

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NIK/NF-kappaB signaling (GO:0038061) | 8.75975963 |
| 2 | regulation of vitamin D biosynthetic process (GO:0060556) | 5.89668340 |
| 3 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.10662772 |
| 4 | response to muramyl dipeptide (GO:0032495) | 5.05778457 |
| 5 | natural killer cell mediated cytotoxicity (GO:0042267) | 4.95978221 |
| 6 | natural killer cell mediated immunity (GO:0002228) | 4.95978221 |
| 7 | branching involved in labyrinthine layer morphogenesis (GO:0060670) | 4.91446656 |
| 8 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 4.90757014 |
| 9 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.84308011 |
| 10 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 4.81557059 |
| 11 | myeloid dendritic cell differentiation (GO:0043011) | 4.67026641 |
| 12 | regulation of vitamin metabolic process (GO:0030656) | 4.56040976 |
| 13 | regulation of RIG-I signaling pathway (GO:0039535) | 4.50403955 |
| 14 | neutrophil activation involved in immune response (GO:0002283) | 4.48707912 |
| 15 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.47866663 |
| 16 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.47866663 |
| 17 | negative regulation of interleukin-12 production (GO:0032695) | 4.46722051 |
| 18 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.42869721 |
| 19 | positive regulation of antigen processing and presentation (GO:0002579) | 4.33146117 |
| 20 | growth hormone receptor signaling pathway (GO:0060396) | 4.28413644 |
| 21 | neutrophil activation (GO:0042119) | 4.27754308 |
| 22 | myeloid dendritic cell activation (GO:0001773) | 4.26747879 |
| 23 | positive regulation of heat generation (GO:0031652) | 4.11847403 |
| 24 | regulation of fever generation (GO:0031620) | 4.10444541 |
| 25 | granulocyte activation (GO:0036230) | 4.09784483 |
| 26 | T-helper cell differentiation (GO:0042093) | 4.04089825 |
| 27 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 4.04089825 |
| 28 | regulation of necroptotic process (GO:0060544) | 4.02989253 |
| 29 | positive regulation of natural killer cell differentiation (GO:0032825) | 4.01005477 |
| 30 | dendritic cell differentiation (GO:0097028) | 3.92513761 |
| 31 | positive regulation of chemokine biosynthetic process (GO:0045080) | 3.88606976 |
| 32 | regulation of antigen processing and presentation (GO:0002577) | 3.87455515 |
| 33 | negative thymic T cell selection (GO:0045060) | 3.83744237 |
| 34 | regulation of chronic inflammatory response (GO:0002676) | 3.78725240 |
| 35 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.78238625 |
| 36 | T cell differentiation involved in immune response (GO:0002292) | 3.73749692 |
| 37 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 3.73749692 |
| 38 | alpha-beta T cell activation involved in immune response (GO:0002287) | 3.73749692 |
| 39 | regulation of podosome assembly (GO:0071801) | 3.69952166 |
| 40 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531) | 3.64607202 |
| 41 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 3.63217820 |
| 42 | cellular response to growth hormone stimulus (GO:0071378) | 3.63137920 |
| 43 | negative T cell selection (GO:0043383) | 3.62594174 |
| 44 | positive regulation of interleukin-12 production (GO:0032735) | 3.61398868 |
| 45 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.59311241 |
| 46 | negative regulation of necroptotic process (GO:0060546) | 3.56451025 |
| 47 | interferon-gamma secretion (GO:0072643) | 3.52088724 |
| 48 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 3.51899634 |
| 49 | regulation of chemokine biosynthetic process (GO:0045073) | 3.51863200 |
| 50 | regulation of T-helper 1 cell differentiation (GO:0045625) | 3.45415635 |
| 51 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 3.44316878 |
| 52 | regulation of cytokine secretion involved in immune response (GO:0002739) | 3.41334724 |
| 53 | negative regulation of toll-like receptor 4 signaling pathway (GO:0034144) | 3.39197196 |
| 54 | regulation of T cell tolerance induction (GO:0002664) | 3.37933195 |
| 55 | regulation of MHC class I biosynthetic process (GO:0045343) | 3.37062889 |
| 56 | positive regulation of interleukin-2 production (GO:0032743) | 3.35332993 |
| 57 | mature B cell differentiation (GO:0002335) | 3.31600310 |
| 58 | immunoglobulin mediated immune response (GO:0016064) | 3.29659568 |
| 59 | regulation of membrane protein ectodomain proteolysis (GO:0051043) | 3.28805823 |
| 60 | regulation of gamma-delta T cell activation (GO:0046643) | 3.28621326 |
| 61 | positive regulation of NF-kappaB import into nucleus (GO:0042346) | 3.28392865 |
| 62 | positive regulation of interferon-alpha production (GO:0032727) | 3.27670514 |
| 63 | response to protozoan (GO:0001562) | 3.24888628 |
| 64 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 3.24392835 |
| 65 | positive regulation of humoral immune response (GO:0002922) | 3.24016347 |
| 66 | positive regulation of T cell cytokine production (GO:0002726) | 3.23465219 |
| 67 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.19554111 |
| 68 | negative regulation of cell killing (GO:0031342) | 3.18154197 |
| 69 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.18154197 |
| 70 | positive regulation of B cell differentiation (GO:0045579) | 3.16497291 |
| 71 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.15423603 |
| 72 | T cell activation involved in immune response (GO:0002286) | 3.15244467 |
| 73 | response to type I interferon (GO:0034340) | 3.14909285 |
| 74 | regulation of hypersensitivity (GO:0002883) | 3.14197821 |
| 75 | defense response to protozoan (GO:0042832) | 3.14169659 |
| 76 | type I interferon signaling pathway (GO:0060337) | 3.14100385 |
| 77 | cellular response to type I interferon (GO:0071357) | 3.14100385 |
| 78 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.13774338 |
