ETS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.92974203
2negative T cell selection (GO:0043383)7.76235427
3negative thymic T cell selection (GO:0045060)7.21073877
4positive T cell selection (GO:0043368)6.99935378
5positive thymic T cell selection (GO:0045059)6.95326349
6regulation of gamma-delta T cell differentiation (GO:0045586)6.90608716
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.60143210
8negative regulation of cell killing (GO:0031342)6.60143210
9T cell selection (GO:0045058)6.44599004
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.32016383
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.32016383
12thymic T cell selection (GO:0045061)6.30552370
13regulation of gamma-delta T cell activation (GO:0046643)6.25764436
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.21419372
15interferon-gamma production (GO:0032609)5.84632291
16response to interleukin-15 (GO:0070672)5.81627932
17antigen processing and presentation of endogenous antigen (GO:0019883)5.75689861
18positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.64982896
19regulation of isotype switching to IgG isotypes (GO:0048302)5.48902953
20regulation of T cell tolerance induction (GO:0002664)5.41491376
21cellular response to interleukin-15 (GO:0071350)5.38659646
22T cell receptor signaling pathway (GO:0050852)5.06657008
23regulation of B cell receptor signaling pathway (GO:0050855)4.86154110
24T cell costimulation (GO:0031295)4.78028929
25tolerance induction (GO:0002507)4.77033005
26lymphocyte costimulation (GO:0031294)4.70228260
27T cell migration (GO:0072678)4.65261636
28leukocyte aggregation (GO:0070486)4.56968059
29antigen receptor-mediated signaling pathway (GO:0050851)4.56145704
30positive regulation of tolerance induction (GO:0002645)4.42690101
31activated T cell proliferation (GO:0050798)4.37367099
32positive regulation of interleukin-2 production (GO:0032743)4.21076349
33regulation of interleukin-2 biosynthetic process (GO:0045076)4.12655107
34regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.12086165
35regulation of alpha-beta T cell proliferation (GO:0046640)4.05455332
36regulation of interleukin-12 biosynthetic process (GO:0045075)4.04252465
37B cell receptor signaling pathway (GO:0050853)3.94054668
38regulation of regulatory T cell differentiation (GO:0045589)3.89203597
39V(D)J recombination (GO:0033151)3.86749969
40regulation of tolerance induction (GO:0002643)3.86662451
41regulation of T cell receptor signaling pathway (GO:0050856)3.81334941
42regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.67020019
43positive regulation of isotype switching (GO:0045830)3.63923027
44alpha-beta T cell activation (GO:0046631)3.60606648
45T cell differentiation (GO:0030217)3.59980146
46regulation of B cell differentiation (GO:0045577)3.59522068
47alpha-beta T cell differentiation (GO:0046632)3.55756964
48modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.55459085
49positive regulation by organism of defense response of other organism involved in symbiotic interact3.55459085
50modulation by symbiont of host immune response (GO:0052553)3.55459085
51positive regulation by symbiont of host defense response (GO:0052509)3.55459085
52modulation by symbiont of host defense response (GO:0052031)3.55459085
53modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.55459085
54positive regulation of alpha-beta T cell proliferation (GO:0046641)3.54285748
55negative regulation of leukocyte mediated immunity (GO:0002704)3.47524417
56negative regulation of T cell mediated immunity (GO:0002710)3.43310858
57negative regulation of erythrocyte differentiation (GO:0045647)3.42951375
58antigen processing and presentation via MHC class Ib (GO:0002475)3.42447874
59regulation of response to interferon-gamma (GO:0060330)3.41400902
60regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.39443366
61regulation of isotype switching (GO:0045191)3.38720414
62cellular extravasation (GO:0045123)3.38202981
63detection of other organism (GO:0098543)3.37605736
64detection of bacterium (GO:0016045)3.35668359
65T cell homeostasis (GO:0043029)3.34106804
66endothelial tube morphogenesis (GO:0061154)3.32839293
67morphogenesis of an endothelium (GO:0003159)3.32839293
68leukocyte cell-cell adhesion (GO:0007159)3.32643202
69immune response-activating cell surface receptor signaling pathway (GO:0002429)3.31387333
70regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.26632504
71regulation of natural killer cell mediated immunity (GO:0002715)3.26632504
