ETS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.45948466
2desmosome organization (GO:0002934)4.89664160
3negative regulation of erythrocyte differentiation (GO:0045647)4.39193067
4bundle of His cell to Purkinje myocyte communication (GO:0086069)4.33151100
5response to peptidoglycan (GO:0032494)4.21243518
6regulation of vitamin metabolic process (GO:0030656)3.69740031
7vascular endothelial growth factor signaling pathway (GO:0038084)3.60703456
8regulation of vitamin D biosynthetic process (GO:0060556)3.43150693
9wound healing, spreading of epidermal cells (GO:0035313)3.38147783
10positive regulation of p38MAPK cascade (GO:1900745)3.33263166
11cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.30022990
12regulation of p38MAPK cascade (GO:1900744)3.28401241
13germinal center formation (GO:0002467)3.22183341
14cell-substrate junction assembly (GO:0007044)3.19938537
15low-density lipoprotein particle clearance (GO:0034383)3.17264437
16lipopolysaccharide-mediated signaling pathway (GO:0031663)3.17158928
17plasma membrane repair (GO:0001778)3.15326744
18cell adhesion mediated by integrin (GO:0033627)3.04375986
19protein localization to endosome (GO:0036010)3.02149467
20positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.00250439
21positive regulation of gamma-delta T cell activation (GO:0046645)2.99426121
22response to muramyl dipeptide (GO:0032495)2.99329411
23immunoglobulin mediated immune response (GO:0016064)2.96459399
24negative regulation of interleukin-12 production (GO:0032695)2.96036446
25regulation of necrotic cell death (GO:0010939)2.94232065
26detection of other organism (GO:0098543)2.93867680
27regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93547965
28lymph vessel development (GO:0001945)2.90348753
29mature B cell differentiation involved in immune response (GO:0002313)2.87936083
30positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.87901712
31angiotensin maturation (GO:0002003)2.87785785
32cell migration involved in sprouting angiogenesis (GO:0002042)2.87319146
33surfactant homeostasis (GO:0043129)2.86096542
34establishment of endothelial barrier (GO:0061028)2.81811057
35regulation of T-helper 2 cell differentiation (GO:0045628)2.81315999
36regulation of cardioblast differentiation (GO:0051890)2.81058506
37cytoskeletal anchoring at plasma membrane (GO:0007016)2.78340508
38detection of bacterium (GO:0016045)2.77867401
39neutrophil activation involved in immune response (GO:0002283)2.76990408
40apoptotic cell clearance (GO:0043277)2.76210413
41pinocytosis (GO:0006907)2.75087856
42regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.74839179
43regulation of membrane protein ectodomain proteolysis (GO:0051043)2.74752655
44blood vessel endothelial cell migration (GO:0043534)2.73276623
45embryonic process involved in female pregnancy (GO:0060136)2.72902789
46T-helper 1 type immune response (GO:0042088)2.72585007
47regulation of cellular extravasation (GO:0002691)2.70192378
48mannose metabolic process (GO:0006013)2.69206210
49atrioventricular valve morphogenesis (GO:0003181)2.69007500
50lymphangiogenesis (GO:0001946)2.68955038
51morphogenesis of an endothelium (GO:0003159)2.67483721
52endothelial tube morphogenesis (GO:0061154)2.67483721
53cellular response to thyroid hormone stimulus (GO:0097067)2.66457398
54growth hormone receptor signaling pathway (GO:0060396)2.65688050
55regulation of leukocyte degranulation (GO:0043300)2.65110545
56antigen processing and presentation of endogenous antigen (GO:0019883)2.61707504
57retina vasculature morphogenesis in camera-type eye (GO:0061299)2.61688154
58regulation of myeloid leukocyte mediated immunity (GO:0002886)2.59099170
59regulation of necroptotic process (GO:0060544)2.58162591
60regulation of mast cell degranulation (GO:0043304)2.57879090
61wound healing, spreading of cells (GO:0044319)2.57413509
62regulation of podosome assembly (GO:0071801)2.57319586
63peptide catabolic process (GO:0043171)2.56844934
64negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.56789964
65negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.55278008
66cyclooxygenase pathway (GO:0019371)2.54770857
67endothelial cell morphogenesis (GO:0001886)2.53223474
68dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.53117841
69vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.52572268
70positive regulation of fatty acid biosynthetic process (GO:0045723)2.52357759
71regulation of T-helper 1 cell differentiation (GO:0045625)2.51977181
72glycosphingolipid catabolic process (GO:0046479)2.51812114
73definitive hemopoiesis (GO:0060216)2.50437171
74regulation of cholesterol storage (GO:0010885)2.50007039
75complement activation, classical pathway (GO:0006958)2.49949164
76response to protozoan (GO:0001562)2.48448081
77detection of external biotic stimulus (GO:0098581)2.48182583
78basement membrane organization (GO:0071711)2.47777097
79regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.47427913
80negative regulation of granulocyte differentiation (GO:0030853)2.47334536
81modulation by symbiont of host defense response (GO:0052031)2.47125903
82modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.47125903
83modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.47125903
84positive regulation by organism of defense response of other organism involved in symbiotic interact2.47125903
85modulation by symbiont of host immune response (GO:0052553)2.47125903
86positive regulation by symbiont of host defense response (GO:0052509)2.47125903
87regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46542570
88negative regulation of cell fate specification (GO:0009996)2.46071901