| 79 | regulation of T-helper cell differentiation (GO:0045622) | 3.13750193 |
| 80 | regulation of heat generation (GO:0031650) | 3.13262428 |
| 81 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 3.12955597 |
| 82 | necroptotic process (GO:0070266) | 3.10741192 |
| 83 | regulation of interferon-alpha production (GO:0032647) | 3.10615051 |
| 84 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.10563892 |
| 85 | response to peptidoglycan (GO:0032494) | 3.10111991 |
| 86 | regulation of integrin activation (GO:0033623) | 3.09786550 |
| 87 | lymphocyte migration (GO:0072676) | 3.09009539 |
| 88 | positive regulation of T-helper cell differentiation (GO:0045624) | 3.07759168 |
| 89 | T cell migration (GO:0072678) | 3.07532101 |
| 90 | negative regulation of lipid storage (GO:0010888) | 3.07173246 |
| 91 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 3.06732068 |
| 92 | germinal center formation (GO:0002467) | 3.06246193 |
| 93 | regulation of NF-kappaB import into nucleus (GO:0042345) | 3.05335973 |
| 94 | regulation of interleukin-12 production (GO:0032655) | 3.05142131 |
| 95 | leukocyte mediated cytotoxicity (GO:0001909) | 3.05076695 |
| 96 | cytokine secretion (GO:0050663) | 3.04902485 |
| 97 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.03362787 |
| 98 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.03362787 |
| 99 | modulation by symbiont of host immune response (GO:0052553) | 3.03362787 |
| 100 | positive regulation by symbiont of host defense response (GO:0052509) | 3.03362787 |
| 101 | modulation by symbiont of host defense response (GO:0052031) | 3.03362787 |
| 102 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.03362787 |
| 103 | regulation of T-helper 2 cell differentiation (GO:0045628) | 3.02594105 |
| 104 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.00046265 |
| 105 | positive regulation of interferon-beta production (GO:0032728) | 2.98195766 |
| 106 | positive regulation of nitric oxide biosynthetic process (GO:0045429) | 2.96070173 |
| 107 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 2.95264972 |
| 108 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.94882741 |
| 109 | macrophage activation involved in immune response (GO:0002281) | 2.94295583 |
| 110 | detection of molecule of bacterial origin (GO:0032490) | 2.92674539 |
| 111 | lymphocyte mediated immunity (GO:0002449) | 2.92146322 |
| 112 | cellular response to lipopolysaccharide (GO:0071222) | 2.92050240 |
| 113 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 2.91952078 |
| 114 | regulation of type 2 immune response (GO:0002828) | 2.91753242 |
| 115 | cellular response to molecule of bacterial origin (GO:0071219) | 2.91091472 |
| 116 | positive regulation of protein oligomerization (GO:0032461) | 2.90126731 |
| 117 | T-helper 1 type immune response (GO:0042088) | 2.89670130 |
| 118 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 2.86672978 |
| 119 | positive regulation of interleukin-6 production (GO:0032755) | 2.85908868 |
| 120 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.85570128 |
| 121 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 2.81339059 |
| 122 | thymic T cell selection (GO:0045061) | 2.80869748 |
| 123 | detection of other organism (GO:0098543) | 2.80084311 |
| 124 | regulation of B cell differentiation (GO:0045577) | 2.79894313 |
| 125 | regulation of mononuclear cell migration (GO:0071675) | 2.79864883 |
| 126 | positive regulation of interleukin-1 beta secretion (GO:0050718) | 2.75744854 |
| 127 | natural killer cell differentiation (GO:0001779) | 2.74386085 |
| 128 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.73160455 |
| 129 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.72746824 |
| 130 | T cell selection (GO:0045058) | 2.72217282 |
| 131 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.71863489 |
| 132 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 2.71574618 |
| 133 | regulation of nitric oxide biosynthetic process (GO:0045428) | 2.71305421 |
| 134 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.70233640 |
| 135 | natural killer cell activation (GO:0030101) | 2.69256572 |
| 136 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 2.68839971 |
| 137 | positive regulation of acute inflammatory response (GO:0002675) | 2.67781832 |
| 138 | negative regulation of necrotic cell death (GO:0060547) | 2.67383516 |
| 139 | regulation of interleukin-1 beta secretion (GO:0050706) | 2.67376117 |
| 140 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli | 2.66349675 |
| 141 | positive regulation of type 2 immune response (GO:0002830) | 2.65233600 |
| 142 | regulation of cellular extravasation (GO:0002691) | 2.65223267 |
| 143 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 2.64370605 |
| 144 | positive regulation of macrophage cytokine production (GO:0060907) | 2.64285395 |
| 145 | regulation of tolerance induction (GO:0002643) | 2.64137998 |
| 146 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 2.64134991 |
| 147 | positive regulation of natural killer cell activation (GO:0032816) | 2.63875297 |
| 148 | regulation of heterotypic cell-cell adhesion (GO:0034114) | 2.62823123 |
| 149 | cellular response to biotic stimulus (GO:0071216) | 2.62729958 |
| 150 | positive regulation of cytokine biosynthetic process (GO:0042108) | 2.62285288 |
| 151 | modulation of growth of symbiont involved in interaction with host (GO:0044144) | 2.61942210 |
| 152 | regulation of growth of symbiont in host (GO:0044126) | 2.61942210 |
| 153 | negative regulation of growth of symbiont in host (GO:0044130) | 2.61942210 |
| 154 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 2.61942210 |
| 155 | positive regulation of interleukin-10 production (GO:0032733) | 2.61865281 |
| 156 | regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 2.61542879 |
