glial_cell	1.35266865
58	MP0003705_abnormal_hypodermis_morpholog	1.32514974
59	MP0002066_abnormal_motor_capabilities/c	1.26753414
60	MP0002909_abnormal_adrenal_gland	1.23696591
61	MP0000778_abnormal_nervous_system	1.23205552
62	MP0003632_abnormal_nervous_system	1.22762143
63	MP0005647_abnormal_sex_gland	1.21771836
64	MP0004811_abnormal_neuron_physiology	1.20638161
65	MP0004742_abnormal_vestibular_system	1.18662854
66	MP0001963_abnormal_hearing_physiology	1.17202036
67	MP0004924_abnormal_behavior	1.16527755
68	MP0005386_behavior/neurological_phenoty	1.16527755
69	MP0000955_abnormal_spinal_cord	1.16259019
70	MP0003186_abnormal_redox_activity	1.15939815
71	MP0003634_abnormal_glial_cell	1.15558714
72	MP0002882_abnormal_neuron_morphology	1.13147264
73	MP0001485_abnormal_pinna_reflex	1.09337732
74	MP0002229_neurodegeneration	1.08660779
75	MP0009764_decreased_sensitivity_to	1.07514422
76	MP0009643_abnormal_urine_homeostasis	1.07325761
77	MP0003011_delayed_dark_adaptation	1.04958460
78	MP0003787_abnormal_imprinting	1.04238642
79	MP0000604_amyloidosis	1.03790597
80	MP0009384_cardiac_valve_regurgitation	1.01202885
81	MP0006276_abnormal_autonomic_nervous	1.00454958
82	MP0002254_reproductive_system_inflammat	0.97668697
83	MP0000598_abnormal_liver_morphology	0.96671500
84	MP0009763_increased_sensitivity_to	0.93980266
85	MP0003656_abnormal_erythrocyte_physiolo	0.92894470
86	MP0003329_amyloid_beta_deposits	0.89648371
87	MP0001661_extended_life_span	0.87544644
88	MP0009765_abnormal_xenobiotic_induced	0.82569666
89	MP0004270_analgesia	0.80692589
90	MP0005334_abnormal_fat_pad	0.80544349
91	MP0002152_abnormal_brain_morphology	0.80253569
92	MP0003136_yellow_coat_color	0.79918302
93	MP0009642_abnormal_blood_homeostasis	0.78839459
94	MP0002822_catalepsy	0.76817482
95	MP0003183_abnormal_peptide_metabolism	0.76211555
96	MP0005535_abnormal_body_temperature	0.75858790
97	MP0004130_abnormal_muscle_cell	0.75466018
98	MP0006036_abnormal_mitochondrial_physio	0.74904101
99	MP0002078_abnormal_glucose_homeostasis	0.74839160
100	MP0008469_abnormal_protein_level	0.73545663
101	MP0002876_abnormal_thyroid_physiology	0.70958352
102	MP0005666_abnormal_adipose_tissue	0.70250350
103	MP0004381_abnormal_hair_follicle	0.69197048
104	MP0005636_abnormal_mineral_homeostasis	0.68795007
105	MP0005408_hypopigmentation	0.67459951
106	MP0005253_abnormal_eye_physiology	0.66975511
107	MP0002069_abnormal_eating/drinking_beha	0.65353855
108	MP0002184_abnormal_innervation	0.64195310
109	MP0003075_altered_response_to	0.64047290
110	MP0008874_decreased_physiological_sensi	0.64022640
111	MP0003172_abnormal_lysosome_physiology	0.63949188
112	MP0004885_abnormal_endolymph	0.63553865
113	MP0000026_abnormal_inner_ear	0.63529568
114	MP0002102_abnormal_ear_morphology	0.61764993
115	MP0001853_heart_inflammation	0.60364584
116	MP0005376_homeostasis/metabolism_phenot	0.59966951
117	MP0001502_abnormal_circadian_rhythm	0.58116908
118	MP0002971_abnormal_brown_adipose	0.58064929
119	MP0005084_abnormal_gallbladder_morpholo	0.57913959
120	MP0002089_abnormal_postnatal_growth/wei	0.56228339
121	MP0000639_abnormal_adrenal_gland	0.54511115
122	MP0000579_abnormal_nail_morphology	0.54158598
123	MP0008877_abnormal_DNA_methylation	0.53364414
124	MP0004147_increased_porphyrin_level	0.52185165
125	MP0001529_abnormal_vocalization	0.50586643
126	MP0003953_abnormal_hormone_level	0.50076940
127	MP0005248_abnormal_Harderian_gland	0.50021827
128	MP0008872_abnormal_physiological_respon	0.46428794
129	MP0005266_abnormal_metabolism	0.46182697
130	MP0000566_synostosis	0.45866594
131	MP0010368_abnormal_lymphatic_system	0.45794705
132	MP0002928_abnormal_bile_duct	0.45615815