72regulation of T cell mediated cytotoxicity (GO:0001914)3.26418184
73response to type I interferon (GO:0034340)3.26015036
74cellular response to type I interferon (GO:0071357)3.25410866
75type I interferon signaling pathway (GO:0060337)3.25410866
76lymphocyte homeostasis (GO:0002260)3.19362444
77regulation of interleukin-2 production (GO:0032663)3.17481854
78B cell proliferation (GO:0042100)3.14086185
79positive regulation of natural killer cell mediated immunity (GO:0002717)3.12417015
80positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.12417015
81response to muramyl dipeptide (GO:0032495)3.09783833
82T cell activation (GO:0042110)3.07845647
83histone H3-K36 demethylation (GO:0070544)3.07371348
84positive regulation of DNA recombination (GO:0045911)3.07120619
85negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.06828686
86positive regulation of T cell mediated cytotoxicity (GO:0001916)3.05006047
87B cell homeostasis (GO:0001782)3.03719702
88JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.03664053
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.03527338
90mast cell activation (GO:0045576)3.02870805
91negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.02788099
92mucosal-associated lymphoid tissue development (GO:0048537)3.02032117
93Peyers patch development (GO:0048541)3.02032117
94positive regulation of B cell differentiation (GO:0045579)3.00521950
95positive regulation of immunoglobulin production (GO:0002639)2.99685483
96macrophage activation involved in immune response (GO:0002281)2.99429343
97negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.98688718
98regulation of granulocyte differentiation (GO:0030852)2.98491855
99natural killer cell activation (GO:0030101)2.97632516
100heterotypic cell-cell adhesion (GO:0034113)2.97480276
101positive regulation of humoral immune response (GO:0002922)2.97202876
102T cell proliferation (GO:0042098)2.95808451
103germinal center formation (GO:0002467)2.94351312
104negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.94319175
105negative regulation of T-helper cell differentiation (GO:0045623)2.94319175
106regulation of defense response to virus by virus (GO:0050690)2.93315063
107negative regulation of T cell receptor signaling pathway (GO:0050860)2.92438504
108negative regulation of thymocyte apoptotic process (GO:0070244)2.92202480
109regulation of immunoglobulin production (GO:0002637)2.90882126
110regulation of type I interferon-mediated signaling pathway (GO:0060338)2.89792201
111NIK/NF-kappaB signaling (GO:0038061)2.89478980
112regulation of alpha-beta T cell activation (GO:0046634)2.89473930
113negative regulation of interleukin-12 production (GO:0032695)2.89079761
114positive regulation of granulocyte differentiation (GO:0030854)2.86579889
115positive regulation of T cell activation (GO:0050870)2.85500746
116positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.85216667
117natural killer cell differentiation (GO:0001779)2.82055133
118positive regulation of B cell mediated immunity (GO:0002714)2.80968530
119positive regulation of immunoglobulin mediated immune response (GO:0002891)2.80968530
120phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.80956177
121negative regulation of phagocytosis (GO:0050765)2.80741072
122hepatocyte apoptotic process (GO:0097284)2.80203746
123regulation of necroptotic process (GO:0060544)2.79043949
124positive regulation of histone deacetylation (GO:0031065)2.78994871
125regulation of immunoglobulin mediated immune response (GO:0002889)2.78486084
126CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.77080347
127regulation of interferon-beta biosynthetic process (GO:0045357)2.76517796
128positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.74724865
129positive regulation of alpha-beta T cell activation (GO:0046635)2.74023730
130lymph node development (GO:0048535)2.73549520
131negative regulation of lymphocyte mediated immunity (GO:0002707)2.73501819
132regulation of B cell mediated immunity (GO:0002712)2.72826754
133lymphocyte differentiation (GO:0030098)2.72781388
134T-helper cell differentiation (GO:0042093)2.72163753
135CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.72163753
136regulation of B cell proliferation (GO:0030888)2.71523123
137positive regulation of B cell proliferation (GO:0030890)2.70884102
138establishment of endothelial barrier (GO:0061028)2.70857887
139regulation of leukocyte mediated cytotoxicity (GO:0001910)2.70556494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.08111234
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.41257918
