

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | fusion of sperm to egg plasma membrane (GO:0007342) | 9.80378157 |
| 2 | response to pheromone (GO:0019236) | 8.60509624 |
| 3 | chromosome condensation (GO:0030261) | 8.10556292 |
| 4 | plasma membrane fusion (GO:0045026) | 7.84535219 |
| 5 | sperm capacitation (GO:0048240) | 7.80843710 |
| 6 | DNA packaging (GO:0006323) | 7.77527771 |
| 7 | microtubule depolymerization (GO:0007019) | 7.74781804 |
| 8 | spermatid nucleus differentiation (GO:0007289) | 7.72668774 |
| 9 | spermatid development (GO:0007286) | 7.56017030 |
| 10 | single strand break repair (GO:0000012) | 7.24164201 |
| 11 | sperm-egg recognition (GO:0035036) | 6.86272652 |
| 12 | multicellular organism reproduction (GO:0032504) | 6.36571676 |
| 13 | protein polyglutamylation (GO:0018095) | 6.35538034 |
| 14 | binding of sperm to zona pellucida (GO:0007339) | 6.20541936 |
| 15 | rRNA methylation (GO:0031167) | 6.06057855 |
| 16 | reproduction (GO:0000003) | 6.01424384 |
| 17 | sexual reproduction (GO:0019953) | 5.93900795 |
| 18 | axonemal dynein complex assembly (GO:0070286) | 5.90084037 |
| 19 | microtubule polymerization or depolymerization (GO:0031109) | 5.74390043 |
| 20 | cell-cell recognition (GO:0009988) | 5.52101012 |
| 21 | calcium ion-dependent exocytosis (GO:0017156) | 5.36622624 |
| 22 | regulation of cilium movement (GO:0003352) | 5.28860398 |
| 23 | spermatogenesis (GO:0007283) | 5.25443005 |
| 24 | phosphatidylethanolamine biosynthetic process (GO:0006646) | 5.24794364 |
| 25 | male gamete generation (GO:0048232) | 5.23868846 |
| 26 | cell migration involved in gastrulation (GO:0042074) | 5.17476402 |
| 27 | motile cilium assembly (GO:0044458) | 5.05133211 |
| 28 | ribosomal small subunit biogenesis (GO:0042274) | 4.98414908 |
| 29 | microtubule severing (GO:0051013) | 4.89048386 |
| 30 | protein targeting to Golgi (GO:0000042) | 4.82184372 |
| 31 | phosphatidylethanolamine metabolic process (GO:0046337) | 4.80472611 |
| 32 | gamete generation (GO:0007276) | 4.77410657 |
| 33 | establishment of protein localization to Golgi (GO:0072600) | 4.66651075 |
| 34 | cell wall macromolecule catabolic process (GO:0016998) | 4.60170249 |
| 35 | maturation of SSU-rRNA (GO:0030490) | 4.58489856 |
| 36 | negative regulation of inclusion body assembly (GO:0090084) | 4.56935258 |
| 37 | centriole replication (GO:0007099) | 4.56173137 |
| 38 | single fertilization (GO:0007338) | 4.55788286 |
| 39 | cellular ketone body metabolic process (GO:0046950) | 4.48134363 |
| 40 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 4.43623000 |
| 41 | viral transcription (GO:0019083) | 4.40265008 |
| 42 | regulation of posttranscriptional gene silencing (GO:0060147) | 4.35777769 |
| 43 | regulation of gene silencing by miRNA (GO:0060964) | 4.35777769 |
| 44 | regulation of gene silencing by RNA (GO:0060966) | 4.35777769 |
| 45 | translational termination (GO:0006415) | 4.32477809 |
| 46 | positive regulation of Rab GTPase activity (GO:0032851) | 4.31602114 |
| 47 | regulation of Rab GTPase activity (GO:0032313) | 4.31602114 |
| 48 | cell wall macromolecule metabolic process (GO:0044036) | 4.27838918 |
| 49 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.21625698 |
| 50 | DNA replication initiation (GO:0006270) | 4.17655674 |
| 51 | * regulation of mesoderm development (GO:2000380) | 4.16912293 |
| 52 | centriole assembly (GO:0098534) | 4.16875894 |
| 53 | formation of translation preinitiation complex (GO:0001731) | 4.11440769 |
| 54 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.11012968 |
| 55 | ribosome assembly (GO:0042255) | 4.08148798 |
| 56 | germ cell development (GO:0007281) | 4.06798589 |
| 57 | chromatin silencing (GO:0006342) | 4.06715634 |
| 58 | protein localization to kinetochore (GO:0034501) | 4.06682130 |
| 59 | regulation of Wnt signaling pathway involved in heart development (GO:0003307) | 4.05778798 |
| 60 | DNA unwinding involved in DNA replication (GO:0006268) | 4.05625931 |
| 61 | mitotic metaphase plate congression (GO:0007080) | 4.04756039 |
| 62 | nucleosome disassembly (GO:0006337) | 4.02496218 |
| 63 | protein-DNA complex disassembly (GO:0032986) | 4.02496218 |
| 64 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.00519357 |
| 65 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.00519357 |
| 66 | establishment of integrated proviral latency (GO:0075713) | 4.00008387 |
| 67 | ribosomal large subunit biogenesis (GO:0042273) | 3.99452239 |
| 68 | ketone body metabolic process (GO:1902224) | 3.96981304 |
| 69 | DNA strand elongation (GO:0022616) | 3.96781307 |
| 70 | RNA destabilization (GO:0050779) | 3.94411592 |
| 71 | ribosome biogenesis (GO:0042254) | 3.93322466 |
| 72 | cilium or flagellum-dependent cell motility (GO:0001539) | 3.92937293 |
| 73 | nucleobase biosynthetic process (GO:0046112) | 3.92422779 |
| 74 | nodal signaling pathway (GO:0038092) | 3.91545006 |
| 75 | DNA replication checkpoint (GO:0000076) | 3.87989835 |
| 76 | translational elongation (GO:0006414) | 3.85446587 |
| 77 | regulation of microtubule-based movement (GO:0060632) | 3.82910671 |
| 78 | cellular process involved in reproduction in multicellular organism (GO:0022412) | 3.80571035 |
| 79 | cranial nerve morphogenesis (GO:0021602) | 3.76420353 |
| 80 | translational initiation (GO:0006413) | 3.76412387 |
| 81 | multicellular organismal reproductive process (GO:0048609) | 3.75387370 |
| 82 | ribosomal small subunit assembly (GO:0000028) | 3.75223207 |
| 83 | regulation of inclusion body assembly (GO:0090083) | 3.75190813 |
| 84 | nuclear pore organization (GO:0006999) | 3.74693528 |
| 85 | spliceosomal snRNP assembly (GO:0000387) | 3.73528494 |
| 86 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.72425039 |
| 87 | seminiferous tubule development (GO:0072520) | 3.66826571 |
| 88 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.66207482 |
| 89 | * regulation of transcription involved in cell fate commitment (GO:0060850) | 3.65990121 |
| 90 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.64384485 |
| 91 | pre-miRNA processing (GO:0031054) | 3.63819752 |
| 92 | signal transduction involved in regulation of gene expression (GO:0023019) | 3.59449247 |
| 93 | nucleus organization (GO:0006997) | 3.57477923 |
| 94 | DNA deamination (GO:0045006) | 3.55318163 |
| 95 | purine nucleobase biosynthetic process (GO:0009113) | 3.53626386 |
| 96 | fertilization (GO:0009566) | 3.52532257 |
| 97 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.51748306 |
| 98 | polyamine biosynthetic process (GO:0006596) | 3.51731639 |
| 99 | epithelial cilium movement (GO:0003351) | 3.51643936 |
| 100 | protein localization to chromosome, centromeric region (GO:0071459) | 3.50487169 |
| 101 | protein localization to Golgi apparatus (GO:0034067) | 3.48408076 |
| 102 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.47662405 |
| 103 | cellular protein complex disassembly (GO:0043624) | 3.46445958 |
| 104 | negative regulation of Rho protein signal transduction (GO:0035024) | 3.44819548 |
| 105 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 3.43821117 |
| 106 | rRNA processing (GO:0006364) | 3.43034294 |
| 107 | mitotic nuclear envelope disassembly (GO:0007077) | 3.42856432 |
| 108 | metaphase plate congression (GO:0051310) | 3.40925478 |
| 109 | negative regulation of mesenchymal cell apoptotic process (GO:2001054) | 3.40666412 |
| 110 | paraxial mesoderm development (GO:0048339) | 3.40650273 |
| 111 | nuclear pore complex assembly (GO:0051292) | 3.40338146 |
| 112 | spliceosomal complex assembly (GO:0000245) | 3.39253089 |
| 113 | protein targeting to ER (GO:0045047) | 3.38197468 |
| 114 | cotranslational protein targeting to membrane (GO:0006613) | 3.38073715 |
