ETV2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.80378157
2response to pheromone (GO:0019236)8.60509624
3chromosome condensation (GO:0030261)8.10556292
4plasma membrane fusion (GO:0045026)7.84535219
5sperm capacitation (GO:0048240)7.80843710
6DNA packaging (GO:0006323)7.77527771
7microtubule depolymerization (GO:0007019)7.74781804
8spermatid nucleus differentiation (GO:0007289)7.72668774
9spermatid development (GO:0007286)7.56017030
10single strand break repair (GO:0000012)7.24164201
11sperm-egg recognition (GO:0035036)6.86272652
12multicellular organism reproduction (GO:0032504)6.36571676
13protein polyglutamylation (GO:0018095)6.35538034
14binding of sperm to zona pellucida (GO:0007339)6.20541936
15rRNA methylation (GO:0031167)6.06057855
16reproduction (GO:0000003)6.01424384
17sexual reproduction (GO:0019953)5.93900795
18axonemal dynein complex assembly (GO:0070286)5.90084037
19microtubule polymerization or depolymerization (GO:0031109)5.74390043
20cell-cell recognition (GO:0009988)5.52101012
21calcium ion-dependent exocytosis (GO:0017156)5.36622624
22regulation of cilium movement (GO:0003352)5.28860398
23spermatogenesis (GO:0007283)5.25443005
24phosphatidylethanolamine biosynthetic process (GO:0006646)5.24794364
25male gamete generation (GO:0048232)5.23868846
26cell migration involved in gastrulation (GO:0042074)5.17476402
27motile cilium assembly (GO:0044458)5.05133211
28ribosomal small subunit biogenesis (GO:0042274)4.98414908
29microtubule severing (GO:0051013)4.89048386
30protein targeting to Golgi (GO:0000042)4.82184372
31phosphatidylethanolamine metabolic process (GO:0046337)4.80472611
32gamete generation (GO:0007276)4.77410657
33establishment of protein localization to Golgi (GO:0072600)4.66651075
34cell wall macromolecule catabolic process (GO:0016998)4.60170249
35maturation of SSU-rRNA (GO:0030490)4.58489856
36negative regulation of inclusion body assembly (GO:0090084)4.56935258
37centriole replication (GO:0007099)4.56173137
38single fertilization (GO:0007338)4.55788286
39cellular ketone body metabolic process (GO:0046950)4.48134363
40retrograde transport, vesicle recycling within Golgi (GO:0000301)4.43623000
41viral transcription (GO:0019083)4.40265008
42regulation of gene silencing by RNA (GO:0060966)4.35777769
43regulation of posttranscriptional gene silencing (GO:0060147)4.35777769
44regulation of gene silencing by miRNA (GO:0060964)4.35777769
45translational termination (GO:0006415)4.32477809
46regulation of Rab GTPase activity (GO:0032313)4.31602114
47positive regulation of Rab GTPase activity (GO:0032851)4.31602114
48cell wall macromolecule metabolic process (GO:0044036)4.27838918
49DNA strand elongation involved in DNA replication (GO:0006271)4.21625698
50DNA replication initiation (GO:0006270)4.17655674
51* regulation of mesoderm development (GO:2000380)4.16912293
52centriole assembly (GO:0098534)4.16875894
53formation of translation preinitiation complex (GO:0001731)4.11440769
54ribonucleoprotein complex biogenesis (GO:0022613)4.11012968
55ribosome assembly (GO:0042255)4.08148798
56germ cell development (GO:0007281)4.06798589
57chromatin silencing (GO:0006342)4.06715634
58protein localization to kinetochore (GO:0034501)4.06682130
59regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.05778798
60DNA unwinding involved in DNA replication (GO:0006268)4.05625931
61mitotic metaphase plate congression (GO:0007080)4.04756039
62protein-DNA complex disassembly (GO:0032986)4.02496218
63nucleosome disassembly (GO:0006337)4.02496218
64DNA replication-dependent nucleosome assembly (GO:0006335)4.00519357
65DNA replication-dependent nucleosome organization (GO:0034723)4.00519357
66establishment of integrated proviral latency (GO:0075713)4.00008387
67ribosomal large subunit biogenesis (GO:0042273)3.99452239
68ketone body metabolic process (GO:1902224)3.96981304
69DNA strand elongation (GO:0022616)3.96781307
70RNA destabilization (GO:0050779)3.94411592
71ribosome biogenesis (GO:0042254)3.93322466
72cilium or flagellum-dependent cell motility (GO:0001539)3.92937293
73nucleobase biosynthetic process (GO:0046112)3.92422779
74nodal signaling pathway (GO:0038092)3.91545006
75DNA replication checkpoint (GO:0000076)3.87989835
76translational elongation (GO:0006414)3.85446587
77regulation of microtubule-based movement (GO:0060632)3.82910671
78cellular process involved in reproduction in multicellular organism (GO:0022412)3.80571035
79cranial nerve morphogenesis (GO:0021602)3.76420353
80translational initiation (GO:0006413)3.76412387
81multicellular organismal reproductive process (GO:0048609)3.75387370
82ribosomal small subunit assembly (GO:0000028)3.75223207
83regulation of inclusion body assembly (GO:0090083)3.75190813
84nuclear pore organization (GO:0006999)3.74693528
85spliceosomal snRNP assembly (GO:0000387)3.73528494
86folic acid-containing compound biosynthetic process (GO:0009396)3.72425039
87seminiferous tubule development (GO:0072520)3.66826571
88nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.66207482
89* regulation of transcription involved in cell fate commitment (GO:0060850)3.65990121
90telomere maintenance via semi-conservative replication (GO:0032201)3.64384485
91pre-miRNA processing (GO:0031054)3.63819752
92signal transduction involved in regulation of gene expression (GO:0023019)3.59449247
93nucleus organization (GO:0006997)3.57477923
94DNA deamination (GO:0045006)3.55318163
95purine nucleobase biosynthetic process (GO:0009113)3.53626386
96fertilization (GO:0009566)3.52532257
97regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.51748306
98polyamine biosynthetic process (GO:0006596)3.51731639
99epithelial cilium movement (GO:0003351)3.51643936
100protein localization to chromosome, centromeric region (GO:0071459)3.50487169
101protein localization to Golgi apparatus (GO:0034067)3.48408076
102SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.47662405
103cellular protein complex disassembly (GO:0043624)3.46445958
104negative regulation of Rho protein signal transduction (GO:0035024)3.44819548
105cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.43821117
106rRNA processing (GO:0006364)3.43034294
107mitotic nuclear envelope disassembly (GO:0007077)3.42856432
108metaphase plate congression (GO:0051310)3.40925478
109negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.40666412
110paraxial mesoderm development (GO:0048339)3.40650273
111nuclear pore complex assembly (GO:0051292)3.40338146