3RUNX_20019798_ChIP-Seq_JUKART_Human4.08898367
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.96694518
5* MYC_22102868_ChIP-Seq_BL_Human3.80935979
6* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.73790167
7* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.62237883
8* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.27924184
9E2F7_22180533_ChIP-Seq_HELA_Human3.27220532
10* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.22266244
11* MYB_26560356_Chip-Seq_TH2_Human3.19386309
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.17684588
13* MAF_26560356_Chip-Seq_TH1_Human2.94163964
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91666035
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.87996775
16* UTX_26944678_Chip-Seq_JUKART_Human2.73610050
17* MYB_26560356_Chip-Seq_TH1_Human2.73136965
18* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61560478
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51473254
20VDR_21846776_ChIP-Seq_THP-1_Human2.39691456
21TCF7_22412390_ChIP-Seq_EML_Mouse2.25616500
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.24284006
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.06100647
24* GATA3_27048872_Chip-Seq_THYMUS_Human2.05840410
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.03827363
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99875495
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99872456
28KDM2B_26808549_Chip-Seq_DND41_Human1.94791482
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90791663
30* MAF_26560356_Chip-Seq_TH2_Human1.89378097
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.86750329
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84656960
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.83510719
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81185191
35* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80743286
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79808406
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78514442
38VDR_24763502_ChIP-Seq_THP-1_Human1.74715551
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.74120294
40* SCL_19346495_ChIP-Seq_HPC-7_Human1.70111766
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68107670
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.67222161
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64486828
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64139423
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.63441400
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61779485
47SPI1_23547873_ChIP-Seq_NB4_Human1.61022194
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.55283891
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.53099346
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46136326
51SPI1_23127762_ChIP-Seq_K562_Human1.44295091
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43413546
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42967410
54* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.42885686
55CIITA_25753668_ChIP-Seq_RAJI_Human1.42305337
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.36597981
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33537045
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25573276
59PU_27001747_Chip-Seq_BMDM_Mouse1.24053900
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22120928
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18677275
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15996134
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15952175
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11715551
65* GATA3_26560356_Chip-Seq_TH2_Human1.10865474
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08913737
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03608770
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03202922
69NCOR1_26117541_ChIP-Seq_K562_Human1.02474539
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.01137115
71ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99716548
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99215889
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96657073
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96612898
75GATA2_21666600_ChIP-Seq_HMVEC_Human0.96036658
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95155633
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94602172
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92017164
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91217317