| 115 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.36414328 |
| 116 | viral life cycle (GO:0019058) | 3.35815531 |
| 117 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.32346310 |
| 118 | kinetochore assembly (GO:0051382) | 3.32292269 |
| 119 | rRNA metabolic process (GO:0016072) | 3.30746741 |
| 120 | secondary heart field specification (GO:0003139) | 3.29649858 |
| 121 | heart field specification (GO:0003128) | 3.29649858 |
| 122 | cerebral cortex neuron differentiation (GO:0021895) | 3.28234043 |
| 123 | coenzyme catabolic process (GO:0009109) | 3.27579860 |
| 124 | IMP biosynthetic process (GO:0006188) | 3.27320629 |
| 125 | kinetochore organization (GO:0051383) | 3.27114421 |
| 126 | chromatin remodeling at centromere (GO:0031055) | 3.22120021 |
| 127 | protein complex disassembly (GO:0043241) | 3.20586210 |
| 128 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.19500655 |
| 129 | cilium movement (GO:0003341) | 3.19178405 |
| 130 | negative regulation of cell fate specification (GO:0009996) | 3.19123398 |
| 131 | telomere maintenance via recombination (GO:0000722) | 3.17714212 |
| 132 | membrane protein intracellular domain proteolysis (GO:0031293) | 3.16466504 |
| 133 | membrane disassembly (GO:0030397) | 3.16138297 |
| 134 | nuclear envelope disassembly (GO:0051081) | 3.16138297 |
| 135 | CENP-A containing nucleosome assembly (GO:0034080) | 3.15820571 |
| 136 | histone exchange (GO:0043486) | 3.15477382 |
| 137 | protein localization to endoplasmic reticulum (GO:0070972) | 3.11769452 |
| 138 | rRNA modification (GO:0000154) | 3.11243476 |
| 139 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.10298792 |
| 140 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.10298792 |
| 141 | mitotic sister chromatid segregation (GO:0000070) | 3.09739933 |
| 142 | heterochromatin organization (GO:0070828) | 3.06978700 |
| 143 | positive regulation of cell size (GO:0045793) | 3.05932533 |
| 144 | organic cation transport (GO:0015695) | 3.04485748 |
| 145 | mitotic recombination (GO:0006312) | 3.01811355 |
| 146 | negative regulation of gene expression, epigenetic (GO:0045814) | 3.01488195 |
| 147 | glycerol ether metabolic process (GO:0006662) | 3.01231453 |
| 148 | macromolecular complex disassembly (GO:0032984) | 3.01117807 |
| 149 | regulation of centriole replication (GO:0046599) | 3.01034289 |
| 150 | positive regulation of guanylate cyclase activity (GO:0031284) | 3.00971665 |
| 151 | regulation of centrosome cycle (GO:0046605) | 3.00806314 |
| 152 | metanephric nephron tubule development (GO:0072234) | 3.00334662 |
| 153 | metanephric tubule development (GO:0072170) | 3.00334662 |
| 154 | cellular response to pH (GO:0071467) | 3.00109742 |
| 155 | establishment of viral latency (GO:0019043) | 2.98753850 |
| 156 | mesenchymal cell differentiation involved in renal system development (GO:2001012) | 2.98530466 |
| 157 | mesenchymal cell differentiation involved in kidney development (GO:0072161) | 2.98530466 |
| 158 | protein complex localization (GO:0031503) | 2.98487476 |
| 159 | lymph vessel development (GO:0001945) | 2.98408508 |
| 160 | translation (GO:0006412) | 2.98088491 |
| 161 | response to acidic pH (GO:0010447) | 2.96897346 |
| 162 | tooth mineralization (GO:0034505) | 2.95066460 |
| 163 | pseudouridine synthesis (GO:0001522) | 2.94884661 |
| 164 | DNA replication-independent nucleosome organization (GO:0034724) | 2.94868862 |
| 165 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.94868862 |
| 166 | mitotic G1 DNA damage checkpoint (GO:0031571) | 2.94747843 |
| 167 | telomere maintenance via telomere lengthening (GO:0010833) | 2.94515256 |
| 168 | establishment of chromosome localization (GO:0051303) | 2.94441391 |
| 169 | peptidyl-threonine dephosphorylation (GO:0035970) | 2.92530198 |
| 170 | muscle cell fate commitment (GO:0042693) | 2.92197661 |
| 171 | cellular component biogenesis (GO:0044085) | 2.91037830 |
| 172 | NAD biosynthetic process (GO:0009435) | 2.90969730 |
| 173 | cell differentiation involved in metanephros development (GO:0072202) | 2.90583869 |
| 174 | multicellular organismal development (GO:0007275) | 2.90305143 |
| 175 | termination of RNA polymerase III transcription (GO:0006386) | 2.90237778 |
| 176 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.90237778 |
| 177 | IMP metabolic process (GO:0046040) | 2.89249566 |
| 178 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.88524139 |
| 179 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.88447838 |
| 180 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.87475513 |
| 181 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.87475513 |
| 182 | viral mRNA export from host cell nucleus (GO:0046784) | 2.87446980 |
| 183 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.85665015 |
| 184 | outer ear morphogenesis (GO:0042473) | 2.85647517 |
| 185 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.84473303 |
| 186 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.82957896 |
| 187 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.82299220 |
| 188 | metanephric epithelium development (GO:0072207) | 2.80787149 |
| 189 | regulation of guanylate cyclase activity (GO:0031282) | 2.80083478 |
| 190 | ether metabolic process (GO:0018904) | 2.76174248 |
| 191 | detection of light stimulus involved in visual perception (GO:0050908) | 2.70798994 |
| 192 | detection of light stimulus involved in sensory perception (GO:0050962) | 2.70798994 |
| 193 | mitotic G1/S transition checkpoint (GO:0044819) | 2.70292376 |
| 194 | homeostasis of number of cells within a tissue (GO:0048873) | 2.70177189 |
| 195 | axoneme assembly (GO:0035082) | 2.69729275 |
| 196 | mitochondrial fission (GO:0000266) | 2.67630369 |
| 197 | acrosome reaction (GO:0007340) | 10.6059076 |
| 198 | sperm motility (GO:0030317) | 10.3578814 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.67094725 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.95086931 |
| 3 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.62831112 |
| 4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.54836710 |
| 5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.43699977 |
| 6 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.38652243 |
| 7 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 3.12017121 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.10988156 |
| 9 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.08016314 |
| 10 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.06323059 |
| 11 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.84849133 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.78571132 |
| 13 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.77684452 |
| 14 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.76979929 |
| 15 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.72200151 |
| 16 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 2.69917396 |
| 17 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.67756051 |
| 18 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.59897728 |
| 19 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.58116564 |
| 20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.55313858 |
| 21 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.43451467 |
| 22 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.42629063 |
| 23 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 2.40531033 |
| 24 | BCL6_27268052_Chip-Seq_Bcells_Human | 2.38867332 |
| 25 | * LXR_22292898_ChIP-Seq_THP-1_Human | 2.35740394 |
| 26 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 2.34690312 |
| 27 | E2F1_20622854_ChIP-Seq_HELA_Human | 2.34483714 |
| 28 | P68_20966046_ChIP-Seq_HELA_Human | 2.26062262 |
| 29 | ERA_21632823_ChIP-Seq_H3396_Human | 2.21447948 |