| 157 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 2.59752331 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 6.04424860 |
| 2 | * IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.45961519 |
| 3 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.23724786 |
| 4 | * FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.07761848 |
| 5 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.86612390 |
| 6 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.80436770 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.70982772 |
| 8 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.48236980 |
| 9 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.35015533 |
| 10 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.34151364 |
| 11 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 3.25503109 |
| 12 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 3.20698296 |
| 13 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.20290106 |
| 14 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 3.10374585 |
| 15 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.86233202 |
| 16 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.79126776 |
| 17 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.78279183 |
| 18 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.71954143 |
| 19 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.50199182 |
| 20 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.41932114 |
| 21 | GATA1_22025678_ChIP-Seq_K562_Human | 2.32150309 |
| 22 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.30894764 |
| 23 | * STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.17671495 |
| 24 | * RUNX_20019798_ChIP-Seq_JUKART_Human | 2.09819510 |
| 25 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.06054469 |
| 26 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.05748242 |
| 27 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.04861021 |
| 28 | MAF_26560356_Chip-Seq_TH1_Human | 1.96339767 |
| 29 | MYB_26560356_Chip-Seq_TH2_Human | 1.92245900 |
| 30 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 1.88541436 |
| 31 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.82386684 |
| 32 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.81906732 |
| 33 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.75886688 |
| 34 | MYB_26560356_Chip-Seq_TH1_Human | 1.74730847 |
| 35 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.74551392 |
| 36 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.71865904 |
| 37 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.69927594 |
| 38 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.63683936 |
| 39 | SPI1_23127762_ChIP-Seq_K562_Human | 1.63244000 |
| 40 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.54881655 |
| 41 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.54563898 |
| 42 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.53936976 |
| 43 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.46641061 |
| 44 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.45998107 |
| 45 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.44631909 |
| 46 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.39214558 |
| 47 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.39045500 |
| 48 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.38946933 |
| 49 | MYC_22102868_ChIP-Seq_BL_Human | 1.37321744 |
| 50 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.37313200 |
| 51 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.36693957 |
| 52 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.36020819 |
| 53 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.33507099 |
| 54 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.33084400 |
| 55 | * GATA3_27048872_Chip-Seq_THYMUS_Human | 1.32446022 |
| 56 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.30889400 |
| 57 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.29458962 |
| 58 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.22865747 |
| 59 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.19630867 |
| 60 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.19630867 |
| 61 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.19630867 |
| 62 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.15492026 |
| 63 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.14841566 |
| 64 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.13631233 |
| 65 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.12002513 |
| 66 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.11785224 |
| 67 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.10888145 |
| 68 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.09918021 |
| 69 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.09658224 |
| 70 | * UTX_26944678_Chip-Seq_JUKART_Human | 1.09388990 |
| 71 | * MAF_26560356_Chip-Seq_TH2_Human | 1.01354522 |
| 72 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.01231571 |
| 73 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.00849210 |
| 74 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.99739674 |
| 75 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.99071668 |
| 76 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.99071668 |
| 77 | * GATA3_26560356_Chip-Seq_TH2_Human | 0.98802948 |
| 78 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.97140301 |
| 79 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.96679515 |
| 80 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.96249741 |
| 81 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 0.95791605 |
| 82 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.91689502 |
| 83 | * GATA1_19941826_ChIP-Seq_K562_Human | 0.89194835 |
| 84 | * KDM2B_26808549_Chip-Seq_K562_Human | 0.86253560 |
| 85 | * KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.85293138 |