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91047106
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89118006
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88938976
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88885662
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88845781
85GATA1_19941826_ChIP-Seq_K562_Human0.88197889
86CLOCK_20551151_ChIP-Seq_293T_Human0.87095823
87* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86881608
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85432964
89GATA1_22025678_ChIP-Seq_K562_Human0.84128515
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83883469
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83139161
92GATA2_19941826_ChIP-Seq_K562_Human0.82780687
93* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80238957
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78734380
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77240924
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75079225
97* VDR_24787735_ChIP-Seq_THP-1_Human0.75056856
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74899885
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74139267
100LXR_22292898_ChIP-Seq_THP-1_Human0.74054086
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.73092015
102E2F4_17652178_ChIP-ChIP_JURKAT_Human0.72644544
103HIF1A_21447827_ChIP-Seq_MCF-7_Human0.71793287
104CTCF_27219007_Chip-Seq_ERYTHROID_Human0.70867594
105* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.69899575
106ELK1_19687146_ChIP-ChIP_HELA_Human0.68438430
107ERG_20887958_ChIP-Seq_HPC-7_Mouse0.68222115
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.68051803
109SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.65201394
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.64756741
111* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63362762
112CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63266949
113FOXP3_21729870_ChIP-Seq_TREG_Human0.62965769
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.62898927
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.62455837
116HOXB4_20404135_ChIP-ChIP_EML_Mouse0.60961288
117* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.60737686

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003763_abnormal_thymus_physiology4.82417889
2MP0005671_abnormal_response_to3.86502645
3MP0000685_abnormal_immune_system3.37688115
4MP0001800_abnormal_humoral_immune3.26523417
5MP0001835_abnormal_antigen_presentation3.08006378
6MP0002166_altered_tumor_susceptibility3.06662734
7MP0005387_immune_system_phenotype3.05600201
8MP0001790_abnormal_immune_system3.05600201
9MP0003300_gastrointestinal_ulcer2.80593712
10* MP0002398_abnormal_bone_marrow2.70679808
11* MP0002420_abnormal_adaptive_immunity2.66154509
12* MP0001819_abnormal_immune_cell2.60734912
13* MP0000703_abnormal_thymus_morphology2.58351016
14MP0005000_abnormal_immune_tolerance2.57763093
15MP0002723_abnormal_immune_serum2.56658563
16MP0001873_stomach_inflammation2.55535952
17* MP0002452_abnormal_antigen_presenting2.52779681
18* MP0000716_abnormal_immune_system2.33629663
19MP0002006_tumorigenesis2.33190450
20MP0002396_abnormal_hematopoietic_system2.24469578
21MP0003303_peritoneal_inflammation2.20794923
22MP0002405_respiratory_system_inflammati2.20465716
23* MP0002722_abnormal_immune_system2.19356875
24* MP0000689_abnormal_spleen_morphology2.16190638
25MP0002933_joint_inflammation2.15754966
26MP0010155_abnormal_intestine_physiology2.12151816
27MP0003724_increased_susceptibility_to2.07630504
28MP0009785_altered_susceptibility_to2.05934982
29MP0004947_skin_inflammation2.03498896
30MP0004808_abnormal_hematopoietic_stem1.94466194
31* MP0002429_abnormal_blood_cell1.92930439
32* MP0009333_abnormal_splenocyte_physiolog1.91852689
33MP0005025_abnormal_response_to1.91573543
34MP0003436_decreased_susceptibility_to1.85626876
35MP0006082_CNS_inflammation1.77601508
36MP0003866_abnormal_defecation1.75489255
37MP0001879_abnormal_lymphatic_vessel1.66142160
38MP0002419_abnormal_innate_immunity1.57454453
39MP0009278_abnormal_bone_marrow1.57444694
40MP0005451_abnormal_body_composition1.52348629
41MP0001845_abnormal_inflammatory_respons1.52213592
42MP0008260_abnormal_autophagy1.51296588
43MP0002148_abnormal_hypersensitivity_rea1.48949343
44MP0010352_gastrointestinal_tract_polyps1.48728077
45MP0000465_gastrointestinal_hemorrhage1.48439919
46MP0006054_spinal_hemorrhage1.43711438
47MP0005464_abnormal_platelet_physiology1.42578997
48MP0001853_heart_inflammation1.37629983
49MP0010368_abnormal_lymphatic_system1.37150231