| 30 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 2.17124311 |
| 31 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.15415872 |
| 32 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.14359303 |
| 33 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.13225783 |
| 34 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 2.11140887 |
| 35 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 2.10926301 |
| 36 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 2.10926301 |
| 37 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 2.10926301 |
| 38 | BCOR_27268052_Chip-Seq_Bcells_Human | 2.09746781 |
| 39 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 2.09295725 |
| 40 | CTCF_27219007_Chip-Seq_Bcells_Human | 2.09274233 |
| 41 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 2.05112296 |
| 42 | PHF8_20622854_ChIP-Seq_HELA_Human | 2.04624671 |
| 43 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 2.01321910 |
| 44 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.97386892 |
| 45 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.97006846 |
| 46 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.95567828 |
| 47 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.92619197 |
| 48 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.92060673 |
| 49 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.91824822 |
| 50 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.91395282 |
| 51 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.90731819 |
| 52 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.89655314 |
| 53 | RAC3_21632823_ChIP-Seq_H3396_Human | 1.85826230 |
| 54 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.83914702 |
| 55 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.81587518 |
| 56 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.81495030 |
| 57 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.77328587 |
| 58 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.76360278 |
| 59 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.76009141 |
| 60 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.69413582 |
| 61 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.68887064 |
| 62 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.67863628 |
| 63 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.66897654 |
| 64 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.66328597 |
| 65 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.64420750 |
| 66 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.63977015 |
| 67 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.62608282 |
| 68 | P300_27268052_Chip-Seq_Bcells_Human | 1.62210482 |
| 69 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.62076142 |
| 70 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.62043878 |
| 71 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.61280091 |
| 72 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.60534973 |
| 73 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.60057477 |
| 74 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.60050394 |
| 75 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.59005296 |
| 76 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.58519661 |
| 77 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.58143621 |
| 78 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.57633345 |
| 79 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.57388614 |
| 80 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.56607593 |
| 81 | SA1_27219007_Chip-Seq_Bcells_Human | 1.56395433 |
| 82 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.55718430 |
| 83 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.54933430 |
| 84 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.53048833 |
| 85 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.52176237 |
| 86 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.51113593 |
| 87 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.50650333 |
| 88 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.47948091 |
| 89 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.47764541 |
| 90 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.44519726 |
| 91 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.44509811 |
| 92 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.43600621 |
| 93 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.41500457 |
| 94 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.39135237 |
| 95 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.37477823 |
| 96 | P53_21459846_ChIP-Seq_SAOS-2_Human | 1.36756093 |
| 97 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.35709648 |
| 98 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 1.35290609 |
| 99 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.34633394 |
| 100 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.34365266 |
| 101 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.33854638 |
| 102 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.32672167 |
| 103 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 1.32514436 |
| 104 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.30240026 |
| 105 | * SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.30130615 |
| 106 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.29724300 |
| 107 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.28478490 |
| 108 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.28265500 |
| 109 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.27518529 |
| 110 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.27405186 |
| 111 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.26332057 |
| 112 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.25479643 |
| 113 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 1.25173816 |
| 114 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 1.23905842 |
| 115 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.23681944 |
| 116 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.22943559 |
| 117 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.22471442 |
| 118 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.21198472 |
| 119 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.21198472 |
| 120 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.21116095 |
| 121 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.21116095 |
| 122 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.20932125 |
| 123 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.19737786 |
| 124 | FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.19657399 |
| 125 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 1.19545085 |
| 126 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.17532308 |
| 127 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.15815030 |
| 128 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.15809229 |
| 129 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 1.15368409 |
| 130 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.14475726 |
| 131 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.13765600 |
| 132 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.13540203 |
| 133 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.13073235 |
| 134 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.12918724 |
| 135 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.12885316 |
| 136 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 1.11418840 |
| 137 | * E2F1_17053090_ChIP-ChIP_MCF-7_Human | 1.09981118 |
| 138 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.09721063 |
| 139 | GATA3_21867929_ChIP-Seq_CD8_Mouse | 1.08995372 |
| 140 | * NANOG_18692474_ChIP-Seq_MEFs_Mouse | 1.08963105 |