133	MP0003300_gastrointestinal_ulcer	0.44635922
134	MP0005409_darkened_coat_color	0.44405070
135	MP0005166_decreased_susceptibility_to	0.44147017
136	MP0003633_abnormal_nervous_system	0.43714764
137	MP0005220_abnormal_exocrine_pancreas	0.42471279
138	MP0005395_other_phenotype	0.42423383
139	MP0002168_other_aberrant_phenotype	0.41296198
140	MP0002796_impaired_skin_barrier	0.40148602
141	MP0001756_abnormal_urination	0.38733379
142	MP0005448_abnormal_energy_balance	0.38259343
143	MP0005167_abnormal_blood-brain_barrier	0.37269558
144	MP0004142_abnormal_muscle_tone	0.37200781
145	MP0009672_abnormal_birth_weight	0.36974208
146	MP0008873_increased_physiological_sensi	0.36920313
147	MP0003638_abnormal_response/metabolism_	0.36085068
148	MP0009115_abnormal_fat_cell	0.35722727
149	MP0001881_abnormal_mammary_gland	0.35021746
150	MP0004043_abnormal_pH_regulation	0.34368370
151	MP0002090_abnormal_vision	0.33927386
152	MP0000230_abnormal_systemic_arterial	0.32775183
153	MP0001440_abnormal_grooming_behavior	0.31239805
154	MP0005646_abnormal_pituitary_gland	0.30538583
155	MP0003631_nervous_system_phenotype	0.30261729
156	MP0001177_atelectasis	0.29446210
157	MP0002136_abnormal_kidney_physiology	0.28667076

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intrahepatic cholestasis (HP:0001406)	7.08758582
2	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.03957803
3	Deep venous thrombosis (HP:0002625)	7.02270812
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.44766665
5	Prolonged partial thromboplastin time (HP:0003645)	6.20645707
6	Hyperlipoproteinemia (HP:0010980)	6.05436090
7	Xanthomatosis (HP:0000991)	6.03992278
8	Myokymia (HP:0002411)	5.97420368
9	Hypobetalipoproteinemia (HP:0003563)	5.80109941
10	Focal motor seizures (HP:0011153)	5.41896325
11	Complement deficiency (HP:0004431)	5.30968953
12	Diplopia (HP:0000651)	4.84157311
13	Abnormality of binocular vision (HP:0011514)	4.84157311
14	Focal seizures (HP:0007359)	4.73650633
15	Abnormality of methionine metabolism (HP:0010901)	4.70914723
16	Joint hemorrhage (HP:0005261)	4.56514947
17	Hypolipoproteinemia (HP:0010981)	4.51708511
18	Action tremor (HP:0002345)	4.50487434
19	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.47675923
20	Epidermoid cyst (HP:0200040)	4.43215165
21	Hyperammonemia (HP:0001987)	4.41218221
22	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.40014018
23	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.34197448
24	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.16163059
25	Hypoalphalipoproteinemia (HP:0003233)	4.15891585
26	Ketosis (HP:0001946)	4.13373623
27	Hyperglycinemia (HP:0002154)	4.06176619
28	Epileptic encephalopathy (HP:0200134)	4.02864716
29	Hyperglycinuria (HP:0003108)	3.98315373
30	Neurofibrillary tangles (HP:0002185)	3.98147389
31	Fat malabsorption (HP:0002630)	3.95122462
32	Abnormality of the common coagulation pathway (HP:0010990)	3.92063719
33	Febrile seizures (HP:0002373)	3.88731202
34	Abnormality of glycine metabolism (HP:0010895)	3.84769208
35	Abnormality of serine family amino acid metabolism (HP:0010894)	3.84769208
36	Atonic seizures (HP:0010819)	3.82189776
37	Conjugated hyperbilirubinemia (HP:0002908)	3.79110852
38	Abnormality of complement system (HP:0005339)	3.77887906
39	Generalized tonic-clonic seizures (HP:0002069)	3.69936826
40	Increased circulating renin level (HP:0000848)	3.61666942
41	Abnormality of pyrimidine metabolism (HP:0004353)	3.60525054
42	Ankle clonus (HP:0011448)	3.55150180
43	Hypoglycemic coma (HP:0001325)	3.46786496
44	Alopecia of scalp (HP:0002293)	3.39961790
45	Hypercholesterolemia (HP:0003124)	3.37637463
46	Supranuclear gaze palsy (HP:0000605)	3.36251611