50MP0005397_hematopoietic_system_phenotyp1.31211333
51MP0001545_abnormal_hematopoietic_system1.31211333
52MP0004510_myositis1.26834537
53MP0000858_altered_metastatic_potential1.24025669
54MP0004883_abnormal_blood_vessel1.19895114
55MP0002009_preneoplasia1.17836171
56MP0005023_abnormal_wound_healing1.17547166
57MP0003828_pulmonary_edema1.17415103
58MP0003091_abnormal_cell_migration1.16322205
59MP0003448_altered_tumor_morphology1.13089757
60MP0004381_abnormal_hair_follicle1.09712713
61MP0003191_abnormal_cellular_cholesterol1.09531280
62MP0003279_aneurysm1.05388773
63MP0008961_abnormal_basal_metabolism1.04524836
64MP0001533_abnormal_skeleton_physiology1.04453376
65MP0003045_fibrosis1.04111894
66MP0005076_abnormal_cell_differentiation1.00677622
67MP0003172_abnormal_lysosome_physiology0.99138608
68MP0001851_eye_inflammation0.98892149
69MP0001348_abnormal_lacrimal_gland0.98807943
70MP0002019_abnormal_tumor_incidence0.97563786
71MP0002132_abnormal_respiratory_system0.97438620
72MP0004130_abnormal_muscle_cell0.97328190
73MP0003566_abnormal_cell_adhesion0.95446481
74MP0002998_abnormal_bone_remodeling0.93951648
75MP0000490_abnormal_crypts_of0.93261067
76MP0002138_abnormal_hepatobiliary_system0.88951782
77MP0005164_abnormal_response_to0.86480622
78MP0008469_abnormal_protein_level0.84203143
79MP0003221_abnormal_cardiomyocyte_apopto0.79291446
80MP0000767_abnormal_smooth_muscle0.76133874
81MP0008057_abnormal_DNA_replication0.74225456
82MP0000733_abnormal_muscle_development0.72494751
83MP0003077_abnormal_cell_cycle0.71936638
84MP0003690_abnormal_glial_cell0.71925961
85MP0003453_abnormal_keratinocyte_physiol0.70817100
86MP0003943_abnormal_hepatobiliary_system0.70588444
87MP0003787_abnormal_imprinting0.69012878
88MP0005310_abnormal_salivary_gland0.68160110
89MP0008007_abnormal_cellular_replicative0.67483355
90MP0001243_abnormal_dermal_layer0.67461245
91MP0005166_decreased_susceptibility_to0.67152793
92MP0009764_decreased_sensitivity_to0.66632261
93* MP0000249_abnormal_blood_vessel0.66411833
94MP0005075_abnormal_melanosome_morpholog0.65984300
95MP0002136_abnormal_kidney_physiology0.64676539
96MP0003795_abnormal_bone_structure0.64314866
97MP0005621_abnormal_cell_physiology0.64311586
98MP0010234_abnormal_vibrissa_follicle0.63965391
99MP0003183_abnormal_peptide_metabolism0.63147207
100MP0010094_abnormal_chromosome_stability0.60387102
101MP0005390_skeleton_phenotype0.60082152
102MP0003705_abnormal_hypodermis_morpholog0.59967382
103MP0001958_emphysema0.59670756
104MP0002086_abnormal_extraembryonic_tissu0.59148510
105* MP0002925_abnormal_cardiovascular_devel0.58580791
106MP0001191_abnormal_skin_condition0.58374073
107MP0000569_abnormal_digit_pigmentation0.57610711
108MP0002332_abnormal_exercise_endurance0.56501377
109MP0009115_abnormal_fat_cell0.56378857
110MP0002277_abnormal_respiratory_mucosa0.55440165
111MP0000477_abnormal_intestine_morphology0.54661897
112MP0009763_increased_sensitivity_to0.54556742
113MP0010630_abnormal_cardiac_muscle0.54114097
114MP0000609_abnormal_liver_physiology0.53743805
115* MP0002128_abnormal_blood_circulation0.53655404
116* MP0001784_abnormal_fluid_regulation0.53461724
117MP0001663_abnormal_digestive_system0.52755191
118MP0004185_abnormal_adipocyte_glucose0.50072750
119MP0000015_abnormal_ear_pigmentation0.49111675
120MP0001915_intracranial_hemorrhage0.48712533
121MP0002877_abnormal_melanocyte_morpholog0.48222413

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.11490533
2Abnormality of T cell number (HP:0011839)6.77635068
3Severe combined immunodeficiency (HP:0004430)4.76285087
4Panhypogammaglobulinemia (HP:0003139)4.73955590
5Recurrent viral infections (HP:0004429)4.71048200
6Abnormality of T cells (HP:0002843)4.68640611
7Recurrent bronchitis (HP:0002837)4.60683058
8Combined immunodeficiency (HP:0005387)4.46557561
9B lymphocytopenia (HP:0010976)4.44247936
10Abnormality of B cell number (HP:0010975)4.44247936
11Thyroiditis (HP:0100646)4.14074547
12Recurrent fungal infections (HP:0002841)4.07411331
13Recurrent bacterial skin infections (HP:0005406)4.06717757
14Abnormality of the fingertips (HP:0001211)4.00050635
15IgM deficiency (HP:0002850)3.92164668
16Eosinophilia (HP:0001880)3.83037883
17IgG deficiency (HP:0004315)3.74879147
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.69075168
19Agammaglobulinemia (HP:0004432)3.67183557
20Chronic otitis media (HP:0000389)3.66473506
21Elevated erythrocyte sedimentation rate (HP:0003565)3.56586344
22Abnormality of eosinophils (HP:0001879)3.48611333
23Verrucae (HP:0200043)3.37009574
24Papilloma (HP:0012740)3.37009574