112spliceosomal complex assembly (GO:0000245)3.39253089
113protein targeting to ER (GO:0045047)3.38197468
114cotranslational protein targeting to membrane (GO:0006613)3.38073715
115deoxyribonucleotide biosynthetic process (GO:0009263)3.36414328
116viral life cycle (GO:0019058)3.35815531
117pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.32346310
118kinetochore assembly (GO:0051382)3.32292269
119rRNA metabolic process (GO:0016072)3.30746741
120heart field specification (GO:0003128)3.29649858
121secondary heart field specification (GO:0003139)3.29649858
122cerebral cortex neuron differentiation (GO:0021895)3.28234043
123coenzyme catabolic process (GO:0009109)3.27579860
124IMP biosynthetic process (GO:0006188)3.27320629
125kinetochore organization (GO:0051383)3.27114421
126chromatin remodeling at centromere (GO:0031055)3.22120021
127protein complex disassembly (GO:0043241)3.20586210
128establishment of protein localization to endoplasmic reticulum (GO:0072599)3.19500655
129cilium movement (GO:0003341)3.19178405
130negative regulation of cell fate specification (GO:0009996)3.19123398
131telomere maintenance via recombination (GO:0000722)3.17714212
132membrane protein intracellular domain proteolysis (GO:0031293)3.16466504
133nuclear envelope disassembly (GO:0051081)3.16138297
134membrane disassembly (GO:0030397)3.16138297
135CENP-A containing nucleosome assembly (GO:0034080)3.15820571
136histone exchange (GO:0043486)3.15477382
137protein localization to endoplasmic reticulum (GO:0070972)3.11769452
138rRNA modification (GO:0000154)3.11243476
139somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10298792
140somatic hypermutation of immunoglobulin genes (GO:0016446)3.10298792
141mitotic sister chromatid segregation (GO:0000070)3.09739933
142heterochromatin organization (GO:0070828)3.06978700
143positive regulation of cell size (GO:0045793)3.05932533
144organic cation transport (GO:0015695)3.04485748
145mitotic recombination (GO:0006312)3.01811355
146negative regulation of gene expression, epigenetic (GO:0045814)3.01488195
147glycerol ether metabolic process (GO:0006662)3.01231453
148macromolecular complex disassembly (GO:0032984)3.01117807
149regulation of centriole replication (GO:0046599)3.01034289
150positive regulation of guanylate cyclase activity (GO:0031284)3.00971665
151regulation of centrosome cycle (GO:0046605)3.00806314
152metanephric tubule development (GO:0072170)3.00334662
153metanephric nephron tubule development (GO:0072234)3.00334662
154cellular response to pH (GO:0071467)3.00109742
155establishment of viral latency (GO:0019043)2.98753850
156mesenchymal cell differentiation involved in kidney development (GO:0072161)2.98530466
157mesenchymal cell differentiation involved in renal system development (GO:2001012)2.98530466
158protein complex localization (GO:0031503)2.98487476
159lymph vessel development (GO:0001945)2.98408508
160translation (GO:0006412)2.98088491
161response to acidic pH (GO:0010447)2.96897346
162tooth mineralization (GO:0034505)2.95066460
163pseudouridine synthesis (GO:0001522)2.94884661
164DNA replication-independent nucleosome assembly (GO:0006336)2.94868862
165DNA replication-independent nucleosome organization (GO:0034724)2.94868862
166mitotic G1 DNA damage checkpoint (GO:0031571)2.94747843
167telomere maintenance via telomere lengthening (GO:0010833)2.94515256
168establishment of chromosome localization (GO:0051303)2.94441391
169peptidyl-threonine dephosphorylation (GO:0035970)2.92530198
170muscle cell fate commitment (GO:0042693)2.92197661
171cellular component biogenesis (GO:0044085)2.91037830
172NAD biosynthetic process (GO:0009435)2.90969730
173cell differentiation involved in metanephros development (GO:0072202)2.90583869
174multicellular organismal development (GO:0007275)2.90305143
175transcription elongation from RNA polymerase III promoter (GO:0006385)2.90237778
176termination of RNA polymerase III transcription (GO:0006386)2.90237778
177IMP metabolic process (GO:0046040)2.89249566
178nuclear-transcribed mRNA catabolic process (GO:0000956)2.88524139
179pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.88447838
1802-deoxyribonucleotide biosynthetic process (GO:0009265)2.87475513
181deoxyribose phosphate biosynthetic process (GO:0046385)2.87475513
182viral mRNA export from host cell nucleus (GO:0046784)2.87446980
183deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85665015
184outer ear morphogenesis (GO:0042473)2.85647517
185transcription-coupled nucleotide-excision repair (GO:0006283)2.84473303
186negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82957896
187regulation of nuclear cell cycle DNA replication (GO:0033262)2.82299220
188metanephric epithelium development (GO:0072207)2.80787149
189regulation of guanylate cyclase activity (GO:0031282)2.80083478
190ether metabolic process (GO:0018904)2.76174248
191detection of light stimulus involved in sensory perception (GO:0050962)2.70798994
192detection of light stimulus involved in visual perception (GO:0050908)2.70798994
193mitotic G1/S transition checkpoint (GO:0044819)2.70292376
194homeostasis of number of cells within a tissue (GO:0048873)2.70177189
195axoneme assembly (GO:0035082)2.69729275
196mitochondrial fission (GO:0000266)2.67630369
197acrosome reaction (GO:0007340)10.6059076
198sperm motility (GO:0030317)10.3578814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.67094725
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.95086931
3MYC_19079543_ChIP-ChIP_MESCs_Mouse3.62831112
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.54836710
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43699977
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.38652243
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.12017121
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.10988156
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08016314
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.06323059
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84849133
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78571132
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.77684452
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.76979929
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.72200151
16ELF1_20517297_ChIP-Seq_JURKAT_Human2.69917396
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67756051
18XRN2_22483619_ChIP-Seq_HELA_Human2.59897728