89response to laminar fluid shear stress (GO:0034616)2.45505814
90skin morphogenesis (GO:0043589)2.44864886
91complement activation, alternative pathway (GO:0006957)2.44170648
92complement activation (GO:0006956)2.43719706
93epithelial cell-cell adhesion (GO:0090136)2.42352183
94axon extension involved in axon guidance (GO:0048846)2.40583360
95neuron projection extension involved in neuron projection guidance (GO:1902284)2.40583360
96fibroblast migration (GO:0010761)2.40230712
97patterning of blood vessels (GO:0001569)2.39651265
98positive regulation of Cdc42 GTPase activity (GO:0043089)2.38570994
99NIK/NF-kappaB signaling (GO:0038061)2.37687410
100interferon-gamma-mediated signaling pathway (GO:0060333)2.36742298
101regulation of gamma-delta T cell activation (GO:0046643)2.36031450
102ventricular cardiac muscle cell action potential (GO:0086005)2.35564438
103regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.35486748
104detection of molecule of bacterial origin (GO:0032490)2.35233476
105endothelial cell chemotaxis (GO:0035767)2.35214556
106substrate-dependent cell migration (GO:0006929)2.34847569
107cellular extravasation (GO:0045123)2.34400885
108negative regulation of interleukin-8 production (GO:0032717)2.33321785
109glycolipid catabolic process (GO:0019377)2.33146179
110semaphorin-plexin signaling pathway (GO:0071526)2.32108175
111defense response to protozoan (GO:0042832)2.31990191
112regulation of cholesterol homeostasis (GO:2000188)2.31824278
113positive regulation of type 2 immune response (GO:0002830)2.31701017
114chemical homeostasis within a tissue (GO:0048875)2.31305938
115detection of biotic stimulus (GO:0009595)2.30352571
116regulation of mast cell activation involved in immune response (GO:0033006)2.28654247
117endodermal cell differentiation (GO:0035987)2.28560104
118regulation of chemokine biosynthetic process (GO:0045073)2.28545756
119regulation of antigen processing and presentation (GO:0002577)2.27863187
120positive regulation of leukocyte degranulation (GO:0043302)2.27702869
121regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.27033558
122interferon-gamma secretion (GO:0072643)2.26423364
123positive regulation of endothelial cell apoptotic process (GO:2000353)2.26370002
124positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.26330496
125regulation of water loss via skin (GO:0033561)2.25190209
126macrophage activation (GO:0042116)2.25160153
127regulation of transforming growth factor beta2 production (GO:0032909)2.24416125
128negative regulation of cytokine production involved in immune response (GO:0002719)2.24367531
129acute-phase response (GO:0006953)2.23953766
130cellular response to growth hormone stimulus (GO:0071378)2.23795983
131oligosaccharide catabolic process (GO:0009313)2.23530541
132regulation of heterotypic cell-cell adhesion (GO:0034114)2.22974860
133glomerular filtration (GO:0003094)2.22653111
134mesodermal cell differentiation (GO:0048333)2.21742961
135stress fiber assembly (GO:0043149)2.21379600
136positive regulation of macrophage cytokine production (GO:0060907)2.20555457
137negative regulation of vascular permeability (GO:0043116)2.20488412
138response to thyroid hormone (GO:0097066)2.19985660
139positive regulation of B cell differentiation (GO:0045579)2.19136062
140regulation of complement activation (GO:0030449)2.18219405
141regulation of type 2 immune response (GO:0002828)2.18026772
142regulation of macrophage chemotaxis (GO:0010758)2.18025635
143regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.16134093
144positive regulation of antigen processing and presentation (GO:0002579)2.15795702
145macrophage activation involved in immune response (GO:0002281)2.15685831
146positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.15179172
147response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.13902764
148response to host (GO:0075136)2.13902764
149response to host defenses (GO:0052200)2.13902764
150regulation of vasculogenesis (GO:2001212)2.13859722
151sarcomere organization (GO:0045214)2.13750539
152positive regulation of chemokine biosynthetic process (GO:0045080)2.13657266
153platelet-derived growth factor receptor signaling pathway (GO:0048008)2.12442380
154positive regulation of vasculogenesis (GO:2001214)2.12204703
155renal filtration (GO:0097205)2.12173811
156regulation of protein activation cascade (GO:2000257)2.12167841
157blood vessel maturation (GO:0001955)2.11858422
158negative regulation of toll-like receptor signaling pathway (GO:0034122)2.11856545
159positive regulation of phagocytosis (GO:0050766)2.11443714
160adherens junction assembly (GO:0034333)2.10491055
161cell communication involved in cardiac conduction (GO:0086065)2.10366767
162epithelial cell differentiation involved in prostate gland development (GO:0060742)2.10079119
163JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.09361595
164regulation of endothelial cell differentiation (GO:0045601)2.09098971
165endothelium development (GO:0003158)2.07139898
166coronary vasculature morphogenesis (GO:0060977)2.06747527
167heart trabecula formation (GO:0060347)2.05910174
168intestinal epithelial cell development (GO:0060576)2.05867306
169negative regulation of fatty acid transport (GO:2000192)2.04813834
170regulation of tight junction assembly (GO:2000810)2.04187768
171positive regulation of histone deacetylation (GO:0031065)2.03676299
172negative regulation of cardiac muscle tissue growth (GO:0055022)2.02009034
173negative regulation of heart growth (GO:0061117)2.02009034
174antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.01082600
175antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.01082600