25Nasal polyposis (HP:0100582)3.31185306
26Spontaneous hematomas (HP:0007420)3.28452676
27Recurrent cutaneous fungal infections (HP:0011370)3.27523064
28Chronic mucocutaneous candidiasis (HP:0002728)3.27523064
29Abnormality of macrophages (HP:0004311)3.25884259
30Abnormality of the nasal mucosa (HP:0000433)3.24358118
31Lymphopenia (HP:0001888)3.23961412
32Granulocytopenia (HP:0001913)3.21014784
33Stomatitis (HP:0010280)3.20161078
34Meningitis (HP:0001287)3.09849920
35Abnormality of cells of the lymphoid lineage (HP:0012140)3.08950746
36Pustule (HP:0200039)3.06926776
37Myositis (HP:0100614)3.06824017
38Inflammation of the large intestine (HP:0002037)3.01851076
39Chronic diarrhea (HP:0002028)3.00874050
40Hypoplasia of the thymus (HP:0000778)2.97992574
41Gastrointestinal inflammation (HP:0004386)2.96488452
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.86321988
43Leukocytosis (HP:0001974)2.86185803
44Autoimmune thrombocytopenia (HP:0001973)2.77812044
45Papilledema (HP:0001085)2.74380557
46IgA deficiency (HP:0002720)2.72714311
47Colitis (HP:0002583)2.72556623
48Abnormality of T cell physiology (HP:0011840)2.71623265
49Recurrent sinusitis (HP:0011108)2.70991683
50Autoimmune hemolytic anemia (HP:0001890)2.64008702
51Eczematoid dermatitis (HP:0000976)2.60782866
52Vasculitis (HP:0002633)2.59113981
53Gingivitis (HP:0000230)2.57354440
54Slow saccadic eye movements (HP:0000514)2.56137002
55Recurrent gram-negative bacterial infections (HP:0005420)2.54260228
56Obstructive lung disease (HP:0006536)2.54156690
57Chronic obstructive pulmonary disease (HP:0006510)2.54156690
58Increased IgM level (HP:0003496)2.53591233
59Aortic aneurysm (HP:0004942)2.50228856
60Joint swelling (HP:0001386)2.48162502
61Bronchitis (HP:0012387)2.47936803
62Chronic sinusitis (HP:0011109)2.46444494
63Abnormal platelet volume (HP:0011876)2.43709377
64Abnormal foot bone ossification (HP:0010675)2.41986903
65Gastrointestinal stroma tumor (HP:0100723)2.41217900
66Hemoptysis (HP:0002105)2.39236154
67Encephalitis (HP:0002383)2.39059255
68Basal cell carcinoma (HP:0002671)2.36867721
69Lymphoma (HP:0002665)2.35807608
70Cellulitis (HP:0100658)2.34250955
71Retrobulbar optic neuritis (HP:0100654)2.30410400
72Optic neuritis (HP:0100653)2.30410400
73Emphysema (HP:0002097)2.29446301
74Pulmonary infiltrates (HP:0002113)2.27033527
75Increased density of long bones (HP:0006392)2.25378484
76Osteomyelitis (HP:0002754)2.23906637
77Recurrent otitis media (HP:0000403)2.21258592
78Bicuspid aortic valve (HP:0001647)2.17733024
79Hematochezia (HP:0002573)2.15965704
80Increased IgE level (HP:0003212)2.15384326
81Arterial thrombosis (HP:0004420)2.15060482
82Persistence of primary teeth (HP:0006335)2.13653864
83Gingival bleeding (HP:0000225)2.13298973
84Orchitis (HP:0100796)2.10929615
85Urticaria (HP:0001025)2.09623684
86Pulmonary embolism (HP:0002204)2.08303019
87Hypergammaglobulinemia (HP:0010702)2.07682503
88Sepsis (HP:0100806)2.06962713
89Increased mean platelet volume (HP:0011877)2.06749177
90Fatigue (HP:0012378)2.00092682
91Mediastinal lymphadenopathy (HP:0100721)1.98364801
92Ureteral stenosis (HP:0000071)1.97943969
93Prolonged bleeding time (HP:0003010)1.97879125
94Subacute progressive viral hepatitis (HP:0006572)1.97751521
95Keratoconjunctivitis sicca (HP:0001097)1.96685395
96Hemiplegia (HP:0002301)1.95594573
97Hypoproteinemia (HP:0003075)1.94063865
98Small epiphyses (HP:0010585)1.91303548
99Cerebral aneurysm (HP:0004944)1.90906363
100Hypochromic anemia (HP:0001931)1.90374675
101Teleangiectasia of the skin (HP:0100585)1.89267848
102Glomerulopathy (HP:0100820)1.87982613
103Chest pain (HP:0100749)1.87497556
104Anorexia (HP:0002039)1.87348956
105Abnormality of the pleura (HP:0002103)1.86046373
106Recurrent skin infections (HP:0001581)1.85461919
107Epistaxis (HP:0000421)1.84930915
108Ureteral obstruction (HP:0006000)1.84493008
109Hepatitis (HP:0012115)1.83691679
110Vertebral arch anomaly (HP:0008438)1.81687201
111Viral hepatitis (HP:0006562)1.81492114
112Thrombocytosis (HP:0001894)1.79932907
113Dislocated radial head (HP:0003083)1.78461774
114Glucose intolerance (HP:0000833)1.77024448
115Abnormality of the peritoneum (HP:0002585)1.76477963
116Skin ulcer (HP:0200042)1.75684752
117Restrictive lung disease (HP:0002091)1.75614756
118Microcytic anemia (HP:0001935)1.73410829
119Limited elbow extension (HP:0001377)1.72812797
120Keratoconjunctivitis (HP:0001096)1.72803104
121Cutis marmorata (HP:0000965)1.72524218
122Recurrent abscess formation (HP:0002722)1.72485292
123Aortic dissection (HP:0002647)1.71957530