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.58116564
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55313858
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43451467
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42629063
23RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.40531033
24BCL6_27268052_Chip-Seq_Bcells_Human2.38867332
25* LXR_22292898_ChIP-Seq_THP-1_Human2.35740394
26EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.34690312
27E2F1_20622854_ChIP-Seq_HELA_Human2.34483714
28P68_20966046_ChIP-Seq_HELA_Human2.26062262
29ERA_21632823_ChIP-Seq_H3396_Human2.21447948
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.17124311
31STAT6_21828071_ChIP-Seq_BEAS2B_Human2.15415872
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14359303
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13225783
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.11140887
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.10926301
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.10926301
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.10926301
38BCOR_27268052_Chip-Seq_Bcells_Human2.09746781
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.09295725
40CTCF_27219007_Chip-Seq_Bcells_Human2.09274233
41NANOG_18555785_ChIP-Seq_MESCs_Mouse2.05112296
42PHF8_20622854_ChIP-Seq_HELA_Human2.04624671
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.01321910
44CTCF_20526341_ChIP-Seq_ESCs_Human1.97386892
45SMC4_20622854_ChIP-Seq_HELA_Human1.97006846
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95567828
47NANOG_20526341_ChIP-Seq_ESCs_Human1.92619197
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.92060673
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91824822
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91395282
51AR_21909140_ChIP-Seq_LNCAP_Human1.90731819
52TTF2_22483619_ChIP-Seq_HELA_Human1.89655314
53RAC3_21632823_ChIP-Seq_H3396_Human1.85826230
54EZH2_22144423_ChIP-Seq_EOC_Human1.83914702
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.81587518
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81495030
57VDR_23849224_ChIP-Seq_CD4+_Human1.77328587
58EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.76360278
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76009141
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69413582
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68887064
62NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.67863628
63DCP1A_22483619_ChIP-Seq_HELA_Human1.66897654
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.66328597
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64420750
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63977015
67ZNF274_21170338_ChIP-Seq_K562_Hela1.62608282
68P300_27268052_Chip-Seq_Bcells_Human1.62210482
69MYC_19829295_ChIP-Seq_ESCs_Human1.62076142
70GABP_19822575_ChIP-Seq_HepG2_Human1.62043878
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61280091
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.60534973
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.60057477
74TAF2_19829295_ChIP-Seq_ESCs_Human1.60050394
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.59005296
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.58519661
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58143621
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.57633345
79FOXP3_21729870_ChIP-Seq_TREG_Human1.57388614
80TP63_22573176_ChIP-Seq_HFKS_Human1.56607593
81SA1_27219007_Chip-Seq_Bcells_Human1.56395433
82DROSHA_22980978_ChIP-Seq_HELA_Human1.55718430
83FOXP1_21924763_ChIP-Seq_HESCs_Human1.54933430
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.53048833
85OCT4_20526341_ChIP-Seq_ESCs_Human1.52176237
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51113593
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50650333
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47948091
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47764541
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44519726
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44509811
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43600621
93TCF3_18692474_ChIP-Seq_MESCs_Mouse1.41500457
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39135237
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37477823
96P53_21459846_ChIP-Seq_SAOS-2_Human1.36756093
97ERG_20517297_ChIP-Seq_VCAP_Human1.35709648
98WDR5_24793694_ChIP-Seq_LNCAP_Human1.35290609
99SPI1_20517297_ChIP-Seq_HL60_Human1.34633394
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34365266
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33854638
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32672167
103SOX2_22085726_ChIP-Seq_NPCs_Mouse1.32514436
104ELK1_19687146_ChIP-ChIP_HELA_Human1.30240026
105* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.30130615
106SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29724300
107* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.28478490
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.28265500
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27518529
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.27405186
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.26332057
112MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25479643
113P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.25173816
114TDRD3_21172665_ChIP-Seq_MCF-7_Human1.23905842
115CTCF_21964334_Chip-Seq_Bcells_Human1.23681944
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22943559
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22471442
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21198472
119CBP_20019798_ChIP-Seq_JUKART_Human1.21198472
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21116095
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21116095
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20932125
123EZH2_27294783_Chip-Seq_ESCs_Mouse1.19737786
124FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19657399
125RUNX1_26923725_Chip-Seq_HPCs_Mouse1.19545085
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17532308
127SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15815030
128KDM5A_27292631_Chip-Seq_BREAST_Human1.15809229
129RARA_24833708_ChIP-Seq_LIVER_Mouse1.15368409
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14475726
131AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13765600
132HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13540203
133GATA3_21878914_ChIP-Seq_MCF-7_Human1.13073235
134CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12918724
135NANOG_16153702_ChIP-ChIP_HESCs_Human1.12885316
136POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11418840
137* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.09981118
138TP53_20018659_ChIP-ChIP_R1E_Mouse1.09721063
139GATA3_21867929_ChIP-Seq_CD8_Mouse1.08995372
140* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08963105
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07885503
142TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06868823
143NANOG_21062744_ChIP-ChIP_HESCs_Human1.06501767
144CSB_26484114_Chip-Seq_FIBROBLAST_Human1.06189813
145* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.04204591
146* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03747041
147SOX11_22085726_ChIP-Seq_ESNs_Mouse1.03734305
148EZH2_27304074_Chip-Seq_ESCs_Mouse1.03691717
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03552911
150PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03417606
151PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03045447
152ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02791451
153MYC_18940864_ChIP-ChIP_HL60_Human1.02030735
154SALL1_21062744_ChIP-ChIP_HESCs_Human1.01989520
155THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99636152
156* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98793776
157* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.98140827
158JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98047959
159* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97909723
160PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97361761
161OCT4_19829295_ChIP-Seq_ESCs_Human0.96216422
162PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96000933
163EED_16625203_ChIP-ChIP_MESCs_Mouse0.94865210
164SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94614566
165SRF_21415370_ChIP-Seq_HL-1_Mouse0.94451535
166CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94083418
167TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93930247
168EGR1_19374776_ChIP-ChIP_THP-1_Human0.93770996
169DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93008306
170KLF4_19829295_ChIP-Seq_ESCs_Human0.92953589
171PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92714159
172CEBPB_22108803_ChIP-Seq_LS180_Human0.92202728
173SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92048948
174SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90922229
175* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90708729
176SOX2_21211035_ChIP-Seq_LN229_Human0.90679517
177CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90516613
178SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89693935
179NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89680637
180CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89061804
181FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88360140
182E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87647528
183YY1_22570637_ChIP-Seq_MALME-3M_Human0.85870481
184SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85436159
185SOX2_16153702_ChIP-ChIP_HESCs_Human0.84943130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting5.91340787
2MP0003878_abnormal_ear_physiology4.70388241
3MP0005377_hearing/vestibular/ear_phenot4.70388241
4MP0004957_abnormal_blastocyst_morpholog4.09410664
5MP0003693_abnormal_embryo_hatching3.87280323
6MP0003890_abnormal_embryonic-extraembry3.80850559
7MP0010094_abnormal_chromosome_stability3.17325931
8MP0004133_heterotaxia3.17268323
9MP0003077_abnormal_cell_cycle3.17047314
10MP0003121_genomic_imprinting3.17011114
11MP0008057_abnormal_DNA_replication3.16341180
12MP0003111_abnormal_nucleus_morphology3.03976644
13MP0001348_abnormal_lacrimal_gland2.73143299
14MP0010030_abnormal_orbit_morphology2.71853588
15MP0008932_abnormal_embryonic_tissue2.69483419
16MP0001730_embryonic_growth_arrest2.68454539
17MP0008058_abnormal_DNA_repair2.59680710
18MP0002653_abnormal_ependyma_morphology2.52813580
19MP0006292_abnormal_olfactory_placode2.46614780
20MP0002822_catalepsy2.44782970
21MP0008877_abnormal_DNA_methylation2.36105777
22MP0008007_abnormal_cellular_replicative2.30993763
23MP0010368_abnormal_lymphatic_system2.27108513
24MP0003806_abnormal_nucleotide_metabolis2.25097590
25MP0010352_gastrointestinal_tract_polyps2.19259980
26MP0003119_abnormal_digestive_system2.08821207
27* MP0005380_embryogenesis_phenotype2.08078025
28* MP0001672_abnormal_embryogenesis/_devel2.08078025
29MP0005379_endocrine/exocrine_gland_phen1.96702799
30MP0005248_abnormal_Harderian_gland1.96395064
31MP0003646_muscle_fatigue1.95354699
32MP0002084_abnormal_developmental_patter1.93361723
33MP0003122_maternal_imprinting1.90486185
34MP0003011_delayed_dark_adaptation1.85196033
35* MP0001697_abnormal_embryo_size1.83814279
36* MP0003984_embryonic_growth_retardation1.82399156
37* MP0002088_abnormal_embryonic_growth/wei1.81086317
38* MP0002085_abnormal_embryonic_tissue1.79533948
39MP0000350_abnormal_cell_proliferation1.75971346
40MP0003567_abnormal_fetal_cardiomyocyte1.72174574
41MP0001879_abnormal_lymphatic_vessel1.66680608
42MP0001293_anophthalmia1.65860200
43MP0000537_abnormal_urethra_morphology1.62718592
44MP0005410_abnormal_fertilization1.61134107
45MP0003315_abnormal_perineum_morphology1.58287030
46MP0004197_abnormal_fetal_growth/weight/1.54361033
47* MP0002086_abnormal_extraembryonic_tissu1.53511071
48MP0002132_abnormal_respiratory_system1.47771458
49* MP0002080_prenatal_lethality1.46269127
50MP0005646_abnormal_pituitary_gland1.45801804
51MP0003937_abnormal_limbs/digits/tail_de1.45703216
52MP0009379_abnormal_foot_pigmentation1.44610678
53MP0002282_abnormal_trachea_morphology1.41488878
54MP0001968_abnormal_touch/_nociception1.34958238
55MP0000678_abnormal_parathyroid_gland1.34839407
56MP0002234_abnormal_pharynx_morphology1.29109643
57MP0002111_abnormal_tail_morphology1.27715565
58MP0000534_abnormal_ureter_morphology1.25255093
59MP0000049_abnormal_middle_ear1.24937405
60MP0005423_abnormal_somatic_nervous1.24806253
61MP0003718_maternal_effect1.22724517
62MP0009053_abnormal_anal_canal1.22473253
63MP0002210_abnormal_sex_determination1.17912192
64MP0003786_premature_aging1.17383815
65MP0000026_abnormal_inner_ear1.16023650
66MP0002102_abnormal_ear_morphology1.09916043
67MP0003938_abnormal_ear_development1.09403750
68MP0001485_abnormal_pinna_reflex1.08606100