| 86 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.84615286 |
| 87 | * ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.84081182 |
| 88 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.83854849 |
| 89 | * RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.83785119 |
| 90 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.83357284 |
| 91 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82514467 |
| 92 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.81138550 |
| 93 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.80670741 |
| 94 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.80568460 |
| 95 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.80274212 |
| 96 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.79680581 |
| 97 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.79667527 |
| 98 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.79112210 |
| 99 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.78679195 |
| 100 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.78572503 |
| 101 | * GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.78445376 |
| 102 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.76850739 |
| 103 | TP53_16413492_ChIP-PET_HCT116_Human | 0.76667014 |
| 104 | * LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.76642076 |
| 105 | TP63_23658742_ChIP-Seq_EP156T_Human | 0.76309326 |
| 106 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.76267005 |
| 107 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.74987983 |
| 108 | * KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.74694737 |
| 109 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.73101935 |
| 110 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.72916351 |
| 111 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.72874881 |
| 112 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.72386757 |
| 113 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.71107802 |
| 114 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.69824724 |
| 115 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.69521309 |
| 116 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.69463943 |
| 117 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.68727952 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002254_reproductive_system_inflammat | 5.55441467 |
| 2 | MP0002138_abnormal_hepatobiliary_system | 4.48097991 |
| 3 | MP0001835_abnormal_antigen_presentation | 4.33594529 |
| 4 | MP0004510_myositis | 3.99832086 |
| 5 | MP0000685_abnormal_immune_system | 3.49612504 |
| 6 | MP0000569_abnormal_digit_pigmentation | 3.31087979 |
| 7 | MP0005387_immune_system_phenotype | 3.07244316 |
| 8 | MP0001790_abnormal_immune_system | 3.07244316 |
| 9 | MP0003436_decreased_susceptibility_to | 2.98321964 |
| 10 | MP0002166_altered_tumor_susceptibility | 2.92272581 |
| 11 | MP0002148_abnormal_hypersensitivity_rea | 2.73299328 |
| 12 | MP0001348_abnormal_lacrimal_gland | 2.71009770 |
| 13 | MP0001800_abnormal_humoral_immune | 2.64951354 |
| 14 | MP0005000_abnormal_immune_tolerance | 2.57978832 |
| 15 | MP0002009_preneoplasia | 2.48522155 |
| 16 | MP0005671_abnormal_response_to | 2.47183878 |
| 17 | MP0002452_abnormal_antigen_presenting | 2.46542898 |
| 18 | MP0009785_altered_susceptibility_to | 2.40583546 |
| 19 | MP0002006_tumorigenesis | 2.38126075 |
| 20 | MP0005310_abnormal_salivary_gland | 2.35533319 |
| 21 | MP0002723_abnormal_immune_serum | 2.29929718 |
| 22 | MP0002419_abnormal_innate_immunity | 2.23023188 |
| 23 | MP0005025_abnormal_response_to | 2.15512616 |
| 24 | MP0001819_abnormal_immune_cell | 2.15153793 |
| 25 | MP0002420_abnormal_adaptive_immunity | 2.11931998 |
| 26 | MP0008004_abnormal_stomach_pH | 2.04535475 |
| 27 | MP0004947_skin_inflammation | 2.02990215 |
| 28 | MP0003303_peritoneal_inflammation | 2.02835980 |
| 29 | MP0002277_abnormal_respiratory_mucosa | 1.99318732 |
| 30 | MP0010234_abnormal_vibrissa_follicle | 1.97515721 |
| 31 | MP0002877_abnormal_melanocyte_morpholog | 1.87638849 |
| 32 | MP0006082_CNS_inflammation | 1.81965794 |
| 33 | MP0001873_stomach_inflammation | 1.81776312 |
| 34 | MP0001853_heart_inflammation | 1.73755288 |
| 35 | MP0000716_abnormal_immune_system | 1.68737749 |
| 36 | MP0002398_abnormal_bone_marrow | 1.65180435 |
| 37 | MP0002405_respiratory_system_inflammati | 1.63759009 |
| 38 | MP0010352_gastrointestinal_tract_polyps | 1.54148895 |
| 39 | MP0002163_abnormal_gland_morphology | 1.53276982 |
| 40 | MP0003448_altered_tumor_morphology | 1.48181337 |
| 41 | MP0010155_abnormal_intestine_physiology | 1.48003968 |
| 42 | MP0005451_abnormal_body_composition | 1.46984287 |
| 43 | MP0003300_gastrointestinal_ulcer | 1.36043358 |
| 44 | MP0003453_abnormal_keratinocyte_physiol | 1.35069106 |
| 45 | MP0003091_abnormal_cell_migration | 1.34980288 |
| 46 | MP0005166_decreased_susceptibility_to | 1.34590155 |
| 47 | MP0003763_abnormal_thymus_physiology | 1.33847942 |
| 48 | MP0002429_abnormal_blood_cell | 1.33278989 |
| 49 | MP0001845_abnormal_inflammatory_respons | 1.31774892 |
| 50 | MP0002796_impaired_skin_barrier | 1.31209343 |
| 51 | MP0003656_abnormal_erythrocyte_physiolo | 1.29295010 |
| 52 | MP0000343_altered_response_to | 1.28641537 |
| 53 | MP0000689_abnormal_spleen_morphology | 1.28353257 |
| 54 | MP0005058_abnormal_lysosome_morphology | 1.28137111 |
| 55 | MP0002396_abnormal_hematopoietic_system | 1.25533695 |
| 56 | MP0005174_abnormal_tail_pigmentation | 1.24822577 |
| 57 | MP0002722_abnormal_immune_system | 1.24775970 |
| 58 | MP0005464_abnormal_platelet_physiology | 1.23030660 |
| 59 | MP0003172_abnormal_lysosome_physiology | 1.22852755 |
| 60 | MP0010678_abnormal_skin_adnexa | 1.22676768 |
| 61 | MP0003705_abnormal_hypodermis_morpholog | 1.18429833 |
| 62 | MP0005076_abnormal_cell_differentiation | 1.18261155 |