| 141 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.07885503 |
| 142 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.06868823 |
| 143 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.06501767 |
| 144 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 1.06189813 |
| 145 | * POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 1.04204591 |
| 146 | * ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.03747041 |
| 147 | SOX11_22085726_ChIP-Seq_ESNs_Mouse | 1.03734305 |
| 148 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.03691717 |
| 149 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.03552911 |
| 150 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.03417606 |
| 151 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.03045447 |
| 152 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.02791451 |
| 153 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.02030735 |
| 154 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.01989520 |
| 155 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.99636152 |
| 156 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.98793776 |
| 157 | * SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.98140827 |
| 158 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 0.98047959 |
| 159 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.97909723 |
| 160 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.97361761 |
| 161 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.96216422 |
| 162 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.96000933 |
| 163 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 0.94865210 |
| 164 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.94614566 |
| 165 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.94451535 |
| 166 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.94083418 |
| 167 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93930247 |
| 168 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 0.93770996 |
| 169 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.93008306 |
| 170 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.92953589 |
| 171 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.92714159 |
| 172 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.92202728 |
| 173 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.92048948 |
| 174 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.90922229 |
| 175 | * BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.90708729 |
| 176 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.90679517 |
| 177 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.90516613 |
| 178 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.89693935 |
| 179 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.89680637 |
| 180 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.89061804 |
| 181 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.88360140 |
| 182 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.87647528 |
| 183 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.85870481 |
| 184 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.85436159 |
| 185 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.84943130 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003123_paternal_imprinting | 5.91340787 |
| 2 | MP0005377_hearing/vestibular/ear_phenot | 4.70388241 |
| 3 | MP0003878_abnormal_ear_physiology | 4.70388241 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 4.09410664 |
| 5 | MP0003693_abnormal_embryo_hatching | 3.87280323 |
| 6 | MP0003890_abnormal_embryonic-extraembry | 3.80850559 |
| 7 | MP0010094_abnormal_chromosome_stability | 3.17325931 |
| 8 | MP0004133_heterotaxia | 3.17268323 |
| 9 | MP0003077_abnormal_cell_cycle | 3.17047314 |
| 10 | MP0003121_genomic_imprinting | 3.17011114 |
| 11 | MP0008057_abnormal_DNA_replication | 3.16341180 |
| 12 | MP0003111_abnormal_nucleus_morphology | 3.03976644 |
| 13 | MP0001348_abnormal_lacrimal_gland | 2.73143299 |
| 14 | MP0010030_abnormal_orbit_morphology | 2.71853588 |
| 15 | MP0008932_abnormal_embryonic_tissue | 2.69483419 |
| 16 | MP0001730_embryonic_growth_arrest | 2.68454539 |
| 17 | MP0008058_abnormal_DNA_repair | 2.59680710 |
| 18 | MP0002653_abnormal_ependyma_morphology | 2.52813580 |
| 19 | MP0006292_abnormal_olfactory_placode | 2.46614780 |
| 20 | MP0002822_catalepsy | 2.44782970 |
| 21 | MP0008877_abnormal_DNA_methylation | 2.36105777 |
| 22 | MP0008007_abnormal_cellular_replicative | 2.30993763 |
| 23 | MP0010368_abnormal_lymphatic_system | 2.27108513 |
| 24 | MP0003806_abnormal_nucleotide_metabolis | 2.25097590 |
| 25 | MP0010352_gastrointestinal_tract_polyps | 2.19259980 |
| 26 | MP0003119_abnormal_digestive_system | 2.08821207 |
| 27 | * MP0001672_abnormal_embryogenesis/_devel | 2.08078025 |
| 28 | * MP0005380_embryogenesis_phenotype | 2.08078025 |
| 29 | MP0005379_endocrine/exocrine_gland_phen | 1.96702799 |
| 30 | MP0005248_abnormal_Harderian_gland | 1.96395064 |
| 31 | MP0003646_muscle_fatigue | 1.95354699 |
| 32 | MP0002084_abnormal_developmental_patter | 1.93361723 |
| 33 | MP0003122_maternal_imprinting | 1.90486185 |
| 34 | MP0003011_delayed_dark_adaptation | 1.85196033 |
| 35 | * MP0001697_abnormal_embryo_size | 1.83814279 |
| 36 | * MP0003984_embryonic_growth_retardation | 1.82399156 |
| 37 | * MP0002088_abnormal_embryonic_growth/wei | 1.81086317 |
| 38 | * MP0002085_abnormal_embryonic_tissue | 1.79533948 |
| 39 | MP0000350_abnormal_cell_proliferation | 1.75971346 |
| 40 | MP0003567_abnormal_fetal_cardiomyocyte | 1.72174574 |
| 41 | MP0001879_abnormal_lymphatic_vessel | 1.66680608 |
| 42 | MP0001293_anophthalmia | 1.65860200 |
| 43 | MP0000537_abnormal_urethra_morphology | 1.62718592 |
| 44 | MP0005410_abnormal_fertilization | 1.61134107 |
| 45 | MP0003315_abnormal_perineum_morphology | 1.58287030 |
| 46 | MP0004197_abnormal_fetal_growth/weight/ | 1.54361033 |
| 47 | * MP0002086_abnormal_extraembryonic_tissu | 1.53511071 |
| 48 | MP0002132_abnormal_respiratory_system | 1.47771458 |
| 49 | * MP0002080_prenatal_lethality | 1.46269127 |
| 50 | MP0005646_abnormal_pituitary_gland | 1.45801804 |
| 51 | MP0003937_abnormal_limbs/digits/tail_de | 1.45703216 |
| 52 | MP0009379_abnormal_foot_pigmentation | 1.44610678 |
| 53 | MP0002282_abnormal_trachea_morphology | 1.41488878 |
| 54 | MP0001968_abnormal_touch/_nociception | 1.34958238 |
| 55 | MP0000678_abnormal_parathyroid_gland | 1.34839407 |
| 56 | MP0002234_abnormal_pharynx_morphology | 1.29109643 |
| 57 | MP0002111_abnormal_tail_morphology | 1.27715565 |
| 58 | MP0000534_abnormal_ureter_morphology | 1.25255093 |
| 59 | MP0000049_abnormal_middle_ear | 1.24937405 |
| 60 | MP0005423_abnormal_somatic_nervous | 1.24806253 |
| 61 | MP0003718_maternal_effect | 1.22724517 |
| 62 | MP0009053_abnormal_anal_canal | 1.22473253 |
| 63 | MP0002210_abnormal_sex_determination | 1.17912192 |
| 64 | MP0003786_premature_aging | 1.17383815 |
| 65 | MP0000026_abnormal_inner_ear | 1.16023650 |
| 66 | MP0002102_abnormal_ear_morphology | 1.09916043 |
| 67 | MP0003938_abnormal_ear_development | 1.09403750 |
| 68 | MP0001485_abnormal_pinna_reflex | 1.08606100 |
| 69 | MP0005451_abnormal_body_composition | 1.07917760 |
| 70 | MP0002127_abnormal_cardiovascular_syste | 1.06883728 |
| 71 | MP0001929_abnormal_gametogenesis | 1.06371410 |
| 72 | MP0001145_abnormal_male_reproductive | 1.06112579 |
| 73 | * MP0000313_abnormal_cell_death | 1.01521118 |
| 74 | MP0003705_abnormal_hypodermis_morpholog | 0.99611321 |
| 75 | MP0005253_abnormal_eye_physiology | 0.98794422 |
| 76 | MP0003186_abnormal_redox_activity | 0.97802577 |
| 77 | MP0005367_renal/urinary_system_phenotyp | 0.97647673 |
| 78 | MP0000516_abnormal_urinary_system | 0.97647673 |
| 79 | MP0000428_abnormal_craniofacial_morphol | 0.97501152 |