47	Abnormality of the intrinsic pathway (HP:0010989)	3.25360330
48	Abnormal eating behavior (HP:0100738)	3.24375193
49	Vascular calcification (HP:0004934)	3.15801723
50	Hyperbilirubinemia (HP:0002904)	3.14953066
51	Intention tremor (HP:0002080)	3.08541085
52	Postural instability (HP:0002172)	3.07795016
53	Abnormality of serum amino acid levels (HP:0003112)	3.02605740
54	Ketoacidosis (HP:0001993)	3.02474976
55	Myocardial infarction (HP:0001658)	3.01285286
56	Absence seizures (HP:0002121)	3.00834122
57	Steatorrhea (HP:0002570)	2.98433739
58	Hemiplegia (HP:0002301)	2.98175179
59	Cerebral inclusion bodies (HP:0100314)	2.96950137
60	Hemiparesis (HP:0001269)	2.96923455
61	Abnormality of fatty-acid metabolism (HP:0004359)	2.95678381
62	Delayed CNS myelination (HP:0002188)	2.93279711
63	Dysdiadochokinesis (HP:0002075)	2.93028919
64	Abnormality of nucleobase metabolism (HP:0010932)	2.92855958
65	Dialeptic seizures (HP:0011146)	2.87071121
66	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.86876646
67	Torticollis (HP:0000473)	2.86171665
68	Spastic gait (HP:0002064)	2.81458086
69	Cardiovascular calcification (HP:0011915)	2.78817028
70	Dysmetria (HP:0001310)	2.76048090
71	Aplasia involving bones of the extremities (HP:0009825)	2.74690283
72	Aplasia involving bones of the upper limbs (HP:0009823)	2.74690283
73	Aplasia of the phalanges of the hand (HP:0009802)	2.74690283
74	Anxiety (HP:0000739)	2.71290586
75	Peripheral hypomyelination (HP:0007182)	2.69581036
76	Skin nodule (HP:0200036)	2.65770770
77	Hypochromic microcytic anemia (HP:0004840)	2.65012388
78	Hepatocellular carcinoma (HP:0001402)	2.64858348
79	Status epilepticus (HP:0002133)	2.61260400
80	Metabolic acidosis (HP:0001942)	2.60122581
81	Abnormality of purine metabolism (HP:0004352)	2.59021409
82	Dicarboxylic aciduria (HP:0003215)	2.56604054
83	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.56604054
84	Mitral stenosis (HP:0001718)	2.55900430
85	Limb dystonia (HP:0002451)	2.55802565
86	Truncal ataxia (HP:0002078)	2.55658412
87	Progressive cerebellar ataxia (HP:0002073)	2.52626719
88	Spontaneous abortion (HP:0005268)	2.50659059
89	Depression (HP:0000716)	2.49820200
90	Systemic lupus erythematosus (HP:0002725)	2.48844693
91	Scanning speech (HP:0002168)	2.48241448
92	Epileptiform EEG discharges (HP:0011182)	2.47355928
93	Cerebral hypomyelination (HP:0006808)	2.46908645
94	Lethargy (HP:0001254)	2.45517316
95	Focal dystonia (HP:0004373)	2.40953519
96	Gout (HP:0001997)	2.40710336
97	Urinary bladder sphincter dysfunction (HP:0002839)	2.40097897
98	Visual hallucinations (HP:0002367)	2.39255721
99	Bradykinesia (HP:0002067)	2.36747049
100	Impaired vibration sensation in the lower limbs (HP:0002166)	2.36436839
101	Atrioventricular block (HP:0001678)	2.35400167
102	Mutism (HP:0002300)	2.34640138
103	Papilledema (HP:0001085)	2.34500470
104	Megalencephaly (HP:0001355)	2.33742241
105	Acanthocytosis (HP:0001927)	2.32194104
106	Neonatal onset (HP:0003623)	2.31864004
107	Obstructive sleep apnea (HP:0002870)	2.29492305
108	Delusions (HP:0000746)	2.29171519
109	Split foot (HP:0001839)	2.29132643
110	Urinary urgency (HP:0000012)	2.26801706
111	Hypoglycemic seizures (HP:0002173)	2.26512624
112	Spastic diplegia (HP:0001264)	2.26366456
113	Craniofacial dystonia (HP:0012179)	2.25452148
114	Bundle branch block (HP:0011710)	2.25153172
115	Heart block (HP:0012722)	2.24755532
116	Clonus (HP:0002169)	2.24581508
117	Recurrent gram-negative bacterial infections (HP:0005420)	2.23322394
118	Sensorimotor neuropathy (HP:0007141)	2.22433913
119	Cerebral edema (HP:0002181)	2.21982878
120	EEG with generalized epileptiform discharges (HP:0011198)	2.19574220