124Gastrointestinal infarctions (HP:0005244)1.71800397
125Acute hepatic failure (HP:0006554)1.71795564
126Gangrene (HP:0100758)1.71628856
127Short 4th metacarpal (HP:0010044)1.71303194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.45554861
2TXK5.08331418
3PRPF4B3.85201695
4ITK3.25737338
5STK103.09905627
6RIPK42.97363219
7FGFR42.95529229
8JAK32.75489341
9GRK62.65183722
10ZAP702.39819366
11FGFR32.35572654
12TYK22.30670930
13MAP3K102.25908829
14NLK2.08440602
15KDR2.08330116
16JAK12.02927151
17IKBKE1.90638194
18MAP3K141.80061426
19TEC1.75193127
20TGFBR21.75121675
21TIE11.74084604
22CSK1.67947026
23LCK1.64446965
24PKN21.64384274
25MARK31.61052104
26PASK1.58858652
27EEF2K1.58541971
28TAOK31.51725650
29MST41.51299298
30LRRK21.47981027
31HCK1.40895783
32SYK1.36689642
33BTK1.36102461
34CAMKK21.30757895
35TTN1.29835101
36CDK121.29562611
37PRKCH1.28922460
38PRKCQ1.27401813
39CLK11.17777748
40FGFR21.16210473
41SMG11.15082516
42TBK11.13466745
43MAP3K131.12753638
44CAMKK11.08742536
45PIM11.08663812
46TRIB31.07393658
47EPHB11.03221135
48SIK21.00374975
49PDGFRB0.96490739
50FGR0.92472945
51MAP3K70.89703778
52EPHA30.88852176
53MAP3K10.88656926
54YES10.85073897
55CDC42BPA0.84781625
56IKBKB0.84415122
57MAP2K30.83065937
58PTK60.82781894
59JAK20.81427610
60TGFBR10.80552370
61RPS6KA40.79196446
62MELK0.76232214
63CSF1R0.74076185
64SIK30.72746101
65STK40.72708013
66CHUK0.72279546
67IRAK10.70676599
68KSR20.68736393
69CDK40.68290905
70KIT0.67761596
71LYN0.67677102
72BLK0.67463749
73STK380.65188448
74DMPK0.65092327
75BMPR20.64207766
76IRAK40.62981213
77TAOK10.61069371
78TYRO30.60365846
79PRKD20.59386443
80FES0.58867020
81STK240.58645860
82NUAK10.58619865
83PIK3CG0.58149181
84CDK90.58001405
85TRPM70.57533347
86INSR0.57107313
87MAP3K30.56545368
88RIPK10.54613612
89CDK60.54387646
90MARK20.53099300
91SGK30.51707036
92ERN10.51245295
93BRD40.51244985
94SGK20.49530927
95HIPK20.48210055
96PDK10.46966564
97PTK2B0.46859354
98FLT30.46796094
99WNK10.46514335
100ICK0.46514045
101MAP3K110.43858887
102SIK10.41856896
103PDPK10.41216333
104TSSK60.40876144
105TNK20.40052580
106TAOK20.39131187
107ALK0.38915515
108NME20.36567573
109PDGFRA0.35996209
110IRAK20.35797765
111FGFR10.35208517
112FYN0.34484348
113RPS6KL10.33470433
114RPS6KC10.33470433
115MAPK110.31838475
116PRKD10.30777392
117MAP3K80.30673305
118NEK20.30374718
119RPS6KB20.30054746
120EGFR0.28580660
121RET0.26348659
122NEK90.26202570
123IRAK30.25795899
124TESK20.25549546
125ABL10.25115952
126* IGF1R0.24318088
127CAMK1D0.20926595
128* MAPK30.20413212

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.65782191
2T cell receptor signaling pathway_Homo sapiens_hsa046603.61538551
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.72854989
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.59101598
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.51807303
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.48654931
7Measles_Homo sapiens_hsa051622.47479181
8B cell receptor signaling pathway_Homo sapiens_hsa046622.43231082
9Antigen processing and presentation_Homo sapiens_hsa046122.27412425
10Hematopoietic cell lineage_Homo sapiens_hsa046402.22446352
11Osteoclast differentiation_Homo sapiens_hsa043801.98660328
12Viral myocarditis_Homo sapiens_hsa054161.97125835
13Allograft rejection_Homo sapiens_hsa053301.89711488
14Graft-versus-host disease_Homo sapiens_hsa053321.77946302
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.77574156
16Leishmaniasis_Homo sapiens_hsa051401.75210152
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.60973978
18Autoimmune thyroid disease_Homo sapiens_hsa053201.51402780
19Toxoplasmosis_Homo sapiens_hsa051451.46241174
20Herpes simplex infection_Homo sapiens_hsa051681.43168092
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41148114
22Acute myeloid leukemia_Homo sapiens_hsa052211.39685951
23Hepatitis B_Homo sapiens_hsa051611.35129806
24Chemokine signaling pathway_Homo sapiens_hsa040621.33340281
25Chronic myeloid leukemia_Homo sapiens_hsa052201.31251542
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30916263
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25345076
28Platelet activation_Homo sapiens_hsa046111.24958139
29Pancreatic cancer_Homo sapiens_hsa052121.21029086
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18806403
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18614733
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18498859
33* HTLV-I infection_Homo sapiens_hsa051661.17403923
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13136934
35Shigellosis_Homo sapiens_hsa051311.12529338