| 80 | MP0003385_abnormal_body_wall | 0.97474705 |
| 81 | MP0005551_abnormal_eye_electrophysiolog | 0.97455706 |
| 82 | MP0002932_abnormal_joint_morphology | 0.97399003 |
| 83 | MP0002160_abnormal_reproductive_system | 0.97274412 |
| 84 | MP0003935_abnormal_craniofacial_develop | 0.95286201 |
| 85 | MP0000432_abnormal_head_morphology | 0.94997651 |
| 86 | MP0010307_abnormal_tumor_latency | 0.94426928 |
| 87 | MP0000566_synostosis | 0.94076511 |
| 88 | MP0002733_abnormal_thermal_nociception | 0.92531074 |
| 89 | MP0001905_abnormal_dopamine_level | 0.91600968 |
| 90 | MP0005391_vision/eye_phenotype | 0.91397223 |
| 91 | MP0003698_abnormal_male_reproductive | 0.90367829 |
| 92 | MP0003861_abnormal_nervous_system | 0.89878380 |
| 93 | MP0001727_abnormal_embryo_implantation | 0.88895323 |
| 94 | MP0009672_abnormal_birth_weight | 0.87994354 |
| 95 | MP0005623_abnormal_meninges_morphology | 0.87044558 |
| 96 | MP0004742_abnormal_vestibular_system | 0.86157365 |
| 97 | MP0001963_abnormal_hearing_physiology | 0.85622630 |
| 98 | MP0005083_abnormal_biliary_tract | 0.84583642 |
| 99 | MP0000372_irregular_coat_pigmentation | 0.83970661 |
| 100 | MP0000653_abnormal_sex_gland | 0.83715312 |
| 101 | MP0005670_abnormal_white_adipose | 0.83072959 |
| 102 | MP0002735_abnormal_chemical_nociception | 0.82307336 |
| 103 | MP0006072_abnormal_retinal_apoptosis | 0.81531727 |
| 104 | MP0003941_abnormal_skin_development | 0.81527901 |
| 105 | MP0001346_abnormal_lacrimal_gland | 0.81475314 |
| 106 | MP0000681_abnormal_thyroid_gland | 0.81416058 |
| 107 | MP0003566_abnormal_cell_adhesion | 0.81203920 |
| 108 | MP0005266_abnormal_metabolism | 0.80734298 |
| 109 | MP0002249_abnormal_larynx_morphology | 0.79959549 |
| 110 | MP0005499_abnormal_olfactory_system | 0.79089476 |
| 111 | MP0005394_taste/olfaction_phenotype | 0.79089476 |
| 112 | MP0002138_abnormal_hepatobiliary_system | 0.79063783 |
| 113 | MP0001849_ear_inflammation | 0.77472940 |
| 114 | MP0002557_abnormal_social/conspecific_i | 0.75039736 |
| 115 | * MP0002925_abnormal_cardiovascular_devel | 0.74806102 |
| 116 | MP0005645_abnormal_hypothalamus_physiol | 0.73851253 |
| 117 | MP0001286_abnormal_eye_development | 0.73435043 |
| 118 | MP0003942_abnormal_urinary_system | 0.73075282 |
| 119 | MP0005408_hypopigmentation | 0.72992749 |
| 120 | MP0002736_abnormal_nociception_after | 0.72989519 |
| 121 | MP0000358_abnormal_cell_content/ | 0.72737937 |
| 122 | MP0000955_abnormal_spinal_cord | 0.71944173 |
| 123 | MP0003755_abnormal_palate_morphology | 0.71669120 |
| 124 | MP0001764_abnormal_homeostasis | 0.70756921 |
| 125 | MP0005395_other_phenotype | 0.70568489 |
| 126 | MP0002114_abnormal_axial_skeleton | 0.70348686 |
| 127 | MP0000003_abnormal_adipose_tissue | 0.69197013 |
| 128 | MP0004264_abnormal_extraembryonic_tissu | 0.68726687 |
| 129 | MP0001765_abnormal_ion_homeostasis | 0.68175526 |
| 130 | MP0002938_white_spotting | 0.68035244 |
| 131 | MP0000762_abnormal_tongue_morphology | 0.67851078 |
| 132 | MP0002092_abnormal_eye_morphology | 0.67779456 |
| 133 | MP0002163_abnormal_gland_morphology | 0.67625368 |
| 134 | MP0002019_abnormal_tumor_incidence | 0.67366961 |
| 135 | MP0000750_abnormal_muscle_regeneration | 0.67185516 |
| 136 | MP0005384_cellular_phenotype | 0.66776598 |
| 137 | MP0008995_early_reproductive_senescence | 0.66363483 |
| 138 | MP0003283_abnormal_digestive_organ | 0.66150823 |
| 139 | MP0000013_abnormal_adipose_tissue | 0.65387090 |
| 140 | MP0002229_neurodegeneration | 0.64250385 |
| 141 | MP0008789_abnormal_olfactory_epithelium | 0.64226826 |
| 142 | MP0005023_abnormal_wound_healing | 0.63840600 |
| 143 | MP0005389_reproductive_system_phenotype | 0.63629195 |
| 144 | MP0001915_intracranial_hemorrhage | 0.63416513 |
| 145 | MP0006035_abnormal_mitochondrial_morpho | 0.62349515 |
| 146 | MP0002161_abnormal_fertility/fecundity | 0.62281190 |
| 147 | MP0003879_abnormal_hair_cell | 0.62089288 |
| 148 | MP0009278_abnormal_bone_marrow | 0.58270487 |
| 149 | MP0001486_abnormal_startle_reflex | 0.57648094 |
| 150 | MP0003136_yellow_coat_color | 0.55044991 |
| 151 | MP0005195_abnormal_posterior_eye | 0.54218494 |
| 152 | MP0005084_abnormal_gallbladder_morpholo | 0.53583136 |
| 153 | MP0001970_abnormal_pain_threshold | 0.51385876 |
| 154 | MP0005636_abnormal_mineral_homeostasis | 0.49258685 |
| 155 | MP0009046_muscle_twitch | 0.48297014 |
| 156 | MP0003137_abnormal_impulse_conducting | 0.47964669 |
| 157 | MP0000631_abnormal_neuroendocrine_gland | 0.47490288 |
| 158 | MP0006276_abnormal_autonomic_nervous | 0.47423094 |
| 159 | MP0004510_myositis | 0.46998750 |
| 160 | MP0009697_abnormal_copulation | 0.46302941 |
| 161 | MP0002697_abnormal_eye_size | 0.45744106 |
| 162 | MP0003959_abnormal_lean_body | 0.45166650 |
| 163 | MP0008569_lethality_at_weaning | 0.44902394 |
| 164 | MP0005310_abnormal_salivary_gland | 0.44773149 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Severe visual impairment (HP:0001141) | 6.97558044 |
| 2 | Chronic hepatic failure (HP:0100626) | 4.68025408 |
| 3 | Bony spicule pigmentary retinopathy (HP:0007737) | 4.63400237 |
| 4 | Attenuation of retinal blood vessels (HP:0007843) | 4.57835116 |
| 5 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 4.43828436 |
| 6 | Absent/shortened dynein arms (HP:0200106) | 4.43828436 |
| 7 | Renal Fanconi syndrome (HP:0001994) | 4.17959989 |
| 8 | Abnormal rod and cone electroretinograms (HP:0008323) | 3.98085535 |
| 9 | Male infertility (HP:0003251) | 3.90058354 |
| 10 | Birth length less than 3rd percentile (HP:0003561) | 3.87414418 |
| 11 | Breast hypoplasia (HP:0003187) | 3.83718997 |
| 12 | Colon cancer (HP:0003003) | 3.82698878 |
| 13 | Selective tooth agenesis (HP:0001592) | 3.77651095 |
| 14 | Abnormal ciliary motility (HP:0012262) | 3.75382862 |
| 15 | Enlarged epiphyses (HP:0010580) | 3.71819245 |
| 16 | Abnormality of abdominal situs (HP:0011620) | 3.70740023 |
| 17 | Abdominal situs inversus (HP:0003363) | 3.70740023 |
| 18 | Reticulocytopenia (HP:0001896) | 3.67692413 |
| 19 | Infertility (HP:0000789) | 3.61153152 |
| 20 | Abnormal respiratory motile cilium physiology (HP:0012261) | 3.53140225 |
| 21 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 3.49261789 |
| 22 | Carpal bone hypoplasia (HP:0001498) | 3.47002374 |
| 23 | Hyperthyroidism (HP:0000836) | 3.44498575 |
| 24 | Bell-shaped thorax (HP:0001591) | 3.39273526 |
| 25 | Generalized aminoaciduria (HP:0002909) | 3.38102765 |
| 26 | Supernumerary spleens (HP:0009799) | 3.37990225 |
| 27 | Abnormality of macular pigmentation (HP:0008002) | 3.33724688 |
| 28 | Rib fusion (HP:0000902) | 3.28985293 |
| 29 | Asymmetric septal hypertrophy (HP:0001670) | 3.28632399 |
| 30 | Absent radius (HP:0003974) | 3.24060799 |
| 31 | Abnormality of the fetal cardiovascular system (HP:0010948) | 3.22830828 |
| 32 | Abnormal umbilical cord blood vessels (HP:0011403) | 3.22830828 |
| 33 | Single umbilical artery (HP:0001195) | 3.22830828 |
| 34 | Aplasia/hypoplasia of the humerus (HP:0006507) | 3.19537998 |
| 35 | Double outlet right ventricle (HP:0001719) | 3.16872610 |
| 36 | Congenital malformation of the right heart (HP:0011723) | 3.16872610 |
| 37 | Abnormal respiratory epithelium morphology (HP:0012253) | 3.13926128 |
| 38 | Abnormal respiratory motile cilium morphology (HP:0005938) | 3.13926128 |
| 39 | Ependymoma (HP:0002888) | 3.10901299 |
| 40 | Sclerocornea (HP:0000647) | 3.10744955 |
| 41 | Abnormal connection of the cardiac segments (HP:0011545) | 3.06613784 |
| 42 | Abnormal ventriculo-arterial connection (HP:0011563) | 3.06613784 |
| 43 | Transposition of the great arteries (HP:0001669) | 3.06613784 |
| 44 | Occipital encephalocele (HP:0002085) | 3.05242278 |
| 45 | Abnormal lung lobation (HP:0002101) | 3.04859501 |