121	Abnormal gallbladder morphology (HP:0012437)	2.18754551
122	Nephritis (HP:0000123)	2.17737261
123	Abnormality of the corticospinal tract (HP:0002492)	2.17645474
124	Glomerulonephritis (HP:0000099)	2.17502550
125	Retinal atrophy (HP:0001105)	2.17282861
126	Poor eye contact (HP:0000817)	2.16590067
127	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.16505541
128	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.16505541
129	Enlarged kidneys (HP:0000105)	2.15503413
130	Irritability (HP:0000737)	2.15337262
131	Chronic hepatic failure (HP:0100626)	2.15304080
132	Amyloidosis (HP:0011034)	2.14381862
133	Alacrima (HP:0000522)	2.13342553
134	Cholelithiasis (HP:0001081)	2.12664457
135	Hyperventilation (HP:0002883)	2.12328097
136	Rigidity (HP:0002063)	2.12058945
137	Confusion (HP:0001289)	2.08891701
138	Polyphagia (HP:0002591)	2.07269393
139	Amblyopia (HP:0000646)	2.06973609
140	Hypsarrhythmia (HP:0002521)	2.05977254
141	Rickets (HP:0002748)	2.05634244
142	Sleep apnea (HP:0010535)	2.03599982
143	Neuronal loss in central nervous system (HP:0002529)	2.02873310
144	Gingival bleeding (HP:0000225)	2.02638456
145	Abnormality of the periventricular white matter (HP:0002518)	2.00048449
146	Fair hair (HP:0002286)	1.99775092
147	Menorrhagia (HP:0000132)	1.99674464
148	Blue irides (HP:0000635)	1.99537761
149	Lower limb muscle weakness (HP:0007340)	1.98928322
150	Alkalosis (HP:0001948)	1.97894712
151	Morphological abnormality of the pyramidal tract (HP:0002062)	1.97739846
152	Hypophosphatemic rickets (HP:0004912)	1.96447953
153	Pancreatitis (HP:0001733)	1.95887782
154	Esophageal varix (HP:0002040)	1.95372595
155	Akinesia (HP:0002304)	1.95174410
156	Choreoathetosis (HP:0001266)	1.95066135
157	Impaired social interactions (HP:0000735)	1.94300701
158	Abnormal social behavior (HP:0012433)	1.94300701
159	Hypokalemic alkalosis (HP:0001949)	1.93899152
160	Abnormality of cochlea (HP:0000375)	1.93759226
161	Abnormal gallbladder physiology (HP:0012438)	1.93487618
162	Cholecystitis (HP:0001082)	1.93487618
163	Thrombophlebitis (HP:0004418)	1.91637122
164	Late onset (HP:0003584)	1.87215764
165	Cerebral hemorrhage (HP:0001342)	1.86174990
166	Hemorrhage of the eye (HP:0011885)	1.86019104
167	Abnormality of vitamin metabolism (HP:0100508)	1.85758672
168	Hyperinsulinemic hypoglycemia (HP:0000825)	1.83172437
169	Vomiting (HP:0002013)	1.82923354
170	Abnormality of proline metabolism (HP:0010907)	1.81220901
171	Hydroxyprolinuria (HP:0003080)	1.81220901
172	Back pain (HP:0003418)	1.80351239
173	Opisthotonus (HP:0002179)	1.78656714
174	Generalized aminoaciduria (HP:0002909)	1.77097347
175	Malnutrition (HP:0004395)	1.76081900
176	Abnormality of the gallbladder (HP:0005264)	1.75729633
177	Poikilocytosis (HP:0004447)	1.75423420
178	Paraparesis (HP:0002385)	1.74801476
179	Pseudobulbar signs (HP:0002200)	1.74436848
180	Tetraplegia (HP:0002445)	1.74150293

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK2	8.07176868
2	TNIK	7.87920977
3	MKNK1	4.19937345
4	BCKDK	3.75978411
5	MARK1	3.63180662
6	PAK6	3.41812936
7	RIPK1	2.83461616
8	SIK1	2.69698990
9	UHMK1	2.52268845
10	FGFR4	2.47896770
11	CASK	2.39137592
12	INSRR	2.20245524
13	MAP3K9	2.15939768
14	MAP2K4	2.08721538
15	ERN1	1.92669631
16	ERBB4	1.90199171
17	MINK1	1.87201772
18	CAMK2B	1.74748936
19	PLK2	1.70542965
20	TAOK3	1.69410790
21	MAP2K7	1.57138180
22	ARAF	1.56750992
23	MAPK13	1.54572190
24	PRKCG	1.53415815
25	PINK1	1.50074746
26	CDK5	1.42996332
27	KSR2	1.30130764
28	CAMK1	1.25065737
29	DAPK2	1.24320558
30	SGK3	1.18779377
31	PAK3	1.14770114
32	TYRO3	1.13896199
33	EPHA4	1.13589337
34	PKN2	1.06296045
35	MAPK12	1.05639926
36	MAP3K4	1.05269212