69MP0005451_abnormal_body_composition1.07917760
70MP0002127_abnormal_cardiovascular_syste1.06883728
71MP0001929_abnormal_gametogenesis1.06371410
72MP0001145_abnormal_male_reproductive1.06112579
73* MP0000313_abnormal_cell_death1.01521118
74MP0003705_abnormal_hypodermis_morpholog0.99611321
75MP0005253_abnormal_eye_physiology0.98794422
76MP0003186_abnormal_redox_activity0.97802577
77MP0000516_abnormal_urinary_system0.97647673
78MP0005367_renal/urinary_system_phenotyp0.97647673
79MP0000428_abnormal_craniofacial_morphol0.97501152
80MP0003385_abnormal_body_wall0.97474705
81MP0005551_abnormal_eye_electrophysiolog0.97455706
82MP0002932_abnormal_joint_morphology0.97399003
83MP0002160_abnormal_reproductive_system0.97274412
84MP0003935_abnormal_craniofacial_develop0.95286201
85MP0000432_abnormal_head_morphology0.94997651
86MP0010307_abnormal_tumor_latency0.94426928
87MP0000566_synostosis0.94076511
88MP0002733_abnormal_thermal_nociception0.92531074
89MP0001905_abnormal_dopamine_level0.91600968
90MP0005391_vision/eye_phenotype0.91397223
91MP0003698_abnormal_male_reproductive0.90367829
92MP0003861_abnormal_nervous_system0.89878380
93MP0001727_abnormal_embryo_implantation0.88895323
94MP0009672_abnormal_birth_weight0.87994354
95MP0005623_abnormal_meninges_morphology0.87044558
96MP0004742_abnormal_vestibular_system0.86157365
97MP0001963_abnormal_hearing_physiology0.85622630
98MP0005083_abnormal_biliary_tract0.84583642
99MP0000372_irregular_coat_pigmentation0.83970661
100MP0000653_abnormal_sex_gland0.83715312
101MP0005670_abnormal_white_adipose0.83072959
102MP0002735_abnormal_chemical_nociception0.82307336
103MP0006072_abnormal_retinal_apoptosis0.81531727
104MP0003941_abnormal_skin_development0.81527901
105MP0001346_abnormal_lacrimal_gland0.81475314
106MP0000681_abnormal_thyroid_gland0.81416058
107MP0003566_abnormal_cell_adhesion0.81203920
108MP0005266_abnormal_metabolism0.80734298
109MP0002249_abnormal_larynx_morphology0.79959549
110MP0005499_abnormal_olfactory_system0.79089476
111MP0005394_taste/olfaction_phenotype0.79089476
112MP0002138_abnormal_hepatobiliary_system0.79063783
113MP0001849_ear_inflammation0.77472940
114MP0002557_abnormal_social/conspecific_i0.75039736
115* MP0002925_abnormal_cardiovascular_devel0.74806102
116MP0005645_abnormal_hypothalamus_physiol0.73851253
117MP0001286_abnormal_eye_development0.73435043
118MP0003942_abnormal_urinary_system0.73075282
119MP0005408_hypopigmentation0.72992749
120MP0002736_abnormal_nociception_after0.72989519
121MP0000358_abnormal_cell_content/0.72737937
122MP0000955_abnormal_spinal_cord0.71944173
123MP0003755_abnormal_palate_morphology0.71669120
124MP0001764_abnormal_homeostasis0.70756921
125MP0005395_other_phenotype0.70568489
126MP0002114_abnormal_axial_skeleton0.70348686
127MP0000003_abnormal_adipose_tissue0.69197013
128MP0004264_abnormal_extraembryonic_tissu0.68726687
129MP0001765_abnormal_ion_homeostasis0.68175526
130MP0002938_white_spotting0.68035244
131MP0000762_abnormal_tongue_morphology0.67851078
132MP0002092_abnormal_eye_morphology0.67779456
133MP0002163_abnormal_gland_morphology0.67625368
134MP0002019_abnormal_tumor_incidence0.67366961
135MP0000750_abnormal_muscle_regeneration0.67185516
136MP0005384_cellular_phenotype0.66776598
137MP0008995_early_reproductive_senescence0.66363483
138MP0003283_abnormal_digestive_organ0.66150823
139MP0000013_abnormal_adipose_tissue0.65387090
140MP0002229_neurodegeneration0.64250385
141MP0008789_abnormal_olfactory_epithelium0.64226826
142MP0005023_abnormal_wound_healing0.63840600
143MP0005389_reproductive_system_phenotype0.63629195
144MP0001915_intracranial_hemorrhage0.63416513
145MP0006035_abnormal_mitochondrial_morpho0.62349515
146MP0002161_abnormal_fertility/fecundity0.62281190
147MP0003879_abnormal_hair_cell0.62089288
148MP0009278_abnormal_bone_marrow0.58270487
149MP0001486_abnormal_startle_reflex0.57648094
150MP0003136_yellow_coat_color0.55044991
151MP0005195_abnormal_posterior_eye0.54218494
152MP0005084_abnormal_gallbladder_morpholo0.53583136
153MP0001970_abnormal_pain_threshold0.51385876
154MP0005636_abnormal_mineral_homeostasis0.49258685
155MP0009046_muscle_twitch0.48297014
156MP0003137_abnormal_impulse_conducting0.47964669
157MP0000631_abnormal_neuroendocrine_gland0.47490288
158MP0006276_abnormal_autonomic_nervous0.47423094
159MP0004510_myositis0.46998750
160MP0009697_abnormal_copulation0.46302941
161MP0002697_abnormal_eye_size0.45744106
162MP0003959_abnormal_lean_body0.45166650
163MP0008569_lethality_at_weaning0.44902394
164MP0005310_abnormal_salivary_gland0.44773149

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)6.97558044
2Chronic hepatic failure (HP:0100626)4.68025408
3Bony spicule pigmentary retinopathy (HP:0007737)4.63400237
4Attenuation of retinal blood vessels (HP:0007843)4.57835116
5Absent/shortened dynein arms (HP:0200106)4.43828436
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.43828436
7Renal Fanconi syndrome (HP:0001994)4.17959989
8Abnormal rod and cone electroretinograms (HP:0008323)3.98085535
9Male infertility (HP:0003251)3.90058354
10Birth length less than 3rd percentile (HP:0003561)3.87414418
11Breast hypoplasia (HP:0003187)3.83718997
12Colon cancer (HP:0003003)3.82698878
13Selective tooth agenesis (HP:0001592)3.77651095
14Abnormal ciliary motility (HP:0012262)3.75382862
15Enlarged epiphyses (HP:0010580)3.71819245
16Abdominal situs inversus (HP:0003363)3.70740023
17Abnormality of abdominal situs (HP:0011620)3.70740023
18Reticulocytopenia (HP:0001896)3.67692413
19Infertility (HP:0000789)3.61153152
20Abnormal respiratory motile cilium physiology (HP:0012261)3.53140225
21Aplasia/Hypoplasia of the earlobes (HP:0009906)3.49261789
22Carpal bone hypoplasia (HP:0001498)3.47002374
23Hyperthyroidism (HP:0000836)3.44498575
24Bell-shaped thorax (HP:0001591)3.39273526
25Generalized aminoaciduria (HP:0002909)3.38102765
26Supernumerary spleens (HP:0009799)3.37990225
27Abnormality of macular pigmentation (HP:0008002)3.33724688
28Rib fusion (HP:0000902)3.28985293
29Asymmetric septal hypertrophy (HP:0001670)3.28632399
30Absent radius (HP:0003974)3.24060799
31Abnormal umbilical cord blood vessels (HP:0011403)3.22830828
32Single umbilical artery (HP:0001195)3.22830828
33Abnormality of the fetal cardiovascular system (HP:0010948)3.22830828
34Aplasia/hypoplasia of the humerus (HP:0006507)3.19537998
35Congenital malformation of the right heart (HP:0011723)3.16872610
36Double outlet right ventricle (HP:0001719)3.16872610