176branching involved in salivary gland morphogenesis (GO:0060445)2.00848542
177cardiac myofibril assembly (GO:0055003)1.99631926
178regulation of integrin activation (GO:0033623)1.99143293
179lung vasculature development (GO:0060426)1.98754672
180lung lobe morphogenesis (GO:0060463)1.98643473

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.69367540
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.38874014
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.86023606
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.69491285
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.55802143
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44597291
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.39629258
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.38781037
9CLOCK_20551151_ChIP-Seq_293T_Human2.36209300
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.30439298
11VDR_21846776_ChIP-Seq_THP-1_Human2.15153086
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.11329104
13* VDR_24763502_ChIP-Seq_THP-1_Human2.10723148
14* SCL_19346495_ChIP-Seq_HPC-7_Human1.99456874
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98687026
16GATA2_21666600_ChIP-Seq_HMVEC_Human1.94885878
17* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92836348
18* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86162768
19* FOXO3_23340844_ChIP-Seq_DLD1_Human1.85681065
20IRF8_21731497_ChIP-ChIP_J774_Mouse1.81652050
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.79738401
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79347156
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79266362
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.78176526
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76440863
26* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72888464
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.72734009
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71361013
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70772039
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.62565170
31* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.60066821
32* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.60066821
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59406911
34* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58262604
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55821356
36ZNF263_19887448_ChIP-Seq_K562_Human1.54305071
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51622540
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51406592
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.51176793
40RACK7_27058665_Chip-Seq_MCF-7_Human1.51145445
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48629707
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47199473
43* SOX2_20726797_ChIP-Seq_SW620_Human1.45302863
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.43670664
45TCF7_22412390_ChIP-Seq_EML_Mouse1.43533571
46* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41549117
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.40899349
48* LXR_22158963_ChIP-Seq_LIVER_Mouse1.39586207
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38422309
50* RUNX1_27514584_Chip-Seq_MCF-7_Human1.37788889
51TBX20_22080862_ChIP-Seq_HEART_Mouse1.36506234
52TBX20_22328084_ChIP-Seq_HEART_Mouse1.36506234
53MYC_22102868_ChIP-Seq_BL_Human1.35720162
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35408383
55KDM2B_26808549_Chip-Seq_DND41_Human1.35398857
56ATF3_27146783_Chip-Seq_COLON_Human1.34216874
57* CJUN_26792858_Chip-Seq_BT549_Human1.33990313
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32909259
59* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31295900
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29672388
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29331938
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.29068002
63KDM2B_26808549_Chip-Seq_K562_Human1.28499024
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28172514
65ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.28160811
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27449350
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27231135
68* EP300_21415370_ChIP-Seq_HL-1_Mouse1.27068666
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26744670
70LXR_22292898_ChIP-Seq_THP-1_Human1.26343464
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24835592
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24241810
73* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23734248
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.23139863
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22071924
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20894482
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19101398
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18853697
79* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18522019
80RXR_22158963_ChIP-Seq_LIVER_Mouse1.17889996
81GATA6_25053715_ChIP-Seq_YYC3_Human1.17571921
82GATA1_19941826_ChIP-Seq_K562_Human1.16471358
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.15880761
84* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14849743
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14057536
86GATA1_22025678_ChIP-Seq_K562_Human1.13173307
87* KLF5_25053715_ChIP-Seq_YYC3_Human1.13061611
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12985382
89MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10899571
90* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10350483
91* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09195402
92RUNX_20019798_ChIP-Seq_JUKART_Human1.09006205
93* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08125453