| 63 | MP0003183_abnormal_peptide_metabolism | 1.18127653 |
| 64 | MP0001533_abnormal_skeleton_physiology | 1.13953766 |
| 65 | MP0005164_abnormal_response_to | 1.13287466 |
| 66 | MP0001346_abnormal_lacrimal_gland | 1.12825900 |
| 67 | MP0001545_abnormal_hematopoietic_system | 1.12179774 |
| 68 | MP0005397_hematopoietic_system_phenotyp | 1.12179774 |
| 69 | MP0005167_abnormal_blood-brain_barrier | 1.11721586 |
| 70 | MP0003566_abnormal_cell_adhesion | 1.09517764 |
| 71 | MP0008469_abnormal_protein_level | 1.07719139 |
| 72 | MP0002998_abnormal_bone_remodeling | 1.04932061 |
| 73 | MP0009764_decreased_sensitivity_to | 1.04473831 |
| 74 | MP0008057_abnormal_DNA_replication | 1.01889706 |
| 75 | MP0000604_amyloidosis | 1.01341690 |
| 76 | MP0009278_abnormal_bone_marrow | 1.00366714 |
| 77 | MP0009765_abnormal_xenobiotic_induced | 0.98726383 |
| 78 | MP0000703_abnormal_thymus_morphology | 0.96421611 |
| 79 | MP0002139_abnormal_hepatobiliary_system | 0.95202793 |
| 80 | MP0003724_increased_susceptibility_to | 0.94627458 |
| 81 | MP0000383_abnormal_hair_follicle | 0.93601028 |
| 82 | MP0000371_diluted_coat_color | 0.92282180 |
| 83 | MP0009840_abnormal_foam_cell | 0.91973671 |
| 84 | MP0005666_abnormal_adipose_tissue | 0.88775827 |
| 85 | MP0004381_abnormal_hair_follicle | 0.87447893 |
| 86 | MP0001542_abnormal_bone_strength | 0.86606661 |
| 87 | MP0003828_pulmonary_edema | 0.85449604 |
| 88 | MP0000858_altered_metastatic_potential | 0.84921719 |
| 89 | MP0004808_abnormal_hematopoietic_stem | 0.84731098 |
| 90 | MP0005023_abnormal_wound_healing | 0.84371256 |
| 91 | MP0005075_abnormal_melanosome_morpholog | 0.82593465 |
| 92 | MP0002060_abnormal_skin_morphology | 0.81494497 |
| 93 | MP0009333_abnormal_splenocyte_physiolog | 0.80366224 |
| 94 | MP0002332_abnormal_exercise_endurance | 0.79473171 |
| 95 | MP0002933_joint_inflammation | 0.78939347 |
| 96 | MP0001243_abnormal_dermal_layer | 0.78133711 |
| 97 | MP0004858_abnormal_nervous_system | 0.78051161 |
| 98 | MP0003221_abnormal_cardiomyocyte_apopto | 0.77719367 |
| 99 | MP0005647_abnormal_sex_gland | 0.75995078 |
| 100 | MP0003191_abnormal_cellular_cholesterol | 0.75556460 |
| 101 | MP0001851_eye_inflammation | 0.74203663 |
| 102 | MP0009115_abnormal_fat_cell | 0.74013268 |
| 103 | MP0010307_abnormal_tumor_latency | 0.72584943 |
| 104 | MP0001881_abnormal_mammary_gland | 0.72167981 |
| 105 | MP0000627_abnormal_mammary_gland | 0.69333102 |
| 106 | MP0000767_abnormal_smooth_muscle | 0.67979492 |
| 107 | MP0005275_abnormal_skin_tensile | 0.67739480 |
| 108 | MP0003195_calcinosis | 0.67657222 |
| 109 | MP0003690_abnormal_glial_cell | 0.67557419 |
| 110 | MP0000249_abnormal_blood_vessel | 0.67071698 |
| 111 | MP0003045_fibrosis | 0.66799902 |
| 112 | MP0000015_abnormal_ear_pigmentation | 0.64675028 |
| 113 | MP0005257_abnormal_intraocular_pressure | 0.62514643 |
| 114 | MP0008961_abnormal_basal_metabolism | 0.62258872 |
| 115 | MP0001216_abnormal_epidermal_layer | 0.60772706 |
| 116 | MP0002136_abnormal_kidney_physiology | 0.59191804 |
| 117 | MP0003075_altered_response_to | 0.58974424 |
| 118 | MP0005379_endocrine/exocrine_gland_phen | 0.56982654 |
| 119 | MP0000490_abnormal_crypts_of | 0.54297753 |
| 120 | MP0009763_increased_sensitivity_to | 0.53199229 |
| 121 | MP0004264_abnormal_extraembryonic_tissu | 0.53008205 |
| 122 | MP0003866_abnormal_defecation | 0.52508804 |
| 123 | MP0005390_skeleton_phenotype | 0.52107321 |
| 124 | MP0004185_abnormal_adipocyte_glucose | 0.52101112 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Eczematoid dermatitis (HP:0000976) | 5.06627577 |
| 2 | Recurrent bacterial skin infections (HP:0005406) | 4.97647098 |
| 3 | Recurrent abscess formation (HP:0002722) | 4.89803058 |
| 4 | Recurrent fungal infections (HP:0002841) | 4.84386496 |
| 5 | Recurrent viral infections (HP:0004429) | 4.59158823 |
| 6 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.50527133 |
| 7 | Orchitis (HP:0100796) | 4.07355440 |
| 8 | Mediastinal lymphadenopathy (HP:0100721) | 4.02496113 |
| 9 | Myositis (HP:0100614) | 3.97119988 |
| 10 | Retrobulbar optic neuritis (HP:0100654) | 3.75756755 |
| 11 | Optic neuritis (HP:0100653) | 3.75756755 |
| 12 | Myocardial infarction (HP:0001658) | 3.73107396 |
| 13 | Vacuolated lymphocytes (HP:0001922) | 3.56086594 |
| 14 | Abnormality of macrophages (HP:0004311) | 3.54535943 |
| 15 | Recurrent skin infections (HP:0001581) | 3.52676154 |
| 16 | Pulmonary infiltrates (HP:0002113) | 3.51339780 |
| 17 | Recurrent cutaneous fungal infections (HP:0011370) | 3.50699330 |
| 18 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.50699330 |
| 19 | Increased IgE level (HP:0003212) | 3.50627894 |
| 20 | Vasculitis (HP:0002633) | 3.49496152 |
| 21 | Periodontitis (HP:0000704) | 3.45320856 |
| 22 | Increased IgM level (HP:0003496) | 3.43581226 |
| 23 | Nasal polyposis (HP:0100582) | 3.41387020 |
| 24 | Chronic otitis media (HP:0000389) | 3.38266010 |
| 25 | Fatigue (HP:0012378) | 3.38198490 |
| 26 | Gingivitis (HP:0000230) | 3.37828114 |
| 27 | Hematochezia (HP:0002573) | 3.35683949 |
| 28 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.35211226 |
| 29 | Autoimmune thrombocytopenia (HP:0001973) | 3.33905066 |
| 30 | Gangrene (HP:0100758) | 3.24674756 |
| 31 | Colitis (HP:0002583) | 3.21137065 |
| 32 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.20656065 |
| 33 | Gastrointestinal infarctions (HP:0005244) | 3.19608941 |
| 34 | Leukocytosis (HP:0001974) | 3.18215789 |
| 35 | Arterial thrombosis (HP:0004420) | 3.13540994 |
| 36 | Eosinophilia (HP:0001880) | 3.12988600 |
| 37 | Dysostosis multiplex (HP:0000943) | 3.10515190 |
| 38 | Peritonitis (HP:0002586) | 3.07093706 |
| 39 | Abnormality of the nasal mucosa (HP:0000433) | 2.99061130 |
| 40 | Loss of speech (HP:0002371) | 2.98727564 |
| 41 | Disinhibition (HP:0000734) | 2.96733321 |
| 42 | Gingival bleeding (HP:0000225) | 2.93063158 |