| 46 | Absent forearm bone (HP:0003953) | 3.02018173 |
| 47 | Aplasia involving forearm bones (HP:0009822) | 3.02018173 |
| 48 | Multiple enchondromatosis (HP:0005701) | 2.99931079 |
| 49 | Medulloblastoma (HP:0002885) | 2.98998878 |
| 50 | Nephronophthisis (HP:0000090) | 2.94569629 |
| 51 | Macrocytic anemia (HP:0001972) | 2.91695586 |
| 52 | Nasal polyposis (HP:0100582) | 2.90068800 |
| 53 | Pancreatic fibrosis (HP:0100732) | 2.88353193 |
| 54 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.88009691 |
| 55 | Impulsivity (HP:0100710) | 2.85016437 |
| 56 | Abnormality of urine glucose concentration (HP:0011016) | 2.79998295 |
| 57 | Glycosuria (HP:0003076) | 2.79998295 |
| 58 | Abnormal urine output (HP:0012590) | 2.76902368 |
| 59 | Breast aplasia (HP:0100783) | 2.76744373 |
| 60 | Patellar aplasia (HP:0006443) | 2.75941523 |
| 61 | True hermaphroditism (HP:0010459) | 2.74683494 |
| 62 | Abnormality of the costochondral junction (HP:0000919) | 2.72873100 |
| 63 | Hyperkalemia (HP:0002153) | 2.72763111 |
| 64 | Unilateral renal agenesis (HP:0000122) | 2.71940136 |
| 65 | Facial cleft (HP:0002006) | 2.69201173 |
| 66 | Oral leukoplakia (HP:0002745) | 2.67849831 |
| 67 | Renal dysplasia (HP:0000110) | 2.66287368 |
| 68 | Trismus (HP:0000211) | 2.66031522 |
| 69 | Fused cervical vertebrae (HP:0002949) | 2.65072913 |
| 70 | Rectal fistula (HP:0100590) | 2.63762906 |
| 71 | Rectovaginal fistula (HP:0000143) | 2.63762906 |
| 72 | Hypophosphatemic rickets (HP:0004912) | 2.62742714 |
| 73 | Abnormal spermatogenesis (HP:0008669) | 2.62284678 |
| 74 | Abnormality of renal resorption (HP:0011038) | 2.62249588 |
| 75 | Polydipsia (HP:0001959) | 2.61239346 |
| 76 | Abnormal drinking behavior (HP:0030082) | 2.61239346 |
| 77 | Abnormal number of incisors (HP:0011064) | 2.57951453 |
| 78 | Short humerus (HP:0005792) | 2.57457298 |
| 79 | Cerebral hypomyelination (HP:0006808) | 2.57347119 |
| 80 | Polyuria (HP:0000103) | 2.57298976 |
| 81 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.56902806 |
| 82 | Meckel diverticulum (HP:0002245) | 2.56191757 |
| 83 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 2.53367795 |
| 84 | Azoospermia (HP:0000027) | 2.49788606 |
| 85 | Abnormality of the nasal mucosa (HP:0000433) | 2.49574380 |
| 86 | Hypoplasia of the thymus (HP:0000778) | 2.47694306 |
| 87 | Resting tremor (HP:0002322) | 2.46510064 |
| 88 | Abnormality of the ileum (HP:0001549) | 2.44533651 |
| 89 | Rough bone trabeculation (HP:0100670) | 2.44116234 |
| 90 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.42795896 |
| 91 | Abnormal number of erythroid precursors (HP:0012131) | 2.40984800 |
| 92 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.40703575 |
| 93 | Portal hypertension (HP:0001409) | 2.39737952 |
| 94 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.37471870 |
| 95 | Asplenia (HP:0001746) | 2.36283757 |
| 96 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.36207233 |
| 97 | Potter facies (HP:0002009) | 2.36080538 |
| 98 | Facial shape deformation (HP:0011334) | 2.36080538 |
| 99 | Atresia of the external auditory canal (HP:0000413) | 2.35261537 |
| 100 | Preauricular skin tag (HP:0000384) | 2.34391243 |
| 101 | Abnormality of the labia minora (HP:0012880) | 2.34368941 |
| 102 | Embryonal renal neoplasm (HP:0011794) | 2.33640062 |
| 103 | Abnormality of the hepatic vasculature (HP:0006707) | 2.32789013 |
| 104 | Amelogenesis imperfecta (HP:0000705) | 2.32721589 |
| 105 | Sensory axonal neuropathy (HP:0003390) | 2.31603687 |
| 106 | Rhabdomyosarcoma (HP:0002859) | 2.30651173 |
| 107 | Abnormality of the anterior horn cell (HP:0006802) | 2.30184737 |
| 108 | Degeneration of anterior horn cells (HP:0002398) | 2.30184737 |
| 109 | Microretrognathia (HP:0000308) | 2.29454250 |
| 110 | Abnormality of the parathyroid morphology (HP:0011766) | 2.29368557 |
| 111 | Progressive external ophthalmoplegia (HP:0000590) | 2.29205692 |
| 112 | Missing ribs (HP:0000921) | 2.28580041 |
| 113 | Hypoplastic ischia (HP:0003175) | 2.26474446 |
| 114 | Absent thumb (HP:0009777) | 2.25891434 |
| 115 | Abnormality of renal excretion (HP:0011036) | 2.24500946 |
| 116 | Intestinal fistula (HP:0100819) | 2.24383065 |
| 117 | Atelectasis (HP:0100750) | 2.23888865 |
| 118 | Pendular nystagmus (HP:0012043) | 2.22848131 |
| 119 | Cleft eyelid (HP:0000625) | 2.22366267 |
| 120 | Decreased central vision (HP:0007663) | 2.22221606 |
| 121 | Delayed epiphyseal ossification (HP:0002663) | 2.21705239 |
| 122 | Hypoplastic left heart (HP:0004383) | 2.21207068 |
| 123 | Pancreatic cysts (HP:0001737) | 2.20731989 |
| 124 | Abnormality of the renal medulla (HP:0100957) | 2.20214017 |
| 125 | Seborrheic dermatitis (HP:0001051) | 2.19938783 |
| 126 | Truncus arteriosus (HP:0001660) | 2.19657750 |
| 127 | Vaginal fistula (HP:0004320) | 2.19350113 |
| 128 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.18811782 |
| 129 | Partial duplication of the phalanx of hand (HP:0009999) | 2.18286341 |
| 130 | Widely patent fontanelles and sutures (HP:0004492) | 2.17515569 |
| 131 | Partial duplication of thumb phalanx (HP:0009944) | 2.17467715 |
| 132 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.16128042 |
| 133 | Triphalangeal thumb (HP:0001199) | 2.15636092 |
| 134 | Stenosis of the external auditory canal (HP:0000402) | 2.15461546 |
| 135 | Skin tags (HP:0010609) | 2.15089365 |
| 136 | Pallor (HP:0000980) | 2.15055615 |
| 137 | Lipid accumulation in hepatocytes (HP:0006561) | 2.14679697 |
| 138 | Abnormality of the aortic arch (HP:0012303) | 2.13502501 |
| 139 | Vertebral fusion (HP:0002948) | 2.13366408 |
| 140 | Hypoplastic heart (HP:0001961) | 2.10454264 |
| 141 | Hypoparathyroidism (HP:0000829) | 2.09726077 |
| 142 | Chromsome breakage (HP:0040012) | 2.08451655 |
| 143 | Abnormality of dental color (HP:0011073) | 2.08294914 |
| 144 | Horseshoe kidney (HP:0000085) | 2.07474355 |
| 145 | Tubulointerstitial nephritis (HP:0001970) | 2.06848008 |
| 146 | Stage 5 chronic kidney disease (HP:0003774) | 2.05938449 |
| 147 | Hyperphosphaturia (HP:0003109) | 2.04761819 |
| 148 | Short 4th metacarpal (HP:0010044) | 2.03623953 |
| 149 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.03623953 |
| 150 | Tongue fasciculations (HP:0001308) | 2.01611132 |
| 151 | Intellectual disability, moderate (HP:0002342) | 2.01285665 |
| 152 | Hypertensive crisis (HP:0100735) | 2.01088494 |
| 153 | Supernumerary bones of the axial skeleton (HP:0009144) | 2.00467031 |
| 154 | Neoplasm of striated muscle (HP:0009728) | 1.99792326 |
| 155 | Cone-rod dystrophy (HP:0000548) | 1.99248758 |
| 156 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.98918723 |
| 157 | Hyponatremia (HP:0002902) | 1.98751644 |
| 158 | Proximal placement of thumb (HP:0009623) | 1.98240433 |
| 159 | Tracheoesophageal fistula (HP:0002575) | 1.98166402 |
| 160 | Deviation of the thumb (HP:0009603) | 1.97626309 |
| 161 | Shawl scrotum (HP:0000049) | 1.97576896 |
| 162 | Diastasis recti (HP:0001540) | 1.97017451 |
| 163 | Thin bony cortex (HP:0002753) | 1.96870416 |
| 164 | Increased hepatocellular lipid droplets (HP:0006565) | 1.96747759 |
| 165 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.95854051 |
| 166 | Preaxial foot polydactyly (HP:0001841) | 1.95439344 |
| 167 | Neoplasm of the pancreas (HP:0002894) | 1.95201501 |
| 168 | Renovascular hypertension (HP:0100817) | 1.95151541 |
| 169 | Hemivertebrae (HP:0002937) | 1.94986436 |
| 170 | Progressive cerebellar ataxia (HP:0002073) | 1.94698651 |
| 171 | Astrocytoma (HP:0009592) | 1.94429843 |
| 172 | Abnormality of the astrocytes (HP:0100707) | 1.94429843 |
| 173 | Testicular atrophy (HP:0000029) | 1.94126139 |
| 174 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.93850196 |
| 175 | Chronic bronchitis (HP:0004469) | 1.93805254 |