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07857652
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07459765
96UBF1/2_26484160_Chip-Seq_HMECs_Human1.06589279
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06482761
98GATA4_25053715_ChIP-Seq_YYC3_Human1.05651913
99IRF8_27001747_Chip-Seq_BMDM_Mouse1.05542693
100AHR_22903824_ChIP-Seq_MCF-7_Human1.04019241
101UTX_26944678_Chip-Seq_JUKART_Human1.03684248
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03446337
103RXR_22108803_ChIP-Seq_LS180_Human1.03397542
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03234651
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02006591
106BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01508335
107KDM2B_26808549_Chip-Seq_JURKAT_Human1.00847311
108* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00556245
109VDR_24787735_ChIP-Seq_THP-1_Human1.00534148
110CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00332360
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99348176
112* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99245449
113* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98622410
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97956652
115GATA2_19941826_ChIP-Seq_K562_Human0.97659271
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97273585
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96387704
118* SPI1_23547873_ChIP-Seq_NB4_Human0.96358446
119* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95634184
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95572205
121* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94899848
122* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94856760
123IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94834194
124SPI1_23127762_ChIP-Seq_K562_Human0.93940507
125MYB_26560356_Chip-Seq_TH2_Human0.93689302
126MAF_26560356_Chip-Seq_TH1_Human0.93469772
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93410063

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.98304074
2MP0003705_abnormal_hypodermis_morpholog3.60373845
3MP0010368_abnormal_lymphatic_system3.08556339
4MP0005167_abnormal_blood-brain_barrier2.81008368
5MP0004272_abnormal_basement_membrane2.67838225
6MP0002254_reproductive_system_inflammat2.63483509
7MP0003300_gastrointestinal_ulcer2.59831433
8MP0001879_abnormal_lymphatic_vessel2.52549989
9MP0002139_abnormal_hepatobiliary_system2.47502292
10MP0003566_abnormal_cell_adhesion2.40549505
11MP0003303_peritoneal_inflammation2.38602159
12MP0003828_pulmonary_edema2.24814943
13MP0002796_impaired_skin_barrier2.22368176
14MP0003724_increased_susceptibility_to2.21532555
15MP0002148_abnormal_hypersensitivity_rea2.18660649
16MP0010352_gastrointestinal_tract_polyps2.11022242
17MP0005275_abnormal_skin_tensile2.10427834
18MP0006054_spinal_hemorrhage2.09853039
19MP0001835_abnormal_antigen_presentation2.08084554
20MP0004947_skin_inflammation2.06124740
21MP0009278_abnormal_bone_marrow2.02739310
22MP0003453_abnormal_keratinocyte_physiol2.02338482
23MP0004510_myositis1.98017496
24MP0005025_abnormal_response_to1.95135933
25MP0005058_abnormal_lysosome_morphology1.94332013
26MP0005451_abnormal_body_composition1.92433097
27MP0005464_abnormal_platelet_physiology1.86152395
28MP0005076_abnormal_cell_differentiation1.83932274
29MP0005360_urolithiasis1.83040363
30MP0000465_gastrointestinal_hemorrhage1.79921385
31MP0005397_hematopoietic_system_phenotyp1.79459502
32MP0001545_abnormal_hematopoietic_system1.79459502
33MP0005000_abnormal_immune_tolerance1.78881191
34MP0005387_immune_system_phenotype1.69811308
35MP0001790_abnormal_immune_system1.69811308
36MP0004264_abnormal_extraembryonic_tissu1.69288844
37MP0006082_CNS_inflammation1.65339525
38MP0002060_abnormal_skin_morphology1.65072467
39MP0002877_abnormal_melanocyte_morpholog1.62618457
40MP0004084_abnormal_cardiac_muscle1.61099432
41MP0005023_abnormal_wound_healing1.54059773
42MP0001849_ear_inflammation1.52862359
43MP0002452_abnormal_antigen_presenting1.47035441
44MP0005409_darkened_coat_color1.46675809
45MP0001800_abnormal_humoral_immune1.45359001
46MP0002396_abnormal_hematopoietic_system1.45260479
47MP0003191_abnormal_cellular_cholesterol1.44189838
48MP0001216_abnormal_epidermal_layer1.44017527
49MP0002723_abnormal_immune_serum1.42878867
50MP0002138_abnormal_hepatobiliary_system1.40612257
51MP0001853_heart_inflammation1.38595190
52* MP0010678_abnormal_skin_adnexa1.36911107
53MP0000604_amyloidosis1.33100137
54MP0003436_decreased_susceptibility_to1.33004728
55MP0001845_abnormal_inflammatory_respons1.31468333
56MP0000750_abnormal_muscle_regeneration1.30331024
57MP0008961_abnormal_basal_metabolism1.29289242
58MP0001819_abnormal_immune_cell1.27289377
59MP0000767_abnormal_smooth_muscle1.26754711
60MP0002420_abnormal_adaptive_immunity1.26671129
61MP0003045_fibrosis1.25891576
62MP0003656_abnormal_erythrocyte_physiolo1.25033974
63MP0008469_abnormal_protein_level1.24362489
64MP0003091_abnormal_cell_migration1.22188188
65MP0000685_abnormal_immune_system1.22043021
66MP0004808_abnormal_hematopoietic_stem1.21549326
67MP0000343_altered_response_to1.21014576
68MP0000858_altered_metastatic_potential1.20604907
69MP0002166_altered_tumor_susceptibility1.18956067
70MP0005165_increased_susceptibility_to1.18467937
71MP0003866_abnormal_defecation1.17268887
72MP0003172_abnormal_lysosome_physiology1.17243736
73MP0002405_respiratory_system_inflammati1.17117660
74MP0010630_abnormal_cardiac_muscle1.16643389
75MP0010155_abnormal_intestine_physiology1.14183580
76MP0004130_abnormal_muscle_cell1.13769867
77MP0008004_abnormal_stomach_pH1.11955342
78MP0009333_abnormal_splenocyte_physiolog1.11844087
79MP0005501_abnormal_skin_physiology1.10216790