| 43 | Abnormality of the fingertips (HP:0001211) | 2.81244283 |
| 44 | Prostate neoplasm (HP:0100787) | 2.79140393 |
| 45 | Agammaglobulinemia (HP:0004432) | 2.76627148 |
| 46 | Hypergammaglobulinemia (HP:0010702) | 2.70258990 |
| 47 | Inflammation of the large intestine (HP:0002037) | 2.68266975 |
| 48 | Granulocytopenia (HP:0001913) | 2.63805898 |
| 49 | Chest pain (HP:0100749) | 2.63017034 |
| 50 | Esophageal varix (HP:0002040) | 2.62801954 |
| 51 | Cellulitis (HP:0100658) | 2.62105468 |
| 52 | Thrombocytosis (HP:0001894) | 2.61720629 |
| 53 | Panhypogammaglobulinemia (HP:0003139) | 2.60189096 |
| 54 | Keratoconjunctivitis sicca (HP:0001097) | 2.54422971 |
| 55 | Keratoconjunctivitis (HP:0001096) | 2.53626136 |
| 56 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.52183689 |
| 57 | Polycythemia (HP:0001901) | 2.51344596 |
| 58 | Osteolytic defects of the hand bones (HP:0009699) | 2.49470719 |
| 59 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.49470719 |
| 60 | Stomatitis (HP:0010280) | 2.48788486 |
| 61 | Thick nail (HP:0001805) | 2.46498568 |
| 62 | Gastrointestinal inflammation (HP:0004386) | 2.45844776 |
| 63 | Premature loss of primary teeth (HP:0006323) | 2.44897418 |
| 64 | Anhidrosis (HP:0000970) | 2.39901661 |
| 65 | Abnormality of T cell number (HP:0011839) | 2.35906087 |
| 66 | Curly hair (HP:0002212) | 2.34897907 |
| 67 | Hemoptysis (HP:0002105) | 2.34772795 |
| 68 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.32903409 |
| 69 | Abnormality of eosinophils (HP:0001879) | 2.31516732 |
| 70 | Meningitis (HP:0001287) | 2.29610570 |
| 71 | Parakeratosis (HP:0001036) | 2.29578739 |
| 72 | Cortical dysplasia (HP:0002539) | 2.28647922 |
| 73 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.28185811 |
| 74 | Mucopolysacchariduria (HP:0008155) | 2.28185811 |
| 75 | Abnormality of the pleura (HP:0002103) | 2.26933425 |
| 76 | Porencephaly (HP:0002132) | 2.26878422 |
| 77 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.26341055 |
| 78 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.26341055 |
| 79 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.26341055 |
| 80 | Tetraparesis (HP:0002273) | 2.26161497 |
| 81 | Absent frontal sinuses (HP:0002688) | 2.24322407 |
| 82 | Recurrent bronchitis (HP:0002837) | 2.21649237 |
| 83 | Alveolar cell carcinoma (HP:0006519) | 2.21598065 |
| 84 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.18895651 |
| 85 | Fused cervical vertebrae (HP:0002949) | 2.18450325 |
| 86 | Pustule (HP:0200039) | 2.18368701 |
| 87 | Amyloidosis (HP:0011034) | 2.18148768 |
| 88 | Emphysema (HP:0002097) | 2.17826540 |
| 89 | Erythroderma (HP:0001019) | 2.16806245 |
| 90 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.15356103 |
| 91 | Polyneuropathy (HP:0001271) | 2.12152935 |
| 92 | Interstitial pulmonary disease (HP:0006530) | 2.11958836 |
| 93 | Basal ganglia calcification (HP:0002135) | 2.11284133 |
| 94 | Autoimmune hemolytic anemia (HP:0001890) | 2.10412516 |
| 95 | Spontaneous hematomas (HP:0007420) | 2.09768419 |
| 96 | Spondylolisthesis (HP:0003302) | 2.09722096 |
| 97 | Cheilitis (HP:0100825) | 2.08193069 |
| 98 | Abnormality of the pericardium (HP:0001697) | 2.06139644 |
| 99 | Lip pit (HP:0100267) | 2.05755611 |
| 100 | Abnormality of the periventricular white matter (HP:0002518) | 2.05629290 |
| 101 | Stomach cancer (HP:0012126) | 2.04910263 |
| 102 | Chronic diarrhea (HP:0002028) | 2.04547485 |
| 103 | Portal hypertension (HP:0001409) | 2.01874130 |
| 104 | Osteomyelitis (HP:0002754) | 2.01703159 |
| 105 | Obstructive lung disease (HP:0006536) | 2.00823603 |
| 106 | Chronic obstructive pulmonary disease (HP:0006510) | 2.00823603 |
| 107 | T lymphocytopenia (HP:0005403) | 1.98357433 |
| 108 | Axonal loss (HP:0003447) | 1.97141126 |
| 109 | Encephalitis (HP:0002383) | 1.96766214 |
| 110 | Amaurosis fugax (HP:0100576) | 1.96519852 |
| 111 | Vertigo (HP:0002321) | 1.96074097 |
| 112 | Frequent falls (HP:0002359) | 1.92130648 |
| 113 | Pulmonary artery stenosis (HP:0004415) | 1.91377511 |
| 114 | Hydroxyprolinuria (HP:0003080) | 1.90857795 |
| 115 | Abnormality of proline metabolism (HP:0010907) | 1.90857795 |
| 116 | Restrictive lung disease (HP:0002091) | 1.90600709 |
| 117 | Increased cerebral lipofuscin (HP:0011813) | 1.89628265 |
| 118 | Anorexia (HP:0002039) | 1.89398813 |
| 119 | Xerostomia (HP:0000217) | 1.89390329 |
| 120 | Systemic lupus erythematosus (HP:0002725) | 1.88884990 |
| 121 | Persistence of primary teeth (HP:0006335) | 1.88495431 |
| 122 | Abnormality of glycolipid metabolism (HP:0010969) | 1.88405217 |
| 123 | Abnormality of liposaccharide metabolism (HP:0010968) | 1.88405217 |
| 124 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 1.88405217 |
| 125 | Abnormality of the hepatic vasculature (HP:0006707) | 1.87906576 |
| 126 | Ectropion (HP:0000656) | 1.87739446 |
| 127 | Aplasia cutis congenita (HP:0001057) | 1.87432969 |
| 128 | Combined immunodeficiency (HP:0005387) | 1.86584871 |
| 129 | Urticaria (HP:0001025) | 1.85940519 |
| 130 | Keratitis (HP:0000491) | 1.85379305 |
| 131 | Thyroiditis (HP:0100646) | 1.85232819 |
| 132 | Hypochromic anemia (HP:0001931) | 1.84183244 |
| 133 | Pulmonary embolism (HP:0002204) | 1.83973706 |
| 134 | Gastrointestinal stroma tumor (HP:0100723) | 1.82461088 |
| 135 | Albinism (HP:0001022) | 1.82390960 |
| 136 | Glomerulonephritis (HP:0000099) | 1.82021394 |
| 137 | Abnormality of the salivary glands (HP:0010286) | 1.80073381 |
| 138 | Aplasia/Hypoplasia involving the sinuses (HP:0009120) | 1.79280568 |
| 139 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.78516524 |
| 140 | IgA deficiency (HP:0002720) | 1.77537785 |
| 141 | Abnormality of the columella (HP:0009929) | 1.76299863 |
| 142 | Malnutrition (HP:0004395) | 1.75235101 |
| 143 | Abnormality of secondary sexual hair (HP:0009888) | 1.72275639 |