| 176 | Exertional dyspnea (HP:0002875) | 1.93791551 |
| 177 | Anencephaly (HP:0002323) | 1.92903984 |
| 178 | Tetany (HP:0001281) | 1.92886810 |
| 179 | Abnormality of the umbilical cord (HP:0010881) | 1.92782916 |
| 180 | Glossoptosis (HP:0000162) | 1.92760817 |
| 181 | Muscle fiber atrophy (HP:0100295) | 1.92751707 |
| 182 | Cerebellar dysplasia (HP:0007033) | 1.92087553 |
| 183 | Absent epiphyses (HP:0010577) | 1.91528907 |
| 184 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.91528907 |
| 185 | Abnormality of the lower motor neuron (HP:0002366) | 1.89226116 |
| 186 | Osteomalacia (HP:0002749) | 1.88242607 |
| 187 | Progressive sensorineural hearing impairment (HP:0000408) | 1.87946702 |
| 188 | Renal duplication (HP:0000075) | 1.87440246 |
| 189 | Myokymia (HP:0002411) | 1.87054762 |
| 190 | Ectopic kidney (HP:0000086) | 1.86825406 |
| 191 | Premature ovarian failure (HP:0008209) | 1.86570935 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.99964647 |
| 2 | MAP4K2 | 4.43328135 |
| 3 | WEE1 | 4.08949277 |
| 4 | TIE1 | 4.03908082 |
| 5 | CDC7 | 3.87819185 |
| 6 | PLK4 | 3.80869209 |
| 7 | DDR2 | 3.46422549 |
| 8 | EIF2AK1 | 3.03639617 |
| 9 | MAPK15 | 2.94548761 |
| 10 | TTK | 2.85620267 |
| 11 | LATS2 | 2.69052604 |
| 12 | NEK1 | 2.54078036 |
| 13 | SRPK1 | 2.43214250 |
| 14 | NEK2 | 2.35235752 |
| 15 | TSSK6 | 2.34219279 |
| 16 | VRK2 | 2.29072926 |
| 17 | INSRR | 2.27060462 |
| 18 | STK38 | 2.26936494 |
| 19 | TAF1 | 2.11153050 |
| 20 | CDK12 | 2.02335318 |
| 21 | NME2 | 1.93651766 |
| 22 | PLK1 | 1.89922977 |
| 23 | STK38L | 1.85488770 |
| 24 | ZAK | 1.85068510 |
| 25 | TESK1 | 1.84609339 |
| 26 | CDK7 | 1.81387479 |
| 27 | CAMK1G | 1.75434896 |
| 28 | TRIM28 | 1.69898934 |
| 29 | ACVR1B | 1.69657799 |
| 30 | PASK | 1.64595982 |
| 31 | VRK1 | 1.58416690 |
| 32 | PLK2 | 1.55065764 |
| 33 | STK10 | 1.54904812 |
| 34 | MAP3K8 | 1.53430046 |
| 35 | PLK3 | 1.49242829 |
| 36 | TGFBR1 | 1.46982725 |
| 37 | EIF2AK3 | 1.46562196 |
| 38 | EPHA2 | 1.46267581 |
| 39 | DYRK1B | 1.40455530 |
| 40 | CHEK2 | 1.39573272 |
| 41 | AURKB | 1.36606606 |
| 42 | AKT3 | 1.36568796 |
| 43 | CHEK1 | 1.36182044 |
| 44 | TESK2 | 1.34066346 |
| 45 | AURKA | 1.31833869 |
| 46 | MKNK1 | 1.27048069 |
| 47 | RPS6KB2 | 1.25270056 |
| 48 | ATR | 1.24823539 |
| 49 | BRSK2 | 1.23150876 |
| 50 | DYRK2 | 1.21697676 |
| 51 | PAK4 | 1.21195702 |
| 52 | KDR | 1.19745873 |
| 53 | CAMK1D | 1.17691177 |
| 54 | BRSK1 | 1.14224822 |
| 55 | PDPK1 | 1.08246122 |
| 56 | MAP2K7 | 1.07754512 |
| 57 | PRKD3 | 1.07231571 |
| 58 | DYRK3 | 1.05249458 |
| 59 | SMG1 | 1.03080610 |
| 60 | PAK1 | 0.95096382 |
| 61 | EPHB2 | 0.94611480 |
| 62 | PDK3 | 0.92107247 |
| 63 | PDK4 | 0.92107247 |
| 64 | NME1 | 0.92089406 |
| 65 | TAOK3 | 0.91229470 |
| 66 | BRAF | 0.90018168 |
| 67 | BCKDK | 0.89803787 |
| 68 | PDK1 | 0.88816850 |
| 69 | TLK1 | 0.87675723 |
| 70 | CDK2 | 0.85886805 |
| 71 | WNK1 | 0.82576610 |
| 72 | STK16 | 0.79111225 |
| 73 | CSNK2A2 | 0.78586870 |
| 74 | ATM | 0.78428308 |
| 75 | MAP3K11 | 0.75566063 |
| 76 | EIF2AK2 | 0.75180024 |
| 77 | STK24 | 0.74447935 |
| 78 | PBK | 0.74018409 |
| 79 | ALK | 0.73680353 |
| 80 | LRRK2 | 0.73116313 |
| 81 | CDK8 | 0.72881349 |
| 82 | PTK2B | 0.72793069 |
| 83 | ABL2 | 0.71752005 |
| 84 | MET | 0.69794511 |
| 85 | CSNK2A1 | 0.68868507 |
| 86 | CDK4 | 0.67145778 |
| 87 | PINK1 | 0.66418213 |
| 88 | PNCK | 0.66279593 |
| 89 | CLK1 | 0.64799593 |
| 90 | ERN1 | 0.64220792 |
| 91 | CSNK1E | 0.64165971 |
| 92 | CDK1 | 0.63869474 |
| 93 | BMPR1B | 0.63101471 |
| 94 | RPS6KA2 | 0.61926616 |
| 95 | MAP2K2 | 0.60216503 |
| 96 | MAP2K4 | 0.60132363 |
| 97 | PDK2 | 0.58133395 |
| 98 | MST1R | 0.56066437 |
| 99 | ICK | 0.55909561 |
| 100 | STK3 | 0.55732831 |
| 101 | MAP3K4 | 0.54995916 |
| 102 | RPS6KL1 | 0.54959320 |
| 103 | RPS6KC1 | 0.54959320 |
| 104 | STK4 | 0.51982586 |
| 105 | RPS6KA6 | 0.51763621 |
| 106 | WNK4 | 0.51209160 |
| 107 | SCYL2 | 0.49055082 |
| 108 | GRK6 | 0.48908021 |
| 109 | CDK19 | 0.48126315 |
| 110 | PIK3CG | 0.47281355 |
| 111 | YES1 | 0.46988773 |
| 112 | BRD4 | 0.45534529 |
| 113 | PRKAA2 | 0.44641909 |
| 114 | PRKG2 | 0.44305889 |
| 115 | MELK | 0.44270456 |
| 116 | PKN2 | 0.43629504 |
| 117 | ILK | 0.43484951 |
| 118 | AKT2 | 0.42677943 |
| 119 | RPS6KA1 | 0.42665108 |
| 120 | CAMK1 | 0.42061604 |
| 121 | PRKCI | 0.41991895 |
| 122 | STK39 | 0.41966199 |
| 123 | GRK5 | 0.41534471 |
| 124 | MAP3K3 | 0.40797129 |
| 125 | FGFR1 | 0.38997471 |
| 126 | CDK11A | 0.38419775 |
| 127 | CDK15 | 0.37364722 |
| 128 | MTOR | 0.37223849 |
| 129 | MAP4K1 | 0.36700945 |
| 130 | RPS6KA4 | 0.36519965 |
| 131 | CDK14 | 0.36271200 |
| 132 | MKNK2 | 0.35954874 |
| 133 | CSNK1G3 | 0.35177018 |
| 134 | NUAK1 | 0.34980720 |
| 135 | RPS6KA5 | 0.34080069 |
| 136 | CDK18 | 0.34070198 |
| 137 | LIMK1 | 0.33430435 |
| 138 | FLT3 | 0.32603391 |
| 139 | PIM1 | 0.32102254 |
| 140 | PRKDC | 0.31829974 |
| 141 | TEC | 0.31483894 |
| 142 | MAP3K1 | 0.30305932 |
| 143 | GSK3B | 0.27823774 |
| 144 | CDK6 | 0.27069185 |
| 145 | WNK3 | 0.26533370 |
| 146 | CSNK1G2 | 0.24968305 |
| 147 | CAMK4 | 0.24078646 |
| 148 | PAK2 | 0.23981991 |
| 149 | TNK2 | 0.22839208 |
| 150 | TRIB3 | 0.22492817 |
| 151 | PRKG1 | 0.22451475 |
| 152 | DAPK1 | 0.22327142 |
| 153 | MAP2K3 | 0.22162077 |
| 154 | GRK1 | 0.22115760 |
| 155 | CSNK1A1L | 0.21298334 |
| 156 | MAPK8 | 0.21128369 |
| 157 | SIK2 | 0.20749058 |
| 158 | CAMKK2 | 0.20684241 |
| 159 | ADRBK2 | 0.19848314 |
| 160 | AKT1 | 0.18928420 |
| 161 | RIPK1 | 0.18692143 |
| 162 | MAPK11 | 0.18180588 |
| 163 | PIM2 | 0.17185156 |
| 164 | MAPK1 | 0.17005628 |
| 165 | HIPK2 | 0.16860670 |
| 166 | GRK7 | 0.16446410 |
| 167 | PRKCB | 0.15668054 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 5.88727602 |
| 2 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 5.53357823 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 4.53617876 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 4.44585513 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.12269127 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 3.87594104 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 3.76632501 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 3.64274007 |
| 9 | Proteasome_Homo sapiens_hsa03050 | 3.55984446 |
| 10 | RNA transport_Homo sapiens_hsa03013 | 3.23340471 |
| 11 | One carbon pool by folate_Homo sapiens_hsa00670 | 3.11566787 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.74500080 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 2.74340532 |
| 14 | Base excision repair_Homo sapiens_hsa03410 | 2.45717370 |
| 15 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.41714390 |
| 16 | Olfactory transduction_Homo sapiens_hsa04740 | 2.40876903 |
| 17 | Cell cycle_Homo sapiens_hsa04110 | 2.34813537 |
| 18 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.31027715 |
| 19 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.30467763 |
| 20 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.04937079 |
| 21 | RNA degradation_Homo sapiens_hsa03018 | 1.94310870 |
| 22 | Basal transcription factors_Homo sapiens_hsa03022 | 1.92610569 |
| 23 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.92198566 |
| 24 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.84655559 |
| 25 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.75145979 |
| 26 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.74292473 |
| 27 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.63409161 |
| 28 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.50839947 |
| 29 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.49689883 |
| 30 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.47768589 |
| 31 | Purine metabolism_Homo sapiens_hsa00230 | 1.47478786 |