37	MST1R	1.01942593
38	PIK3CA	1.01894478
39	DYRK1A	1.00214296
40	FGFR2	0.98999124
41	MAPK11	0.96548084
42	CAMKK2	0.96332310
43	CAMK2D	0.93868461
44	MAP3K7	0.93643905
45	PTK6	0.92560792
46	DAPK1	0.92350633
47	RIPK4	0.91773303
48	FES	0.90459526
49	SGK2	0.87874776
50	MAPK10	0.87233188
51	TRIB3	0.86193497
52	STK11	0.84922404
53	PDK2	0.81634274
54	CDK15	0.80800728
55	MAPK7	0.80520305
56	PIK3CG	0.79270645
57	PRKAA2	0.78000563
58	CDK18	0.76412360
59	TNK2	0.76308415
60	IRAK3	0.75218579
61	ALK	0.74249508
62	JAK2	0.72229938
63	LATS1	0.71949680
64	CDK14	0.71850402
65	MAPK4	0.71626063
66	CDK11A	0.71235662
67	MARK2	0.70745830
68	TYK2	0.69271748
69	CAMK2G	0.69102995
70	BMPR2	0.68263979
71	SIK2	0.68220941
72	MAP3K13	0.68090289
73	MAPKAPK5	0.67688421
74	BRSK1	0.67674027
75	PHKG1	0.67631266
76	PHKG2	0.67631266
77	LATS2	0.67491945
78	SGK494	0.67323704
79	SGK223	0.67323704
80	OXSR1	0.67125552
81	PRPF4B	0.66588741
82	JAK1	0.65290019
83	PRKACG	0.64520038
84	ROCK2	0.63361674
85	MAP3K14	0.62704595
86	FLT3	0.61943020
87	ABL2	0.61295915
88	NTRK2	0.60895530
89	PRKG1	0.59746676
90	ERBB2	0.59116846
91	FRK	0.57538823
92	CDK19	0.53375382
93	CAMKK1	0.52613243
94	PRKCZ	0.51425475
95	STK38	0.51328262
96	PDPK1	0.50635281
97	PRKACB	0.49091633
98	MAP3K1	0.48987870
99	CAMK1D	0.46586071
100	TIE1	0.45610589
101	PRKCH	0.45330416
102	IGF1R	0.44658650
103	BRAF	0.44523950
104	MAP3K2	0.43575348
105	MAP2K1	0.42935075
106	RPS6KB1	0.42773437
107	PRKAA1	0.42584723
108	AKT2	0.40998421
109	CSNK1D	0.40781645
110	PDK1	0.40646593
111	GRK6	0.40550551
112	FYN	0.40444163
113	RET	0.40048186
114	PRKCA	0.39671507
115	PKN1	0.39170308
116	TBK1	0.39022912
117	SGK1	0.38134216
118	PRKD1	0.37591597
119	NEK9	0.37303682
120	BMX	0.36959708
121	NTRK3	0.36958861
122	RAF1	0.35312527
123	TGFBR2	0.34661874
124	ROCK1	0.34594136
125	LMTK2	0.34209556
126	MAP3K11	0.33245876
127	PRKCQ	0.32388507
128	CAMK4	0.30541000
129	CDK6	0.30337206
130	PRKCB	0.30102225
131	MAP2K6	0.28504823
132	CAMK1G	0.28123374
133	RPS6KA3	0.26393843
134	GSK3A	0.25717262
135	CSNK1A1	0.25633253
136	CSNK1E	0.23692315
137	FGFR3	0.23401022
138	NTRK1	0.23049167
139	PRKACA	0.21612937
140	EPHB1	0.20923195
141	CAMK2A	0.20858950
142	CSNK1G2	0.20666685
143	NEK6	0.20010204
144	GRK5	0.19765488
145	PRKD3	0.19320339
146	PRKCE	0.19083590
147	MAPK15	0.17850403
148	MUSK	0.17186127
149	IKBKE	0.15256475
150	KDR	0.14973142
151	CSK	0.13865902

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.47318109
2	Nitrogen metabolism_Homo sapiens_hsa00910	4.29631265
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.41205323
4	Arginine biosynthesis_Homo sapiens_hsa00220	3.20694578
5	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.05170590
6	Tryptophan metabolism_Homo sapiens_hsa00380	2.61205638
7	Complement and coagulation cascades_Homo sapiens_hsa04610	2.59953617
8	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.55461360
9	Fatty acid degradation_Homo sapiens_hsa00071	2.49716369
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.47147458
11	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.40678038
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.31609297
13	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.22260253
14	Butanoate metabolism_Homo sapiens_hsa00650	2.19919033
15	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.00077709
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.99766478
17	Peroxisome_Homo sapiens_hsa04146	1.99409547
18	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.91733036
19	PPAR signaling pathway_Homo sapiens_hsa03320	1.90361219
20	Histidine metabolism_Homo sapiens_hsa00340	1.90289537
21	Propanoate metabolism_Homo sapiens_hsa00640	1.88083865