| 144 | Abnormality of the axillary hair (HP:0100134) | 1.72275639 |
| 145 | Joint swelling (HP:0001386) | 1.71170517 |
| 146 | Mutism (HP:0002300) | 1.70091470 |
| 147 | Bladder neoplasm (HP:0009725) | 1.68611040 |
| 148 | Bladder carcinoma (HP:0002862) | 1.68611040 |
| 149 | Increased serum ferritin (HP:0003281) | 1.68156528 |
| 150 | Abnormality of the costochondral junction (HP:0000919) | 1.67910194 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP3K14 | 5.57507905 |
| 2 | MAP3K13 | 3.69591720 |
| 3 | TYK2 | 3.67634322 |
| 4 | IKBKB | 3.58055585 |
| 5 | CDK12 | 3.56845987 |
| 6 | JAK3 | 3.17861935 |
| 7 | TBK1 | 2.91577926 |
| 8 | CHUK | 2.81022984 |
| 9 | RIPK4 | 2.66825173 |
| 10 | PRPF4B | 2.57788648 |
| 11 | JAK1 | 2.51360223 |
| 12 | IKBKE | 2.50495000 |
| 13 | CSF1R | 2.13028680 |
| 14 | IRAK4 | 2.06443397 |
| 15 | BRD4 | 1.97700354 |
| 16 | TAOK2 | 1.95749981 |
| 17 | KIT | 1.90683381 |
| 18 | DDR2 | 1.84810651 |
| 19 | FGFR3 | 1.84761980 |
| 20 | EPHB1 | 1.78072604 |
| 21 | MAP4K1 | 1.76558468 |
| 22 | GRK6 | 1.75085460 |
| 23 | PRKAA2 | 1.56249149 |
| 24 | FGFR4 | 1.53465183 |
| 25 | ERN1 | 1.50361568 |
| 26 | STK24 | 1.49745149 |
| 27 | BLK | 1.44330319 |
| 28 | EPHA3 | 1.43658149 |
| 29 | IRAK2 | 1.39213821 |
| 30 | MAP3K10 | 1.38618645 |
| 31 | FLT3 | 1.38458065 |
| 32 | LATS2 | 1.37460065 |
| 33 | TGFBR2 | 1.27305811 |
| 34 | SIK2 | 1.22242831 |
| 35 | JAK2 | 1.18614328 |
| 36 | TAOK1 | 1.16850161 |
| 37 | PKN1 | 1.16692007 |
| 38 | CDC42BPA | 1.16539528 |
| 39 | IRAK3 | 1.15847708 |
| 40 | STK10 | 1.15215667 |
| 41 | CSK | 1.14197924 |
| 42 | TAOK3 | 1.11827746 |
| 43 | MAP3K1 | 1.11233138 |
| 44 | SYK | 1.10250431 |
| 45 | LCK | 1.01274199 |
| 46 | PTK6 | 1.00626464 |
| 47 | HCK | 0.99513565 |
| 48 | ZAP70 | 0.96215750 |
| 49 | RIPK1 | 0.96205371 |
| 50 | PIM1 | 0.94762273 |
| 51 | NEK9 | 0.92949036 |
| 52 | TTN | 0.92888528 |
| 53 | ACVR1B | 0.92050682 |
| 54 | NME2 | 0.89450235 |
| 55 | BMX | 0.86954635 |
| 56 | BTK | 0.81840553 |
| 57 | TXK | 0.81530363 |
| 58 | GRK5 | 0.79830481 |
| 59 | RPS6KA4 | 0.78703718 |
| 60 | EIF2AK2 | 0.77417835 |
| 61 | ITK | 0.76076827 |
| 62 | MAP3K7 | 0.74664305 |
| 63 | MATK | 0.74637130 |
| 64 | MOS | 0.74319321 |
| 65 | MELK | 0.72206624 |
| 66 | DMPK | 0.71294339 |
| 67 | WNK1 | 0.69579196 |
| 68 | YES1 | 0.69289219 |
| 69 | NLK | 0.68355499 |
| 70 | STK4 | 0.67876159 |
| 71 | FGR | 0.67127383 |
| 72 | IRAK1 | 0.66819689 |
| 73 | MAPKAPK2 | 0.65960456 |
| 74 | BMPR2 | 0.65122624 |
| 75 | MAP3K5 | 0.64545889 |
| 76 | HIPK2 | 0.63478879 |
| 77 | PDGFRA | 0.63230268 |
| 78 | DYRK3 | 0.56180965 |
| 79 | PRKCQ | 0.55913669 |
| 80 | SIK3 | 0.55453349 |
| 81 | MAPK7 | 0.54505416 |
| 82 | MST4 | 0.53154412 |
| 83 | SGK1 | 0.52970407 |
| 84 | ABL1 | 0.52966399 |
| 85 | MARK3 | 0.52280151 |
| 86 | PIM2 | 0.51910648 |
| 87 | RET | 0.51805468 |
| 88 | CLK1 | 0.51510704 |
| 89 | EGFR | 0.50762011 |
| 90 | MAP2K3 | 0.50233946 |
| 91 | EIF2AK3 | 0.48198217 |
| 92 | TEC | 0.47954209 |
| 93 | GRK1 | 0.47020908 |
| 94 | PRKCD | 0.46807748 |
| 95 | GRK7 | 0.46608822 |
| 96 | PDK2 | 0.46203273 |
| 97 | CAMK1D | 0.45640162 |
| 98 | CDK9 | 0.45180573 |
| 99 | MAP3K3 | 0.45170471 |
| 100 | LYN | 0.44449564 |
| 101 | SIK1 | 0.44360000 |
| 102 | RPS6KC1 | 0.43555940 |
| 103 | RPS6KL1 | 0.43555940 |
| 104 | PDGFRB | 0.43211187 |
| 105 | MARK2 | 0.42876466 |
| 106 | CDK4 | 0.42515259 |
| 107 | CDK6 | 0.42208114 |
| 108 | FER | 0.42147417 |
| 109 | MAP3K9 | 0.41798298 |
| 110 | MAP3K2 | 0.41089982 |
| 111 | MAP3K11 | 0.40506782 |
| 112 | RPS6KA1 | 0.40447991 |
| 113 | TRPM7 | 0.40355917 |
| 114 | GSK3A | 0.40280169 |
| 115 | AKT3 | 0.39710104 |
| 116 | STK3 | 0.39608248 |
| 117 | BRSK2 | 0.39417251 |
| 118 | AKT1 | 0.39023372 |
| 119 | PAK4 | 0.38631216 |
| 120 | CAMK4 | 0.38593263 |
| 121 | MTOR | 0.37077796 |
| 122 | SGK3 | 0.36619072 |
| 123 | INSR | 0.36395882 |
| 124 | IGF1R | 0.35458309 |
| 125 | ADRBK2 | 0.34782949 |
| 126 | RPS6KA6 | 0.33742659 |
| 127 | PTK2 | 0.31003121 |
| 128 | FES | 0.30171278 |
| 129 | LRRK2 | 0.27957772 |
| 130 | ALK | 0.26650309 |
| 131 | DYRK1B | 0.24743243 |
| 132 | RPS6KA5 | 0.24743217 |
| 133 | TYRO3 | 0.24251194 |
| 134 | MAPK12 | 0.22274419 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 3.53973208 |
| 2 | Leishmaniasis_Homo sapiens_hsa05140 | 2.77536586 |
| 3 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.58704695 |
| 4 | Allograft rejection_Homo sapiens_hsa05330 | 2.48872322 |
| 5 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.47590072 |
| 6 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.45914426 |
| 7 | TNF signaling pathway_Homo sapiens_hsa04668 | 2.29965172 |
| 8 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.25860077 |
| 9 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.25383600 |
| 10 | Measles_Homo sapiens_hsa05162 | 2.20927481 |
| 11 | Toxoplasmosis_Homo sapiens_hsa05145 | 2.13707574 |
| 12 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.11166469 |
| 13 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.02305523 |
| 14 | Apoptosis_Homo sapiens_hsa04210 | 1.96468803 |
| 15 | Influenza A_Homo sapiens_hsa05164 | 1.73505310 |
| 16 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.73135550 |
| 17 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.72015244 |
| 18 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.68832863 |
| 19 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.64518446 |
| 20 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.63302339 |
| 21 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.62886275 |
| 22 | Tuberculosis_Homo sapiens_hsa05152 | 1.59349435 |
| 23 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.54163349 |
| 24 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.51821055 |
| 25 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.49422411 |
| 26 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.49080439 |