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11778217
37TNF signaling pathway_Homo sapiens_hsa046681.10189195
38Influenza A_Homo sapiens_hsa051641.09374067
39Colorectal cancer_Homo sapiens_hsa052101.09214971
40Non-homologous end-joining_Homo sapiens_hsa034501.07502243
41Small cell lung cancer_Homo sapiens_hsa052221.03501254
42Apoptosis_Homo sapiens_hsa042100.99813085
43Adherens junction_Homo sapiens_hsa045200.98366342
44Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95186015
45Viral carcinogenesis_Homo sapiens_hsa052030.94637605
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93895702
47Epstein-Barr virus infection_Homo sapiens_hsa051690.93612481
48Malaria_Homo sapiens_hsa051440.91476803
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89112932
50FoxO signaling pathway_Homo sapiens_hsa040680.86733194
51Hepatitis C_Homo sapiens_hsa051600.85038190
52Non-small cell lung cancer_Homo sapiens_hsa052230.84900478
53VEGF signaling pathway_Homo sapiens_hsa043700.83256793
54Notch signaling pathway_Homo sapiens_hsa043300.82377455
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81684753
56Prostate cancer_Homo sapiens_hsa052150.80506487
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79296631
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.79001073
59Prolactin signaling pathway_Homo sapiens_hsa049170.78670859
60Focal adhesion_Homo sapiens_hsa045100.78037793
61ErbB signaling pathway_Homo sapiens_hsa040120.71264838
62MicroRNAs in cancer_Homo sapiens_hsa052060.71046284
63Endometrial cancer_Homo sapiens_hsa052130.70425328
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69625852
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69608804
66Glioma_Homo sapiens_hsa052140.69297901
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68805047
68Proteoglycans in cancer_Homo sapiens_hsa052050.67500097
69Rap1 signaling pathway_Homo sapiens_hsa040150.67383870
70Thyroid cancer_Homo sapiens_hsa052160.66741180
71African trypanosomiasis_Homo sapiens_hsa051430.66523743
72Insulin resistance_Homo sapiens_hsa049310.63886944
73Tuberculosis_Homo sapiens_hsa051520.61834167
74GnRH signaling pathway_Homo sapiens_hsa049120.61571927
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60802099
76Lysine degradation_Homo sapiens_hsa003100.60699829
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60519508
78Other glycan degradation_Homo sapiens_hsa005110.60342367
79mTOR signaling pathway_Homo sapiens_hsa041500.59059647
80Legionellosis_Homo sapiens_hsa051340.58385548
81Staphylococcus aureus infection_Homo sapiens_hsa051500.57614000
82HIF-1 signaling pathway_Homo sapiens_hsa040660.57333940
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56581958
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56504107
85p53 signaling pathway_Homo sapiens_hsa041150.56276364
86Endocytosis_Homo sapiens_hsa041440.56164217
87MAPK signaling pathway_Homo sapiens_hsa040100.55664560
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55377993
89Salmonella infection_Homo sapiens_hsa051320.53388876
90Rheumatoid arthritis_Homo sapiens_hsa053230.51188303
91* Pathways in cancer_Homo sapiens_hsa052000.49774447
92Long-term potentiation_Homo sapiens_hsa047200.49223767
93* Ras signaling pathway_Homo sapiens_hsa040140.48731325
94Inositol phosphate metabolism_Homo sapiens_hsa005620.47569910
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47432084
96Phagosome_Homo sapiens_hsa041450.47290866
97Pertussis_Homo sapiens_hsa051330.44954981
98Amoebiasis_Homo sapiens_hsa051460.44802056
99Type I diabetes mellitus_Homo sapiens_hsa049400.44212171
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43584536
101Choline metabolism in cancer_Homo sapiens_hsa052310.42121096
102Asthma_Homo sapiens_hsa053100.42079964
103* Renal cell carcinoma_Homo sapiens_hsa052110.39774865
104Spliceosome_Homo sapiens_hsa030400.39599738
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38131313
106mRNA surveillance pathway_Homo sapiens_hsa030150.37192509
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.36907932
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.36173551
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35364630
110ECM-receptor interaction_Homo sapiens_hsa045120.34574172
111Base excision repair_Homo sapiens_hsa034100.33544738
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29698650
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27972448
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.27839191

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