| 32 | Phototransduction_Homo sapiens_hsa04744 | 1.34423690 |
| 33 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.28824150 |
| 34 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.25441868 |
| 35 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.22752871 |
| 36 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.20299366 |
| 37 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.18077934 |
| 38 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.17000242 |
| 39 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.15236734 |
| 40 | Huntingtons disease_Homo sapiens_hsa05016 | 1.12622571 |
| 41 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.09514072 |
| 42 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.09296362 |
| 43 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.04298883 |
| 44 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.03218062 |
| 45 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.99726086 |
| 46 | Taste transduction_Homo sapiens_hsa04742 | 0.99172358 |
| 47 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.96659521 |
| 48 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.96457064 |
| 49 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.96225255 |
| 50 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.93000590 |
| 51 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.92852643 |
| 52 | Carbon metabolism_Homo sapiens_hsa01200 | 0.90956703 |
| 53 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.90587736 |
| 54 | Parkinsons disease_Homo sapiens_hsa05012 | 0.88916628 |
| 55 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.82876499 |
| 56 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.82852717 |
| 57 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.81067705 |
| 58 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.80193863 |
| 59 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.78909653 |
| 60 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.77842475 |
| 61 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.77819261 |
| 62 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.76981082 |
| 63 | Peroxisome_Homo sapiens_hsa04146 | 0.76374637 |
| 64 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.76090089 |
| 65 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.73197289 |
| 66 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.71926470 |
| 67 | Nicotine addiction_Homo sapiens_hsa05033 | 0.71752136 |
| 68 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.71132221 |
| 69 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.66290961 |
| 70 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.66020779 |
| 71 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.63993666 |
| 72 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.63371640 |
| 73 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.63161905 |
| 74 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.59368288 |
| 75 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.58888166 |
| 76 | Endocytosis_Homo sapiens_hsa04144 | 0.57921752 |
| 77 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.56917240 |
| 78 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.56531507 |
| 79 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.53487636 |
| 80 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.53054446 |
| 81 | Thyroid cancer_Homo sapiens_hsa05216 | 0.52980267 |
| 82 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.52197713 |
| 83 | Morphine addiction_Homo sapiens_hsa05032 | 0.51941958 |
| 84 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.51489603 |
| 85 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.50980014 |
| 86 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.50951933 |
| 87 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.50858662 |
| 88 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.50190181 |
| 89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.48871536 |
| 90 | Adherens junction_Homo sapiens_hsa04520 | 0.48311714 |
| 91 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.47290127 |
| 92 | HTLV-I infection_Homo sapiens_hsa05166 | 0.46710572 |
| 93 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.46318860 |
| 94 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.45804675 |
| 95 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.43220561 |
| 96 | Tight junction_Homo sapiens_hsa04530 | 0.42623949 |
| 97 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.41556719 |
| 98 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.40658085 |
| 99 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.40536598 |
| 100 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.40499656 |
| 101 | Insulin secretion_Homo sapiens_hsa04911 | 0.40369481 |
| 102 | ABC transporters_Homo sapiens_hsa02010 | 0.39722168 |
| 103 | Sulfur relay system_Homo sapiens_hsa04122 | 0.37723880 |
| 104 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.36505919 |
| 105 | Metabolic pathways_Homo sapiens_hsa01100 | 0.35639479 |
| 106 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.35336976 |
| 107 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.34979677 |
| 108 | Melanoma_Homo sapiens_hsa05218 | 0.33220682 |
| 109 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.31932721 |
| 110 | Pathways in cancer_Homo sapiens_hsa05200 | 0.31302738 |
| 111 | Protein export_Homo sapiens_hsa03060 | 0.30486769 |
| 112 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.29919141 |
| 113 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.29309454 |
| 114 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.29188417 |
| 115 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.29128159 |
| 116 | Alzheimers disease_Homo sapiens_hsa05010 | 0.28816990 |
| 117 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.26169587 |
| 118 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.25303577 |
| 119 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.23059052 |
| 120 | Salivary secretion_Homo sapiens_hsa04970 | 0.22275665 |
| 121 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.22135763 |
| 122 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.21632195 |
| 123 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.20828370 |
| 124 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.20824615 |
| 125 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.19645902 |
| 126 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.19482745 |
| 127 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.19092984 |
| 128 | Alcoholism_Homo sapiens_hsa05034 | 0.18263673 |
| 129 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.17904329 |
| 130 | Bladder cancer_Homo sapiens_hsa05219 | 0.17711241 |
| 131 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.16670853 |
| 132 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.15810293 |
| 133 | GABAergic synapse_Homo sapiens_hsa04727 | 0.15765461 |
| 134 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.15272629 |
| 135 | Galactose metabolism_Homo sapiens_hsa00052 | 0.13478820 |
| 136 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.12448749 |
| 137 | Lysine degradation_Homo sapiens_hsa00310 | 0.11591313 |
| 138 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.11082044 |
| 139 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.10734635 |
| 140 | Retinol metabolism_Homo sapiens_hsa00830 | 0.09125672 |
| 141 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.08549693 |
| 142 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.08454439 |
| 143 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.07763193 |
| 144 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.06421926 |
| 145 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.03945921 |