37Abnormal respiratory motile cilium morphology (HP:0005938)3.13926128
38Abnormal respiratory epithelium morphology (HP:0012253)3.13926128
39Ependymoma (HP:0002888)3.10901299
40Sclerocornea (HP:0000647)3.10744955
41Transposition of the great arteries (HP:0001669)3.06613784
42Abnormal connection of the cardiac segments (HP:0011545)3.06613784
43Abnormal ventriculo-arterial connection (HP:0011563)3.06613784
44Occipital encephalocele (HP:0002085)3.05242278
45Abnormal lung lobation (HP:0002101)3.04859501
46Aplasia involving forearm bones (HP:0009822)3.02018173
47Absent forearm bone (HP:0003953)3.02018173
48Multiple enchondromatosis (HP:0005701)2.99931079
49Medulloblastoma (HP:0002885)2.98998878
50Nephronophthisis (HP:0000090)2.94569629
51Macrocytic anemia (HP:0001972)2.91695586
52Nasal polyposis (HP:0100582)2.90068800
53Pancreatic fibrosis (HP:0100732)2.88353193
54Abnormality of cells of the erythroid lineage (HP:0012130)2.88009691
55Impulsivity (HP:0100710)2.85016437
56Glycosuria (HP:0003076)2.79998295
57Abnormality of urine glucose concentration (HP:0011016)2.79998295
58Abnormal urine output (HP:0012590)2.76902368
59Breast aplasia (HP:0100783)2.76744373
60Patellar aplasia (HP:0006443)2.75941523
61True hermaphroditism (HP:0010459)2.74683494
62Abnormality of the costochondral junction (HP:0000919)2.72873100
63Hyperkalemia (HP:0002153)2.72763111
64Unilateral renal agenesis (HP:0000122)2.71940136
65Facial cleft (HP:0002006)2.69201173
66Oral leukoplakia (HP:0002745)2.67849831
67Renal dysplasia (HP:0000110)2.66287368
68Trismus (HP:0000211)2.66031522
69Fused cervical vertebrae (HP:0002949)2.65072913
70Rectal fistula (HP:0100590)2.63762906
71Rectovaginal fistula (HP:0000143)2.63762906
72Hypophosphatemic rickets (HP:0004912)2.62742714
73Abnormal spermatogenesis (HP:0008669)2.62284678
74Abnormality of renal resorption (HP:0011038)2.62249588
75Abnormal drinking behavior (HP:0030082)2.61239346
76Polydipsia (HP:0001959)2.61239346
77Abnormal number of incisors (HP:0011064)2.57951453
78Short humerus (HP:0005792)2.57457298
79Cerebral hypomyelination (HP:0006808)2.57347119
80Polyuria (HP:0000103)2.57298976
81Aplasia/Hypoplasia of the patella (HP:0006498)2.56902806
82Meckel diverticulum (HP:0002245)2.56191757
83Aplasia/Hypoplasia of the breasts (HP:0010311)2.53367795
84Azoospermia (HP:0000027)2.49788606
85Abnormality of the nasal mucosa (HP:0000433)2.49574380
86Hypoplasia of the thymus (HP:0000778)2.47694306
87Resting tremor (HP:0002322)2.46510064
88Abnormality of the ileum (HP:0001549)2.44533651
89Rough bone trabeculation (HP:0100670)2.44116234
90Nephroblastoma (Wilms tumor) (HP:0002667)2.42795896
91Abnormal number of erythroid precursors (HP:0012131)2.40984800
92Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.40703575
93Portal hypertension (HP:0001409)2.39737952
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.37471870
95Asplenia (HP:0001746)2.36283757
96Aplasia/Hypoplasia of the sacrum (HP:0008517)2.36207233
97Potter facies (HP:0002009)2.36080538
98Facial shape deformation (HP:0011334)2.36080538
99Atresia of the external auditory canal (HP:0000413)2.35261537
100Preauricular skin tag (HP:0000384)2.34391243
101Abnormality of the labia minora (HP:0012880)2.34368941
102Embryonal renal neoplasm (HP:0011794)2.33640062
103Abnormality of the hepatic vasculature (HP:0006707)2.32789013
104Amelogenesis imperfecta (HP:0000705)2.32721589
105Sensory axonal neuropathy (HP:0003390)2.31603687
106Rhabdomyosarcoma (HP:0002859)2.30651173
107Degeneration of anterior horn cells (HP:0002398)2.30184737
108Abnormality of the anterior horn cell (HP:0006802)2.30184737
109Microretrognathia (HP:0000308)2.29454250
110Abnormality of the parathyroid morphology (HP:0011766)2.29368557
111Progressive external ophthalmoplegia (HP:0000590)2.29205692
112Missing ribs (HP:0000921)2.28580041
113Hypoplastic ischia (HP:0003175)2.26474446
114Absent thumb (HP:0009777)2.25891434
115Abnormality of renal excretion (HP:0011036)2.24500946
116Intestinal fistula (HP:0100819)2.24383065
117Atelectasis (HP:0100750)2.23888865
118Pendular nystagmus (HP:0012043)2.22848131
119Cleft eyelid (HP:0000625)2.22366267
120Decreased central vision (HP:0007663)2.22221606
121Delayed epiphyseal ossification (HP:0002663)2.21705239
122Hypoplastic left heart (HP:0004383)2.21207068
123Pancreatic cysts (HP:0001737)2.20731989
124Abnormality of the renal medulla (HP:0100957)2.20214017
125Seborrheic dermatitis (HP:0001051)2.19938783
126Truncus arteriosus (HP:0001660)2.19657750
127Vaginal fistula (HP:0004320)2.19350113
128Aplasia/Hypoplasia of the spleen (HP:0010451)2.18811782
129Partial duplication of the phalanx of hand (HP:0009999)2.18286341
130Widely patent fontanelles and sutures (HP:0004492)2.17515569
131Partial duplication of thumb phalanx (HP:0009944)2.17467715
132Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16128042
133Triphalangeal thumb (HP:0001199)2.15636092
134Stenosis of the external auditory canal (HP:0000402)2.15461546
135Skin tags (HP:0010609)2.15089365
136Pallor (HP:0000980)2.15055615
137Lipid accumulation in hepatocytes (HP:0006561)2.14679697
138Abnormality of the aortic arch (HP:0012303)2.13502501
139Vertebral fusion (HP:0002948)2.13366408
140Hypoplastic heart (HP:0001961)2.10454264
141Hypoparathyroidism (HP:0000829)2.09726077
142Chromsome breakage (HP:0040012)2.08451655
143Abnormality of dental color (HP:0011073)2.08294914
144Horseshoe kidney (HP:0000085)2.07474355
145Tubulointerstitial nephritis (HP:0001970)2.06848008
146Stage 5 chronic kidney disease (HP:0003774)2.05938449
147Hyperphosphaturia (HP:0003109)2.04761819
148Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03623953
149Short 4th metacarpal (HP:0010044)2.03623953
150Tongue fasciculations (HP:0001308)2.01611132
151Intellectual disability, moderate (HP:0002342)2.01285665
152Hypertensive crisis (HP:0100735)2.01088494
153Supernumerary bones of the axial skeleton (HP:0009144)2.00467031
154Neoplasm of striated muscle (HP:0009728)1.99792326
155Cone-rod dystrophy (HP:0000548)1.99248758
156Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98918723
157Hyponatremia (HP:0002902)1.98751644
158Proximal placement of thumb (HP:0009623)1.98240433
159Tracheoesophageal fistula (HP:0002575)1.98166402
160Deviation of the thumb (HP:0009603)1.97626309
161Shawl scrotum (HP:0000049)1.97576896
162Diastasis recti (HP:0001540)1.97017451
163Thin bony cortex (HP:0002753)1.96870416
164Increased hepatocellular lipid droplets (HP:0006565)1.96747759
165Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95854051
166Preaxial foot polydactyly (HP:0001841)1.95439344
167Neoplasm of the pancreas (HP:0002894)1.95201501
168Renovascular hypertension (HP:0100817)1.95151541
169Hemivertebrae (HP:0002937)1.94986436
170Progressive cerebellar ataxia (HP:0002073)1.94698651
171Abnormality of the astrocytes (HP:0100707)1.94429843
172Astrocytoma (HP:0009592)1.94429843
173Testicular atrophy (HP:0000029)1.94126139
174Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93850196
175Chronic bronchitis (HP:0004469)1.93805254
176Exertional dyspnea (HP:0002875)1.93791551
177Anencephaly (HP:0002323)1.92903984
178Tetany (HP:0001281)1.92886810
179Abnormality of the umbilical cord (HP:0010881)1.92782916
180Glossoptosis (HP:0000162)1.92760817
181Muscle fiber atrophy (HP:0100295)1.92751707
182Cerebellar dysplasia (HP:0007033)1.92087553
183Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.91528907
184Absent epiphyses (HP:0010577)1.91528907
185Abnormality of the lower motor neuron (HP:0002366)1.89226116
186Osteomalacia (HP:0002749)1.88242607
187Progressive sensorineural hearing impairment (HP:0000408)1.87946702
188Renal duplication (HP:0000075)1.87440246
189Myokymia (HP:0002411)1.87054762
190Ectopic kidney (HP:0000086)1.86825406
191Premature ovarian failure (HP:0008209)1.86570935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.99964647
2MAP4K24.43328135
3WEE14.08949277
4TIE14.03908082
5CDC73.87819185
6PLK43.80869209
7DDR23.46422549
8EIF2AK13.03639617
9MAPK152.94548761
10TTK2.85620267
11LATS22.69052604
12NEK12.54078036
13SRPK12.43214250
14NEK22.35235752
15TSSK62.34219279
16VRK22.29072926
17INSRR2.27060462
18STK382.26936494
19TAF12.11153050
20CDK122.02335318
21NME21.93651766
22PLK11.89922977
23STK38L1.85488770
24ZAK1.85068510
25TESK11.84609339
26CDK71.81387479
27CAMK1G1.75434896
28TRIM281.69898934
29ACVR1B1.69657799
30PASK1.64595982
31VRK11.58416690
32PLK21.55065764
33STK101.54904812
34MAP3K81.53430046
35PLK31.49242829
36TGFBR11.46982725
37EIF2AK31.46562196
38EPHA21.46267581
39DYRK1B1.40455530
40CHEK21.39573272
41AURKB1.36606606
42AKT31.36568796
43CHEK11.36182044
44TESK21.34066346
45AURKA1.31833869
46MKNK11.27048069
47RPS6KB21.25270056
48ATR1.24823539
49BRSK21.23150876
50DYRK21.21697676
51PAK41.21195702
52KDR1.19745873
53CAMK1D1.17691177
54BRSK11.14224822
55PDPK11.08246122
56MAP2K71.07754512
57PRKD31.07231571
58DYRK31.05249458
59SMG11.03080610
60PAK10.95096382
61EPHB20.94611480
62PDK30.92107247
63PDK40.92107247
64NME10.92089406
65TAOK30.91229470
66BRAF0.90018168
67BCKDK0.89803787
68PDK10.88816850
69TLK10.87675723
70CDK20.85886805
71WNK10.82576610
72STK160.79111225
73CSNK2A20.78586870
74ATM0.78428308
75MAP3K110.75566063
76EIF2AK20.75180024
77STK240.74447935
78PBK0.74018409
79ALK0.73680353
80LRRK20.73116313
81CDK80.72881349
82PTK2B0.72793069
83ABL20.71752005
84MET0.69794511
85CSNK2A10.68868507
86CDK40.67145778
87PINK10.66418213
88PNCK0.66279593
89CLK10.64799593
90ERN10.64220792
91CSNK1E0.64165971
92CDK10.63869474
93BMPR1B0.63101471
94RPS6KA20.61926616
95MAP2K20.60216503
96MAP2K40.60132363
97PDK20.58133395
98MST1R0.56066437
99ICK0.55909561
100STK30.55732831
101MAP3K40.54995916
102RPS6KC10.54959320
103RPS6KL10.54959320
104STK40.51982586
105RPS6KA60.51763621
106WNK40.51209160
107SCYL20.49055082
108GRK60.48908021
109CDK190.48126315
110PIK3CG0.47281355
111YES10.46988773
112BRD40.45534529
113PRKAA20.44641909
114PRKG20.44305889
115MELK0.44270456
116PKN20.43629504
117ILK0.43484951
118AKT20.42677943
119RPS6KA10.42665108
120CAMK10.42061604
121PRKCI0.41991895
122STK390.41966199
123GRK50.41534471
124MAP3K30.40797129
125FGFR10.38997471
126CDK11A0.38419775
127CDK150.37364722
128MTOR0.37223849
129MAP4K10.36700945
130RPS6KA40.36519965
131CDK140.36271200
132MKNK20.35954874
133CSNK1G30.35177018
134NUAK10.34980720
135RPS6KA50.34080069
136CDK180.34070198
137LIMK10.33430435
138FLT30.32603391
139PIM10.32102254
140PRKDC0.31829974
141TEC0.31483894
142MAP3K10.30305932
143GSK3B0.27823774
144CDK60.27069185
145WNK30.26533370
146CSNK1G20.24968305
147CAMK40.24078646
148PAK20.23981991
149TNK20.22839208
150TRIB30.22492817
151PRKG10.22451475
152DAPK10.22327142
153MAP2K30.22162077
154GRK10.22115760
155CSNK1A1L0.21298334
156MAPK80.21128369
157SIK20.20749058
158CAMKK20.20684241
159ADRBK20.19848314
160AKT10.18928420
161RIPK10.18692143
162MAPK110.18180588
163PIM20.17185156
164MAPK10.17005628
165HIPK20.16860670
166GRK70.16446410
167PRKCB0.15668054

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.88727602
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.53357823
3Ribosome_Homo sapiens_hsa030104.53617876
4DNA replication_Homo sapiens_hsa030304.44585513
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.12269127
6Mismatch repair_Homo sapiens_hsa034303.87594104
7RNA polymerase_Homo sapiens_hsa030203.76632501
8Spliceosome_Homo sapiens_hsa030403.64274007
9Proteasome_Homo sapiens_hsa030503.55984446
10RNA transport_Homo sapiens_hsa030133.23340471
11One carbon pool by folate_Homo sapiens_hsa006703.11566787
12Pyrimidine metabolism_Homo sapiens_hsa002402.74500080
13Homologous recombination_Homo sapiens_hsa034402.74340532
14Base excision repair_Homo sapiens_hsa034102.45717370
15Nucleotide excision repair_Homo sapiens_hsa034202.41714390
16Olfactory transduction_Homo sapiens_hsa047402.40876903
17Cell cycle_Homo sapiens_hsa041102.34813537
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31027715
19Butanoate metabolism_Homo sapiens_hsa006502.30467763
20Fatty acid metabolism_Homo sapiens_hsa012122.04937079
21RNA degradation_Homo sapiens_hsa030181.94310870
22Basal transcription factors_Homo sapiens_hsa030221.92610569
23Fanconi anemia pathway_Homo sapiens_hsa034601.92198566
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.84655559
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.75145979
26Non-homologous end-joining_Homo sapiens_hsa034501.74292473
27mRNA surveillance pathway_Homo sapiens_hsa030151.63409161
28Fatty acid degradation_Homo sapiens_hsa000711.50839947
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.49689883
30Biosynthesis of amino acids_Homo sapiens_hsa012301.47768589
31Purine metabolism_Homo sapiens_hsa002301.47478786
32Phototransduction_Homo sapiens_hsa047441.34423690
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.28824150
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.25441868
35p53 signaling pathway_Homo sapiens_hsa041151.22752871
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20299366