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.87197476
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.86957501
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.81363390
25	Circadian entrainment_Homo sapiens_hsa04713	1.80659367
26	Chemical carcinogenesis_Homo sapiens_hsa05204	1.80509086
27	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.77276418
28	Bile secretion_Homo sapiens_hsa04976	1.69471724
29	Caffeine metabolism_Homo sapiens_hsa00232	1.68908730
30	Morphine addiction_Homo sapiens_hsa05032	1.68878324
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.68046107
32	Amphetamine addiction_Homo sapiens_hsa05031	1.61624729
33	Long-term potentiation_Homo sapiens_hsa04720	1.59647201
34	Retinol metabolism_Homo sapiens_hsa00830	1.56531900
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.55921973
36	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.55514147
37	Phenylalanine metabolism_Homo sapiens_hsa00360	1.53254576
38	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.52645812
39	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.50991050
40	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.49827856
41	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.44552839
42	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.44098649
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.43983845
44	Tyrosine metabolism_Homo sapiens_hsa00350	1.38971360
45	Gastric acid secretion_Homo sapiens_hsa04971	1.36190284
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.35003517
47	Sulfur metabolism_Homo sapiens_hsa00920	1.28079843
48	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.24214468
49	Fatty acid elongation_Homo sapiens_hsa00062	1.21567074
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.21255766
51	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.21129062
52	Arginine and proline metabolism_Homo sapiens_hsa00330	1.20178166
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.17990738
54	ABC transporters_Homo sapiens_hsa02010	1.17902514
55	Dopaminergic synapse_Homo sapiens_hsa04728	1.16724035
56	Steroid biosynthesis_Homo sapiens_hsa00100	1.15848883
57	Salivary secretion_Homo sapiens_hsa04970	1.15067728
58	Pyruvate metabolism_Homo sapiens_hsa00620	1.10617032
59	Cocaine addiction_Homo sapiens_hsa05030	1.07177128
60	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.06943602
61	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.05668857
62	Folate biosynthesis_Homo sapiens_hsa00790	1.03229189
63	Carbon metabolism_Homo sapiens_hsa01200	1.01101556
64	Lysine degradation_Homo sapiens_hsa00310	1.00074556
65	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.96596687
66	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.95432797
67	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.95139536
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.94062838
69	Renin secretion_Homo sapiens_hsa04924	0.90847019
70	Serotonergic synapse_Homo sapiens_hsa04726	0.89042821
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.89001424
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.88123553
73	cAMP signaling pathway_Homo sapiens_hsa04024	0.84870763
74	Cholinergic synapse_Homo sapiens_hsa04725	0.84396902
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83873501
76	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.82564465
77	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.81932784
78	Taste transduction_Homo sapiens_hsa04742	0.78351597
79	Sulfur relay system_Homo sapiens_hsa04122	0.76813665
80	Calcium signaling pathway_Homo sapiens_hsa04020	0.73793582
81	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.72757078