80MP0000013_abnormal_adipose_tissue1.10146813
81* MP0000383_abnormal_hair_follicle1.09550923
82MP0004484_altered_response_of1.09344323
83MP0001851_eye_inflammation1.09318721
84MP0001544_abnormal_cardiovascular_syste1.09305112
85MP0005385_cardiovascular_system_phenoty1.09305112
86MP0003075_altered_response_to1.09145533
87MP0003183_abnormal_peptide_metabolism1.08433524
88MP0002972_abnormal_cardiac_muscle1.08325324
89MP0005666_abnormal_adipose_tissue1.06863875
90MP0001533_abnormal_skeleton_physiology1.06837505
91MP0005330_cardiomyopathy1.06342884
92MP0008438_abnormal_cutaneous_collagen1.05769700
93MP0000537_abnormal_urethra_morphology1.05045135
94MP0004185_abnormal_adipocyte_glucose1.04731622
95MP0009785_altered_susceptibility_to1.04143853
96MP0001958_emphysema1.03871181
97MP0006138_congestive_heart_failure1.03502196
98MP0003329_amyloid_beta_deposits1.02961658
99MP0000751_myopathy1.02954121
100MP0004087_abnormal_muscle_fiber1.02801261
101MP0000678_abnormal_parathyroid_gland1.02725221
102MP0002006_tumorigenesis1.00263381
103MP0002998_abnormal_bone_remodeling0.99055178
104MP0005365_abnormal_bile_salt0.98526484
105MP0002896_abnormal_bone_mineralization0.97796010
106MP0004215_abnormal_myocardial_fiber0.95517804
107MP0005187_abnormal_penis_morphology0.95222156
108MP0000249_abnormal_blood_vessel0.94824064
109* MP0002098_abnormal_vibrissa_morphology0.94752580
110MP0001666_abnormal_nutrient_absorption0.94195129
111MP0002837_dystrophic_cardiac_calcinosis0.93511407
112MP0000716_abnormal_immune_system0.92842307
113MP0001191_abnormal_skin_condition0.91542753
114MP0003279_aneurysm0.90710255
115MP0000733_abnormal_muscle_development0.90168339
116MP0003763_abnormal_thymus_physiology0.89979626
117MP0004782_abnormal_surfactant_physiolog0.89355846
118MP0005390_skeleton_phenotype0.89057228
119MP0003806_abnormal_nucleotide_metabolis0.88929608
120MP0009931_abnormal_skin_appearance0.86967519
121MP0009763_increased_sensitivity_to0.86540057
122MP0000003_abnormal_adipose_tissue0.86200158
123MP0008775_abnormal_heart_ventricle0.85797986
124* MP0010771_integument_phenotype0.84436342
125MP0002398_abnormal_bone_marrow0.83292216
126* MP0002925_abnormal_cardiovascular_devel0.83027321
127MP0005164_abnormal_response_to0.82451072
128MP0004036_abnormal_muscle_relaxation0.82365143
129MP0005166_decreased_susceptibility_to0.81642655
130MP0009780_abnormal_chondrocyte_physiolo0.81596029
131MP0005085_abnormal_gallbladder_physiolo0.81275389
132MP0000377_abnormal_hair_follicle0.81100267
133MP0002234_abnormal_pharynx_morphology0.80936522
134MP0005375_adipose_tissue_phenotype0.80934538
135MP0001243_abnormal_dermal_layer0.80618930
136MP0003690_abnormal_glial_cell0.80358445
137MP0009840_abnormal_foam_cell0.80180707
138MP0003941_abnormal_skin_development0.80088413
139MP0002295_abnormal_pulmonary_circulatio0.79507320
140MP0000579_abnormal_nail_morphology0.79429089
141MP0002332_abnormal_exercise_endurance0.79161992
142MP0005671_abnormal_response_to0.78088010
143MP0009643_abnormal_urine_homeostasis0.76968283
144MP0009765_abnormal_xenobiotic_induced0.76778994
145MP0002128_abnormal_blood_circulation0.75762063
146MP0009764_decreased_sensitivity_to0.74501227
147MP0002419_abnormal_innate_immunity0.73575145
148MP0009053_abnormal_anal_canal0.71738662
149MP0000467_abnormal_esophagus_morphology0.70912344
150* MP0003448_altered_tumor_morphology0.70254956

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.30880886
2Systemic lupus erythematosus (HP:0002725)4.65142868
3Milia (HP:0001056)4.32293745
4Atrophic scars (HP:0001075)3.92485432
5Hematochezia (HP:0002573)3.66961869
6Complement deficiency (HP:0004431)3.63915787
7Increased connective tissue (HP:0009025)3.46569274
8Abnormality of complement system (HP:0005339)3.46487360
9Ventricular tachycardia (HP:0004756)3.44579274
10Cerebral aneurysm (HP:0004944)3.31826041
11Malnutrition (HP:0004395)3.19921051
12Glomerulonephritis (HP:0000099)3.15045109
13Onycholysis (HP:0001806)3.09163097
14Plantar hyperkeratosis (HP:0007556)3.07462324
15Esophageal varix (HP:0002040)3.07400268
16Amyloidosis (HP:0011034)3.05721091
17Myositis (HP:0100614)3.04710839
18Orchitis (HP:0100796)2.96571699
19Fragile nails (HP:0001808)2.90337856
20Sudden death (HP:0001699)2.86739409
21Polycythemia (HP:0001901)2.85164641
22Thick nail (HP:0001805)2.83688916
23Abnormality of macrophages (HP:0004311)2.82703994
24Hyporeflexia of lower limbs (HP:0002600)2.81268290
25Deep venous thrombosis (HP:0002625)2.78852418
26Rectal prolapse (HP:0002035)2.76788660
27Abnormality of glycolipid metabolism (HP:0010969)2.73195205
28Abnormality of liposaccharide metabolism (HP:0010968)2.73195205
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.73195205
30Increased cerebral lipofuscin (HP:0011813)2.67067251
31Abnormality of monocarboxylic acid metabolism (HP:0010996)2.61931003
32Interstitial pulmonary disease (HP:0006530)2.61010187
33Cellulitis (HP:0100658)2.59488200
34Recurrent abscess formation (HP:0002722)2.57841073
35Recurrent bacterial skin infections (HP:0005406)2.57283660
36Recurrent gram-negative bacterial infections (HP:0005420)2.56843121
37Woolly hair (HP:0002224)2.51538877
38Polygenic inheritance (HP:0010982)2.51500076
39Gingival bleeding (HP:0000225)2.49808713
40Alopecia of scalp (HP:0002293)2.48553953
41Prolonged bleeding time (HP:0003010)2.44594363
42Epistaxis (HP:0000421)2.42611892
43Purpura (HP:0000979)2.40590037
44Eczematoid dermatitis (HP:0000976)2.39473297
45Retrobulbar optic neuritis (HP:0100654)2.39390307
46Optic neuritis (HP:0100653)2.39390307
47Spontaneous hematomas (HP:0007420)2.38380549
48Aortic aneurysm (HP:0004942)2.37347135
49Gingivitis (HP:0000230)2.37114580
50Aneurysm (HP:0002617)2.35978936