37Oocyte meiosis_Homo sapiens_hsa041141.18077934
38Basal cell carcinoma_Homo sapiens_hsa052171.17000242
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15236734
40Huntingtons disease_Homo sapiens_hsa050161.12622571
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09514072
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09296362
43Pentose phosphate pathway_Homo sapiens_hsa000301.04298883
44Epstein-Barr virus infection_Homo sapiens_hsa051691.03218062
45Hippo signaling pathway_Homo sapiens_hsa043900.99726086
46Taste transduction_Homo sapiens_hsa047420.99172358
47Folate biosynthesis_Homo sapiens_hsa007900.96659521
48Glutathione metabolism_Homo sapiens_hsa004800.96457064
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96225255
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93000590
51Hedgehog signaling pathway_Homo sapiens_hsa043400.92852643
52Carbon metabolism_Homo sapiens_hsa012000.90956703
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90587736
54Parkinsons disease_Homo sapiens_hsa050120.88916628
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82876499
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.82852717
57Type II diabetes mellitus_Homo sapiens_hsa049300.81067705
58TGF-beta signaling pathway_Homo sapiens_hsa043500.80193863
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.78909653
60Systemic lupus erythematosus_Homo sapiens_hsa053220.77842475
61Oxidative phosphorylation_Homo sapiens_hsa001900.77819261
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76981082
63Peroxisome_Homo sapiens_hsa041460.76374637
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76090089
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73197289
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.71926470
67Nicotine addiction_Homo sapiens_hsa050330.71752136
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71132221
69Selenocompound metabolism_Homo sapiens_hsa004500.66290961
70Vitamin B6 metabolism_Homo sapiens_hsa007500.66020779
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.63993666
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63371640
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63161905
74Phenylalanine metabolism_Homo sapiens_hsa003600.59368288
75Regulation of autophagy_Homo sapiens_hsa041400.58888166
76Endocytosis_Homo sapiens_hsa041440.57921752
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56917240
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56531507
79Fructose and mannose metabolism_Homo sapiens_hsa000510.53487636
80Synaptic vesicle cycle_Homo sapiens_hsa047210.53054446
81Thyroid cancer_Homo sapiens_hsa052160.52980267
82Arachidonic acid metabolism_Homo sapiens_hsa005900.52197713
83Morphine addiction_Homo sapiens_hsa050320.51941958
84Linoleic acid metabolism_Homo sapiens_hsa005910.51489603
85Pyruvate metabolism_Homo sapiens_hsa006200.50980014
86Viral carcinogenesis_Homo sapiens_hsa052030.50951933
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50858662
88N-Glycan biosynthesis_Homo sapiens_hsa005100.50190181
89Arginine and proline metabolism_Homo sapiens_hsa003300.48871536
90Adherens junction_Homo sapiens_hsa045200.48311714
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47290127
92HTLV-I infection_Homo sapiens_hsa051660.46710572
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46318860
94Protein digestion and absorption_Homo sapiens_hsa049740.45804675
95MicroRNAs in cancer_Homo sapiens_hsa052060.43220561
96Tight junction_Homo sapiens_hsa045300.42623949
97Wnt signaling pathway_Homo sapiens_hsa043100.41556719
98VEGF signaling pathway_Homo sapiens_hsa043700.40658085
99Inositol phosphate metabolism_Homo sapiens_hsa005620.40536598
100PPAR signaling pathway_Homo sapiens_hsa033200.40499656
101Insulin secretion_Homo sapiens_hsa049110.40369481
102ABC transporters_Homo sapiens_hsa020100.39722168
103Sulfur relay system_Homo sapiens_hsa041220.37723880
104Tyrosine metabolism_Homo sapiens_hsa003500.36505919
105Metabolic pathways_Homo sapiens_hsa011000.35639479
106Glycerolipid metabolism_Homo sapiens_hsa005610.35336976
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34979677
108Melanoma_Homo sapiens_hsa052180.33220682
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31932721
110Pathways in cancer_Homo sapiens_hsa052000.31302738
111Protein export_Homo sapiens_hsa030600.30486769
112Type I diabetes mellitus_Homo sapiens_hsa049400.29919141
113Fat digestion and absorption_Homo sapiens_hsa049750.29309454
114Herpes simplex infection_Homo sapiens_hsa051680.29188417
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29128159
116Alzheimers disease_Homo sapiens_hsa050100.28816990
117Cardiac muscle contraction_Homo sapiens_hsa042600.26169587
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25303577
119Calcium signaling pathway_Homo sapiens_hsa040200.23059052
120Salivary secretion_Homo sapiens_hsa049700.22275665
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.22135763
122mTOR signaling pathway_Homo sapiens_hsa041500.21632195
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20828370
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20824615
125HIF-1 signaling pathway_Homo sapiens_hsa040660.19645902
126Antigen processing and presentation_Homo sapiens_hsa046120.19482745
127Arginine biosynthesis_Homo sapiens_hsa002200.19092984
128Alcoholism_Homo sapiens_hsa050340.18263673
129Renin-angiotensin system_Homo sapiens_hsa046140.17904329
130Bladder cancer_Homo sapiens_hsa052190.17711241
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16670853
132Propanoate metabolism_Homo sapiens_hsa006400.15810293
133GABAergic synapse_Homo sapiens_hsa047270.15765461
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15272629
135Galactose metabolism_Homo sapiens_hsa000520.13478820
136Sphingolipid metabolism_Homo sapiens_hsa006000.12448749
137Lysine degradation_Homo sapiens_hsa003100.11591313
138Small cell lung cancer_Homo sapiens_hsa052220.11082044
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.10734635
140Retinol metabolism_Homo sapiens_hsa008300.09125672
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08549693
142Notch signaling pathway_Homo sapiens_hsa043300.08454439
143Steroid biosynthesis_Homo sapiens_hsa001000.07763193
144Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06421926
145Chemical carcinogenesis_Homo sapiens_hsa052040.03945921

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