| 27 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.46483389 |
| 28 | Legionellosis_Homo sapiens_hsa05134 | 1.45782594 |
| 29 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.42521525 |
| 30 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.39928632 |
| 31 | Pertussis_Homo sapiens_hsa05133 | 1.39685892 |
| 32 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.29058401 |
| 33 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.28240165 |
| 34 | Shigellosis_Homo sapiens_hsa05131 | 1.27583386 |
| 35 | Malaria_Homo sapiens_hsa05144 | 1.19737924 |
| 36 | Viral myocarditis_Homo sapiens_hsa05416 | 1.19003058 |
| 37 | Hepatitis C_Homo sapiens_hsa05160 | 1.16935085 |
| 38 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.15280959 |
| 39 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.14889358 |
| 40 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.14432812 |
| 41 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.11987132 |
| 42 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.11837584 |
| 43 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.11438435 |
| 44 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.10177566 |
| 45 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.09162048 |
| 46 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.08471859 |
| 47 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.07744325 |
| 48 | Hepatitis B_Homo sapiens_hsa05161 | 1.06991364 |
| 49 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.03461428 |
| 50 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.02988454 |
| 51 | Bladder cancer_Homo sapiens_hsa05219 | 0.98993840 |
| 52 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.95528117 |
| 53 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.93397843 |
| 54 | Salmonella infection_Homo sapiens_hsa05132 | 0.89831306 |
| 55 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.87231269 |
| 56 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.85539710 |
| 57 | Asthma_Homo sapiens_hsa05310 | 0.85210359 |
| 58 | Insulin resistance_Homo sapiens_hsa04931 | 0.83964840 |
| 59 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.83748853 |
| 60 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.81953933 |
| 61 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.80135358 |
| 62 | Prion diseases_Homo sapiens_hsa05020 | 0.79426214 |
| 63 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.76767335 |
| 64 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.76547405 |
| 65 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.73602757 |
| 66 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.73357270 |
| 67 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.72422070 |
| 68 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.70165885 |
| 69 | HTLV-I infection_Homo sapiens_hsa05166 | 0.69736484 |
| 70 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.65677075 |
| 71 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.65388969 |
| 72 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.64545624 |
| 73 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.62934149 |
| 74 | Platelet activation_Homo sapiens_hsa04611 | 0.61476011 |
| 75 | Lysosome_Homo sapiens_hsa04142 | 0.61009720 |
| 76 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.59811363 |
| 77 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.59100033 |
| 78 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.58946259 |
| 79 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.56183542 |
| 80 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.55068274 |
| 81 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.53760816 |
| 82 | Amoebiasis_Homo sapiens_hsa05146 | 0.53709726 |
| 83 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.53576480 |
| 84 | Thyroid cancer_Homo sapiens_hsa05216 | 0.51548512 |
| 85 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.50826385 |
| 86 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.50485690 |
| 87 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.49489190 |
| 88 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.48020201 |
| 89 | Pathways in cancer_Homo sapiens_hsa05200 | 0.47700064 |
| 90 | Other glycan degradation_Homo sapiens_hsa00511 | 0.44792480 |
| 91 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.44330774 |
| 92 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.44265034 |
| 93 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.44021336 |
| 94 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.43816568 |
| 95 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.43468515 |
| 96 | Phagosome_Homo sapiens_hsa04145 | 0.42912087 |
| 97 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.42403737 |
| 98 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.41945858 |
| 99 | Adherens junction_Homo sapiens_hsa04520 | 0.41842767 |
| 100 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.37829394 |
| 101 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.36931144 |
| 102 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.36330029 |
| 103 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.34444653 |
| 104 | Circadian rhythm_Homo sapiens_hsa04710 | 0.34190249 |
| 105 | Endocytosis_Homo sapiens_hsa04144 | 0.33712496 |
| 106 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.33682974 |
| 107 | Prostate cancer_Homo sapiens_hsa05215 | 0.33301492 |
| 108 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.32040842 |
| 109 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.31701535 |
| 110 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.29098355 |
| 111 | Endometrial cancer_Homo sapiens_hsa05213 | 0.28826788 |
| 112 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.24075644 |
| 113 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.23959085 |