51Fragile skin (HP:0001030)2.35846604
52Ventricular fibrillation (HP:0001663)2.32761190
53Muscle fiber splitting (HP:0003555)2.32509395
54Increased neuronal autofluorescent lipopigment (HP:0002074)2.31783933
55Neurofibrillary tangles (HP:0002185)2.27664076
56Mildly elevated creatine phosphokinase (HP:0008180)2.27623558
57Arterial tortuosity (HP:0005116)2.26707078
58Segmental peripheral demyelination/remyelination (HP:0003481)2.26532892
59Hypotrichosis (HP:0001006)2.26345930
60Colitis (HP:0002583)2.26258546
61Dysostosis multiplex (HP:0000943)2.24718234
62Mitral valve prolapse (HP:0001634)2.23519568
63Mediastinal lymphadenopathy (HP:0100721)2.22844151
64Broad metatarsal (HP:0001783)2.21935105
65Syncope (HP:0001279)2.19866674
66Protrusio acetabuli (HP:0003179)2.19480534
67Pili torti (HP:0003777)2.19055198
68Subacute progressive viral hepatitis (HP:0006572)2.18943182
69Keratoconjunctivitis sicca (HP:0001097)2.18648358
70Palmoplantar hyperkeratosis (HP:0000972)2.17556566
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.16829384
72Difficulty climbing stairs (HP:0003551)2.15732422
73Myocardial infarction (HP:0001658)2.15035065
74Autoimmune thrombocytopenia (HP:0001973)2.13961113
75Increased serum ferritin (HP:0003281)2.12594166
76Abnormality of the gastric mucosa (HP:0004295)2.11867180
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10173843
78Stomatitis (HP:0010280)2.10014720
79Vasculitis (HP:0002633)2.03924421
80Loss of speech (HP:0002371)2.02764488
81Micronodular cirrhosis (HP:0001413)2.02419450
82Vascular tortuosity (HP:0004948)2.01278218
83Pustule (HP:0200039)2.00458237
84Peritonitis (HP:0002586)2.00387746
85Increased variability in muscle fiber diameter (HP:0003557)1.99728584
86Exercise-induced muscle cramps (HP:0003710)1.99570221
87Difficulty running (HP:0009046)1.99178814
88Gangrene (HP:0100758)1.99071199
89Lymphangioma (HP:0100764)1.97827672
90Petechiae (HP:0000967)1.97779669
91Recurrent viral infections (HP:0004429)1.97717355
92Abnormality of iron homeostasis (HP:0011031)1.97481636
93Palmar hyperkeratosis (HP:0010765)1.96238360
94Inflammation of the large intestine (HP:0002037)1.95100295
95Nail dystrophy (HP:0008404)1.93647468
96Aortic dissection (HP:0002647)1.93473406
97Flat acetabular roof (HP:0003180)1.92720418
98Shallow orbits (HP:0000586)1.92148310
99Hypoplasia of dental enamel (HP:0006297)1.91103274
100Gastrointestinal inflammation (HP:0004386)1.90259148
101Recurrent skin infections (HP:0001581)1.89080216
102Ventricular arrhythmia (HP:0004308)1.89020792
103Xerostomia (HP:0000217)1.88498509
104Axonal loss (HP:0003447)1.88417328
105Asymmetric septal hypertrophy (HP:0001670)1.88086786
106Autoimmune hemolytic anemia (HP:0001890)1.87996822
107Mucopolysacchariduria (HP:0008155)1.86961453
108Urinary glycosaminoglycan excretion (HP:0003541)1.86961453
109Recurrent fungal infections (HP:0002841)1.86802893
110Urticaria (HP:0001025)1.85755998
111Arterial thrombosis (HP:0004420)1.85396146
112Abnormality of polysaccharide metabolism (HP:0011012)1.85072640
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85072640
114Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85072640
115Osteolytic defects of the hand bones (HP:0009699)1.84574117
116Osteolytic defects of the phalanges of the hand (HP:0009771)1.84574117
117Ankyloglossia (HP:0010296)1.83768251
118Long toe (HP:0010511)1.83528654
119Keratoconjunctivitis (HP:0001096)1.82900814
120Meningitis (HP:0001287)1.82781362
121Atrial fibrillation (HP:0005110)1.81543502
122Type 1 muscle fiber predominance (HP:0003803)1.81517355
123Abnormality of skeletal muscle fiber size (HP:0012084)1.81178195
124Neonatal death (HP:0003811)1.80851803
125Striae distensae (HP:0001065)1.80752378
126Hypergammaglobulinemia (HP:0010702)1.79496596
127Distal lower limb muscle weakness (HP:0009053)1.77534060
128Thrombocytosis (HP:0001894)1.77478714
129Spinal rigidity (HP:0003306)1.77341055
130Impaired platelet aggregation (HP:0003540)1.76592721
131Abnormal platelet function (HP:0011869)1.76592721
132Stroke (HP:0001297)1.76426460
133Obstructive lung disease (HP:0006536)1.76050276
134Chronic obstructive pulmonary disease (HP:0006510)1.76050276
135Dilatation of the ascending aorta (HP:0005111)1.75875912
136Tetraparesis (HP:0002273)1.74616052
137Pulmonary infiltrates (HP:0002113)1.74516109
138Thin bony cortex (HP:0002753)1.73015956
139Curly hair (HP:0002212)1.72839822
140Nephritis (HP:0000123)1.72685049
141Cerebral inclusion bodies (HP:0100314)1.72213760
142Acanthosis nigricans (HP:0000956)1.71492722
143Primary atrial arrhythmia (HP:0001692)1.70968094
144Supraventricular arrhythmia (HP:0005115)1.70528428
145Scapular winging (HP:0003691)1.70448232
146Episodic fever (HP:0001954)1.68752766
147Lipoatrophy (HP:0100578)1.68501241
148Cervical subluxation (HP:0003308)1.68454009
149Abnormality of the nasal mucosa (HP:0000433)1.67685352
150Centrally nucleated skeletal muscle fibers (HP:0003687)1.67418185
151Visceral angiomatosis (HP:0100761)1.67360129
152Hemoptysis (HP:0002105)1.66560517
153Premature rupture of membranes (HP:0001788)1.66099350
154Thrombophlebitis (HP:0004418)1.65987533
155Erythema (HP:0010783)1.65548008
156Pulmonary embolism (HP:0002204)1.65261341
157Joint swelling (HP:0001386)1.65255588
158Chest pain (HP:0100749)1.64221191
159Periodontitis (HP:0000704)1.64153600
160Hemorrhage of the eye (HP:0011885)1.63632342
161EMG: myopathic abnormalities (HP:0003458)1.63455668
162Focal segmental glomerulosclerosis (HP:0000097)1.63384690
163Abnormality of the distal phalanges of the toes (HP:0010182)1.62013370
164Mesangial abnormality (HP:0001966)1.61528932
165Distal lower limb amyotrophy (HP:0008944)1.60864490
166Abnormal blistering of the skin (HP:0008066)1.60375811