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70825676
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.69945377
84	Pancreatic secretion_Homo sapiens_hsa04972	0.65457746
85	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.62802996
86	Long-term depression_Homo sapiens_hsa04730	0.62687207
87	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.58396097
88	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.56852805
89	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.56063837
90	Olfactory transduction_Homo sapiens_hsa04740	0.55714205
91	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55201564
92	One carbon pool by folate_Homo sapiens_hsa00670	0.53179315
93	Pentose phosphate pathway_Homo sapiens_hsa00030	0.51855385
94	Glutathione metabolism_Homo sapiens_hsa00480	0.48612276
95	Cardiac muscle contraction_Homo sapiens_hsa04260	0.47865921
96	Estrogen signaling pathway_Homo sapiens_hsa04915	0.43687121
97	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.43353292
98	Collecting duct acid secretion_Homo sapiens_hsa04966	0.43026458
99	Prion diseases_Homo sapiens_hsa05020	0.41573143
100	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.41080030
101	GnRH signaling pathway_Homo sapiens_hsa04912	0.41014676
102	* Metabolic pathways_Homo sapiens_hsa01100	0.40658486
103	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.37255092
104	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.32967217
105	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.30881705
106	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.23004023
107	Insulin resistance_Homo sapiens_hsa04931	0.22090124
108	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.20987457
109	* Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.20797720
110	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.19655210
111	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.17865195
112	Glucagon signaling pathway_Homo sapiens_hsa04922	0.15542671
113	Linoleic acid metabolism_Homo sapiens_hsa00591	0.13524049
114	Galactose metabolism_Homo sapiens_hsa00052	0.13257387
115	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.12426941
116	Circadian rhythm_Homo sapiens_hsa04710	0.10215991
117	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.08821753
118	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.05472305
119	GABAergic synapse_Homo sapiens_hsa04727	0.04713337
120	Regulation of autophagy_Homo sapiens_hsa04140	0.01681962
121	Insulin signaling pathway_Homo sapiens_hsa04910	0.01387813
122	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	-0.1955928
123	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	-0.1945280
124	Mineral absorption_Homo sapiens_hsa04978	-0.1900207
125	mTOR signaling pathway_Homo sapiens_hsa04150	-0.1898839
126	Type II diabetes mellitus_Homo sapiens_hsa04930	-0.1701536
127	Insulin secretion_Homo sapiens_hsa04911	-0.1688516
128	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	-0.1683587
129	Glutamatergic synapse_Homo sapiens_hsa04724	-0.1577504
130	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.1521210
131	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	-0.1149480
132	Nicotine addiction_Homo sapiens_hsa05033	-0.1137506
133	African trypanosomiasis_Homo sapiens_hsa05143	-0.0934918
134	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0740809
135	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	-0.0680863
136	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.0610484
137	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.0602037

ETNPPL

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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