167Increased IgE level (HP:0003212)1.58426482
168Aplasia cutis congenita (HP:0001057)1.58327845
169Supraventricular tachycardia (HP:0004755)1.57985304
170Elevated erythrocyte sedimentation rate (HP:0003565)1.57197735
171Bundle branch block (HP:0011710)1.56920645
172Ankle contracture (HP:0006466)1.55924859
173Hemangiomatosis (HP:0007461)1.54904439
174Bicuspid aortic valve (HP:0001647)1.53457180
175Palpitations (HP:0001962)1.51301741
176Lip pit (HP:0100267)1.51280169
177Advanced eruption of teeth (HP:0006288)1.50555871
178Abnormality of oral frenula (HP:0000190)1.50242304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.37740497
2TIE13.30017664
3PRPF4B3.15664512
4ERN13.08048308
5RIPK13.06991579
6TRIB33.04979145
7TGFBR22.64377586
8EPHA22.61714553
9KDR2.60569605
10PKN22.57307391
11TTN2.31442027
12PTK62.26005338
13MAP3K32.05665107
14MAP3K101.96516608
15MST41.95265760
16DMPK1.91435494
17MST1R1.89287508
18FER1.87211231
19EPHB11.83007736
20KIT1.70003240
21STK101.65811647
22BLK1.61657322
23LRRK21.57916285
24MAP2K21.55259004
25LATS11.52556400
26TAOK21.52210686
27MATK1.49198229
28PDGFRA1.46162924
29MAP3K21.44934545
30FGFR41.40166280
31EPHB21.39364945
32TBK11.37009852
33CDC42BPA1.35901895
34PTK21.31528056
35LMTK21.30365531
36MAP2K31.29341129
37PRKG21.25115582
38IRAK11.23925026
39BMPR21.23039547
40IRAK41.22436760
41PDGFRB1.20073467
42FES1.19896097
43MAP3K141.19885040
44SCYL21.17898033
45LATS21.12349087
46FGFR31.11528099
47NME21.10813865
48GRK71.08833272
49TAOK11.07341499
50FRK1.05419909
51MAP3K71.05377496
52TYK21.05046554
53MAPKAPK31.04984117
54MAP3K61.04577225
55KSR21.02812366
56CSK1.01324195
57MAPK151.01161401
58FLT31.00346292
59BMX0.97400794
60EPHA30.97158369
61CSF1R0.96749006
62JAK10.94161716
63IRAK20.93012847
64MAP3K110.92708243
65PAK40.92570248
66SIK10.92285556
67CHUK0.89600440
68TGFBR10.89363121
69MET0.88149299
70MAP2K10.86250855
71PIM20.85693468
72TAOK30.85305631
73PDK20.84660524
74RPS6KA40.83905955
75PTK2B0.79965213
76TRPM70.77711112
77SYK0.77599879
78PRKD10.77388732
79JAK20.76568143
80DDR20.75794658
81ZAP700.75340552
82MARK20.75032538
83RET0.73422931
84RIPK40.71978048
85* MAP3K10.71309204
86GRK60.71272317
87ABL20.71138453
88BTK0.70218076
89SMG10.67885510
90HIPK20.67404543
91FGR0.64062476
92CDK120.63003061
93RPS6KC10.62234842
94RPS6KL10.62234842
95JAK30.59701584
96MAP4K10.59488853
97MAP2K60.59365324
98NEK90.59029751
99CDK60.57985819
100IKBKE0.56372685
101PRKCH0.55218425
102FGFR10.55030838
103PDK10.54741685
104EGFR0.54494314
105ALK0.54397263
106DAPK20.53205311
107HCK0.52988932
108RPS6KA20.52769698
109RPS6KB20.51703578
110STK240.51451087
111PAK20.49968224
112MAPK110.49896016
113LYN0.48819425
114LCK0.48700851
115GSK3A0.48131812
116ICK0.48050567
117MAPK40.47390647
118MTOR0.46880511
119PDPK10.46276784
120CAMK1D0.46065007
121PAK30.45707202
122ACVR1B0.45042891
123RPS6KA60.44747151
124MYLK0.44142655
125ITK0.44056074
126EEF2K0.43541879
127ERBB20.43539024
128SRC0.43502476
129CAMKK10.40886505
130MAP3K130.40550939
131PRKAA20.40419836
132MAP3K90.38335289
133PIK3CA0.37845876
134ERBB30.37569757
135MAPKAPK20.37422298
136IKBKB0.37374799
137RPS6KA10.37324261
138MOS0.37307806
139MAP3K80.37245615
140INSR0.36129851
141STK30.35948283
142MAPK120.34886700
143MARK30.34611506
144MAPK70.33855752

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.41529917
2Adherens junction_Homo sapiens_hsa045201.78654510
3Asthma_Homo sapiens_hsa053101.75956111
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75841478
5ECM-receptor interaction_Homo sapiens_hsa045121.74486847
6Leishmaniasis_Homo sapiens_hsa051401.71696495
7Leukocyte transendothelial migration_Homo sapiens_hsa046701.69795819
8Amoebiasis_Homo sapiens_hsa051461.67277420
9Osteoclast differentiation_Homo sapiens_hsa043801.66906419
10Focal adhesion_Homo sapiens_hsa045101.57902205
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.57173270
12Toxoplasmosis_Homo sapiens_hsa051451.55680039
13Proteoglycans in cancer_Homo sapiens_hsa052051.51986045
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51366181
15Allograft rejection_Homo sapiens_hsa053301.51262396
16Graft-versus-host disease_Homo sapiens_hsa053321.46867064
17TNF signaling pathway_Homo sapiens_hsa046681.44845989
18Dilated cardiomyopathy_Homo sapiens_hsa054141.40955710
19Small cell lung cancer_Homo sapiens_hsa052221.39724418
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.30562287
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27372827
22Malaria_Homo sapiens_hsa051441.25959708
23Insulin resistance_Homo sapiens_hsa049311.23580683
24Staphylococcus aureus infection_Homo sapiens_hsa051501.21115572
25Rheumatoid arthritis_Homo sapiens_hsa053231.20597882
26VEGF signaling pathway_Homo sapiens_hsa043701.20055387
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.19174939
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16550401
29Pertussis_Homo sapiens_hsa051331.15909450
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.14801315
31Autoimmune thyroid disease_Homo sapiens_hsa053201.12637483
32Prion diseases_Homo sapiens_hsa050201.11824532
33Renin-angiotensin system_Homo sapiens_hsa046141.11761806
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11450982
35Chronic myeloid leukemia_Homo sapiens_hsa052201.09654717
36Bladder cancer_Homo sapiens_hsa052191.08481071
37Salmonella infection_Homo sapiens_hsa051321.07840000
38Legionellosis_Homo sapiens_hsa051341.07281655
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06129740
40Type I diabetes mellitus_Homo sapiens_hsa049401.05372477
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03881178
42Mineral absorption_Homo sapiens_hsa049781.02951996
43Platelet activation_Homo sapiens_hsa046110.99883932
44Glycosaminoglycan degradation_Homo sapiens_hsa005310.99653093
45Tuberculosis_Homo sapiens_hsa051520.96421890
46Viral myocarditis_Homo sapiens_hsa054160.95584580
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93914258
48Protein digestion and absorption_Homo sapiens_hsa049740.93469725
49Fat digestion and absorption_Homo sapiens_hsa049750.92896147
50African trypanosomiasis_Homo sapiens_hsa051430.90787001
51Type II diabetes mellitus_Homo sapiens_hsa049300.90392880
52Rap1 signaling pathway_Homo sapiens_hsa040150.89393135
53Estrogen signaling pathway_Homo sapiens_hsa049150.88586630
54Tight junction_Homo sapiens_hsa045300.87315680
55GnRH signaling pathway_Homo sapiens_hsa049120.87263745
56Herpes simplex infection_Homo sapiens_hsa051680.86943851
57Hematopoietic cell lineage_Homo sapiens_hsa046400.86422885
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.85285143
59Renal cell carcinoma_Homo sapiens_hsa052110.84439863
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.84227516
61Histidine metabolism_Homo sapiens_hsa003400.83440252
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83189438
63Antigen processing and presentation_Homo sapiens_hsa046120.83128119
64Nitrogen metabolism_Homo sapiens_hsa009100.82486544
65Hepatitis C_Homo sapiens_hsa051600.79717783
66Pancreatic secretion_Homo sapiens_hsa049720.79187643
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.79013495
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77154337
69Acute myeloid leukemia_Homo sapiens_hsa052210.76949513
70* Dorso-ventral axis formation_Homo sapiens_hsa043200.76889848
71Prolactin signaling pathway_Homo sapiens_hsa049170.76236996
72Endometrial cancer_Homo sapiens_hsa052130.76111691
73Influenza A_Homo sapiens_hsa051640.75977988
74Pancreatic cancer_Homo sapiens_hsa052120.75638146
75Measles_Homo sapiens_hsa051620.74567731
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72782235
77Apoptosis_Homo sapiens_hsa042100.72073941
78Thyroid cancer_Homo sapiens_hsa052160.72021404
79MicroRNAs in cancer_Homo sapiens_hsa052060.71849500
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71255200
81B cell receptor signaling pathway_Homo sapiens_hsa046620.70433903
82Fructose and mannose metabolism_Homo sapiens_hsa000510.69886717
83Arachidonic acid metabolism_Homo sapiens_hsa005900.69668340
84Bile secretion_Homo sapiens_hsa049760.69208112
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68657112
86T cell receptor signaling pathway_Homo sapiens_hsa046600.68554391
87HIF-1 signaling pathway_Homo sapiens_hsa040660.68200917
88Arginine biosynthesis_Homo sapiens_hsa002200.67767262
89Notch signaling pathway_Homo sapiens_hsa043300.66754316
90Shigellosis_Homo sapiens_hsa051310.66672474
91Chemokine signaling pathway_Homo sapiens_hsa040620.66541555
92Gastric acid secretion_Homo sapiens_hsa049710.66390475
93Vitamin digestion and absorption_Homo sapiens_hsa049770.66178779
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65660482
95Renin secretion_Homo sapiens_hsa049240.65217596
96Starch and sucrose metabolism_Homo sapiens_hsa005000.64729072
97Endocytosis_Homo sapiens_hsa041440.62740945
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62687980
99Hippo signaling pathway_Homo sapiens_hsa043900.61785130
100Complement and coagulation cascades_Homo sapiens_hsa046100.61276408
101Hepatitis B_Homo sapiens_hsa051610.60584518
102Phagosome_Homo sapiens_hsa041450.60581364
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.60408351
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59520154
105Caffeine metabolism_Homo sapiens_hsa002320.59510485
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59483335
107FoxO signaling pathway_Homo sapiens_hsa040680.59148017
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58934921
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58903741
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57083069
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56634120
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56449130
113Lysosome_Homo sapiens_hsa041420.56230985
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.55946009
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55601220
116Pathways in cancer_Homo sapiens_hsa052000.54942889
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54458116
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54187175
119mTOR signaling pathway_Homo sapiens_hsa041500.53968659
120MAPK signaling pathway_Homo sapiens_hsa040100.53925610
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.53602847
122Galactose metabolism_Homo sapiens_hsa000520.52944368
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52862868
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52784755
125PPAR signaling pathway_Homo sapiens_hsa033200.52536956
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52269951
127Melanogenesis_Homo sapiens_hsa049160.52024447
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51972487
129Prostate cancer_Homo sapiens_hsa052150.51454066
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47521436
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.47055261
132Non-small cell lung cancer_Homo sapiens_hsa052230.46917370
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46577173
134Sphingolipid metabolism_Homo sapiens_hsa006000.46192019
135Phenylalanine metabolism_Homo sapiens_hsa003600.46188251
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45784960
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45738391
138Chemical carcinogenesis_Homo sapiens_hsa052040.42540330
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42366235

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